Publications by authors named "Andreas Kulozik"

100Publications

Gene Therapy of the Hemoglobinopathies.

Hemasphere 2020 Oct 11;4(5):e479. Epub 2020 Sep 11.

Department of Pediatric Oncology, Hematology and Immunology, University of Heidelberg, Hopp - Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.

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http://dx.doi.org/10.1097/HS9.0000000000000479DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7489710PMC
October 2020

Plasticity of nuclear and cytoplasmic stress responses of RNA-binding proteins.

Nucleic Acids Res 2020 05;48(9):4725-4740

Molecular Medicine Partnership Unit (MMPU), Heidelberg University, Im Neuenheimer Feld 350, 69120 Heidelberg, Germany & European Molecular Biology Laboratory (EMBL), Meyerhofstrasse 1, 69117 Heidelberg, Germany.

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http://dx.doi.org/10.1093/nar/gkaa256DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7229827PMC
May 2020

Prexasertib (LY2606368) reduces clonogenic survival by inducing apoptosis in primary patient-derived osteosarcoma cells and synergizes with cisplatin and talazoparib.

Int J Cancer 2020 Aug 19;147(4):1059-1070. Epub 2019 Dec 19.

Department of Pediatric Oncology, Hematology and Immunology, Hopp Children's Cancer Research Center Heidelberg (KiTZ), Molecular Medicine Partnership Unit (MMPU) European Molecular Biology Laboratory (EMBL) and University of Heidelberg, Heidelberg, Germany.

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http://dx.doi.org/10.1002/ijc.32814DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7384073PMC
August 2020

The German National Registry of Primary Immunodeficiencies (2012-2017).

Authors:
Sabine M El-Helou Anika-Kerstin Biegner Sebastian Bode Stephan R Ehl Maximilian Heeg Maria E Maccari Henrike Ritterbusch Carsten Speckmann Stephan Rusch Raphael Scheible Klaus Warnatz Faranaz Atschekzei Renata Beider Diana Ernst Stev Gerschmann Alexandra Jablonka Gudrun Mielke Reinhold E Schmidt Gesine Schürmann Georgios Sogkas Ulrich H Baumann Christian Klemann Dorothee Viemann Horst von Bernuth Renate Krüger Leif G Hanitsch Carmen M Scheibenbogen Kirsten Wittke Michael H Albert Anna Eichinger Fabian Hauck Christoph Klein Anita Rack-Hoch Franz M Sollinger Anne Avila Michael Borte Stephan Borte Maria Fasshauer Anja Hauenherm Nils Kellner Anna H Müller Anett Ülzen Peter Bader Shahrzad Bakhtiar Jae-Yun Lee Ursula Heß Ralf Schubert Sandra Wölke Stefan Zielen Sujal Ghosh Hans-Juergen Laws Jennifer Neubert Prasad T Oommen Manfred Hönig Ansgar Schulz Sandra Steinmann Klaus Schwarz Gregor Dückers Beate Lamers Vanessa Langemeyer Tim Niehues Sonu Shai Dagmar Graf Carmen Müglich Marc T Schmalzing Eva C Schwaneck Hans-Peter Tony Johannes Dirks Gabriele Haase Johannes G Liese Henner Morbach Dirk Foell Antje Hellige Helmut Wittkowski Katja Masjosthusmann Michael Mohr Linda Geberzahn Christian M Hedrich Christiane Müller Angela Rösen-Wolff Joachim Roesler Antje Zimmermann Uta Behrends Nikolaus Rieber Uwe Schauer Rupert Handgretinger Ursula Holzer Jörg Henes Lothar Kanz Christoph Boesecke Jürgen K Rockstroh Carolynne Schwarze-Zander Jan-Christian Wasmuth Dagmar Dilloo Brigitte Hülsmann Stefan Schönberger Stefan Schreiber Rainald Zeuner Tobias Ankermann Philipp von Bismarck Hans-Iko Huppertz Petra Kaiser-Labusch Johann Greil Donate Jakoby Andreas E Kulozik Markus Metzler Nora Naumann-Bartsch Bettina Sobik Norbert Graf Sabine Heine Robin Kobbe Kai Lehmberg Ingo Müller Friedrich Herrmann Gerd Horneff Ariane Klein Joachim Peitz Nadine Schmidt Stefan Bielack Ute Groß-Wieltsch Carl F Classen Jessica Klasen Peter Deutz Dirk Kamitz Lisa Lassay Klaus Tenbrock Norbert Wagner Benedikt Bernbeck Bastian Brummel Eusebia Lara-Villacanas Esther Münstermann Dominik T Schneider Nadine Tietsch Marco Westkemper Michael Weiß Christof Kramm Ingrid Kühnle Silke Kullmann Hermann Girschick Christof Specker Elisabeth Vinnemeier-Laubenthal Henriette Haenicke Claudia Schulz Lothar Schweigerer Thomas G Müller Martina Stiefel Bernd H Belohradsky Veronika Soetedjo Gerhard Kindle Bodo Grimbacher

Front Immunol 2019 19;10:1272. Epub 2019 Jul 19.

Institute for Immunodeficiency, Center for Chronic Immunodeficiency (CCI), Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.

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http://dx.doi.org/10.3389/fimmu.2019.01272DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6659583PMC
October 2020

Daratumumab eradicates minimal residual disease in a preclinical model of pediatric T-cell acute lymphoblastic leukemia.

Blood 2019 08 16;134(8):713-716. Epub 2019 Jul 16.

Department of Pediatrics I, ALL-BFM Study Group, Christian-Albrechts University Kiel and University Medical Center Schleswig-Holstein, Kiel, Germany.

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http://dx.doi.org/10.1182/blood.2019000904DOI Listing
August 2019

Excessive Toxicity After Treatment of Congenital Acute Myeloid Leukemia.

Klin Padiatr 2019 11 18;231(6):291-293. Epub 2019 Mar 18.

Department of Pediatric Hematology, Oncology and Immunology, Children's Hospital, UniversitatsKlinikum Heidelberg, Heidelberg.

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http://dx.doi.org/10.1055/a-0859-7375DOI Listing
November 2019

β-Thalassemia Mutations in Jamaica: Geographic Variation in Small Communities.

Hemoglobin 2018 Sep - Nov;42(5-6):294-296. Epub 2019 Jan 9.

b Department of Paediatric Oncology, Haematology and Immunology , Heidelberg University , Heidelberg , Germany.

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https://www.tandfonline.com/doi/full/10.1080/03630269.2018.1
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http://dx.doi.org/10.1080/03630269.2018.1540354DOI Listing
May 2019

Expression of CD56 defines a distinct subgroup in childhood T-ALL with inferior outcome. Results of the ALL-BFM 2000 trial.

Br J Haematol 2018 10 20;183(1):96-103. Epub 2018 Jul 20.

Department of Haematology and Stem Cell Transplantation, Helios Klinikum Berlin Buch, Berlin, Germany.

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http://doi.wiley.com/10.1111/bjh.15503
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http://dx.doi.org/10.1111/bjh.15503DOI Listing
October 2018

Author Correction: The landscape of genomic alterations across childhood cancers.

Nature 2018 07;559(7714):E10

Hopp-Children's Cancer Center at the NCT Heidelberg (KiTZ), Heidelberg, Germany.

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http://dx.doi.org/10.1038/s41586-018-0167-2DOI Listing
July 2018

DNA methylation-based classification of central nervous system tumours.

Authors:
David Capper David T W Jones Martin Sill Volker Hovestadt Daniel Schrimpf Dominik Sturm Christian Koelsche Felix Sahm Lukas Chavez David E Reuss Annekathrin Kratz Annika K Wefers Kristin Huang Kristian W Pajtler Leonille Schweizer Damian Stichel Adriana Olar Nils W Engel Kerstin Lindenberg Patrick N Harter Anne K Braczynski Karl H Plate Hildegard Dohmen Boyan K Garvalov Roland Coras Annett Hölsken Ekkehard Hewer Melanie Bewerunge-Hudler Matthias Schick Roger Fischer Rudi Beschorner Jens Schittenhelm Ori Staszewski Khalida Wani Pascale Varlet Melanie Pages Petra Temming Dietmar Lohmann Florian Selt Hendrik Witt Till Milde Olaf Witt Eleonora Aronica Felice Giangaspero Elisabeth Rushing Wolfram Scheurlen Christoph Geisenberger Fausto J Rodriguez Albert Becker Matthias Preusser Christine Haberler Rolf Bjerkvig Jane Cryan Michael Farrell Martina Deckert Jürgen Hench Stephan Frank Jonathan Serrano Kasthuri Kannan Aristotelis Tsirigos Wolfgang Brück Silvia Hofer Stefanie Brehmer Marcel Seiz-Rosenhagen Daniel Hänggi Volkmar Hans Stephanie Rozsnoki Jordan R Hansford Patricia Kohlhof Bjarne W Kristensen Matt Lechner Beatriz Lopes Christian Mawrin Ralf Ketter Andreas Kulozik Ziad Khatib Frank Heppner Arend Koch Anne Jouvet Catherine Keohane Helmut Mühleisen Wolf Mueller Ute Pohl Marco Prinz Axel Benner Marc Zapatka Nicholas G Gottardo Pablo Hernáiz Driever Christof M Kramm Hermann L Müller Stefan Rutkowski Katja von Hoff Michael C Frühwald Astrid Gnekow Gudrun Fleischhack Stephan Tippelt Gabriele Calaminus Camelia-Maria Monoranu Arie Perry Chris Jones Thomas S Jacques Bernhard Radlwimmer Marco Gessi Torsten Pietsch Johannes Schramm Gabriele Schackert Manfred Westphal Guido Reifenberger Pieter Wesseling Michael Weller Vincent Peter Collins Ingmar Blümcke Martin Bendszus Jürgen Debus Annie Huang Nada Jabado Paul A Northcott Werner Paulus Amar Gajjar Giles W Robinson Michael D Taylor Zane Jaunmuktane Marina Ryzhova Michael Platten Andreas Unterberg Wolfgang Wick Matthias A Karajannis Michel Mittelbronn Till Acker Christian Hartmann Kenneth Aldape Ulrich Schüller Rolf Buslei Peter Lichter Marcel Kool Christel Herold-Mende David W Ellison Martin Hasselblatt Matija Snuderl Sebastian Brandner Andrey Korshunov Andreas von Deimling Stefan M Pfister

Nature 2018 03 14;555(7697):469-474. Epub 2018 Mar 14.

Hopp Children's Cancer Center at the NCT Heidelberg (KiTZ), Heidelberg, Germany.

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http://dx.doi.org/10.1038/nature26000DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6093218PMC
March 2018

IKZF1 Defines a New Minimal Residual Disease-Dependent Very-Poor Prognostic Profile in Pediatric B-Cell Precursor Acute Lymphoblastic Leukemia.

J Clin Oncol 2018 04 2;36(12):1240-1249. Epub 2018 Mar 2.

Martin Stanulla, Elif Dagdan, Stefanie V. Junk, Laura Hinze, Norman Klein, Christian P. Kratz, Petra Dörge, Doris Steinemann, and Martin Zimmermann, Hannover Medical School; Petra Dörge, German Center for Infection Research, Hannover; Anja Möricke, Kirsten Bleckmann, Denis Schewe, Gunnar Cario, and Martin Schrappe, University Hospital Schleswig-Holstein; Britt-Sabina Petersen and Andre Franke, Kiel University, Kiel; Cornelia Eckert and Stefanie Groeneveld-Krentz, Charité University Hospital; Wolf-Dieter Ludwig, HELIOS-Clinic Berlin-Buch, Berlin; Rolf Koehler, Claus R. Bartram, Andreas Kulozik, and Martina U. Muckenthaler, University of Heidelberg, Heidelberg; Arndt Borkhardt, Heinrich-Heine University, Düsseldorf, Germany; Marketa Zaliova, Charles University and University Hospital Motol, Prague, Czech Republic; Chiara Palmi, Giovanni Cazzaniga, and Andrea Biondi, Azienda Ospedaliera San Gerardo; Maria Grazia Valsecchi, University of Milano-Bicocca, Monza; Geertruy te Kronnie and Giuseppe Basso, University of Padova, Padua, Italy; Jean-Pierre Bourquin and Beat Bornhauser, University Children's Hospital Zurich, Zurich, Switzerland; Shai Izraeli, Sheba Medical Center Tel-Hashomer and Tel Aviv University, Tel Aviv, Israel; Oskar A. Haas and Renate Panzer-Grümayer, St Anna Kinderkrebsforschung and Medical University Vienna, Vienna, Austria; Hélène Cavé, Robert Debré Hospital and Paris-Diderot University, Paris, France; and Richard S. Houlston, The Institute of Cancer Research, London, United Kingdom.

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http://dx.doi.org/10.1200/JCO.2017.74.3617DOI Listing
April 2018

The landscape of genomic alterations across childhood cancers.

Nature 2018 03 28;555(7696):321-327. Epub 2018 Feb 28.

Hopp-Children's Cancer Center at the NCT Heidelberg (KiTZ), Heidelberg, Germany.

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http://dx.doi.org/10.1038/nature25480DOI Listing
March 2018

Dual function of UPF3B in early and late translation termination.

EMBO J 2017 10 12;36(20):2968-2986. Epub 2017 Sep 12.

Department of Pediatric Oncology, Hematology and Immunology, University of Heidelberg, Heidelberg, Germany

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http://dx.doi.org/10.15252/embj.201797079DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5641913PMC
October 2017

Haematological malignancies following temozolomide treatment for paediatric high-grade glioma.

Eur J Cancer 2017 08 3;81:1-8. Epub 2017 Jun 3.

Division of Pediatric Hematology and Oncology, Department of Child and Adolescent Health, University Medical Center Göttingen, Göttingen, Germany.

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http://dx.doi.org/10.1016/j.ejca.2017.04.023DOI Listing
August 2017

[Newborn Screening on Cystic Fibrosis in Germany: Comparison of the new Screening Protocol with an Alternative Protocol].

Klin Padiatr 2017 Mar 25;229(2):59-66. Epub 2017 Apr 25.

Sektion für Pädiatrische Pneumologie & Allergologie und Mukoviszidose-Zentrum, Zentrum für Kinder- und Jugendmedizin, Universitätsklinikum Heidelberg.

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http://dx.doi.org/10.1055/s-0042-124187DOI Listing
March 2017

The epidemiology of sickle cell disease in Germany following recent large-scale immigration.

Pediatr Blood Cancer 2017 Jul 6;64(7). Epub 2017 Apr 6.

Department of Pediatric Oncology, Hematology and Immunology, University of Heidelberg, Heidelberg, Germany.

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http://dx.doi.org/10.1002/pbc.26550DOI Listing
July 2017

Childhood cancer predisposition syndromes-A concise review and recommendations by the Cancer Predisposition Working Group of the Society for Pediatric Oncology and Hematology.

Am J Med Genet A 2017 Apr 7;173(4):1017-1037. Epub 2017 Feb 7.

Pediatric Hematology and Oncology, Hannover Medical School, Hannover, Germany.

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http://dx.doi.org/10.1002/ajmg.a.38142DOI Listing
April 2017

Insights into the design and interpretation of iCLIP experiments.

Genome Biol 2017 01 16;18(1). Epub 2017 Jan 16.

Department of Molecular Neuroscience, UCL Institute of Neurology, Queen Square, London, WC1N 3BG, UK.

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http://dx.doi.org/10.1186/s13059-016-1130-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5240381PMC
January 2017

Newborn screening for severe combined immunodeficiency using a novel and simplified method to measure T-cell excision circles (TREC).

Clin Immunol 2017 02 2;175:51-55. Epub 2016 Dec 2.

Department of Pediatric Oncology, Hematology and Immunology, Children's Hospital, University of Heidelberg, Heidelberg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.clim.2016.11.016DOI Listing
February 2017

Muscle strength and quality of life in patients with childhood cancer at early phase of primary treatment.

Pediatr Hematol Oncol 2016 Sep 3;33(6):393-407. Epub 2016 Oct 3.

f Department of Medical Oncology , National Center for Tumor Diseases and Heidelberg University Hospital , Heidelberg , Germany.

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http://dx.doi.org/10.1080/08880018.2016.1219796DOI Listing
September 2016

Next-generation personalised medicine for high-risk paediatric cancer patients - The INFORM pilot study.

Eur J Cancer 2016 09 29;65:91-101. Epub 2016 Jul 29.

Department of Pediatric Oncology, Hematology & Immunology, Heidelberg University Hospital, Im Neuenheimer Feld 430, Heidelberg, 69120, Germany; German Cancer Consortium (DKTK), Im Neuenheimer Feld 280, Heidelberg, 69120, Germany; Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg, 69120, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.ejca.2016.06.009DOI Listing
September 2016

Exon Junction Complexes Show a Distributional Bias toward Alternatively Spliced mRNAs and against mRNAs Coding for Ribosomal Proteins.

Cell Rep 2016 08 28;16(6):1588-1603. Epub 2016 Jul 28.

Department of Pediatric Oncology, Hematology, and Immunology, University of Heidelberg, Im Neuenheimer Feld 430, 69120 Heidelberg, Germany; Molecular Medicine Partnership Unit (MMPU), Im Neuenheimer Feld 350, 69120 Heidelberg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2016.06.096DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4978704PMC
August 2016

The differential expression of alternatively polyadenylated transcripts is a common stress-induced response mechanism that modulates mammalian mRNA expression in a quantitative and qualitative fashion.

RNA 2016 09 12;22(9):1441-53. Epub 2016 Jul 12.

Molecular Medicine Partnership Unit (MMPU), Heidelberg 69120, Germany Department of Pediatric Oncology, Hematology and Immunology, University of Heidelberg, Heidelberg 69120, Germany.

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http://dx.doi.org/10.1261/rna.055657.115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4986898PMC
September 2016

Proteomic Analysis Reveals Branch-specific Regulation of the Unfolded Protein Response by Nonsense-mediated mRNA Decay.

Mol Cell Proteomics 2016 05 20;15(5):1584-97. Epub 2016 Feb 20.

From the ‡Molecular Medicine Partnership Unit, European Molecular Biology Laboratory, University of Heidelberg, Heidelberg, Germany; §Department of Pediatric Oncology, Hematology and Immunology, University of Heidelberg, Heidelberg, Germany;

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http://dx.doi.org/10.1074/mcp.M115.054056DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4858941PMC
May 2016

Significant prevalence of sickle cell disease in Southwest Germany: results from a birth cohort study indicate the necessity for newborn screening.

Ann Hematol 2016 Feb 12;95(3):397-402. Epub 2015 Dec 12.

Department of Pediatric Oncology, Hematology, Oncology and Immunology, University of Heidelberg, Im Neuenheimer Feld 430, D-69120, Heidelberg, Germany.

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http://dx.doi.org/10.1007/s00277-015-2573-yDOI Listing
February 2016

HIV-1 Recruits UPF1 but Excludes UPF2 to Promote Nucleocytoplasmic Export of the Genomic RNA.

Biomolecules 2015 Oct 20;5(4):2808-39. Epub 2015 Oct 20.

HIV-1 RNA Trafficking Laboratory, Lady Davis Institute for Medical Research-Sir Mortimer B. Davis Jewish General Hospital, Montréal QC H3T 1E2, Canada.

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http://dx.doi.org/10.3390/biom5042808DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4693258PMC
October 2015

Improved binding site assignment by high-resolution mapping of RNA-protein interactions using iCLIP.

Nat Commun 2015 Aug 11;6:7921. Epub 2015 Aug 11.

Department of Pediatric Oncology, Hematology and Immunology, University of Heidelberg, Im Neuenheimer Feld 430, 69120 Heidelberg, Germany.

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http://dx.doi.org/10.1038/ncomms8921DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4918375PMC
August 2015

A network of SMG-8, SMG-9 and SMG-1 C-terminal insertion domain regulates UPF1 substrate recruitment and phosphorylation.

Nucleic Acids Res 2015 Sep 30;43(15):7600-11. Epub 2015 Jun 30.

European Molecular Biology Laboratory, Grenoble Outstation, 71 Avenue des Martyrs, 38042 Grenoble, France Unit of Virus Host-Cell Interactions, University Grenoble Alpes-EMBL-CNRS, UMI 3265, 71 Avenue des Martyrs, 38042 Grenoble, France School of Biochemistry, University of Bristol, Bristol, BS8 1TD, UK

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http://dx.doi.org/10.1093/nar/gkv668DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4551919PMC
September 2015

Haemoglobin Variant Screening in Jamaica: Meeting Student's Request.

Br J Haematol 2016 Feb 30;172(4):634-6. Epub 2015 Jun 30.

Sickle Cell Trust (Jamaica), Southern Regional Health Authority, Mandeville, Jamaica.

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http://dx.doi.org/10.1111/bjh.13531DOI Listing
February 2016

Five years of experience with biochemical cystic fibrosis newborn screening based on IRT/PAP in Germany.

Pediatr Pulmonol 2015 Jul 23;50(7):655-64. Epub 2015 Apr 23.

Division of Pediatric Pulmonology & Allergy and Cystic Fibrosis Center, Department of Pediatrics III, University of Heidelberg, Im Neuenheimer Feld 430, D-69120, Heidelberg, Germany.

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http://dx.doi.org/10.1002/ppul.23190DOI Listing
July 2015

The best of 25 years: mRNA 3'end processing.

RNA 2015 Apr;21(4):640-1

Department of Pediatric Oncology, Hematology and Immunology, University of Heidelberg, 69120 Heidelberg, Germany Molecular Medicine Partnership Unit (MMPU), 69117 Heidelberg, Germany

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http://dx.doi.org/10.1261/rna.050062.115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4371314PMC
April 2015

Treatment tolerance of particle therapy in pediatric patients.

Acta Oncol 2015 Jul 23;54(7):1049-55. Epub 2015 Jan 23.

Department of Radiation Oncology, University Hospital Heidelberg , Heidelberg , Germany.

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http://dx.doi.org/10.3109/0284186X.2014.998273DOI Listing
July 2015

The thrombopoietin receptor P106L mutation functionally separates receptor signaling activity from thrombopoietin homeostasis.

Blood 2015 Feb 23;125(7):1159-69. Epub 2014 Dec 23.

Department of Pediatric Oncology, Hematology and Immunology, University of Heidelberg, Heidelberg, Germany.

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http://dx.doi.org/10.1182/blood-2014-07-587170DOI Listing
February 2015

5-azacytidine inhibits nonsense-mediated decay in a MYC-dependent fashion.

EMBO Mol Med 2014 Dec;6(12):1593-609

Molecular Medicine Partnership Unit, European Molecular Biology Laboratory, University of Heidelberg, Heidelberg, Germany Department of Pediatric Oncology, Hematology and Immunology, University of Heidelberg, Heidelberg, Germany

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http://dx.doi.org/10.15252/emmm.201404461DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4287977PMC
December 2014

Enhancer hijacking activates GFI1 family oncogenes in medulloblastoma.

Nature 2014 Jul 22;511(7510):428-34. Epub 2014 Jun 22.

1] Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany [2] Department of Pediatric Oncology, Hematology & Immunology, Heidelberg University Hospital, Im Neuenheimer Feld 430, Heidelberg 69120, Germany.

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http://www.abta.org/resources/enhancers-hijacking-activates.
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http://www.nature.com/doifinder/10.1038/nature13379
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http://dx.doi.org/10.1038/nature13379DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4201514PMC
July 2014

Novel activating mutations lacking cysteine in type I cytokine receptors in acute lymphoblastic leukemia.

Blood 2014 Jul 1;124(1):106-10. Epub 2014 May 1.

Childhood Leukemia Research Institute, Edmond and Lily Safra Children Hospital, Sheba Medical Center, Ramat Gan, Israel; Human Molecular Genetics and Biochemistry, Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel;

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http://dx.doi.org/10.1182/blood-2013-10-529685DOI Listing
July 2014

Genome sequencing of SHH medulloblastoma predicts genotype-related response to smoothened inhibition.

Cancer Cell 2014 Mar;25(3):393-405

Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), 69121 Heidelberg, Germany; Department of Pediatric Oncology, Hematology and Immunology, University Hospital Heidelberg, 69120 Heidelberg, Germany.

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http://dx.doi.org/10.1016/j.ccr.2014.02.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4493053PMC
March 2014

GRHL1 acts as tumor suppressor in neuroblastoma and is negatively regulated by MYCN and HDAC3.

Cancer Res 2014 May 13;74(9):2604-16. Epub 2014 Jan 13.

Authors' Affiliations: Clinical Cooperation Unit Pediatric Oncology; Departments of Biostatistics and Tumor Genetics; Clinical Cooperation Unit Neuropathology; Division of Epigenomics and Cancer Risk Factors, German Cancer Research Center (DKFZ); Departments of Neuropathology and Pediatric Hematology and Oncology, University of Heidelberg, Heidelberg; Transcriptome Analysis Laboratory, University of Goettingen, Goettingen; St. Lukas Klinik Solingen, Solingen; Department of Pediatric Hematology and Oncology; and Center for Molecular Medicine Cologne, University of Cologne, Cologne, Germany.

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http://dx.doi.org/10.1158/0008-5472.CAN-13-1904DOI Listing
May 2014

mRNA 3'end processing: A tale of the tail reaches the clinic.

EMBO Mol Med 2014 01;6(1):16-26

Department of Pediatric Oncology, Hematology and Immunology, University of Heidelberg, Heidelberg, Germany.

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http://dx.doi.org/10.1002/emmm.201303300DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3936486PMC
January 2014

Pathologies at the nexus of blood coagulation and inflammation: thrombin in hemostasis, cancer, and beyond.

J Mol Med (Berl) 2013 Nov 17;91(11):1257-71. Epub 2013 Aug 17.

Department of Pediatric Oncology, Hematology and Immunology, University of Heidelberg, Heidelberg, Germany,

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http://link.springer.com/10.1007/s00109-013-1074-5
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http://dx.doi.org/10.1007/s00109-013-1074-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3825489PMC
November 2013

Two mammalian MAGOH genes contribute to exon junction complex composition and nonsense-mediated decay.

RNA Biol 2013 Aug 23;10(8):1291-8. Epub 2013 Jul 23.

University of Cologne; Institute for Genetics; Cologne, Germany.

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http://dx.doi.org/10.4161/rna.25827DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3817150PMC
August 2013

Comparison of different IRT-PAP protocols to screen newborns for cystic fibrosis in three central European populations.

J Cyst Fibros 2014 Jan 25;13(1):15-23. Epub 2013 Jul 25.

Translational Lung Research Centre Heidelberg (TLRC), Member of the German Center for Lung Research (DZL), Im Neuenheimer Feld 350, D-69120 Heidelberg, Germany; Division of Metabolic Diseases and Newborn Screening Center, Department of Paediatrics I, Children's Hospital, University of Heidelberg, Im Neuenheimer Feld 430, D-69120 Heidelberg, Germany.

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http://dx.doi.org/10.1016/j.jcf.2013.06.003DOI Listing
January 2014

Recurrent somatic alterations of FGFR1 and NTRK2 in pilocytic astrocytoma.

Nat Genet 2013 Aug 30;45(8):927-32. Epub 2013 Jun 30.

Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Heidelberg, Germany.

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http://pubman.mpdl.mpg.de/pubman/item/escidoc:1982973/compon
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http://www.nature.com/doifinder/10.1038/ng.2682
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http://dx.doi.org/10.1038/ng.2682DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3951336PMC
August 2013

Outcomes of treatment for relapsed acute lymphoblastic leukaemia in children with Down syndrome.

Br J Haematol 2013 Jul 18;162(1):98-106. Epub 2013 Apr 18.

Paediatric Haematology/Oncology, Charité-Universitätsmedizin Berlin, Augustenburger Platz 1, Berlin, Germany.

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http://dx.doi.org/10.1111/bjh.12348DOI Listing
July 2013

Whole-exome sequencing links caspase recruitment domain 11 (CARD11) inactivation to severe combined immunodeficiency.

J Allergy Clin Immunol 2013 May 3;131(5):1376-83.e3. Epub 2013 Apr 3.

Department of Pediatric Oncology, Hematology and Immunology, University of Heidelberg, Heidelberg, Germany.

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http://dx.doi.org/10.1016/j.jaci.2013.02.012DOI Listing
May 2013

Hotspot mutations in H3F3A and IDH1 define distinct epigenetic and biological subgroups of glioblastoma.

Cancer Cell 2012 Oct;22(4):425-37

Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) Heidelberg, 69120 Heidelberg, Germany.

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http://dx.doi.org/10.1016/j.ccr.2012.08.024DOI Listing
October 2012

Dissecting the genomic complexity underlying medulloblastoma.

Nature 2012 Aug;488(7409):100-5

Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany.

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http://dx.doi.org/10.1038/nature11284DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3662966PMC
August 2012

Nestin expression identifies ependymoma patients with poor outcome.

Brain Pathol 2012 Nov 30;22(6):848-60. Epub 2012 May 30.

Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center, Heidelberg, Germany.

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http://dx.doi.org/10.1111/j.1750-3639.2012.00600.xDOI Listing
November 2012

Hereditary thrombocythemia caused by a thrombopoietin (THPO) gain-of-function mutation associated with multiple myeloma and congenital limb defects.

Ann Hematol 2012 Jul 28;91(7):1129-33. Epub 2012 Mar 28.

Department of Pediatric Oncology, Hematology and Immunology, University of Heidelberg, Im Neuenheimer Feld 430, 69120, Heidelberg, Germany.

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http://dx.doi.org/10.1007/s00277-012-1453-yDOI Listing
July 2012