Dr. Andreas I Papadakis, PhD - McGill University

Dr. Andreas I Papadakis

PhD

McGill University

Canada

Dr. Andreas I Papadakis, PhD - McGill University

Dr. Andreas I Papadakis

PhD

Introduction

Primary Affiliation: McGill University - Canada

Publications

15Publications

306Reads

-Profile Views

214PubMed Central Citations

The eIF2α serine 51 phosphorylation-ATF4 arm promotes HIPPO signaling and cell death under oxidative stress.

Oncotarget 2016 08;7(32):51044-51058

Lady Davis Institute for Medical Research, McGill University, Sir Mortimer B. Davis-Jewish General Hospital, Montreal, Quebec, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.18632/oncotarget.10480DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5239457PMC
August 2016
23 Reads
2 Citations
6.360 Impact Factor

The Human Adenovirus Type 5 E4orf4 Protein Targets Two Phosphatase Regulators of the Hippo Signaling Pathway.

J Virol 2015 Sep 17;89(17):8855-70. Epub 2015 Jun 17.

Department of Biochemistry, McGill University, Montreal, Québec, Canada The Rosalind and Morris Goodman Cancer Research Centre, McGill University, Montreal, Québec, Canada Department of Oncology, McGill University, Montreal, Québec, Canada

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/JVI.03710-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4524087PMC
September 2015
22 Reads
4.440 Impact Factor

Evidence for eIF2α phosphorylation-independent effects of GSK2656157, a novel catalytic inhibitor of PERK with clinical implications.

Cell Cycle 2014 8;13(5):801-6. Epub 2014 Jan 8.

Lady Davis Institute for Medical Research; McGill University; Sir Mortimer B. Davis-Jewish General Hospital; Montreal, Quebec, Canada; Department of Oncology; Faculty of Medicine; McGill University; Montreal, Quebec, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4161/cc.27726DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3979916PMC
May 2015
12 Reads
8 Citations

SMARCE1 suppresses EGFR expression and controls responses to MET and ALK inhibitors in lung cancer.

Cell Res 2015 Apr 6;25(4):445-58. Epub 2015 Feb 6.

Department of Biochemistry, The Rosalind and Morris Goodman Cancer Centre, McGill University, Montreal, QC H3G 1Y6, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/cr.2015.16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4387553PMC
April 2015
8 Reads
9 Citations
12.413 Impact Factor

Phosphorylation of the translation initiation factor eIF2α at serine 51 determines the cell fate decisions of Akt in response to oxidative stress.

Cell Death Dis 2015 Jan 15;6:e1591. Epub 2015 Jan 15.

1] Lady Davis Institute for Medical Research, McGill University, Sir Mortimer B. Davis-Jewish General Hospital, Montreal, Quebec, Canada H3T 1E2 [2] Department of Oncology, Faculty of Medicine, McGill University, Montreal, Quebec, Canada H2W 1S6.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/cddis.2014.554DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4669752PMC
January 2015
9 Reads
25 Citations
5.014 Impact Factor

eIF2α phosphorylation bypasses premature senescence caused by oxidative stress and pro-oxidant antitumor therapies.

Aging (Albany NY) 2013 Dec;5(12):884-901

Lady Davis Institute for Medical Research, McGill University, Sir Mortimer B. Davis-Jewish General Hospital, Montreal, Quebec H3T 1E2, Canada.

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3883705PMC
http://dx.doi.org/10.18632/aging.100620DOI Listing
December 2013
3 Reads
9 Citations
6.432 Impact Factor

Development of transgenic mice expressing a conditionally active form of the eIF2α kinase PKR.

Genesis 2011 Sep 18;49(9):743-9. Epub 2011 Aug 18.

Lady Davis Institute for Medical Research, McGill University, Sir Mortimer B. Davis-Jewish General Hospital, Montreal, Quebec H3T 1E2, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/dvg.20749DOI Listing
September 2011
5 Reads
1 Citation

Doxorubicin bypasses the cytoprotective effects of eIF2α phosphorylation and promotes PKR-mediated cell death.

Cell Death Differ 2011 Jan 18;18(1):145-54. Epub 2010 Jun 18.

Lady Davis Institute for Medical Research, Sir Mortimer B Davis-Jewish General Hospital, Montreal, Quebec, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/cdd.2010.76DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3131862PMC
January 2011
8 Reads
19 Citations
8.184 Impact Factor

HDAC pharmacological inhibition promotes cell death through the eIF2α kinases PKR and GCN2.

Aging (Albany NY) 2010 Oct;2(10):669-77

Lady Davis Institute for Medical Research, Sir Mortimer B. Davis-Jewish General Hospital, Montreal, Quebec, Canada.

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2993797PMC
http://dx.doi.org/10.18632/aging.100216DOI Listing
October 2010
5 Reads
5 Citations
6.432 Impact Factor

eIF2{alpha} Kinase PKR modulates the hypoxic response by Stat3-dependent transcriptional suppression of HIF-1{alpha}.

Cancer Res 2010 Oct 5;70(20):7820-9. Epub 2010 Oct 5.

Lady Davis Institute for Medical Research, McGill University, Sir Mortimer B. Davis-Jewish General Hospital, Montreal, Quebec, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/0008-5472.CAN-10-0215DOI Listing
October 2010
11 Reads
12 Citations
9.330 Impact Factor

Phosphorylation of eIF2α at serine 51 is an important determinant of cell survival and adaptation to glucose deficiency.

Mol Biol Cell 2010 Sep 21;21(18):3220-31. Epub 2010 Jul 21.

Lady Davis Institute for Medical Research, Sir Mortimer B. Davis-Jewish General Hospital, Montreal, QC, H3T 1E2, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1091/mbc.E10-01-0023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2938387PMC
September 2010
19 Reads
34 Citations
4.470 Impact Factor

PKR and PKR-like endoplasmic reticulum kinase induce the proteasome-dependent degradation of cyclin D1 via a mechanism requiring eukaryotic initiation factor 2alpha phosphorylation.

J Biol Chem 2008 Feb 6;283(6):3097-108. Epub 2007 Dec 6.

Department of Oncology, Faculty of Medicine, McGill University, Montreal, Quebec H2W 1S6, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M709677200DOI Listing
February 2008
4 Reads
40 Citations
4.573 Impact Factor

The eIF2alpha kinases PERK and PKR activate glycogen synthase kinase 3 to promote the proteasomal degradation of p53.

J Biol Chem 2007 Oct 4;282(43):31675-87. Epub 2007 Sep 4.

Lady Davis Institute for Medical Research, McGill University, Sir Mortimer B. Davis-Jewish General Hospital, Montreal, Quebec H3T 1E2, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M704491200DOI Listing
October 2007
11 Reads
38 Citations
4.573 Impact Factor