Andrea Velardi

Andrea Velardi

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Andrea Velardi

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T cell depletion and no post transplant immune suppression allow separation of graft versus leukemia from graft versus host disease.

Bone Marrow Transplant 2019 Aug;54(Suppl 2):775-779

Blood and Marrow Transplantation Program, Division of Hematology and Clinical Immunology, Department of Medicine, University of Perugia, Perugia, Italy.

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http://dx.doi.org/10.1038/s41409-019-0597-yDOI Listing
August 2019

The "ultimate" haploidentical transplantation for the elderly with high-risk acute myeloid leukemia.

Bone Marrow Transplant 2019 Aug;54(Suppl 2):803-805

Hematopoietic Stem Cell Transplantation Program, Division of Hematology and Clinical Immunology, Department of Medicine, University of Perugia, Perugia, Italy.

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http://dx.doi.org/10.1038/s41409-019-0618-xDOI Listing
August 2019

TNFR2 signaling modulates immunity after allogeneic hematopoietic cell transplantation.

Cytokine Growth Factor Rev 2019 Jun 15;47:54-61. Epub 2019 May 15.

Hematology and Clinical Immunology and Bone Marrow Transplant Program, Department of Medicine, University of Perugia, Perugia, 06132, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.cytogfr.2019.05.001DOI Listing
June 2019

The Effect of TNF-α on Regulatory T Cell Function in Graft-versus-Host Disease.

Front Immunol 2018 28;9:356. Epub 2018 Feb 28.

Hematology and Clinical Immunology and Bone Marrow Transplant Program, Department of Medicine, University of Perugia, Perugia, Italy.

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http://dx.doi.org/10.3389/fimmu.2018.00356DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5835761PMC
April 2019

Clinical-Grade-Expanded Regulatory T Cells Prevent Graft-versus-Host Disease While Allowing a Powerful T Cell-Dependent Graft-versus-Leukemia Effect in Murine Models.

Biol Blood Marrow Transplant 2017 Nov 17;23(11):1847-1851. Epub 2017 Jul 17.

Department of Hematology, Transfusion Medicine and Biotechnologies, Ospedale Civile, Pescara, Italy; Department of Medicine and Aging Sciences, University of Chieti-Pescara, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.bbmt.2017.07.009DOI Listing
November 2017

Identifying NK Alloreactive Donors for Haploidentical Hematopoietic Stem Cell Transplantation.

Methods Mol Biol 2016 ;1393:141-5

Division of Hematology and Clinical Immunology, Department of Medicine, University of Perugia, Perugia, Italy.

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http://dx.doi.org/10.1007/978-1-4939-3338-9_14DOI Listing
December 2016

Haploidentical hematopoietic transplantation for the cure of leukemia: from its biology to clinical translation.

Blood 2016 12 3;128(23):2616-2623. Epub 2016 Oct 3.

Division of Hematology and Clinical Immunology, Department of Medicine, University of Perugia, Perugia, Italy.

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http://dx.doi.org/10.1182/blood-2016-07-730564DOI Listing
December 2016

The Total Body Irradiation Schedule Affects Acute Leukemia Relapse After Matched T Cell-Depleted Hematopoietic Stem Cell Transplantation.

Int J Radiat Oncol Biol Phys 2016 11 27;96(4):832-839. Epub 2016 Jul 27.

Division of Hematology and Clinical Immunology and Bone Marrow Transplant Program, Department of Medicine, Perugia General Hospital and University, Perugia, Italy.

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http://dx.doi.org/10.1016/j.ijrobp.2016.07.025DOI Listing
November 2016

Effects of anti-NKG2A antibody administration on leukemia and normal hematopoietic cells.

Haematologica 2016 05 31;101(5):626-33. Epub 2015 Dec 31.

Division of Hematology and Clinical Immunology and Bone Marrow Transplantation Program, Department of Medicine, University of Perugia, Italy.

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http://dx.doi.org/10.3324/haematol.2015.135301DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5004363PMC
May 2016

New mechanism of lymphoma-induced bone marrow aplasia.

Ann Hematol 2016 May 9;95(6):1013-5. Epub 2016 Mar 9.

Division of Hematology and Clinical Immunology, Department of Medicine, University of Perugia, Perugia, Italy.

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http://link.springer.com/10.1007/s00277-016-2632-z
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http://dx.doi.org/10.1007/s00277-016-2632-zDOI Listing
May 2016

Differences in Aspergillus-specific immune recovery between T-cell-replete and T-cell-depleted hematopoietic transplants.

Eur J Haematol 2015 Dec 16;95(6):551-7. Epub 2015 Mar 16.

Pediatric Hematology Oncology, Azienda Ospedaliera Universitaria Integrata, Verona, Italy.

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http://dx.doi.org/10.1111/ejh.12531DOI Listing
December 2015

Haploidentical hematopoietic stem cell transplantation: step-by-step progress.

Authors:
Andrea Velardi

Biol Blood Marrow Transplant 2015 Apr 11;21(4):579-80. Epub 2015 Feb 11.

Blood and Marrow Transplant Program, Division of Hematology and Clinical Immunology, University of Perugia, Perugia, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.bbmt.2015.02.004DOI Listing
April 2015

The cross-talk between opportunistic fungi and the mammalian host via microbiota's metabolism.

Semin Immunopathol 2015 Mar 18;37(2):163-71. Epub 2014 Nov 18.

Department of Experimental Medicine, University of Perugia, Polo Unico Sant'Andrea delle Fratte, 06132, Perugia, Italy,

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http://dx.doi.org/10.1007/s00281-014-0464-2DOI Listing
March 2015

HLA-C expression levels define permissible mismatches in hematopoietic cell transplantation.

Blood 2014 Dec 16;124(26):3996-4003. Epub 2014 Oct 16.

Cancer and Inflammation Program, SAIC Frederick, Inc., Frederick National Laboratories for Cancer Research, Frederick, MD; and Ragon Institute of the Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Boston, MA.

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http://dx.doi.org/10.1182/blood-2014-09-599969DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4271183PMC
December 2014

"Designed" grafts for HLA-haploidentical stem cell transplantation.

Blood 2014 Feb 20;123(7):967-73. Epub 2013 Dec 20.

Hematology and Clinical Immunology Section, Department of Clinical and Experimental Medicine, University of Perugia, Italy;

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http://dx.doi.org/10.1182/blood-2013-10-531764DOI Listing
February 2014

Haplo-BMT: which approach?

Authors:
Andrea Velardi

Blood 2013 Jan;121(5):719-20

University of Perugia.

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http://dx.doi.org/10.1182/blood-2012-12-469981DOI Listing
January 2013

Haploidentical hematopoietic stem cell transplantation with a megadose T-cell-depleted graft: harnessing natural and adaptive immunity.

Semin Oncol 2012 Dec;39(6):643-52

Section of Hematology and BMT Unit, University of Parma, Parma, Italy.

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http://dx.doi.org/10.1053/j.seminoncol.2012.09.002DOI Listing
December 2012

Natural killer cell alloreactivity 10 years later.

Authors:
Andrea Velardi

Curr Opin Hematol 2012 Nov;19(6):421-6

Division of Hematology and Clinical Immunology, Department of Clinical and Experimental Medicine, University of Perugia, Perugia, Italy.

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http://dx.doi.org/10.1097/MOH.0b013e3283590395DOI Listing
November 2012

An overview of methods required to evaluate donor NK cell alloreactivity for haploidentical haemopoietic stem cell transplantation.

Authors:
Andrea Velardi

Methods Mol Biol 2012 ;882:469-76

Division of Haematology and Clinical Immunology, Department of Clinical and Experimental Medicine, University of Perugia, Ospedale Santa Maria della Misericordia, Perugia, Italy.

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http://dx.doi.org/10.1007/978-1-61779-842-9_26DOI Listing
October 2012

Jack of all trades: thymosin α1 and its pleiotropy.

Ann N Y Acad Sci 2012 Oct;1269:1-6

Department of Experimental Medicine and Biochemical Science, University of Perugia, Perugia, Italy.

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http://doi.wiley.com/10.1111/j.1749-6632.2012.06716.x
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http://dx.doi.org/10.1111/j.1749-6632.2012.06716.xDOI Listing
October 2012

Killer-cell immunoglobulin-like receptors reactivity and outcome of stem cell transplant.

Curr Opin Hematol 2012 Jul;19(4):319-23

Division of Hematology and Clinical Immunology, Department of Clinical and Experimental Medicine, University of Perugia, Perugia, Italy.

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http://dx.doi.org/10.1097/MOH.0b013e32835423c3DOI Listing
July 2012

Effect of T-cell-epitope matching at HLA-DPB1 in recipients of unrelated-donor haemopoietic-cell transplantation: a retrospective study.

Lancet Oncol 2012 Apr 15;13(4):366-74. Epub 2012 Feb 15.

Unit of Molecular and Functional Immunogenetics, Division of Regenerative Medicine, Stem Cells and Gene Therapy, Istituto di Ricovero e Cura a Carattere Scientifico H San Raffaele, Milan, Italy.

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http://dx.doi.org/10.1016/S1470-2045(12)70004-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3813000PMC
April 2012

Natural revenge over cytomegalovirus.

Authors:
Andrea Velardi

Blood 2012 Mar;119(11):2438-9

University of Perugia, Perugia, Italy.

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http://dx.doi.org/10.1182/blood-2012-01-400739DOI Listing
March 2012

Immunoselection and clinical use of T regulatory cells in HLA-haploidentical stem cell transplantation.

Best Pract Res Clin Haematol 2011 Sep 29;24(3):459-66. Epub 2011 Jun 29.

Hematology and Clinical Immunology Section, Department of Clinical and Experimental Medicine, University of Perugia, Italy.

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http://dx.doi.org/10.1016/j.beha.2011.05.005DOI Listing
September 2011

Expansion of CD56-negative, CD16-positive, KIR-expressing natural killer cells after T cell-depleted haploidentical hematopoietic stem cell transplantation.

Acta Haematol 2011 17;126(1):13-20. Epub 2011 Mar 17.

Division of Hematology and Clinical Immunology, Department of Clinical and Experimental Medicine, University of Perugia, Perugia, Italy.

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http://dx.doi.org/10.1159/000323661DOI Listing
August 2011

Natural killer cell allorecognition of missing self in allogeneic hematopoietic transplantation: a tool for immunotherapy of leukemia.

Curr Opin Immunol 2009 Oct 28;21(5):525-30. Epub 2009 Aug 28.

Division of Haematology and Clinical Immunology, Department of Clinical and Experimental Medicine, University of Perugia, Ospedale Santa Maria della Misericordia, 06132 - Perugia, Italy.

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http://dx.doi.org/10.1016/j.coi.2009.07.015DOI Listing
October 2009

Clinical impact of natural killer cell reconstitution after allogeneic hematopoietic transplantation.

Semin Immunopathol 2008 Dec 11;30(4):489-503. Epub 2008 Nov 11.

Division of Hematology and Clinical Immunology, Department of Clinical and Experimental Medicine, University of Perugia, Ospedale Santa Maria della Misericordia, Perugia, Italy.

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http://dx.doi.org/10.1007/s00281-008-0136-1DOI Listing
December 2008

Role of KIRs and KIR ligands in hematopoietic transplantation.

Authors:
Andrea Velardi

Curr Opin Immunol 2008 Oct 23;20(5):581-7. Epub 2008 Aug 23.

Division of Haematology and Clinical Immunology, Department of Clinical and Experimental Medicine, University of Perugia, Ospedale Santa Maria della Misericordia, 06129 Perugia, Italy.

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http://dx.doi.org/10.1016/j.coi.2008.07.004DOI Listing
October 2008

Human leukocyte antigens A23, A24, and A32 but not A25 are ligands for KIR3DL1.

Blood 2008 Aug 23;112(3):708-10. Epub 2008 May 23.

Department of Hematology, University Hospital Basel, Basel, Switzerland.

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http://dx.doi.org/10.1182/blood-2008-02-137521DOI Listing
August 2008

Microparticles derived from endothelial progenitor cells in patients at different cardiovascular risk.

Atherosclerosis 2008 Apr 27;197(2):757-67. Epub 2007 Aug 27.

Unit of Internal Medicine, Angiology and Arteriosclerosis Diseases, Department of Clinical and Experimental Medicine, University of Perugia, Perugia, Italy.

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http://linkinghub.elsevier.com/retrieve/pii/S002191500700462
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http://dx.doi.org/10.1016/j.atherosclerosis.2007.07.012DOI Listing
April 2008

NK cell alloreactivity and allogeneic hematopoietic stem cell transplantation.

Blood Cells Mol Dis 2008 Jan-Feb;40(1):84-90. Epub 2007 Oct 26.

Department of Clinical and Experimental Medicine, IRCCS Foundation on Transplantation Biotechnologies, University of Perugia, Italy.

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http://linkinghub.elsevier.com/retrieve/pii/S107997960700143
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http://dx.doi.org/10.1016/j.bcmd.2007.06.029DOI Listing
February 2008

Photodynamic purging of alloreactive T cells for adoptive immunotherapy after haploidentical stem cell transplantation.

Blood Cells Mol Dis 2008 Jan-Feb;40(1):76-83. Epub 2007 Nov 5.

Department of Clinical and Experimental Medicine, IRCCS Foundation on Transplantation Biotechnologies, University of Perugia, Via Brunamonti 51, 06123, Italy.

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http://dx.doi.org/10.1016/j.bcmd.2007.06.022DOI Listing
February 2008

Hematopoietic stem cell transplantation from alternative donors for high-risk acute leukemia: the haploidentical option.

Curr Stem Cell Res Ther 2007 Jan;2(1):105-12

Hematopoietic Stem Cell Transplant Unit, Section of Hematology and Immunology, Department of Clinical and Experimental Medicine, University of Perugia, Perugia 06100, Italy.

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January 2007

Allogeneic hematopoietic transplantation and natural killer cell recognition of missing self.

Immunol Rev 2006 Dec;214:202-18

Division of Hematology and Clinical Immunology, Department of Clinical and Experimental Medicine, University of Perugia, Italy.

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http://dx.doi.org/10.1111/j.1600-065X.2006.00455.xDOI Listing
December 2006

Increased ratio of CD31+/CD42- microparticles to endothelial progenitors as a novel marker of atherosclerosis in hypercholesterolemia.

Arterioscler Thromb Vasc Biol 2006 Nov 31;26(11):2530-5. Epub 2006 Aug 31.

Department of Clinical and Experimental Medicine, University of Perugia, Italy.

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http://dx.doi.org/10.1161/01.ATV.0000243941.72375.15DOI Listing
November 2006

Natural killer cell recognition of missing self and haploidentical hematopoietic transplantation.

Semin Cancer Biol 2006 Oct 8;16(5):404-11. Epub 2006 Jul 8.

Division of Hematology and Clinical Immunology, Department of Clinical and Experimental Medicine, University of Perugia, Policlinico Monteluce, Via Brunamonti 51, Perugia, Italy.

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http://dx.doi.org/10.1016/j.semcancer.2006.07.007DOI Listing
October 2006

Toward the identification of a tolerogenic signature in IDO-competent dendritic cells.

Blood 2006 Apr 8;107(7):2846-54. Epub 2005 Dec 8.

Section of Pharmacology, Department of Experimental Medicine and Biochemical Sciences, University of Perugia, 06126 Perugia, Italy.

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http://dx.doi.org/10.1182/blood-2005-10-4077DOI Listing
April 2006

Transferring functional immune responses to pathogens after haploidentical hematopoietic transplantation.

Blood 2005 Dec 25;106(13):4397-406. Epub 2005 Aug 25.

Division of Hematology and Clinical Immunology, Department of Clinical and Experimental Medicine, University of Perugia, Policlinico Monteluce, Via Brunamonti 51-06122 Perugia, Italy.

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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2005-05-17
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http://dx.doi.org/10.1182/blood-2005-05-1775DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1895249PMC
December 2005

Natural killer cell alloreactivity for leukemia therapy.

J Immunother 2005 May-Jun;28(3):175-82

Division of Hematology and Clinical Immunology, Department of Clinical and Experimental Medicine, University of Perugia, 06122 Perugia, Italy.

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October 2005

The impact of donor natural killer cell alloreactivity on allogeneic hematopoietic transplantation.

Transpl Immunol 2005 Aug;14(3-4):203-6

Division of Haematology and Clinical Immunology, Department of Clinical and Experimental Medicine, University of Perugia, Italy.

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http://dx.doi.org/10.1016/j.trim.2005.03.008DOI Listing
August 2005

Alloreactive natural killer cells in mismatched hematopoietic stem cell transplantation.

Blood Cells Mol Dis 2004 Nov-Dec;33(3):216-21

Department of Clinical and Experimental Medicine, Haematology and Clinical Immunology, University of Perugia, Italy.

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http://dx.doi.org/10.1016/j.bcmd.2004.08.005DOI Listing
April 2005

Prospects for dendritic cell vaccination against fungal infections in hematopoietic transplantation.

Blood Cells Mol Dis 2004 Nov-Dec;33(3):248-55

Division of Hematology, Clinical Immunology, Department of Clinical and Experimental Medicine, University of Perugia, Perugia, Italy.

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http://dx.doi.org/10.1016/j.bcmd.2004.08.011DOI Listing
April 2005

Fourth International Workshop on Haploidentical Transplants, Naples, Italy, July 8-10, 2004.

Blood Cells Mol Dis 2004 Nov-Dec;33(3):159-75

Department of Clinical and Experimental Medicine, University of Perugia, Italy.

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April 2005

Exploitation of alloreactive NK cells in adoptive immunotherapy of cancer.

Curr Opin Immunol 2005 Apr;17(2):211-7

Division of Haematology and Clinical Immunology, Department of Clinical and Experimental Medicine, University of Perugia, Policlinico Monteluce, 06122 Perugia, Italy.

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http://dx.doi.org/10.1016/j.coi.2005.01.007DOI Listing
April 2005

Natural killer cell alloreactivity in haploidentical hematopoietic stem cell transplantation.

Int J Hematol 2005 Jan;81(1):13-7

Division of Haematology and Clinical Immunology, Department of Clinical and Experimental Medicine, University of Perugia, Perugia, Italy.

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January 2005

Natural killer cells as a therapeutic tool in mismatched transplantation.

Best Pract Res Clin Haematol 2004 Sep;17(3):427-38

Division of Haematology and Clinical Immunology, Department of Clinical and Experimental Medicine, University of Perugia, Policlinico Monteluce, Via Brunamonti 06100, Perugia, Italy.

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http://dx.doi.org/10.1016/j.beha.2004.05.010DOI Listing
September 2004

Thymosin alpha 1 activates dendritic cells for antifungal Th1 resistance through toll-like receptor signaling.

Blood 2004 Jun 24;103(11):4232-9. Epub 2004 Feb 24.

Department of Experimental Medicine and Biochemical Sciences Microbiology Section, University of Perugia, Via del Giochetto, 06122 Perugia, Italy.

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http://dx.doi.org/10.1182/blood-2003-11-4036DOI Listing
June 2004

A dendritic cell vaccine against invasive aspergillosis in allogeneic hematopoietic transplantation.

Blood 2003 Nov 5;102(10):3807-14. Epub 2003 Jun 5.

Microbiology Section, Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Via del Giochetto, 06122 Perugia, Italy.

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http://dx.doi.org/10.1182/blood-2003-03-0748DOI Listing
November 2003

Evaluation of KIR ligand incompatibility in mismatched unrelated donor hematopoietic transplants. Killer immunoglobulin-like receptor.

Blood 2002 Nov 5;100(10):3825-7. Epub 2002 Jul 5.

Blood and Marrow Transplant Program, University of Minnesota, Minneapolis 55455, USA.

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http://dx.doi.org/10.1182/blood-2002-04-1197DOI Listing
November 2002

NK cells: a lesson from mismatched hematopoietic transplantation.

Trends Immunol 2002 Sep;23(9):438-44

Dipartimento di Medicina Clinica e Sperimentale, Sezione di Ematologia e Immunologia Clinica, Università degli Studi di Perugia, Italy.

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September 2002

Natural killer cell receptors: new biology and insights into the graft-versus-leukemia effect.

Blood 2002 Sep;100(6):1935-47

Department of Internal Medicine, Division of Hematology/Oncology, The Ohio State University, A433A Starling Loving Hall, 320 W Tenth Avenue, Columbus, OH 43210, USA.

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http://dx.doi.org/10.1182/blood-2002-02-0350DOI Listing
September 2002

Dendritic cells pulsed with fungal RNA induce protective immunity to Candida albicans in hematopoietic transplantation.

J Immunol 2002 Mar;168(6):2904-13

Microbiology Section, Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy.

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http://dx.doi.org/10.4049/jimmunol.168.6.2904DOI Listing
March 2002

Effectiveness of donor natural killer cell alloreactivity in mismatched hematopoietic transplants.

Science 2002 Mar;295(5562):2097-100

Department of Clinical and Experimental Medicine, Section of Hematology and Clinical Immunology, Perugia University School of Medicine, Perugia, Italy.

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http://dx.doi.org/10.1126/science.1068440DOI Listing
March 2002

Transplants across human leukocyte antigen barriers.

Semin Hematol 2002 Jan;39(1):48-56

Department of Hematology, University of Perugia, Perugia, Italy.

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January 2002