Andrea Sottoriva

Andrea Sottoriva

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Andrea Sottoriva

Andrea Sottoriva

Publications by authors named "Andrea Sottoriva"

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Measuring Clonal Evolution in Cancer with Genomics.

Annu Rev Genomics Hum Genet 2019 Aug 5;20:309-329. Epub 2019 May 5.

Evolution and Cancer Laboratory, Barts Cancer Institute, Queen Mary University of London, London EC1M 6BQ, United Kingdom; email:

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http://dx.doi.org/10.1146/annurev-genom-083117-021712DOI Listing
August 2019

Resolving genetic heterogeneity in cancer.

Nat Rev Genet 2019 07;20(7):404-416

Cancer Evolution and Genome Instability Laboratory, Francis Crick Institute, London, UK.

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http://dx.doi.org/10.1038/s41576-019-0114-6DOI Listing
July 2019

Spatially constrained tumour growth affects the patterns of clonal selection and neutral drift in cancer genomic data.

PLoS Comput Biol 2019 Jul 29;15(7):e1007243. Epub 2019 Jul 29.

Evolutionary Genomics and Modelling Lab, Centre for Evolution and Cancer, The Institute of Cancer Research, London, United Kingdom.

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http://dx.doi.org/10.1371/journal.pcbi.1007243DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6687187PMC
July 2019

Reply to 'Revisiting signatures of neutral tumor evolution in the light of complexity of cancer genomic data'.

Nat Genet 2018 12;50(12):1628-1630

Evolutionary Genomics and Modelling Lab, Centre for Evolution and Cancer, the Institute of Cancer Research, London, UK.

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http://dx.doi.org/10.1038/s41588-018-0210-0DOI Listing
December 2018

Reply to 'Currently available bulk sequencing data do not necessarily support a model of neutral tumor evolution'.

Nat Genet 2018 12;50(12):1624-1626

Evolutionary Genomics and Modelling Lab, Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK.

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http://dx.doi.org/10.1038/s41588-018-0235-4DOI Listing
December 2018

Reply to 'Neutral tumor evolution?'

Nat Genet 2018 12;50(12):1633-1637

Evolutionary Genomics and Modelling Lab, Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK.

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http://dx.doi.org/10.1038/s41588-018-0256-zDOI Listing
December 2018

Author Correction: Quantification of subclonal selection in cancer from bulk sequencing data.

Nat Genet 2018 09;50(9):1342

Evolution and Cancer Laboratory, Barts Cancer Institute, Queen Mary University of London, London, UK.

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http://dx.doi.org/10.1038/s41588-018-0169-xDOI Listing
September 2018

Detecting repeated cancer evolution from multi-region tumor sequencing data.

Nat Methods 2018 09 31;15(9):707-714. Epub 2018 Aug 31.

Evolutionary Genomics and Modelling Lab, Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK.

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http://dx.doi.org/10.1038/s41592-018-0108-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6380470PMC
September 2018

Quantification of subclonal selection in cancer from bulk sequencing data.

Nat Genet 2018 06 28;50(6):895-903. Epub 2018 May 28.

Evolution and Cancer Laboratory, Barts Cancer Institute, Queen Mary University of London, London, UK.

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http://dx.doi.org/10.1038/s41588-018-0128-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6475346PMC
June 2018

Variation of mutational burden in healthy human tissues suggests non-random strand segregation and allows measuring somatic mutation rates.

PLoS Comput Biol 2018 06 7;14(6):e1006233. Epub 2018 Jun 7.

Evolutionary Genomics & Modelling Lab, Centre for Evolution and Cancer, The Institute of Cancer Research, London, United Kingdom.

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http://dx.doi.org/10.1371/journal.pcbi.1006233DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6007938PMC
June 2018

Reply: Uncertainties in tumor allele frequencies limit power to infer evolutionary pressures.

Nat Genet 2017 08;49(9):1289-1291

Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK.

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http://dx.doi.org/10.1038/ng.3877DOI Listing
August 2017

Between-region genetic divergence reflects the mode and tempo of tumor evolution.

Nat Genet 2017 Jul 5;49(7):1015-1024. Epub 2017 Jun 5.

Department of Medicine, Stanford University School of Medicine, Stanford, California, USA.

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http://dx.doi.org/10.1038/ng.3891DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5643198PMC
July 2017

Catch my drift? Making sense of genomic intra-tumour heterogeneity.

Biochim Biophys Acta Rev Cancer 2017 Apr 7;1867(2):95-100. Epub 2017 Jan 7.

Evolution and Cancer Laboratory, Barts Cancer Institute, Charterhouse Sq, Queen Mary University of London, EC1M 6BQ, UK. Electronic address:

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http://dx.doi.org/10.1016/j.bbcan.2016.12.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5446319PMC
April 2017

Detecting truly clonal alterations from multi-region profiling of tumours.

Sci Rep 2017 03 27;7:44991. Epub 2017 Mar 27.

Division of Hematology and Department of Internal Medicine, Mayo Clinic, Rochester, MN, USA.

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http://www.nature.com/articles/srep44991
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http://dx.doi.org/10.1038/srep44991DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5366809PMC
March 2017

Measuring cancer evolution from the genome.

J Pathol 2017 Jan 18;241(2):183-191. Epub 2016 Nov 18.

Cancer Evolutionary Genomics and Modelling Laboratory, Centre for Evolution and Cancer, The Institute of Cancer Research, Sutton, UK.

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http://dx.doi.org/10.1002/path.4821DOI Listing
January 2017

EGFRvIII mutations can emerge as late and heterogenous events in glioblastoma development and promote angiogenesis through Src activation.

Neuro Oncol 2016 12 10;18(12):1644-1655. Epub 2016 Jun 10.

Department of Biomedicine, University of Bergen, Norway (E.E., G.V.R., K.M.T., O.K., T.T., K.V., J.A.H., J.V.J., R.J., H.S.S., L.L., T.D., P.Ø.E., R.B., H.M.); KG Jebsen Brain Tumor Research Center, University of Bergen, Norway (E.E., G.V.R., K.M.T., O.K., K.V., J.A.H., J.V.J., T.D., P. Ø.E., S.P.N., R.B., H.M.); Department of Clinical Science, University of Bergen, Norway (S.K.); Department of Oncology, Haukeland University Hospital, Bergen, Norway (S.K.); Norlux Neuro-Oncology Laboratory, Department of Oncology, Luxembourg Institute of Health, Luxembourg (O.K., S.F., S.P.N., R.B.); Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK (A.S.); Department of Clinical Pharmacy, Institute of Pharmacy, Ernst-Moritz-Arndt-University, Greifswald, Germany (S.F., C.A.R.); Department of Neurooncology, University Hospital Heidelberg, Germany (G.S., F.W.); Institute of Scientific Instruments, ASCR, Brno, Czech Republic (R.J.); Edinger-Intsitute, Goethe-University Medical School, Frankfurt am Main, Germany (P.N.H.); Department of Pathology, Haukeland University Hospital, Bergen, Norway (J.A.H., H.M.); Department of Clinical Neurosciences, University of Cambridge, UK (S.G.P., C.W.); Statistics and Computational Biology Laboratory, University of Cambridge, UK (I.S.); Neuro Clinic, Haukeland University Hospital, Bergen, Norway; Department of Experimental Neurology, Charité - Universitätsmedizin Berlin, Germany (P.E.); Department of Systems Medicine, University of Rome «Tor Vergata», Rome, Italy (G.G.); INSERM U1029 - University of Bordeaux, Allée Geoffroy St. Hilaire, Pessac, France (T.D.); Department of Neurosurgery, Haukeland University Hospital, Bergen, Norway (M.L.-J., P. Ø.E.).

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http://dx.doi.org/10.1093/neuonc/now113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5791772PMC
December 2016

Functional versus non-functional intratumor heterogeneity in cancer.

Mol Cell Oncol 2016 Jul 22;3(4):e1162897. Epub 2016 Apr 22.

Centre for Evolution and Cancer, The Institute of Cancer Research , London, UK.

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http://dx.doi.org/10.1080/23723556.2016.1162897DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4972105PMC
July 2016

The Cancer Stem Cell Fraction in Hierarchically Organized Tumors Can Be Estimated Using Mathematical Modeling and Patient-Specific Treatment Trajectories.

Cancer Res 2016 04 1;76(7):1705-13. Epub 2016 Feb 1.

Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, Massachusetts. Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, Massachusetts. Program for Evolutionary Dynamics, Harvard University, Cambridge, Massachusetts.

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http://scholar.harvard.edu/files/paltrock/files/cancer_res-2
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http://cancerres.aacrjournals.org/cgi/doi/10.1158/0008-5472.
Publisher Site
http://dx.doi.org/10.1158/0008-5472.CAN-15-2069DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4900896PMC
April 2016

Identification of neutral tumor evolution across cancer types.

Nat Genet 2016 Mar 18;48(3):238-244. Epub 2016 Jan 18.

Centre for Evolution and Cancer, The Institute of Cancer Research, London, SM2 5NG, UK.

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http://dx.doi.org/10.1038/ng.3489DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4934603PMC
March 2016

Cancer Evolution and the Limits of Predictability in Precision Cancer Medicine.

Trends Cancer 2016 Jan 29;2(1):49-63. Epub 2016 Jan 29.

Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK; Gastrointestinal Cancer Unit, The Royal Marsden Hospital, London, UK. Electronic address:

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http://dx.doi.org/10.1016/j.trecan.2015.11.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4756277PMC
January 2016

Current Challenges in Glioblastoma: Intratumour Heterogeneity, Residual Disease, and Models to Predict Disease Recurrence.

Front Oncol 2015 16;5:251. Epub 2015 Nov 16.

Brain Tumour Research Group, Institute of Clinical Neurosciences, University of Bristol , Bristol , UK.

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http://dx.doi.org/10.3389/fonc.2015.00251DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4644939PMC
December 2015

Many private mutations originate from the first few divisions of a human colorectal adenoma.

J Pathol 2015 Nov 3;237(3):355-62. Epub 2015 Aug 3.

Department of Pathology, Keck School of Medicine of the University of Southern California, Los Angeles, California, USA.

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http://doi.wiley.com/10.1002/path.4581
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http://dx.doi.org/10.1002/path.4581DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4607608PMC
November 2015

The role of sub-ventricular zone in gliomagenesis.

Aging (Albany NY) 2015 Oct;7(10):738-9

University of Cambridge, Clinical Neurosciences, Cambridge, U.K.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4637196PMC
http://dx.doi.org/10.18632/aging.100823DOI Listing
October 2015

Epigenetic profile of human adventitial progenitor cells correlates with therapeutic outcomes in a mouse model of limb ischemia.

Arterioscler Thromb Vasc Biol 2015 Mar 8;35(3):675-88. Epub 2015 Jan 8.

From the Bristol Heart Institute, School of Clinical Sciences, University of Bristol, Bristol, UK (M.G., S.C.S., H.L.S., F.R., J.R., E.A., R.K., G.M., A.O., C.R., C.E., G.A., P.M.); The Institute of Cancer Research, Evolutionary Genomics and Modelling Team, Centre for Evolution and Cancer, Sutton, UK (I.S., A.S.); Imperial College, London, UK (P.C., C.E., G.A.); MultiMedica Research Institute, Milan, Italy (G.S.); Cancer Research UK Cambridge Institute, Cambridge, UK (A.T., S.T.); Centro Cardiologico Monzino, Milan, Italy (F.P., M.P.); and Austrian Institute of Technology, Vienna, Austria (M.H., V.K.).

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http://dx.doi.org/10.1161/ATVBAHA.114.304989DOI Listing
March 2015

A Big Bang model of human colorectal tumor growth.

Nat Genet 2015 Mar 9;47(3):209-16. Epub 2015 Feb 9.

Department of Preventive Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, California, USA.

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http://dx.doi.org/10.1038/ng.3214DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4575589PMC
March 2015

Defining stem cell dynamics in models of intestinal tumor initiation.

Science 2013 Nov;342(6161):995-8

Cancer Research UK, Cambridge Institute, University of Cambridge, Robinson Way, Cambridge CB2 0RE, UK.

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http://dx.doi.org/10.1126/science.1243148DOI Listing
November 2013

The shaping and functional consequences of the microRNA landscape in breast cancer.

Nature 2013 May 5;497(7449):378-82. Epub 2013 May 5.

Cancer Research UK Cambridge Institute and Department of Oncology, University of Cambridge, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK.

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http://dx.doi.org/10.1038/nature12108DOI Listing
May 2013

Intratumor heterogeneity in human glioblastoma reflects cancer evolutionary dynamics.

Proc Natl Acad Sci U S A 2013 Mar 14;110(10):4009-14. Epub 2013 Feb 14.

Department of Oncology, University of Cambridge, Cambridge CB2 2XZ, United Kingdom.

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http://dx.doi.org/10.1073/pnas.1219747110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3593922PMC
March 2013

Modeling evolutionary dynamics of epigenetic mutations in hierarchically organized tumors.

PLoS Comput Biol 2011 May 5;7(5):e1001132. Epub 2011 May 5.

Computational Biology Group, University of Cambridge, CRUK Cambridge Research Institute, Li Ka Shing Centre, Cambridge, United Kingdom.

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http://dx.doi.org/10.1371/journal.pcbi.1001132DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3088646PMC
May 2011

Exploring cancer stem cell niche directed tumor growth.

Cell Cycle 2010 Apr 15;9(8):1472-9. Epub 2010 Apr 15.

University of Cambridge, CRUK Cambridge Research Institute, Cambridge, UK.

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http://dx.doi.org/10.4161/cc.9.8.11198DOI Listing
April 2010