Publications Authored by Andrea Sartore-Bianchi

Negative Hyperselection of Patients With and Wild-Type Metastatic Colorectal Cancer Who Received Panitumumab-Based Maintenance Therapy.

J Clin Oncol 2019 Nov 20;37(33):3099-3110. Epub 2019 Sep 20.

Fondazione Instituto di Ricovero e Cura Carattere Scientifico (IRCCS) Istituto Nazionale dei Tumori, Milan, Italy.

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http://dx.doi.org/10.1200/JCO.19.01254	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6864846	PMC

November 2019

A Comprehensive PDX Gastric Cancer Collection Captures Cancer Cell-Intrinsic Transcriptional MSI Traits.

Authors:

Simona Corso Claudio Isella Sara E Bellomo Maria Apicella Stefania Durando Cristina Migliore Stefano Ughetto Laura D'Errico Silvia Menegon Daniel Moya-Rull Marilisa Cargnelutti Tânia Capelôa Daniela Conticelli Jessica Giordano Tiziana Venesio Antonella Balsamo Caterina Marchiò Maurizio Degiuli Rossella Reddavid Uberto Fumagalli Stefano De Pascale Giovanni Sgroi Emanuele Rausa Gian Luca Baiocchi Sarah Molfino Filippo Pietrantonio Federica Morano Salvatore Siena Andrea Sartore-Bianchi Maria Bencivenga Valentina Mengardo Riccardo Rosati Daniele Marrelli Paolo Morgagni Stefano Rausei Giovanni Pallabazzer Michele De Simone Dario Ribero Silvia Marsoni Antonino Sottile Enzo Medico Paola Cassoni Anna Sapino Eirini Pectasides Aaron R Thorner Anwesha Nag Samantha D Drinan Bruce M Wollison Adam J Bass Silvia Giordano

Cancer Res 2019 Nov 4;79(22):5884-5896. Epub 2019 Oct 4.

Department of Oncology, University of Torino, Candiolo, Italy.

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http://dx.doi.org/10.1158/0008-5472.CAN-19-1166	DOI Listing

November 2019

Adaptive mutability of colorectal cancers in response to targeted therapies.

Science 2019 Nov 7. Epub 2019 Nov 7.

Candiolo Cancer Institute, FPO-IRCCS, Candiolo (TO) 10060, Italy.

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http://dx.doi.org/10.1126/science.aav4474	DOI Listing

November 2019

Capecitabine and temozolomide versus FOLFIRI in mutated, methylated metastatic colorectal cancer.

Clin Cancer Res 2019 Nov 18. Epub 2019 Nov 18.

Medical Oncology and Hematology, Fondazione IRCCS Istituto Nazionale dei Tumori and Università degli Studi Milan of Milan.

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http://dx.doi.org/10.1158/1078-0432.CCR-19-3024	DOI Listing

November 2019

HER2 Positivity Predicts Unresponsiveness to EGFR-Targeted Treatment in Metastatic Colorectal Cancer.

Oncologist 2019 Oct 5;24(10):1395-1402. Epub 2019 Apr 5.

Niguarda Cancer Center, Grande Ospedale Metropolitano Niguarda, Milan, Italy

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http://dx.doi.org/10.1634/theoncologist.2018-0785	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6795149	PMC

October 2019

Patient-Derived Xenografts and Matched Cell Lines Identify Pharmacogenomic Vulnerabilities in Colorectal Cancer.

Clin Cancer Res 2019 Oct 2;25(20):6243-6259. Epub 2019 Aug 2.

Department of Oncology, University of Torino, Candiolo, Torino, Italy.

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http://dx.doi.org/10.1158/1078-0432.CCR-18-3440	DOI Listing

October 2019

A validated prognostic classifier for BRAF-mutated metastatic colorectal cancer: the 'BRAF BeCool' study.

Eur J Cancer 2019 Sep 19;118:121-130. Epub 2019 Jul 19.

S.C.D.U. Medical Oncology, A.O. Ordine Mauriziano Hospital, Department of Oncology, University of Turin, Turin, Italy.

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http://dx.doi.org/10.1016/j.ejca.2019.06.008	DOI Listing

September 2019

The Evolving Biomarker Landscape for Treatment Selection in Metastatic Colorectal Cancer.

Authors:

Julien Taieb Andreas Jung Andrea Sartore-Bianchi Marc Peeters Jenny Seligmann Aziz Zaanan Peter Burdon Clara Montagut Pierre Laurent-Puig

Drugs 2019 Sep;79(13):1375-1394

Sorbonne Paris Cité, Paris Descartes University, Georges Pompidou European Hospital, Paris, France.

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http://dx.doi.org/10.1007/s40265-019-01165-2	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6728290	PMC

September 2019

Liquid biopsy for rectal cancer: A systematic review.

Authors:

Daniela Massihnia Elio Gregory Pizzutilo Alessio Amatu Federica Tosi Silvia Ghezzi Katia Bencardino Pietro Di Masi Elena Righetti Giorgio Patelli Francesco Scaglione Angelo Vanzulli Salvatore Siena Andrea Sartore-Bianchi

Cancer Treat Rev 2019 Sep 31;79:101893. Epub 2019 Aug 31.

Niguarda Cancer Center, Grande Ospedale Metropolitano Niguarda, Milan, Italy; Università degli Studi di Milano, Department of Oncology and Hemato-Oncology, Milan, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.ctrv.2019.101893	DOI Listing

September 2019

The Amount of Evidence Needed to Support ERBB2 as a Biomarker for Resistance to EGFR Inhibitors in Metastatic Colorectal Cancer.

Authors:

Andrea Sartore-Bianchi Silvia Marsoni Salvatore Siena

JAMA Oncol 2019 Aug 15. Epub 2019 Aug 15.

Niguarda Cancer Center, Grande Ospedale Metropolitano Niguarda, Milan, Italy.

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http://dx.doi.org/10.1001/jamaoncol.2019.2982	DOI Listing

August 2019

Maintenance Therapy With Panitumumab Alone vs Panitumumab Plus Fluorouracil-Leucovorin in Patients With RAS Wild-Type Metastatic Colorectal Cancer: A Phase 2 Randomized Clinical Trial.

JAMA Oncol 2019 Jul 3. Epub 2019 Jul 3.

Oncology and Hemato-oncology Department, University of Milan, Milan, Italy.

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https://jamanetwork.com/journals/jamaoncology/fullarticle/27	Publisher Site
http://dx.doi.org/10.1001/jamaoncol.2019.1467	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6613306	PMC

July 2019

High Circulating Methylated DNA Is a Negative Predictive and Prognostic Marker in Metastatic Colorectal Cancer Patients Treated With Regorafenib.

Front Oncol 2019 12;9:622. Epub 2019 Jul 12.

Candiolo Cancer Institute, FPO-IRCCS, Candiolo, Italy.

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http://dx.doi.org/10.3389/fonc.2019.00622	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6640154	PMC

July 2019

Plasticity of Resistance and Sensitivity to Anti-Epidermal Growth Factor Receptor Inhibitors in Metastatic Colorectal Cancer.

Authors:

Andrea Sartore-Bianchi Salvatore Siena

Handb Exp Pharmacol 2018;249:145-159

Niguarda Cancer Center, Grande Ospedale Metropolitano Niguarda, Piazza Ospedale Maggiore, 3, 20162, Milan, Italy.

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http://link.springer.com/10.1007/164_2017_19	Publisher Site
http://dx.doi.org/10.1007/164_2017_19	DOI Listing

June 2019

Combined Low Densities of FoxP3 and CD3 Tumor-Infiltrating Lymphocytes Identify Stage II Colorectal Cancer at High Risk of Progression.

Cancer Immunol Res 2019 May 25;7(5):751-758. Epub 2019 Feb 25.

Department of Internal Medicine, Humanitas University, Pieve Emanuele, Milan, Italy

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http://dx.doi.org/10.1158/2326-6066.CIR-18-0661	DOI Listing

May 2019

Plasma HER2 () Copy Number Predicts Response to HER2-targeted Therapy in Metastatic Colorectal Cancer.

Authors:

Giulia Siravegna Andrea Sartore-Bianchi Rebecca J Nagy Kanwal Raghav Justin I Odegaard Richard B Lanman Livio Trusolino Silvia Marsoni Salvatore Siena Alberto Bardelli

Clin Cancer Res 2019 May 26;25(10):3046-3053. Epub 2019 Feb 26.

Candiolo Cancer Institute, FPO-IRCCS, Candiolo, Torino, Italy.

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http://dx.doi.org/10.1158/1078-0432.CCR-18-3389	DOI Listing

May 2019

Third- or Later-line Therapy for Metastatic Colorectal Cancer: Reviewing Best Practice.

Authors:

Tanios Bekaii-Saab Richard Kim Tae Won Kim Juan Manuel O'Connor John H Strickler David Malka Andrea Sartore-Bianchi Feng Bi Kensei Yamaguchi Takayuki Yoshino Gerald W Prager

Clin Colorectal Cancer 2019 03 16;18(1):e117-e129. Epub 2018 Nov 16.

Department of Medicine I, Comprehensive Cancer Center Vienna, Medical University Vienna, Vienna, Austria. Electronic address:

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http://dx.doi.org/10.1016/j.clcc.2018.11.002	DOI Listing

March 2019

Early-onset colorectal cancer in young individuals.

Authors:

Gianluca Mauri Andrea Sartore-Bianchi Antonio-Giampiero Russo Silvia Marsoni Alberto Bardelli Salvatore Siena

Mol Oncol 2019 02 22;13(2):109-131. Epub 2018 Dec 22.

Niguarda Cancer Center, Grande Ospedale Metropolitano Niguarda, Dipartimento di Oncologia e Emato-Oncologia, Università degli Studi di Milano (La Statale), Milan, Italy.

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http://dx.doi.org/10.1002/1878-0261.12417	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360363	PMC

February 2019

Retreatment with anti-EGFR monoclonal antibodies in metastatic colorectal cancer: Systematic review of different strategies.

Authors:

Gianluca Mauri Elio Gregory Pizzutilo Alessio Amatu Katia Bencardino Laura Palmeri Erica Francesca Bonazzina Federica Tosi Giulia Carlo Stella Giovanni Burrafato Francesco Scaglione Silvia Marsoni Giulia Siravegna Alberto Bardelli Salvatore Siena Andrea Sartore-Bianchi

Cancer Treat Rev 2019 Feb 27;73:41-53. Epub 2018 Dec 27.

Niguarda Cancer Center, Grande Ospedale Metropolitano Niguarda, Milan, Italy; Università degli Studi di Milano, Dipartimento di Oncologia ed Emato-Oncologia, Milano, Italy. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S03057372183021	Publisher Site
http://dx.doi.org/10.1016/j.ctrv.2018.12.006	DOI Listing

February 2019

Discovery of methylated circulating DNA biomarkers for comprehensive non-invasive monitoring of treatment response in metastatic colorectal cancer.

Gut 2018 11 5;67(11):1995-2005. Epub 2017 Oct 5.

Department of Oncology, University of Torino, Torino, Italy.

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http://dx.doi.org/10.1136/gutjnl-2016-313372	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5897187	PMC

November 2018

TRKA expression and gene copy number across solid tumours.

J Clin Pathol 2018 Oct 25;71(10):926-931. Epub 2018 May 25.

Niguarda Cancer Center, Grande Ospedale Metropolitano Niguarda, Milan, Italy.

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http://dx.doi.org/10.1136/jclinpath-2018-205124	DOI Listing

October 2018

Radiologic and Genomic Evolution of Individual Metastases during HER2 Blockade in Colorectal Cancer.

Cancer Cell 2018 07;34(1):148-162.e7

Candiolo Cancer Institute-FPO, IRCCS, Candiolo, TO, Italy; Department of Oncology, University of Torino, Candiolo, TO 10060, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2018.06.004	DOI Listing

July 2018

Reliance upon ancestral mutations is maintained in colorectal cancers that heterogeneously evolve during targeted therapies.

Authors:

Mariangela Russo Simona Lamba Annalisa Lorenzato Alberto Sogari Giorgio Corti Giuseppe Rospo Benedetta Mussolin Monica Montone Luca Lazzari Sabrina Arena Daniele Oddo Michael Linnebacher Andrea Sartore-Bianchi Filippo Pietrantonio Salvatore Siena Federica Di Nicolantonio Alberto Bardelli

Nat Commun 2018 06 12;9(1):2287. Epub 2018 Jun 12.

Candiolo Cancer Institute-FPO, IRCCS, 10060, Candiolo, Turin, Italy.

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http://dx.doi.org/10.1038/s41467-018-04506-z	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5997733	PMC

June 2018

Parallel Evaluation of Circulating Tumor DNA and Circulating Tumor Cells in Metastatic Colorectal Cancer.

Authors:

Giovanni Germano Gianluca Mauri Giulia Siravegna Caroline Dive Jackie Pierce Federica Di Nicolantonio Maurizio D'Incalci Alberto Bardelli Salvatore Siena Andrea Sartore-Bianchi

Clin Colorectal Cancer 2018 03 1;17(1):80-83. Epub 2017 Nov 1.

Niguarda Cancer Center, Grande Ospedale Metropolitano Niguarda, Milan, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.clcc.2017.10.017	DOI Listing

March 2018

Human Epidermal Growth Factor Receptor 2 as a Molecular Biomarker for Metastatic Colorectal Cancer.

Authors:

Andrea Sartore-Bianchi Silvia Marsoni Salvatore Siena

JAMA Oncol 2018 Jan;4(1):19-20

Niguarda Cancer Center, Grande Ospedale Metropolitano Niguarda, Milan, Italy.

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http://dx.doi.org/10.1001/jamaoncol.2017.3323	DOI Listing

January 2018

Sequential HER2 blockade as effective therapy in chemorefractory, HER2 gene-amplified, RAS wild-type, metastatic colorectal cancer: learning from a clinical case.

Authors:

Erika Martinelli Teresa Troiani Vincenzo Sforza Giulia Martini Claudia Cardone Pietro Paolo Vitiello Davide Ciardiello Anna Maria Rachiglio Nicola Normanno Andrea Sartore-Bianchi Silvia Marsoni Alberto Bardelli Salvatore Siena Fortunato Ciardiello

ESMO Open 2018 10;3(1):e000299. Epub 2018 Jan 10.

Dipartimento di Internistica Clinica e Sperimentale 'F Magrassi', Università degli Studi della Campania L Vanvitelli, Napoli, Italy.

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http://esmoopen.bmj.com/lookup/doi/10.1136/esmoopen-2017-000	Publisher Site
http://dx.doi.org/10.1136/esmoopen-2017-000299	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5786925	PMC

January 2018

Inactivation of DNA repair triggers neoantigen generation and impairs tumour growth.

Nature 2017 12 29;552(7683):116-120. Epub 2017 Nov 29.

Candiolo Cancer Institute - FPO, IRCCS, Candiolo 10060, Turin, Italy.

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http://dx.doi.org/10.1038/nature24673	DOI Listing

December 2017

ALK, ROS1, and NTRK Rearrangements in Metastatic Colorectal Cancer.

J Natl Cancer Inst 2017 12;109(12)

Azienda Ospedaliero, Universitaria Pisana, Pisa, Italy.

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http://dx.doi.org/10.1093/jnci/djx089	DOI Listing

December 2017

Effect of KRAS and BRAF Mutations on Survival of Metastatic Colorectal Cancer After Liver Resection: A Systematic Review and Meta-Analysis.

Authors:

Federica Tosi Elena Magni Alessio Amatu Gianluca Mauri Katia Bencardino Mauro Truini Silvio Veronese Luciano De Carlis Giovanni Ferrari Michele Nichelatti Andrea Sartore-Bianchi Salvatore Siena

Clin Colorectal Cancer 2017 09 25;16(3):e153-e163. Epub 2017 Jan 25.

Niguarda Cancer Center, Grande Ospedale Metropolitano Niguarda, Milano, Italy; Dipartimento di Oncologia e Emato-Oncologia, Università degli Studi di Milano, Milano, Italy.

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http://dx.doi.org/10.1016/j.clcc.2017.01.004	DOI Listing

September 2017

Pooled Analysis of Clinical Outcome of Patients with Chemorefractory Metastatic Colorectal Cancer Treated within Phase I/II Clinical Studies Based on Individual Biomarkers of Susceptibility: A Single-Institution Experience.

Target Oncol 2017 08;12(4):525-533

Niguarda Cancer Center, Grande Ospedale Metropolitano Niguarda, Piazza Ospedale Maggiore, 3, 20162, Milan, Italy.

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http://dx.doi.org/10.1007/s11523-017-0505-6	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5524857	PMC

August 2017

Mutation-Enrichment Next-Generation Sequencing for Quantitative Detection of Mutations in Urine Cell-Free DNA from Patients with Advanced Cancers.

Clin Cancer Res 2017 Jul 17;23(14):3657-3666. Epub 2017 Jan 17.

Department of Investigational Cancer Therapeutics (Phase I Clinical Trials Program), The University of Texas MD Anderson Cancer Center, Houston, Texas.

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http://clincancerres.aacrjournals.org/lookup/doi/10.1158/107	Publisher Site
http://dx.doi.org/10.1158/1078-0432.CCR-16-2592	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5511562	PMC

July 2017

Molecular Markers Beyond Microsatellite Instability for Assessing Prognosis in Early-Stage Colorectal Cancer: What Happens at Relapse?

Authors:

Andrea Sartore-Bianchi

JAMA Oncol 2017 04;3(4):481-482

Department of Hematology and Oncology, Niguarda Cancer Center, Grande Ospedale Metropolitano Niguarda, Milano, Italy.

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http://dx.doi.org/10.1001/jamaoncol.2016.5463	DOI Listing

April 2017

Safety and Antitumor Activity of the Multitargeted Pan-TRK, ROS1, and ALK Inhibitor Entrectinib: Combined Results from Two Phase I Trials (ALKA-372-001 and STARTRK-1).

Cancer Discov 2017 04 9;7(4):400-409. Epub 2017 Feb 9.

Dipartimento di Oncologia e Emato-Oncologia, Università degli Studi di Milano, Milan, Italy.

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http://dx.doi.org/10.1158/2159-8290.CD-16-1237	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5380583	PMC

April 2017

Radiological imaging markers predicting clinical outcome in patients with metastatic colorectal carcinoma treated with regorafenib: post hoc analysis of the CORRECT phase III trial (RadioCORRECT study).

ESMO Open 2016 13;1(6):e000111. Epub 2017 Feb 13.

Niguarda Cancer Center, Grande Ospedale Metropolitano Niguarda, Milan, Italy.

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http://dx.doi.org/10.1136/esmoopen-2016-000111	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5548980	PMC

February 2017

Digital PCR assessment of MGMT promoter methylation coupled with reduced protein expression optimises prediction of response to alkylating agents in metastatic colorectal cancer patients.

Authors:

Andrea Sartore-Bianchi Filippo Pietrantonio Alessio Amatu Massimo Milione Andrea Cassingena Silvia Ghezzi Marta Caporale Rosa Berenato Chiara Falcomatà Alessio Pellegrinelli Alberto Bardelli Michele Nichelatti Federica Tosi Filippo De Braud Federica Di Nicolantonio Ludovic Barault Salvatore Siena

Eur J Cancer 2017 01 18;71:43-50. Epub 2016 Dec 18.

Niguarda Cancer Center, Grande Ospedale Metropolitano Niguarda, Milan, Italy; Università degli Studi di Milano, Milan, Italy.

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http://dx.doi.org/10.1016/j.ejca.2016.10.032	DOI Listing

January 2017

Overcoming dynamic molecular heterogeneity in metastatic colorectal cancer: Multikinase inhibition with regorafenib and the case of rechallenge with anti-EGFR.

Authors:

Andrea Sartore-Bianchi Salvatore Siena Giuseppe Tonini Alberto Bardelli Daniele Santini

Cancer Treat Rev 2016 Dec 29;51:54-62. Epub 2016 Oct 29.

Department of Medical Oncology, Campus Bio-Medico University of Rome, 00128 Rome, Italy. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S03057372163010	Publisher Site
http://dx.doi.org/10.1016/j.ctrv.2016.10.006	DOI Listing

December 2016

Acquired RAS or EGFR mutations and duration of response to EGFR blockade in colorectal cancer.

Nat Commun 2016 12 8;7:13665. Epub 2016 Dec 8.

Candiolo Cancer Institute-FPO, IRCCS, 10060 Candiolo, Torino, Italy.

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http://dx.doi.org/10.1038/ncomms13665	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5155160	PMC

December 2016

Oxaliplatin Immune-Induced Syndrome Occurs With Cumulative Administration and Rechallenge: Single Institution Series and Systematic Review Study.

Authors:

Katia Bencardino Gianluca Mauri Alessio Amatu Federica Tosi Erica Bonazzina Laura Palmeri Marialuisa Querques Federica Ravera Alberto Menegotto Elisa Boiani Andrea Sartore-Bianchi Salvatore Siena

Clin Colorectal Cancer 2016 09 19;15(3):213-21. Epub 2016 Feb 19.

Niguarda Cancer Center, Grande Ospedale Metropolitano Niguarda, Milan, Italy; Dipartimento di Oncologia e Emato-Oncologia, Università degli Studi di Milano, Milan, Italy.

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http://dx.doi.org/10.1016/j.clcc.2016.02.001	DOI Listing

September 2016

Molecular Landscape of Acquired Resistance to Targeted Therapy Combinations in BRAF-Mutant Colorectal Cancer.

Cancer Res 2016 08 16;76(15):4504-15. Epub 2016 Jun 16.

Department of Oncology, University of Torino, Candiolo, Torino, Italy. Candiolo Cancer Institute-FPO, IRCCS, Candiolo, Torino, Italy.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4970882	PMC
http://dx.doi.org/10.1158/0008-5472.CAN-16-0396	DOI Listing

August 2016

Clonal evolution and - coamplification during secondary resistance to EGFR-targeted therapy in metastatic colorectal cancer.

Authors:

Andrea Sartore-Bianchi Emanuele Valtorta Alessio Amatu Silvio Veronese Calogero Lauricella Erica Bonazzina Giulia Siravegna Mauro Truini Alberto Bardelli Salvatore Siena

ESMO Open 2016 4;1(4):e000079. Epub 2016 Aug 4.

Niguarda Cancer Center, Grande Ospedale Metropolitano Niguarda, Milano, Italy; Dipartimento di Oncologia e Emato-Oncologia, Università degli Studi di Milano, Milano, Italy.

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http://esmoopen.bmj.com/lookup/doi/10.1136/esmoopen-2016-000	Publisher Site
http://dx.doi.org/10.1136/esmoopen-2016-000079	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5070243	PMC

August 2016

Dual-targeted therapy with trastuzumab and lapatinib in treatment-refractory, KRAS codon 12/13 wild-type, HER2-positive metastatic colorectal cancer (HERACLES): a proof-of-concept, multicentre, open-label, phase 2 trial.

Lancet Oncol 2016 Jun 20;17(6):738-746. Epub 2016 Apr 20.

Niguarda Cancer Center, Grande Ospedale Metropolitano Niguarda, Milano, Italy; Dipartimento di Oncologia e Emato-Oncologia Università degli Studi di Milano, Milano, Italy.

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http://dx.doi.org/10.1016/S1470-2045(16)00150-9	DOI Listing

June 2016

Linitis Plastica of the Rectum As a Clinical Presentation of Metastatic Lobular Carcinoma of the Breast.

Authors:

Filippo Venturini Valentina Gambi Stefano Di Lernia Angelo Vanzulli Manuela Bramerio Katia Bencardino Alessio Amatu Tiziana Cipani Edoardo Forti Emiliana Tarenzi Andrea Sartore-Bianchi Raffaele Pugliese Salvatore Siena

J Clin Oncol 2016 Mar 30;34(7):e54-6. Epub 2014 Jun 30.

Ospedale Niguarda Ca' Granda, Milan, Italy

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http://dx.doi.org/10.1200/JCO.2013.50.6733	DOI Listing

March 2016

gene fusions as novel targets of cancer therapy across multiple tumour types.

Authors:

Alessio Amatu Andrea Sartore-Bianchi Salvatore Siena

ESMO Open 2016 18;1(2):e000023. Epub 2016 Mar 18.

Niguarda Cancer Center, Grande Ospedale Metropolitano Niguarda, Milan, Italy; Dipartimento di Oncologia e Emato-Oncologia, Università degli Studi di Milano, Milan, Italy.

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http://esmoopen.bmj.com/lookup/doi/10.1136/esmoopen-2015-000	Publisher Site
http://dx.doi.org/10.1136/esmoopen-2015-000023	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5070277	PMC

March 2016

Effects of Cancer Therapy Targeting Vascular Endothelial Growth Factor Receptor on Central Blood Pressure and Cardiovascular System.

Authors:

Antonella Moreo Paola Vallerio Riccardo Ricotta Miriam Stucchi Mattia Pozzi Francesco Musca Paolo Meani Alessandro Maloberti Rita Facchetti Sara Di Bella Maria Olga Giganti Andrea Sartore-Bianchi Salvatore Siena Giuseppe Mancia Cristina Giannattasio

Am J Hypertens 2016 Feb 1;29(2):158-62. Epub 2015 Jun 1.

Cardiology IV, "A.De Gasperis" Department, Ospedale Niguarda Ca' Granda, Milan, Italy; Health Science Department, Milano-Bicocca University, Milan, Italy;

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http://dx.doi.org/10.1093/ajh/hpv077	DOI Listing

February 2016

Tumor Heterogeneity and Lesion-Specific Response to Targeted Therapy in Colorectal Cancer.

Cancer Discov 2016 Feb 7;6(2):147-153. Epub 2015 Dec 7.

Massachusetts General Hospital Cancer Center, Boston, MA, USA.

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http://dx.doi.org/10.1158/2159-8290.CD-15-1283	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4744519	PMC

February 2016

Acquired Resistance to the TRK Inhibitor Entrectinib in Colorectal Cancer.

Cancer Discov 2016 Jan 6;6(1):36-44. Epub 2015 Nov 6.

Department of Oncology, University of Torino, Torino, Italy. Candiolo Cancer Institute, FPO, IRCCS, Torino, Italy.

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http://ignyta.com/wp-content/uploads/2016/01/Response-and-re	Web Search
http://cancerdiscovery.aacrjournals.org/content/early/2015/1	Web Search
http://cancerdiscovery.aacrjournals.org/cgi/doi/10.1158/2159	Publisher Site
http://dx.doi.org/10.1158/2159-8290.CD-15-0940	DOI Listing

January 2016

Sensitivity to Entrectinib Associated With a Novel LMNA-NTRK1 Gene Fusion in Metastatic Colorectal Cancer.

J Natl Cancer Inst 2016 Jan 12;108(1). Epub 2015 Nov 12.

Niguarda Cancer Center, Ospedale Niguarda Ca' Granda, Milan, Italy (ASB, AA, EV, LP, EB, GM, SV, AV, SS); Nerviano Medical Sciences S.r.l Nerviano, Milan, Italy (EA, RB, AS, LR, PB, AL, RA, AG, AI); Candiolo Cancer Institute - FPO, IRCCS, Candiolo, Torino, Italy (SM, AB); University of Torino, Department of Oncology, Candiolo, Torino, Italy (AB); FIRC Institute of Molecular Oncology (IFOM), Milano, Italy (SM); Ignyta, Inc., San Diego, CA (DL, ZH, JL); Clioss S.r.l. Nerviano, Milan, Italy (MM, CD); Università degli Studi di Milano, Milan, Italy (SS).

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http://dx.doi.org/10.1093/jnci/djv306	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4712682	PMC

January 2016

Novel CAD-ALK gene rearrangement is drugable by entrectinib in colorectal cancer.

Br J Cancer 2015 Dec 3;113(12):1730-4. Epub 2015 Dec 3.

Niguarda Cancer Center, Ospedale Niguarda Ca' Granda, 20162 Milan, Italy.

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http://ignyta.com/wp-content/uploads/2016/01/Novel-CAD-ALK-g	Web Search
http://www.nature.com/doifinder/10.1038/bjc.2015.401	Publisher Site
http://dx.doi.org/10.1038/bjc.2015.401	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4701996	PMC

December 2015

Assessment of a HER2 scoring system for colorectal cancer: results from a validation study.

Mod Pathol 2015 Nov 9;28(11):1481-91. Epub 2015 Oct 9.

Niguarda Cancer Center, Ospedale Niguarda Ca' Granda, Milano, Italy.

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http://dx.doi.org/10.1038/modpathol.2015.98	DOI Listing

November 2015

Prognostic significance of K-Ras mutation rate in metastatic colorectal cancer patients.

Oncotarget 2015 Oct;6(31):31604-12

Department of Medical Oncology, Azienda Ospedaliero-Universitaria, Udine, Italy.

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http://dx.doi.org/10.18632/oncotarget.5231	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4741627	PMC

October 2015

The genomic landscape of response to EGFR blockade in colorectal cancer.

Nature 2015 Oct 30;526(7572):263-7. Epub 2015 Sep 30.

Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA.

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http://dx.doi.org/10.1038/nature14969	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4878148	PMC

October 2015

Germ cell tumors overexpress the candidate therapeutic target cyclin B1 independently of p53 function.

Authors:

Ugo De Giorgi Juping Yuan Mauro Moroni Silvio Veronese Andrea Sartore-Bianchi Massimo Broggini Giovanni Rosti Klaus Strebhardt Pier Adelchi Ruffini

Int J Biol Markers 2015 Jul 22;30(3):e275-81. Epub 2015 Jul 22.

Department of Medical Oncology, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, Meldola (Forlì-Cesena) - Italy.

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http://dx.doi.org/10.5301/jbm.5000149	DOI Listing

July 2015

Clonal evolution and resistance to EGFR blockade in the blood of colorectal cancer patients.

Nat Med 2015 Jul 1;21(7):795-801. Epub 2015 Jun 1.

1] University of Torino, Department of Oncology, Torino, Italy. [2] Candiolo Cancer Institute - Fondazione Piemontese per l'Oncologia (FPO), Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Candiolo, Torino, Italy.

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http://dx.doi.org/10.1038/nm.3870	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4868598	PMC

July 2015

Clonal evolution and resistance to EGFR blockade in the blood of colorectal cancer patients.

Nat Med 2015 Jul;21(7):827

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http://dx.doi.org/10.1038/nm0715-827b	DOI Listing

July 2015

The molecular landscape of colorectal cancer cell lines unveils clinically actionable kinase targets.

Authors:

Enzo Medico Mariangela Russo Gabriele Picco Carlotta Cancelliere Emanuele Valtorta Giorgio Corti Michela Buscarino Claudio Isella Simona Lamba Barbara Martinoglio Silvio Veronese Salvatore Siena Andrea Sartore-Bianchi Marco Beccuti Marcella Mottolese Michael Linnebacher Francesca Cordero Federica Di Nicolantonio Alberto Bardelli

Nat Commun 2015 Apr 30;6:7002. Epub 2015 Apr 30.

1] Department of Oncology, University of Torino, SP 142, Km 3.95, 10060, Candiolo, Torino, Italy [2] Candiolo Cancer Institute-FPO, IRCCS, 10060, Candiolo (TO), Italy.

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http://dx.doi.org/10.1038/ncomms8002	DOI Listing

April 2015

The TPM3-NTRK1 rearrangement is a recurring event in colorectal carcinoma and is associated with tumor sensitivity to TRKA kinase inhibition.

Mol Oncol 2014 Dec 12;8(8):1495-507. Epub 2014 Jun 12.

Nerviano Medical Sciences S.r.l., Nerviano (Milan), Italy.

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http://doi.wiley.com/10.1016/j.molonc.2014.06.001	Publisher Site
http://dx.doi.org/10.1016/j.molonc.2014.06.001	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5528583	PMC

December 2014

Resistance to anti-EGFR therapy in colorectal cancer: from heterogeneity to convergent evolution.

Authors:

Sandra Misale Federica Di Nicolantonio Andrea Sartore-Bianchi Salvatore Siena Alberto Bardelli

Cancer Discov 2014 Nov 7;4(11):1269-80. Epub 2014 Oct 7.

Department of Oncology, University of Torino, Candiolo, Torino, Italy. Candiolo Cancer Institute - FPO, IRCCS, Candiolo, Torino, Italy. FIRC Institute of Molecular Oncology (IFOM), Milano, Italy.

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http://dx.doi.org/10.1158/2159-8290.CD-14-0462	DOI Listing

November 2014

Acquired resistance to EGFR-targeted therapies in colorectal cancer.

Authors:

Beth O Van Emburgh Andrea Sartore-Bianchi Federica Di Nicolantonio Salvatore Siena Alberto Bardelli

Mol Oncol 2014 Sep 14;8(6):1084-94. Epub 2014 May 14.

Candiolo Cancer Institute - FPO, IRCCS, Str prov 142 Km 3.95, 10060 Candiolo, Torino, Italy; University of Torino, Department of Oncology, Strada Provinciale, 142 km 3.95, 10060 Candiolo, Torino, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.molonc.2014.05.003	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5528615	PMC

September 2014

Phase II open-label study to assess efficacy and safety of lenalidomide in combination with cetuximab in KRAS-mutant metastatic colorectal cancer.

Authors:

Salvatore Siena Eric Van Cutsem Mingyu Li Ulf Jungnelius Alfredo Romano Robert Beck Katia Bencardino Maria Elena Elez Hans Prenen Mireia Sanchis Andrea Sartore-Bianchi Sabine Tejpar Anita Gandhi Tao Shi Josep Tabernero

PLoS One 2013 11;8(11):e62264. Epub 2013 Nov 11.

Ospedale Niguarda Ca' Granda, Milan, Italy.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0062264	PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3823943	PMC

July 2014

Translational challenges from the 2014 Gastrointestinal Cancers Symposium: toward a true tailored therapy through effective research.

Authors:

Giuseppe Aprile Francesco Giuliani Stefano Cordio Andrea Sartore-Bianchi Katia Bencardino Elena Ongaro Concetta Martines Riccardo Giampieri Roberto Bordonaro Salvatore Siena Stefano Cascinu Mario Scartozzi

Future Oncol 2014 May;10(7):1125-8

Medical Oncology, University & General Hospital, Udine, Italy.

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http://dx.doi.org/10.2217/fon.14.54	DOI Listing

May 2014

Regorafenib in metastatic colorectal cancer.

Authors:

Andrea Sartore-Bianchi Annalisa Zeppellini Alessio Amatu Riccardo Ricotta Katia Bencardino Salvatore Siena

Expert Rev Anticancer Ther 2014 Mar;14(3):255-65

Department of Hematology and Oncology, Niguarda Cancer Center, Ospedale Niguarda Ca' Granda, Milan, Italy.

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http://dx.doi.org/10.1586/14737140.2014.894887	DOI Listing

March 2014

Detection of circulating tumor DNA in early- and late-stage human malignancies.

Authors:

Chetan Bettegowda Mark Sausen Rebecca J Leary Isaac Kinde Yuxuan Wang Nishant Agrawal Bjarne R Bartlett Hao Wang Brandon Luber Rhoda M Alani Emmanuel S Antonarakis Nilofer S Azad Alberto Bardelli Henry Brem John L Cameron Clarence C Lee Leslie A Fecher Gary L Gallia Peter Gibbs Dung Le Robert L Giuntoli Michael Goggins Michael D Hogarty Matthias Holdhoff Seung-Mo Hong Yuchen Jiao Hartmut H Juhl Jenny J Kim Giulia Siravegna Daniel A Laheru Calogero Lauricella Michael Lim Evan J Lipson Suely Kazue Nagahashi Marie George J Netto Kelly S Oliner Alessandro Olivi Louise Olsson Gregory J Riggins Andrea Sartore-Bianchi Kerstin Schmidt le-Ming Shih Sueli Mieko Oba-Shinjo Salvatore Siena Dan Theodorescu Jeanne Tie Timothy T Harkins Silvio Veronese Tian-Li Wang Jon D Weingart Christopher L Wolfgang Laura D Wood Dongmei Xing Ralph H Hruban Jian Wu Peter J Allen C Max Schmidt Michael A Choti Victor E Velculescu Kenneth W Kinzler Bert Vogelstein Nickolas Papadopoulos Luis A Diaz

Sci Transl Med 2014 Feb;6(224):224ra24

Ludwig Center for Cancer Genetics and Therapeutics, Howard Hughes Medical Institute and the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21231, USA.

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http://dx.doi.org/10.1126/scitranslmed.3007094	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4017867	PMC

February 2014

Blockade of EGFR and MEK intercepts heterogeneous mechanisms of acquired resistance to anti-EGFR therapies in colorectal cancer.

Authors:

Sandra Misale Sabrina Arena Simona Lamba Giulia Siravegna Alice Lallo Sebastijan Hobor Mariangela Russo Michela Buscarino Luca Lazzari Andrea Sartore-Bianchi Katia Bencardino Alessio Amatu Calogero Lauricella Emanuele Valtorta Salvatore Siena Federica Di Nicolantonio Alberto Bardelli

Sci Transl Med 2014 Feb;6(224):224ra26

Department of Oncology, University of Torino, 10060 Candiolo, Torino, Italy.

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http://dx.doi.org/10.1126/scitranslmed.3007947	DOI Listing

February 2014

Epigenetic inactivation of the BRCA1 interactor SRBC and resistance to oxaliplatin in colorectal cancer.

Authors:

Catia Moutinho Anna Martinez-Cardús Cristina Santos Valentin Navarro-Pérez Eva Martínez-Balibrea Eva Musulen F Javier Carmona Andrea Sartore-Bianchi Andrea Cassingena Salvatore Siena Elena Elez Josep Tabernero Ramon Salazar Albert Abad Manel Esteller

J Natl Cancer Inst 2014 Jan 22;106(1):djt322. Epub 2013 Nov 22.

Affiliations of authors: Cancer Epigenetics and Biology Program, Bellvitge Biomedical Research Institute, Barcelona, Spain (CM, AM-C, FJC, ME); Medical Oncology Service, Catalan Institute of Oncology, Health Sciences Research Institute of the Germans Trias i Pujol Foundation, Barcelona, Spain (AM-C, EM-B, AA); Department of Medical Oncology (CS, RS) and Clinical Informatics Unit (VN-P), Catalan Institute of Oncology, Bellvitge Biomedical Research Institute, L'Hospitalet de Llobregat, Barcelona, Spain; Department of Pathology, Germans Trias i Pujol Foundation, Barcelona, Spain (EM); Department of Hematology and Oncology, Ospedale Niguarda Ca' Granda, Milan, Italy (AS-B, AC, SS); Medical Oncology Department, Vall d'Hebron University Hospital, Barcelona, Spain (EE, JT); Department of Physiological Sciences II, School of Medicine, University of Barcelona, Barcelona, Barcelona, Spain (ME); Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain (ME).

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http://dx.doi.org/10.1093/jnci/djt322	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3906989	PMC

January 2014

Panitumumab in combination with infusional oxaliplatin and oral capecitabine for conversion therapy in patients with colon cancer and advanced liver metastases. The MetaPan study.

Authors:

Francesco Leone Salvatore Artale Donatella Marino Celeste Cagnazzo Stefano Cascinu Carmine Pinto Giuseppe Fornarini Marco Tampellini Francesca Di Fabio Andrea Sartore-Bianchi Luciano De Carlis Raffaele Pugliese Lorenzo Capussotti Luisa Gioeni Salvatore Siena Massimo Aglietta

Cancer 2013 Oct 18;119(19):3429-35. Epub 2013 Jul 18.

Department of Medical Oncology, Piemonte Oncology Foundation, IRCC-Candiolo, Candiolo, Italy.

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http://dx.doi.org/10.1002/cncr.28223	DOI Listing

October 2013

KRAS gene amplification in colorectal cancer and impact on response to EGFR-targeted therapy.

Int J Cancer 2013 Sep 16;133(5):1259-65. Epub 2013 Mar 16.

Division of Pathology, Ospedale Niguarda Ca' Granda, Piazza Ospedale Maggiore 3, Milano, Italy.

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http://dx.doi.org/10.1002/ijc.28106	DOI Listing

September 2013

Aspirin for colorectal cancer with PIK3CA mutations: the rising of the oldest targeted therapy?

Authors:

Alessio Amatu Katia Bencardino Andrea Sartore-Bianchi Salvatore Siena

Ann Transl Med 2013 Jul;1(2):12

Department of Oncology, Ospedale Niguarda Ca' Granda, Milano, Italy.

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http://dx.doi.org/10.3978/j.issn.2305-5839.2013.01.03	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4200636	PMC

July 2013

Amplification of the MET receptor drives resistance to anti-EGFR therapies in colorectal cancer.

Cancer Discov 2013 Jun 2;3(6):658-73. Epub 2013 Jun 2.

Department of Oncology, University of Torino, Torino, Italy.

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http://dx.doi.org/10.1158/2159-8290.CD-12-0558	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4078408	PMC

June 2013

Regorafenib for metastatic colorectal cancer.

Authors:

Riccardo Ricotta Andrea Sartore-Bianchi Antonella Verrioli Angelo Vanzulli Salvatore Siena

Lancet 2013 May;381(9877):1537

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http://dx.doi.org/10.1016/S0140-6736(13)60976-9	DOI Listing

May 2013

Promoter CpG island hypermethylation of the DNA repair enzyme MGMT predicts clinical response to dacarbazine in a phase II study for metastatic colorectal cancer.

Authors:

Alessio Amatu Andrea Sartore-Bianchi Catia Moutinho Alessandro Belotti Katia Bencardino Giuseppe Chirico Andrea Cassingena Francesca Rusconi Anna Esposito Michele Nichelatti Manel Esteller Salvatore Siena

Clin Cancer Res 2013 Apr 19;19(8):2265-72. Epub 2013 Feb 19.

Department of Hematology and Oncology, Ospedale Niguarda Ca' Granda, Milan, Italy.

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http://dx.doi.org/10.1158/1078-0432.CCR-12-3518	DOI Listing

April 2013

Magnetic resonance imaging as an early indicator of clinical outcome in patients with metastatic colorectal carcinoma treated with cetuximab or panitumumab.

Authors:

Riccardo Ricotta Angelo Vanzulli Mauro Moroni Barbara Colnago Matteo Oriani Michele Nichelatti Carolina Sarnataro Filippo Venturini Sara Di Bella Martina Maiolani Maria Olga Giganti Andrea Sartore-Bianchi Salvatore Siena

Clin Colorectal Cancer 2013 Mar 4;12(1):45-53. Epub 2012 Oct 4.

The Falck Division of Oncology, Ospedale Niguarda Ca' Granda, Milan, Italy.

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http://dx.doi.org/10.1016/j.clcc.2012.07.001	DOI Listing

March 2013

New frontiers in therapeutic resistance in cancer.

Authors:

Andrea Sartore-Bianchi Mauro Delorenzi Thérèse Gagnon-Kugler Caroline Rousseau Gerald Batist

Expert Rev Anticancer Ther 2012 Jul;12(7):877-9

Falck Division of Medical Oncology, Department of Oncology, Ospedale Niguarda Ca' Granda, Piazza Ospedale Maggiore, 3 20162 Milano, Italy.

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http://dx.doi.org/10.1586/era.12.71	DOI Listing

July 2012

Emergence of KRAS mutations and acquired resistance to anti-EGFR therapy in colorectal cancer.

Nature 2012 Jun;486(7404):532-6

Laboratory of Molecular Genetics, Institute for Cancer Research and Treatment, 10060 Candiolo (Torino), Italy.

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http://dx.doi.org/10.1038/nature11156	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3927413	PMC

June 2012

Standardisation of EGFR FISH in colorectal cancer: results of an international interlaboratory reproducibility ring study.

Authors:

Andrea Sartore-Bianchi Steffen Fieuws Silvio Veronese Mauro Moroni Nicola Personeni Milo Frattini Valter Torri Federico Cappuzzo Sara Vander Borght Vittoria Martin Margaret Skokan Armando Santoro Marcello Gambacorta Sabine Tejpar Marileila Varella-Garcia Salvatore Siena

J Clin Pathol 2012 Mar 30;65(3):218-23. Epub 2011 Nov 30.

The FalcK Division Of Medical Oncology, Ospedale Niguarda Ca' Granda, Milan, Italy.

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http://dx.doi.org/10.1136/jclinpath-2011-200353	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4612522	PMC

March 2012

A molecularly annotated platform of patient-derived xenografts ("xenopatients") identifies HER2 as an effective therapeutic target in cetuximab-resistant colorectal cancer.

Cancer Discov 2011 Nov 2;1(6):508-23. Epub 2011 Sep 2.

Laboratory of Molecular Pharmacology, Division of Surgical Oncology, Unit of Pathology, Institute for Cancer Research and Treatment, Torino, Italy.

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http://dx.doi.org/10.1158/2159-8290.CD-11-0109	DOI Listing

November 2011

Association of KRAS p.G13D mutation with outcome in patients with chemotherapy-refractory metastatic colorectal cancer treated with cetuximab.

Authors:

Wendy De Roock Derek J Jonker Federica Di Nicolantonio Andrea Sartore-Bianchi Dongsheng Tu Salvatore Siena Simona Lamba Sabrina Arena Milo Frattini Hubert Piessevaux Eric Van Cutsem Chris J O'Callaghan Shirin Khambata-Ford John R Zalcberg John Simes Christos S Karapetis Alberto Bardelli Sabine Tejpar

JAMA 2010 Oct;304(16):1812-20

Center for Human Genetics, University of Leuven, Leuven, Belgium.

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http://publicationslist.org/data/andrea.sartore-bianchi/ref-	Web Search
http://jama.jamanetwork.com/article.aspx?doi=10.1001/jama.20	Publisher Site
http://dx.doi.org/10.1001/jama.2010.1535	DOI Listing

October 2010

Effects of KRAS, BRAF, NRAS, and PIK3CA mutations on the efficacy of cetuximab plus chemotherapy in chemotherapy-refractory metastatic colorectal cancer: a retrospective consortium analysis.

Lancet Oncol 2010 Aug 8;11(8):753-62. Epub 2010 Jul 8.

Centre for Human Genetics, KU Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1016/S1470-2045(10)70130-3	DOI Listing

August 2010

Integrated molecular dissection of the epidermal growth factor receptor (EGFR) [corrected] oncogenic pathway to predict response to EGFR-targeted monoclonal antibodies in metastatic colorectal cancer.

Authors:

Andrea Sartore-Bianchi Katia Bencardino Federica Di Nicolantonio Federico Pozzi Chiara Funaioli Valentina Gambi Sabrina Arena Miriam Martini Simona Lamba Andrea Cassingena Roberta Schiavo Alberto Bardelli Salvatore Siena

Target Oncol 2010 Mar 11;5(1):19-28. Epub 2010 Apr 11.

The Falck Division of Medical Oncology, Ospedale Niguarda Ca' Granda, Milan, Italy.

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http://dx.doi.org/10.1007/s11523-010-0138-5	DOI Listing

March 2010

Biomarkers predicting clinical outcome of epidermal growth factor receptor-targeted therapy in metastatic colorectal cancer.

Authors:

Salvatore Siena Andrea Sartore-Bianchi Federica Di Nicolantonio Julia Balfour Alberto Bardelli

J Natl Cancer Inst 2009 Oct 8;101(19):1308-24. Epub 2009 Sep 8.

The Falck Division of Medical Oncology, Ospedale Niguarda Ca' Granda, Piazza Ospedale Maggiore 3, 20162 Milan, Italy.

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http://jnci.oxfordjournals.org/content/early/2009/09/08/jnci	Web Search
http://jnci.oxfordjournals.org/cgi/doi/10.1093/jnci/djp280	Publisher Site
http://dx.doi.org/10.1093/jnci/djp280	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2758310	PMC

October 2009

Multi-determinants analysis of molecular alterations for predicting clinical benefit to EGFR-targeted monoclonal antibodies in colorectal cancer.

Authors:

Andrea Sartore-Bianchi Federica Di Nicolantonio Michele Nichelatti Francesca Molinari Sara De Dosso Piercarlo Saletti Miriam Martini Tiziana Cipani Giovanna Marrapese Luca Mazzucchelli Simona Lamba Silvio Veronese Milo Frattini Alberto Bardelli Salvatore Siena

PLoS One 2009 Oct 2;4(10):e7287. Epub 2009 Oct 2.

The Falck Division of Medical Oncology, Ospedale Niguarda Ca' Granda, Milan, Italy.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0007287	PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2750753	PMC

October 2009

PIK3CA mutations in colorectal cancer are associated with clinical resistance to EGFR-targeted monoclonal antibodies.

Authors:

Andrea Sartore-Bianchi Miriam Martini Francesca Molinari Silvio Veronese Michele Nichelatti Salvatore Artale Federica Di Nicolantonio Piercarlo Saletti Sara De Dosso Luca Mazzucchelli Milo Frattini Salvatore Siena Alberto Bardelli

Cancer Res 2009 Mar 17;69(5):1851-7. Epub 2009 Feb 17.

The Falck Division of Medical Oncology, Ospedale Niguarda Ca' Granda, Milan, Italy.

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http://dx.doi.org/10.1158/0008-5472.CAN-08-2466	DOI Listing

March 2009

Wild-type BRAF is required for response to panitumumab or cetuximab in metastatic colorectal cancer.

Authors:

Federica Di Nicolantonio Miriam Martini Francesca Molinari Andrea Sartore-Bianchi Sabrina Arena Piercarlo Saletti Sara De Dosso Luca Mazzucchelli Milo Frattini Salvatore Siena Alberto Bardelli

J Clin Oncol 2008 Dec 10;26(35):5705-12. Epub 2008 Nov 10.

Laboratory of Molecular Genetics, The Oncogenomics Center, Institute for Cancer Research and Treatment, University of Torino, Medical School, Candiolo, Torino, Italy.

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