Publications by authors named "Andrea Sartore-Bianchi"

100Publications

The Evolutionary Landscape of Treatment for Mutant Metastatic Colorectal Cancer.

Authors:
Gianluca Mauri Erica Bonazzina Alessio Amatu Federica Tosi Katia Bencardino Viviana Gori Daniela Massihnia Tiziana Cipani Francesco Spina Silvia Ghezzi Salvatore Siena Andrea Sartore-Bianchi

Cancers (Basel) 2021 Jan 4;13(1). Epub 2021 Jan 4.

Niguarda Cancer Center, Grande Ospedale Metropolitano Niguarda, 20162 Milano, Italy.

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January 2021

Impact of inter-reader contouring variability on textural radiomics of colorectal liver metastases.

Authors:
Francesco Rizzetto Francesca Calderoni Cristina De Mattia Arianna Defeudis Valentina Giannini Simone Mazzetti Lorenzo Vassallo Silvia Ghezzi Andrea Sartore-Bianchi Silvia Marsoni Salvatore Siena Daniele Regge Alberto Torresin Angelo Vanzulli

Eur Radiol Exp 2020 11 10;4(1):62. Epub 2020 Nov 10.

Department of Radiology, ASST Grande Ospedale Metropolitano Niguarda, Piazza Ospedale Maggiore 3, 20162, Milan, Italy.

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November 2020

Oxaliplatin retreatment in metastatic colorectal cancer: Systematic review and future research opportunities.

Authors:
Gianluca Mauri Viviana Gori Erica Bonazzina Alessio Amatu Federica Tosi Katia Bencardino Lorenzo Ruggieri Giorgio Patelli Sabrina Arena Alberto Bardelli Salvatore Siena Andrea Sartore-Bianchi

Cancer Treat Rev 2020 Dec 9;91:102112. Epub 2020 Oct 9.

Niguarda Cancer Center, Grande Ospedale Metropolitano Niguarda, Milano, Italy; Dipartimento di Oncologia ed Emato-Oncologia, Università degli Studi di Milano, Milano, Italy. Electronic address:

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December 2020

Pertuzumab and trastuzumab emtansine in patients with HER2-amplified metastatic colorectal cancer: the phase II HERACLES-B trial.

Authors:
Andrea Sartore-Bianchi Sara Lonardi Cosimo Martino Elisabetta Fenocchio Federica Tosi Silvia Ghezzi Francesco Leone Francesca Bergamo Vittorina Zagonel Fortunato Ciardiello Andrea Ardizzoni Alessio Amatu Katia Bencardino Emanuele Valtorta Elena Grassi Valter Torri Emanuela Bonoldi Anna Sapino Angelo Vanzulli Daniele Regge Giovanni Cappello Alberto Bardelli Livio Trusolino Silvia Marsoni Salvatore Siena

ESMO Open 2020 09;5(5)

Niguarda Cancer Center, Grande Ospedale Metropolitano Niguarda, Milano, Italy

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September 2020

Long-term Clinical Outcome of Trastuzumab and Lapatinib for HER2-positive Metastatic Colorectal Cancer.

Authors:
Federica Tosi Andrea Sartore-Bianchi Sara Lonardi Alessio Amatu Francesco Leone Silvia Ghezzi Cosimo Martino Katia Bencardino Erica Bonazzina Francesca Bergamo Elisabetta Fenocchio Erika Martinelli Teresa Troiani Giulia Siravegna Gianluca Mauri Valter Torri Giovanna Marrapese Emanuele Valtorta Andrea Cassingena Giovanni Cappello Emanuela Bonoldi Angelo Vanzulli Daniele Regge Fortunato Ciardiello Vittorina Zagonel Alberto Bardelli Livio Trusolino Silvia Marsoni Salvatore Siena

Clin Colorectal Cancer 2020 Dec 27;19(4):256-262.e2. Epub 2020 Jun 27.

Niguarda Cancer Center, Grande Ospedale Metropolitano Niguarda, Milan, Italy; Dipartimento di Oncologia ed Emato-Oncologia, Università degli Studi di Milano, Milan, Italy. Electronic address:

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December 2020

CDK4/6 Inhibitors in Breast Cancer Treatment: Potential Interactions with Drug, Gene, and Pathophysiological Conditions.

Authors:
Rossana Roncato Jacopo Angelini Arianna Pani Erika Cecchin Andrea Sartore-Bianchi Salvatore Siena Elena De Mattia Francesco Scaglione Giuseppe Toffoli

Int J Mol Sci 2020 Sep 1;21(17). Epub 2020 Sep 1.

Experimental and Clinical Pharmacology Unit, Centro di Riferimento Oncologico (CRO), IRCCS, 33081 Aviano, Italy.

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September 2020

Radiomics predicts response of individual HER2-amplified colorectal cancer liver metastases in patients treated with HER2-targeted therapy.

Authors:
Valentina Giannini Samanta Rosati Arianna Defeudis Gabriella Balestra Lorenzo Vassallo Giovanni Cappello Simone Mazzetti Cristina De Mattia Francesco Rizzetto Alberto Torresin Andrea Sartore-Bianchi Salvatore Siena Angelo Vanzulli Francesco Leone Vittorina Zagonel Silvia Marsoni Daniele Regge

Int J Cancer 2020 Dec 14;147(11):3215-3223. Epub 2020 Sep 14.

Radiology Unit, Candiolo Cancer Institute, FPO-IRCCS, Candiolo, Italy.

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December 2020

Breaking Barriers in HER2+ Cancers.

Authors:
Salvatore Siena Silvia Marsoni Andrea Sartore-Bianchi

Cancer Cell 2020 Sep 27;38(3):317-319. Epub 2020 Aug 27.

Niguarda Cancer Center, Grande Ospedale Metropolitano Niguarda, Milano, Italy; Dipartimento di Oncologia ed Emato-Oncologia, Università degli Studi di Milano (La Statale), Milano, Italy.

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September 2020

Health-related quality of life in patients with RAS wild-type metastatic colorectal cancer treated with panitumumab-based first-line treatment strategy: A pre-specified secondary analysis of the Valentino study.

Authors:
Alessandra Raimondi Massimo Di Maio Federica Morano Salvatore Corallo Sara Lonardi Carlotta Antoniotti Lorenza Rimassa Andrea Sartore-Bianchi Marco Tampellini Giuliana Ritorto Roberto Murialdo Matteo Clavarezza Alberto Zaniboni Vincenzo Adamo Gianluca Tomasello Fausto Petrelli Lorenzo Antonuzzo Monica Giordano Saverio Cinieri Raffaella Longarini Francesca Bergamo Monica Niger Maria Antista Giorgia Peverelli Filippo de Braud Maria Di Bartolomeo Filippo Pietrantonio

Eur J Cancer 2020 08 2;135:230-239. Epub 2020 Jul 2.

Department of Medical Oncology, Fondazione IRCCS Istituto Nazionale Dei Tumori, Milan, Italy; Oncology and Hemato-oncology Department, University of Milan, Milan, Italy. Electronic address:

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August 2020

The Quest for Improving Treatment of Cancer of Unknown Primary (CUP) Through Molecularly-Driven Treatments: A Systematic Review.

Authors:
Roberta Lombardo Federica Tosi Annunziata Nocerino Katia Bencardino Valentina Gambi Riccardo Ricotta Francesco Spina Salvatore Siena Andrea Sartore-Bianchi

Front Oncol 2020 8;10:533. Epub 2020 May 8.

Niguarda Cancer Center, Grande Ospedale Metropolitano Niguarda, Milan, Italy.

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May 2020

The Pan-Immune-Inflammation Value is a new prognostic biomarker in metastatic colorectal cancer: results from a pooled-analysis of the Valentino and TRIBE first-line trials.

Authors:
Giovanni Fucà Vincenzo Guarini Carlotta Antoniotti Federica Morano Roberto Moretto Salvatore Corallo Federica Marmorino Sara Lonardi Lorenza Rimassa Andrea Sartore-Bianchi Beatrice Borelli Marco Tampellini Sara Bustreo Matteo Claravezza Alessandra Boccaccino Roberto Murialdo Alberto Zaniboni Gianluca Tomasello Fotios Loupakis Vincenzo Adamo Giuseppe Tonini Enrico Cortesi Filippo de Braud Chiara Cremolini Filippo Pietrantonio

Br J Cancer 2020 Aug 19;123(3):403-409. Epub 2020 May 19.

Medical Oncology Department, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy.

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August 2020

Central Nervous System as Possible Site of Relapse in ERBB2-Positive Metastatic Colorectal Cancer: Long-term Results of Treatment With Trastuzumab and Lapatinib.

Authors:
Andrea Sartore-Bianchi Sara Lonardi Massimo Aglietta Cosimo Martino Fortunato Ciardiello Silvia Marsoni Salvatore Siena

JAMA Oncol 2020 Jun;6(6):927-929

Niguarda Cancer Center, Grande Ospedale Metropolitano Niguarda, Milan, Italy.

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June 2020

Entrectinib for the treatment of metastatic NSCLC: safety and efficacy.

Authors:
Andrea Sartore-Bianchi Elio Gregory Pizzutilo Giovanna Marrapese Federica Tosi Giulio Cerea Salvatore Siena

Expert Rev Anticancer Ther 2020 05 8;20(5):333-341. Epub 2020 Apr 8.

Niguarda Cancer Center, Grande Ospedale Metropolitano Niguarda, Milan, Italy.

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May 2020

Whole exome sequencing analysis of urine trans-renal tumour DNA in metastatic colorectal cancer patients.

Authors:
Giovanni Crisafulli Benedetta Mussolin Andrea Cassingena Monica Montone Alice Bartolini Ludovic Barault Antonia Martinetti Federica Morano Filippo Pietrantonio Andrea Sartore-Bianchi Salvatore Siena Federica Di Nicolantonio Silvia Marsoni Alberto Bardelli Giulia Siravegna

ESMO Open 2019 11;4(6)

University of Turin, Department of Oncology, Candiolo (TO), Italy

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November 2019

A Subset of Colorectal Cancers with Cross-Sensitivity to Olaparib and Oxaliplatin.

Authors:
Sabrina Arena Giorgio Corti Erika Durinikova Monica Montone Nicole M Reilly Mariangela Russo Annalisa Lorenzato Pamela Arcella Luca Lazzari Giuseppe Rospo Massimiliano Pagani Carlotta Cancelliere Carola Negrino Claudio Isella Alice Bartolini Andrea Cassingena Alessio Amatu Gianluca Mauri Andrea Sartore-Bianchi Gloria Mittica Enzo Medico Silvia Marsoni Michael Linnebacher Sergio Abrignani Salvatore Siena Federica Di Nicolantonio Alberto Bardelli

Clin Cancer Res 2020 03 12;26(6):1372-1384. Epub 2019 Dec 12.

Candiolo Cancer Institute, FPO - IRCCS, Candiolo, Torino, Italy.

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March 2020

Capecitabine and Temozolomide versus FOLFIRI in RAS-Mutated, MGMT-Methylated Metastatic Colorectal Cancer.

Authors:
Filippo Pietrantonio Riccardo Lobefaro Maria Antista Sara Lonardi Alessandra Raimondi Federica Morano Stefania Mosconi Lorenza Rimassa Sabina Murgioni Andrea Sartore-Bianchi Gianluca Tomasello Raffaella Longarini Gabriella Farina Fausto Petrelli Stefania Gori Giovanni Randon Salvatore Corallo Filippo Pagani Vincenzo Guarini Federica Palermo Antonia Martinetti Marco Macagno Ludovic Barault Federica Perrone Elena Tamborini Massimo Milione Federica Di Nicolantonio Massimo Di Maio Giovanni Fucà Maria Di Bartolomeo Filippo de Braud

Clin Cancer Res 2020 03 18;26(5):1017-1024. Epub 2019 Nov 18.

Oncology and Hemato-oncology Department, University of Milan, Milan, Italy.

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March 2020

Adaptive mutability of colorectal cancers in response to targeted therapies.

Authors:
Mariangela Russo Giovanni Crisafulli Alberto Sogari Nicole M Reilly Sabrina Arena Simona Lamba Alice Bartolini Vito Amodio Alessandro Magrì Luca Novara Ivana Sarotto Zachary D Nagel Cortt G Piett Alessio Amatu Andrea Sartore-Bianchi Salvatore Siena Andrea Bertotti Livio Trusolino Mattia Corigliano Marco Gherardi Marco Cosentino Lagomarsino Federica Di Nicolantonio Alberto Bardelli

Science 2019 12 7;366(6472):1473-1480. Epub 2019 Nov 7.

Candiolo Cancer Institute, FPO-IRCCS, Candiolo (TO) 10060, Italy.

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December 2019

A Comprehensive PDX Gastric Cancer Collection Captures Cancer Cell-Intrinsic Transcriptional MSI Traits.

Authors:
Simona Corso Claudio Isella Sara E Bellomo Maria Apicella Stefania Durando Cristina Migliore Stefano Ughetto Laura D'Errico Silvia Menegon Daniel Moya-Rull Marilisa Cargnelutti Tânia Capelôa Daniela Conticelli Jessica Giordano Tiziana Venesio Antonella Balsamo Caterina Marchiò Maurizio Degiuli Rossella Reddavid Uberto Fumagalli Stefano De Pascale Giovanni Sgroi Emanuele Rausa Gian Luca Baiocchi Sarah Molfino Filippo Pietrantonio Federica Morano Salvatore Siena Andrea Sartore-Bianchi Maria Bencivenga Valentina Mengardo Riccardo Rosati Daniele Marrelli Paolo Morgagni Stefano Rausei Giovanni Pallabazzer Michele De Simone Dario Ribero Silvia Marsoni Antonino Sottile Enzo Medico Paola Cassoni Anna Sapino Eirini Pectasides Aaron R Thorner Anwesha Nag Samantha D Drinan Bruce M Wollison Adam J Bass Silvia Giordano

Cancer Res 2019 11 4;79(22):5884-5896. Epub 2019 Oct 4.

Department of Oncology, University of Torino, Candiolo, Italy.

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November 2019

Negative Hyperselection of Patients With and Wild-Type Metastatic Colorectal Cancer Who Received Panitumumab-Based Maintenance Therapy.

Authors:
Federica Morano Salvatore Corallo Sara Lonardi Alessandra Raimondi Chiara Cremolini Lorenza Rimassa Roberto Murialdo Alberto Zaniboni Andrea Sartore-Bianchi Gianluca Tomasello Patrizia Racca Matteo Clavarezza Vincenzo Adamo Federica Perrone Annunziata Gloghini Elena Tamborini Adele Busico Antonia Martinetti Federica Palermo Fotios Loupakis Massimo Milione Giovanni Fucà Maria Di Bartolomeo Filippo de Braud Filippo Pietrantonio

J Clin Oncol 2019 11 20;37(33):3099-3110. Epub 2019 Sep 20.

Fondazione Instituto di Ricovero e Cura Carattere Scientifico (IRCCS) Istituto Nazionale dei Tumori, Milan, Italy.

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November 2019

Liquid biopsy for rectal cancer: A systematic review.

Authors:
Daniela Massihnia Elio Gregory Pizzutilo Alessio Amatu Federica Tosi Silvia Ghezzi Katia Bencardino Pietro Di Masi Elena Righetti Giorgio Patelli Francesco Scaglione Angelo Vanzulli Salvatore Siena Andrea Sartore-Bianchi

Cancer Treat Rev 2019 Sep 31;79:101893. Epub 2019 Aug 31.

Niguarda Cancer Center, Grande Ospedale Metropolitano Niguarda, Milan, Italy; Università degli Studi di Milano, Department of Oncology and Hemato-Oncology, Milan, Italy. Electronic address:

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September 2019

The Amount of Evidence Needed to Support ERBB2 as a Biomarker for Resistance to EGFR Inhibitors in Metastatic Colorectal Cancer.

Authors:
Andrea Sartore-Bianchi Silvia Marsoni Salvatore Siena

JAMA Oncol 2019 Aug 15. Epub 2019 Aug 15.

Niguarda Cancer Center, Grande Ospedale Metropolitano Niguarda, Milan, Italy.

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August 2019

Patient-Derived Xenografts and Matched Cell Lines Identify Pharmacogenomic Vulnerabilities in Colorectal Cancer.

Authors:
Luca Lazzari Giorgio Corti Gabriele Picco Claudio Isella Monica Montone Pamela Arcella Erika Durinikova Eugenia R Zanella Luca Novara Fabiane Barbosa Andrea Cassingena Carlotta Cancelliere Enzo Medico Andrea Sartore-Bianchi Salvatore Siena Mathew J Garnett Andrea Bertotti Livio Trusolino Federica Di Nicolantonio Michael Linnebacher Alberto Bardelli Sabrina Arena

Clin Cancer Res 2019 10 2;25(20):6243-6259. Epub 2019 Aug 2.

Department of Oncology, University of Torino, Candiolo, Torino, Italy.

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October 2019

High Circulating Methylated DNA Is a Negative Predictive and Prognostic Marker in Metastatic Colorectal Cancer Patients Treated With Regorafenib.

Authors:
Alessio Amatu Marta Schirripa Federica Tosi Sara Lonardi Katia Bencardino Erica Bonazzina Laura Palmeri Damiano Alfio Patanè Elio Gregory Pizzutilo Benedetta Mussolin Francesca Bergamo Giulia Alberti Rossana Intini Letizia Procaccio Marco Arese Silvia Marsoni Michele Nichelatti Vittorina Zagonel Salvatore Siena Alberto Bardelli Fotios Loupakis Federica Di Nicolantonio Andrea Sartore-Bianchi Ludovic Barault

Front Oncol 2019 12;9:622. Epub 2019 Jul 12.

Candiolo Cancer Institute, FPO-IRCCS, Candiolo, Italy.

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July 2019

The Evolving Biomarker Landscape for Treatment Selection in Metastatic Colorectal Cancer.

Authors:
Julien Taieb Andreas Jung Andrea Sartore-Bianchi Marc Peeters Jenny Seligmann Aziz Zaanan Peter Burdon Clara Montagut Pierre Laurent-Puig

Drugs 2019 Sep;79(13):1375-1394

Sorbonne Paris Cité, Paris Descartes University, Georges Pompidou European Hospital, Paris, France.

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September 2019

A validated prognostic classifier for BRAF-mutated metastatic colorectal cancer: the 'BRAF BeCool' study.

Authors:
Fotios Loupakis Rossana Intini Chiara Cremolini Armando Orlandi Andrea Sartore-Bianchi Filippo Pietrantonio Nicoletta Pella Andrea Spallanzani Emanuela Dell'Aquila Mario Scartozzi Emmanuele De Luca Lorenza Rimassa Vincenzo Formica Francesco Leone Lorenzo Calvetti Giuseppe Aprile Lorenzo Antonuzzo Federica Urbano Hans Prenen Francesca Negri Samantha Di Donato Pasquale Buonandi Gianluca Tomasello Antonio Avallone Fable Zustovich Roberto Moretto Carlotta Antoniotti Lisa Salvatore Maria Alessandra Calegari Salvatore Siena Federica Morano Elena Ongaro Stefano Cascinu Daniele Santini Pina Ziranu Marta Schirripa Federica Buggin Alessandra Anna Prete Ilaria Depetris Paola Biason Sara Lonardi Vittorina Zagonel Matteo Fassan Massimo Di Maio

Eur J Cancer 2019 09 19;118:121-130. Epub 2019 Jul 19.

S.C.D.U. Medical Oncology, A.O. Ordine Mauriziano Hospital, Department of Oncology, University of Turin, Turin, Italy.

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September 2019

Maintenance Therapy With Panitumumab Alone vs Panitumumab Plus Fluorouracil-Leucovorin in Patients With RAS Wild-Type Metastatic Colorectal Cancer: A Phase 2 Randomized Clinical Trial.

Authors:
Filippo Pietrantonio Federica Morano Salvatore Corallo Rosalba Miceli Sara Lonardi Alessandra Raimondi Chiara Cremolini Lorenza Rimassa Francesca Bergamo Andrea Sartore-Bianchi Marco Tampellini Patrizia Racca Matteo Clavarezza Rosa Berenato Marta Caporale Maria Antista Monica Niger Valeria Smiroldo Roberto Murialdo Alberto Zaniboni Vincenzo Adamo Gianluca Tomasello Monica Giordano Fausto Petrelli Raffaella Longarini Saverio Cinieri Alfredo Falcone Vittorina Zagonel Maria Di Bartolomeo Filippo de Braud

JAMA Oncol 2019 Jul 3. Epub 2019 Jul 3.

Oncology and Hemato-oncology Department, University of Milan, Milan, Italy.

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July 2019

HER2 Positivity Predicts Unresponsiveness to EGFR-Targeted Treatment in Metastatic Colorectal Cancer.

Authors:
Andrea Sartore-Bianchi Alessio Amatu Luca Porcu Silvia Ghezzi Sara Lonardi Francesco Leone Francesca Bergamo Elisabetta Fenocchio Erika Martinelli Beatrice Borelli Federica Tosi Patrizia Racca Emanuele Valtorta Emanuela Bonoldi Cosimo Martino Caterina Vaghi Giovanna Marrapese Fortunato Ciardiello Vittorina Zagonel Alberto Bardelli Livio Trusolino Valter Torri Silvia Marsoni Salvatore Siena

Oncologist 2019 10 5;24(10):1395-1402. Epub 2019 Apr 5.

Niguarda Cancer Center, Grande Ospedale Metropolitano Niguarda, Milan, Italy

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October 2019

Plasma HER2 () Copy Number Predicts Response to HER2-targeted Therapy in Metastatic Colorectal Cancer.

Authors:
Giulia Siravegna Andrea Sartore-Bianchi Rebecca J Nagy Kanwal Raghav Justin I Odegaard Richard B Lanman Livio Trusolino Silvia Marsoni Salvatore Siena Alberto Bardelli

Clin Cancer Res 2019 05 26;25(10):3046-3053. Epub 2019 Feb 26.

Candiolo Cancer Institute, FPO-IRCCS, Candiolo, Torino, Italy.

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May 2019

Combined Low Densities of FoxP3 and CD3 Tumor-Infiltrating Lymphocytes Identify Stage II Colorectal Cancer at High Risk of Progression.

Authors:
Tommaso Cavalleri Paolo Bianchi Gianluca Basso Giuseppe Celesti Fabio Grizzi Paola Bossi Luana Greco Calogero Pitrone Emanuele Valtorta Gianluca Mauri Mauro Truini Filippo Gustavo Dall'Olio Giovanni Brandi Andrea Sartore-Bianchi Luigi Ricciardiello Valter Torri Lorenza Rimassa Salvatore Siena Alberto Mantovani Alberto Malesci Luigi Laghi

Cancer Immunol Res 2019 05 25;7(5):751-758. Epub 2019 Feb 25.

Department of Internal Medicine, Humanitas University, Pieve Emanuele, Milan, Italy

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May 2019

Retreatment with anti-EGFR monoclonal antibodies in metastatic colorectal cancer: Systematic review of different strategies.

Authors:
Gianluca Mauri Elio Gregory Pizzutilo Alessio Amatu Katia Bencardino Laura Palmeri Erica Francesca Bonazzina Federica Tosi Giulia Carlo Stella Giovanni Burrafato Francesco Scaglione Silvia Marsoni Giulia Siravegna Alberto Bardelli Salvatore Siena Andrea Sartore-Bianchi

Cancer Treat Rev 2019 Feb 27;73:41-53. Epub 2018 Dec 27.

Niguarda Cancer Center, Grande Ospedale Metropolitano Niguarda, Milan, Italy; Università degli Studi di Milano, Dipartimento di Oncologia ed Emato-Oncologia, Milano, Italy. Electronic address:

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February 2019

Third- or Later-line Therapy for Metastatic Colorectal Cancer: Reviewing Best Practice.

Authors:
Tanios Bekaii-Saab Richard Kim Tae Won Kim Juan Manuel O'Connor John H Strickler David Malka Andrea Sartore-Bianchi Feng Bi Kensei Yamaguchi Takayuki Yoshino Gerald W Prager

Clin Colorectal Cancer 2019 03 16;18(1):e117-e129. Epub 2018 Nov 16.

Department of Medicine I, Comprehensive Cancer Center Vienna, Medical University Vienna, Vienna, Austria. Electronic address:

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March 2019

Early-onset colorectal cancer in young individuals.

Authors:
Gianluca Mauri Andrea Sartore-Bianchi Antonio-Giampiero Russo Silvia Marsoni Alberto Bardelli Salvatore Siena

Mol Oncol 2019 02 22;13(2):109-131. Epub 2018 Dec 22.

Niguarda Cancer Center, Grande Ospedale Metropolitano Niguarda, Dipartimento di Oncologia e Emato-Oncologia, Università degli Studi di Milano (La Statale), Milan, Italy.

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February 2019

Radiologic and Genomic Evolution of Individual Metastases during HER2 Blockade in Colorectal Cancer.

Authors:
Giulia Siravegna Luca Lazzari Giovanni Crisafulli Andrea Sartore-Bianchi Benedetta Mussolin Andrea Cassingena Cosimo Martino Richard B Lanman Rebecca J Nagy Stephen Fairclough Giuseppe Rospo Giorgio Corti Alice Bartolini Pamela Arcella Monica Montone Francesca Lodi Annalisa Lorenzato Alice Vanzati Emanuele Valtorta Giovanni Cappello Andrea Bertotti Sara Lonardi Vittorina Zagonel Francesco Leone Mariangela Russo Antonella Balsamo Mauro Truini Federica Di Nicolantonio Alessio Amatu Erica Bonazzina Silvia Ghezzi Daniele Regge Angelo Vanzulli Livio Trusolino Salvatore Siena Silvia Marsoni Alberto Bardelli

Cancer Cell 2018 07;34(1):148-162.e7

Candiolo Cancer Institute-FPO, IRCCS, Candiolo, TO, Italy; Department of Oncology, University of Torino, Candiolo, TO 10060, Italy. Electronic address:

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July 2018

Reliance upon ancestral mutations is maintained in colorectal cancers that heterogeneously evolve during targeted therapies.

Authors:
Mariangela Russo Simona Lamba Annalisa Lorenzato Alberto Sogari Giorgio Corti Giuseppe Rospo Benedetta Mussolin Monica Montone Luca Lazzari Sabrina Arena Daniele Oddo Michael Linnebacher Andrea Sartore-Bianchi Filippo Pietrantonio Salvatore Siena Federica Di Nicolantonio Alberto Bardelli

Nat Commun 2018 06 12;9(1):2287. Epub 2018 Jun 12.

Candiolo Cancer Institute-FPO, IRCCS, 10060, Candiolo, Turin, Italy.

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June 2018

TRKA expression and gene copy number across solid tumours.

Authors:
Gianluca Mauri Emanuele Valtorta Giulio Cerea Alessio Amatu Michele Schirru Giovanna Marrapese Vincenzo Fiorillo Patrizia Recchimuzzo Ivana Stella Cavenago Erica Francesca Bonazzina Valentina Motta Calogero Lauricella Silvio Veronese Federica Tosi Martina Maiolani Giuseppe Rospo Mauro Truini Emanuela Bonoldi Jason Christiansen Steven J Potts Salvatore Siena Andrea Sartore-Bianchi

J Clin Pathol 2018 Oct 25;71(10):926-931. Epub 2018 May 25.

Niguarda Cancer Center, Grande Ospedale Metropolitano Niguarda, Milan, Italy.

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October 2018

Sequential HER2 blockade as effective therapy in chemorefractory, HER2 gene-amplified, RAS wild-type, metastatic colorectal cancer: learning from a clinical case.

Authors:
Erika Martinelli Teresa Troiani Vincenzo Sforza Giulia Martini Claudia Cardone Pietro Paolo Vitiello Davide Ciardiello Anna Maria Rachiglio Nicola Normanno Andrea Sartore-Bianchi Silvia Marsoni Alberto Bardelli Salvatore Siena Fortunato Ciardiello

ESMO Open 2018 10;3(1):e000299. Epub 2018 Jan 10.

Dipartimento di Internistica Clinica e Sperimentale 'F Magrassi', Università degli Studi della Campania L Vanvitelli, Napoli, Italy.

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January 2018

ALK, ROS1, and NTRK Rearrangements in Metastatic Colorectal Cancer.

Authors:
Filippo Pietrantonio Federica Di Nicolantonio Alexa B Schrock Jeeyun Lee Sabine Tejpar Andrea Sartore-Bianchi Jaclyn F Hechtman Jason Christiansen Luca Novara Niall Tebbutt Giovanni Fucà Carlotta Antoniotti Seung Tae Kim Danielle Murphy Rosa Berenato Federica Morano James Sun Bosun Min Philip J Stephens Marissa Chen Luca Lazzari Vincent A Miller Robert Shoemaker Alessio Amatu Massimo Milione Jeffrey S Ross Salvatore Siena Alberto Bardelli Siraj M Ali Alfredo Falcone Filippo de Braud Chiara Cremolini

J Natl Cancer Inst 2017 12;109(12)

Azienda Ospedaliero, Universitaria Pisana, Pisa, Italy.

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December 2017

Parallel Evaluation of Circulating Tumor DNA and Circulating Tumor Cells in Metastatic Colorectal Cancer.

Authors:
Giovanni Germano Gianluca Mauri Giulia Siravegna Caroline Dive Jackie Pierce Federica Di Nicolantonio Maurizio D'Incalci Alberto Bardelli Salvatore Siena Andrea Sartore-Bianchi

Clin Colorectal Cancer 2018 03 1;17(1):80-83. Epub 2017 Nov 1.

Niguarda Cancer Center, Grande Ospedale Metropolitano Niguarda, Milan, Italy. Electronic address:

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March 2018

Inactivation of DNA repair triggers neoantigen generation and impairs tumour growth.

Authors:
Giovanni Germano Simona Lamba Giuseppe Rospo Ludovic Barault Alessandro Magrì Federica Maione Mariangela Russo Giovanni Crisafulli Alice Bartolini Giulia Lerda Giulia Siravegna Benedetta Mussolin Roberta Frapolli Monica Montone Federica Morano Filippo de Braud Nabil Amirouchene-Angelozzi Silvia Marsoni Maurizio D'Incalci Armando Orlandi Enrico Giraudo Andrea Sartore-Bianchi Salvatore Siena Filippo Pietrantonio Federica Di Nicolantonio Alberto Bardelli

Nature 2017 12 29;552(7683):116-120. Epub 2017 Nov 29.

Candiolo Cancer Institute - FPO, IRCCS, Candiolo 10060, Turin, Italy.

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December 2017

Human Epidermal Growth Factor Receptor 2 as a Molecular Biomarker for Metastatic Colorectal Cancer.

Authors:
Andrea Sartore-Bianchi Silvia Marsoni Salvatore Siena

JAMA Oncol 2018 Jan;4(1):19-20

Niguarda Cancer Center, Grande Ospedale Metropolitano Niguarda, Milan, Italy.

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January 2018

Discovery of methylated circulating DNA biomarkers for comprehensive non-invasive monitoring of treatment response in metastatic colorectal cancer.

Authors:
Ludovic Barault Alessio Amatu Giulia Siravegna Agostino Ponzetti Sebastian Moran Andrea Cassingena Benedetta Mussolin Chiara Falcomatà Alexandra M Binder Carmen Cristiano Daniele Oddo Simonetta Guarrera Carlotta Cancelliere Sara Bustreo Katia Bencardino Sean Maden Alice Vanzati Patrizia Zavattari Giuseppe Matullo Mauro Truini William M Grady Patrizia Racca Karin B Michels Salvatore Siena Manel Esteller Alberto Bardelli Andrea Sartore-Bianchi Federica Di Nicolantonio

Gut 2018 11 5;67(11):1995-2005. Epub 2017 Oct 5.

Department of Oncology, University of Torino, Torino, Italy.

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November 2018

Radiological imaging markers predicting clinical outcome in patients with metastatic colorectal carcinoma treated with regorafenib: post hoc analysis of the CORRECT phase III trial (RadioCORRECT study).

Authors:
Riccardo Ricotta Antonella Verrioli Silvia Ghezzi Luca Porcu A Grothey Alfredo Falcone Eric Van Cutsem Guillem Argilés Antoine Adenis Marc Ychou Carlo Barone Olivier Bouché Marc Peeters Yves Humblet Laurent Mineur Alberto F Sobrero Joleen M Hubbard Chiara Cremolini Hans Prenen Josep Tabernero Hajer Jarraya Thibault Mazard Sophie Deguelte-Lardiere Konstantinos Papadimitriou Marc Van den Eynde Alessandro Pastorino Daniela Redaelli Katia Bencardino Chiara Funaioli Alessio Amatu Giulia Carlo-Stella Valter Torri Andrea Sartore-Bianchi Angelo Vanzulli Salvatore Siena

ESMO Open 2016 13;1(6):e000111. Epub 2017 Feb 13.

Niguarda Cancer Center, Grande Ospedale Metropolitano Niguarda, Milan, Italy.

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February 2017

Pooled Analysis of Clinical Outcome of Patients with Chemorefractory Metastatic Colorectal Cancer Treated within Phase I/II Clinical Studies Based on Individual Biomarkers of Susceptibility: A Single-Institution Experience.

Authors:
Andrea Sartore-Bianchi Alessio Amatu Erica Bonazzina Stefano Stabile Laura Giannetta Giulio Cerea Ilaria Schiavetto Katia Bencardino Chiara Funaioli Riccardo Ricotta Tiziana Cipani Michele Schirru Valentina Gambi Laura Palmeri Giulia Carlo-Stella Francesca Rusconi Sara Di Bella Giovanni Burrafato Andrea Cassingena Emanuele Valtorta Calogero Lauricella Federica Pazzi Alessandra Gambaro Silvia Ghezzi Giovanna Marrapese Emiliana Tarenzi Silvio Veronese Mauro Truini Angelo Vanzulli Salvatore Siena

Target Oncol 2017 08;12(4):525-533

Niguarda Cancer Center, Grande Ospedale Metropolitano Niguarda, Piazza Ospedale Maggiore, 3, 20162, Milan, Italy.

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August 2017

Plasticity of Resistance and Sensitivity to Anti-Epidermal Growth Factor Receptor Inhibitors in Metastatic Colorectal Cancer.

Authors:
Andrea Sartore-Bianchi Salvatore Siena

Handb Exp Pharmacol 2018;249:145-159

Niguarda Cancer Center, Grande Ospedale Metropolitano Niguarda, Piazza Ospedale Maggiore, 3, 20162, Milan, Italy.

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June 2019

Effect of KRAS and BRAF Mutations on Survival of Metastatic Colorectal Cancer After Liver Resection: A Systematic Review and Meta-Analysis.

Authors:
Federica Tosi Elena Magni Alessio Amatu Gianluca Mauri Katia Bencardino Mauro Truini Silvio Veronese Luciano De Carlis Giovanni Ferrari Michele Nichelatti Andrea Sartore-Bianchi Salvatore Siena

Clin Colorectal Cancer 2017 09 25;16(3):e153-e163. Epub 2017 Jan 25.

Niguarda Cancer Center, Grande Ospedale Metropolitano Niguarda, Milano, Italy; Dipartimento di Oncologia e Emato-Oncologia, Università degli Studi di Milano, Milano, Italy.

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September 2017

Safety and Antitumor Activity of the Multitargeted Pan-TRK, ROS1, and ALK Inhibitor Entrectinib: Combined Results from Two Phase I Trials (ALKA-372-001 and STARTRK-1).

Authors:
Alexander Drilon Salvatore Siena Sai-Hong Ignatius Ou Manish Patel Myung Ju Ahn Jeeyun Lee Todd M Bauer Anna F Farago Jennifer J Wheler Stephen V Liu Robert Doebele Laura Giannetta Giulio Cerea Giovanna Marrapese Michele Schirru Alessio Amatu Katia Bencardino Laura Palmeri Andrea Sartore-Bianchi Angelo Vanzulli Sara Cresta Silvia Damian Matteo Duca Elena Ardini Gang Li Jason Christiansen Karey Kowalski Ann D Johnson Rupal Patel David Luo Edna Chow-Maneval Zachary Hornby Pratik S Multani Alice T Shaw Filippo G De Braud

Cancer Discov 2017 04 9;7(4):400-409. Epub 2017 Feb 9.

Dipartimento di Oncologia e Emato-Oncologia, Università degli Studi di Milano, Milan, Italy.

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April 2017

Mutation-Enrichment Next-Generation Sequencing for Quantitative Detection of Mutations in Urine Cell-Free DNA from Patients with Advanced Cancers.

Authors:
Takeo Fujii Afsaneh Barzi Andrea Sartore-Bianchi Andrea Cassingena Giulia Siravegna Daniel D Karp Sarina A Piha-Paul Vivek Subbiah Apostolia M Tsimberidou Helen J Huang Silvio Veronese Federica Di Nicolantonio Sandeep Pingle Cecile Rose T Vibat Saege Hancock David Berz Vladislava O Melnikova Mark G Erlander Rajyalakshmi Luthra E Scott Kopetz Funda Meric-Bernstam Salvatore Siena Heinz-Josef Lenz Alberto Bardelli Filip Janku

Clin Cancer Res 2017 Jul 17;23(14):3657-3666. Epub 2017 Jan 17.

Department of Investigational Cancer Therapeutics (Phase I Clinical Trials Program), The University of Texas MD Anderson Cancer Center, Houston, Texas.

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July 2017

Molecular Markers Beyond Microsatellite Instability for Assessing Prognosis in Early-Stage Colorectal Cancer: What Happens at Relapse?

Authors:
Andrea Sartore-Bianchi

JAMA Oncol 2017 04;3(4):481-482

Department of Hematology and Oncology, Niguarda Cancer Center, Grande Ospedale Metropolitano Niguarda, Milano, Italy.

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April 2017

Digital PCR assessment of MGMT promoter methylation coupled with reduced protein expression optimises prediction of response to alkylating agents in metastatic colorectal cancer patients.

Authors:
Andrea Sartore-Bianchi Filippo Pietrantonio Alessio Amatu Massimo Milione Andrea Cassingena Silvia Ghezzi Marta Caporale Rosa Berenato Chiara Falcomatà Alessio Pellegrinelli Alberto Bardelli Michele Nichelatti Federica Tosi Filippo De Braud Federica Di Nicolantonio Ludovic Barault Salvatore Siena

Eur J Cancer 2017 01 18;71:43-50. Epub 2016 Dec 18.

Niguarda Cancer Center, Grande Ospedale Metropolitano Niguarda, Milan, Italy; Università degli Studi di Milano, Milan, Italy.

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January 2017

Acquired RAS or EGFR mutations and duration of response to EGFR blockade in colorectal cancer.

Authors:
Beth O Van Emburgh Sabrina Arena Giulia Siravegna Luca Lazzari Giovanni Crisafulli Giorgio Corti Benedetta Mussolin Federica Baldi Michela Buscarino Alice Bartolini Emanuele Valtorta Joana Vidal Beatriz Bellosillo Giovanni Germano Filippo Pietrantonio Agostino Ponzetti Joan Albanell Salvatore Siena Andrea Sartore-Bianchi Federica Di Nicolantonio Clara Montagut Alberto Bardelli

Nat Commun 2016 12 8;7:13665. Epub 2016 Dec 8.

Candiolo Cancer Institute-FPO, IRCCS, 10060 Candiolo, Torino, Italy.

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December 2016

Overcoming dynamic molecular heterogeneity in metastatic colorectal cancer: Multikinase inhibition with regorafenib and the case of rechallenge with anti-EGFR.

Authors:
Andrea Sartore-Bianchi Salvatore Siena Giuseppe Tonini Alberto Bardelli Daniele Santini

Cancer Treat Rev 2016 Dec 29;51:54-62. Epub 2016 Oct 29.

Department of Medical Oncology, Campus Bio-Medico University of Rome, 00128 Rome, Italy. Electronic address:

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December 2016

Clonal evolution and - coamplification during secondary resistance to EGFR-targeted therapy in metastatic colorectal cancer.

Authors:
Andrea Sartore-Bianchi Emanuele Valtorta Alessio Amatu Silvio Veronese Calogero Lauricella Erica Bonazzina Giulia Siravegna Mauro Truini Alberto Bardelli Salvatore Siena

ESMO Open 2016 4;1(4):e000079. Epub 2016 Aug 4.

Niguarda Cancer Center, Grande Ospedale Metropolitano Niguarda, Milano, Italy; Dipartimento di Oncologia e Emato-Oncologia, Università degli Studi di Milano, Milano, Italy.

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August 2016

gene fusions as novel targets of cancer therapy across multiple tumour types.

Authors:
Alessio Amatu Andrea Sartore-Bianchi Salvatore Siena

ESMO Open 2016 18;1(2):e000023. Epub 2016 Mar 18.

Niguarda Cancer Center, Grande Ospedale Metropolitano Niguarda, Milan, Italy; Dipartimento di Oncologia e Emato-Oncologia, Università degli Studi di Milano, Milan, Italy.

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March 2016

Molecular Landscape of Acquired Resistance to Targeted Therapy Combinations in BRAF-Mutant Colorectal Cancer.

Authors:
Daniele Oddo Erin M Sennott Ludovic Barault Emanuele Valtorta Sabrina Arena Andrea Cassingena Genny Filiciotto Giulia Marzolla Elena Elez Robin M J M van Geel Alice Bartolini Giovanni Crisafulli Valentina Boscaro Jason T Godfrey Michela Buscarino Carlotta Cancelliere Michael Linnebacher Giorgio Corti Mauro Truini Giulia Siravegna Julieta Grasselli Margherita Gallicchio René Bernards Jan H M Schellens Josep Tabernero Jeffrey A Engelman Andrea Sartore-Bianchi Alberto Bardelli Salvatore Siena Ryan B Corcoran Federica Di Nicolantonio

Cancer Res 2016 08 16;76(15):4504-15. Epub 2016 Jun 16.

Department of Oncology, University of Torino, Candiolo, Torino, Italy. Candiolo Cancer Institute-FPO, IRCCS, Candiolo, Torino, Italy.

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August 2016

Dual-targeted therapy with trastuzumab and lapatinib in treatment-refractory, KRAS codon 12/13 wild-type, HER2-positive metastatic colorectal cancer (HERACLES): a proof-of-concept, multicentre, open-label, phase 2 trial.

Authors:
Andrea Sartore-Bianchi Livio Trusolino Cosimo Martino Katia Bencardino Sara Lonardi Francesca Bergamo Vittorina Zagonel Francesco Leone Ilaria Depetris Erika Martinelli Teresa Troiani Fortunato Ciardiello Patrizia Racca Andrea Bertotti Giulia Siravegna Valter Torri Alessio Amatu Silvia Ghezzi Giovanna Marrapese Laura Palmeri Emanuele Valtorta Andrea Cassingena Calogero Lauricella Angelo Vanzulli Daniele Regge Silvio Veronese Paolo M Comoglio Alberto Bardelli Silvia Marsoni Salvatore Siena

Lancet Oncol 2016 Jun 20;17(6):738-746. Epub 2016 Apr 20.

Niguarda Cancer Center, Grande Ospedale Metropolitano Niguarda, Milano, Italy; Dipartimento di Oncologia e Emato-Oncologia Università degli Studi di Milano, Milano, Italy.

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June 2016

Oxaliplatin Immune-Induced Syndrome Occurs With Cumulative Administration and Rechallenge: Single Institution Series and Systematic Review Study.

Authors:
Katia Bencardino Gianluca Mauri Alessio Amatu Federica Tosi Erica Bonazzina Laura Palmeri Marialuisa Querques Federica Ravera Alberto Menegotto Elisa Boiani Andrea Sartore-Bianchi Salvatore Siena

Clin Colorectal Cancer 2016 09 19;15(3):213-21. Epub 2016 Feb 19.

Niguarda Cancer Center, Grande Ospedale Metropolitano Niguarda, Milan, Italy; Dipartimento di Oncologia e Emato-Oncologia, Università degli Studi di Milano, Milan, Italy.

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September 2016

Tumor Heterogeneity and Lesion-Specific Response to Targeted Therapy in Colorectal Cancer.

Authors:
Mariangela Russo Giulia Siravegna Lawrence S Blaszkowsky Giorgio Corti Giovanni Crisafulli Leanne G Ahronian Benedetta Mussolin Eunice L Kwak Michela Buscarino Luca Lazzari Emanuele Valtorta Mauro Truini Nicholas A Jessop Hayley E Robinson Theodore S Hong Mari Mino-Kenudson Federica Di Nicolantonio Ashraf Thabet Andrea Sartore-Bianchi Salvatore Siena A John Iafrate Alberto Bardelli Ryan B Corcoran

Cancer Discov 2016 Feb 7;6(2):147-153. Epub 2015 Dec 7.

Massachusetts General Hospital Cancer Center, Boston, MA, USA.

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February 2016

Novel CAD-ALK gene rearrangement is drugable by entrectinib in colorectal cancer.

Authors:
Alessio Amatu Alessio Somaschini Giulio Cerea Roberta Bosotti Emanuele Valtorta Pasquale Buonandi Giovanna Marrapese Silvio Veronese David Luo Zachary Hornby Pratik Multani Danielle Murphy Robert Shoemaker Calogero Lauricella Laura Giannetta Martina Maiolani Angelo Vanzulli Elena Ardini Arturo Galvani Antonella Isacchi Andrea Sartore-Bianchi Salvatore Siena

Br J Cancer 2015 Dec 3;113(12):1730-4. Epub 2015 Dec 3.

Niguarda Cancer Center, Ospedale Niguarda Ca' Granda, 20162 Milan, Italy.

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December 2015

Sensitivity to Entrectinib Associated With a Novel LMNA-NTRK1 Gene Fusion in Metastatic Colorectal Cancer.

Authors:
Andrea Sartore-Bianchi Elena Ardini Roberta Bosotti Alessio Amatu Emanuele Valtorta Alessio Somaschini Laura Raddrizzani Laura Palmeri Patrizia Banfi Erica Bonazzina Sandra Misale Giovanna Marrapese Antonella Leone Rachele Alzani David Luo Zachary Hornby Jonathan Lim Silvio Veronese Angelo Vanzulli Alberto Bardelli Marcella Martignoni Cristina Davite Arturo Galvani Antonella Isacchi Salvatore Siena

J Natl Cancer Inst 2016 Jan 12;108(1). Epub 2015 Nov 12.

Niguarda Cancer Center, Ospedale Niguarda Ca' Granda, Milan, Italy (ASB, AA, EV, LP, EB, GM, SV, AV, SS); Nerviano Medical Sciences S.r.l Nerviano, Milan, Italy (EA, RB, AS, LR, PB, AL, RA, AG, AI); Candiolo Cancer Institute - FPO, IRCCS, Candiolo, Torino, Italy (SM, AB); University of Torino, Department of Oncology, Candiolo, Torino, Italy (AB); FIRC Institute of Molecular Oncology (IFOM), Milano, Italy (SM); Ignyta, Inc., San Diego, CA (DL, ZH, JL); Clioss S.r.l. Nerviano, Milan, Italy (MM, CD); Università degli Studi di Milano, Milan, Italy (SS).

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January 2016

Acquired Resistance to the TRK Inhibitor Entrectinib in Colorectal Cancer.

Authors:
Mariangela Russo Sandra Misale Ge Wei Giulia Siravegna Giovanni Crisafulli Luca Lazzari Giorgio Corti Giuseppe Rospo Luca Novara Benedetta Mussolin Alice Bartolini Nicholas Cam Roopal Patel Shunqi Yan Robert Shoemaker Robert Wild Federica Di Nicolantonio Andrea Sartore Bianchi Gang Li Salvatore Siena Alberto Bardelli

Cancer Discov 2016 Jan 6;6(1):36-44. Epub 2015 Nov 6.

Department of Oncology, University of Torino, Torino, Italy. Candiolo Cancer Institute, FPO, IRCCS, Torino, Italy.

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January 2016

Assessment of a HER2 scoring system for colorectal cancer: results from a validation study.

Authors:
Emanuele Valtorta Cosimo Martino Andrea Sartore-Bianchi Frédérique Penaullt-Llorca Giuseppe Viale Mauro Risio Massimo Rugge Walter Grigioni Katia Bencardino Sara Lonardi Vittorina Zagonel Francesco Leone Johannes Noe Fortunato Ciardiello Carmine Pinto Roberto Labianca Stefania Mosconi Claudio Graiff Giuseppe Aprile Barbara Frau Carlo Garufi Fotios Loupakis Patrizia Racca Giuseppe Tonini Calogero Lauricella Silvio Veronese Mauro Truini Salvatore Siena Silvia Marsoni Marcello Gambacorta

Mod Pathol 2015 Nov 9;28(11):1481-91. Epub 2015 Oct 9.

Niguarda Cancer Center, Ospedale Niguarda Ca' Granda, Milano, Italy.

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November 2015

The genomic landscape of response to EGFR blockade in colorectal cancer.

Authors:
Andrea Bertotti Eniko Papp Siân Jones Vilmos Adleff Valsamo Anagnostou Barbara Lupo Mark Sausen Jillian Phallen Carolyn A Hruban Collin Tokheim Noushin Niknafs Monica Nesselbush Karli Lytle Francesco Sassi Francesca Cottino Giorgia Migliardi Eugenia R Zanella Dario Ribero Nadia Russolillo Alfredo Mellano Andrea Muratore Gianluca Paraluppi Mauro Salizzoni Silvia Marsoni Michael Kragh Johan Lantto Andrea Cassingena Qing Kay Li Rachel Karchin Robert Scharpf Andrea Sartore-Bianchi Salvatore Siena Luis A Diaz Livio Trusolino Victor E Velculescu

Nature 2015 Oct 30;526(7572):263-7. Epub 2015 Sep 30.

Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA.

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October 2015

Prognostic significance of K-Ras mutation rate in metastatic colorectal cancer patients.

Authors:
Bruno Vincenzi Chiara Cremolini Andrea Sartore-Bianchi Antonio Russo Francesco Mannavola Giuseppe Perrone Francesco Pantano Fotios Loupakis Daniele Rossini Elena Ongaro Erica Bonazzina Emanuela Dell'Aquila Marco Imperatori Alice Zoccoli Giuseppe Bronte Giovanna De Maglio Gabriella Fontanini Clara Natoli Alfredo Falcone Daniele Santini Andrea Onetti-Muda Salvatore Siena Giuseppe Tonini Giuseppe Aprile

Oncotarget 2015 Oct;6(31):31604-12

Department of Medical Oncology, Azienda Ospedaliero-Universitaria, Udine, Italy.

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October 2015

Clonal evolution and resistance to EGFR blockade in the blood of colorectal cancer patients.

Authors:
Giulia Siravegna Benedetta Mussolin Michela Buscarino Giorgio Corti Andrea Cassingena Giovanni Crisafulli Agostino Ponzetti Chiara Cremolini Alessio Amatu Calogero Lauricella Simona Lamba Sebastijan Hobor Antonio Avallone Emanuele Valtorta Giuseppe Rospo Enzo Medico Valentina Motta Carlotta Antoniotti Fabiana Tatangelo Beatriz Bellosillo Silvio Veronese Alfredo Budillon Clara Montagut Patrizia Racca Silvia Marsoni Alfredo Falcone Ryan B Corcoran Federica Di Nicolantonio Fotios Loupakis Salvatore Siena Andrea Sartore-Bianchi Alberto Bardelli

Nat Med 2015 Jul;21(7):827

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July 2015

Effects of Cancer Therapy Targeting Vascular Endothelial Growth Factor Receptor on Central Blood Pressure and Cardiovascular System.

Authors:
Antonella Moreo Paola Vallerio Riccardo Ricotta Miriam Stucchi Mattia Pozzi Francesco Musca Paolo Meani Alessandro Maloberti Rita Facchetti Sara Di Bella Maria Olga Giganti Andrea Sartore-Bianchi Salvatore Siena Giuseppe Mancia Cristina Giannattasio

Am J Hypertens 2016 Feb 1;29(2):158-62. Epub 2015 Jun 1.

Cardiology IV, "A.De Gasperis" Department, Ospedale Niguarda Ca' Granda, Milan, Italy; Health Science Department, Milano-Bicocca University, Milan, Italy;

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February 2016

Clonal evolution and resistance to EGFR blockade in the blood of colorectal cancer patients.

Authors:
Giulia Siravegna Benedetta Mussolin Michela Buscarino Giorgio Corti Andrea Cassingena Giovanni Crisafulli Agostino Ponzetti Chiara Cremolini Alessio Amatu Calogero Lauricella Simona Lamba Sebastijan Hobor Antonio Avallone Emanuele Valtorta Giuseppe Rospo Enzo Medico Valentina Motta Carlotta Antoniotti Fabiana Tatangelo Beatriz Bellosillo Silvio Veronese Alfredo Budillon Clara Montagut Patrizia Racca Silvia Marsoni Alfredo Falcone Ryan B Corcoran Federica Di Nicolantonio Fotios Loupakis Salvatore Siena Andrea Sartore-Bianchi Alberto Bardelli

Nat Med 2015 Jul 1;21(7):795-801. Epub 2015 Jun 1.

1] University of Torino, Department of Oncology, Torino, Italy. [2] Candiolo Cancer Institute - Fondazione Piemontese per l'Oncologia (FPO), Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Candiolo, Torino, Italy.

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July 2015

Germ cell tumors overexpress the candidate therapeutic target cyclin B1 independently of p53 function.

Authors:
Ugo De Giorgi Juping Yuan Mauro Moroni Silvio Veronese Andrea Sartore-Bianchi Massimo Broggini Giovanni Rosti Klaus Strebhardt Pier Adelchi Ruffini

Int J Biol Markers 2015 Jul 22;30(3):e275-81. Epub 2015 Jul 22.

Department of Medical Oncology, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, Meldola (Forlì-Cesena) - Italy.

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July 2015

The molecular landscape of colorectal cancer cell lines unveils clinically actionable kinase targets.

Authors:
Enzo Medico Mariangela Russo Gabriele Picco Carlotta Cancelliere Emanuele Valtorta Giorgio Corti Michela Buscarino Claudio Isella Simona Lamba Barbara Martinoglio Silvio Veronese Salvatore Siena Andrea Sartore-Bianchi Marco Beccuti Marcella Mottolese Michael Linnebacher Francesca Cordero Federica Di Nicolantonio Alberto Bardelli

Nat Commun 2015 Apr 30;6:7002. Epub 2015 Apr 30.

1] Department of Oncology, University of Torino, SP 142, Km 3.95, 10060, Candiolo, Torino, Italy [2] Candiolo Cancer Institute-FPO, IRCCS, 10060, Candiolo (TO), Italy.

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April 2015

Resistance to anti-EGFR therapy in colorectal cancer: from heterogeneity to convergent evolution.

Authors:
Sandra Misale Federica Di Nicolantonio Andrea Sartore-Bianchi Salvatore Siena Alberto Bardelli

Cancer Discov 2014 Nov 7;4(11):1269-80. Epub 2014 Oct 7.

Department of Oncology, University of Torino, Candiolo, Torino, Italy. Candiolo Cancer Institute - FPO, IRCCS, Candiolo, Torino, Italy. FIRC Institute of Molecular Oncology (IFOM), Milano, Italy.

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November 2014

Linitis Plastica of the Rectum As a Clinical Presentation of Metastatic Lobular Carcinoma of the Breast.

Authors:
Filippo Venturini Valentina Gambi Stefano Di Lernia Angelo Vanzulli Manuela Bramerio Katia Bencardino Alessio Amatu Tiziana Cipani Edoardo Forti Emiliana Tarenzi Andrea Sartore-Bianchi Raffaele Pugliese Salvatore Siena

J Clin Oncol 2016 Mar 30;34(7):e54-6. Epub 2014 Jun 30.

Ospedale Niguarda Ca' Granda, Milan, Italy

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March 2016

The TPM3-NTRK1 rearrangement is a recurring event in colorectal carcinoma and is associated with tumor sensitivity to TRKA kinase inhibition.

Authors:
Elena Ardini Roberta Bosotti Andrea Lombardi Borgia Cristina De Ponti Alessio Somaschini Rosaria Cammarota Nadia Amboldi Laura Raddrizzani Andrea Milani Paola Magnaghi Dario Ballinari Daniele Casero Fabio Gasparri Patrizia Banfi Nilla Avanzi Maria B Saccardo Rachele Alzani Tiziano Bandiera Eduard Felder Daniele Donati Enrico Pesenti Andrea Sartore-Bianchi Marcello Gambacorta Marco A Pierotti Salvatore Siena Silvio Veronese Arturo Galvani Antonella Isacchi

Mol Oncol 2014 Dec 12;8(8):1495-507. Epub 2014 Jun 12.

Nerviano Medical Sciences S.r.l., Nerviano (Milan), Italy.

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December 2014

Translational challenges from the 2014 Gastrointestinal Cancers Symposium: toward a true tailored therapy through effective research.

Authors:
Giuseppe Aprile Francesco Giuliani Stefano Cordio Andrea Sartore-Bianchi Katia Bencardino Elena Ongaro Concetta Martines Riccardo Giampieri Roberto Bordonaro Salvatore Siena Stefano Cascinu Mario Scartozzi

Future Oncol 2014 May;10(7):1125-8

Medical Oncology, University & General Hospital, Udine, Italy.

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May 2014

Acquired resistance to EGFR-targeted therapies in colorectal cancer.

Authors:
Beth O Van Emburgh Andrea Sartore-Bianchi Federica Di Nicolantonio Salvatore Siena Alberto Bardelli

Mol Oncol 2014 Sep 14;8(6):1084-94. Epub 2014 May 14.

Candiolo Cancer Institute - FPO, IRCCS, Str prov 142 Km 3.95, 10060 Candiolo, Torino, Italy; University of Torino, Department of Oncology, Strada Provinciale, 142 km 3.95, 10060 Candiolo, Torino, Italy. Electronic address:

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September 2014

Regorafenib in metastatic colorectal cancer.

Authors:
Andrea Sartore-Bianchi Annalisa Zeppellini Alessio Amatu Riccardo Ricotta Katia Bencardino Salvatore Siena

Expert Rev Anticancer Ther 2014 Mar;14(3):255-65

Department of Hematology and Oncology, Niguarda Cancer Center, Ospedale Niguarda Ca' Granda, Milan, Italy.

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March 2014

Blockade of EGFR and MEK intercepts heterogeneous mechanisms of acquired resistance to anti-EGFR therapies in colorectal cancer.

Authors:
Sandra Misale Sabrina Arena Simona Lamba Giulia Siravegna Alice Lallo Sebastijan Hobor Mariangela Russo Michela Buscarino Luca Lazzari Andrea Sartore-Bianchi Katia Bencardino Alessio Amatu Calogero Lauricella Emanuele Valtorta Salvatore Siena Federica Di Nicolantonio Alberto Bardelli

Sci Transl Med 2014 Feb;6(224):224ra26

Department of Oncology, University of Torino, 10060 Candiolo, Torino, Italy.

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February 2014

Detection of circulating tumor DNA in early- and late-stage human malignancies.

Authors:
Chetan Bettegowda Mark Sausen Rebecca J Leary Isaac Kinde Yuxuan Wang Nishant Agrawal Bjarne R Bartlett Hao Wang Brandon Luber Rhoda M Alani Emmanuel S Antonarakis Nilofer S Azad Alberto Bardelli Henry Brem John L Cameron Clarence C Lee Leslie A Fecher Gary L Gallia Peter Gibbs Dung Le Robert L Giuntoli Michael Goggins Michael D Hogarty Matthias Holdhoff Seung-Mo Hong Yuchen Jiao Hartmut H Juhl Jenny J Kim Giulia Siravegna Daniel A Laheru Calogero Lauricella Michael Lim Evan J Lipson Suely Kazue Nagahashi Marie George J Netto Kelly S Oliner Alessandro Olivi Louise Olsson Gregory J Riggins Andrea Sartore-Bianchi Kerstin Schmidt le-Ming Shih Sueli Mieko Oba-Shinjo Salvatore Siena Dan Theodorescu Jeanne Tie Timothy T Harkins Silvio Veronese Tian-Li Wang Jon D Weingart Christopher L Wolfgang Laura D Wood Dongmei Xing Ralph H Hruban Jian Wu Peter J Allen C Max Schmidt Michael A Choti Victor E Velculescu Kenneth W Kinzler Bert Vogelstein Nickolas Papadopoulos Luis A Diaz

Sci Transl Med 2014 Feb;6(224):224ra24

Ludwig Center for Cancer Genetics and Therapeutics, Howard Hughes Medical Institute and the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21231, USA.

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February 2014

Epigenetic inactivation of the BRCA1 interactor SRBC and resistance to oxaliplatin in colorectal cancer.

Authors:
Catia Moutinho Anna Martinez-Cardús Cristina Santos Valentin Navarro-Pérez Eva Martínez-Balibrea Eva Musulen F Javier Carmona Andrea Sartore-Bianchi Andrea Cassingena Salvatore Siena Elena Elez Josep Tabernero Ramon Salazar Albert Abad Manel Esteller

J Natl Cancer Inst 2014 Jan 22;106(1):djt322. Epub 2013 Nov 22.

Affiliations of authors: Cancer Epigenetics and Biology Program, Bellvitge Biomedical Research Institute, Barcelona, Spain (CM, AM-C, FJC, ME); Medical Oncology Service, Catalan Institute of Oncology, Health Sciences Research Institute of the Germans Trias i Pujol Foundation, Barcelona, Spain (AM-C, EM-B, AA); Department of Medical Oncology (CS, RS) and Clinical Informatics Unit (VN-P), Catalan Institute of Oncology, Bellvitge Biomedical Research Institute, L'Hospitalet de Llobregat, Barcelona, Spain; Department of Pathology, Germans Trias i Pujol Foundation, Barcelona, Spain (EM); Department of Hematology and Oncology, Ospedale Niguarda Ca' Granda, Milan, Italy (AS-B, AC, SS); Medical Oncology Department, Vall d'Hebron University Hospital, Barcelona, Spain (EE, JT); Department of Physiological Sciences II, School of Medicine, University of Barcelona, Barcelona, Barcelona, Spain (ME); Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain (ME).

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January 2014

Phase II open-label study to assess efficacy and safety of lenalidomide in combination with cetuximab in KRAS-mutant metastatic colorectal cancer.

Authors:
Salvatore Siena Eric Van Cutsem Mingyu Li Ulf Jungnelius Alfredo Romano Robert Beck Katia Bencardino Maria Elena Elez Hans Prenen Mireia Sanchis Andrea Sartore-Bianchi Sabine Tejpar Anita Gandhi Tao Shi Josep Tabernero

PLoS One 2013 11;8(11):e62264. Epub 2013 Nov 11.

Ospedale Niguarda Ca' Granda, Milan, Italy.

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July 2014

Panitumumab in combination with infusional oxaliplatin and oral capecitabine for conversion therapy in patients with colon cancer and advanced liver metastases. The MetaPan study.

Authors:
Francesco Leone Salvatore Artale Donatella Marino Celeste Cagnazzo Stefano Cascinu Carmine Pinto Giuseppe Fornarini Marco Tampellini Francesca Di Fabio Andrea Sartore-Bianchi Luciano De Carlis Raffaele Pugliese Lorenzo Capussotti Luisa Gioeni Salvatore Siena Massimo Aglietta

Cancer 2013 Oct 18;119(19):3429-35. Epub 2013 Jul 18.

Department of Medical Oncology, Piemonte Oncology Foundation, IRCC-Candiolo, Candiolo, Italy.

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October 2013

Aspirin for colorectal cancer with PIK3CA mutations: the rising of the oldest targeted therapy?

Authors:
Alessio Amatu Katia Bencardino Andrea Sartore-Bianchi Salvatore Siena

Ann Transl Med 2013 Jul;1(2):12

Department of Oncology, Ospedale Niguarda Ca' Granda, Milano, Italy.

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July 2013

Amplification of the MET receptor drives resistance to anti-EGFR therapies in colorectal cancer.

Authors:
Alberto Bardelli Simona Corso Andrea Bertotti Sebastijan Hobor Emanuele Valtorta Giulia Siravegna Andrea Sartore-Bianchi Elisa Scala Andrea Cassingena Davide Zecchin Maria Apicella Giorgia Migliardi Francesco Galimi Calogero Lauricella Carlo Zanon Timothy Perera Silvio Veronese Giorgio Corti Alessio Amatu Marcello Gambacorta Luis A Diaz Mark Sausen Victor E Velculescu Paolo Comoglio Livio Trusolino Federica Di Nicolantonio Silvia Giordano Salvatore Siena

Cancer Discov 2013 Jun 2;3(6):658-73. Epub 2013 Jun 2.

Department of Oncology, University of Torino, Torino, Italy.

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June 2013

Regorafenib for metastatic colorectal cancer.

Authors:
Riccardo Ricotta Andrea Sartore-Bianchi Antonella Verrioli Angelo Vanzulli Salvatore Siena

Lancet 2013 May;381(9877):1537

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May 2013

Promoter CpG island hypermethylation of the DNA repair enzyme MGMT predicts clinical response to dacarbazine in a phase II study for metastatic colorectal cancer.

Authors:
Alessio Amatu Andrea Sartore-Bianchi Catia Moutinho Alessandro Belotti Katia Bencardino Giuseppe Chirico Andrea Cassingena Francesca Rusconi Anna Esposito Michele Nichelatti Manel Esteller Salvatore Siena

Clin Cancer Res 2013 Apr 19;19(8):2265-72. Epub 2013 Feb 19.

Department of Hematology and Oncology, Ospedale Niguarda Ca' Granda, Milan, Italy.

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April 2013

KRAS gene amplification in colorectal cancer and impact on response to EGFR-targeted therapy.

Authors:
Emanuele Valtorta Sandra Misale Andrea Sartore-Bianchi Iris D Nagtegaal François Paraf Calogero Lauricella Valentina Dimartino Sebastijan Hobor Bart Jacobs Cristiana Ercolani Simona Lamba Elisa Scala Silvio Veronese Pierre Laurent-Puig Salvatore Siena Sabine Tejpar Marcella Mottolese Cornelis J A Punt Marcello Gambacorta Alberto Bardelli Federica Di Nicolantonio

Int J Cancer 2013 Sep 16;133(5):1259-65. Epub 2013 Mar 16.

Division of Pathology, Ospedale Niguarda Ca' Granda, Piazza Ospedale Maggiore 3, Milano, Italy.

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September 2013

Magnetic resonance imaging as an early indicator of clinical outcome in patients with metastatic colorectal carcinoma treated with cetuximab or panitumumab.

Authors:
Riccardo Ricotta Angelo Vanzulli Mauro Moroni Barbara Colnago Matteo Oriani Michele Nichelatti Carolina Sarnataro Filippo Venturini Sara Di Bella Martina Maiolani Maria Olga Giganti Andrea Sartore-Bianchi Salvatore Siena

Clin Colorectal Cancer 2013 Mar 4;12(1):45-53. Epub 2012 Oct 4.

The Falck Division of Oncology, Ospedale Niguarda Ca' Granda, Milan, Italy.

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March 2013

New frontiers in therapeutic resistance in cancer.

Authors:
Andrea Sartore-Bianchi Mauro Delorenzi Thérèse Gagnon-Kugler Caroline Rousseau Gerald Batist

Expert Rev Anticancer Ther 2012 Jul;12(7):877-9

Falck Division of Medical Oncology, Department of Oncology, Ospedale Niguarda Ca' Granda, Piazza Ospedale Maggiore, 3 20162 Milano, Italy.

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July 2012

Emergence of KRAS mutations and acquired resistance to anti-EGFR therapy in colorectal cancer.

Authors:
Sandra Misale Rona Yaeger Sebastijan Hobor Elisa Scala Manickam Janakiraman David Liska Emanuele Valtorta Roberta Schiavo Michela Buscarino Giulia Siravegna Katia Bencardino Andrea Cercek Chin-Tung Chen Silvio Veronese Carlo Zanon Andrea Sartore-Bianchi Marcello Gambacorta Margherita Gallicchio Efsevia Vakiani Valentina Boscaro Enzo Medico Martin Weiser Salvatore Siena Federica Di Nicolantonio David Solit Alberto Bardelli

Nature 2012 Jun;486(7404):532-6

Laboratory of Molecular Genetics, Institute for Cancer Research and Treatment, 10060 Candiolo (Torino), Italy.

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June 2012

A molecularly annotated platform of patient-derived xenografts ("xenopatients") identifies HER2 as an effective therapeutic target in cetuximab-resistant colorectal cancer.

Authors:
Andrea Bertotti Giorgia Migliardi Francesco Galimi Francesco Sassi Davide Torti Claudio Isella Davide Corà Federica Di Nicolantonio Michela Buscarino Consalvo Petti Dario Ribero Nadia Russolillo Andrea Muratore Paolo Massucco Alberto Pisacane Luca Molinaro Emanuele Valtorta Andrea Sartore-Bianchi Mauro Risio Lorenzo Capussotti Marcello Gambacorta Salvatore Siena Enzo Medico Anna Sapino Silvia Marsoni Paolo M Comoglio Alberto Bardelli Livio Trusolino

Cancer Discov 2011 Nov 2;1(6):508-23. Epub 2011 Sep 2.

Laboratory of Molecular Pharmacology, Division of Surgical Oncology, Unit of Pathology, Institute for Cancer Research and Treatment, Torino, Italy.

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November 2011

Standardisation of EGFR FISH in colorectal cancer: results of an international interlaboratory reproducibility ring study.

Authors:
Andrea Sartore-Bianchi Steffen Fieuws Silvio Veronese Mauro Moroni Nicola Personeni Milo Frattini Valter Torri Federico Cappuzzo Sara Vander Borght Vittoria Martin Margaret Skokan Armando Santoro Marcello Gambacorta Sabine Tejpar Marileila Varella-Garcia Salvatore Siena

J Clin Pathol 2012 Mar 30;65(3):218-23. Epub 2011 Nov 30.

The FalcK Division Of Medical Oncology, Ospedale Niguarda Ca' Granda, Milan, Italy.

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March 2012

Association of KRAS p.G13D mutation with outcome in patients with chemotherapy-refractory metastatic colorectal cancer treated with cetuximab.

Authors:
Wendy De Roock Derek J Jonker Federica Di Nicolantonio Andrea Sartore-Bianchi Dongsheng Tu Salvatore Siena Simona Lamba Sabrina Arena Milo Frattini Hubert Piessevaux Eric Van Cutsem Chris J O'Callaghan Shirin Khambata-Ford John R Zalcberg John Simes Christos S Karapetis Alberto Bardelli Sabine Tejpar

JAMA 2010 Oct;304(16):1812-20

Center for Human Genetics, University of Leuven, Leuven, Belgium.

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October 2010

Effects of KRAS, BRAF, NRAS, and PIK3CA mutations on the efficacy of cetuximab plus chemotherapy in chemotherapy-refractory metastatic colorectal cancer: a retrospective consortium analysis.

Authors:
Wendy De Roock Bart Claes David Bernasconi Jef De Schutter Bart Biesmans George Fountzilas Konstantine T Kalogeras Vassiliki Kotoula Demetris Papamichael Pierre Laurent-Puig Frédérique Penault-Llorca Philippe Rougier Bruno Vincenzi Daniele Santini Giuseppe Tonini Federico Cappuzzo Milo Frattini Francesca Molinari Piercarlo Saletti Sara De Dosso Miriam Martini Alberto Bardelli Salvatore Siena Andrea Sartore-Bianchi Josep Tabernero Teresa Macarulla Frédéric Di Fiore Alice Oden Gangloff Fortunato Ciardiello Per Pfeiffer Camilla Qvortrup Tine Plato Hansen Eric Van Cutsem Hubert Piessevaux Diether Lambrechts Mauro Delorenzi Sabine Tejpar

Lancet Oncol 2010 Aug 8;11(8):753-62. Epub 2010 Jul 8.

Centre for Human Genetics, KU Leuven, Leuven, Belgium.

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August 2010

Integrated molecular dissection of the epidermal growth factor receptor (EGFR) [corrected] oncogenic pathway to predict response to EGFR-targeted monoclonal antibodies in metastatic colorectal cancer.

Authors:
Andrea Sartore-Bianchi Katia Bencardino Federica Di Nicolantonio Federico Pozzi Chiara Funaioli Valentina Gambi Sabrina Arena Miriam Martini Simona Lamba Andrea Cassingena Roberta Schiavo Alberto Bardelli Salvatore Siena

Target Oncol 2010 Mar 11;5(1):19-28. Epub 2010 Apr 11.

The Falck Division of Medical Oncology, Ospedale Niguarda Ca' Granda, Milan, Italy.

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March 2010

Multi-determinants analysis of molecular alterations for predicting clinical benefit to EGFR-targeted monoclonal antibodies in colorectal cancer.

Authors:
Andrea Sartore-Bianchi Federica Di Nicolantonio Michele Nichelatti Francesca Molinari Sara De Dosso Piercarlo Saletti Miriam Martini Tiziana Cipani Giovanna Marrapese Luca Mazzucchelli Simona Lamba Silvio Veronese Milo Frattini Alberto Bardelli Salvatore Siena

PLoS One 2009 Oct 2;4(10):e7287. Epub 2009 Oct 2.

The Falck Division of Medical Oncology, Ospedale Niguarda Ca' Granda, Milan, Italy.

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October 2009

Biomarkers predicting clinical outcome of epidermal growth factor receptor-targeted therapy in metastatic colorectal cancer.

Authors:
Salvatore Siena Andrea Sartore-Bianchi Federica Di Nicolantonio Julia Balfour Alberto Bardelli

J Natl Cancer Inst 2009 Oct 8;101(19):1308-24. Epub 2009 Sep 8.

The Falck Division of Medical Oncology, Ospedale Niguarda Ca' Granda, Piazza Ospedale Maggiore 3, 20162 Milan, Italy.

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October 2009

PIK3CA mutations in colorectal cancer are associated with clinical resistance to EGFR-targeted monoclonal antibodies.

Authors:
Andrea Sartore-Bianchi Miriam Martini Francesca Molinari Silvio Veronese Michele Nichelatti Salvatore Artale Federica Di Nicolantonio Piercarlo Saletti Sara De Dosso Luca Mazzucchelli Milo Frattini Salvatore Siena Alberto Bardelli

Cancer Res 2009 Mar 17;69(5):1851-7. Epub 2009 Feb 17.

The Falck Division of Medical Oncology, Ospedale Niguarda Ca' Granda, Milan, Italy.

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March 2009

Wild-type BRAF is required for response to panitumumab or cetuximab in metastatic colorectal cancer.

Authors:
Federica Di Nicolantonio Miriam Martini Francesca Molinari Andrea Sartore-Bianchi Sabrina Arena Piercarlo Saletti Sara De Dosso Luca Mazzucchelli Milo Frattini Salvatore Siena Alberto Bardelli

J Clin Oncol 2008 Dec 10;26(35):5705-12. Epub 2008 Nov 10.

Laboratory of Molecular Genetics, The Oncogenomics Center, Institute for Cancer Research and Treatment, University of Torino, Medical School, Candiolo, Torino, Italy.

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December 2008

Mutations of KRAS and BRAF in primary and matched metastatic sites of colorectal cancer.

Authors:
Salvatore Artale Andrea Sartore-Bianchi Silvio Marco Veronese Valentina Gambi Carolina Silvia Sarnataro Marcello Gambacorta Calogero Lauricella Salvatore Siena

J Clin Oncol 2008 Sep;26(25):4217-9

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September 2008

EGFR FISH in colorectal cancer: what is the current reality?

Authors:
Mauro Moroni Andrea Sartore-Bianchi Silvio Veronese Salvatore Siena

Lancet Oncol 2008 May;9(5):402-3

Falck Division of Medical Oncology, Niguarda Ca' Granda Hospital, 20162 Milan, Italy.

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May 2008

Bortezomib inhibits nuclear factor-kappaB dependent survival and has potent in vivo activity in mesothelioma.

Authors:
Andrea Sartore-Bianchi Fabio Gasparri Arturo Galvani Linda Nici James W Darnowski Dario Barbone Dean A Fennell Giovanni Gaudino Camillo Porta Luciano Mutti

Clin Cancer Res 2007 Oct;13(19):5942-51

Institute of Internal Medicine and Medical Oncology, IRCCS Policlinico San Matteo University Hospital, 1-27100 Pavia [corrected] Italy.

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October 2007

Epidermal growth factor receptor gene copy number and clinical outcome of metastatic colorectal cancer treated with panitumumab.

Authors:
Andrea Sartore-Bianchi Mauro Moroni Silvio Veronese Carlo Carnaghi Emilio Bajetta Gabriele Luppi Alberto Sobrero Carlo Barone Stefano Cascinu Giuseppe Colucci Enrico Cortesi Michele Nichelatti Marcello Gambacorta Salvatore Siena

J Clin Oncol 2007 Aug;25(22):3238-45

Divisione Oncologia Falck, Ospedale Niguarda Ca' Granda, Piazza Ospedale Maggiore 3, 20162 Milan, Italy.

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August 2007