Andrea Sacconi

YAP/TAZ and EZH2 synergize to impair tumor suppressor activity of TGFBR2 in non-small cell lung cancer.

Authors:

Federica Lo Sardo Claudio Pulito Andrea Sacconi Etleva Korita Marius Sudol Sabrina Strano Giovanni Blandino

Cancer Lett 2021 Mar 6;500:51-63. Epub 2020 Dec 6.

UOSD Oncogenomic and Epigenetic Unit, IRCCS Regina Elena National Cancer Institute, Rome, Italy. Electronic address:

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March 2021

Aberrant transcriptional and post-transcriptional regulation of SPAG5, a YAP-TAZ-TEAD downstream effector, fuels breast cancer cell proliferation.

Authors:

Valeria Canu Sara Donzelli Andrea Sacconi Federica Lo Sardo Claudio Pulito Noa Bossel Anna Di Benedetto Paola Muti Claudio Botti Eytan Domany Silvio Bicciato Sabrina Strano Yosef Yarden Giovanni Blandino

Cell Death Differ 2020 Nov 23. Epub 2020 Nov 23.

Oncogenomic and Epigenetic Unit, Department of Research, Diagnosis and Innovative Technologies, IRCCS Regina Elena National Cancer Institute, Rome, Italy.

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November 2020

Targeting endothelin 1 receptor-miR-200b/c-ZEB1 circuitry blunts metastatic progression in ovarian cancer.

Authors:

Rosanna Sestito Roberta Cianfrocca Piera Tocci Laura Rosanò Andrea Sacconi Giovanni Blandino Anna Bagnato

Commun Biol 2020 Nov 13;3(1):677. Epub 2020 Nov 13.

Preclinical Models and New Therapeutic Agents Unit, IRCCS-Regina Elena National Cancer Institute, Rome, Italy.

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November 2020

LINC00174 is a novel prognostic factor in thymic epithelial tumors involved in cell migration and lipid metabolism.

Cell Death Dis 2020 11 7;11(11):959. Epub 2020 Nov 7.

Department of Anatomical, Histological, Forensic & Orthopedic Sciences, Section of Histology & Medical Embryology, Sapienza University of Rome, Laboratory Affiliated to Istituto Pasteur Italia-Fondazione Cenci Bolognetti, Rome, Italy.

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November 2020

The RNA-binding protein MEX3A is a prognostic factor and regulator of resistance to gemcitabine in pancreatic ductal adenocarcinoma.

Authors:

Valentina Panzeri Isabella Manni Alessia Capone Chiara Naro Andrea Sacconi Silvia Di Agostino Luisa de Latouliere Andrea Montori Emanuela Pilozzi Giulia Piaggio Gabriele Capurso Claudio Sette

Mol Oncol 2020 Nov 7. Epub 2020 Nov 7.

Department of Neuroscience, Section of Human Anatomy, Catholic University of the Sacred Heart, Rome, Italy.

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November 2020

Effects of a Small Increase in Carbon Dioxide Pressure during Fermentation on Wine Aroma.

Authors:

Lorenzo Guerrini Piernicola Masella Giulia Angeloni Andrea Sacconi Luca Calamai Alessandro Parenti

Foods 2020 Oct 19;9(10). Epub 2020 Oct 19.

Dipartimento di Scienze e Tecnologie Agrarie, Alimentari, Ambientali e Forestali, Università degli Studi di Firenze, Piazzale delle Cascine 16, 50144 Firenze, Italy.

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October 2020

TMPRSS2, a SARS-CoV-2 internalization protease is downregulated in head and neck cancer patients.

Authors:

Andrea Sacconi Sara Donzelli Claudio Pulito Stefano Ferrero Francesca Spinella Aldo Morrone Marta Rigoni Fulvia Pimpinelli Fabrizio Ensoli Giuseppe Sanguineti Raul Pellini Nishant Agrawal Evgeny Izumchenko Gennaro Ciliberto Aldo Giannì Paola Muti Sabrina Strano Giovanni Blandino

J Exp Clin Cancer Res 2020 Sep 23;39(1):200. Epub 2020 Sep 23.

UOSD Clinical Trial Center, Biostatistics and Bioinformatics, IRCCS Regina Elena National Cancer Institute, Rome, Italy.

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September 2020

Loss of Two-Pore Channel 2 (TPC2) Expression Increases the Metastatic Traits of Melanoma Cells by a Mechanism Involving the Hippo Signalling Pathway and Store-Operated Calcium Entry.

Authors:

Antonella D'Amore Ali Ahmed Hanbashi Silvia Di Agostino Fioretta Palombi Andrea Sacconi Aniruddha Voruganti Marilena Taggi Rita Canipari Giovanni Blandino John Parrington Antonio Filippini

Cancers (Basel) 2020 Aug 24;12(9). Epub 2020 Aug 24.

Department of Anatomy, Histology, Forensic Medicine and Orthopaedics, Unit of Histology and Medical Embryology, SAPIENZA University of Rome, 16 Via A. Scarpa, 00161 Roma, Italy.

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August 2020

TRF2 and VEGF-A: an unknown relationship with prognostic impact on survival of colorectal cancer patients.

Authors:

Roberto Dinami Manuela Porru Carla Azzurra Amoreo Isabella Sperduti Marcella Mottolese Simonetta Buglioni Daniele Marinelli Marcello Maugeri-Saccà Andrea Sacconi Giovanni Blandino Carlo Leonetti Giuliana Di Rocco Alessandra Verdina Francesca Spinella Francesco Fiorentino Gennaro Ciliberto Annamaria Biroccio Pasquale Zizza

J Exp Clin Cancer Res 2020 Jun 15;39(1):111. Epub 2020 Jun 15.

Oncogenomic and Epigenetic Unit, IRCCS - Regina Elena National Cancer Institute, Via Elio Chianesi 53, 00144, Rome, Italy.

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June 2020

Non-coding RNAs as Putative Biomarkers of Cancer-Associated Cachexia.

Authors:

Sara Donzelli Alessia Farneti Laura Marucci Federica Ganci Andrea Sacconi Sabrina Strano Giuseppe Sanguineti Giovanni Blandino

Front Cell Dev Biol 2020 21;8:257. Epub 2020 Apr 21.

Oncogenomic and Epigenetic Unit, IRCCS Regina Elena National Cancer Institute, Rome, Italy.

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April 2020

microRNA-378a-5p iS a novel positive regulator of melanoma progression.

Authors:

Maria Grazia Tupone Simona D'Aguanno Marta Di Martile Elisabetta Valentini Marianna Desideri Daniela Trisciuoglio Sara Donzelli Andrea Sacconi Simonetta Buglioni Cristiana Ercolani Alessio Biagioni Gabriella Fibbi Luigi Fattore Rita Mancini Gennaro Ciliberto Giovanni Blandino Donatella Del Bufalo

Oncogenesis 2020 Feb 14;9(2):22. Epub 2020 Feb 14.

Preclinical Models and New Therapeutic Agents Unit, IRCCS Regina Elena National Cancer Institute, Rome, Italy.

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February 2020

Paracrine Signaling from Breast Cancer Cells Causes Activation of ID4 Expression in Tumor-Associated Macrophages.

Authors:

Sara Donzelli Andrea Sacconi Chiara Turco Enzo Gallo Elisa Milano Ilaria Iosue Giovanni Blandino Francesco Fazi Giulia Fontemaggi

Cells 2020 02 11;9(2). Epub 2020 Feb 11.

IRCCS Regina Elena National Cancer Institute, Oncogenomic and Epigenetic Unit, Via E. Chianesi, 53, 00144 Rome, Italy.

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February 2020

PI3K Inhibitors Curtail MYC-Dependent Mutant p53 Gain-of-Function in Head and Neck Squamous Cell Carcinoma.

Clin Cancer Res 2020 06 22;26(12):2956-2971. Epub 2020 Jan 22.

Oncogenomic and Epigenetic Unit, IRCCS Regina Elena National Cancer Institute, Rome, Italy.

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June 2020

The miR-205-5p/BRCA1/RAD17 Axis Promotes Genomic Instability in Head and Neck Squamous Cell Carcinomas.

Authors:

Fabio Valenti Andrea Sacconi Federica Ganci Giuseppe Grasso Sabrina Strano Giovanni Blandino Silvia Di Agostino

Cancers (Basel) 2019 09 11;11(9). Epub 2019 Sep 11.

Oncogenomic and Epigenetic Unit, Department of Diagnostic Research and Technological Innovation, IRCCS Regina Elena National Cancer Institute, 00144 Rome, Italy.

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September 2019

Dropwort-induced metabolic reprogramming restrains YAP/TAZ/TEAD oncogenic axis in mesothelioma.

Authors:

Claudio Pulito Etleva Korita Andrea Sacconi Mariacristina Valerio Luca Casadei Federica Lo Sardo Federica Mori Maria Ferraiuolo Giuseppe Grasso Anna Maidecchi Jacopo Lucci Marius Sudol Paola Muti Giovanni Blandino Sabrina Strano

J Exp Clin Cancer Res 2019 Aug 9;38(1):349. Epub 2019 Aug 9.

Oncogenomic and Epigenetic Unit, Department of Research, Diagnosis and Innovative Technologies, IRCCS Regina Elena National Cancer Institute, Via Elio Chianesi, 53, 00144, Rome, Italy.

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August 2019

β-arrestin1/YAP/mutant p53 complexes orchestrate the endothelin A receptor signaling in high-grade serous ovarian cancer.

Authors:

Piera Tocci Roberta Cianfrocca Valeriana Di Castro Laura Rosanò Andrea Sacconi Sara Donzelli Silvia Bonfiglio Gabriele Bucci Enrico Vizza Gabriella Ferrandina Giovanni Scambia Giovanni Tonon Giovanni Blandino Anna Bagnato

Nat Commun 2019 07 19;10(1):3196. Epub 2019 Jul 19.

Preclinical Models and New Therapeutic Agents Unit, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Regina Elena National Cancer Institute, 00144, Rome, Italy.

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July 2019

Wild type- and mutant p53 proteins in mitochondrial dysfunction: emerging insights in cancer disease.

Authors:

Giovanni Blandino Fabio Valenti Andrea Sacconi Silvia Di Agostino

Semin Cell Dev Biol 2020 02 23;98:105-117. Epub 2019 May 23.

Oncogenomic and Epigenetic Unit, Department of Diagnostic Research and Technological Innovation, IRCCS Regina Elena National Cancer Institute, Rome, 00144, Italy. Electronic address:

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February 2020

May predictors of difficulty in thyroid surgery increase the incidence of complications? Prospective study with the proposal of a preoperative score.

Authors:

Valerio D'Orazi Andrea Sacconi Silvia Trombetta Menelaos Karpathiotakis Daniele Pichelli Enrico Di Lorenzo Alice Ortensi Paolo Urciuoli Marco Biffoni Andrea Ortensi

BMC Surg 2019 Apr 24;18(Suppl 1):116. Epub 2019 Apr 24.

Department of General Microsurgery and Hand Surgery, "Fabia Mater" Hospital, Rome, Italy.

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April 2019

miR-96-5p targets PTEN expression affecting radio-chemosensitivity of HNSCC cells.

Authors:

Mahrou Vahabi Claudio Pulito Andrea Sacconi Sara Donzelli Marco D'Andrea Valentina Manciocco Raul Pellini Paola Paci Giuseppe Sanguineti Lidia Strigari Giuseppe Spriano Paola Muti Pier Paolo Pandolfi Sabrina Strano Shahrokh Safarian Federica Ganci Giovanni Blandino

J Exp Clin Cancer Res 2019 Mar 29;38(1):141. Epub 2019 Mar 29.

Oncogenomics and Epigenetics Unit, IRCCS-Regina Elena National Cancer Institute, 00144, Rome, Italy.

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March 2019

TRF2 positively regulates SULF2 expression increasing VEGF-A release and activity in tumor microenvironment.

Nucleic Acids Res 2019 04;47(7):3365-3382

Oncogenomic and Epigenetic Unit, IRCCS - Regina Elena National Cancer Institute, Via Elio Chianesi 53, Rome 00144, Italy.

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April 2019

Argonaute 2 drives miR-145-5p-dependent gene expression program in breast cancer cells.

Authors:

Teresa Bellissimo Claudia Tito Federica Ganci Andrea Sacconi Silvia Masciarelli Giuseppe Di Martino Natale Porta Mirko Cirenza Melissa Sorci Luciana De Angelis Paolo Rosa Antonella Calogero Alessandro Fatica Vincenzo Petrozza Giulia Fontemaggi Giovanni Blandino Francesco Fazi

Cell Death Dis 2019 01 8;10(1):17. Epub 2019 Jan 8.

Department of Anatomical, Histological, Forensic & Orthopedic Sciences, Section of Histology & Medical Embryology, Sapienza University of Rome, laboratory affiliated to Istituto Pasteur Italia-Fondazione Cenci Bolognetti, Rome, Italy.

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January 2019

Targeting a phospho-STAT3-miRNAs pathway improves vesicular hepatic steatosis in an in vitro and in vivo model.

Authors:

Laura Belloni Silvia Di Cocco Francesca Guerrieri Abigail D G Nunn Silvia Piconese Debora Salerno Barbara Testoni Claudio Pulito Federica Mori Matteo Pallocca Andrea Sacconi Elisa Vivoli Fabio Marra Sabrina Strano Giovanni Blandino Massimo Levrero Natalia Pediconi

Sci Rep 2018 09 11;8(1):13638. Epub 2018 Sep 11.

Center for Life Nano Science@Sapienza, Istituto Italiano di Tecnologia, Rome, Italy.

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September 2018

Transcriptional activation of the miR-17-92 cluster is involved in the growth-promoting effects of MYB in human Ph-positive leukemia cells.

Authors:

Manuela Spagnuolo Giulia Regazzo Marco De Dominici Andrea Sacconi Andrea Pelosi Etleva Korita Francesco Marchesi Francesco Pisani Alessandra Magenta Valentina Lulli Iole Cordone Andrea Mengarelli Sabrina Strano Giovanni Blandino Maria G Rizzo Bruno Calabretta

Haematologica 2019 01 3;104(1):82-92. Epub 2018 Aug 3.

Department of Cancer Biology and Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, USA

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January 2019

Expression of ID4 protein in breast cancer cells induces reprogramming of tumour-associated macrophages.

Authors:

Sara Donzelli Elisa Milano Magdalena Pruszko Andrea Sacconi Silvia Masciarelli Ilaria Iosue Elisa Melucci Enzo Gallo Irene Terrenato Marcella Mottolese Maciej Zylicz Alicja Zylicz Francesco Fazi Giovanni Blandino Giulia Fontemaggi

Breast Cancer Res 2018 06 19;20(1):59. Epub 2018 Jun 19.

Oncogenomics and Epigenetics Unit, IRCCS Regina Elena National Cancer Institute, Via Elio Chianesi 53, 00144, Rome, Italy.

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June 2018

Serum miR-22 as potential non-invasive predictor of poor clinical outcome in newly diagnosed, uniformly treated patients with diffuse large B-cell lymphoma: an explorative pilot study.

Authors:

Francesco Marchesi Giulia Regazzo Francesca Palombi Irene Terrenato Andrea Sacconi Manuela Spagnuolo Sara Donzelli Mirella Marino Cristiana Ercolani Anna Di Benedetto Giovanni Blandino Gennaro Ciliberto Andrea Mengarelli Maria Giulia Rizzo

J Exp Clin Cancer Res 2018 May 2;37(1):95. Epub 2018 May 2.

Department of Research, Advanced Diagnostics and Technological Innovation, Genomic and Epigenetic Unit, Translational Research Area, IRCCS Regina Elena National Cancer Institute, Via Elio Chianesi 53, 00144, Rome, Italy.

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May 2018

Long Non-coding MIR205HG Depletes Hsa-miR-590-3p Leading to Unrestrained Proliferation in Head and Neck Squamous Cell Carcinoma.

Authors:

Silvia Di Agostino Fabio Valenti Andrea Sacconi Giulia Fontemaggi Matteo Pallocca Claudio Pulito Federica Ganci Paola Muti Sabrina Strano Giovanni Blandino

Theranostics 2018 12;8(7):1850-1868. Epub 2018 Feb 12.

Oncogenomic and Epigenetic Unit, Department of Diagnostic Research and Technological Innovation, IRCCS Regina Elena National Cancer Institute, Rome 00144, Italy.

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February 2019

hMENA is a key regulator in endothelin-1/β-arrestin1-induced invadopodial function and metastatic process.

Authors:

Francesca Di Modugno Valentina Caprara Lidia Chellini Piera Tocci Francesca Spadaro Gabriella Ferrandina Andrea Sacconi Giovanni Blandino Paola Nisticò Anna Bagnato Laura Rosanò

Proc Natl Acad Sci U S A 2018 03 8;115(12):3132-3137. Epub 2018 Feb 8.

Unit of Preclinical Models and New Therapeutic Agents, IRCCS, Regina Elena National Cancer Institute, 00144 Rome, Italy;

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March 2018

The oncogenic role of circPVT1 in head and neck squamous cell carcinoma is mediated through the mutant p53/YAP/TEAD transcription-competent complex.

Authors:

Lorena Verduci Maria Ferraiuolo Andrea Sacconi Federica Ganci Jlenia Vitale Teresa Colombo Paola Paci Sabrina Strano Giuseppe Macino Nikolaus Rajewsky Giovanni Blandino

Genome Biol 2017 Dec 20;18(1):237. Epub 2017 Dec 20.

Oncogenomic and Epigenetic Unit, Italian National Cancer Institute, "Regina Elena", 00144, Rome, Italy.

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December 2017

MicroRNA-128-3p-mediated depletion of Drosha promotes lung cancer cell migration.

Authors:

Tania Frixa Andrea Sacconi Mario Cioce Giuseppe Roscilli Fabiana Fosca Ferrara Luigi Aurisicchio Claudio Pulito Stefano Telera Mariantonia Carosi Paola Muti Sabrina Strano Sara Donzelli Giovanni Blandino

Carcinogenesis 2018 02;39(2):293-304

Oncogenomic and Epigenetic Unit, Italian National Cancer Institute 'Regina Elena', Rome, Italy.

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February 2018

Epigenetic silencing of miR-296 and miR-512 ensures hTERT dependent apoptosis protection and telomere maintenance in basal-type breast cancer cells.

Authors:

Roberto Dinami Valentina Buemi Rosanna Sestito Antonina Zappone Yari Ciani Miguel Mano Eleonora Petti Andrea Sacconi Giovanni Blandino Mauro Giacca Silvano Piazza Roberta Benetti Stefan Schoeftner

Oncotarget 2017 Nov 23;8(56):95674-95691. Epub 2017 Sep 23.

Laboratorio Nazionale Consorzio Interuniversitario Biotecnologie (LNCIB), Genomic Stability Unit, Trieste 34149, Italy.

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November 2017

MiRNA-513a-5p inhibits progesterone receptor expression and constitutes a risk factor for breast cancer: the hOrmone and Diet in the ETiology of breast cancer prospective study.

Authors:

Paola Muti Sara Donzelli Andrea Sacconi Ahmed Hossain Federica Ganci Tania Frixa Sabina Sieri Vittorio Krogh Franco Berrino Francesca Biagioni Sabrina Strano Joseph Beyene Yosef Yarden Giovanni Blandino

Carcinogenesis 2018 02;39(2):98-108

Department of Oncology, Faculty of Health Science, McMaster University, Hamilton, ON, Canada.

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February 2018

Altered peritumoral microRNA expression predicts head and neck cancer patients with a high risk of recurrence.

Authors:

Federica Ganci Andrea Sacconi Valentina Manciocco Renato Covello Maria Benevolo Francesca Rollo Sabrina Strano Sara Valsoni Silvio Bicciato Giuseppe Spriano Paola Muti Giulia Fontemaggi Giovanni Blandino

Mod Pathol 2017 10 21;30(10):1387-1401. Epub 2017 Jul 21.

Oncogenomic and Epigenetic Unit, Italian National Cancer Institute 'Regina Elena', Rome, Italy.

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October 2017

Metformin-induced ablation of microRNA 21-5p releases Sestrin-1 and CAB39L antitumoral activities.

Authors:

Claudio Pulito Federica Mori Andrea Sacconi Frauke Goeman Maria Ferraiuolo Patrizia Pasanisi Carlo Campagnoli Franco Berrino Maurizio Fanciulli Rebecca J Ford Massimo Levrero Natalia Pediconi Ludovica Ciuffreda Michele Milella Gregory R Steinberg Mario Cioce Paola Muti Sabrina Strano Giovanni Blandino

Cell Discov 2017 4;3:17022. Epub 2017 Jul 4.

Oncogenomic and Epigenetic Unit, Italian National Cancer Institute 'Regina Elena', Rome, Italy.

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July 2017

In vitro antineoplastic effects of brivaracetam and lacosamide on human glioma cells.

Authors:

Ambra Rizzo Sara Donzelli Vita Girgenti Andrea Sacconi Chiara Vasco Andrea Salmaggi Giovanni Blandino Marta Maschio Emilio Ciusani

J Exp Clin Cancer Res 2017 06 6;36(1):76. Epub 2017 Jun 6.

Laboratory of Clinical Pathology and Medical Genetics, Foundation IRCCS Neurological Institute C. Besta, Via Celoria, 11, 20133, Milan, Italy.

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June 2017

MicroRNA-driven deregulation of cytokine expression helps development of drug resistance in metastatic melanoma.

Authors:

Luigi Fattore Andrea Sacconi Rita Mancini Gennaro Ciliberto

Cytokine Growth Factor Rev 2017 08 17;36:39-48. Epub 2017 May 17.

Regina Elena National Cancer Institute, Rome, Italy. Electronic address:

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August 2017

AMPK β1 reduces tumor progression and improves survival in p53 null mice.

Authors:

Vanessa P Houde Sara Donzelli Andrea Sacconi Sandra Galic Joanne A Hammill Jonathan L Bramson Robert A Foster Theodoros Tsakiridis Bruce E Kemp Giuseppe Grasso Giovanni Blandino Paola Muti Gregory R Steinberg

Mol Oncol 2017 09 28;11(9):1143-1155. Epub 2017 Jun 28.

Department of Medicine, McMaster University, Hamilton, Canada.

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September 2017

Thymic Epithelial Tumors phenotype relies on miR-145-5p epigenetic regulation.

Authors:

Teresa Bellissimo Federica Ganci Enzo Gallo Andrea Sacconi Claudia Tito Luciana De Angelis Claudio Pulito Silvia Masciarelli Daniele Diso Marco Anile Vincenzo Petrozza Felice Giangaspero Edoardo Pescarmona Francesco Facciolo Federico Venuta Mirella Marino Giovanni Blandino Francesco Fazi

Mol Cancer 2017 05 10;16(1):88. Epub 2017 May 10.

Deptartment of Anatomical, Histological, Forensic & Orthopaedic Sciences, Section of Histology & Medical Embryology, Sapienza University of Rome, Rome, Italy.

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May 2017

PTEN status is a crucial determinant of the functional outcome of combined MEK and mTOR inhibition in cancer.

Sci Rep 2017 02 21;7:43013. Epub 2017 Feb 21.

Medical Oncology 1, Regina Elena National Cancer Institute, Rome, Italy.

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February 2017

MiR-204 down-regulation elicited perturbation of a gene target signature common to human cholangiocarcinoma and gastric cancer.

Authors:

Valeria Canu Andrea Sacconi Laura Lorenzon Francesca Biagioni Federica Lo Sardo Maria Grazia Diodoro Paola Muti Alfredo Garofalo Sabrina Strano Antonietta D'Errico Gian Luca Grazi Mario Cioce Giovanni Blandino

Oncotarget 2017 May;8(18):29540-29557

Oncogenomic and Epigenetic Unit, Italian National Cancer Institute 'Regina Elena', Rome, Italy.

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May 2017

MCM7 and its hosted miR-25, 93 and 106b cluster elicit YAP/TAZ oncogenic activity in lung cancer.

Authors:

Federica Lo Sardo Mattia Forcato Andrea Sacconi Valeria Capaci Francesca Zanconato Silvia Di Agostino Giannino Del Sal Pier Paolo Pandolfi Sabrina Strano Silvio Bicciato Giovanni Blandino

Carcinogenesis 2017 01 17;38(1):64-75. Epub 2016 Oct 17.

Department of Life Sciences, Center for Genome Research, University of Modena and Reggio Emilia, via G. Campi 287, 41100 Modena, Italy.

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January 2017

Reduction of estradiol in human malignant pleural mesothelioma tissues may prevent tumour growth, as implied by in in-vivo and in-vitro models.

Authors:

Barbara Nuvoli Andrea Sacconi Giancarlo Cortese Sabrina Germoni Bruno Murer Rossella Galati

Oncotarget 2016 Jul;7(30):47116-47126

Preclinical Models and New Therapeutic Agent Unit, Regina Elena National Cancer Institute, Rome, Italy.

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July 2016

Multitargeting activity of miR-24 inhibits long-term melatonin anticancer effects.

Authors:

Federica Mori Maria Ferraiuolo Raffaela Santoro Andrea Sacconi Frauke Goeman Matteo Pallocca Claudio Pulito Etleva Korita Maurizio Fanciulli Paola Muti Giovanni Blandino Sabrina Strano

Oncotarget 2016 Apr;7(15):20532-48

Molecular Chemoprevention Unit, Molecular Medicine Area, Regina Elena National Cancer Institute, 00144 Rome, Italy.

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April 2016

miR-30a inhibits endothelin A receptor and chemoresistance in ovarian carcinoma.

Authors:

Rosanna Sestito Roberta Cianfrocca Laura Rosanò Piera Tocci Elisa Semprucci Valeriana Di Castro Valentina Caprara Gabriella Ferrandina Andrea Sacconi Giovanni Blandino Anna Bagnato

Oncotarget 2016 Jan;7(4):4009-23

Translational Research Functional Departmental Area, Regina Elena National Cancer Institute, Rome, Italy.

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January 2016

Antibody Array as a Tool for Screening of Natural Agents in Cancer Chemoprevention.

Authors:

Claudio Pulito Andrea Sacconi Etleva Korita Anna Maidecchi Sabrina Strano

Methods Mol Biol 2016 ;1379:189-99

Molecular Chemoprevention Unit, Molecular Medicine Area, Italian National Cancer Institute "Regina Elena", via Elio Chianesi, 53, Rome, 00144, Italy.

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September 2016

Circulating miR-21-5p and miR-148a-3p as emerging non-invasive biomarkers in thymic epithelial tumors.

Authors:

Teresa Bellissimo Emanuele Russo Federica Ganci Carmen Vico Andrea Sacconi Flavia Longo Domenico Vitolo Marco Anile Daniele Disio Mirella Marino Giovanni Blandino Federico Venuta Francesco Fazi

Cancer Biol Ther 2016 ;17(1):79-82

a Department of Anatomical, Histological , Forensic and orthopedic Sciences, Section of Histology & Medical Embryology, Sapienza University of Rome , Rome , Italy.

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October 2016

Epigenetic silencing of miR-145-5p contributes to brain metastasis.

Authors:

Sara Donzelli Federica Mori Teresa Bellissimo Andrea Sacconi Beatrice Casini Tania Frixa Giuseppe Roscilli Luigi Aurisicchio Francesco Facciolo Alfredo Pompili Maria Antonia Carosi Edoardo Pescarmona Oreste Segatto Greg Pond Paola Muti Stefano Telera Sabrina Strano Yosef Yarden Giovanni Blandino

Oncotarget 2015 Nov;6(34):35183-201

Translational Oncogenomics Unit, Italian National Cancer Institute 'Regina Elena', Rome, Italy.

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November 2015

Cynara scolymus affects malignant pleural mesothelioma by promoting apoptosis and restraining invasion.

Authors:

Claudio Pulito Federica Mori Andrea Sacconi Luca Casadei Maria Ferraiuolo Maria Cristina Valerio Raffaela Santoro Frauke Goeman Anna Maidecchi Luisa Mattoli Cesare Manetti Silvia Di Agostino Paola Muti Giovanni Blandino Sabrina Strano

Oncotarget 2015 Jul;6(20):18134-50

Molecular Chemoprevention Unit, Molecular Medicine Area, Regina Elena National Cancer Institute, Rome, Italy.

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July 2015

miR-181c associates with tumor relapse of high grade osteosarcoma.

Authors:

Federica Mori Andrea Sacconi Valeria Canu Federica Ganci Mariangela Novello Vincenzo Anelli Renato Covello Virginia Ferraresi Paola Muti Roberto Biagini Giovanni Blandino Sabrina Strano

Oncotarget 2015 Jun;6(16):13946-61

Molecular Chemoprevention Unit, Regina Elena National Cancer Institute, Rome, Italy.

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June 2015

Cdx2 polymorphism affects the activities of vitamin D receptor in human breast cancer cell lines and human breast carcinomas.

Authors:

Claudio Pulito Irene Terrenato Anna Di Benedetto Etleva Korita Frauke Goeman Andrea Sacconi Francesca Biagioni Giovanni Blandino Sabrina Strano Paola Muti Marcella Mottolese Elisabetta Falvo

PLoS One 2015 7;10(4):e0124894. Epub 2015 Apr 7.

Laboratory of Pharmacogenomics (Area Molecular Medicine), Regina Elena National Cancer Institute, Rome, Italy.

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April 2016

Gain of function mutant p53 proteins cooperate with E2F4 to transcriptionally downregulate RAD17 and BRCA1 gene expression.

Authors:

Fabio Valenti Federica Ganci Giulia Fontemaggi Andrea Sacconi Sabrina Strano Giovanni Blandino Silvia Di Agostino

Oncotarget 2015 Mar;6(8):5547-66

Translational Oncogenomic Unit, Molecular Medicine Area, Regina Elena National Cancer Institute, Rome 00144, Italy.

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March 2015

MicroRNA expression as predictor of local recurrence risk in oral squamous cell carcinoma.

Authors:

Federica Ganci Andrea Sacconi Valentina Manciocco Isabella Sperduti Paolo Battaglia Renato Covello Paola Muti Sabrina Strano Giuseppe Spriano Giulia Fontemaggi Giovanni Blandino

Head Neck 2016 04 24;38 Suppl 1:E189-97. Epub 2015 Jun 24.

Translational Oncogenomics Unit, Italian National Cancer Institute "Regina Elena", Rome, Italy.

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April 2016

Downregulation of microRNAs 145-3p and 145-5p is a long-term predictor of postmenopausal breast cancer risk: The ORDET prospective study.

Authors:

Paola Muti Andrea Sacconi Ahmed Hossain Sara Donzelli Noa Bossel Ben Moshe Federica Ganci Sabina Sieri Vittorio Krogh Franco Berrino Francesca Biagioni Sabrina Strano Joseph Beyene Yosef Yarden Giovanni Blandino

Cancer Epidemiol Biomarkers Prev 2014 Nov 29;23(11):2471-81. Epub 2014 Jul 29.

Department of Oncology, Faculty of Health Science, McMaster University, Hamilton, Ontario, Canada. Translational Oncogenomics Unit, Regina Elena Italian National Cancer Institute, Rome, Italy.

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November 2014

Metformin-induced metabolic reprogramming of chemoresistant ALDHbright breast cancer cells.

Authors:

Mario Cioce MariaCristina Valerio Luca Casadei Claudio Pulito Andrea Sacconi Federica Mori Francesca Biagioni Cesare Manetti Paola Muti Sabrina Strano Giovanni Blandino

Oncotarget 2014 Jun;5(12):4129-43

Molecular Chemoprevention Group, Italian National Cancer Institute "Regina Elena", Rome, Italy.

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June 2014

miR-155 drives telomere fragility in human breast cancer by targeting TRF1.

Authors:

Roberto Dinami Cristiana Ercolani Eleonora Petti Silvano Piazza Yari Ciani Rosanna Sestito Andrea Sacconi Francesca Biagioni Carlos le Sage Reuven Agami Roberta Benetti Marcella Mottolese Claudio Schneider Giovanni Blandino Stefan Schoeftner

Cancer Res 2014 Aug 29;74(15):4145-56. Epub 2014 May 29.

Telomeres in Cancer and Aging Unit, Telomeres in Cancer and Aging Unit,

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August 2014

MicroRNA expression profiling of thymic epithelial tumors.

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Federica Ganci Carmen Vico Etleva Korita Andrea Sacconi Enzo Gallo Federica Mori Annamaria Cambria Emanuele Russo Marco Anile Domenico Vitolo Edoardo Pescarmona Rosario Blandino Francesco Facciolo Federico Venuta Giovanni Blandino Mirella Marino Francesco Fazi

Lung Cancer 2014 Aug 29;85(2):197-204. Epub 2014 Apr 29.

Department of Anatomical, Histological, Forensic & Orthopaedic Sciences, Section of Histology & Medical Embryology, Sapienza University of Rome, Rome, Italy. Electronic address:

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August 2014