Publications by authors named "Andrea Pellagatti"

85Publications

SF3B1 mutant myelodysplastic syndrome: Recent advances.

Authors:
Andrea Pellagatti Jacqueline Boultwood

Adv Biol Regul 2020 Dec 22:100776. Epub 2020 Dec 22.

Blood Cancer UK Molecular Haematology Unit, Nuffield Division of Clinical Laboratory Sciences, Radcliffe Department of Medicine, University of Oxford, And NIHR Oxford BRC Haematology Theme, Oxford, UK. Electronic address:

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December 2020

Spliceosome mutations: 1 plus 1 does not always equal 2.

Authors:
Andrea Pellagatti Jacqueline Boultwood

Blood 2020 Sep;136(13):1471-1472

University of Oxford.

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September 2020

Phospholipase C beta1 (PI-PLCbeta1)/Cyclin D3/protein kinase C (PKC) alpha signaling modulation during iron-induced oxidative stress in myelodysplastic syndromes (MDS).

Authors:
Alessandra Cappellini Sara Mongiorgi Carlo Finelli Antonietta Fazio Stefano Ratti Maria Vittoria Marvi Antonio Curti Valentina Salvestrini Andrea Pellagatti Anna Maria Billi Pann-Ghill Suh James A McCubrey Jacqueline Boultwood Lucia Manzoli Lucio Cocco Matilde Y Follo

FASEB J 2020 Nov 22;34(11):15400-15416. Epub 2020 Sep 22.

Cellular Signalling Laboratory, Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy.

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November 2020

Implications of TP53 allelic state for genome stability, clinical presentation and outcomes in myelodysplastic syndromes.

Authors:
Elsa Bernard Yasuhito Nannya Robert P Hasserjian Sean M Devlin Heinz Tuechler Juan S Medina-Martinez Tetsuichi Yoshizato Yusuke Shiozawa Ryunosuke Saiki Luca Malcovati Max F Levine Juan E Arango Yangyu Zhou Francesc Solé Catherine A Cargo Detlef Haase Maria Creignou Ulrich Germing Yanming Zhang Gunes Gundem Araxe Sarian Arjan A van de Loosdrecht Martin Jädersten Magnus Tobiasson Olivier Kosmider Matilde Y Follo Felicitas Thol Ronald F Pinheiro Valeria Santini Ioannis Kotsianidis Jacqueline Boultwood Fabio P S Santos Julie Schanz Senji Kasahara Takayuki Ishikawa Hisashi Tsurumi Akifumi Takaori-Kondo Toru Kiguchi Chantana Polprasert John M Bennett Virginia M Klimek Michael R Savona Monika Belickova Christina Ganster Laura Palomo Guillermo Sanz Lionel Ades Matteo Giovanni Della Porta Alexandra G Smith Yesenia Werner Minal Patel Agnès Viale Katelynd Vanness Donna S Neuberg Kristen E Stevenson Kamal Menghrajani Kelly L Bolton Pierre Fenaux Andrea Pellagatti Uwe Platzbecker Michael Heuser Peter Valent Shigeru Chiba Yasushi Miyazaki Carlo Finelli Maria Teresa Voso Lee-Yung Shih Michaela Fontenay Joop H Jansen José Cervera Yoshiko Atsuta Norbert Gattermann Benjamin L Ebert Rafael Bejar Peter L Greenberg Mario Cazzola Eva Hellström-Lindberg Seishi Ogawa Elli Papaemmanuil

Nat Med 2020 10 3;26(10):1549-1556. Epub 2020 Aug 3.

Computational Oncology Service, Department of Epidemiology & Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

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October 2020

SF3B1-mutant MDS as a distinct disease subtype: a proposal from the International Working Group for the Prognosis of MDS.

Authors:
Luca Malcovati Kristen Stevenson Elli Papaemmanuil Donna Neuberg Rafael Bejar Jacqueline Boultwood David T Bowen Peter J Campbell Benjamin L Ebert Pierre Fenaux Torsten Haferlach Michael Heuser Joop H Jansen Rami S Komrokji Jaroslaw P Maciejewski Matthew J Walter Michaela Fontenay Guillermo Garcia-Manero Timothy A Graubert Aly Karsan Manja Meggendorfer Andrea Pellagatti David A Sallman Michael R Savona Mikkael A Sekeres David P Steensma Sudhir Tauro Felicitas Thol Paresh Vyas Arjan A Van de Loosdrecht Detlef Haase Heinz Tüchler Peter L Greenberg Seishi Ogawa Eva Hellstrom-Lindberg Mario Cazzola

Blood 2020 Jul;136(2):157-170

Department of Molecular Medicine, University of Pavia & Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.

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July 2020

SF3B1 mutations induce R-loop accumulation and DNA damage in MDS and leukemia cells with therapeutic implications.

Authors:
Shalini Singh Doaa Ahmed Hamid Dolatshad Dharamveer Tatwavedi Ulrike Schulze Andrea Sanchi Sarah Ryley Ashish Dhir Lee Carpenter Suzanne M Watt David J Roberts Amal M Abdel-Aal Sohair K Sayed Somaia A Mohamed Anna Schuh Paresh Vyas Sally Killick Andriana G Kotini Eirini P Papapetrou Daniel H Wiseman Andrea Pellagatti Jacqueline Boultwood

Leukemia 2020 09 19;34(9):2525-2530. Epub 2020 Feb 19.

Bloodwise Molecular Haematology Unit, Nuffield Division of Clinical Laboratory Sciences, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.

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September 2020

Non-del(5q) myelodysplastic syndromes-associated loci detected by SNP-array genome-wide association meta-analysis.

Authors:
Kathy L McGraw Chia-Ho Cheng Y Ann Chen Hsin-An Hou Björn Nilsson Giulio Genovese Thomas Cluzeau Andrea Pellagatti Bartlomiej P Przychodzen Mar Mallo Leonor Arenillas Azim Mohamedali Lionel Adès David A Sallman Eric Padron Lubomir Sokol Chimene Moreilhon Sophie Raynaud Hwei-Fang Tien Jacqueline Boultwood Benjamin L Ebert Francesc Sole Pierre Fenaux Ghulam J Mufti Jaroslaw P Maciejewski Peter A Kanetsky Alan F List

Blood Adv 2019 11;3(22):3579-3589

Department of Malignant Hematology and.

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November 2019

Recent advances in MDS mutation landscape: Splicing and signalling.

Authors:
Matilde Y Follo Andrea Pellagatti Stefano Ratti Giulia Ramazzotti Irene Faenza Roberta Fiume Sara Mongiorgi Pann-Ghill Suh James A McCubrey Lucia Manzoli Jacqueline Boultwood Lucio Cocco

Adv Biol Regul 2020 01 5;75:100673. Epub 2019 Nov 5.

Cellular Signalling Laboratory, Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy.

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January 2020

Splicing factor mutant myelodysplastic syndromes: Recent advances.

Authors:
Andrea Pellagatti Jacqueline Boultwood

Adv Biol Regul 2020 01 19;75:100655. Epub 2019 Sep 19.

Bloodwise Molecular Haematology Unit, Nuffield Division of Clinical Laboratory Sciences, Radcliffe Department of Medicine, University of Oxford, Oxford BRC Haematology Theme, Oxford, UK. Electronic address:

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January 2020

U2AF1 mutations induce oncogenic IRAK4 isoforms and activate innate immune pathways in myeloid malignancies.

Authors:
Molly A Smith Gaurav S Choudhary Andrea Pellagatti Kwangmin Choi Lyndsey C Bolanos Tushar D Bhagat Shanisha Gordon-Mitchell Dagny Von Ahrens Kith Pradhan Violetta Steeples Sanghyun Kim Ulrich Steidl Matthew Walter Iain D C Fraser Aishwarya Kulkarni Nathan Salomonis Kakajan Komurov Jacqueline Boultwood Amit Verma Daniel T Starczynowski

Nat Cell Biol 2019 05 22;21(5):640-650. Epub 2019 Apr 22.

Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.

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May 2019

Response of high-risk MDS to azacitidine and lenalidomide is impacted by baseline and acquired mutations in a cluster of three inositide-specific genes.

Authors:
Matilde Y Follo Andrea Pellagatti Richard N Armstrong Stefano Ratti Sara Mongiorgi Sara De Fanti Maria Teresa Bochicchio Domenico Russo Marco Gobbi Maurizio Miglino Sarah Parisi Giovanni Martinelli Michele Cavo Donata Luiselli James A McCubrey Pann-Ghill Suh Lucia Manzoli Jacqueline Boultwood Carlo Finelli Lucio Cocco

Leukemia 2019 09 20;33(9):2276-2290. Epub 2019 Feb 20.

Cellular Signalling Laboratory, Human Anatomy Section, Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy.

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September 2019

TP53 mutation status divides myelodysplastic syndromes with complex karyotypes into distinct prognostic subgroups.

Authors:
Detlef Haase Kristen E Stevenson Donna Neuberg Jaroslaw P Maciejewski Aziz Nazha Mikkael A Sekeres Benjamin L Ebert Guillermo Garcia-Manero Claudia Haferlach Torsten Haferlach Wolfgang Kern Seishi Ogawa Yasunobu Nagata Kenichi Yoshida Timothy A Graubert Matthew J Walter Alan F List Rami S Komrokji Eric Padron David Sallman Elli Papaemmanuil Peter J Campbell Michael R Savona Adam Seegmiller Lionel Adès Pierre Fenaux Lee-Yung Shih David Bowen Michael J Groves Sudhir Tauro Michaela Fontenay Olivier Kosmider Michal Bar-Natan David Steensma Richard Stone Michael Heuser Felicitas Thol Mario Cazzola Luca Malcovati Aly Karsan Christina Ganster Eva Hellström-Lindberg Jacqueline Boultwood Andrea Pellagatti Valeria Santini Lynn Quek Paresh Vyas Heinz Tüchler Peter L Greenberg Rafael Bejar

Leukemia 2019 07 11;33(7):1747-1758. Epub 2019 Jan 11.

UC San Diego Moores Cancer Center, La Jolla, CA, USA.

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July 2019

PRR14L mutations are associated with chromosome 22 acquired uniparental disomy, age-related clonal hematopoiesis and myeloid neoplasia.

Authors:
Andrew Chase Andrea Pellagatti Shalini Singh Joannah Score William J Tapper Feng Lin Yvette Hoade Catherine Bryant Nicola Trim Bon Ham Yip Katerina Zoi Chiara Rasi Lars A Forsberg Jan P Dumanski Jacqueline Boultwood Nicholas C P Cross

Leukemia 2019 05 20;33(5):1184-1194. Epub 2018 Dec 20.

Faculty of Medicine, University of Southampton, Southampton, UK.

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May 2019

Application of induced pluripotent stem cell technology for the investigation of hematological disorders.

Authors:
Hamid Dolatshad Dharamveer Tatwavedi Doaa Ahmed Jana F Tegethoff Jacqueline Boultwood Andrea Pellagatti

Adv Biol Regul 2019 01 10;71:19-33. Epub 2018 Oct 10.

Bloodwise Molecular Haematology Unit, Nuffield Division of Clinical Laboratory Sciences, Radcliffe Department of Medicine, University of Oxford, and Oxford BRC Haematology Theme, Oxford, UK. Electronic address:

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January 2019

Cell-specific proteome analyses of human bone marrow reveal molecular features of age-dependent functional decline.

Authors:
Marco L Hennrich Natalie Romanov Patrick Horn Samira Jaeger Volker Eckstein Violetta Steeples Fei Ye Ximing Ding Laura Poisa-Beiro Mang Ching Lai Benjamin Lang Jacqueline Boultwood Thomas Luft Judith B Zaugg Andrea Pellagatti Peer Bork Patrick Aloy Anne-Claude Gavin Anthony D Ho

Nat Commun 2018 10 1;9(1):4004. Epub 2018 Oct 1.

Molecular Medicine Partnership Unit (MMPU), Meyerhofstrasse 1, Heidelberg, D69117, Germany.

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October 2018

Antisense STAT3 inhibitor decreases viability of myelodysplastic and leukemic stem cells.

Authors:
Aditi Shastri Gaurav Choudhary Margarida Teixeira Shanisha Gordon-Mitchell Nandini Ramachandra Lumie Bernard Sanchari Bhattacharyya Robert Lopez Kith Pradhan Orsolya Giricz Goutham Ravipati Li-Fan Wong Sally Cole Tushar D Bhagat Jonathan Feld Yosman Dhar Matthias Bartenstein Victor J Thiruthuvanathan Amittha Wickrema B Hilda Ye David A Frank Andrea Pellagatti Jacqueline Boultwood Tianyuan Zhou Youngsoo Kim A Robert MacLeod P K Epling-Burnette Minwei Ye Patricia McCoon Richard Woessner Ulrich Steidl Britta Will Amit Verma

J Clin Invest 2018 12 5;128(12):5479-5488. Epub 2018 Nov 5.

Albert Einstein College of Medicine, New York, New York, USA.

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December 2018

SIRT1 Activation Disrupts Maintenance of Myelodysplastic Syndrome Stem and Progenitor Cells by Restoring TET2 Function.

Authors:
Jie Sun Xin He Yinghui Zhu Zonghui Ding Haojie Dong Yimei Feng Juan Du Hanying Wang Xiwei Wu Lei Zhang Xiaochun Yu Allen Lin Tinisha McDonald Dandan Zhao Herman Wu Wei-Kai Hua Bin Zhang Lifeng Feng Kaoru Tohyama Ravi Bhatia Philipp Oberdoerffer Yang Jo Chung Peter D Aplan Jacqueline Boultwood Andrea Pellagatti Samer Khaled Marcin Kortylewski Flavia Pichiorri Ya-Huei Kuo Nadia Carlesso Guido Marcucci Hongchuan Jin Ling Li

Cell Stem Cell 2018 09 23;23(3):355-369.e9. Epub 2018 Aug 23.

Department of Hematological Malignancies Translational Science, Gehr Family Center for Leukemia Research, Hematologic Malignancies and Stem Cell Transplantation Institute, Beckman Research Institute, City of Hope Medical Center, Duarte, CA 91010, USA. Electronic address:

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September 2018

Impact of spliceosome mutations on RNA splicing in myelodysplasia: dysregulated genes/pathways and clinical associations.

Authors:
Andrea Pellagatti Richard N Armstrong Violetta Steeples Eshita Sharma Emmanouela Repapi Shalini Singh Andrea Sanchi Aleksandar Radujkovic Patrick Horn Hamid Dolatshad Swagata Roy John Broxholme Helen Lockstone Stephen Taylor Aristoteles Giagounidis Paresh Vyas Anna Schuh Angela Hamblin Elli Papaemmanuil Sally Killick Luca Malcovati Marco L Hennrich Anne-Claude Gavin Anthony D Ho Thomas Luft Eva Hellström-Lindberg Mario Cazzola Christopher W J Smith Stephen Smith Jacqueline Boultwood

Blood 2018 09 21;132(12):1225-1240. Epub 2018 Jun 21.

Nuffield Division of Clinical Laboratory Sciences, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom.

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September 2018

L-leucine increases translation of and in erythroblasts from del(5q) myelodysplastic syndrome patients.

Authors:
Erica Bello Jonathan Kerry Shalini Singh Bon Ham Yip Rajko Kušec Sally Killick Sophie Raynaud Jacqueline Boultwood Andrea Pellagatti

Haematologica 2018 11 14;103(11):e496-e500. Epub 2018 Jun 14.

Bloodwise Molecular Haematology Unit, Nuffield Division of Clinical Laboratory Sciences, Radcliffe Department of Medicine, University of Oxford, and Oxford BRC Haematology Theme, UK

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November 2018

Gene expression and risk of leukemic transformation in myelodysplasia.

Authors:
Yusuke Shiozawa Luca Malcovati Anna Gallì Andrea Pellagatti Mohsen Karimi Aiko Sato-Otsubo Yusuke Sato Hiromichi Suzuki Tetsuichi Yoshizato Kenichi Yoshida Yuichi Shiraishi Kenichi Chiba Hideki Makishima Jacqueline Boultwood Eva Hellström-Lindberg Satoru Miyano Mario Cazzola Seishi Ogawa

Blood 2017 12 2;130(24):2642-2653. Epub 2017 Nov 2.

Department of Pathology and Tumor Biology, Kyoto University, Kyoto, Japan.

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December 2017