Andrea Pellagatti

Andrea Pellagatti

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Andrea Pellagatti

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Response of high-risk MDS to azacitidine and lenalidomide is impacted by baseline and acquired mutations in a cluster of three inositide-specific genes.

Authors:
Matilde Y Follo Andrea Pellagatti Richard N Armstrong Stefano Ratti Sara Mongiorgi Sara De Fanti Maria Teresa Bochicchio Domenico Russo Marco Gobbi Maurizio Miglino Sarah Parisi Giovanni Martinelli Michele Cavo Donata Luiselli James A McCubrey Pann-Ghill Suh Lucia Manzoli Jacqueline Boultwood Carlo Finelli Lucio Cocco

Leukemia 2019 Sep 20;33(9):2276-2290. Epub 2019 Feb 20.

Cellular Signalling Laboratory, Human Anatomy Section, Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy.

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http://www.nature.com/articles/s41375-019-0416-x
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http://dx.doi.org/10.1038/s41375-019-0416-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6733710PMC
September 2019

Splicing factor mutant myelodysplastic syndromes: Recent advances.

Authors:
Andrea Pellagatti Jacqueline Boultwood

Adv Biol Regul 2019 Sep 19:100655. Epub 2019 Sep 19.

Bloodwise Molecular Haematology Unit, Nuffield Division of Clinical Laboratory Sciences, Radcliffe Department of Medicine, University of Oxford, Oxford BRC Haematology Theme, Oxford, UK. Electronic address:

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http://dx.doi.org/10.1016/j.jbior.2019.100655DOI Listing
September 2019

TP53 mutation status divides myelodysplastic syndromes with complex karyotypes into distinct prognostic subgroups.

Authors:
Detlef Haase Kristen E Stevenson Donna Neuberg Jaroslaw P Maciejewski Aziz Nazha Mikkael A Sekeres Benjamin L Ebert Guillermo Garcia-Manero Claudia Haferlach Torsten Haferlach Wolfgang Kern Seishi Ogawa Yasunobu Nagata Kenichi Yoshida Timothy A Graubert Matthew J Walter Alan F List Rami S Komrokji Eric Padron David Sallman Elli Papaemmanuil Peter J Campbell Michael R Savona Adam Seegmiller Lionel Adès Pierre Fenaux Lee-Yung Shih David Bowen Michael J Groves Sudhir Tauro Michaela Fontenay Olivier Kosmider Michal Bar-Natan David Steensma Richard Stone Michael Heuser Felicitas Thol Mario Cazzola Luca Malcovati Aly Karsan Christina Ganster Eva Hellström-Lindberg Jacqueline Boultwood Andrea Pellagatti Valeria Santini Lynn Quek Paresh Vyas Heinz Tüchler Peter L Greenberg Rafael Bejar

Leukemia 2019 07 11;33(7):1747-1758. Epub 2019 Jan 11.

UC San Diego Moores Cancer Center, La Jolla, CA, USA.

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http://dx.doi.org/10.1038/s41375-018-0351-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6609480PMC
July 2019

PRR14L mutations are associated with chromosome 22 acquired uniparental disomy, age-related clonal hematopoiesis and myeloid neoplasia.

Authors:
Andrew Chase Andrea Pellagatti Shalini Singh Joannah Score William J Tapper Feng Lin Yvette Hoade Catherine Bryant Nicola Trim Bon Ham Yip Katerina Zoi Chiara Rasi Lars A Forsberg Jan P Dumanski Jacqueline Boultwood Nicholas C P Cross

Leukemia 2019 05 20;33(5):1184-1194. Epub 2018 Dec 20.

Faculty of Medicine, University of Southampton, Southampton, UK.

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http://dx.doi.org/10.1038/s41375-018-0340-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451636PMC
May 2019

U2AF1 mutations induce oncogenic IRAK4 isoforms and activate innate immune pathways in myeloid malignancies.

Authors:
Molly A Smith Gaurav S Choudhary Andrea Pellagatti Kwangmin Choi Lyndsey C Bolanos Tushar D Bhagat Shanisha Gordon-Mitchell Dagny Von Ahrens Kith Pradhan Violetta Steeples Sanghyun Kim Ulrich Steidl Matthew Walter Iain D C Fraser Aishwarya Kulkarni Nathan Salomonis Kakajan Komurov Jacqueline Boultwood Amit Verma Daniel T Starczynowski

Nat Cell Biol 2019 05 22;21(5):640-650. Epub 2019 Apr 22.

Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.

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http://dx.doi.org/10.1038/s41556-019-0314-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6679973PMC
May 2019

Application of induced pluripotent stem cell technology for the investigation of hematological disorders.

Authors:
Hamid Dolatshad Dharamveer Tatwavedi Doaa Ahmed Jana F Tegethoff Jacqueline Boultwood Andrea Pellagatti

Adv Biol Regul 2019 Jan 10;71:19-33. Epub 2018 Oct 10.

Bloodwise Molecular Haematology Unit, Nuffield Division of Clinical Laboratory Sciences, Radcliffe Department of Medicine, University of Oxford, and Oxford BRC Haematology Theme, Oxford, UK. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22124926183014
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http://dx.doi.org/10.1016/j.jbior.2018.10.001DOI Listing
January 2019

Antisense STAT3 inhibitor decreases viability of myelodysplastic and leukemic stem cells.

Authors:
Aditi Shastri Gaurav Choudhary Margarida Teixeira Shanisha Gordon-Mitchell Nandini Ramachandra Lumie Bernard Sanchari Bhattacharyya Robert Lopez Kith Pradhan Orsolya Giricz Goutham Ravipati Li-Fan Wong Sally Cole Tushar D Bhagat Jonathan Feld Yosman Dhar Matthias Bartenstein Victor J Thiruthuvanathan Amittha Wickrema B Hilda Ye David A Frank Andrea Pellagatti Jacqueline Boultwood Tianyuan Zhou Youngsoo Kim A Robert MacLeod P K Epling-Burnette Minwei Ye Patricia McCoon Richard Woessner Ulrich Steidl Britta Will Amit Verma

J Clin Invest 2018 12 5;128(12):5479-5488. Epub 2018 Nov 5.

Albert Einstein College of Medicine, New York, New York, USA.

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http://dx.doi.org/10.1172/JCI120156DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6264739PMC
December 2018

L-leucine increases translation of and in erythroblasts from del(5q) myelodysplastic syndrome patients.

Authors:
Erica Bello Jonathan Kerry Shalini Singh Bon Ham Yip Rajko Kušec Sally Killick Sophie Raynaud Jacqueline Boultwood Andrea Pellagatti

Haematologica 2018 11 14;103(11):e496-e500. Epub 2018 Jun 14.

Bloodwise Molecular Haematology Unit, Nuffield Division of Clinical Laboratory Sciences, Radcliffe Department of Medicine, University of Oxford, and Oxford BRC Haematology Theme, UK

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http://dx.doi.org/10.3324/haematol.2018.190447DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6278984PMC
November 2018

Cell-specific proteome analyses of human bone marrow reveal molecular features of age-dependent functional decline.

Authors:
Marco L Hennrich Natalie Romanov Patrick Horn Samira Jaeger Volker Eckstein Violetta Steeples Fei Ye Ximing Ding Laura Poisa-Beiro Mang Ching Lai Benjamin Lang Jacqueline Boultwood Thomas Luft Judith B Zaugg Andrea Pellagatti Peer Bork Patrick Aloy Anne-Claude Gavin Anthony D Ho

Nat Commun 2018 10 1;9(1):4004. Epub 2018 Oct 1.

Molecular Medicine Partnership Unit (MMPU), Meyerhofstrasse 1, Heidelberg, D69117, Germany.

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http://www.nature.com/articles/s41467-018-06353-4
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http://dx.doi.org/10.1038/s41467-018-06353-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6167374PMC
October 2018

Impact of spliceosome mutations on RNA splicing in myelodysplasia: dysregulated genes/pathways and clinical associations.

Authors:
Andrea Pellagatti Richard N Armstrong Violetta Steeples Eshita Sharma Emmanouela Repapi Shalini Singh Andrea Sanchi Aleksandar Radujkovic Patrick Horn Hamid Dolatshad Swagata Roy John Broxholme Helen Lockstone Stephen Taylor Aristoteles Giagounidis Paresh Vyas Anna Schuh Angela Hamblin Elli Papaemmanuil Sally Killick Luca Malcovati Marco L Hennrich Anne-Claude Gavin Anthony D Ho Thomas Luft Eva Hellström-Lindberg Mario Cazzola Christopher W J Smith Stephen Smith Jacqueline Boultwood

Blood 2018 09 21;132(12):1225-1240. Epub 2018 Jun 21.

Nuffield Division of Clinical Laboratory Sciences, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom.

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http://dx.doi.org/10.1182/blood-2018-04-843771DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6172604PMC
September 2018

SIRT1 Activation Disrupts Maintenance of Myelodysplastic Syndrome Stem and Progenitor Cells by Restoring TET2 Function.

Authors:
Jie Sun Xin He Yinghui Zhu Zonghui Ding Haojie Dong Yimei Feng Juan Du Hanying Wang Xiwei Wu Lei Zhang Xiaochun Yu Allen Lin Tinisha McDonald Dandan Zhao Herman Wu Wei-Kai Hua Bin Zhang Lifeng Feng Kaoru Tohyama Ravi Bhatia Philipp Oberdoerffer Yang Jo Chung Peter D Aplan Jacqueline Boultwood Andrea Pellagatti Samer Khaled Marcin Kortylewski Flavia Pichiorri Ya-Huei Kuo Nadia Carlesso Guido Marcucci Hongchuan Jin Ling Li

Cell Stem Cell 2018 09 23;23(3):355-369.e9. Epub 2018 Aug 23.

Department of Hematological Malignancies Translational Science, Gehr Family Center for Leukemia Research, Hematologic Malignancies and Stem Cell Transplantation Institute, Beckman Research Institute, City of Hope Medical Center, Duarte, CA 91010, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2018.07.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6143172PMC
September 2018

Splicing factor mutations in the myelodysplastic syndromes: target genes and therapeutic approaches.

Authors:
Richard N Armstrong Violetta Steeples Shalini Singh Andrea Sanchi Jacqueline Boultwood Andrea Pellagatti

Adv Biol Regul 2018 01 22;67:13-29. Epub 2017 Sep 22.

Bloodwise Molecular Haematology Unit, Nuffield Division of Clinical Laboratory Sciences, Radcliffe Department of Medicine, University of Oxford, and Oxford BRC Haematology Theme, Oxford, UK. Electronic address:

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http://dx.doi.org/10.1016/j.jbior.2017.09.008DOI Listing
January 2018

Gene expression and risk of leukemic transformation in myelodysplasia.

Authors:
Yusuke Shiozawa Luca Malcovati Anna Gallì Andrea Pellagatti Mohsen Karimi Aiko Sato-Otsubo Yusuke Sato Hiromichi Suzuki Tetsuichi Yoshizato Kenichi Yoshida Yuichi Shiraishi Kenichi Chiba Hideki Makishima Jacqueline Boultwood Eva Hellström-Lindberg Satoru Miyano Mario Cazzola Seishi Ogawa

Blood 2017 12 2;130(24):2642-2653. Epub 2017 Nov 2.

Department of Pathology and Tumor Biology, Kyoto University, Kyoto, Japan.

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http://dx.doi.org/10.1182/blood-2017-05-783050DOI Listing
December 2017

Impact of Splicing Factor Mutations on Pre-mRNA Splicing in the Myelodysplastic Syndromes.

Authors:
Bon Ham Yip Hamid Dolatshad Swagata Roy Andrea Pellagatti Jacqueline Boultwood

Curr Pharm Des 2016 ;22(16):2333-44

Nuffield Division of Clinical Laboratory Sciences, Radcliffe Department of Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, United Kingdom.

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http://dx.doi.org/10.2174/1381612822666160226132112DOI Listing
November 2017

Epigenetically Aberrant Stroma in MDS Propagates Disease via Wnt/β-Catenin Activation.

Authors:
Tushar D Bhagat Si Chen Matthias Bartenstein A Trevor Barlowe Dagny Von Ahrens Gaurav S Choudhary Patrick Tivnan Elianna Amin A Mario Marcondes Mathijs A Sanders Remco M Hoogenboezem Suman Kambhampati Nandini Ramachandra Iaonnis Mantzaris Vineeth Sukrithan Remi Laurence Robert Lopez Prafullla Bhagat Orsi Giricz Davendra Sohal Amittha Wickrema Cecilia Yeung Kira Gritsman Peter Aplan Konrad Hochedlinger Yiting Yu Kith Pradhan Jinghang Zhang John M Greally Siddhartha Mukherjee Andrea Pellagatti Jacqueline Boultwood Britta Will Ulrich Steidl Marc H G P Raaijmakers H Joachim Deeg Michael G Kharas Amit Verma

Cancer Res 2017 09 6;77(18):4846-4857. Epub 2017 Jul 6.

Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, New York.

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http://dx.doi.org/10.1158/0008-5472.CAN-17-0282DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5600853PMC
September 2017

The U2AF1S34F mutation induces lineage-specific splicing alterations in myelodysplastic syndromes.

Authors:
Bon Ham Yip Violetta Steeples Emmanouela Repapi Richard N Armstrong Miriam Llorian Swagata Roy Jacqueline Shaw Hamid Dolatshad Stephen Taylor Amit Verma Matthias Bartenstein Paresh Vyas Nicholas Cp Cross Luca Malcovati Mario Cazzola Eva Hellström-Lindberg Seishi Ogawa Christopher Wj Smith Andrea Pellagatti Jacqueline Boultwood

J Clin Invest 2017 09 1;127(9):3557. Epub 2017 Sep 1.

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http://dx.doi.org/10.1172/JCI96202DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5669537PMC
September 2017

Integrative Genomics Identifies the Molecular Basis of Resistance to Azacitidine Therapy in Myelodysplastic Syndromes.

Authors:
Ashwin Unnikrishnan Elli Papaemmanuil Dominik Beck Nandan P Deshpande Arjun Verma Ashu Kumari Petter S Woll Laura A Richards Kathy Knezevic Vashe Chandrakanthan Julie A I Thoms Melinda L Tursky Yizhou Huang Zara Ali Jake Olivier Sally Galbraith Austin G Kulasekararaj Magnus Tobiasson Mohsen Karimi Andrea Pellagatti Susan R Wilson Robert Lindeman Boris Young Raj Ramakrishna Christopher Arthur Richard Stark Philip Crispin Jennifer Curnow Pauline Warburton Fernando Roncolato Jacqueline Boultwood Kevin Lynch Sten Eirik W Jacobsen Ghulam J Mufti Eva Hellstrom-Lindberg Marc R Wilkins Karen L MacKenzie Jason W H Wong Peter J Campbell John E Pimanda

Cell Rep 2017 07;20(3):572-585

Adult Cancer Program, Lowy Cancer Research Centre, UNSW, Sydney, NSW 2052, Australia; Prince of Wales Clinical School, UNSW, Sydney, NSW 2052, Australia; Haematology Department, South Eastern Area Laboratory Services, Prince of Wales Hospital, Randwick, NSW 2031, Australia. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22111247173089
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http://dx.doi.org/10.1016/j.celrep.2017.06.067DOI Listing
July 2017

The U2AF1S34F mutation induces lineage-specific splicing alterations in myelodysplastic syndromes.

Authors:
Bon Ham Yip Violetta Steeples Emmanouela Repapi Richard N Armstrong Miriam Llorian Swagata Roy Jacqueline Shaw Hamid Dolatshad Stephen Taylor Amit Verma Matthias Bartenstein Paresh Vyas Nicholas Cp Cross Luca Malcovati Mario Cazzola Eva Hellström-Lindberg Seishi Ogawa Christopher Wj Smith Andrea Pellagatti Jacqueline Boultwood

J Clin Invest 2017 Jun 24;127(6):2206-2221. Epub 2017 Apr 24.

Bloodwise Molecular Haematology Unit, Nuffield Division of Clinical Laboratory Sciences, Radcliffe Department of Medicine, University of Oxford, and BRC Blood Theme, National Institute for Health Research (NIHR) Oxford Biomedical Centre, Oxford University Hospital, Oxford, United Kingdom.

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http://dx.doi.org/10.1172/JCI91363DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5451246PMC
June 2017

Progression in patients with low- and intermediate-1-risk del(5q) myelodysplastic syndromes is predicted by a limited subset of mutations.

Authors:
Christian Scharenberg Valentina Giai Andrea Pellagatti Leonie Saft Marios Dimitriou Monika Jansson Martin Jädersten Alf Grandien Iyadh Douagi Donna S Neuberg Katarina LeBlanc Jacqueline Boultwood Mohsen Karimi Sten Eirik W Jacobsen Petter S Woll Eva Hellström-Lindberg

Haematologica 2017 03 24;102(3):498-508. Epub 2016 Nov 24.

Department of Medicine, Center for Hematology and Regenerative Medicine, Karolinska University Hospital Huddinge, Karolinska Institutet, Stockholm, Sweden

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http://dx.doi.org/10.3324/haematol.2016.152025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5394951PMC
March 2017

Splicing factor gene mutations in the myelodysplastic syndromes: impact on disease phenotype and therapeutic applications.

Authors:
Andrea Pellagatti Jacqueline Boultwood

Adv Biol Regul 2017 Jan 21;63:59-70. Epub 2016 Aug 21.

Bloodwise Molecular Haematology Unit, Nuffield Division of Clinical Laboratory Sciences, Radcliffe Department of Medicine, University of Oxford; NIHR Biomedical Research Centre, Oxford, UK. Electronic address:

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http://dx.doi.org/10.1016/j.jbior.2016.08.001DOI Listing
January 2017

Expression of CDKN1C in the bone marrow of patients with myelodysplastic syndrome and secondary acute myeloid leukemia is associated with poor survival after conventional chemotherapy.

Authors:
Aleksandar Radujkovic Sascha Dietrich Mindaugas Andrulis Axel Benner Thomas Longerich Andrea Pellagatti Kriti Nanda Thomas Giese Ulrich Germing Stefan Baldus Jacqueline Boultwood Anthony D Ho Peter Dreger Thomas Luft

Int J Cancer 2016 09 3;139(6):1402-13. Epub 2016 Jun 3.

Department of Internal Medicine V, University Hospital Heidelberg, Heidelberg, Germany.

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http://doi.wiley.com/10.1002/ijc.30181
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http://dx.doi.org/10.1002/ijc.30181DOI Listing
September 2016

The Effects of Severe Hypoxia on Glycolytic Flux and Enzyme Activity in a Model of Solid Tumors.

Authors:
Hannah Smith Mary Board Andrea Pellagatti Helen Turley Jacqueline Boultwood Richard Callaghan

J Cell Biochem 2016 08 2;117(8):1890-901. Epub 2016 Feb 2.

Nuffield Department of Clinical Laboratory Sciences, John Radcliffe Hospital, The University of Oxford, Headington, UK.

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http://dx.doi.org/10.1002/jcb.25488DOI Listing
August 2016

Pexmetinib: A Novel Dual Inhibitor of Tie2 and p38 MAPK with Efficacy in Preclinical Models of Myelodysplastic Syndromes and Acute Myeloid Leukemia.

Authors:
Lohith Bachegowda Kerry Morrone Shannon L Winski Ioannis Mantzaris Matthias Bartenstein Nandini Ramachandra Orsi Giricz Vineeth Sukrithan George Nwankwo Samira Shahnaz Tushar Bhagat Sanchari Bhattacharyya Amer Assal Aditi Shastri Shanisha Gordon-Mitchell Andrea Pellagatti Jacqueline Boultwood Carolina Schinke Yiting Yu Chandan Guha James Rizzi Jennifer Garrus Suzy Brown Lance Wollenberg Grant Hogeland Dale Wright Mark Munson Mareli Rodriguez Stefan Gross David Chantry Yiyu Zou Leonidas Platanias Laurence E Burgess Kith Pradhan Ulrich Steidl Amit Verma

Cancer Res 2016 08 10;76(16):4841-4849. Epub 2016 Jun 10.

Albert Einstein College of Medicine, Bronx , NY.

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http://dx.doi.org/10.1158/0008-5472.CAN-15-3062DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5398415PMC
August 2016

GFI1(36N) as a therapeutic and prognostic marker for myelodysplastic syndrome.

Authors:
Lacramioara Botezatu Lars C Michel Hideki Makishima Thomas Schroeder Ulrich Germing Rainer Haas Bert van der Reijden Anne E Marneth Saskia M Bergevoet Joop H Jansen Bartlomiej Przychodzen Marcin Wlodarski Charlotte Niemeyer Uwe Platzbecker Gerhard Ehninger Ashwin Unnikrishnan Dominik Beck John Pimanda Eva Hellström-Lindberg Luca Malcovati Jacqueline Boultwood Andrea Pellagatti Elli Papaemmanuil Philipp Le Coutre Jaspal Kaeda Bertram Opalka Tarik Möröy Ulrich Dührsen Jaroslaw Maciejewski Cyrus Khandanpour

Exp Hematol 2016 07 11;44(7):590-595.e1. Epub 2016 Apr 11.

Department of Hematology, West German Cancer Center, University Hospital Essen, University Duisburg-Essen, Essen, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.exphem.2016.04.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4917888PMC
July 2016

Downregulation of Protection of Telomeres 1 expression in myelodysplastic syndromes with 7q deletion.

Authors:
Monica Cabrero Yiting Yu Amit Verma Hui Yang Simona Colla Yu Jia Hong Zheng Zach Bohannan Irene Ganan-Gomez Andrew Futreal Koichi Takahashi Lynda Chin Hagop Kantarjian Andrea Pellagatti Teresa Bowman Jacqueline Boultwood Guillermo Garcia-Manero Yue Wei

Br J Haematol 2016 Apr 24;173(1):161-5. Epub 2015 Jun 24.

Departments of Leukemia, University of Texas MD Anderson Cancer Center, Houston, TX, USA.

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http://dx.doi.org/10.1111/bjh.13574DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5580681PMC
April 2016

Application of genome editing technologies to the study and treatment of hematological disease.

Authors:
Andrea Pellagatti Hamid Dolatshad Bon Ham Yip Simona Valletta Jacqueline Boultwood

Adv Biol Regul 2016 Jan 26;60:122-134. Epub 2015 Sep 26.

Bloodwise Molecular Haematology Unit, Nuffield Division of Clinical Laboratory Sciences, Radcliffe Department of Medicine, University of Oxford, and NIHR Biomedical Research Centre, Oxford, UK. Electronic address:

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http://dx.doi.org/10.1016/j.jbior.2015.09.005DOI Listing
January 2016

ASXL1 mutation correction by CRISPR/Cas9 restores gene function in leukemia cells and increases survival in mouse xenografts.

Authors:
Simona Valletta Hamid Dolatshad Matthias Bartenstein Bon Ham Yip Erica Bello Shanisha Gordon Yiting Yu Jacqueline Shaw Swagata Roy Laura Scifo Anna Schuh Andrea Pellagatti Tudor A Fulga Amit Verma Jacqueline Boultwood

Oncotarget 2015 Dec;6(42):44061-71

Bloodwise Molecular Haematology Unit, Nuffield Division of Clinical Laboratory Sciences, Radcliffe Department of Medicine, University of Oxford and BRC Blood Theme, NIHR Oxford Biomedical Centre, Oxford University Hospital, Oxford, UK.

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http://dx.doi.org/10.18632/oncotarget.6392DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4792541PMC
December 2015

Reduced DOCK4 expression leads to erythroid dysplasia in myelodysplastic syndromes.

Authors:
Sriram Sundaravel Ryan Duggan Tushar Bhagat David L Ebenezer Hui Liu Yiting Yu Matthias Bartenstein Madhu Unnikrishnan Subhradip Karmakar Ting-Chun Liu Ingrid Torregroza Thomas Quenon John Anastasi Kathy L McGraw Andrea Pellagatti Jacqueline Boultwood Vijay Yajnik Andrew Artz Michelle M Le Beau Ulrich Steidl Alan F List Todd Evans Amit Verma Amittha Wickrema

Proc Natl Acad Sci U S A 2015 Nov 2;112(46):E6359-68. Epub 2015 Nov 2.

Department of Medicine, The University of Chicago, Chicago, IL 60637;

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http://dx.doi.org/10.1073/pnas.1516394112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4655581PMC
November 2015

CSNK1A1 mutations and gene expression analysis in myelodysplastic syndromes with del(5q).

Authors:
Erica Bello Andrea Pellagatti Jacqueline Shaw Cristina Mecucci Rajko Kušec Sally Killick Aristoteles Giagounidis Sophie Raynaud María J Calasanz Pierre Fenaux Jacqueline Boultwood

Br J Haematol 2015 Oct 18;171(2):210-214. Epub 2015 Jun 18.

LLR Molecular Haematology Unit, Nuffield Division of Clinical Laboratory Sciences, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1111/bjh.13563DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4744770PMC
October 2015

The molecular pathogenesis of the myelodysplastic syndromes.

Authors:
Andrea Pellagatti Jacqueline Boultwood

Eur J Haematol 2015 Jul 20;95(1):3-15. Epub 2015 Feb 20.

Leukaemia & Lymphoma Research Molecular Haematology Unit, Nuffield Division of Clinical Laboratory Sciences, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1111/ejh.12515DOI Listing
July 2015

Application of CRISPR/Cas9 genome editing to the study and treatment of disease.

Authors:
Andrea Pellagatti Hamid Dolatshad Simona Valletta Jacqueline Boultwood

Arch Toxicol 2015 Jul 1;89(7):1023-34. Epub 2015 Apr 1.

Leukaemia and Lymphoma Research Molecular Haematology Unit, Nuffield Division of Clinical Laboratory Sciences, Radcliffe Department of Medicine, and NIHR Biomedical Research Centre, Oxford University Hospitals, University of Oxford, Oxford, OX3 9DU, UK.

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http://dx.doi.org/10.1007/s00204-015-1504-yDOI Listing
July 2015

Recent Advances in the 5q- Syndrome.

Authors:
Andrea Pellagatti Jacqueline Boultwood

Mediterr J Hematol Infect Dis 2015 20;7(1):e2015037. Epub 2015 May 20.

Leukaemia & Lymphoma Research Molecular Haematology Unit, Nuffield Division of Clinical Laboratory Sciences, Radcliffe Department of Medicine, University of Oxford, and BRC Blood Theme, NIHR Oxford Biomedical Centre, Oxford University Hospitals, Oxford, United Kingdom.

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http://www.mjhid.org/index.php/mjhid/article/view/2015.037
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http://dx.doi.org/10.4084/MJHID.2015.037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4450650PMC
June 2015

IL8-CXCR2 pathway inhibition as a therapeutic strategy against MDS and AML stem cells.

Authors:
Carolina Schinke Orsolya Giricz Weijuan Li Aditi Shastri Shanisha Gordon Laura Barreyro Laura Barreryo Tushar Bhagat Sanchari Bhattacharyya Nandini Ramachandra Matthias Bartenstein Andrea Pellagatti Jacqueline Boultwood Amittha Wickrema Yiting Yu Britta Will Sheng Wei Ulrich Steidl Amit Verma

Blood 2015 May 25;125(20):3144-52. Epub 2015 Mar 25.

Division of Hemato-Oncology, Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, NY;

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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2015-01-62
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http://dx.doi.org/10.1182/blood-2015-01-621631DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4432009PMC
May 2015

Clinical associations of CSNK1A1 mutation in myelodysplastic syndrome.

Authors:
Jacqueline Boultwood Andrea Pellagatti

Lancet Haematol 2015 May 6;2(5):e182-3. Epub 2015 May 6.

Leukaemia and Lymphoma Research Molecular Haematology Unit, Nuffield Division of Clinical Laboratory Sciences, Radcliffe Department of Medicine, University of Oxford, John Radcliffe Hospital, Oxford, OX3 9DU, UK.

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http://dx.doi.org/10.1016/S2352-3026(15)00070-8DOI Listing
May 2015

Combining gene mutation with gene expression data improves outcome prediction in myelodysplastic syndromes.

Authors:
Moritz Gerstung Andrea Pellagatti Luca Malcovati Aristoteles Giagounidis Matteo G Della Porta Martin Jädersten Hamid Dolatshad Amit Verma Nicholas C P Cross Paresh Vyas Sally Killick Eva Hellström-Lindberg Mario Cazzola Elli Papaemmanuil Peter J Campbell Jacqueline Boultwood

Nat Commun 2015 Jan 9;6:5901. Epub 2015 Jan 9.

LLR Molecular Haematology Unit, NDCLS, RDM, University of Oxford, Oxford OX3 9DU, UK.

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http://dx.doi.org/10.1038/ncomms6901DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4338540PMC
January 2015

Aberrant overexpression of CD14 on granulocytes sensitizes the innate immune response in mDia1 heterozygous del(5q) MDS.

Authors:
Ganesan Keerthivasan Yang Mei Baobing Zhao Ling Zhang Chad E Harris Juehua Gao Ashley A Basiorka Matthew J Schipma James McElherne Jing Yang Amit K Verma Andrea Pellagatti Jacqueline Boultwood Alan F List David A Williams Peng Ji

Blood 2014 Jul 2;124(5):780-90. Epub 2014 Jun 2.

Department of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL;

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http://dx.doi.org/10.1182/blood-2014-01-552463DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4118486PMC
July 2014

Reduced translation of GATA1 in Diamond-Blackfan anemia.

Authors:
Jacqueline Boultwood Andrea Pellagatti

Nat Med 2014 Jul;20(7):703-4

Leukaemia & Lymphoma Research Molecular Haematology Unit, Nuffield Division of Clinical Laboratory Sciences, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1038/nm.3630DOI Listing
July 2014

Myelodysplastic syndromes are propagated by rare and distinct human cancer stem cells in vivo.

Authors:
Petter S Woll Una Kjällquist Onima Chowdhury Helen Doolittle David C Wedge Supat Thongjuea Rikard Erlandsson Mtakai Ngara Kristina Anderson Qiaolin Deng Adam J Mead Laura Stenson Alice Giustacchini Sara Duarte Eleni Giannoulatou Stephen Taylor Mohsen Karimi Christian Scharenberg Teresa Mortera-Blanco Iain C Macaulay Sally-Ann Clark Ingunn Dybedal Dag Josefsen Pierre Fenaux Peter Hokland Mette S Holm Mario Cazzola Luca Malcovati Sudhir Tauro David Bowen Jacqueline Boultwood Andrea Pellagatti John E Pimanda Ashwin Unnikrishnan Paresh Vyas Gudrun Göhring Brigitte Schlegelberger Magnus Tobiasson Gunnar Kvalheim Stefan N Constantinescu Claus Nerlov Lars Nilsson Peter J Campbell Rickard Sandberg Elli Papaemmanuil Eva Hellström-Lindberg Sten Linnarsson Sten Eirik W Jacobsen

Cancer Cell 2014 Jun 15;25(6):794-808. Epub 2014 May 15.

Haematopoietic Stem Cell Biology Laboratory, MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK; Departments of Cell and Molecular Biology, Medicine Huddinge, and Laboratory Medicine, Huddinge, Karolinska Institutet and Center for Hematology and Regenerative Medicine, Karolinska University Hospital Huddinge, 141 86 Stockholm, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.ccr.2014.03.036DOI Listing
June 2014

Identification of a BRCA1-mRNA splicing complex required for efficient DNA repair and maintenance of genomic stability.

Authors:
Kienan I Savage Julia J Gorski Eliana M Barros Gareth W Irwin Lorenzo Manti Alexander J Powell Andrea Pellagatti Natalia Lukashchuk Dennis J McCance W Glenn McCluggage Giuseppe Schettino Manuel Salto-Tellez Jacqueline Boultwood Derek J Richard Simon S McDade D Paul Harkin

Mol Cell 2014 May 17;54(3):445-59. Epub 2014 Apr 17.

Centre for Cancer Research and Cell Biology, Queen's University Belfast, 97 Lisburn Road, Belfast BT9 7BL, UK. Electronic address:

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http://www.cell.com/molecular-cell/pdf/S1097-2765(14)00253-6
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http://linkinghub.elsevier.com/retrieve/pii/S109727651400253
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http://dx.doi.org/10.1016/j.molcel.2014.03.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4017265PMC
May 2014

The role of splicing factor mutations in the pathogenesis of the myelodysplastic syndromes.

Authors:
Jacqueline Boultwood Hamid Dolatshad Satya S Varanasi Bon Ham Yip Andrea Pellagatti

Adv Biol Regul 2014 Jan 15;54:153-61. Epub 2013 Sep 15.

LLR Molecular Haematology Unit, Nuffield Division of Clinical Laboratory Sciences, Radcliffe Department of Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, United Kingdom.

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http://dx.doi.org/10.1016/j.jbior.2013.09.005DOI Listing
January 2014

Targeted re-sequencing analysis of 25 genes commonly mutated in myeloid disorders in del(5q) myelodysplastic syndromes.

Authors:
Marta Fernandez-Mercado Adam Burns Andrea Pellagatti Aristoteles Giagounidis Ulrich Germing Xabier Agirre Felipe Prosper Carlo Aul Sally Killick James S Wainscoat Anna Schuh Jacqueline Boultwood

Haematologica 2013 Dec 5;98(12):1856-64. Epub 2013 Jul 5.

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http://dx.doi.org/10.3324/haematol.2013.086686DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3856960PMC
December 2013

Clinical and biological implications of driver mutations in myelodysplastic syndromes.

Authors:
Elli Papaemmanuil Moritz Gerstung Luca Malcovati Sudhir Tauro Gunes Gundem Peter Van Loo Chris J Yoon Peter Ellis David C Wedge Andrea Pellagatti Adam Shlien Michael John Groves Simon A Forbes Keiran Raine Jon Hinton Laura J Mudie Stuart McLaren Claire Hardy Calli Latimer Matteo G Della Porta Sarah O'Meara Ilaria Ambaglio Anna Galli Adam P Butler Gunilla Walldin Jon W Teague Lynn Quek Alex Sternberg Carlo Gambacorti-Passerini Nicholas C P Cross Anthony R Green Jacqueline Boultwood Paresh Vyas Eva Hellstrom-Lindberg David Bowen Mario Cazzola Michael R Stratton Peter J Campbell

Blood 2013 Nov 12;122(22):3616-27; quiz 3699. Epub 2013 Sep 12.

Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton, United Kingdom;

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http://dx.doi.org/10.1182/blood-2013-08-518886DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3837510PMC
November 2013

Mutations in SETBP1 are recurrent in myelodysplastic syndromes and often coexist with cytogenetic markers associated with disease progression.

Authors:
Marta Fernandez-Mercado Andrea Pellagatti Cristina Di Genua Maria Jose Larrayoz Nils Winkelmann Paula Aranaz Adam Burns Anna Schuh Maria Jose Calasanz Nicholas C P Cross Jacqueline Boultwood

Br J Haematol 2013 Oct 24;163(2):235-9. Epub 2013 Jul 24.

LLR Molecular Haematology Unit, NDCLS, RDM, John Radcliffe Hospital, Oxford, UK.

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http://dx.doi.org/10.1111/bjh.12491DOI Listing
October 2013

The G-protein-coupled receptor CLR is upregulated in an autocrine loop with adrenomedullin in clear cell renal cell carcinoma and associated with poor prognosis.

Authors:
Leonid L Nikitenko Russell Leek Stephen Henderson Nischalan Pillay Helen Turley Daniele Generali Sarah Gunningham Helen R Morrin Andrea Pellagatti Margaret C P Rees Adrian L Harris Stephen B Fox

Clin Cancer Res 2013 Oct 22;19(20):5740-8. Epub 2013 Aug 22.

Authors' Affiliations: Cancer Research UK Viral Oncology Group and Sarcoma Biology Group, UCL Cancer Institute, University College London, London; Keble College, Linacre College, Nuffield Department of Clinical Laboratory Sciences; Cancer Research UK Oncology Laboratory, Weatherall Institute of Molecular Medicine; Nuffield Department of Obstetrics and Gynaecology, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom; Scientific Centre of the Family Health and Human Reproduction Problems, Siberian Branch of Russian Academy of Medical Sciences, Irkutsk, Russia; Unità di Patologia Mammaria Senologia e Breast, Unit Centro di Medicina Molecolare, Istituti Ospitalieri di Cremona, Cremona, Italy; Department of Pathology, Cancer Society Tissue Bank, University of Otago, Christchurch, New Zealand; Department of Pathology, University of Melbourne, Parkville; and Department of Pathology, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.

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http://dx.doi.org/10.1158/1078-0432.CCR-13-1712DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3836221PMC
October 2013

Identification of gene expression-based prognostic markers in the hematopoietic stem cells of patients with myelodysplastic syndromes.

Authors:
Andrea Pellagatti Axel Benner Ken I Mills Mario Cazzola Aristoteles Giagounidis Janet Perry Luca Malcovati Matteo G Della Porta Martin Jädersten Amit Verma Emma-Jane McDonald Sally Killick Eva Hellström-Lindberg Lars Bullinger James S Wainscoat Jacqueline Boultwood

J Clin Oncol 2013 Oct 3;31(28):3557-64. Epub 2013 Sep 3.

Andrea Pellagatti, Janet Perry, James S. Wainscoat, and Jacqueline Boultwood, University of Oxford, Oxford; Ken I. Mills, Queen's University Belfast, Belfast; Emma-Jane McDonald and Sally Killick, Royal Bournemouth Hospital, Bournemouth, United Kingdom; Axel Benner, German Cancer Research Center, Heidelberg; Aristoteles Giagounidis, St Johannes Hospital, Duisburg; Lars Bullinger, University Hospital of Ulm, Ulm, Germany; Mario Cazzola, Luca Malcovati, and Matteo G. Della Porta, Fondazione Istituto di Ricovera e Cura a Carattere Scientifico Policlinico San Matteo, Pavia, Italy; Martin Jädersten and Eva Hellström-Lindberg, Karolinska Institutet, Stockholm, Sweden; and Amit Verma, Albert Einstein College of Medicine, New York, NY.

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http://dx.doi.org/10.1200/JCO.2012.45.5626DOI Listing
October 2013

TP53 suppression promotes erythropoiesis in del(5q) MDS, suggesting a targeted therapeutic strategy in lenalidomide-resistant patients.

Authors:
Gisela Caceres Kathy McGraw Bon Ham Yip Andrea Pellagatti Joseph Johnson Ling Zhang Kenian Liu Lan Min Zhang William J Fulp Ji-Hyun Lee Najla H Al Ali Ashley Basiorka Larry J Smith F Joseph Daugherty Neil Littleton Richard A Wells Lubomir Sokol Sheng Wei Rami S Komrokji Jacqueline Boultwood Alan F List

Proc Natl Acad Sci U S A 2013 Oct 16;110(40):16127-32. Epub 2013 Sep 16.

H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612.

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http://dx.doi.org/10.1073/pnas.1311055110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3791697PMC
October 2013

High and low, but not intermediate, PRAME expression levels are poor prognostic markers in myelodysplastic syndrome at disease presentation.

Authors:
Fabio G Liberante Andrea Pellagatti Viktoriya Boncheva David T Bowen Ken I Mills Jacqueline Boultwood Barbara-Ann Guinn

Br J Haematol 2013 Jul 18;162(2):282-5. Epub 2013 Apr 18.

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http://dx.doi.org/10.1111/bjh.12352DOI Listing
July 2013

Mutation patterns of 16 genes in primary and secondary acute myeloid leukemia (AML) with normal cytogenetics.

Authors:
Marta Fernandez-Mercado Bon Ham Yip Andrea Pellagatti Carwyn Davies María José Larrayoz Toshinori Kondo Cristina Pérez Sally Killick Emma-Jane McDonald María Dolores Odero Xabier Agirre Felipe Prósper María José Calasanz James S Wainscoat Jacqueline Boultwood

PLoS One 2012 9;7(8):e42334. Epub 2012 Aug 9.

LLR Molecular Haematology Unit, NDCLS, John Radcliffe Hospital, Oxford, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0042334PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3415392PMC
April 2013

miR-21 mediates hematopoietic suppression in MDS by activating TGF-β signaling.

Authors:
Tushar D Bhagat Li Zhou Lubomir Sokol Rachel Kessel Gisela Caceres Krishna Gundabolu Roni Tamari Shanisha Gordon Ioannis Mantzaris Tomasz Jodlowski Yiting Yu Xiaohong Jing Rahul Polineni Kavi Bhatia Andrea Pellagatti Jacqueline Boultwood Suman Kambhampati Ulrich Steidl Cy Stein Wenjun Ju Gang Liu Paraic Kenny Alan List Markus Bitzer Amit Verma

Blood 2013 Apr 6;121(15):2875-81. Epub 2013 Feb 6.

Albert Einstein College of Medicine, Bronx, NY;

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http://dx.doi.org/10.1182/blood-2011-12-397067DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3624935PMC
April 2013

Silencing of ASXL1 impairs the granulomonocytic lineage potential of human CD34⁺ progenitor cells.

Authors:
Carwyn Davies Bon Ham Yip Marta Fernandez-Mercado Petter S Woll Xabier Agirre Felipe Prosper Sten E Jacobsen James S Wainscoat Andrea Pellagatti Jacqueline Boultwood

Br J Haematol 2013 Mar 8;160(6):842-50. Epub 2013 Jan 8.

LLR Molecular Haematology Unit, NDCLS, John Radcliffe Hospital, Oxford, UK.

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http://dx.doi.org/10.1111/bjh.12217DOI Listing
March 2013

Activation of the mTOR pathway by the amino acid (L)-leucine in the 5q- syndrome and other ribosomopathies.

Authors:
Jacqueline Boultwood Bon Ham Yip Chaitanya Vuppusetty Andrea Pellagatti James S Wainscoat

Adv Biol Regul 2013 Jan 13;53(1):8-17. Epub 2012 Sep 13.

LLR Molecular Haematology Unit, NDCLS, John Radcliffe Hospital, Oxford, UK.

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http://dx.doi.org/10.1016/j.jbior.2012.09.002DOI Listing
January 2013

5q- syndrome.

Authors:
Jacqueline Boultwood Andrea Pellagatti James S Wainscoat

Curr Pharm Des 2012 ;18(22):3180-3

LLR Molecular Haematology Unit, NDCLS, John Radcliffe Hospital, Oxford, UK.

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http://dx.doi.org/10.2174/1381612811209023180DOI Listing
October 2012

Stem and progenitor cells in myelodysplastic syndromes show aberrant stage-specific expansion and harbor genetic and epigenetic alterations.

Authors:
Britta Will Li Zhou Thomas O Vogler Susanna Ben-Neriah Carolina Schinke Roni Tamari Yiting Yu Tushar D Bhagat Sanchari Bhattacharyya Laura Barreyro Christoph Heuck Yonkai Mo Samir Parekh Christine McMahon Andrea Pellagatti Jacqueline Boultwood Cristina Montagna Lewis Silverman Jaroslaw Maciejewski John M Greally B Hilda Ye Alan F List Christian Steidl Ulrich Steidl Amit Verma

Blood 2012 Sep 2;120(10):2076-86. Epub 2012 Jul 2.

Albert Einstein College of Medicine, Bronx, NY, USA.

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http://dx.doi.org/10.1182/blood-2011-12-399683DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3437595PMC
September 2012

Overexpression of IL-1 receptor accessory protein in stem and progenitor cells and outcome correlation in AML and MDS.

Authors:
Laura Barreyro Britta Will Boris Bartholdy Li Zhou Tihomira I Todorova Robert F Stanley Susana Ben-Neriah Cristina Montagna Samir Parekh Andrea Pellagatti Jacqueline Boultwood Elisabeth Paietta Rhett P Ketterling Larry Cripe Hugo F Fernandez Peter L Greenberg Martin S Tallman Christian Steidl Constantine S Mitsiades Amit Verma Ulrich Steidl

Blood 2012 Aug 21;120(6):1290-8. Epub 2012 Jun 21.

Department of Cell Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.

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http://dx.doi.org/10.1182/blood-2012-01-404699DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3418722PMC
August 2012

Loss of heterozygosity in 7q myeloid disorders: clinical associations and genomic pathogenesis.

Authors:
Andres Jerez Yuka Sugimoto Hideki Makishima Amit Verma Anna M Jankowska Bartlomiej Przychodzen Valeria Visconte Ramon V Tiu Christine L O'Keefe Azim M Mohamedali Austin G Kulasekararaj Andrea Pellagatti Kathy McGraw Hideki Muramatsu Alison R Moliterno Mikkael A Sekeres Michael A McDevitt Seiji Kojima Alan List Jacqueline Boultwood Ghulam J Mufti Jaroslaw P Maciejewski

Blood 2012 Jun 2;119(25):6109-17. Epub 2012 May 2.

Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH, USA.

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http://dx.doi.org/10.1182/blood-2011-12-397620DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3383019PMC
June 2012

Haploinsufficiency of ribosomal proteins and p53 activation in anemia: Diamond-Blackfan anemia and the 5q- syndrome.

Authors:
Jacqueline Boultwood Andrea Pellagatti James S Wainscoat

Adv Biol Regul 2012 Jan;52(1):196-203

LLR Molecular Haematology Unit, NDCLS, John Radcliffe Hospital, Oxford OX3 9DU, UK.

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https://linkinghub.elsevier.com/retrieve/pii/S00652571110005
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http://dx.doi.org/10.1016/j.advenzreg.2011.09.008DOI Listing
January 2012

Marked down-regulation of nucleophosmin-1 is associated with advanced del(5q) myelodysplastic syndrome.

Authors:
Andrea Pellagatti Mario Cazzola Aristoteles Giagounidis Janet Perry Luca Malcovati Matteo G Della Porta Martin Jädersten Sally Killick Paresh Vyas Eva Hellström-Lindberg James S Wainscoat Jacqueline Boultwood

Br J Haematol 2011 Oct 15;155(2):272-4. Epub 2011 Apr 15.

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http://dx.doi.org/10.1111/j.1365-2141.2011.08672.xDOI Listing
October 2011

Aberrant epigenetic and genetic marks are seen in myelodysplastic leukocytes and reveal Dock4 as a candidate pathogenic gene on chromosome 7q.

Authors:
Li Zhou Joanna Opalinska Davendra Sohal Yiting Yu Yongkai Mo Tushar Bhagat Omar Abdel-Wahab Melissa Fazzari Maria Figueroa Cristina Alencar Jinghang Zhang Suman Kambhampati Simrit Parmar Sangeeta Nischal Christoph Hueck Masako Suzuki Ellen Freidman Andrea Pellagatti Jacqueline Boultwood Ulrich Steidl Yogen Sauthararajah Vijay Yajnik Christine McMahon Steven D Gore Leonidas C Platanias Ross Levine Ari Melnick Amittha Wickrema John M Greally Amit Verma

J Biol Chem 2011 Jul 30;286(28):25211-23. Epub 2011 Apr 30.

Albert Einstein College of Medicine, Bronx, New York 10461, USA.

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http://dx.doi.org/10.1074/jbc.M111.235028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3137092PMC
July 2011

Reduced SMAD7 leads to overactivation of TGF-beta signaling in MDS that can be reversed by a specific inhibitor of TGF-beta receptor I kinase.

Authors:
Li Zhou Christine McMahon Tushar Bhagat Cristina Alencar Yiting Yu Melissa Fazzari Davendra Sohal Christoph Heuck Krishna Gundabolu Chun Ng Yongkai Mo Wa Shen Amittha Wickrema Guanghui Kong Ellen Friedman Lubomir Sokol Ioannis Mantzaris Giannis Mantzaris Andrea Pellagatti Jacqueline Boultwood Leonidas C Platanias Ulrich Steidl Lei Yan Jonathan M Yingling Michael M Lahn Alan List Markus Bitzer Amit Verma

Cancer Res 2011 Feb 28;71(3):955-63. Epub 2010 Dec 28.

Albert Einstein College of Medicine, Bronx, New York 10461, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-10-2933DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3032816PMC
February 2011

Advances in the 5q- syndrome.

Authors:
Jacqueline Boultwood Andrea Pellagatti Andrew N J McKenzie James S Wainscoat

Blood 2010 Dec 23;116(26):5803-11. Epub 2010 Aug 23.

Leukaemia & Lymphoma Research Molecular Haematology Unit, Nuffield Department of Clinical Laboratory Sciences, John Radcliffe Hospital, Headington, Oxford, United Kingdom.

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http://dx.doi.org/10.1182/blood-2010-04-273771DOI Listing
December 2010

Gene expression profiling of erythroblasts from refractory anaemia with ring sideroblasts (RARS) and effects of G-CSF.

Authors:
Maryam Nikpour Andrea Pellagatti Anquan Liu Mohsen Karimi Luca Malcovati Vladimir Gogvadze Ann-Mari Forsblom James S Wainscoat Mario Cazzola Boris Zhivotovsky Alf Grandien Jacqueline Boultwood Eva Hellström-Lindberg

Br J Haematol 2010 Jun 12;149(6):844-54. Epub 2010 Apr 12.

Centre of Experimental Haematology, Department of Medicine (Huddinge), Karolinska Institute, Stockholm, Sweden.

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http://dx.doi.org/10.1111/j.1365-2141.2010.08174.xDOI Listing
June 2010

Induction of p53 and up-regulation of the p53 pathway in the human 5q- syndrome.

Authors:
Andrea Pellagatti Teresa Marafioti Jennifer C Paterson Jillian L Barlow Lesley F Drynan Aristoteles Giagounidis Stefano A Pileri Mario Cazzola Andrew N J McKenzie James S Wainscoat Jacqueline Boultwood

Blood 2010 Apr;115(13):2721-3

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http://dx.doi.org/10.1182/blood-2009-12-259705DOI Listing
April 2010

Clonal heterogeneity in the 5q- syndrome: p53 expressing progenitors prevail during lenalidomide treatment and expand at disease progression.

Authors:
Martin Jädersten Leonie Saft Andrea Pellagatti Gudrun Göhring James S Wainscoat Jacqueline Boultwood Anna Porwit Brigitte Schlegelberger Eva Hellström-Lindberg

Haematologica 2009 Dec 1;94(12):1762-6. Epub 2009 Oct 1.

Karolinska Institutet, Department of Medicine, Center for Experimental Hematology, Karolinska University Hospital, Stockholm, Sweden.

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http://dx.doi.org/10.3324/haematol.2009.011528DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2791931PMC
December 2009

Molecular and clinical features of refractory anemia with ringed sideroblasts associated with marked thrombocytosis.

Authors:
Luca Malcovati Matteo G Della Porta Daniela Pietra Emanuela Boveri Andrea Pellagatti Anna Gallì Erica Travaglino Angela Brisci Elisa Rumi Francesco Passamonti Rosangela Invernizzi Laura Cremonesi Jacqueline Boultwood James S Wainscoat Eva Hellström-Lindberg Mario Cazzola

Blood 2009 Oct 19;114(17):3538-45. Epub 2009 Aug 19.

Department of Hematology Oncology, University of Pavia & Fondazione Istituto Di Ricovero e Cura a Carattere Scientifico (IRCCS), Policlinico San Matteo, Pavia, Italy.

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http://dx.doi.org/10.1182/blood-2009-05-222331DOI Listing
October 2009

Marked downregulation of the granulopoiesis regulator LEF1 is associated with disease progression in the myelodysplastic syndromes.

Authors:
Andrea Pellagatti Teresa Marafioti Jennifer C Paterson Luca Malcovati Matteo G Della Porta Martin Jädersten Beena Pushkaran Tracy I George Daniel A Arber Sally Killick Aristoteles Giagounidis Eva Hellström-Lindberg Mario Cazzola James S Wainscoat Jacqueline Boultwood

Br J Haematol 2009 Jun 5;146(1):86-90. Epub 2009 May 5.

LRF Molecular Haematology Unit, NDCLS, John Radcliffe Hospital, Oxford, UK.

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http://dx.doi.org/10.1111/j.1365-2141.2009.07720.xDOI Listing
June 2009

Inhibition of the TGF-beta receptor I kinase promotes hematopoiesis in MDS.

Authors:
Li Zhou Aaron N Nguyen Davendra Sohal Jing Ying Ma Perry Pahanish Krishna Gundabolu Josh Hayman Adam Chubak Yongkai Mo Tushar D Bhagat Bhaskar Das Ann M Kapoun Tony A Navas Simrit Parmar Suman Kambhampati Andrea Pellagatti Ira Braunchweig Ying Zhang Amittha Wickrema Satyanarayana Medicherla Jacqueline Boultwood Leonidas C Platanias Linda S Higgins Alan F List Markus Bitzer Amit Verma

Blood 2008 Oct 12;112(8):3434-43. Epub 2008 May 12.

Albert Einstein College of Medicine, Bronx, NY, USA.

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http://dx.doi.org/10.1182/blood-2008-02-139824DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2569182PMC
October 2008

Meta-analysis of microarray studies reveals a novel hematopoietic progenitor cell signature and demonstrates feasibility of inter-platform data integration.

Authors:
Davendra Sohal Andrew Yeatts Kenny Ye Andrea Pellagatti Li Zhou Perry Pahanish Yongkai Mo Tushar Bhagat John Mariadason Jacqueline Boultwood Ari Melnick John Greally Amit Verma

PLoS One 2008 Aug 13;3(8):e2965. Epub 2008 Aug 13.

Albert Einstein College of Medicine, Bronx, New York, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0002965PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2495035PMC
August 2008

Haploinsufficiency of RPS14 in 5q- syndrome is associated with deregulation of ribosomal- and translation-related genes.

Authors:
Andrea Pellagatti Eva Hellström-Lindberg Aristoteles Giagounidis Janet Perry Luca Malcovati Matteo G Della Porta Martin Jädersten Sally Killick Carrie Fidler Mario Cazzola James S Wainscoat Jacqueline Boultwood

Br J Haematol 2008 Jul 8;142(1):57-64. Epub 2008 May 8.

LRF Molecular Haematology Unit, NDCLS, John Radcliffe Hospital, Oxford, UK.

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http://dx.doi.org/10.1111/j.1365-2141.2008.07178.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2440427PMC
July 2008

The role of the iron transporter ABCB7 in refractory anemia with ring sideroblasts.

Authors:
Jacqueline Boultwood Andrea Pellagatti Maryam Nikpour Beena Pushkaran Carrie Fidler Helen Cattan Tim J Littlewood Luca Malcovati Matteo G Della Porta Martin Jädersten Sally Killick Aristoteles Giagounidis David Bowen Eva Hellström-Lindberg Mario Cazzola James S Wainscoat

PLoS One 2008 Apr 9;3(4):e1970. Epub 2008 Apr 9.

LRF Molecular Haematology Unit, Nuffield Department of Clinical Laboratory Sciences, John Radcliffe Hospital, Oxford, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0001970PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2276313PMC
April 2008

Gene expression profiling of CD34+ cells in patients with the 5q- syndrome.

Authors:
Jacqueline Boultwood Andrea Pellagatti Helen Cattan Charles H Lawrie Aristoteles Giagounidis Luca Malcovati Matteo G Della Porta Martin Jädersten Sally Killick Carrie Fidler Mario Cazzola Eva Hellström-Lindberg James S Wainscoat

Br J Haematol 2007 Nov 3;139(4):578-89. Epub 2007 Oct 3.

LRF Molecular Haematology Unit, NDCLS, John Radcliffe Hospital, Oxford, UK.

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http://dx.doi.org/10.1111/j.1365-2141.2007.06833.xDOI Listing
November 2007

Lenalidomide inhibits the malignant clone and up-regulates the SPARC gene mapping to the commonly deleted region in 5q- syndrome patients.

Authors:
Andrea Pellagatti Martin Jädersten Ann-Mari Forsblom Helen Cattan Birger Christensson Emma K Emanuelsson Mats Merup Lars Nilsson Jan Samuelsson Birgitta Sander James S Wainscoat Jacqueline Boultwood Eva Hellström-Lindberg

Proc Natl Acad Sci U S A 2007 Jul 18;104(27):11406-11. Epub 2007 Jun 18.

Leukaemia Research Fund Molecular Haematology Unit, Nuffield Department of Clinical Laboratory Sciences, John Radcliffe Hospital, Oxford OX3 9DU, United Kingdom.

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http://dx.doi.org/10.1073/pnas.0610477104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1892786PMC
July 2007

Gene expression profiles of CD34+ cells in myelodysplastic syndromes: involvement of interferon-stimulated genes and correlation to FAB subtype and karyotype.

Authors:
Andrea Pellagatti Mario Cazzola Aristoteles A N Giagounidis Luca Malcovati Matteo G Della Porta Sally Killick Lisa J Campbell Li Wang Cordelia F Langford Carrie Fidler David Oscier Carlo Aul James S Wainscoat Jacqueline Boultwood

Blood 2006 Jul 9;108(1):337-45. Epub 2006 Mar 9.

Leukaemia Research Fund (LRF) Molecular Haematology Unit, Nuffield Department of Clinical Laboratory Sciences (NDCLS), John Radcliffe Hospital, Oxford OX3 9DU, United Kingdom.

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http://dx.doi.org/10.1182/blood-2005-12-4769DOI Listing
July 2006

Gene expression profiling in the myelodysplastic syndromes.

Authors:
Andrea Pellagatti Carrie Fidler James S Wainscoat Jacqueline Boultwood

Hematology 2005 Aug;10(4):281-7

Leukaemia Research Fund Molecular Haematology Unit, Nuffield Department of Clinical Laboratory Sciences, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK.

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http://dx.doi.org/10.1080/10245330500065680DOI Listing
August 2005

Low expression of the putative tumour suppressor gene gravin in chronic myeloid leukaemia, myelodysplastic syndromes and acute myeloid leukaemia.

Authors:
Jacqueline Boultwood Andrea Pellagatti Fiona Watkins Lisa J Campbell Noor Esoof Nicholas C P Cross Helen Eagleton Tim J Littlewood Carrie Fidler James S Wainscoat

Br J Haematol 2004 Aug;126(4):508-11

Leukaemia Research Fund Molecular Haematology Unit, Nuffield Department of Clinical Laboratory Sciences, John Radcliffe Hospital, Oxford, UK.

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http://doi.wiley.com/10.1111/j.1365-2141.2004.05067.x
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http://dx.doi.org/10.1111/j.1365-2141.2004.05067.xDOI Listing
August 2004

Gene expression profiling in the myelodysplastic syndromes using cDNA microarray technology.

Authors:
Andrea Pellagatti Noor Esoof Fiona Watkins Cordelia F Langford David Vetrie Lisa J Campbell Carrie Fidler James D Cavenagh Helen Eagleton Peter Gordon Barrie Woodcock Beena Pushkaran Mark Kwan James S Wainscoat Jacqueline Boultwood

Br J Haematol 2004 Jun;125(5):576-83

Leukaemia Research Fund Molecular Haematology Unit, Nuffield Department of Clinical Laboratory Sciences, John Radcliffe Hospital, Oxford, UK.

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http://dx.doi.org/10.1111/j.1365-2141.2004.04958.xDOI Listing
June 2004

Identification of acquired somatic mutations in the gene encoding chromatin-remodeling factor ATRX in the alpha-thalassemia myelodysplasia syndrome (ATMDS).

Authors:
Richard J Gibbons Andrea Pellagatti David Garrick William G Wood Nicola Malik Helena Ayyub Cordelia Langford Jacqueline Boultwood James S Wainscoat Douglas R Higgs

Nat Genet 2003 Aug;34(4):446-9

MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, OX3 9DS UK.

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http://dx.doi.org/10.1038/ng1213DOI Listing
August 2003

Gene expression profiling in polycythemia vera using cDNA microarray technology.

Authors:
Andrea Pellagatti David Vetrie Cordelia F Langford Susana Gama Helen Eagleton James S Wainscoat Jacqueline Boultwood

Cancer Res 2003 Jul;63(14):3940-4

Leukaemia Research Fund, Molecular Haematology Unit, Nuffield Department of Clinical Laboratory Sciences, John Radcliffe Hospital, Oxford OX3 9DU, United Kingdom.

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July 2003