Andrea Ilari

Institute of Molecular Biology and Pathology, Italian National Research Council (IBPM-CNR), c/o Department of Biochemical Sciences "A. Rossi Fanelli", Sapienza University of Rome, P.le A. Moro 5, 00185 Rome, Italy. Electronic address:

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January 2021

Sorcin is an early marker of neurodegeneration, Ca dysregulation and endoplasmic reticulum stress associated to neurodegenerative diseases.

Cell Death Dis 2020 10 15;11(10):861. Epub 2020 Oct 15.

Institute of Molecular Biology and Pathology, Italian National Research Council, IBPM-CNR, Rome, Italy.

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October 2020

Spiro-containing derivatives show antiparasitic activity against Trypanosoma brucei through inhibition of the trypanothione reductase enzyme.

Authors:

Lorenzo Turcano Theo Battista Esther Torrente De Haro Antonino Missineo Cristina Alli Giacomo Paonessa Gianni Colotti Steven Harper Annarita Fiorillo Andrea Ilari Alberto Bresciani

PLoS Negl Trop Dis 2020 05 21;14(5):e0008339. Epub 2020 May 21.

Department of Translational and Discovery Research, Pomezia (Roma) Italy.

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May 2020

Targeting Trypanothione Reductase, a Key Enzyme in the Redox Trypanosomatid Metabolism, to Develop New Drugs against Leishmaniasis and Trypanosomiases.

Authors:

Theo Battista Gianni Colotti Andrea Ilari Annarita Fiorillo

Molecules 2020 Apr 21;25(8). Epub 2020 Apr 21.

Department of Biochemical Sciences, Sapienza University, P. le A. Moro 5, 00185 Rome, Italy.

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April 2020

Profiling calcium-dependent interactions between Sorcin and intrinsically disordered regions of human proteome.

Authors:

Ilaria Genovese Andrea Carotti Andrea Ilari Annarita Fiorillo Theo Battista Gianni Colotti Ylva Ivarsson

Biochim Biophys Acta Gen Subj 2020 08 17;1864(8):129618. Epub 2020 Apr 17.

Department of Chemistry - BMC, Uppsala University, Husargatan 3, 751 23 Uppsala, Sweden.

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August 2020

Roles of Sorcin in Drug Resistance in Cancer: One Protein, Many Mechanisms, for a Novel Potential Anticancer Drug Target.

Authors:

Theo Battista Annarita Fiorillo Valerio Chiarini Ilaria Genovese Andrea Ilari Gianni Colotti

Cancers (Basel) 2020 Apr 6;12(4). Epub 2020 Apr 6.

Institute of Molecular Biology and Pathology, Italian National Research Council, Istituto di Biologia e Patologia Molecolari, Consiglio Nazionale delle Ricerche (IBPM-CNR), c/o Department of Biochemical Sciences, Sapienza University, P.le A.Moro 5, 00185 Rome, Italy.

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April 2020

Bioinformatics analysis of Ras homologue enriched in the striatum, a potential target for Huntington's disease therapy.

Authors:

Miriam Carbo Valentina Brandi Gianmarco Pascarella David Sasah Staid Gianni Colotti Fabio Polticelli Andrea Ilari Veronica Morea

Int J Mol Med 2019 Dec 15;44(6):2223-2233. Epub 2019 Oct 15.

Institute of Molecular Biology and Pathology of The National Research Council of Italy, I‑00185 Rome, Italy.

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December 2019

Structure-guided approach to identify a novel class of anti-leishmaniasis diaryl sulfide compounds targeting the trypanothione metabolism.

Authors:

Gianni Colotti Francesco Saccoliti Marina Gramiccia Trentina Di Muccio Jay Prakash Sunita Yadav Vikash Kumar Dubey Giulio Vistoli Theo Battista Stefano Mocci Annarita Fiorillo Aasia Bibi Valentina Noemi Madia Antonella Messore Roberta Costi Roberto Di Santo Andrea Ilari

Amino Acids 2020 Feb 29;52(2):247-259. Epub 2019 Apr 29.

Istituto di Biologia e Patologia Molecolari, Consiglio Nazionale delle Ricerche, IBPM-CNR, c/o Dip. Scienze Biochimiche Università Sapienza, P.le Aldo Moro 5, 00185, Rome, Italy.

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February 2020

Identification and binding mode of a novel Leishmania Trypanothione reductase inhibitor from high throughput screening.

Authors:

Lorenzo Turcano Esther Torrente Antonino Missineo Matteo Andreini Marina Gramiccia Trentina Di Muccio Ilaria Genovese Annarita Fiorillo Steven Harper Alberto Bresciani Gianni Colotti Andrea Ilari

PLoS Negl Trop Dis 2018 11 26;12(11):e0006969. Epub 2018 Nov 26.

Istituto di Biologia e Patologia Molecolari-CNR, and Dipartimento di Scienze Biochimiche, "Sapienza" Università di Roma P.le A. Moro, Roma, Italy.

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November 2018

Engineered ferritin for lanthanide binding.

Authors:

Lorenzo Calisti Matilde Cardoso Trabuco Alberto Boffi Claudia Testi Linda Celeste Montemiglio Amédée des Georges Irene Benni Andrea Ilari Bartłomiej Taciak Maciej Białasek Tomasz Rygiel Magdalena Król Paola Baiocco Alessandra Bonamore

PLoS One 2018 13;13(8):e0201859. Epub 2018 Aug 13.

Department of Biochemical Sciences "Alessandro Rossi Fanelli", Sapienza University of Rome, Rome Italy.

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February 2019

The phosphoglycerate kinase 1 variants found in carcinoma cells display different catalytic activity and conformational stability compared to the native enzyme.

Authors:

Annarita Fiorillo Maria Petrosino Andrea Ilari Alessandra Pasquo Alessandra Cipollone Maristella Maggi Roberta Chiaraluce Valerio Consalvi

PLoS One 2018 11;13(7):e0199191. Epub 2018 Jul 11.

Department of Biochemical Sciences "A. Rossi Fanelli", Sapienza University of Rome, Rome, Italy.

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December 2018

Toward a Drug Against All Kinetoplastids: From LeishBox to Specific and Potent Trypanothione Reductase Inhibitors.

Authors:

Andrea Ilari Ilaria Genovese Fabiana Fiorillo Theo Battista Ilenia De Ionna Annarita Fiorillo Gianni Colotti

Mol Pharm 2018 08 27;15(8):3069-3078. Epub 2018 Jun 27.

Institute of Molecular Biology and Pathology, Italian National Research Council (IBPM CNR), Department of Biochemical Sciences , Sapienza University , P.le A. Moro 5 , 00185 Rome , Italy.

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August 2018

Identification of chalcone-based antileishmanial agents targeting trypanothione reductase.

Authors:

Margherita Ortalli Andrea Ilari Gianni Colotti Ilenia De Ionna Theo Battista Alessandra Bisi Silvia Gobbi Angela Rampa Rita M C Di Martino Giovanna A Gentilomi Stefania Varani Federica Belluti

Eur J Med Chem 2018 May 2;152:527-541. Epub 2018 May 2.

Department of Pharmacy and Biotechnology, Alma Mater Studiorum University of Bologna, Bologna, Italy. Electronic address:

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May 2018

Generation of induced pluripotent stem cell line, CSSi004-A (2962), from a patient diagnosed with Huntington's disease at the presymptomatic stage.

Authors:

Eris Bidollari Giovannina Rotundo Daniela Ferrari Ornella Candido Laura Bernardini Federica Consoli Alessandro De Luca Iolanda Santimone Giuseppe Lamorte Andrea Ilari Ferdinando Squitieri Angelo Luigi Vescovi Jessica Rosati

Stem Cell Res 2018 04 21;28:145-148. Epub 2018 Feb 21.

IRCCS Casa Sollievo della Sofferenza, Cellular Reprogramming Unit, Viale dei Cappuccini, 71013 San Giovanni Rotondo, Foggia, Italy. Electronic address:

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April 2018

Study of manganese binding to the ferroxidase centre of human H-type ferritin.

Authors:

Matteo Ardini Barry D Howes Annarita Fiorillo Elisabetta Falvo Silvia Sottini Donella Rovai Marco Lantieri Andrea Ilari Dante Gatteschi Gabriele Spina Emilia Chiancone Simonetta Stefanini Maria Fittipaldi

J Inorg Biochem 2018 05 9;182:103-112. Epub 2018 Feb 9.

INSTM, Department of Physics and Astronomy, University of Florence, Via Sansone 1, 50019 Sesto Fiorentino, Florence, Italy. Electronic address:

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May 2018

Not only P-glycoprotein: Amplification of the ABCB1-containing chromosome region 7q21 confers multidrug resistance upon cancer cells by coordinated overexpression of an assortment of resistance-related proteins.

Authors:

Ilaria Genovese Andrea Ilari Yehuda G Assaraf Francesco Fazi Gianni Colotti

Drug Resist Updat 2017 05 16;32:23-46. Epub 2017 Oct 16.

Institute of Molecular Biology and Pathology, Italian National Research Council (IBPM-CNR), c/o Dept. Biochemical Sciences, Sapienza University, P.le A. Moro 5, 00185 Rome, Italy. Electronic address:

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May 2017

Metal- and metalloid-containing drugs for the treatment of trypanosomatid diseases.

Authors:

Gianni Colotti Annarita Fiorillo Andrea Ilari

Front Biosci (Landmark Ed) 2018 Jan 1;23:954-966. Epub 2018 Jan 1.

CNR-Institute of Molecular Biology and Pathology, c/o Department of Biochemical Sciences, Sapienza University of Rome, P.le A. Moro 5, 00185 Roma, Italy,

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January 2018

Binding of doxorubicin to Sorcin impairs cell death and increases drug resistance in cancer cells.

Authors:

Ilaria Genovese Annarita Fiorillo Andrea Ilari Silvia Masciarelli Francesco Fazi Gianni Colotti

Cell Death Dis 2017 07 20;8(7):e2950. Epub 2017 Jul 20.

IBPM-CNR Institute of Molecular Biology and Pathology, Italian National Research Council, Rome, Italy.

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July 2017

A novel antimicrobial approach based on the inhibition of zinc uptake in Salmonella enterica.

Authors:

Andrea Battistoni Serena Ammendola Emilia Chiancone Andrea Ilari

Future Med Chem 2017 06 21;9(9):899-910. Epub 2017 Jun 21.

Consiglio Nazionale delle Ricerche (CNR)-Istituto di Biologia e Patologia Molecolari (IBPM) c/o Dipartimento di Scienze Biochimiche, Università Sapienza di Roma, P.le Aldo Moro 5, 00185 Rome, Italy.

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June 2017

Structural characterization of Giardia duodenalis thioredoxin reductase (gTrxR) and computational analysis of its interaction with NBDHEX.

Authors:

Simone Brogi Annarita Fiorillo Giulia Chemi Stefania Butini Marco Lalle Andrea Ilari Sandra Gemma Giuseppe Campiani

Eur J Med Chem 2017 Jul 24;135:479-490. Epub 2017 Apr 24.

European Research Centre for Drug Discovery and Development (NatSynDrugs), Department of Biotechnology, Chemistry, and Pharmacy, Università di Siena via Aldo Moro 2, 53100 Siena, Italy.

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July 2017

Glucose transportation in the brain and its impairment in Huntington disease: one more shade of the energetic metabolism failure?

Authors:

Veronica Morea Eris Bidollari Gianni Colotti Annarita Fiorillo Jessica Rosati Lidia De Filippis Ferdinando Squitieri Andrea Ilari

Amino Acids 2017 07 10;49(7):1147-1157. Epub 2017 Apr 10.

National Research Council of Italy (CNR), Institute of Molecular Biology and Pathology c/o Department of Biochemical Sciences, Sapienza University of Rome, P.le A. Moro 5, 00185, Rome, Italy.

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July 2017

Inhibition of Leishmania infantum trypanothione reductase by diaryl sulfide derivatives.

Authors:

Francesco Saccoliti Gabriella Angiulli Giovanni Pupo Luca Pescatori Valentina Noemi Madia Antonella Messore Gianni Colotti Annarita Fiorillo Luigi Scipione Marina Gramiccia Trentina Di Muccio Roberto Di Santo Roberta Costi Andrea Ilari

J Enzyme Inhib Med Chem 2017 Dec;32(1):304-310

b Istituto di Biologia e Patologia Molecolari - CNR , and Dipartimento di Scienze Biochimiche , " Sapienza" Università di Roma , Roma , Italia.

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December 2017

Polyamine-trypanothione pathway: an update.

Authors:

Andrea Ilari Annarita Fiorillo Ilaria Genovese Gianni Colotti

Future Med Chem 2017 01 13;9(1):61-77. Epub 2016 Dec 13.

CNR - National Research Council of Italy, Institute of Molecular Biology & Pathology, c/o Department of Biochemical Sciences "A. Rossi Fanelli", University Sapienza, P.le Aldo Moro 5, 00185 - Rome, Italy.

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January 2017

A Practical Approach to Protein Crystallography.

Authors:

Andrea Ilari Carmelinda Savino

Methods Mol Biol 2017 ;1525:47-78

C.N.R.-Istituto di Biologia e Patologia Molecolari c/o Dipartimento di Scienze Biochimiche "A. Rossi Fanelli", Università "Sapienza", P.le Aldo Moro, 5, 00185, Rome, Italy.

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January 2018