Publications by authors named "Andrea Gambotto"

56Publications

Impact of checkpoint blockade on cancer vaccine-activated CD8+ T cell responses.

J Exp Med 2020 Jul;217(7)

University of Pittsburgh Medical Center, Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA.

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http://dx.doi.org/10.1084/jem.20191369DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7336310PMC
July 2020

Improved Cutaneous Genetic Immunization by Microneedle Array Delivery of an Adjuvanted Adenovirus Vaccine.

J Invest Dermatol 2020 Apr 21. Epub 2020 Apr 21.

Department of Dermatology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA; Department of Bioengineering, University of Pittsburgh Swanson School of Engineering, Pittsburgh, Pennsylvania, USA; Clinical and Translational Science Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, USA; The UPMC Hillman Cancer Center, Pittsburgh, Pennsylvania, USA; The McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jid.2020.03.966DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7172852PMC
April 2020

Microneedle array delivered recombinant coronavirus vaccines: Immunogenicity and rapid translational development.

EBioMedicine 2020 May 2;55:102743. Epub 2020 Apr 2.

Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, W1148 Biomedical Science Tower, 200 Lothrop St., Pennsylvania, PA 15213, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ebiom.2020.102743DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7128973PMC
May 2020

Multiple antigen-engineered DC vaccines with or without IFNα to promote antitumor immunity in melanoma.

J Immunother Cancer 2019 04 24;7(1):113. Epub 2019 Apr 24.

Department of Medicine, University of Pittsburgh, UPMC Hillman Cancer Center, 5117 Centre Avenue, Suite 1.27, Pittsburgh, PA, 15213, USA.

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http://dx.doi.org/10.1186/s40425-019-0552-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6480917PMC
April 2019

Contrasting Roles of the PD-1 Signaling Pathway in Dendritic Cell-Mediated Induction and Regulation of HIV-1-Specific Effector T Cell Functions.

J Virol 2019 03 19;93(5). Epub 2019 Feb 19.

Department of Infectious Diseases and Microbiology, University of Pittsburgh Graduate School of Public Health, Pittsburgh, Pennsylvania, USA.

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http://dx.doi.org/10.1128/JVI.02035-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6384070PMC
March 2019

Preventative Vaccines for Zika Virus Outbreak: Preliminary Evaluation.

EBioMedicine 2016 Nov 3;13:315-320. Epub 2016 Oct 3.

Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA; Department of Molecular Genetics and Biochemistry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA; Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ebiom.2016.09.028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5264651PMC
November 2016

Enhanced Cytotoxic CD8 T Cell Priming Using Dendritic Cell-Expressing Human Papillomavirus-16 E6/E7-p16INK4 Fusion Protein with Sequenced Anti-Programmed Death-1.

J Immunol 2016 Mar 5;196(6):2870-8. Epub 2016 Feb 5.

Department of Otolaryngology, University of Pittsburgh, Pittsburgh, PA 15232; Department of Immunology, University of Pittsburgh, Pittsburgh, PA 15232; and Cancer Immunology Program, University of Pittsburgh Cancer Institute, Pittsburgh, PA 15213

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http://dx.doi.org/10.4049/jimmunol.1502027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4779745PMC
March 2016

IL-Y, a synthetic member of the IL-12 cytokine family, suppresses the development of type 1 diabetes in NOD mice.

Eur J Immunol 2015 Nov 1;45(11):3114-25. Epub 2015 Sep 1.

Department of Metabolism and Aging, The Scripps Research Institute, Jupiter, FL, USA.

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http://dx.doi.org/10.1002/eji.201445403DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4823813PMC
November 2015

Immunogenicity of an adenoviral-based Middle East Respiratory Syndrome coronavirus vaccine in BALB/c mice.

Vaccine 2014 Oct 3;32(45):5975-82. Epub 2014 Sep 3.

Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15224, USA. Electronic address:

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http://dx.doi.org/10.1016/j.vaccine.2014.08.058DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7115510PMC
October 2014

Intranasal vaccination with replication-defective adenovirus type 5 encoding influenza virus hemagglutinin elicits protective immunity to homologous challenge and partial protection to heterologous challenge in pigs.

Clin Vaccine Immunol 2012 Nov 29;19(11):1722-9. Epub 2012 Aug 29.

Virus and Prion Research Unit, National Animal Disease Center, United States Department of Agriculture-Agricultural Research Service, Ames, Iowa, USA.

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http://dx.doi.org/10.1128/CVI.00315-12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3491537PMC
November 2012

A candidate H1N1 pandemic influenza vaccine elicits protective immunity in mice.

PLoS One 2010 May 5;5(5):e10492. Epub 2010 May 5.

Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0010492PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2864737PMC
May 2010

Biochemical isolation and characterization of the tubulovesicular LC3-positive autophagosomal compartment.

J Biol Chem 2010 Jan 12;285(2):1371-83. Epub 2009 Nov 12.

Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA.

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http://dx.doi.org/10.1074/jbc.M109.054197DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2801263PMC
January 2010

Adenovirus 5- and 35-based immunotherapy enhances the strength but not breadth or quality of immunity during chronic SIV infection.

Eur J Immunol 2009 Sep;39(9):2437-49

Department of Infectious Diseases, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA.

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http://doi.wiley.com/10.1002/eji.200839130
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http://dx.doi.org/10.1002/eji.200839130DOI Listing
September 2009

Human infection with highly pathogenic H5N1 influenza virus.

Lancet 2008 Apr;371(9622):1464-75

Department of Surgery, Division of Infectious Diseases, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15219, USA.

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http://dx.doi.org/10.1016/S0140-6736(08)60627-3DOI Listing
April 2008

Efficacy of topical immunoglobulins against experimental adenoviral ocular infection.

Invest Ophthalmol Vis Sci 2007 Sep;48(9):4171-6

Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15219, USA.

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http://dx.doi.org/10.1167/iovs.07-0491DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2039928PMC
September 2007

Immunomodulation by adenoviral-mediated SCD40-Ig gene therapy for mouse allogeneic islet transplantation.

Transplantation 2007 Aug;84(3):301-7

Department of Molecular Genetics and Biochemistry, University of Pittsburgh School of Medicine Pittsburgh, PA 15261, USA.

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https://insights.ovid.com/crossref?an=00007890-200708150-000
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http://dx.doi.org/10.1097/01.tp.0000275183.50435.b6DOI Listing
August 2007

Essential role of the TNF-TNFR2 cognate interaction in mouse dendritic cell-natural killer cell crosstalk.

Blood 2007 Apr 12;109(8):3333-41. Epub 2006 Dec 12.

University of Pittsburgh Cancer Institute, Hillman Cancer Center, 5117 Centre Avenue, Pittsburgh, PA, USA.

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http://dx.doi.org/10.1182/blood-2006-06-026385DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1852244PMC
April 2007

Bid-independent mitochondrial activation in tumor necrosis factor alpha-induced apoptosis and liver injury.

Mol Cell Biol 2007 Jan 13;27(2):541-53. Epub 2006 Nov 13.

Department of Pathology, University of Pittsburgh School of Medicine, Scaife Hall, 7th Floor, Room S739, 3550 Terrace Street, Pittsburgh, PA 15261, USA.

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http://dx.doi.org/10.1128/MCB.01166-06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1800794PMC
January 2007

Adoptive transfer of type 1 CTL mediates effective anti-central nervous system tumor response: critical roles of IFN-inducible protein-10.

Cancer Res 2006 Apr;66(8):4478-87

Department of Neurological Surgery, University of Pittsburgh Cancer Institute, Pennsylvania 15213, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-05-3825DOI Listing
April 2006

Evidence of the capability of the CMV enhancer to activate in trans gene expression in mammalian cells.

DNA Cell Biol 2006 Mar;25(3):171-80

Department of Surgery, Division of Infectious Diseases, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15219, USA.

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http://dx.doi.org/10.1089/dna.2006.25.171DOI Listing
March 2006

Protection of mice and poultry from lethal H5N1 avian influenza virus through adenovirus-based immunization.

J Virol 2006 Feb;80(4):1959-64

Department of Surgery and Medicine, University of Pittsburgh School of Medicine, Molecular Medicine Institute, Suite 412, 300 Technology Drive, Pittsburgh, PA 15219, USA.

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http://dx.doi.org/10.1128/JVI.80.4.1959-1964.2006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1367171PMC
February 2006

Exosomes derived from IL-10-treated dendritic cells can suppress inflammation and collagen-induced arthritis.

J Immunol 2005 May;174(10):6440-8

Department of Molecular Genetics and Biochemistry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.

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http://dx.doi.org/10.4049/jimmunol.174.10.6440DOI Listing
May 2005

Adenovirus-mediated XIAP gene transfer reverses the negative effects of immunosuppressive drugs on insulin secretion and cell viability of isolated human islets.

Diabetes 2005 Feb;54(2):424-33

Division of Endocrinology & Diabetes and Metabolism, Department of Medicine, Cedars-Sinai Medical Center, 8723 Alden Dr., SSB #290, Los Angeles, CA 90048, USA.

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http://diabetes.diabetesjournals.org/content/54/2/424.full.p
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http://dx.doi.org/10.2337/diabetes.54.2.424DOI Listing
February 2005

UpGene: Application of a web-based DNA codon optimization algorithm.

Biotechnol Prog 2004 Mar-Apr;20(2):443-8

Department of Molecular Genetics and Biochemistry and Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.

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http://dx.doi.org/10.1021/bp0300467DOI Listing
December 2004

IRF-1 expression induces apoptosis and inhibits tumor growth in mouse mammary cancer cells in vitro and in vivo.

Oncogene 2004 Feb;23(5):1125-35

Department of Surgery, University of Pittsburgh Medical Center, 497 Scaife Hall, 3550 Terrace Street, Pittsburgh, PA 15261, USA.

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http://dx.doi.org/10.1038/sj.onc.1207023DOI Listing
February 2004

Effects of a SARS-associated coronavirus vaccine in monkeys.

Lancet 2003 Dec;362(9399):1895-6

Department of Surgery Molecular, Division of Infectious Diseases, University of Pittsburgh School of Medicine, Pittsburgh, PA 15219, USA.

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http://dx.doi.org/10.1016/S0140-6736(03)14962-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7112457PMC
December 2003

Adenovirus-transduced dendritic cells injected into skin or lymph node prime potent simian immunodeficiency virus-specific T cell immunity in monkeys.

J Immunol 2003 Dec;171(12):6875-82

Department of Infectious Diseases and Microbiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA.

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http://dx.doi.org/10.4049/jimmunol.171.12.6875DOI Listing
December 2003

Intratumoral delivery of dendritic cells engineered to secrete both interleukin (IL)-12 and IL-18 effectively treats local and distant disease in association with broadly reactive Tc1-type immunity.

Cancer Res 2003 Oct;63(19):6378-86

Department of Surgery, University of Pittsburgh School of Medicine, The Hillman Cancer Center, 5117 Center Avenue, Pittsburgh, PA 15213, USA.

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October 2003

Dendritic cells transduced to express interleukin-4 prevent diabetes in nonobese diabetic mice with advanced insulitis.

Hum Gene Ther 2003 Jan;14(1):13-23

Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.

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http://dx.doi.org/10.1089/10430340360464679DOI Listing
January 2003

Local administration of IL-12-transfected dendritic cells induces antitumor immune responses to colon adenocarcinoma in the liver in mice.

J Exp Ther Oncol 2002 Nov-Dec;2(6):337-49

Biologic Therapeutics Program, University of Pittsburgh Cancer Institute, 5725 CHP-MT, 200 Lothrop Street, Pittsburgh, PA 15213, USA.

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http://dx.doi.org/10.1046/j.1359-4117.2002.01050.xDOI Listing
April 2003

Increased function and survival of IL-15-transduced human dendritic cells are mediated by up-regulation of IL-15Ralpha and Bcl-2.

J Leukoc Biol 2002 Nov;72(5):1037-45

Department of Pathology, University of Pittsburgh Medical Center and University of Pittsburgh Cancer Institute, Pennsylvania 15213, USA.

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November 2002

Interleukin 18 gene transfer expands the repertoire of antitumor Th1-type immunity elicited by dendritic cell-based vaccines in association with enhanced therapeutic efficacy.

Cancer Res 2002 Oct;62(20):5853-8

Department of Surgery, University of Pittsburgh School of Medicine, Pennsylvania 15261, USA.

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October 2002

Role of NF-kappaB on liver cold ischemia-reperfusion injury.

Am J Physiol Gastrointest Liver Physiol 2002 Nov;283(5):G1175-84

Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA.

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http://dx.doi.org/10.1152/ajpgi.00515.2001DOI Listing
November 2002

Hepatocyte Fas-associating death domain protein/mediator of receptor-induced toxicity (FADD/MORT1) levels increase in response to pro-apoptotic stimuli.

J Biol Chem 2002 Oct 6;277(41):38855-62. Epub 2002 Aug 6.

Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA.

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http://dx.doi.org/10.1074/jbc.M203484200DOI Listing
October 2002

Human tumor-derived genomic DNA transduced into a recipient cell induces tumor-specific immune responses ex vivo.

Proc Natl Acad Sci U S A 2002 Jul 21;99(14):9415-20. Epub 2002 Jun 21.

Department of Pathology, University of Pittsburgh School of Medicine and University of Pittsburgh Cancer Institute, Pittsburgh, PA 15213, USA.

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http://dx.doi.org/10.1073/pnas.142302399DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC123155PMC
July 2002