Andrea Gaedigk

Andrea Gaedigk

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Andrea Gaedigk

Publications by authors named "Andrea Gaedigk"

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PharmVar GeneFocus: CYP2D6.

Clin Pharmacol Ther 2020 Jan 9;107(1):154-170. Epub 2019 Dec 9.

Division of Clinical Pharmacology, Toxicology, & Therapeutic Innovation, Children's Mercy Kansas City, Kansas City, Missouri, USA.

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https://onlinelibrary.wiley.com/doi/abs/10.1002/cpt.1643
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http://dx.doi.org/10.1002/cpt.1643DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6925641PMC
January 2020

PharmVar and the Landscape of Pharmacogenetic Resources.

Clin Pharmacol Ther 2020 Jan 23;107(1):43-46. Epub 2019 Nov 23.

Department of Biomedical Data Science, Stanford University, Stanford, California, USA.

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http://dx.doi.org/10.1002/cpt.1654DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6925620PMC
January 2020

Normalized Testosterone Glucuronide as a Potential Urinary Biomarker for Highly Variable UGT2B17 in Children 7-18 Years.

Clin Pharmacol Ther 2020 Jan 3. Epub 2020 Jan 3.

Department of Pharmaceutics, University of Washington, Seattle, Washington, USA.

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http://dx.doi.org/10.1002/cpt.1764DOI Listing
January 2020

Impact of SLCO1B1 genetic variation on rosuvastatin systemic exposure in pediatric hypercholesterolemia.

Clin Transl Sci 2020 Jan 25. Epub 2020 Jan 25.

Division of Clinical Pharmacology, Toxicology and Therapeutic Innovation, Children's Mercy, Kansas City, MO.

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http://dx.doi.org/10.1111/cts.12749DOI Listing
January 2020

Pharmacogene Variation in Thai Relapse Patients Treated with a Combination of Primaquine and Chloroquine.

Pharmgenomics Pers Med 2020 10;13:1-12. Epub 2020 Jan 10.

Division of Pharmacogenomics and Personalized Medicine, Department of Pathology, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.

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http://dx.doi.org/10.2147/PGPM.S201007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6966953PMC
January 2020

Structural variation at the CYP2C locus: Characterization of deletion and duplication alleles.

Hum Mutat 2019 11;40(11):e37-e51

Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York.

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http://dx.doi.org/10.1002/humu.23855DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6810756PMC
November 2019

Characterization of Reference Materials for Genetic Testing of CYP2D6 Alleles: A GeT-RM Collaborative Project.

J Mol Diagn 2019 Nov 9;21(6):1034-1052. Epub 2019 Aug 9.

Informatics and Data Science Branch, Division of Laboratory Systems, Office of Surveillance, Epidemiology, and Laboratory Services, Centers for Disease Control and Prevention, Atlanta, Georgia. Electronic address:

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http://dx.doi.org/10.1016/j.jmoldx.2019.06.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6854474PMC
November 2019

Ontogeny of Hepatic Sulfotransferases and Prediction of Age-Dependent Fractional Contribution of Sulfation in Acetaminophen Metabolism.

Drug Metab Dispos 2019 08 17;47(8):818-831. Epub 2019 May 17.

Department of Pharmaceutical Analysis, National Institute of Pharmaceutical Education and Research (NIPER), Mohali, Punjab, India (M.K.L., S.Sh., A.T., S.Si.); Department of Pharmaceutics, University of Washington, Seattle, Washington (D.K.B., B.P.); Division of Clinical Pharmacology, Toxicology & Therapeutic Innovation, Department of Pediatrics, Children's Mercy Kansas City, Kansas City, Missouri (A.G., R.E.P., J.S.L.); School of Medicine, University of Missouri-Kansas City, Kansas City, Missouri (A.G., R.E.P., J.S.L.); and Simulations Plus, Inc., Lancaster, California (M.B.B.)

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http://dmd.aspetjournals.org/lookup/doi/10.1124/dmd.119.0864
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http://dx.doi.org/10.1124/dmd.119.086462DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6614793PMC
August 2019

Pharmacogenetics: Chasing Perfection.

Authors:
Andrea Gaedigk

Clin Pharmacol Ther 2019 Aug;106(2):265-270

Division of Clinical Pharmacology, Toxicology, and Therapeutic Innovation, Children's Mercy Kansas City, Kansas City, Missouri, USA.

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http://dx.doi.org/10.1002/cpt.1511DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6668915PMC
August 2019

Clinical Pharmacogenetics Implementation Consortium Guideline for Cytochrome P450 (CYP)2D6 Genotype and Atomoxetine Therapy.

Clin Pharmacol Ther 2019 Jul 13;106(1):94-102. Epub 2019 Apr 13.

Division of Clinical Pharmacology, Toxicology & Therapeutic Innovation, Department of Pediatrics, Children's Mercy Kansas City, Kansas City, Missouri, USA.

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http://dx.doi.org/10.1002/cpt.1409DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6612570PMC
July 2019

The Case for Pharmacogenetics-Guided Prescribing of Codeine in Children.

Clin Pharmacol Ther 2019 Jun 22;105(6):1300-1302. Epub 2018 Nov 22.

Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.

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http://dx.doi.org/10.1002/cpt.1260DOI Listing
June 2019

Impact of Genetic Variation on Pravastatin Systemic Exposure in Pediatric Hypercholesterolemia.

Clin Pharmacol Ther 2019 Jun 25;105(6):1501-1512. Epub 2019 Feb 25.

Division of Clinical Pharmacology, Medical Toxicology and Therapeutic Innovation, Children's Mercy, Kansas City, Missouri, USA.

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http://dx.doi.org/10.1002/cpt.1330DOI Listing
June 2019

Pharmacogene Variation Consortium Gene Introduction: NUDT15.

Clin Pharmacol Ther 2019 05 4;105(5):1091-1094. Epub 2018 Dec 4.

School of Medicine, University of Missouri-Kansas City, Kansas City, Missouri, USA.

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http://dx.doi.org/10.1002/cpt.1268DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6465081PMC
May 2019

CYP2C9*61, a rare missense variant identified in a Puerto Rican patient with low warfarin dose requirements.

Pharmacogenomics 2019 01 6;20(1):3-8. Epub 2018 Dec 6.

Department of Pharmaceutical Sciences, School of Pharmacy, Medical Sciences Campus, University of Puerto Rico, San Juan, PR 00936, Puerto Rico.

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http://dx.doi.org/10.2217/pgs-2018-0143DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6479273PMC
January 2019

The Evolution of PharmVar.

Clin Pharmacol Ther 2019 01 7;105(1):29-32. Epub 2018 Dec 7.

School of Medicine, University of Missouri-Kansas City, Kansas City, Missouri, USA.

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https://onlinelibrary.wiley.com/doi/abs/10.1002/cpt.1275
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http://dx.doi.org/10.1002/cpt.1275DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6312487PMC
January 2019

Integrated CYP2D6 interrogation for multiethnic copy number and tandem allele detection.

Pharmacogenomics 2019 01 6;20(1):9-20. Epub 2018 Dec 6.

Department of Genetics & Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.

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http://dx.doi.org/10.2217/pgs-2018-0135DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6563015PMC
January 2019

CYP2D6 genotype analysis of a Thai population: platform comparison.

Pharmacogenomics 2018 08 11;19(12):947-960. Epub 2018 Jul 11.

Division of Pharmacogenomics and Personalized Medicine, Department of Pathology, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok 10400, Thailand.

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http://dx.doi.org/10.2217/pgs-2018-0075DOI Listing
August 2018

Variants in the CYP2B6 3'UTR Alter In Vitro and In Vivo CYP2B6 Activity: Potential Role of MicroRNAs.

Clin Pharmacol Ther 2018 07 25;104(1):130-138. Epub 2017 Oct 25.

Department of Medicine, Division of Clinical Pharmacology, Indiana University School of Medicine, Indianapolis, Indiana, USA.

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http://dx.doi.org/10.1002/cpt.892DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5871545PMC
July 2018

Impact of SLCO1B1 Genotype on Pediatric Simvastatin Acid Pharmacokinetics.

J Clin Pharmacol 2018 06 22;58(6):823-833. Epub 2018 Feb 22.

Division of Clinical Pharmacology, Medical Toxicology and Therapeutic Innovation, Children's Mercy, Kansas City, MO, USA.

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http://dx.doi.org/10.1002/jcph.1080DOI Listing
June 2018

Hepatic Abundance and Activity of Androgen- and Drug-Metabolizing Enzyme UGT2B17 Are Associated with Genotype, Age, and Sex.

Drug Metab Dispos 2018 06 30;46(6):888-896. Epub 2018 Mar 30.

Departments of Pharmaceutics (D.K.B., A.B., H.Z., K.G.C., A.M., B.P.), Genome Sciences (S.L., D.A.N.), Biostatistics (T.A.T.), and Medicine (J.K.A.), University of Washington, Seattle, Washington; Division of Pediatric Pharmacology and Medical Toxicology, Department of Pediatrics, Children's Mercy Hospitals and Clinics, Kansas City, Missouri (A.G., R.E.P., R.G., J.S.L.); Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee (A.S.C., E.G.S.); and Section of Genomic Pediatrics, Department of Pediatrics, and Human and Molecular Genetics Center, Medical College of Wisconsin, Milwaukee, Wisconsin (U.B.)

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http://dx.doi.org/10.1124/dmd.118.080952DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5938891PMC
June 2018

PASSPORT-seq: A Novel High-Throughput Bioassay to Functionally Test Polymorphisms in Micro-RNA Target Sites.

Front Genet 2018 15;9:219. Epub 2018 Jun 15.

Division of Clinical Pharmacology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, United States.

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http://dx.doi.org/10.3389/fgene.2018.00219DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6013768PMC
June 2018

Ten Years' Experience with the CYP2D6 Activity Score: A Perspective on Future Investigations to Improve Clinical Predictions for Precision Therapeutics.

J Pers Med 2018 Apr 17;8(2). Epub 2018 Apr 17.

Division of Clinical Pharmacology, Toxicology & Therapeutic Innovation, Children's Mercy Kansas City, 2401 Gillham Rd, Kanas City, MO 64108, USA.

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http://dx.doi.org/10.3390/jpm8020015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6023391PMC
April 2018

Pharmacogenomic Variability of Oral Baclofen Clearance and Clinical Response in Children With Cerebral Palsy.

PM R 2018 03 1;10(3):235-243. Epub 2017 Sep 1.

Division of Rehabilitation Medicine, Children's Mercy-Kansas City, 2401 Gillham Road, Kansas City, MO 64108; Division of Clinical Pharmacology, Toxicology and Therapeutic Innovation, Children's Mercy, Kansas City, MO.

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http://dx.doi.org/10.1016/j.pmrj.2017.08.441DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5880219PMC
March 2018

Impact of CYP2D6 on venlafaxine metabolism in Trinidadian patients with major depressive disorder.

Pharmacogenomics 2018 02 12;19(3):197-212. Epub 2018 Jan 12.

Division of Clinical Pharmacology, Toxicology & Therapeutic Innovation, Children's Mercy Kansas City & Department of Pediatrics, School of Medicine, University of Missouri-Kansas City, Kansas City, MO 64108, USA.

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https://www.futuremedicine.com/doi/10.2217/pgs-2017-0142
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http://dx.doi.org/10.2217/pgs-2017-0142DOI Listing
February 2018

Precision medicine: does ethnicity information complement genotype-based prescribing decisions?

Ther Adv Drug Saf 2018 Jan 1;9(1):45-62. Epub 2017 Dec 1.

Director, Pharmacogenetics Core Laboratory, Clinical Pharmacology, Toxicology & Therapeutic Innovation, Children's Mercy-Kansas City, Kansas City, MO and School of Medicine, University of Missouri-Kansas City, MO, USA.

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http://dx.doi.org/10.1177/2042098617743393DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5753996PMC
January 2018

Genetic and Nongenetic Factors Associated with Protein Abundance of Flavin-Containing Monooxygenase 3 in Human Liver.

J Pharmacol Exp Ther 2017 11 17;363(2):265-274. Epub 2017 Aug 17.

Departments of Pharmaceutics (M.X., D.K.B., K.G.C., K.E.T., B.P.), Medicinal Chemistry (C.K.Y., A.E.R.), and Genome Sciences (D.N.), University of Washington, Seattle, Washington; Department of Clinical Pharmacology, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China (M.X.); Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee (A.S.C., E.S.); Division of Pediatric Pharmacology and Medical Toxicology, Department of Pediatrics, Children's Mercy Hospitals and Clinics, Kansas City, Missouri (A.G., R.E.P., R.G., J.S.L.); and Section of Genomic Pediatrics, Department of Pediatrics, and Human and Molecular Genetics Center, Medical College of Wisconsin, Milwaukee, Wisconsin (U.B.)

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http://jpet.aspetjournals.org/lookup/doi/10.1124/jpet.117.24
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http://dx.doi.org/10.1124/jpet.117.243113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5697103PMC
November 2017

Age-dependent Protein Abundance of Cytosolic Alcohol and Aldehyde Dehydrogenases in Human Liver.

Drug Metab Dispos 2017 09 12;45(9):1044-1048. Epub 2017 Jun 12.

Department of Pharmaceutics, University of Washington, Seattle, Washington (D.K.B., B.P.); Department of Clinical Pharmacology, Toxicology & Therapeutic Innovation, Children's Mercy-Kansas City, Missouri and School of Medicine, University of Missouri-Kansas City, Kansas City, Missouri (A.G., R.E.P., J.S.L.)

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http://dx.doi.org/10.1124/dmd.117.076463DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5563927PMC
September 2017

In vivo characterization of CYP2D6*12, *29 and *84 using dextromethorphan as a probe drug: a case report.

Pharmacogenomics 2017 Apr 14;18(5):427-431. Epub 2017 Mar 14.

Center for Pediatric Genomic Medicine, Children's Mercy Kansas City, Kansas City, MO 64108, USA.

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http://dx.doi.org/10.2217/pgs-2016-0192DOI Listing
April 2017

Impact of CYP2D6 genotype on amitriptyline efficacy for the treatment of diabetic peripheral neuropathy: a pilot study.

Pharmacogenomics 2017 Apr 28;18(5):433-443. Epub 2017 Mar 28.

Department of Immunology & the Institute for Cellular & Molecular Medicine, South African Medical Research Council Extramural Unit for Stem Cell Research & Therapy, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa.

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http://dx.doi.org/10.2217/pgs-2016-0185DOI Listing
April 2017

Age-Dependent Absolute Abundance of Hepatic Carboxylesterases (CES1 and CES2) by LC-MS/MS Proteomics: Application to PBPK Modeling of Oseltamivir In Vivo Pharmacokinetics in Infants.

Drug Metab Dispos 2017 02 28;45(2):216-223. Epub 2016 Nov 28.

Department of Pharmaceutics, University of Washington, Seattle, Washington (M.B., M.V., A.M., D.K.B., B.P.); Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden (M.B.); Division of Clinical Pharmacology, Toxicology, and Therapeutic Innovation, Children's Mercy Kansas City, Kansas City, Missouri (R.E.P., A.G., J.S.L.); and School of Medicine, University of Missouri-Kansas City, Kansas City, Missouri (R.E.P., A.G., J.S.L.)

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http://dx.doi.org/10.1124/dmd.116.072652DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5267516PMC
February 2017

Prediction of CYP2D6 phenotype from genotype across world populations.

Genet Med 2017 01 7;19(1):69-76. Epub 2016 Jul 7.

Division of Clinical Pharmacology, Toxicology & Therapeutic Innovation, Children's Mercy-Kansas City, Kansas City, Missouri, USA.

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http://dx.doi.org/10.1038/gim.2016.80DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5292679PMC
January 2017

Pharmacogenetics to prevent maniac affective switching with treatment for bipolar disorder: CYP2D6.

Pharmacogenomics 2016 08 29;17(12):1291-3. Epub 2016 Jul 29.

IBSAL, Salamanca Institute for Biomedical Research, Salamanca, Spain.

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http://dx.doi.org/10.2217/pgs-2016-0105DOI Listing
August 2016

Developmental Expression of CYP2B6: A Comprehensive Analysis of mRNA Expression, Protein Content and Bupropion Hydroxylase Activity and the Impact of Genetic Variation.

Drug Metab Dispos 2016 07 25;44(7):948-58. Epub 2015 Nov 25.

Division of Clinical Pharmacology, Toxicology and Therapeutic Innovation (R.E.P., R.G., G.P.T., A.K.R., J.S.L., A.G.), and Health Services and Outcomes Research (H.D.), Children's Mercy Kansas City, Kansas City, Missouri; and Department of Pediatrics, School of Medicine, University of Missouri-Kansas City, Kansas City, Missouri (R.E.P., R.G., H.D., J.S.L., A.G.).

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http://dx.doi.org/10.1124/dmd.115.067546DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4931886PMC
July 2016

Characterization of Atomoxetine Biotransformation and Implications for Development of PBPK Models for Dose Individualization in Children.

Drug Metab Dispos 2016 07 6;44(7):1070-9. Epub 2016 Apr 6.

Division of Clinical Pharmacology, Toxicology, and Therapeutic Innovation (J.C.D., L.V.H., R.E.P., A.G., J.S.L.), Department of Pediatrics, Children's Mercy Hospital (L.V.H., R.E.P., A.G., J.S.L.), University of Kansas Medical Center (J.S.L.), and Department of Pharmacology (A.G., R.E.P., J.S.L.), University of Missouri-Kansas City, Kansas City, Missouri.

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http://dx.doi.org/10.1124/dmd.116.069518DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4931890PMC
July 2016

Prediction of Warfarin Dose in Pediatric Patients: An Evaluation of the Predictive Performance of Several Models.

J Pediatr Pharmacol Ther 2016 May-Jun;21(3):224-32

Section of Pharmacology & Toxicology, University of Arkansas for Medical Sciences/Arkansas Children's Hospital, Little Rock, Arkansas.

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http://dx.doi.org/10.5863/1551-6776-21.3.224DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4956330PMC
July 2016

Rifampin Regulation of Drug Transporters Gene Expression and the Association of MicroRNAs in Human Hepatocytes.

Front Pharmacol 2016 26;7:111. Epub 2016 Apr 26.

Division of Clinical Pharmacology, Department of Medicine, Indiana University School of Medicine Indianapolis, IN, USA.

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http://dx.doi.org/10.3389/fphar.2016.00111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4845040PMC
May 2016

Long-Read Single Molecule Real-Time Full Gene Sequencing of Cytochrome P450-2D6.

Hum Mutat 2016 Mar 18;37(3):315-23. Epub 2015 Dec 18.

Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, 10029.

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http://dx.doi.org/10.1002/humu.22936DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4752389PMC
March 2016

CYP450 genotype and pharmacogenetic association studies: a critical appraisal.

Pharmacogenomics 2016 Feb 18;17(3):259-75. Epub 2016 Jan 18.

Department of Surgery & Cancer, Faculty of Medicine, Imperial College, South Kensington Campus, London, UK.

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http://dx.doi.org/10.2217/pgs.15.172DOI Listing
February 2016

Role of Pharmacogenetics in Improving the Safety of Psychiatric Care by Predicting the Potential Risks of Mania in CYP2D6 Poor Metabolizers Diagnosed With Bipolar Disorder.

Medicine (Baltimore) 2016 Feb;95(6):e2473

From the Servicio de Psiquiatría, Hospital Universitario de Salamanca (SS-I, CL-R, TM-P); Instituto Biosanitario de Salamanca, IBSAL (VG-S, BG-B, AS-M, JML-R, MI-G); Servicio de Bioquímica Clínica, Hospital Universitario de Salamanca (BG-B, JMG-B, MI-G); Servicio de Farmacia, Hospital Universitario de Salamanca, Spain (AS-M); Division of Clinical Pharmacology, Toxicology and Therapeutic Innovation, Children's Mercy Hospital (AG); Department of Pediatrics, School of Medicine, University of Missouri-Kansas City, Kansas City, MO, USA (AG); and Departamento de Medicina, Universidad de Salamanca, Spain (MI-G).

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http://dx.doi.org/10.1097/MD.0000000000002473DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4753865PMC
February 2016

CYP2D7 Sequence Variation Interferes with TaqMan CYP2D6 (*) 15 and (*) 35 Genotyping.

Front Pharmacol 2015 12;6:312. Epub 2016 Jan 12.

Division of Clinical Pharmacology, Toxicology and Therapeutic Innovation, Children's Mercy Kansas CityKansas City, MO, USA; School of Medicine, University of Missouri-Kansas CityKansas City, MO, USA.

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http://dx.doi.org/10.3389/fphar.2015.00312DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4709848PMC
January 2016

CYP2D6 Haplotype Determination Using Long Range Allele-Specific Amplification: Resolution of a Complex Genotype and a Discordant Genotype Involving the CYP2D6*59 Allele.

J Mol Diagn 2015 Nov 1;17(6):740-8. Epub 2015 Sep 1.

Division of Clinical Pharmacology, Toxicology and Therapeutic Innovation, Children's Mercy Kansas City, Kansas City, Missouri; Department of Pediatrics, University of Missouri-Kansas City, Kansas City, Missouri.

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http://dx.doi.org/10.1016/j.jmoldx.2015.06.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4630174PMC
November 2015

SNP genotyping using TaqMan technology: the CYP2D6*17 assay conundrum.

Sci Rep 2015 Mar 19;5:9257. Epub 2015 Mar 19.

1] Division of Clinical Pharmacology, Toxicology &Therapeutic Innovation, Children's Mercy Kansas City, Kansas City, MO [2] Department of Pediatrics, University of Missouri-Kansas City, Kansas City, MO.

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http://dx.doi.org/10.1038/srep09257DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4365394PMC
March 2015

Effect of CYP3A5 genotype, steroids, and azoles on tacrolimus in a pediatric renal transplant population.

Pediatr Nephrol 2014 Oct 30;29(10):2039-49. Epub 2014 May 30.

Division of Nephrology, Children's Mercy Hospital, University of Missouri-Kansas City, 2401 Gilham Road, Kansas City, MO, 64108, USA,

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http://dx.doi.org/10.1007/s00467-014-2827-2DOI Listing
October 2014

CYP2D6 and pharmacogenomics: where does future research need to focus? Part 2: clinical aspects.

Pharmacogenomics 2014 Jun;15(8):1055-8

Division of Clinical Pharmacology, Toxicology & Therapeutic Innovation, Department of Pediatrics, Children's Mercy Kansas City & University of Missouri-Kansas City, 2401 Gillham Rd, Kansas City, MO 64108, USA.

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https://www.futuremedicine.com/doi/10.2217/pgs.14.27
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http://dx.doi.org/10.2217/pgs.14.27DOI Listing
June 2014

Resolution of a clinical AmpliChip CYP450 Test™ no call: discovery and characterization of novel CYP2D6*1 haplotypes.

Pharmacogenomics 2014 Jun;15(9):1175-84

Division of Clinical Pharmacology, Toxicology & Therapeutic Innovation, Children's Mercy Hospital, 2401 Gilham Road, Kansas City, MO 64108, USA.

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http://dx.doi.org/10.2217/pgs.14.94DOI Listing
June 2014

CYP2D6 and pharmacogenomics: where does future research need to focus? Part 1: technical aspects.

Pharmacogenomics 2014 Mar;15(4):407-10

Division of Clinical Pharmacology & Therapeutic Innovation, Children's Mercy Hospital & Clinics & Department of Pediatrics, University of Missouri-Kansas City, 2401 Gillham Road, Kansas City, MO 64108, USA.

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http://dx.doi.org/10.2217/pgs.14.28DOI Listing
March 2014

Challenges in CYP2D6 phenotype assignment from genotype data: a critical assessment and call for standardization.

Curr Drug Metab 2014 Feb;15(2):218-32

Clinical Pharmacology & Therapeutic Innovation, Children's Mercy Hospital, 2401 Gillham Rd, Kansas City, MO 64108, USA.

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http://dx.doi.org/10.2174/1389200215666140202215316DOI Listing
February 2014

Regulation of microRNA expression by rifampin in human hepatocytes.

Drug Metab Dispos 2013 Oct 9;41(10):1763-8. Epub 2013 Aug 9.

Department of Medicine, Division of Clinical Pharmacology (A.R., S.P., Z.D., D.A.F., T.C.S.), and Department of Medical and Molecular Genetics (A.R., Y.L., H.L., C.G., L.L.), Indiana University School of Medicine, Indianapolis, Indiana; and Division of Clinical Pharmacology and Innovative Therapeutics, the Children's Mercy Hospital and Clinics, Kansas City, Missouri (A.G.).

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http://dx.doi.org/10.1124/dmd.113.052886DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3781376PMC
October 2013

Complexities of CYP2D6 gene analysis and interpretation.

Authors:
Andrea Gaedigk

Int Rev Psychiatry 2013 Oct;25(5):534-53

Children's Mercy Hospital and Clinics, Division of Clinical Pharmacology and Innovative Therapeutics , Kansas City, Missouri , USA.

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http://dx.doi.org/10.3109/09540261.2013.825581DOI Listing
October 2013

High-resolution melt analysis to detect sequence variations in highly homologous gene regions: application to CYP2B6.

Pharmacogenomics 2013 Jun;14(8):913-22

Division of Clinical Pharmacology & Therapeutic Innovation, The Children's Mercy Hospital & Clinics, 2401 Gillham Road, Kansas City, MO 64108, USA.

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http://dx.doi.org/10.2217/pgs.13.66DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3866959PMC
June 2013

Characterization of the CYP2D6 gene locus and metabolic activity in Indo- and Afro-Trinidadians: discovery of novel allelic variants.

Pharmacogenomics 2013 Feb;14(3):261-76

Pharmacology Unit, Department of Paraclinical Sciences, Faculty of Medical Sciences, The University of The West Indies, St Augustine, Trinidad & Tobago.

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http://dx.doi.org/10.2217/pgs.12.207DOI Listing
February 2013

The neuroprotective enzyme CYP2D6 increases in the brain with age and is lower in Parkinson's disease patients.

Neurobiol Aging 2012 Sep 29;33(9):2160-71. Epub 2011 Sep 29.

Centre for Addiction and Mental Health (CAMH) and Departments of Psychiatry, Pharmacology, and Toxicology, University of Toronto, Ontario, Canada.

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http://dx.doi.org/10.1016/j.neurobiolaging.2011.08.014DOI Listing
September 2012

Defining risk factors for red man syndrome in children and adults.

Pediatr Infect Dis J 2012 May;31(5):464-8

Department of Pediatrics, Medical Research, Children's Mercy Hospitals and Clinics and the University of Missouri-Kansas City, Kansas City, MO 64108, USA.

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http://dx.doi.org/10.1097/INF.0b013e31824e10d7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3333837PMC
May 2012

In silico and in vitro identification of microRNAs that regulate hepatic nuclear factor 4α expression.

Drug Metab Dispos 2012 Apr 9;40(4):726-33. Epub 2012 Jan 9.

Department of Medicine, Division of Clinical Pharmacology, Indiana University School of Medicine, Indianapolis, Indiana, USA.

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http://dmd.aspetjournals.org/cgi/doi/10.1124/dmd.111.040329
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http://dx.doi.org/10.1124/dmd.111.040329DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3310421PMC
April 2012

CYP2D6, SULT1A1 and UGT2B17 copy number variation: quantitative detection by multiplex PCR.

Pharmacogenomics 2012 Jan 23;13(1):91-111. Epub 2011 Nov 23.

Division of Pediatric Pharmacology & Medical Toxicology, The Children's Mercy Hospital & Clinics, 2401 Gillham Rd, Kansas City, MO 64108, USA.

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http://dx.doi.org/10.2217/pgs.11.135DOI Listing
January 2012

Identification of Novel CYP2D7-2D6 Hybrids: Non-Functional and Functional Variants.

Front Pharmacol 2010 4;1:121. Epub 2010 Oct 4.

Division of Developmental Pharmacology and Experimental Therapeutics, The Children's Mercy Hospital and Clinics Kansas City, MO, USA.

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http://journal.frontiersin.org/article/10.3389/fphar.2010.00
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http://dx.doi.org/10.3389/fphar.2010.00121DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3153001PMC
November 2011

Detection and characterization of the CYP2D6*9x2 gene duplication in two Spanish populations: resolution of AmpliChip CYP450 test no-calls.

Pharmacogenomics 2011 Nov;12(11):1617-22

Laboratori de Referencia de Catalunya, El Prat de Llobregat, Barcelona, Spain.

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http://dx.doi.org/10.2217/pgs.11.107DOI Listing
November 2011

Genetic transmission of cytochrome P450 2D6 (CYP2D6) ultrarapid metabolism: implications for breastfeeding women taking codeine.

Curr Drug Saf 2011 Feb;6(1):36-9

Division of Clinical Pharmacology and Toxicology, and the Motherisk Program, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, Canada.

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http://dx.doi.org/10.2174/157488611794479991DOI Listing
February 2011

Discovery of the nonfunctional CYP2D6 31 allele in Spanish, Puerto Rican, and US Hispanic populations.

Eur J Clin Pharmacol 2010 Sep 16;66(9):859-64. Epub 2010 May 16.

Division of Developmental Pharmacology & Experimental Therapeutics, Children's Mercy Hospital and Clinics, 2401 Gillham Road, Kansas City, MO 64108, USA.

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http://dx.doi.org/10.1007/s00228-010-0831-4DOI Listing
September 2010

Genetic variants of the drug-metabolizing enzyme CYP2D6 in Puerto Rican psychiatry patients: a preliminary report and potential implications for breast cancer patients.

P R Health Sci J 2010 Sep;29(3):299-304

Department of Psychiatry, University of Puerto Rico School of Medicine, San Juan, Puerto Rico 00936.

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September 2010

Impact of the CYP2C19*17 allele on the pharmacokinetics of omeprazole and pantoprazole in children: evidence for a differential effect.

Drug Metab Dispos 2010 Jun 11;38(6):894-7. Epub 2010 Mar 11.

Director, Pharmacogenetics Core Laboratory, Division of Clinical Pharmacology and Medical Toxicology, Children's Mercy Hospitals and Clinics, 2401 Gillham Road, Kansas City, MO 64108, USA.

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http://dx.doi.org/10.1124/dmd.109.030601DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2879959PMC
June 2010

Variability in drug metabolizing enzyme activity in HIV-infected patients.

Eur J Clin Pharmacol 2010 May 19;66(5):475-85. Epub 2010 Jan 19.

School of Pharmacy, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

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http://dx.doi.org/10.1007/s00228-009-0777-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2855129PMC
May 2010

UGT2B17 and SULT1A1 gene copy number variation (CNV) detection by LabChip microfluidic technology.

Clin Chem Lab Med 2010 May;48(5):627-33

Section of Developmental Pharmacology and Experimental Therapeutics, The Children's Mercy Hospital and Clinics, Kansas City, MO 64108 , USA.

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http://dx.doi.org/10.1515/CCLM.2010.128DOI Listing
May 2010

CYP2D7-2D6 hybrid tandems: identification of novel CYP2D6 duplication arrangements and implications for phenotype prediction.

Pharmacogenomics 2010 Jan;11(1):43-53

Section of Developmental Pharmacology & Experimental Therapeutics, The Children's Mercy Hospital and Clinics, 2401 Gillham Road, Kansas City, MO 62108, USA.

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https://www.futuremedicine.com/doi/10.2217/pgs.09.133
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http://dx.doi.org/10.2217/pgs.09.133DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6556886PMC
January 2010

Identification of a novel non-functional CYP2D6 allele, CYP2D6*69, in a Caucasian poor metabolizer individual.

Eur J Clin Pharmacol 2009 Jan 17;65(1):97-100. Epub 2008 Sep 17.

Section of Developmental Pharmacology and Experimental Therapeutics, Children's Mercy Hospital & Clinics, 2401 Gillham Road, Kansas City, MO 64108, USA.

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http://dx.doi.org/10.1007/s00228-008-0559-6DOI Listing
January 2009

Single-dose pharmacokinetics of oral and intravenous pantoprazole in children and adolescents.

J Clin Pharmacol 2008 Nov 29;48(11):1356-65. Epub 2008 Jul 29.

Division of Pediatric Pharmacology and Medical Toxicology, The Children's Mercy Hospitals and Clinics, 2401 Gillham Road, Kansas City, MO 64108, USA.

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http://dx.doi.org/10.1177/0091270008321811DOI Listing
November 2008

Evaluation of a [13C]-dextromethorphan breath test to assess CYP2D6 phenotype.

J Clin Pharmacol 2008 Sep;48(9):1041-51

Section of Developmental Pharmacology and Experimental Therapeutics, Department of Pediatrics, Children's Mercy Hospitals and Clinics, 2401 Gillham Road, Kansas City, MO 64108, USA.

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http://dx.doi.org/10.1177/0091270008319709DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4791047PMC
September 2008

Six-month, prospective, longitudinal, open-label caffeine and dextromethorphan phenotyping study in children with growth hormone deficiency receiving recombinant human growth hormone replacement.

Clin Ther 2008 Sep;30(9):1687-99

Kosair Charities Pediatric Clinical Research Unit, Department of Pediatrics, School of Medicine, University of Louisville, Louisville, Kentucky 40202, USA.

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http://dx.doi.org/10.1016/j.clinthera.2008.09.012DOI Listing
September 2008

The CYP2D6 gene locus in South African Coloureds: unique allele distributions, novel alleles and gene arrangements.

Eur J Clin Pharmacol 2008 May 17;64(5):465-75. Epub 2008 Jan 17.

Section of Developmental Pharmacology and Experimental Therapeutics, Children's Mercy Hospital & Clinics, 2401 Gillham Road, Kansas City, MO 64108, USA.

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http://dx.doi.org/10.1007/s00228-007-0445-7DOI Listing
May 2008

Interindividual variability in acetaminophen sulfation by human fetal liver: implications for pharmacogenetic investigations of drug-induced birth defects.

Birth Defects Res A Clin Mol Teratol 2008 Mar;82(3):155-65

Division of Clinical Pharmacology, Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA.

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http://dx.doi.org/10.1002/bdra.20535DOI Listing
March 2008

Multilocus genotyping identifies infections by multiple strains of Trichophyton tonsurans.

J Clin Microbiol 2007 Jun 18;45(6):1949-53. Epub 2007 Apr 18.

Division of Pediatric Clinical Pharmacology and Medical Toxicology, The Children's Mercy Hospitals and Clinics, Kansas City, MO 64108, USA.

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http://dx.doi.org/10.1128/JCM.02610-06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1933046PMC
June 2007

Tracking Trichophyton tonsurans through a large urban child care center: defining infection prevalence and transmission patterns by molecular strain typing.

Pediatrics 2006 Dec;118(6):2365-73

Department of Pediatric Clinical Pharmacology, Children's Mercy Hospitals and Clinics, 2401 Gillham Rd, Suite 0411, Kansas City, MO 64108, USA.

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http://dx.doi.org/10.1542/peds.2006-2065DOI Listing
December 2006

Variability of CYP2J2 expression in human fetal tissues.

J Pharmacol Exp Ther 2006 Nov 25;319(2):523-32. Epub 2006 Jul 25.

Children's Mercy Hospital, Division of Clinical Pharmacology, 2401 Gillham Rd., Kansas City, MO 64108, USA.

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http://dx.doi.org/10.1124/jpet.106.109215DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1876721PMC
November 2006

Pharmacogenetics of morphine poisoning in a breastfed neonate of a codeine-prescribed mother.

Lancet 2006 Aug;368(9536):704

Motherisk Program, Hospital for Sick Children, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada.

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http://dx.doi.org/10.1016/S0140-6736(06)69255-6DOI Listing
August 2006

Effects of fluvastatin and cigarette smoking on CYP2C9 activity measured using the probe S-warfarin.

Eur J Clin Pharmacol 2006 Jun 27;62(6):431-6. Epub 2006 Apr 27.

Clinical Pharmacology Research Center, Bassett Healthcare, One Atwell Road, Cooperstown, NY 13326-1394, USA.

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http://dx.doi.org/10.1007/s00228-006-0124-0DOI Listing
June 2006