Publications by authors named "Andrea E Prota"

50Publications

Structural Basis of Noscapine Activation for Tubulin Binding.

J Med Chem 2020 Aug 29;63(15):8495-8501. Epub 2020 Jul 29.

Centro de Investigaciones Biológicas Margarita Salas-CSIC, Ramiro de Maeztu, 9, C.P. 28040 Madrid, Spain.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acs.jmedchem.0c00855DOI Listing
August 2020

Pharmaceutical-Grade Rigosertib Is a Microtubule-Destabilizing Agent.

Mol Cell 2020 07;79(1):191-198.e3

Department of Cellular & Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA; Howard Hughes Medical Institute, University of California, San Francisco, San Francisco, CA 94158, USA; Center for RNA Systems Biology, University of California, San Francisco, San Francisco, CA 94158, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.molcel.2020.06.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7332992PMC
July 2020

Structural Refinement of the Tubulin Ligand (+)-Discodermolide to Attenuate Chemotherapy-Mediated Senescence.

Mol Pharmacol 2020 08 26;98(2):156-167. Epub 2020 Jun 26.

Department of Chemistry, Monell Chemical Senses Center and Laboratory for Research on the Structure of Matter, University of Pennsylvania, Philadelphia, Pennsylvania (B.G., N.Z., A.B.S.); Departments of Molecular Pharmacology (A.R.-G., S.B.H., H.M.M.), Epidemiology (K.Y.), and Medicine (H.M.M.), Albert Einstein College of Medicine, Bronx, New York; Laboratory of Biomolecular Research, Division of Biology and Chemistry, Paul Scherrer Institut, Villigen, Switzerland (A.E.P., T.M., M.O.S.); and University of Basel, Biozentrum, Basel, Switzerland (M.O.S.)

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1124/mol.119.117457DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7362599PMC
August 2020

Crystal Structure of a Heterotetrameric Katanin p60:p80 Complex.

Structure 2019 09 25;27(9):1375-1383.e3. Epub 2019 Jul 25.

Laboratory of Biomolecular Research, Division of Biology and Chemistry, Paul Scherrer Institut, 5232 Villigen PSI, Switzerland. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.str.2019.07.002DOI Listing
September 2019

VISAGE Reveals a Targetable Mitotic Spindle Vulnerability in Cancer Cells.

Cell Syst 2019 07 10;9(1):74-92.e8. Epub 2019 Jul 10.

Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Center for Precision Cancer Medicine, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Electronic address:

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S24054712193019
Publisher Site
http://dx.doi.org/10.1016/j.cels.2019.05.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6688637PMC
July 2019

Alternative folding to a monomer or homopolymer is a common feature of the type 1 pilus subunit FimA from enteroinvasive bacteria.

J Biol Chem 2019 07 24;294(27):10553-10563. Epub 2019 May 24.

From the Institute of Molecular Biology and Biophysics, ETH Zurich, Otto-Stern-Weg 5, CH-8093 Zurich and

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.RA119.008610DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6615685PMC
July 2019

Conformational Properties of the Chemotherapeutic Drug Analogue Epothilone A: How to Model a Flexible Protein Ligand Using Scarcely Available Experimental Data.

J Chem Inf Model 2019 05 25;59(5):2218-2230. Epub 2019 Mar 25.

Laboratory of Biomolecular Research, Division of Biology and Chemistry , Paul Scherrer Institut , CH-5232 Villigen , Switzerland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acs.jcim.9b00171DOI Listing
May 2019

Structure-activity relationships, biological evaluation and structural studies of novel pyrrolonaphthoxazepines as antitumor agents.

Eur J Med Chem 2019 Jan 3;162:290-320. Epub 2018 Nov 3.

European Research Centre for Drug Discovery and Development (NatSynDrugs), University of Siena, Department of Biotechnology, Chemistry and Pharmacy, DoE Department of Excellence 2018-2022, via Aldo Moro 2, I-53100, Siena, Italy; Istituto Toscano Tumori, University of Siena, via Aldo Moro 2, I-53100, Siena, Italy; Department of Pharmacy, University of Napoli Federico II, DoE Department of Excellence 2018-2022, Via D. Montesano 49, 80131, Napoli, Italy.

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S02235234183095
Publisher Site
http://dx.doi.org/10.1016/j.ejmech.2018.11.004DOI Listing
January 2019

Microtubule-Targeting Agents: Strategies To Hijack the Cytoskeleton.

Trends Cell Biol 2018 10 2;28(10):776-792. Epub 2018 Jun 2.

Laboratory of Biomolecular Research, Division of Biology and Chemistry, Paul Scherrer Institut, 5232 Villigen, Switzerland. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.tcb.2018.05.001DOI Listing
October 2018

A fluorescence anisotropy assay to discover and characterize ligands targeting the maytansine site of tubulin.

Nat Commun 2018 05 29;9(1):2106. Epub 2018 May 29.

Laboratory of Biomolecular Research, Division of Biology and Chemistry, Paul Scherrer Institut, Villigen PSI, 5232, Switzerland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41467-018-04535-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5974090PMC
May 2018

Structural Basis of Formation of the Microtubule Minus-End-Regulating CAMSAP-Katanin Complex.

Structure 2018 03 26;26(3):375-382.e4. Epub 2018 Jan 26.

Cell Biology, Department of Biology, Faculty of Science, Utrecht University, Padualaan 8, 3584 Utrecht, the Netherlands. Electronic address:

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S09692126173044
Publisher Site
http://dx.doi.org/10.1016/j.str.2017.12.017DOI Listing
March 2018

Quinazolinone-Based Anticancer Agents: Synthesis, Antiproliferative SAR, Antitubulin Activity, and Tubulin Co-crystal Structure.

J Med Chem 2018 02 8;61(3):1031-1044. Epub 2018 Jan 8.

Medicinal Chemistry & Drug Discovery, Department of Pharmacology, University of Oxford , Mansfield Road, Oxford OX1 3QT, U.K.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acs.jmedchem.7b01474DOI Listing
February 2018

Structural basis of katanin p60:p80 complex formation.

Sci Rep 2017 11 2;7(1):14893. Epub 2017 Nov 2.

Laboratory of Biomolecular Research, Division of Biology and Chemistry, Paul Scherrer Institut, CH-5232, Villigen PSI, Switzerland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41598-017-14194-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5668312PMC
November 2017

Combined CRISPRi/a-Based Chemical Genetic Screens Reveal that Rigosertib Is a Microtubule-Destabilizing Agent.

Mol Cell 2017 Oct;68(1):210-223.e6

Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA; Howard Hughes Medical Institute, University of California, San Francisco, San Francisco, CA 94158, USA; Center for RNA Systems Biology, University of California, San Francisco, San Francisco, CA 94158, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.molcel.2017.09.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5640507PMC
October 2017

Short Linear Sequence Motif LxxPTPh Targets Diverse Proteins to Growing Microtubule Ends.

Structure 2017 06 25;25(6):924-932.e4. Epub 2017 May 25.

Laboratory of Biomolecular Research, Division of Biology and Chemistry, Paul Scherrer Institut, 5232 Villigen PSI, Switzerland. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.str.2017.04.010DOI Listing
June 2017

Structural Basis of Microtubule Stabilization by Discodermolide.

Chembiochem 2017 05 27;18(10):905-909. Epub 2017 Mar 27.

Laboratory of Biomolecular Research, Department of Biology and Chemistry, Paul Scherrer Institut, OFLC/111, 5232, Villigen PSI, Switzerland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/cbic.201600696DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5559732PMC
May 2017

Structural Basis of Microtubule Destabilization by Potent Auristatin Anti-Mitotics.

PLoS One 2016 12;11(8):e0160890. Epub 2016 Aug 12.

Department of Biology and Chemistry, Laboratory of Biomolecular Research, Paul Scherrer Institut, Villigen PSI, Switzerland.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0160890PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4982639PMC
August 2017

Pironetin Binds Covalently to αCys316 and Perturbs a Major Loop and Helix of α-Tubulin to Inhibit Microtubule Formation.

J Mol Biol 2016 07 6;428(15):2981-8. Epub 2016 Jul 6.

Laboratory of Biomolecular Research, Department of Biology and Chemistry, Paul Scherrer Institut, 5232 Villigen, Switzerland. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jmb.2016.06.023DOI Listing
July 2016

Termination of Protofilament Elongation by Eribulin Induces Lattice Defects that Promote Microtubule Catastrophes.

Curr Biol 2016 07 16;26(13):1713-1721. Epub 2016 Jun 16.

Laboratory of Biomolecular Research, Department of Biology and Chemistry, Paul Scherrer Institut, 5232 Villigen, Switzerland. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cub.2016.04.053DOI Listing
July 2016

A new tubulin-binding site and pharmacophore for microtubule-destabilizing anticancer drugs.

Proc Natl Acad Sci U S A 2014 Sep 11;111(38):13817-21. Epub 2014 Aug 11.

Department of Biology and Chemistry, Laboratory of Biomolecular Research, Paul Scherrer Institut, 5232 Villigen PSI, Switzerland;

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.1408124111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4183314PMC
September 2014

The novel microtubule-destabilizing drug BAL27862 binds to the colchicine site of tubulin with distinct effects on microtubule organization.

J Mol Biol 2014 Apr 11;426(8):1848-60. Epub 2014 Feb 11.

Laboratory of Biomolecular Research, Department of Biology and Chemistry Paul Scherrer Institut, 5232 Villigen, Switzerland. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jmb.2014.02.005DOI Listing
April 2014

Structural basis of microtubule stabilization by laulimalide and peloruside A.

Angew Chem Int Ed Engl 2014 Feb 27;53(6):1621-5. Epub 2014 Jan 27.

Department of Biology and Chemistry, Laboratory of Biomolecular Research, Paul Scherrer Institut, 5232 Villigen PSI (Switzerland).

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/anie.201307749DOI Listing
February 2014

Structural and mechanistic insights into VEGF receptor 3 ligand binding and activation.

Proc Natl Acad Sci U S A 2013 Aug 22;110(32):12960-5. Epub 2013 Jul 22.

Translational Cancer Biology Program, Institute for Molecular Medicine Finland and Helsinki University Central Hospital, Biomedicum Helsinki, University of Helsinki, 00014 Helsinki, Finland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.1301415110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3740881PMC
August 2013

Structural basis for universal corrinoid recognition by the cobalamin transport protein haptocorrin.

J Biol Chem 2013 Aug 11;288(35):25466-76. Epub 2013 Jul 11.

Center for Radiopharmaceutical Sciences, Paul Scherrer Institut, CH-5232 Villigen PSI, Zürich, Switzerland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M113.483271DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3757208PMC
August 2013

Molecular mechanism of action of microtubule-stabilizing anticancer agents.

Science 2013 Feb 3;339(6119):587-90. Epub 2013 Jan 3.

Biomolecular Research, Paul Scherrer Institut, Villigen PSI, Switzerland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1126/science.1230582DOI Listing
February 2013

Structural determinants of growth factor binding and specificity by VEGF receptor 2.

Proc Natl Acad Sci U S A 2010 Feb;107(6):2425-30

Molecular Cancer Biology Program, Biomedicum Helsinki, Department of Pathology, Haartman Institute and Helsinki University Central Hospital, PO Box 63, University of Helsinki, Haartmaninkatu 8, FI-00014 Helsinki, Finland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.0914318107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2823880PMC
February 2010

Structure-function analysis of VEGF receptor activation and the role of coreceptors in angiogenic signaling.

Biochim Biophys Acta 2010 Mar 15;1804(3):567-80. Epub 2009 Sep 15.

Paul Scherrer Institut, Biomolecular Research, 5232 Villigen PSI, Switzerland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbapap.2009.09.002DOI Listing
March 2010

Mutational studies of Pa-AGOG DNA glycosylase from the hyperthermophilic crenarchaeon Pyrobaculum aerophilum.

DNA Repair (Amst) 2009 Jul 1;8(7):857-64. Epub 2009 May 1.

Biomolecular Research, Paul Scherrer Institut, CH-5232 Villigen, Switzerland.

View Article

Download full-text PDF

Source
http://linkinghub.elsevier.com/retrieve/pii/S156878640900093
Publisher Site
http://dx.doi.org/10.1016/j.dnarep.2009.03.009DOI Listing
July 2009

Orf virus VEGF-E NZ2 promotes paracellular NRP-1/VEGFR-2 coreceptor assembly via the peptide RPPR.

FASEB J 2008 Aug 8;22(8):3078-86. Epub 2008 May 8.

Paul Scherrer Institut, Laboratory of Biomolecular Research, Molecular Cell Biology, 5232 Villigen-PSI Switzerland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1096/fj.08-107219DOI Listing
August 2008

Structure determination of VEGF-E by sulfur SAD.

Acta Crystallogr D Biol Crystallogr 2006 Nov 18;62(Pt 11):1430-4. Epub 2006 Oct 18.

Swiss Light Source, Paul Scherrer Institut, Villigen-PSI, Switzerland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1107/S0907444906036742DOI Listing
November 2006

Crystal structure of human junctional adhesion molecule 1: implications for reovirus binding.

Proc Natl Acad Sci U S A 2003 Apr 15;100(9):5366-71. Epub 2003 Apr 15.

Laboratory of Developmental Immunology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.0937718100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC404559PMC
April 2003

The crystal structure of human CD21: Implications for Epstein-Barr virus and C3d binding.

Proc Natl Acad Sci U S A 2002 Aug 16;99(16):10641-6. Epub 2002 Jul 16.

Harvard Medical School, Division of Experimental Medicine and Infectious Diseases, Beth Israel Deaconess Medical Center, Harvard Institutes of Medicine, 4 Blackfan Circle, Boston, MA 02115, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.162360499DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC124999PMC
August 2002