Publications by authors named "Andrea Armirotti"

100Publications

Volumetric Absorptive Microsampling of Blood for Untargeted Lipidomics.

Molecules 2021 Jan 7;26(2). Epub 2021 Jan 7.

Analytical Chemistry Lab, Fondazione Istituto Italiano di Tecnologia, Via Morego 30, 16163 Genova, Italy.

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January 2021

Isobaric Labeling Proteomics Allows a High-Throughput Investigation of Protein Corona Orientation.

Anal Chem 2020 Dec 7. Epub 2020 Dec 7.

Analytical Chemistry Lab, Istituto Italiano di Tecnologia, Via Morego 30, 16163 Genova, Italy.

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December 2020

Proteomics and Metabolomics for Cystic Fibrosis Research.

Int J Mol Sci 2020 Jul 30;21(15). Epub 2020 Jul 30.

D3PharmaChemistry, Istituto Italiano di Tecnologia, Via Morego 30, 16163 Genova, Italy.

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July 2020

Whole blood and oral fluid microsampling for the monitoring of patients under treatment with antidepressant drugs.

J Pharm Biomed Anal 2020 Sep 23;188:113384. Epub 2020 May 23.

Research Group of Pharmaco-Toxicological Analysis (PTA Lab), Department of Pharmacy and Biotechnology (FaBiT), Alma Mater Studiorum - University of Bologna, Via Belmeloro 6, 40126, Bologna, Italy.

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September 2020

LC-MS/MS analysis of twelve neurotransmitters and amino acids in mouse cerebrospinal fluid.

J Neurosci Methods 2020 07 16;341:108760. Epub 2020 May 16.

Graphene Labs, Fondazione Istituto Italiano di Tecnologia, Genova, Italy; Analytical Chemistry and In-vivo Pharmacology Facility, Fondazione Istituto Italiano di Tecnologia, via Morego 30, 16163 Genova, Italy. Electronic address:

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July 2020

Deletion of astrocytic BMAL1 results in metabolic imbalance and shorter lifespan in mice.

Glia 2020 06 13;68(6):1131-1147. Epub 2019 Dec 13.

Neurobiology of miRNA lab, Fondazione Istituto Italiano di Tecnologia, Genoa, Italy.

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June 2020

Deoxysphingolipids as candidate biomarkers for a novel mutation associated with HSAN-I.

Neurol Genet 2019 Dec 8;5(6):e365. Epub 2019 Oct 8.

Department of Neuroscience (F.B., F.T., M.F., T.C., G.M.F.), Biomedicine and Movement Sciences, University of Verona; Department of Neurosciences (F.B., F.T., M.F., T.C., G.M.F.), AOUI Verona; Analytical Chemistry Lab (A.A.), Fondazione Istituto Italiano di Tecnologia; and Department of Neurosciences (L.N.), Rehabilitation, Ophthalmology, Genetics and Maternal-Infantile Sciences, University of Genoa & IRCCS Ospedale Policlinico San Martino, Genova, Italy.

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December 2019

Traveling Wave Ion Mobility-Mass Spectrometry to Enhance the Detection of Low Abundance Features in Untargeted Lipidomics.

Methods Mol Biol 2020 ;2084:103-117

Analytical Chemistry and In-Vivo Pharmacology, Fondazione Istituto Italiano di Tecnologia, Genoa, Italy.

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December 2020

Comparative Proteomic Analysis of Proteins Involved in Bioenergetics Pathways Associated with Human Sperm Motility.

Int J Mol Sci 2019 Jun 19;20(12). Epub 2019 Jun 19.

Dipartimento di Scienze e Tecnologie Biologiche ed Ambientali, Università del Salento, Via Provinciale Lecce-Monteroni, I-73100 Lecce, Italy.

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June 2019

Diurnal Profiles of -Acylethanolamines in Goldfish Brain and Gastrointestinal Tract: Possible Role of Feeding.

Front Neurosci 2019 7;13:450. Epub 2019 May 7.

Departamento de Genética, Fisiología y Microbiología, Unidad Docente de Fisiología Animal, Facultad de Biología, Universidad Complutense de Madrid, Madrid, Spain.

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May 2019

MiR-135a-5p Is Critical for Exercise-Induced Adult Neurogenesis.

Stem Cell Reports 2019 06 23;12(6):1298-1312. Epub 2019 May 23.

Neurobiology of miRNA, Istituto Italiano di Tecnologia (IIT), Genoa, Italy. Electronic address:

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June 2019

An Increase in Membrane Cholesterol by Graphene Oxide Disrupts Calcium Homeostasis in Primary Astrocytes.

Small 2019 04 20;15(15):e1900147. Epub 2019 Mar 20.

Center for Synaptic Neuroscience and Technology and Graphene Labs, Istituto Italiano di Tecnologia, 16132, Genova, Italy.

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April 2019

Elevated plasma ceramide levels in post-menopausal women: a cross-sectional study.

Aging (Albany NY) 2019 01;11(1):73-88

Departments of Anatomy and Neurobiology, Biochemistry and Pharmacology, University of California Irvine, Irvine, CA 92697, USA.

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January 2019

A New Drug Delivery System Based on Tauroursodeoxycholic Acid and PEDOT.

Chemistry 2019 Feb 15;25(9):2322-2329. Epub 2019 Jan 15.

Center for Translational Neurophysiology of Speech and Communication, Istituto Italiano di Tecnologia, 44121, Ferrara, Italy.

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February 2019

SWATH label-free proteomics for cystic fibrosis research.

J Cyst Fibros 2019 07 19;18(4):501-506. Epub 2018 Oct 19.

Analytical Chemistry Lab, Fondazione Istituto Italiano di Tecnologia, Via Morego 30, 16163 Genova, Italy. Electronic address:

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July 2019

A Swath Label-Free Proteomics insight into the Faah Mouse Liver.

Sci Rep 2018 08 14;8(1):12142. Epub 2018 Aug 14.

Analytical Chemistry and In-vivo Facility, Fondazione Istituto Italiano di Tecnologia, via Morego 30, 16163, Genova, Italy.

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August 2018

A new SWATH ion library for mouse adult hippocampal neural stem cells.

Data Brief 2018 Jun 27;18:1-8. Epub 2018 Feb 27.

D3 PharmaChemistry, Fondazione Istituto Italiano di Tecnologia, Via Morego 30, 16163 Genova, Italy.

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June 2018

Biochemically Controlled Release of Dexamethasone Covalently Bound to PEDOT.

Chemistry 2018 Jul 25;24(41):10300-10305. Epub 2018 Jun 25.

Center for Translational Neurophysiology of Speech and Communication, Istituto Italiano di Tecnologia, 44121, Ferrara, Italy.

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July 2018

Author Correction: Patch clamp-assisted single neuron lipidomics.

Sci Rep 2018 Apr 25;8(1):6772. Epub 2018 Apr 25.

Department of Anatomy and Neurobiology, University of California, Irvine, Irvine, CA, 92697, USA.

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April 2018

Brain-wide Mapping of Endogenous Serotonergic Transmission via Chemogenetic fMRI.

Cell Rep 2017 Oct;21(4):910-918

Functional Neuroimaging Laboratory, Center for Neuroscience and Cognitive Systems, Istituto Italiano di Tecnologia, 38068 Rovereto, Italy; Biology Department, University of Pisa, 56127 Pisa, Italy.

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October 2017

The N-Acylethanolamine Acid Amidase Inhibitor ARN077 Suppresses Inflammation and Pruritus in a Mouse Model of Allergic Dermatitis.

J Invest Dermatol 2018 03 18;138(3):562-569. Epub 2017 Oct 18.

Departments of Anatomy and Neurobiology, Pharmacology, and Biological Chemistry, University of California, Irvine, California, USA. Electronic address:

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March 2018

Sphingomyelin as a myelin biomarker in CSF of acquired demyelinating neuropathies.

Sci Rep 2017 08 10;7(1):7831. Epub 2017 Aug 10.

Department of Neurosciences, Rehabilitation Ophthalmology, Genetics and Maternal-Infantile Sciences (DINOGMI) and CEBR, University of Genoa, Genoa, Italy.

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August 2017

Patch clamp-assisted single neuron lipidomics.

Sci Rep 2017 07 13;7(1):5318. Epub 2017 Jul 13.

Department of Anatomy and Neurobiology, University of California, Irvine, Irvine, CA, 92697, USA.

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July 2017

Synergic Functions of miRNAs Determine Neuronal Fate of Adult Neural Stem Cells.

Stem Cell Reports 2017 04 16;8(4):1046-1061. Epub 2017 Mar 16.

Neurobiology of miRNA Lab, Neuroscience and Brain Technologies Department, Istituto Italiano di Tecnologia, Via Morego 30, 16163 Genoa, Italy. Electronic address:

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April 2017

Astrocyte deletion of Bmal1 alters daily locomotor activity and cognitive functions via GABA signalling.

Nat Commun 2017 02 10;8:14336. Epub 2017 Feb 10.

Neurobiology of miRNA Lab, Neuroscience and Brain Technologies Department, Fondazione Istituto Italiano di Tecnologia, Via Morego 30, 16163 Genoa, Italy.

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February 2017

Lid domain plasticity and lipid flexibility modulate enzyme specificity in human monoacylglycerol lipase.

Biochim Biophys Acta Mol Cell Biol Lipids 2017 May 12;1862(5):441-451. Epub 2017 Jan 12.

Laboratory of Molecular Modeling and Drug Discovery, Istituto Italiano di Tecnologia, Via Morego 30, 16163 Genova, Italy; IAS-5/INM-9 Computational Biomedicine Forschungszentrum Jülich, Wilhelm-Johnen-Straße, 52428 Jülich, Germany. Electronic address:

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May 2017

Endogenous N-acyl taurines regulate skin wound healing.

Proc Natl Acad Sci U S A 2016 07 13;113(30):E4397-406. Epub 2016 Jul 13.

Drug Discovery and Development, Istituto Italiano di Tecnologia, 16163 Genoa, Italy; Department of Anatomy and Neurobiology, University of California, Irvine, CA 92697; Department of Pharmacology, University of California, Irvine, CA 92697; Department of Biological Chemistry, University of California, Irvine, CA 92697

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July 2016

Ion mobility mass spectrometry enhances low-abundance species detection in untargeted lipidomics.

Metabolomics 2016;12:50. Epub 2016 Feb 8.

Department of Drug Discovery and Development, Istituto Italiano di Tecnologia, via Morego 30, 16163 Genoa, Italy.

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February 2016

Potent multitarget FAAH-COX inhibitors: Design and structure-activity relationship studies.

Eur J Med Chem 2016 Feb 23;109:216-37. Epub 2015 Dec 23.

Drug Discovery and Development, Fondazione Istituto Italiano di Tecnologia, Via Morego 30, 16163 Genova, Italy. Electronic address:

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February 2016

Keys to Lipid Selection in Fatty Acid Amide Hydrolase Catalysis: Structural Flexibility, Gating Residues and Multiple Binding Pockets.

PLoS Comput Biol 2015 Jun 25;11(6):e1004231. Epub 2015 Jun 25.

Laboratory of Molecular Modeling and Drug Discovery, Istituto Italiano di Tecnologia, Genova, Italy.

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June 2015

Activity-Based Probe for N-Acylethanolamine Acid Amidase.

ACS Chem Biol 2015 Sep 23;10(9):2057-2064. Epub 2015 Jun 23.

Drug Discovery and Development, Istituto Italiano di Tecnologia, Via Morego 30, I-16163 Genova, Italy.

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September 2015

Peroxide-Dependent MGL Sulfenylation Regulates 2-AG-Mediated Endocannabinoid Signaling in Brain Neurons.

Chem Biol 2015 May;22(5):619-28

Department of Pharmacology, University of California, Irvine, Irvine, CA 92697, USA; Department of Anatomy and Neurobiology, University of California, 3101 Gillespie NRF, Irvine, CA 92697-1275, USA; Drug Discovery and Development, Istituto Italiano di Tecnologia, 16163 Genoa, Italy; Department of Biological Chemistry, University of California, Irvine, Irvine, CA 92697, USA. Electronic address:

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May 2015

Multitarget fatty acid amide hydrolase/cyclooxygenase blockade suppresses intestinal inflammation and protects against nonsteroidal anti-inflammatory drug-dependent gastrointestinal damage.

FASEB J 2015 Jun 10;29(6):2616-27. Epub 2015 Mar 10.

*Department of Drug Discovery and Development, Istituto Italiano di Tecnologia, Genoa, Italy; and Departments of Anatomy and Neurobiology and Pharmacology and Biological Chemistry, University of California-Irvine, Irvine, California, USA

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June 2015

Effects of Fatty Acid Amide Hydrolase (FAAH) Inhibitors in Non-Human Primate Models of Nicotine Reward and Relapse.

Neuropsychopharmacology 2015 Aug 10;40(9):2185-97. Epub 2015 Mar 10.

Preclinical Pharmacology Section, Behavioral Neuroscience Research Branch, Intramural Research Program, National Institute on Drug Abuse, NIH, DHHS, Baltimore, MD, USA.

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August 2015

Rapid evaluation of 25 key sphingolipids and phosphosphingolipids in human plasma by LC-MS/MS.

Anal Bioanal Chem 2015 Jul 8;407(17):5189-98. Epub 2015 Mar 8.

Department of Drug Discovery and Development, Istituto Italiano di Tecnologia, via Morego 30, 16163, Genoa, Italy.

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July 2015

Multitarget drug discovery for Alzheimer's disease: triazinones as BACE-1 and GSK-3β inhibitors.

Angew Chem Int Ed Engl 2015 Jan 11;54(5):1578-82. Epub 2014 Dec 11.

Istituto Italiano di Tecnologia, D3 via Morego 30, 16163 Genova (Italy); Department of Pharmacy and Biotechonology, University of Bologna via Belmeloro 6/Selmi 3, 40126 Bologna (Italy).

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January 2015

Structural determinants of peripheral O-arylcarbamate FAAH inhibitors render them dual substrates for Abcb1 and Abcg2 and restrict their access to the brain.

Pharmacol Res 2014 Sep 30;87:87-93. Epub 2014 Jun 30.

Department of Anatomy and Neurobiology, University of California, Irvine 92697-4621, USA; Drug Discovery and Development, Fondazione Istituto Italiano di Tecnologia, via Morego 30, I-16163 Genova, Italy. Electronic address:

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September 2014

Role of oleoylethanolamide as a feeding regulator in goldfish.

J Exp Biol 2014 Aug 22;217(Pt 15):2761-9. Epub 2014 May 22.

Departamento de Fisiología (Fisiología Animal II), Facultad de Biología, Universidad Complutense de Madrid, 28040 Madrid, Spain

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August 2014

3-Aminoazetidin-2-one derivatives as N-acylethanolamine acid amidase (NAAA) inhibitors suitable for systemic administration.

ChemMedChem 2014 Jul 14;9(7):1602-14. Epub 2014 May 14.

Drug Discovery and Development, Istituto Italiano di Tecnologia, Via Morego 30, 16163 Genova (Italy), Fax: (+39) 010-71781228.

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July 2014

Sample preparation and orthogonal chromatography for broad polarity range plasma metabolomics: application to human subjects with neurodegenerative dementia.

Anal Biochem 2014 Jun 4;455:48-54. Epub 2014 Apr 4.

Department of Drug Discovery and Development, Istituto Italiano di Tecnologia, Via Morego 30, 16163 Genova, Italy; Department of Anatomy and Neurobiology, University of California, Irvine, CA 92697, USA; Department of Pharmacology, University of California, Irvine, CA 92697, USA; Department of Biological Chemistry, University of California, Irvine, CA 92697, USA. Electronic address:

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June 2014

β-Lactones Inhibit N-acylethanolamine Acid Amidase by S-Acylation of the Catalytic N-Terminal Cysteine.

ACS Med Chem Lett 2012 May 6;3(5):422-6. Epub 2012 Apr 6.

Department of Drug Discovery and Development, Istituto Italiano di Tecnologia , via Morego, 30, 16163 Genova, Italy ; Departments of Pharmacology, University of California, Irvine , 360 MSRII, California 92697-4625, United States.

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May 2012

Achievements and perspectives of top-down proteomics.

Proteomics 2010 Oct;10(20):3566-76

Advanced Biotechnology Center, Largo Rosanna Benzi, Genova, Italy.

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October 2010

Top-down proteomics with a quadrupole time-of-flight mass spectrometer and collision-induced dissociation.

Rapid Commun Mass Spectrom 2009 Mar;23(5):661-6

Centro Biotecnologie Avanzate, Largo Rosanna Benzi 10, 16132 Genova, Italy.

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March 2009

Structural characterization of the As/Sb reductase LmACR2 from Leishmania major.

J Mol Biol 2009 Mar 29;386(5):1229-39. Epub 2008 Jul 29.

Department of Biochemistry and Molecular Biology, School of Medicine, Wayne State University, 540 East Canfield Avenue, Detroit, MI 48201, USA.

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March 2009

Taxanes from Shells and Leaves of Corylus avellana.

J Nat Prod 2008 Jan 29;71(1):58-60. Epub 2007 Dec 29.

Department of Translational Oncology, National Institute for Cancer Research, IST, Genova, Italy.

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January 2008

Electrospray ionization ion trap multiple-stage mass spectrometric fragmentation pathways of leucine and isoleucine: an ab initio computational study.

Rapid Commun Mass Spectrom 2007 ;21(19):3180-4

Department of Experimental Medicine and Center of Excellence for Biomedical Research, University of Genoa, Viale Benedetto XV, 7 Genova, Italy.

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November 2007

In vitro cell cultures obtained from different explants of Corylus avellana produce Taxol and taxanes.

BMC Biotechnol 2006 Dec 6;6:45. Epub 2006 Dec 6.

Laboratory of Plant and Pharmaceutical Biotechnology, Advanced Biotechnology Center (ABC), Largo R. Benzi, 10, 16132 Genova, Italy.

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December 2006

How to discriminate between leucine and isoleucine by low energy ESI-TRAP MSn.

J Am Soc Mass Spectrom 2007 Jan 28;18(1):57-63. Epub 2006 Sep 28.

Department of Experimental Medicine-Biochemistry Section and Center of Excellence for Biomedical Research (DIMES), University of Genoa, Genoa, Italy.

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January 2007

Matrix-assisted laser desorption/ionization mass spectrometry of taxanes.

Rapid Commun Mass Spectrom 2005 ;19(23):3531-8

Department of Experimental Medicine and Center of Excellence for Biomedical Research, University of Genoa, Viale Benedetto XV 7, 16132 Genova, Italy.

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January 2006