Publications by authors named "Andrea Alimonti"

63Publications

Senescence Reprogramming by TIMP1 Deficiency Promotes Prostate Cancer Metastasis.

Cancer Cell 2020 Oct 26. Epub 2020 Oct 26.

Institute of Oncology Research (IOR), Oncology Institute of Southern Switzerland (IOSI), Bellinzona 6500, Switzerland; Università della Svizzera Italiana, Lugano 6900, Switzerland; Department of Medicine, University of Padua, Padua 35128, Italy; Department of Health Sciences and Technology (D-HEST) ETH Zurich, Zurich 8093, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2020.10.012DOI Listing
October 2020

In and out from senescence.

Nat Cell Biol 2020 07;22(7):753-754

University of Padova, Department of Medicine & Veneto Institute of Molecular Medicine, Padova, Italy.

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http://dx.doi.org/10.1038/s41556-020-0540-xDOI Listing
July 2020

Prostate carcinogenesis: inflammatory storms.

Nat Rev Cancer 2020 08 16;20(8):455-469. Epub 2020 Jun 16.

Institute of Oncology Research, Bellinzona, Switzerland.

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http://dx.doi.org/10.1038/s41568-020-0267-9DOI Listing
August 2020

Re-education of Tumor-Associated Macrophages by CXCR2 Blockade Drives Senescence and Tumor Inhibition in Advanced Prostate Cancer.

Cell Rep 2019 08;28(8):2156-2168.e5

Institute of Oncology Research (IOR), 6500 Bellinzona, Switzerland; Faculty of Medicine, Università della Svizzera Italiana, 1011 Lugano, Switzerland; Department of Medicine, University of Padua, 35131 Padua, Italy; Medical Oncology, Oncology Institute of Southern Switzerland, 6500 Bellinzona, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2019.07.068DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6715643PMC
August 2019

Cellular Senescence: Aging, Cancer, and Injury.

Physiol Rev 2019 04;99(2):1047-1078

Institute of Oncology Research (IOR), Oncology Institute of Southern Switzerland , Bellinzona , Switzerland ; University of Groningen, European Research Institute for the Biology of Ageing, University Medical Center Groningen , Groningen , The Netherlands ; IOR, Oncology Institute of Southern Switzerland , Bellinzona , Switzerland ; Università della Svizzera Italiana, Faculty of Biomedical Sciences , Lugano , Italy ; Faculty of Biology and Medicine, University of Lausanne UNIL , Lausanne , Switzerland ; and Department of Medicine, Venetian Institute of Molecular Medicine, University of Padova , Padova , Italy.

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http://dx.doi.org/10.1152/physrev.00020.2018DOI Listing
April 2019

How phosphorylation influences E1 subunit pyruvate dehydrogenase: A computational study.

Sci Rep 2018 10 2;8(1):14683. Epub 2018 Oct 2.

Institute for Research in Biomedicine (IRB), Università della Svizzera Italiana (USI), Via Vincenzo Vela 6, CH-6500, Bellinzona, Switzerland.

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http://www.nature.com/articles/s41598-018-33048-z
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http://dx.doi.org/10.1038/s41598-018-33048-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6168537PMC
October 2018

Aging tumour cells to cure cancer: "pro-senescence" therapy for cancer.

Swiss Med Wkly 2017 17;147:w14367. Epub 2017 Jan 17.

Institute of Research in Oncology, Bellinzona, Switzerland.

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http://dx.doi.org/10.4414/smw.2017.14367DOI Listing
October 2017

Sjögren's syndrome patients with ectopic germinal centers present with a distinct salivary proteome.

Rheumatology (Oxford) 2016 Jun 26;55(6):1127-37. Epub 2016 Feb 26.

Broegelmann Research Laboratory, Department of Clinical Science, University of Bergen, Department of Rheumatology, Haukeland University Hospital.

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http://dx.doi.org/10.1093/rheumatology/kew013DOI Listing
June 2016

Non-Cell-Autonomous Regulation of Cellular Senescence in Cancer.

Trends Cell Biol 2016 Mar 9;26(3):215-226. Epub 2015 Nov 9.

Institute of Oncology Research (IOR), Oncology Institute of Southern Switzerland, Bellinzona 6500, Switzerland; Faculty of Biology and Medicine, University of Lausanne (UNIL), Lausanne 1011, Switzerland. Electronic address:

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http://www.cell.com/trends/cell-biology/pdf/S0962-8924(15)00
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http://dx.doi.org/10.1016/j.tcb.2015.10.005DOI Listing
March 2016

Tumor-infiltrating myeloid cells drive senescence evasion and chemoresistance in tumors.

Oncoimmunology 2015 Sep 3;4(9):e988473. Epub 2015 Jun 3.

Institute of Oncology Research (IOR); Oncology Institute of Southern Switzerland ; Bellinzona, Switzerland.

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http://dx.doi.org/10.4161/2162402X.2014.988473DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4570142PMC
September 2015

Molecular Pathways: Targeting Tumor-Infiltrating Myeloid-Derived Suppressor Cells for Cancer Therapy.

Clin Cancer Res 2015 Jul 12;21(14):3108-12. Epub 2015 May 12.

Institute of Oncology Research (IOR), Oncology Institute of Southern Switzerland, Bellinzona, Switzerland. Faculty of Biology and Medicine, University of Lausanne UNIL, Lausanne, Switzerland.

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http://dx.doi.org/10.1158/1078-0432.CCR-14-2261DOI Listing
July 2015

Enhancing chemotherapy efficacy by reprogramming the senescence-associated secretory phenotype of prostate tumors: A way to reactivate the antitumor immunity.

Oncoimmunology 2015 Mar 22;4(3):e994380. Epub 2015 Jan 22.

Institute of Oncology Research (IOR) and Oncology Institute of Southern Switzerland (IOSI) ; Bellinzona, Switzerland ; Faculty of Biology and Medicine; University of Lausanne ; Lausanne, Switzerland.

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http://www.tandfonline.com/doi/full/10.4161/2162402X.2014.99
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http://dx.doi.org/10.4161/2162402X.2014.994380DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4404842PMC
March 2015

Interaction of CDCP1 with HER2 enhances HER2-driven tumorigenesis and promotes trastuzumab resistance in breast cancer.

Cell Rep 2015 Apr 16;11(4):564-76. Epub 2015 Apr 16.

Institute of Oncology Research (IOR), Bellinzona 6500, Switzerland; Oncology Institute of Southern Switzerland (IOSI), Bellinzona 6500, Switzerland; Faculty of Biology and Medicine, University of Lausanne UNIL, Lausanne 1011, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2015.03.044DOI Listing
April 2015

Enhancing chemotherapy efficacy in Pten-deficient prostate tumors by activating the senescence-associated antitumor immunity.

Cell Rep 2014 Oct 25;9(1):75-89. Epub 2014 Sep 25.

Institute of Oncology Research (IOR) and Oncology Institute of Southern Switzerland (IOSI), Bellinzona 6500, Switzerland; Faculty of Biology and Medicine, University of Lausanne, UNIL, Rue du Bugnon 21, Lausanne 1011, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2014.08.044DOI Listing
October 2014

Tumour-infiltrating Gr-1+ myeloid cells antagonize senescence in cancer.

Nature 2014 Nov 24;515(7525):134-7. Epub 2014 Aug 24.

1] Institute of Oncology Research (IOR), Oncology Institute of Southern Switzerland, Bellinzona CH6500, Switzerland [2] Faculty of Biology and Medicine, University of Lausanne UNIL, Lausanne CH1011, Switzerland.

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http://dx.doi.org/10.1038/nature13638DOI Listing
November 2014

Coral aquaculture to support drug discovery.

Trends Biotechnol 2013 Oct 16;31(10):555-61. Epub 2013 Jul 16.

Departamento de Biologia and CESAM, University of Aveiro, Campus de Santiago, 3810-193, Aveiro, Portugal; Skidaway Institute of Oceanography, 10 Ocean Science Circle, Savannah, GA 31411, USA. Electronic address:

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http://dx.doi.org/10.1016/j.tibtech.2013.06.004DOI Listing
October 2013

Pro-senescence therapy for cancer treatment.

Nat Rev Cancer 2011 Jun 24;11(7):503-11. Epub 2011 Jun 24.

Cancer Genetics Program, Beth Israel Deaconess Cancer Center, Department of Medicine and Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston MA 02215, USA.

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http://dx.doi.org/10.1038/nrc3057DOI Listing
June 2011

Differential expression of S6K2 dictates tissue-specific requirement for S6K1 in mediating aberrant mTORC1 signaling and tumorigenesis.

Cancer Res 2011 May 28;71(10):3669-75. Epub 2011 Mar 28.

Cancer Genetics Program, Beth Israel Deaconess Cancer Center, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-10-3962DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3096749PMC
May 2011

PTEN level in tumor suppression: how much is too little?

Cancer Res 2011 Feb 25;71(3):629-33. Epub 2011 Jan 25.

Cancer Genetics Program, Beth Israel Deaconess Cancer Center, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-10-2488DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3249925PMC
February 2011

Viscosupplementation in the management of ankle osteoarthritis: a review.

Arch Orthop Trauma Surg 2011 Jan 10;131(1):139-47. Epub 2010 Aug 10.

Rheumatology, S.Pietro FBF Hospital, via Cassia 600, 00189 Rome, Italy.

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http://dx.doi.org/10.1007/s00402-010-1165-5DOI Listing
January 2011

Subtle variations in Pten dose determine cancer susceptibility.

Nat Genet 2010 May 18;42(5):454-8. Epub 2010 Apr 18.

Cancer Genetics Program, Department of Medicine, Beth Israel Deaconess Cancer Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.

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http://www.nature.com/articles/ng.556
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http://dx.doi.org/10.1038/ng.556DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3118559PMC
May 2010

A novel type of cellular senescence that can be enhanced in mouse models and human tumor xenografts to suppress prostate tumorigenesis.

J Clin Invest 2010 Mar 8;120(3):681-93. Epub 2010 Feb 8.

Cancer Genetics Program, Beth Israel Deaconess Cancer Center, Departments of Medicine and Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1172/JCI40535DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2827955PMC
March 2010

Differential p53-independent outcomes of p19(Arf) loss in oncogenesis.

Sci Signal 2009 Aug 18;2(84):ra44. Epub 2009 Aug 18.

Beth Israel Deaconess Cancer Center, Departments of Medicine and Pathology, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1126/scisignal.2000053DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2928478PMC
August 2009

ETS rearrangements and prostate cancer initiation.

Nature 2009 Feb;457(7231):E1; discussion E2-3

Cancer Biology and Genetics Program, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA.

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http://dx.doi.org/10.1038/nature07738DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2967456PMC
February 2009

Differential requirement of mTOR in postmitotic tissues and tumorigenesis.

Sci Signal 2009 Jan 27;2(55):ra2. Epub 2009 Jan 27.

Cancer Genetics Program, Beth Israel Deaconess Cancer Center, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1126/scisignal.2000189DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2906144PMC
January 2009

Aberrant Rheb-mediated mTORC1 activation and Pten haploinsufficiency are cooperative oncogenic events.

Genes Dev 2008 Aug;22(16):2172-7

Cancer Genetics Program, Beth Israel Deaconess Cancer Center, Department of Medicine and Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1101/gad.1699608DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2518820PMC
August 2008

NEDD4-1 is a proto-oncogenic ubiquitin ligase for PTEN.

Cell 2007 Jan;128(1):129-39

Cell Biology Program, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, Box 522, New York, NY 10021, USA.

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http://dx.doi.org/10.1016/j.cell.2006.11.039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1828909PMC
January 2007

PML inhibits HIF-1alpha translation and neoangiogenesis through repression of mTOR.

Nature 2006 Aug;442(7104):779-85

Cancer Biology and Genetics Program, Memorial Sloan-Kettering Cancer Center, Sloan-Kettering Institute, 1275 York Avenue, New York, New York 10021, USA.

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http://dx.doi.org/10.1038/nature05029DOI Listing
August 2006

Identification of a tumour suppressor network opposing nuclear Akt function.

Nature 2006 May 7;441(7092):523-7. Epub 2006 May 7.

Cancer Biology and Genetics Program, Memorial Sloan-Kettering Cancer Center, Sloan-Kettering Institute, 1275 York Avenue, New York, New York 10021, USA.

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http://dx.doi.org/10.1038/nature04809DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1976603PMC
May 2006

Nail disorders in a woman treated with ixabepilone for metastatic breast cancer.

Anticancer Res 2005 Sep-Oct;25(5):3531-2

Division of Medical Oncology A, Regina Elena Cancer Institute, Rome, Italy.

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October 2005

Open pilot study of ultrasound-guided intra-articular injection of hylan G-F 20 (Synvisc) in the treatment of symptomatic hip osteoarthritis.

Clin Rheumatol 2005 Jun 9;24(3):285-9. Epub 2004 Dec 9.

Department of Internal Medicine, S.Pietro-Fatebenefratelli Hospital, via Cassia 600 Centro ricerche "S.Pietro" AFaR, 00195, Rome, Italy.

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http://link.springer.com/10.1007/s10067-004-1009-1
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http://dx.doi.org/10.1007/s10067-004-1009-1DOI Listing
June 2005

New approaches to prevent intestinal toxicity of irinotecan-based regimens.

Cancer Treat Rev 2004 Oct;30(6):555-62

Division of Medical Oncology, San Pietro Hospital, FBF International, Rome, Italy.

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http://dx.doi.org/10.1016/j.ctrv.2004.05.002DOI Listing
October 2004

A man with a deltoid swelling and paraneoplastic erythrocytosis: case report.

Anticancer Res 2003 Nov-Dec;23(6D):5181-4

Department of Oncology, University of Rome La Sapienza, San Andrea Hospital, Via E. Chianesi 53, 00128 Rome, Italy.

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April 2004