Andrea Ablasser

Andrea Ablasser

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Andrea Ablasser

Andrea Ablasser

Publications by authors named "Andrea Ablasser"

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Regulation of cGAS- and RLR-mediated immunity to nucleic acids.

Nat Immunol 2020 Jan 9;21(1):17-29. Epub 2019 Dec 9.

Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1038/s41590-019-0556-1DOI Listing
January 2020

A carrier for cyclic dinucleotides.

Nat Immunol 2019 11;20(11):1418-1420

Global Health Institute, Swiss Federal Institute of Technology, Lausanne, Switzerland.

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http://dx.doi.org/10.1038/s41590-019-0521-zDOI Listing
November 2019

Virology: Poxins Soothe the STING.

Curr Biol 2019 05;29(9):R332-R334

Global Health Institute, Ecole Polytechnique Fédérale de Lausanne, 1015 Lausanne, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.cub.2019.03.031DOI Listing
May 2019

cGAS in action: Expanding roles in immunity and inflammation.

Science 2019 03;363(6431)

Howard Hughes Medical Institute, Department of Molecular Biology, Center for Inflammation Research, University of Texas Southwestern Medical Center, Dallas, TX 75390-9148, USA.

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http://www.sciencemag.org/lookup/doi/10.1126/science.aat8657
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http://dx.doi.org/10.1126/science.aat8657DOI Listing
March 2019

Innate immunosensing of DNA in cellular senescence.

Curr Opin Immunol 2019 02 5;56:31-36. Epub 2018 Oct 5.

Global Health Institute, Ecole Polytechnique Fédérale de Lausanne (EPFL), Switzerland. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S09527915183010
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http://dx.doi.org/10.1016/j.coi.2018.09.013DOI Listing
February 2019

Phase separation focuses DNA sensing.

Authors:
Andrea Ablasser

Science 2018 08;361(6403):646-647

Ecole Polytechnique Fédérale de Lausanne, 1015 Lausanne, Switzerland.

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http://dx.doi.org/10.1126/science.aau6019DOI Listing
August 2018

Human cGAS Has a Slightly Different Taste for dsDNA.

Immunity 2018 08;49(2):206-208

Global Health Institute, École Polytechnique Fédérale de Lausanne, 1015 Lausanne, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.immuni.2018.08.005DOI Listing
August 2018

Targeting STING with covalent small-molecule inhibitors.

Nature 2018 07 4;559(7713):269-273. Epub 2018 Jul 4.

Global Health Institute, Swiss Federal Institute of Technology Lausanne (EPFL), Lausanne, Switzerland.

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http://dx.doi.org/10.1038/s41586-018-0287-8DOI Listing
July 2018

Innate immune sensing of cytosolic chromatin fragments through cGAS promotes senescence.

Nat Cell Biol 2017 Sep 31;19(9):1061-1070. Epub 2017 Jul 31.

Global Health Institute, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland.

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http://www.nature.com/doifinder/10.1038/ncb3586
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http://dx.doi.org/10.1038/ncb3586DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5826565PMC
September 2017

Signalling strength determines proapoptotic functions of STING.

Nat Commun 2017 09 5;8(1):427. Epub 2017 Sep 5.

Global Health Institute, Ecole Polytechnique Fédérale de Lausanne (EPFL), Station 19, 1015, Lausanne, Switzerland.

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http://dx.doi.org/10.1038/s41467-017-00573-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5585373PMC
September 2017

Inflammasome Activation and Function During Infection with Mycobacterium Tuberculosis.

Curr Top Microbiol Immunol 2016;397:183-97

Max Planck Institute for Infection Biology, 10117, Berlin, Germany.

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http://link.springer.com/10.1007/978-3-319-41171-2_9
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http://dx.doi.org/10.1007/978-3-319-41171-2_9DOI Listing
June 2017

The role of cGAS in innate immunity and beyond.

J Mol Med (Berl) 2016 10 6;94(10):1085-1093. Epub 2016 May 6.

Global Health Institute, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015, Lausanne, Switzerland.

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http://dx.doi.org/10.1007/s00109-016-1423-2DOI Listing
October 2016

ReGLUation of cGAS.

Authors:
Andrea Ablasser

Nat Immunol 2016 Apr;17(4):347-9

Global Health Institute, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.

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http://www.nature.com/articles/ni.3397
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http://dx.doi.org/10.1038/ni.3397DOI Listing
April 2016

Inside Job: Viruses Transfer cGAMP between Cells.

Cell Host Microbe 2015 Sep;18(3):263-5

Global Health Institute, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.chom.2015.08.008DOI Listing
September 2015

Mycobacterium tuberculosis Differentially Activates cGAS- and Inflammasome-Dependent Intracellular Immune Responses through ESX-1.

Cell Host Microbe 2015 Jun 2;17(6):799-810. Epub 2015 Jun 2.

Global Health Institute, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.chom.2015.05.003DOI Listing
June 2015

OAS proteins and cGAS: unifying concepts in sensing and responding to cytosolic nucleic acids.

Nat Rev Immunol 2014 Aug 18;14(8):521-8. Epub 2014 Jul 18.

Department of Biochemistry and Gene Center, Ludwig-Maximilians-University, Feodor-Lynen-Strasse 25, D-81377 Munich, Germany.

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http://dx.doi.org/10.1038/nri3719DOI Listing
August 2014

TREX1 deficiency triggers cell-autonomous immunity in a cGAS-dependent manner.

J Immunol 2014 Jun 9;192(12):5993-7. Epub 2014 May 9.

Institute of Molecular Medicine, University Hospital, University of Bonn, 53127 Bonn, Germany; and

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http://dx.doi.org/10.4049/jimmunol.1400737DOI Listing
June 2014

Self-priming determines high type I IFN production by plasmacytoid dendritic cells.

Eur J Immunol 2014 Mar 16;44(3):807-818. Epub 2014 Jan 16.

Institute for Clinical Chemistry and Clinical Pharmacology, University Hospital, University of Bonn, 53105 Bonn, Germany.

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http://dx.doi.org/10.1002/eji.201343806DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4523003PMC
March 2014

Cell intrinsic immunity spreads to bystander cells via the intercellular transfer of cGAMP.

Nature 2013 Nov 29;503(7477):530-4. Epub 2013 Sep 29.

Institute for Clinical Chemistry and Clinical Pharmacology, University Hospital, University of Bonn, 53127 Bonn, Germany.

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http://dx.doi.org/10.1038/nature12640DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4142317PMC
November 2013

Nucleic acid driven sterile inflammation.

Clin Immunol 2013 Jun 19;147(3):207-15. Epub 2013 Jan 19.

Institute for Clinical Chemistry and Clinical Pharmacology, Unit for Clinical Biochemistry, University Hospital, University of Bonn, Germany.

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http://dx.doi.org/10.1016/j.clim.2013.01.003DOI Listing
June 2013

cGAS produces a 2'-5'-linked cyclic dinucleotide second messenger that activates STING.

Nature 2013 Jun 30;498(7454):380-4. Epub 2013 May 30.

Institute for Clinical Chemistry and Clinical Pharmacology, University Hospital, University of Bonn, 53127 Bonn, Germany.

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http://dx.doi.org/10.1038/nature12306DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4143541PMC
June 2013

Structural mechanism of cytosolic DNA sensing by cGAS.

Nature 2013 Jun 30;498(7454):332-7. Epub 2013 May 30.

Department of Biochemistry and Gene Center, Ludwig-Maximilians-University, 81377 Munich, Germany.

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http://dx.doi.org/10.1038/nature12305DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3768140PMC
June 2013

DNA sensing unchained.

Cell Res 2013 May 19;23(5):585-7. Epub 2013 Feb 19.

Institute for Clinical Chemistry and Pharmacology, Unit for Clinical Biochemistry, University Hospital, University of Bonn, Bonn, Germany.

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http://dx.doi.org/10.1038/cr.2013.28DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3641596PMC
May 2013

Species-specific detection of the antiviral small-molecule compound CMA by STING.

EMBO J 2013 May 19;32(10):1440-50. Epub 2013 Apr 19.

Unit for Clinical Biochemistry, Institute for Clinical Chemistry and Clinical Pharmacology, University Hospital, University of Bonn, Bonn, Germany.

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http://dx.doi.org/10.1038/emboj.2013.86DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3655471PMC
May 2013

Induction of type I IFNs by intracellular DNA-sensing pathways.

Immunol Cell Biol 2012 May 27;90(5):474-82. Epub 2012 Mar 27.

Institute for Clinical Chemistry and Clinical Pharmacology, Unit for Clinical Biochemistry, University Hospital, University of Bonn, Bonn, Germany.

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http://dx.doi.org/10.1038/icb.2012.11DOI Listing
May 2012

Where, in antiviral defense, does IFIT1 fit?

Nat Immunol 2011 Jun 20;12(7):588-90. Epub 2011 Jun 20.

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http://dx.doi.org/10.1038/ni.2061DOI Listing
June 2011

Inflammasomes: current understanding and open questions.

Cell Mol Life Sci 2011 Mar 31;68(5):765-83. Epub 2010 Oct 31.

Unit for Clinical Biochemistry, Institute for Clinical Chemistry and Clinical Pharmacology, University Hospital, University of Bonn, Sigmund-Freud-Strasse 25, Bonn, Germany.

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http://dx.doi.org/10.1007/s00018-010-0567-4DOI Listing
March 2011

An unexpected role for RNA in the recognition of DNA by the innate immune system.

RNA Biol 2010 Mar-Apr;7(2):151-7. Epub 2010 Mar 28.

Institute for Clinical Chemistry and Pharmacology, Unit for Clinical Biochemistry, University Hospital, University of Bonn, Bonn, Germany.

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http://dx.doi.org/10.4161/rna.7.2.11058DOI Listing
September 2010

Listeria monocytogenes is sensed by the NLRP3 and AIM2 inflammasome.

Eur J Immunol 2010 Jun;40(6):1545-51

Institute for Clinical Chemistry and Pharmacology, Unit for Clinical Biochemistry, University Hospital, University of Bonn, Bonn, Germany.

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http://dx.doi.org/10.1002/eji.201040425DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3128919PMC
June 2010

RIG-I-dependent sensing of poly(dA:dT) through the induction of an RNA polymerase III-transcribed RNA intermediate.

Nat Immunol 2009 Oct 16;10(10):1065-72. Epub 2009 Jul 16.

Institute for Clinical Chemistry and Pharmacology, University of Bonn, Bonn, Germany.

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http://dx.doi.org/10.1038/ni.1779DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3878616PMC
October 2009

TLR8-driven IL-12-dependent reciprocal and synergistic activation of NK cells and monocytes by immunostimulatory RNA.

J Immunother 2009 Apr;32(3):262-71

Division of Clinical Pharmacology, Department of Internal Medicine, Ludwig-Maximilians University of Munich, Germany.

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http://dx.doi.org/10.1097/CJI.0b013e318198bd2aDOI Listing
April 2009

AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC.

Nature 2009 Mar 21;458(7237):514-8. Epub 2009 Jan 21.

Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA.

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http://www.nature.com/doifinder/10.1038/nature07725
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http://dx.doi.org/10.1038/nature07725DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2726264PMC
March 2009

T cell-independent, TLR-induced IL-12p70 production in primary human monocytes.

J Immunol 2006 Jun;176(12):7438-46

Department of Internal Medicine, Division of Clinical Pharmacology, University of Munich, Germany.

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http://dx.doi.org/10.4049/jimmunol.176.12.7438DOI Listing
June 2006

Sequence-specific potent induction of IFN-alpha by short interfering RNA in plasmacytoid dendritic cells through TLR7.

Nat Med 2005 Mar 20;11(3):263-70. Epub 2005 Feb 20.

Department of Internal Medicine, Division of Clinical Pharmacology, Ludwig-Maximilians-University of Munich, Ziemssenstr. 1, 80336 München, Germany.

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http://www.nature.com/articles/nm1191
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http://dx.doi.org/10.1038/nm1191DOI Listing
March 2005