Publications by authors named "Andre Veillette"

92Publications

Critical Role of Lipid Scramblase TMEM16F in Phosphatidylserine Exposure and Repair of Plasma Membrane after Pore Formation.

Cell Rep 2020 01;30(4):1129-1140.e5

Laboratory of Molecular Oncology, Institut de Recherches Cliniques de Montréal (IRCM), Montréal, QC H2W1R7, Canada; Maisonneuve-Rosemont Hospital Research Center, Montréal, QC, Canada; Department of Medicine, McGill University, Montréal, QC H3G 1Y6, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2019.12.066DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7104872PMC
January 2020

[Loss of human ICOSLG results in combined immunodeficiency].

Med Sci (Paris) 2019 Aug-Sep;35(8-9):625-628. Epub 2019 Sep 18.

Le Programme en maladies infectieuses et immunité en santé mondiale, Centre universitaire de santé McGill, Institut de recherche, 1001 Decarie, H4A3J1 Montréal, Québec, Canada. - Laboratoire d'oncologie moléculaire, Institut de recherches cliniques de Montréal, Montréal, Québec, Canada. - Département de médecine, Université McGill, Montréal, Québec, Canada. - Département de médecine, Université de Montréal, Montréal, Québec, Canada.

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http://dx.doi.org/10.1051/medsci/2019126DOI Listing
April 2020

Introduction: Signaling and signal diversification in antigen-specific immune cells.

Authors:
André Veillette

Immunol Rev 2019 09;291(1):5-7

Laboratory of Molecular Oncology, Institut de recherches cliniques de Montréal (IRCM), Montréal, QC, Canada.

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http://dx.doi.org/10.1111/imr.12795DOI Listing
September 2019

SLAM receptors foster iNKT cell development by reducing TCR signal strength after positive selection.

Nat Immunol 2019 04 4;20(4):447-457. Epub 2019 Mar 4.

Laboratory of Molecular Oncology, Institut de recherches cliniques de Montréal, Montréal, Québec, Canada.

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http://dx.doi.org/10.1038/s41590-019-0334-0DOI Listing
April 2019

Signaling Regulatory Protein (SIRP)α-CD47 Blockade Joins the Ranks of Immune Checkpoint Inhibition.

J Clin Oncol 2019 04 27;37(12):1012-1014. Epub 2019 Feb 27.

1 Institut de Recherches Cliniques de Montréal, Montréal, Quebec, Canada.

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http://ascopubs.org/doi/10.1200/JCO.19.00121
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http://dx.doi.org/10.1200/JCO.19.00121DOI Listing
April 2019

Developing combination immunotherapies against cancer that make sense.

Sci Immunol 2018 11;3(29)

Laboratory of Molecular Oncology, Institut de Recherches Cliniques de Montréal (IRCM), Montréal, Québec H2W1R7, Canada.

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http://immunology.sciencemag.org/lookup/doi/10.1126/sciimmun
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http://dx.doi.org/10.1126/sciimmunol.aav1872DOI Listing
November 2018

It takes a village.

Nat Immunol 2018 10;19(10):1046-1047

Laboratory of Molecular Oncology, Institut de recherches cliniques de Montreal (IRCM), Montreal, Quebec, Canada.

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http://www.nature.com/articles/s41590-018-0213-0
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http://dx.doi.org/10.1038/s41590-018-0213-0DOI Listing
October 2018

SIRPα-CD47 Immune Checkpoint Blockade in Anticancer Therapy.

Trends Immunol 2018 03 11;39(3):173-184. Epub 2018 Jan 11.

Laboratory of Molecular Oncology, Institut de Recherches Cliniques de Montréal, Montréal, Québec H2W 1R7, Canada.

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http://dx.doi.org/10.1016/j.it.2017.12.005DOI Listing
March 2018

Two novel mutations in ZAP70 gene that result in human immunodeficiency.

Clin Immunol 2017 10 11;183:278-284. Epub 2017 Sep 11.

School of Medicine, Autonomous University of Morelos State, Mexico; Diagnostic and Molecular Medicine Unit "Dr. Ruy Pérez Tamayo", Morelos Children Hospital, Mexico. Electronic address:

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http://dx.doi.org/10.1016/j.clim.2017.09.005DOI Listing
October 2017

Morpholino-based correction of hypomorphic ZAP70 mutation in an adult with combined immunodeficiency.

J Allergy Clin Immunol 2017 05 17;139(5):1688-1692.e10. Epub 2017 Feb 17.

Infectious Disease Susceptibility Program, McGill University Health Centre (MUHC) and Research Institute-MUHC (RI-MUHC), Montreal, Quebec, Canada; Laboratory of Molecular Oncology, Institut de recherches cliniques de Montréal (IRCM), Montreal, Quebec, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2017.02.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7126384PMC
May 2017

The Csk-Associated Adaptor PAG Inhibits Effector T Cell Activation in Cooperation with Phosphatase PTPN22 and Dok Adaptors.

Cell Rep 2016 12;17(10):2776-2788

Laboratory of Molecular Oncology, Institut de recherches cliniques de Montréal, Montréal, QC H2W 1R7, Canada; Department of Medicine, University of Montréal, Montréal, QC H3C 3J7, Canada; Department of Medicine, McGill University, Montréal, QC H3G 1Y6, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2016.11.035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5656005PMC
December 2016

Deletion of Slam locus in mice reveals inhibitory role of SLAM family in NK cell responses regulated by cytokines and LFA-1.

J Exp Med 2016 09 29;213(10):2187-207. Epub 2016 Aug 29.

Laboratory of Molecular Oncology, Institut de recherches cliniques de Montréal, Montréal, Québec H2W 1R7, Canada Department of Medicine, McGill University, Montréal, Québec H3G 1Y6, Canada Department of Medicine, University of Montréal, Montréal, Québec H3T 1J4, Canada

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http://dx.doi.org/10.1084/jem.20160552DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5030809PMC
September 2016

SLAM-associated protein favors the development of iNKT2 over iNKT17 cells.

Eur J Immunol 2016 09 22;46(9):2162-74. Epub 2016 Jul 22.

Laboratory of Lymphocyte Activation and EBV Susceptibility, INSERM UMR 1163, Institut des Maladies Génétiques, Hôpital Necker-Enfants Malades, Paris, France.

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http://dx.doi.org/10.1002/eji.201646313DOI Listing
September 2016

Activation by SLAM Family Receptors Contributes to NK Cell Mediated "Missing-Self" Recognition.

PLoS One 2016 7;11(4):e0153236. Epub 2016 Apr 7.

Ludwig Center for Cancer Research, Department of Oncology, University of Lausanne, Epalinges, Switzerland.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0153236PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4824421PMC
September 2016

A hematopoietic cell-driven mechanism involving SLAMF6 receptor, SAP adaptors and SHP-1 phosphatase regulates NK cell education.

Nat Immunol 2016 Apr 15;17(4):387-96. Epub 2016 Feb 15.

Laboratory of Molecular Oncology, Institut de recherches cliniques de Montréal (IRCM), Montréal, Québec, Canada.

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http://www.nature.com/articles/ni.3369
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http://dx.doi.org/10.1038/ni.3369DOI Listing
April 2016

SLAM family receptors in normal immunity and immune pathologies.

Curr Opin Immunol 2016 Feb 2;38:45-51. Epub 2015 Dec 2.

Laboratory of Molecular Oncology, Institut de recherches cliniques de Montréal (IRCM), Montréal, Québec, Canada H2W 1R7; Department of Medicine, University of Montréal, Montréal, Québec, Canada H3T 1J4; Department of Medicine, McGill University, Montréal, Québec, Canada H3G 1Y6. Electronic address:

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http://dx.doi.org/10.1016/j.coi.2015.11.003DOI Listing
February 2016

DNAM-1 controls NK cell activation via an ITT-like motif.

J Exp Med 2015 Nov 9;212(12):2165-82. Epub 2015 Nov 9.

Laboratory of Molecular Oncology, Institut de recherches cliniques de Montréal, Montréal, Québec H2W 1R7, Canada Department of Medicine, McGill University, Montréal, Québec H3G 1Y6, Canada Department of Medicine, University of Montréal, Montréal, Québec H3T 1J4, Canada

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http://jem.rupress.org/content/212/12/2165.full.pdf
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http://www.jem.org/cgi/doi/10.1084/jem.20150792
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http://dx.doi.org/10.1084/jem.20150792DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4647266PMC
November 2015

Loss of PTPN12 Stimulates Progression of ErbB2-Dependent Breast Cancer by Enhancing Cell Survival, Migration, and Epithelial-to-Mesenchymal Transition.

Mol Cell Biol 2015 Dec 21;35(23):4069-82. Epub 2015 Sep 21.

Laboratory of Molecular Oncology, Clinical Research Institute of Montréal, Montréal, Québec, Canada Department of Medicine, McGill University, Montréal, Québec, Canada Department of Medicine, University of Montréal, Montréal, Québec, Canada

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http://dx.doi.org/10.1128/MCB.00741-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4628068PMC
December 2015

Mosaic partial deletion of PTPN12 in a child with interrupted aortic arch type A.

Am J Med Genet A 2015 Nov 6;167A(11):2674-83. Epub 2015 Aug 6.

Division of Genetics and Metabolism, Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota.

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http://dx.doi.org/10.1002/ajmg.a.37279DOI Listing
November 2015

A functional polymorphism of Ptpn22 is associated with type 1 diabetes in the BioBreeding rat.

J Immunol 2015 Jan 12;194(2):615-29. Epub 2014 Dec 12.

Department of Immunology, Faculty of Medicine, University of Toronto, Toronto, Ontario M5S 1A8, Canada; Biological Sciences Platform, Sunnybrook Research Institute, Toronto, Ontario M4N 3M5, Canada;

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http://dx.doi.org/10.4049/jimmunol.1302689DOI Listing
January 2015

Immune cell inhibition by SLAMF7 is mediated by a mechanism requiring src kinases, CD45, and SHIP-1 that is defective in multiple myeloma cells.

Mol Cell Biol 2015 Jan 13;35(1):41-51. Epub 2014 Oct 13.

Laboratory of Molecular Oncology, Clinical Research Institute of Montréal, Montréal, Québec, Canada Department of Medicine, McGill University, Montréal, Québec, Canada Department of Medicine, University of Montréal, Montréal, Québec, Canada

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http://dx.doi.org/10.1128/MCB.01107-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4295394PMC
January 2015

Immunology: When lymphocytes run out of steam.

Nature 2014 Jun 28;510(7504):222-3. Epub 2014 May 28.

Laboratory of Molecular Oncology, Institut de recherches cliniques de Montréal, Montreal, Quebec H2W1R7, Canada.

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http://dx.doi.org/10.1038/nature13346DOI Listing
June 2014

Control of dendritic cell migration, T cell-dependent immunity, and autoimmunity by protein tyrosine phosphatase PTPN12 expressed in dendritic cells.

Mol Cell Biol 2014 Mar 23;34(5):888-99. Epub 2013 Dec 23.

Laboratory of Molecular Oncology, Clinical Research Institute of Montréal, Montréal, Québec, Canada.

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http://mcb.asm.org/lookup/doi/10.1128/MCB.01369-13
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http://dx.doi.org/10.1128/MCB.01369-13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4023833PMC
March 2014

X-linked lymphoproliferative syndromes and related autosomal recessive disorders.

Curr Opin Allergy Clin Immunol 2013 Dec;13(6):614-22

aLaboratory of Molecular Oncology, Clinical Research Institute of Montréal bDepartment of Medicine, University of Montréal cDepartment of Medicine, McGill University, Montréal, Québec, Canada dUnité INSERM 768, Laboratoire du Développement Normal et Pathologique du Système Immunitaire, Hôpital Necker Enfants-Malades, Paris, France.

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http://dx.doi.org/10.1097/ACI.0000000000000008DOI Listing
December 2013

The adaptor molecule signaling lymphocytic activation molecule (SLAM)-associated protein (SAP) is essential in mechanisms involving the Fyn tyrosine kinase for induction and progression of collagen-induced arthritis.

J Biol Chem 2013 Nov 17;288(44):31423-36. Epub 2013 Sep 17.

From the Laboratory of Molecular Oncology, Clinical Research Institute of Montréal, Montréal, Québec H2W 1R7, Canada.

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http://dx.doi.org/10.1074/jbc.M113.473736DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3814739PMC
November 2013

CS1, a SLAM family receptor involved in immune regulation, is a therapeutic target in multiple myeloma.

Crit Rev Oncol Hematol 2013 Oct 2;88(1):168-77. Epub 2013 Jun 2.

Laboratory of Molecular Oncology, Institut de recherches cliniques de Montréal (IRCM), Montréal, Québec, Canada H2W 1R7; Department of Medicine, McGill University, Montréal, Québec, Canada H3G 1Y6; Department of Medicine, University of Montréal, Montréal, Québec, Canada H3T 1J4. Electronic address:

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http://dx.doi.org/10.1016/j.critrevonc.2013.04.003DOI Listing
October 2013

Macrophage fusion is controlled by the cytoplasmic protein tyrosine phosphatase PTP-PEST/PTPN12.

Mol Cell Biol 2013 Jun 15;33(12):2458-69. Epub 2013 Apr 15.

Laboratory of Molecular Oncology, Clinical Research Institute of Montréal, Montréal, Québec, Canada.

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http://dx.doi.org/10.1128/MCB.00197-13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3700098PMC
June 2013

Critical role of SAP in progression and reactivation but not maintenance of T cell-dependent humoral immunity.

Mol Cell Biol 2013 Mar 14;33(6):1223-32. Epub 2013 Jan 14.

Laboratory of Molecular Oncology, Clinical Research Institute of Montreal, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1128/MCB.01591-12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3592029PMC
March 2013

The adaptor SAP controls NK cell activation by regulating the enzymes Vav-1 and SHIP-1 and by enhancing conjugates with target cells.

Immunity 2012 Jun 7;36(6):974-85. Epub 2012 Jun 7.

Laboratory of Molecular Oncology, Clinical Research Institute of Montréal, Montréal, Québec, Canada.

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http://dx.doi.org/10.1016/j.immuni.2012.03.023DOI Listing
June 2012

Protein tyrosine phosphatases in lymphocyte activation and autoimmunity.

Nat Immunol 2012 Apr 18;13(5):439-47. Epub 2012 Apr 18.

Laboratory of Molecular Oncology, Clinical Research Institute of Montréal, Montréal, Québec, Canada.

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http://www.nature.com/articles/ni.2246
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http://dx.doi.org/10.1038/ni.2246DOI Listing
April 2012

Immunology: Csk keeps LYP on a leash.

Nat Chem Biol 2012 Apr 17;8(5):412-3. Epub 2012 Apr 17.

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http://www.nature.com/articles/nchembio.940
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http://dx.doi.org/10.1038/nchembio.940DOI Listing
April 2012

Redefining interferon-producing killer dendritic cells as a novel intermediate in NK-cell differentiation.

Blood 2012 May 21;119(19):4349-57. Epub 2012 Feb 21.

Department of Microbiology and Immunology, University of Montreal, and Maisonneuve-Rosemont Hospital Research Center, Montreal, QC.

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http://dx.doi.org/10.1182/blood-2011-11-395954DOI Listing
May 2012

Immunology: Magnesium in a signalling role.

Nature 2011 Jul 27;475(7357):462-3. Epub 2011 Jul 27.

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http://www.nature.com/articles/475462a
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http://dx.doi.org/10.1038/475462aDOI Listing
July 2011

The phosphatase PTP-PEST promotes secondary T cell responses by dephosphorylating the protein tyrosine kinase Pyk2.

Immunity 2010 Aug;33(2):167-80

Laboratory of Molecular Oncology, Clinical Research Institute of Montréal, Montréal, Québec H2W 1R7, Canada.

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http://dx.doi.org/10.1016/j.immuni.2010.08.001DOI Listing
August 2010

How do SAP family deficiencies compromise immunity?

Trends Immunol 2010 Aug 23;31(8):295-302. Epub 2010 Jul 23.

Clinical Research Institute of Montréal, Québec, Canada.

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http://dx.doi.org/10.1016/j.it.2010.05.008DOI Listing
August 2010

SLAM-family receptors: immune regulators with or without SAP-family adaptors.

Authors:
André Veillette

Cold Spring Harb Perspect Biol 2010 Mar;2(3):a002469

Laboratory of Molecular Oncology, Clinical Research Institute of Montréal, Montréal, Québec, Canada.

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http://dx.doi.org/10.1101/cshperspect.a002469DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2829957PMC
March 2010

Do NK cells always need a license to kill?

Nat Immunol 2010 Apr;11(4):279-80

Laboratory of Molecular Oncology, Clinical Research Institute of Montréal, Montréal, Québec, Canada.

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http://dx.doi.org/10.1038/ni0410-279DOI Listing
April 2010

Importance and mechanism of 'switch' function of SAP family adapters.

Immunol Rev 2009 Nov;232(1):229-39

Laboratory of Molecular Oncology, Clinical Research Institute of Montréal, Montréal, Québec, Canada.

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http://dx.doi.org/10.1111/j.1600-065X.2009.00824.xDOI Listing
November 2009

Organization of immunoreceptor signaling by adapters.

Authors:
André Veillette

Immunol Rev 2009 Nov;232(1):5-6

Clinical Research Institute of Montreal, Montreal, QC, Canada.

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http://doi.wiley.com/10.1111/j.1600-065X.2009.00847.x
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http://dx.doi.org/10.1111/j.1600-065X.2009.00847.xDOI Listing
November 2009

Essential function for SAP family adaptors in the surveillance of hematopoietic cells by natural killer cells.

Nat Immunol 2009 Sep 2;10(9):973-80. Epub 2009 Aug 2.

Laboratory of Molecular Oncology, Clinical Research Institute of Montréal, Montréal, Québec, Canada.

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http://www.nature.com/articles/ni.1763
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http://dx.doi.org/10.1038/ni.1763DOI Listing
September 2009

PEST family phosphatases in immunity, autoimmunity, and autoinflammatory disorders.

Immunol Rev 2009 Mar;228(1):312-24

Laboratory of Molecular Oncology, Clinical Research Institute of Montréal, Montréal, Québec, Canada.

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http://dx.doi.org/10.1111/j.1600-065X.2008.00747.xDOI Listing
March 2009

Influence of CRACC, a SLAM family receptor coupled to the adaptor EAT-2, on natural killer cell function.

Nat Immunol 2009 Mar 18;10(3):297-305. Epub 2009 Jan 18.

Laboratory of Molecular Oncology, Clinical Research Institute of Montréal, Montréal, Québec, Canada H2W 1R7.

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http://dx.doi.org/10.1038/ni.1693DOI Listing
March 2009

Lck-dependent Fyn activation requires C terminus-dependent targeting of kinase-active Lck to lipid rafts.

J Biol Chem 2008 Sep 27;283(39):26409-22. Epub 2008 Jul 27.

Sunnybrook Research Institute and the Department of Immunology, University of Toronto, Toronto, Ontario M4N 3M5, Canada.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M710372200
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http://dx.doi.org/10.1074/jbc.M710372200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3258908PMC
September 2008

Control of T lymphocyte signaling by Ly108, a signaling lymphocytic activation molecule family receptor implicated in autoimmunity.

J Biol Chem 2008 Jul 15;283(28):19255-64. Epub 2008 May 15.

Laboratory of Molecular Oncology, Clinical Research Institute of Montréal, Montréal, Québec H2W 1R7.

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http://dx.doi.org/10.1074/jbc.M800209200DOI Listing
July 2008

SAP expression in T cells, not in B cells, is required for humoral immunity.

Proc Natl Acad Sci U S A 2008 Jan 22;105(4):1273-8. Epub 2008 Jan 22.

Laboratory of Molecular Oncology, Clinical Research Institute of Montréal, Montréal, QC, Canada.

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http://www.pnas.org/cgi/doi/10.1073/pnas.0710698105
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http://dx.doi.org/10.1073/pnas.0710698105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2234128PMC
January 2008

Consequence of the SLAM-SAP signaling pathway in innate-like and conventional lymphocytes.

Immunity 2007 Nov;27(5):698-710

Laboratory of Molecular Oncology, Clinical Research Institute of Montréal, Montréal, Québec, Canada H2W 1R7.

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http://dx.doi.org/10.1016/j.immuni.2007.11.005DOI Listing
November 2007

PAG-associated FynT regulates calcium signaling and promotes anergy in T lymphocytes.

Mol Cell Biol 2007 Mar 8;27(5):1960-73. Epub 2007 Jan 8.

IRCM, 110 Pine Avenue West, Montréal, Québec, Canada.

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http://dx.doi.org/10.1128/MCB.01983-06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1820463PMC
March 2007

NK cell regulation by SLAM family receptors and SAP-related adapters.

Authors:
André Veillette

Immunol Rev 2006 Dec;214:22-34

Laboratory of Molecular Oncology, Clinical Research Institute of Montreal, Montréal, Québec, Canada.

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http://dx.doi.org/10.1111/j.1600-065X.2006.00453.xDOI Listing
December 2006

Association between SAP and FynT: Inducible SH3 domain-mediated interaction controlled by engagement of the SLAM receptor.

Mol Cell Biol 2006 Aug;26(15):5559-68

Laboratory of Molecular Oncology, Clinical Research Institute of Montreal, Montréal, Québec, Canada.

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http://dx.doi.org/10.1128/MCB.00357-06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1592776PMC
August 2006

SLAM family receptors and SAP-related adaptors: matters arising.

Trends Immunol 2006 May 3;27(5):228-34. Epub 2006 Apr 3.

Clinical Research Institute of Montreal, Montreal, Quebec, Canada H2W 1R7.

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http://dx.doi.org/10.1016/j.it.2006.03.003DOI Listing
May 2006

Immune regulation by SLAM family receptors and SAP-related adaptors.

Authors:
André Veillette

Nat Rev Immunol 2006 Jan;6(1):56-66

Clinical Research Institute of Montreal, 110 Pine Avenue West, Montreal, Quebec, H2W 1R7, Canada.

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http://www.nature.com/articles/nri1761
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http://dx.doi.org/10.1038/nri1761DOI Listing
January 2006

[EAT-2: a novel regulator of natural killer cell functions].

Med Sci (Paris) 2006 Jan;22(1):22-4

Institut de recherches cliniques de Montréal (IRCM), Québec, Canada.

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http://dx.doi.org/10.1051/medsci/200622122DOI Listing
January 2006

Protein tyrosine phosphatase alpha regulates Fyn activity and Cbp/PAG phosphorylation in thymocyte lipid rafts.

J Immunol 2005 Dec;175(12):7947-56

Department of Pediatrics, University of British Columbia, Vancouver, Canada.

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http://dx.doi.org/10.4049/jimmunol.175.12.7947DOI Listing
December 2005

Negative regulation of natural killer cell function by EAT-2, a SAP-related adaptor.

Nat Immunol 2005 Oct 28;6(10):1002-10. Epub 2005 Aug 28.

Clinical Research Institute of Montréal, Montréal, Québec H2W 1R7, Canada.

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http://www.nature.com/articles/ni1242
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http://dx.doi.org/10.1038/ni1242DOI Listing
October 2005

Regulation of natural cytotoxicity by the adaptor SAP and the Src-related kinase Fyn.

J Exp Med 2005 Jul;202(1):181-92

Laboratoire du Développement Normal et Pathologique du Système Immunitaire, Unité Institut National de la Santé et de la Recherche Medicale 429, Hôpital Necker Enfants-Malades, 75015 Paris, France.

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http://dx.doi.org/10.1084/jem.20050449DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2212903PMC
July 2005

The SAP family of adaptors in immune regulation.

Semin Immunol 2004 Dec;16(6):409-19

Unité INSERM U429, Hôpital Necker Enfants-Malades, 149 rue de Sèvres, 75015 Paris, France.

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http://dx.doi.org/10.1016/j.smim.2004.08.020DOI Listing
December 2004

Adaptors in immune regulation.

Authors:
André Veillette

Semin Immunol 2004 Dec;16(6):349

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http://dx.doi.org/10.1016/j.smim.2004.08.016DOI Listing
December 2004

Genetic evidence linking SAP, the X-linked lymphoproliferative gene product, to Src-related kinase FynT in T(H)2 cytokine regulation.

Immunity 2004 Nov;21(5):707-17

Laboratory of Molecular Oncology, Clinical Research Institute of Montreal, Montréal, Québec H2W 1R7, Canada.

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http://dx.doi.org/10.1016/j.immuni.2004.10.005DOI Listing
November 2004

Immune functions in mice lacking Clnk, an SLP-76-related adaptor expressed in a subset of immune cells.

Mol Cell Biol 2004 Jul;24(13):6067-75

Laboratory of Molecular Oncology, Clinical Research Institute of Montreal, Montréal, Québec, Canada H2W 1R7.

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http://dx.doi.org/10.1128/MCB.24.13.6067-6075.2004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC480883PMC
July 2004

Specialised adaptors in immune cells.

Authors:
André Veillette

Curr Opin Cell Biol 2004 Apr;16(2):146-55

Laboratory of Molecular Oncology, Clinical Research Institute of Montreal, 110 Pine Avenue West, Montreal, Quebec, Canada.

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http://linkinghub.elsevier.com/retrieve/pii/S095506740400006
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http://dx.doi.org/10.1016/j.ceb.2004.01.002DOI Listing
April 2004

SLAM Family Receptors Regulate Immunity with and without SAP-related Adaptors.

Authors:
André Veillette

J Exp Med 2004 May;199(9):1175-8

Laboratory of Molecular Oncology, Clinical Research Institute on Montreal, Québec, Canada.

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http://dx.doi.org/10.1084/jem.20040588DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2211906PMC
May 2004

Enrichment of lck in lipid rafts regulates colocalized fyn activation and the initiation of proximal signals through TCR alpha beta.

J Immunol 2004 Apr;172(7):4266-74

Sunnybrook and Women's College Health Sciences Center and Department of Immunology, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.4049/jimmunol.172.7.4266DOI Listing
April 2004

Inhibition of the Jun N-terminal protein kinase pathway by SHIP-1, a lipid phosphatase that interacts with the adaptor molecule Dok-3.

Mol Cell Biol 2004 Mar;24(6):2332-43

Laboratory of Molecular Oncology, Clinical Research Institute of Montreal, Montreal, Quebec, Canada H2W 1R7.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC355862PMC
http://dx.doi.org/10.1128/mcb.24.6.2332-2343.2004DOI Listing
March 2004

The SLAM family of immune-cell receptors.

Curr Opin Immunol 2003 Jun;15(3):277-85

Laboratory of Molecular Oncology, Clinical Research Institute of Montreal, Montréal, Québec, Canada.

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http://dx.doi.org/10.1016/s0952-7915(03)00041-4DOI Listing
June 2003

Regulation of Fyn through translocation of activated Lck into lipid rafts.

J Exp Med 2003 May;197(9):1221-7

Sunnybrook and Women's College Health Sciences Centre, and Departmentof Immunology, University of Toronto, Ontario M4N 3M5, Canada.

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http://dx.doi.org/10.1084/jem.20022112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193969PMC
May 2003

SAP: a molecular switch regulating the immune response through a unique signaling mechanism.

Authors:
André Veillette

Eur J Immunol 2003 May;33(5):1141-4

Laboratory of Molecular Oncology, IRCM and the Department of Medicine, University of Montréal, Québec, Canada.

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http://dx.doi.org/10.1002/eji.200323959DOI Listing
May 2003

Molecular and immunological basis of X-linked lymphoproliferative disease.

Immunol Rev 2003 Apr;192:212-24

Unité INSERM U429, Hôpital Necker Enfants-Malades, Paris, France.

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http://dx.doi.org/10.1034/j.1600-065x.2003.00023.xDOI Listing
April 2003

Phosphorylation-dependent regulation of T-cell activation by PAG/Cbp, a lipid raft-associated transmembrane adaptor.

Mol Cell Biol 2003 Mar;23(6):2017-28

Laboratory of Molecular Oncology, IRCM, 110 Pine Avenue West, Montréal, Québec, Canada H2W 1R7.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC149484PMC
http://dx.doi.org/10.1128/mcb.23.6.2017-2028.2003DOI Listing
March 2003

Binding of SAP SH2 domain to FynT SH3 domain reveals a novel mechanism of receptor signalling in immune regulation.

Nat Cell Biol 2003 Feb;5(2):149-54

Laboratory of Molecular Oncology, Clinical Research Institute of Montreal, Montréal, Québec, H2W 1R7, Canada.

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http://dx.doi.org/10.1038/ncb919DOI Listing
February 2003

Negative regulation of immunoreceptor signaling.

Annu Rev Immunol 2002 4;20:669-707. Epub 2001 Oct 4.

Laboratory of Molecular Oncology, IRCM, 110 Pine Avenue West, Montréal, Québec, Canada H2W 1R7.

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http://www.annualreviews.org/doi/10.1146/annurev.immunol.20.
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http://dx.doi.org/10.1146/annurev.immunol.20.081501.130710DOI Listing
June 2002

The SAP family: a new class of adaptor-like molecules that regulates immune cell functions.

Authors:
André Veillette

Sci STKE 2002 Feb 19;2002(120):pe8. Epub 2002 Feb 19.

Laboratory of Molecular Oncology, Institut de Recherches Cliniques de Montréal (IRCM), Montréal, Québec, Canada.

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http://dx.doi.org/10.1126/stke.2002.120.pe8DOI Listing
February 2002