Andre Richters

Andre Richters

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Andre Richters

Andre Richters

Publications by authors named "Andre Richters"

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23Publications

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An Array-Based Ligand Discovery Platform for Proteins With Short Half-Lives.

Methods Enzymol 2018 19;610:191-218. Epub 2018 Oct 19.

David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, United States; Center for Precision Cancer Medicine, Massachusetts Institute of Technology, Cambridge, MA, United States; The Broad Institute of MIT and Harvard, Cambridge, MA, United States; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, United States. Electronic address:

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http://dx.doi.org/10.1016/bs.mie.2018.09.019DOI Listing
June 2019

Targeting protein arginine methyltransferase 5 in disease.

Authors:
André Richters

Future Med Chem 2017 11 27;9(17):2081-2098. Epub 2017 Oct 27.

Department of Biological Engineering, David H Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.

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http://dx.doi.org/10.4155/fmc-2017-0089DOI Listing
November 2017

Phenotypic Identification of a Novel Autophagy Inhibitor Chemotype Targeting Lipid Kinase VPS34.

Angew Chem Int Ed Engl 2017 07 12;56(28):8153-8157. Epub 2017 Jun 12.

Faculty of Chemistry and Chemical Biology, TU Dortmund University, Otto-Hahn-Strasse 4a, 44227, Dortmund, Germany.

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http://dx.doi.org/10.1002/anie.201703738DOI Listing
July 2017

Epigenetic Modulation Using Small Molecules - Targeting Histone Acetyltransferases in Disease.

Curr Med Chem 2017 ;24(37):4121-4150

David H. Koch Institute for Integrative Cancer Research, Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, United States.

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http://www.eurekaselect.com/150387/article
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http://dx.doi.org/10.2174/0929867324666170223153115DOI Listing
January 2017

A cascade screening approach for the identification of Bcr-Abl myristate pocket binders active against wild type and T315I mutant.

Bioorg Med Chem Lett 2016 08 18;26(15):3436-40. Epub 2016 Jun 18.

Dipartimento di Farmacia, Università degli Studi di Genova, Viale Benedetto XV, 3, 16132 Genova, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2016.06.051DOI Listing
August 2016

Neuritogenic militarinone-inspired 4-hydroxypyridones target the stress pathway kinase MAP4K4.

Angew Chem Int Ed Engl 2015 Oct 23;54(42):12398-403. Epub 2015 Apr 23.

Max-Planck-Institut für Molekulare Physiologie, Abteilung Chemische Biologie, Otto-Hahn-Straße 11, 44227 Dortmund (Germany).

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http://dx.doi.org/10.1002/anie.201501515DOI Listing
October 2015

Covalent-Allosteric Kinase Inhibitors.

Angew Chem Int Ed Engl 2015 Aug 25;54(35):10313-6. Epub 2015 Jun 25.

Technische Universität Dortmund, Fakultät für Chemie und Chemische Biologie, Otto-Hahn-Strasse 6, 44227 Dortmund (Germany).

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http://dx.doi.org/10.1002/anie.201502142DOI Listing
August 2015

Structure-based design and synthesis of covalent-reversible inhibitors to overcome drug resistance in EGFR.

Bioorg Med Chem 2015 Jun 23;23(12):2767-80. Epub 2015 Apr 23.

Department of Chemistry and Chemical Biology, Technische Universität Dortmund, Otto-Hahn-Straße 6, 44227 Dortmund, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.bmc.2015.04.038DOI Listing
June 2015

Identification and further development of potent TBK1 inhibitors.

ACS Chem Biol 2015 Jan;10(1):289-98

Department of Chemistry and Chemical Biology, Technical University of Dortmund , Otto-Hahn-Straße 6, 44227 Dortmund, Germany.

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http://dx.doi.org/10.1021/cb500908dDOI Listing
January 2015

Identification of type II and III DDR2 inhibitors.

J Med Chem 2014 May 5;57(10):4252-62. Epub 2014 May 5.

Department of Chemistry and Chemical Biology, Technical University of Dortmund , Otto-Hahn-Straße 6, 44227 Dortmund, Germany.

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http://dx.doi.org/10.1021/jm500167qDOI Listing
May 2014

Cell-autonomous and non-cell-autonomous mechanisms of transformation by amplified FGFR1 in lung cancer.

Cancer Discov 2014 Feb 3;4(2):246-57. Epub 2013 Dec 3.

1Department of Translational Genomics, University of Cologne; 2Max-Planck-Institute for Neurological Research; Institutes of 3Pathology and 4Virology, University of Cologne;5Department I of Internal Medicine and Center for Integrated Oncology, University Hospital of Cologne; 6Blackfield AG, Cologne; 7Technical University Dortmund, Dortmund, Germany; 8Medical Oncology and 9Institute of Pathology, Cantonal Hospital, Luzern; 10Novartis Pharma AG, Basel, Switzerland; and 11Division of Natural Products Chemistry, CSIR-Indian Institute of Chemical Technology, Tarnaka, Hyderabad, India.

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http://cancerdiscovery.aacrjournals.org/cgi/doi/10.1158/2159
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http://dx.doi.org/10.1158/2159-8290.CD-13-0323DOI Listing
February 2014

Metabolically stable dibenzo[b,e]oxepin-11(6H)-ones as highly selective p38 MAP kinase inhibitors: optimizing anti-cytokine activity in human whole blood.

J Med Chem 2013 Nov 5;56(21):8561-78. Epub 2013 Nov 5.

Institute of Pharmacy , Department of Pharmaceutical and Medicinal Chemistry, Eberhard-Karls-University Tübingen , Auf der Morgenstelle 8, 72076 Tübingen, Germany.

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http://dx.doi.org/10.1021/jm401276hDOI Listing
November 2013

Targeting gain of function and resistance mutations in Abl and KIT by hybrid compound design.

J Med Chem 2013 Jul 10;56(14):5757-72. Epub 2013 Jul 10.

Department of Chemistry and Chemical Biology, Technical University of Dortmund, Otto-Hahn-Strasse 6, D-44227 Dortmund, Germany.

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http://dx.doi.org/10.1021/jm4004076DOI Listing
July 2013

De novo design of protein kinase inhibitors by in silico identification of hinge region-binding fragments.

ACS Chem Biol 2013 May 27;8(5):1044-52. Epub 2013 Mar 27.

Drug Discovery Unit (DDU), Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Sir James Black Centre, DD1 5EH, UK.

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http://pubs.acs.org/doi/10.1021/cb300729y
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http://dx.doi.org/10.1021/cb300729yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3833278PMC
May 2013

Targeting GSK3 from Ustilago maydis: type-II kinase inhibitors as potential antifungals.

ACS Chem Biol 2012 Jul 15;7(7):1257-67. Epub 2012 May 15.

Fakultät Chemie - Chemische Biologie, Technische Universität Dortmund, Germany.

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http://dx.doi.org/10.1021/cb300128bDOI Listing
July 2012

A chemical genetic approach for covalent inhibition of analogue-sensitive aurora kinase.

ACS Chem Biol 2012 Apr 1;7(4):723-31. Epub 2012 Feb 1.

Friedrich Miescher Laboratory of the Max Planck Society, Tübingen, Germany.

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http://dx.doi.org/10.1021/cb200465cDOI Listing
April 2012

Proteus in the world of proteins: conformational changes in protein kinases.

Arch Pharm (Weinheim) 2010 Apr;343(4):193-206

Chemical Genomics Centre of the Max Planck Society, Otto-Hahn-Strasse 15, D-44227 Dortmund, Germany.

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http://doi.wiley.com/10.1002/ardp.201000028
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http://dx.doi.org/10.1002/ardp.201000028DOI Listing
April 2010