Publications by authors named "Andre Richters"

26Publications

Modulating Androgen Receptor-Driven Transcription in Prostate Cancer with Selective CDK9 Inhibitors.

Cell Chem Biol 2020 Oct 20. Epub 2020 Oct 20.

David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02142, USA; MIT Center for Precision Cancer Medicine, Massachusetts Institute of Technology, Cambridge, MA 02142, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Electronic address:

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October 2020

Identification of cancer driver genes based on nucleotide context.

Nat Genet 2020 02 3;52(2):208-218. Epub 2020 Feb 3.

Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

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February 2020

An Array-Based Ligand Discovery Platform for Proteins With Short Half-Lives.

Methods Enzymol 2018 19;610:191-218. Epub 2018 Oct 19.

David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, United States; Center for Precision Cancer Medicine, Massachusetts Institute of Technology, Cambridge, MA, United States; The Broad Institute of MIT and Harvard, Cambridge, MA, United States; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, United States. Electronic address:

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June 2019

Targeting protein arginine methyltransferase 5 in disease.

Authors:
André Richters

Future Med Chem 2017 11 27;9(17):2081-2098. Epub 2017 Oct 27.

Department of Biological Engineering, David H Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.

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November 2017

Systematic Kinase Inhibitor Profiling Identifies CDK9 as a Synthetic Lethal Target in NUT Midline Carcinoma.

Cell Rep 2017 Sep;20(12):2833-2845

Molecular Pathology, Institute of Pathology, University of Cologne, Kerpener Str. 62, 50937 Cologne, Germany; Department of Translational Genomics, Medical Faculty, University of Cologne, Weyertal 115b, 50931 Cologne, Germany; Center for Molecular Medicine Cologne, University of Cologne, 50931 Cologne, Germany. Electronic address:

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September 2017

Epigenetic Modulation Using Small Molecules - Targeting Histone Acetyltransferases in Disease.

Curr Med Chem 2017 ;24(37):4121-4150

David H. Koch Institute for Integrative Cancer Research, Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, United States.

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January 2017

Corrigendum to "Structure-based design and synthesis of covalent-reversible inhibitors to overcome drug resistance in EGFR" [Bioorg. Med. Chem. 23, 2015, 2767-2780].

Bioorg Med Chem 2015 Aug 10;23(15):5075. Epub 2015 Jun 10.

Department of Chemistry and Chemical Biology, Technische Universität Dortmund, Otto-Hahn-Straße 6, 44227 Dortmund, Germany. Electronic address:

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August 2015

Covalent-Allosteric Kinase Inhibitors.

Angew Chem Int Ed Engl 2015 Aug 25;54(35):10313-6. Epub 2015 Jun 25.

Technische Universität Dortmund, Fakultät für Chemie und Chemische Biologie, Otto-Hahn-Strasse 6, 44227 Dortmund (Germany).

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August 2015

Structure-based design and synthesis of covalent-reversible inhibitors to overcome drug resistance in EGFR.

Bioorg Med Chem 2015 Jun 23;23(12):2767-80. Epub 2015 Apr 23.

Department of Chemistry and Chemical Biology, Technische Universität Dortmund, Otto-Hahn-Straße 6, 44227 Dortmund, Germany. Electronic address:

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June 2015

Neuritogenic militarinone-inspired 4-hydroxypyridones target the stress pathway kinase MAP4K4.

Angew Chem Int Ed Engl 2015 Oct 23;54(42):12398-403. Epub 2015 Apr 23.

Max-Planck-Institut für Molekulare Physiologie, Abteilung Chemische Biologie, Otto-Hahn-Straße 11, 44227 Dortmund (Germany).

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October 2015

Identification and further development of potent TBK1 inhibitors.

ACS Chem Biol 2015 Jan;10(1):289-98

Department of Chemistry and Chemical Biology, Technical University of Dortmund , Otto-Hahn-Straße 6, 44227 Dortmund, Germany.

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January 2015

Identification of type II and III DDR2 inhibitors.

J Med Chem 2014 May 5;57(10):4252-62. Epub 2014 May 5.

Department of Chemistry and Chemical Biology, Technical University of Dortmund , Otto-Hahn-Straße 6, 44227 Dortmund, Germany.

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May 2014

Cell-autonomous and non-cell-autonomous mechanisms of transformation by amplified FGFR1 in lung cancer.

Cancer Discov 2014 Feb 3;4(2):246-57. Epub 2013 Dec 3.

1Department of Translational Genomics, University of Cologne; 2Max-Planck-Institute for Neurological Research; Institutes of 3Pathology and 4Virology, University of Cologne;5Department I of Internal Medicine and Center for Integrated Oncology, University Hospital of Cologne; 6Blackfield AG, Cologne; 7Technical University Dortmund, Dortmund, Germany; 8Medical Oncology and 9Institute of Pathology, Cantonal Hospital, Luzern; 10Novartis Pharma AG, Basel, Switzerland; and 11Division of Natural Products Chemistry, CSIR-Indian Institute of Chemical Technology, Tarnaka, Hyderabad, India.

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February 2014

Metabolically stable dibenzo[b,e]oxepin-11(6H)-ones as highly selective p38 MAP kinase inhibitors: optimizing anti-cytokine activity in human whole blood.

J Med Chem 2013 Nov 5;56(21):8561-78. Epub 2013 Nov 5.

Institute of Pharmacy , Department of Pharmaceutical and Medicinal Chemistry, Eberhard-Karls-University Tübingen , Auf der Morgenstelle 8, 72076 Tübingen, Germany.

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November 2013

De novo design of protein kinase inhibitors by in silico identification of hinge region-binding fragments.

ACS Chem Biol 2013 May 27;8(5):1044-52. Epub 2013 Mar 27.

Drug Discovery Unit (DDU), Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Sir James Black Centre, DD1 5EH, UK.

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May 2013

A chemical genetic approach for covalent inhibition of analogue-sensitive aurora kinase.

ACS Chem Biol 2012 Apr 1;7(4):723-31. Epub 2012 Feb 1.

Friedrich Miescher Laboratory of the Max Planck Society, Tübingen, Germany.

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April 2012

Proteus in the world of proteins: conformational changes in protein kinases.

Arch Pharm (Weinheim) 2010 Apr;343(4):193-206

Chemical Genomics Centre of the Max Planck Society, Otto-Hahn-Strasse 15, D-44227 Dortmund, Germany.

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April 2010