Andre Pélegrin

Multimodal CEA-Targeted Image-Guided Colorectal Cancer Surgery using In-Labeled SGM-101.

Authors:

Jan Marie de Gooyer Fortuné M K Elekonawo Desirée L Bos Rachel S van der Post André Pèlegrin Bérénice Framery Françoise Cailler Alexander L Vahrmeijer Johannes H W de Wilt Mark Rijpkema

Clin Cancer Res 2020 Nov 8;26(22):5934-5942. Epub 2020 Sep 8.

Department of Radiology, Nuclear Medicine & Anatomy, Radboud University Medical Center, Nijmegen, Gelderland, the Netherlands.

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November 2020

Biasing human epidermal growth factor receptor 4 (HER4) tyrosine kinase signaling with antibodies: Induction of cell death by antibody-dependent HER4 intracellular domain trafficking.

Authors:

Romain Lanotte Véronique Garambois Nadège Gaborit Christel Larbouret Astrid Musnier Pierre Martineau André Pèlegrin Thierry Chardès

Cancer Sci 2020 Jul 8;111(7):2508-2525. Epub 2020 Jun 8.

Institut de Recherche en Cancérologie de Montpellier (IRCM), INSERM U1194, Université de Montpellier, Institut régional du Cancer de Montpellier (ICM), Montpellier, France.

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July 2020

Higher Anti-Tumor Efficacy of the Dual HER3-EGFR Antibody MEHD7945a Combined with Ionizing Irradiation in Cervical Cancer Cells.

Authors:

Laura Bourillon Sylvain Demontoy Alexis Lenglet Alexandre Zampieri Julien Fraisse Marta Jarlier Florence Boissière-Michot Hélène Perrochia Gauthier Rathat Véronique Garambois Nathalie Bonnefoy Henri-Alexandre Michaud Thierry Chardès Diego Tosi André Pèlegrin David Azria Christel Larbouret Céline Bourgier

Int J Radiat Oncol Biol Phys 2020 04 17;106(5):1039-1051. Epub 2020 Jan 17.

INSERM, U1194, IRCM, Univ Montpellier, Montpellier, France; Department of Radiation Oncology, ICM-Val d'Aurelle, Univ Montpellier, Montpellier, France. Electronic address:

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April 2020

[Players from the program "Investments for the Future": MAbImprove MabEx].

Authors:

Mélusine Larivière André Pèlegrin Pierre Martineau Hervé Watier

Med Sci (Paris) 2019 Dec 6;35(12):1204-1205. Epub 2020 Jan 6.

EA7501, Université de Tours, Tours, France - CHU de Tours, Tours, France.

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December 2019

[Antibodies, tools of choice for fluorescence-guided surgery].

Authors:

André Pèlegrin Marian Gutowski Françoise Cailler

Med Sci (Paris) 2019 Dec 6;35(12):1066-1071. Epub 2020 Jan 6.

SurgiMAb, 10 Parc Club du Millénaire, 1025 avenue Henri Becquerel, 34000 Montpellier, France.

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December 2019

[Radioimmunotherapy: the reasons for confidential clinical use and hope for development].

Authors:

Jacques Barbet Steven Le Gouill André Pèlegrin

Med Sci (Paris) 2019 Dec 6;35(12):1062-1065. Epub 2020 Jan 6.

IRCM, Institut de Recherche en Cancérologie de Montpellier, Inserm U1194, Université de Montpellier, Institut régional du Cancer de Montpellier, Montpellier, F-34298, France.

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December 2019

[A word from the coordinators].

Authors:

André Pèlegrin Alain Beck Hervé Watier

Med Sci (Paris) 2019 Dec 6;35(12):923. Epub 2020 Jan 6.

Coordinateur du LabEx MabImprove (PIA), et du programme Biomédicaments (Région Centre-Val de Loire), EA7501, Université de Tours, 37032 Tours Cedex, France CHRU de Tours, 37032 Tours Cedex, France.

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December 2019

Quantification of HER1, HER2 and HER3 by time-resolved Förster resonance energy transfer in FFPE triple-negative breast cancer samples.

Authors:

Alexandre Ho-Pun-Cheung Hervé Bazin Florence Boissière-Michot Caroline Mollevi Joëlle Simony-Lafontaine Emeline Landas Jean-Pierre Bleuse Thierry Chardès Jean-François Prost André Pèlegrin William Jacot Gérard Mathis Evelyne Lopez-Crapez

Br J Cancer 2020 02 3;122(3):397-404. Epub 2019 Dec 3.

ICM, Institut régional du Cancer de Montpellier, Montpellier, France.

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February 2020

ITCH-dependent proteasomal degradation of c-FLIP induced by the anti-HER3 antibody 9F7-F11 promotes DR5/caspase 8-mediated apoptosis of tumor cells.

Authors:

Christophe Le Clorennec Yassamine Lazrek Olivier Dubreuil Carla Sampaio Christel Larbouret Romain Lanotte Marie-Alix Poul Jean-Marc Barret Jean-François Prost André Pèlegrin Thierry Chardès

Cell Commun Signal 2019 08 23;17(1):106. Epub 2019 Aug 23.

Institut de Recherche en Cancérologie de Montpellier (IRCM), INSERM U1194, Université de Montpellier, Institut régional du Cancer de Montpellier (ICM), F-34298, Montpellier, France.

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August 2019

Quantitative proteomic analysis reveals AK2 as potential biomarker for late normal tissue radiotoxicity.

Authors:

Jérôme Lacombe Muriel Brengues Alain Mangé Céline Bourgier Sophie Gourgou André Pèlegrin Mahmut Ozsahin Jérôme Solassol David Azria

Radiat Oncol 2019 Aug 9;14(1):142. Epub 2019 Aug 9.

IRCM, INSERM, University Montpellier, ICM, Montpellier, France.

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August 2019

Toxicity and pharmacokinetic profile of SGM-101, a fluorescent anti-CEA chimeric antibody for fluorescence imaging of tumors in patients.

Authors:

Bérénice Framery Marian Gutowski Karen Dumas Alexandre Evrard Nathalie Muller Vincent Dubois Jérôme Quinonero François Scherninski André Pèlegrin Françoise Cailler

Toxicol Rep 2019 30;6:409-415. Epub 2019 Apr 30.

SurgiMAb, 10 Parc Club du Millénaire, 1025 Avenue Henri Becquerel, 34000, Montpellier, France.

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April 2019

Targets for MAbs: innovative approaches for their discovery & validation, LabEx MAbImprove 6 antibody industrial symposium, June 25-26, 2018, Montpellier, France.

Authors:

Pierre Martineau Hervé Watier Andre Pèlegrin Andrei Turtoi

MAbs 2019 07 16;11(5):812-825. Epub 2019 May 16.

a IRCM, Institut de Recherche en Cancérologie de Montpellier, INSERM U1194 , Université de Montpellier, Institut régional du Cancer de Montpellier , Montpellier , France.

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July 2019

An auristatin-based antibody-drug conjugate targeting HER3 enhances the radiation response in pancreatic cancer.

Authors:

Laura Bourillon Céline Bourgier Nadège Gaborit Véronique Garambois Eva Llès Alexandre Zampieri Charline Ogier Marta Jarlier Nina Radosevic-Robin Béatrice Orsetti Hélène Delpech Charles Theillet Pierre-Emmanuel Colombo David Azria André Pèlegrin Christel Larbouret Thierry Chardès

Int J Cancer 2019 10 1;145(7):1838-1851. Epub 2019 Apr 1.

Institut de Recherche en Cancérologie de Montpellier (IRCM), INSERM U1194, Université de Montpellier, Institut Régional du Cancer de Montpellier (ICM), 34298, Montpellier, France.

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October 2019

Immunotherapy of triple-negative breast cancer with cathepsin D-targeting antibodies.

J Immunother Cancer 2019 02 4;7(1):29. Epub 2019 Feb 4.

IRCM, INSERM, U1194 Univ Montpellier, ICM, 208, rue des Apothicaires, F-34298, Montpellier, Cedex 5, France.

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February 2019

A recycling anti-transferrin receptor-1 monoclonal antibody as an efficient therapy for erythroleukemia through target up-regulation and antibody-dependent cytotoxic effector functions.

Authors:

Madeline Neiveyans Rana Melhem Christophe Arnoult Thomas Bourquard Marta Jarlier Muriel Busson Adrien Laroche Martine Cerutti Martine Pugnière David Ternant Nadège Gaborit Thierry Chardès Anne Poupon Valérie Gouilleux-Gruart Andre Pèlegrin Marie-Alix Poul

MAbs 2019 04 18;11(3):593-605. Epub 2019 Feb 18.

a IRCM, Institut de Recherche en Cancérologie de Montpellier ; INSERM, U1194, Université de Montpellier, Montpellier , France.

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April 2019

Image-Guided Surgery in Patients with Pancreatic Cancer: First Results of a Clinical Trial Using SGM-101, a Novel Carcinoembryonic Antigen-Targeting, Near-Infrared Fluorescent Agent.

Authors:

Charlotte E S Hoogstins Leonora S F Boogerd Babs G Sibinga Mulder J Sven D Mieog Rutger Jan Swijnenburg Cornelis J H van de Velde Arantza Farina Sarasqueta Bert A Bonsing Berenice Framery André Pèlegrin Marian Gutowski Françoise Cailler Jacobus Burggraaf Alexander L Vahrmeijer

Ann Surg Oncol 2018 Oct 26;25(11):3350-3357. Epub 2018 Jul 26.

Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands.

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October 2018

Targeting the NRG1/HER3 pathway in tumor cells and cancer-associated fibroblasts with an anti-neuregulin 1 antibody inhibits tumor growth in pre-clinical models of pancreatic cancer.

Authors:

Charline Ogier Pierre-Emmanuel Colombo Corinne Bousquet Lucile Canterel-Thouennon Pierre Sicard Véronique Garambois Gaëlle Thomas Nadège Gaborit Marta Jarlier Nelly Pirot Martine Pugnière Nadia Vie Céline Gongora Pierre Martineau Bruno Robert André Pèlegrin Thierry Chardès Christel Larbouret

Cancer Lett 2018 09 20;432:227-236. Epub 2018 Jun 20.

IRCM, Institut de Recherche en Cancérologie de Montpellier, INSERM U1194, Université de Montpellier, Institut régional du Cancer de Montpellier, Montpellier, F-34298, France. Electronic address:

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September 2018

Safety and effectiveness of SGM-101, a fluorescent antibody targeting carcinoembryonic antigen, for intraoperative detection of colorectal cancer: a dose-escalation pilot study.

Lancet Gastroenterol Hepatol 2018 03 30;3(3):181-191. Epub 2018 Jan 30.

Department of Surgery, Leiden University Medical Center, Leiden, Netherlands. Electronic address:

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March 2018

The humanized anti-human AMHRII mAb 3C23K exerts an anti-tumor activity against human ovarian cancer through tumor-associated macrophages.

Authors:

Houcine Bougherara Fariba Némati André Nicolas Gérald Massonnet Martine Pugnière Charlotte Ngô Marie-Aude Le Frère-Belda Alexandra Leary Jérôme Alexandre Didier Meseure Jean-Marc Barret Isabelle Navarro-Teulon André Pèlegrin Sergio Roman-Roman Jean-François Prost Emmanuel Donnadieu Didier Decaudin

Oncotarget 2017 Nov 7;8(59):99950-99965. Epub 2017 Oct 7.

Laboratory of Preclinical Investigation, Translational Research Department, Institut Curie, PSL University, Paris, France.

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November 2017

Antibody-drug conjugates: Design and development for therapy and imaging in and beyond cancer, LabEx MAbImprove industrial workshop, July 27-28, 2017, Tours, France.

Authors:

Camille Martin Claire Kizlik-Masson André Pèlegrin Hervé Watier Marie-Claude Viaud-Massuard Nicolas Joubert

MAbs 2018 Feb/Mar;10(2):210-221. Epub 2018 Jan 9.

a Equipe 4 IMT GICC, Université François Rabelais , Tours , France.

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January 2019

SGM-101: An innovative near-infrared dye-antibody conjugate that targets CEA for fluorescence-guided surgery.

Authors:

Marian Gutowski Bérénice Framery Martin C Boonstra Véronique Garambois François Quenet Karen Dumas François Scherninski Françoise Cailler Alexander L Vahrmeijer André Pèlegrin

Surg Oncol 2017 Jun 9;26(2):153-162. Epub 2017 Mar 9.

Institut régional du Cancer de Montpellier, ICM, Montpellier, F-34298, France; IRCM, Institut de Recherche en Cancérologie de Montpellier, Montpellier, F-34298, France; INSERM, U1194, Montpellier, F-34298, France; Université de Montpellier, Montpellier, F-34298, France. Electronic address:

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June 2017

Neuregulin 1 Allosterically Enhances the Antitumor Effects of the Noncompeting Anti-HER3 Antibody 9F7-F11 by Increasing Its Binding to HER3.

Authors:

Christophe Le Clorennec Hervé Bazin Olivier Dubreuil Christel Larbouret Charline Ogier Yassamine Lazrek Véronique Garambois Marie-Alix Poul Philippe Mondon Jean-Marc Barret Gérard Mathis Jean-François Prost André Pèlegrin Thierry Chardès

Mol Cancer Ther 2017 07 15;16(7):1312-1323. Epub 2017 May 15.

IRCM, Institut de Recherche en Cancérologie de Montpellier, Montpellier, France.

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July 2017

The anti-tumor efficacy of 3C23K, a glyco-engineered humanized anti-MISRII antibody, in an ovarian cancer model is mainly mediated by engagement of immune effector cells.

Oncotarget 2017 Jun;8(23):37061-37079

IRCM, Institut de Recherche en Cancérologie de Montpellier, Montpellier, F-34298, France.

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June 2017

T lymphocytes to predict radiation-induced late effects in normal tissues.

Authors:

Muriel Brengues Ariane Lapierre Céline Bourgier André Pèlegrin Mahmut Özsahin David Azria

Expert Rev Mol Diagn 2017 02 22;17(2):119-127. Epub 2016 Dec 22.

a Immunotargeting and Radiobiology in Oncology , IRCM, Institut de Recherche en Cancérologie de Montpellier , Montpellier , France.

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February 2017

Therapeutic Activity of Anti-AXL Antibody against Triple-Negative Breast Cancer Patient-Derived Xenografts and Metastasis.

Authors:

Wilhem Leconet Myriam Chentouf Stanislas du Manoir Clément Chevalier Audrey Sirvent Imade Aït-Arsa Muriel Busson Marta Jarlier Nina Radosevic-Robin Charles Theillet Dany Chalbos Jean-Max Pasquet André Pèlegrin Christel Larbouret Bruno Robert

Clin Cancer Res 2017 Jun 6;23(11):2806-2816. Epub 2016 Dec 6.

IRCM-INSERM-U1194, Université de Montpellier, ICM, Montpellier, France.

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June 2017

Pregnane X-receptor promotes stem cell-mediated colon cancer relapse.

Oncotarget 2016 Aug;7(35):56558-56573

CNRS UMR5203, Institut de Génomique Fonctionnelle, Montpellier, France.

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August 2016

The anti-HER3 (ErbB3) therapeutic antibody 9F7-F11 induces HER3 ubiquitination and degradation in tumors through JNK1/2- dependent ITCH/AIP4 activation.

Authors:

Christophe Le Clorennec Yassamine Lazrek Olivier Dubreuil Christel Larbouret Marie-Alix Poul Philippe Mondon Gerry Melino André Pèlegrin Thierry Chardès

Oncotarget 2016 Jun;7(24):37013-37029

IRCM, Institut de Recherche en Cancérologie de Montpellier, Montpellier, F-34298, France.

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June 2016

Autocrine Secretion of Progastrin Promotes the Survival and Self-Renewal of Colon Cancer Stem-like Cells.

Cancer Res 2016 06 4;76(12):3618-28. Epub 2016 May 4.

CNRS, UMR-5203, Institut de Génomique Fonctionnelle, Montpellier, France. INSERM, U661, Montpellier, France. Universités de Montpellier 1 & 2, UMR-5203, Montpellier, France. Department of Pathology, The University of Melbourne, Parkville, Victoria, Australia.

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June 2016

Radiation-induced CD8 T-lymphocyte Apoptosis as a Predictor of Breast Fibrosis After Radiotherapy: Results of the Prospective Multicenter French Trial.

EBioMedicine 2015 Dec 25;2(12):1965-73. Epub 2015 Oct 25.

Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Switzerland.

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December 2015

Neutralization of KIT Oncogenic Signaling in Leukemia with Antibodies Targeting KIT Membrane Proximal Domain 5.

Authors:

Marianne Le Gall Ronan Crépin Madeline Neiveyans Christian Auclair Yongfeng Fan Yu Zhou James D Marks André Pèlegrin Marie-Alix Poul

Mol Cancer Ther 2015 Nov 10;14(11):2595-605. Epub 2015 Sep 10.

IRCM, Institut de Recherche en Cancérologie de Montpellier, Montpellier, France. INSERM, U1194, Montpellier, France. Université de Montpellier, Montpellier, France. Institut Régional du Cancer de Montpellier, Montpellier, France.

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November 2015

[The HER3/ERBB3 receptor: the dark side of the ERBB planet].

Authors:

Christel Larbouret Nadège Gaborit Marie-Alix Poul André Pèlegrin Thierry Chardès

Med Sci (Paris) 2015 May 9;31(5):465-8. Epub 2015 Jun 9.

IRCM, institut de recherche en cancérologie de Montpellier, 208, rue des Apothicaires, F-34298, Montpellier, France - Inserm U1194, F-34298, France - Université de Montpellier, Montpellier, F-34090, Montpellier, France - Institut régional du cancer de Montpellier, F-34298, Montpellier, France.

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May 2015

Dual targeting of HER1/EGFR and HER2 with cetuximab and trastuzumab in patients with metastatic pancreatic cancer after gemcitabine failure: results of the "THERAPY"phase 1-2 trial.

Authors:

Eric Assenat David Azria Caroline Mollevi Rosine Guimbaud Nicole Tubiana-Mathieu Denis Smith Jean-Pierre Delord Emmanuelle Samalin Fabienne Portales Christel Larbouret Bruno Robert Frédéric Bibeau Jean-Pierre Bleuse Evelyne Crapez Marc Ychou André Pèlegrin

Oncotarget 2015 May;6(14):12796-808

IRCM, Institut de Recherche en Cancérologie de Montpellier, Montpellier, France.

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May 2015

Examination of HER3 targeting in cancer using monoclonal antibodies.

Authors:

Nadège Gaborit Ali Abdul-Hai Maicol Mancini Moshit Lindzen Sara Lavi Orith Leitner Lucile Mounier Myriam Chentouf Sai Dunoyer Manjusha Ghosh Christel Larbouret Thierry Chardès Hervé Bazin André Pèlegrin Michael Sela Yosef Yarden

Proc Natl Acad Sci U S A 2015 Jan 6;112(3):839-44. Epub 2015 Jan 6.

Departments of Biological Regulation,

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January 2015

The human Müllerian inhibiting substance type II receptor as immunotherapy target for ovarian cancer. Validation using the mAb 12G4.

Authors:

Nathalie Kersual Véronique Garambois Thierry Chardès Jean-Pierre Pouget Imed Salhi Caroline Bascoul-Mollevi Frédéric Bibeau Muriel Busson Henri Vié Béatrice Clémenceau Christian K Behrens Pauline Estupina André Pèlegrin Isabelle Navarro-Teulon

MAbs 2014 ;6(5):1314-26

a IRCM; Institut de Recherche en Cancérologie de Montpellier ; Montpellier ; France.

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August 2015

Late side-effects after curative intent radiotherapy: Identification of hypersensitive patients for personalized strategy.

Authors:

Céline Bourgier Jérôme Lacombe Jérôme Solassol Alain Mange André Pèlegrin Mahmut Ozsahin David Azria

Crit Rev Oncol Hematol 2015 Mar 22;93(3):312-9. Epub 2014 Nov 22.

University of Montpellier I, Montpellier, France; Institut de Recherche en Cancérologie de Montpellier, Montpellier, France; Institut régional du Cancer de Montpellier (ICM) - Val d'Aurelle, Department of Radiotherapy, Montpellier, France.

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March 2015

HER3 as biomarker and therapeutic target in pancreatic cancer: new insights in pertuzumab therapy in preclinical models.

Authors:

Gaëlle Thomas Thierry Chardès Nadège Gaborit Caroline Mollevi Wilhem Leconet Bruno Robert Nina Radosevic-Robin Frédérique Penault-Llorca Céline Gongora Pierre-Emmanuel Colombo Yassamine Lazrek Rui Bras-Goncalves Ariel Savina David Azria Hervé Bazin André Pèlegrin Christel Larbouret

Oncotarget 2014 Aug;5(16):7138-48

IRCM, Institut de Recherche en Cancérologie de Montpellier, Montpellier, F-34298, France; INSERM, Unit 896, Montpellier, F-34298, France; Université Montpellier1, Montpellier, F-34298, France; ICM, Montpellier, France.

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August 2014

MAbImprove: a French "Laboratoire d'excellence" (LabEx) dedicated to therapeutic antibodies.

Authors:

André Pèlegrin Arnaud Daguet Hervé Watier

MAbs 2014 Jul-Aug;6(4):803-4. Epub 2014 May 16.

Université François Rabelais de Tours; CNRS, UMR 7292; Tours, France; CHRU de Tours; Service d'immunologie; Tours, France.

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February 2015

DNA damage-centered signaling pathways are effectively activated during low dose-rate Auger radioimmunotherapy.

Authors:

Bérengère Piron Salomé Paillas Vincent Boudousq André Pèlegrin Caroline Bascoul-Mollevi Nicolas Chouin Isabelle Navarro-Teulon Jean-Pierre Pouget

Nucl Med Biol 2014 May 6;41 Suppl:e75-83. Epub 2014 Feb 6.

IRCM, Institut de Recherche en Cancérologie de Montpellier, Montpellier, F-34298, France; INSERM, U896, Montpellier, F-34298, France; Université Montpellier 1, Montpellier, F-34298, France; Institut régional de Cancérologie de Montpellier, Montpellier, F-34298, France. Electronic address:

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May 2014

Peptides in receptor-mediated radiotherapy: from design to the clinical application in cancers.

Authors:

Catherine Lozza Isabelle Navarro-Teulon André Pèlegrin Jean-Pierre Pouget Eric Vivès

Front Oncol 2013 Sep 25;3:247. Epub 2013 Sep 25.

Institut de Recherche en Cancérologie de Montpellier , Montpellier , France ; INSERM, U896 , Montpellier , France ; Université Montpellier 1 , Montpellier , France ; Institut Régional du Cancer Montpellier , Montpellier , France.

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September 2013

Comparison between internalizing anti-HER2 mAbs and non-internalizing anti-CEA mAbs in alpha-radioimmunotherapy of small volume peritoneal carcinomatosis using 212Pb.

Authors:

Vincent Boudousq Laure Bobyk Muriel Busson Véronique Garambois Marta Jarlier Paraskevi Charalambatou André Pèlegrin Salomé Paillas Nicolas Chouin François Quenet Patrick Maquaire Julien Torgue Isabelle Navarro-Teulon Jean-Pierre Pouget

PLoS One 2013 29;8(7):e69613. Epub 2013 Jul 29.

Institut National de la Santé et de la Recherche Médicale U896, Université Montpellier, Montpellier, France.

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March 2014

Single-domain antibody-based and linker-free bispecific antibodies targeting FcγRIII induce potent antitumor activity without recruiting regulatory T cells.

Authors:

Caroline Rozan Amélie Cornillon Corinne Pétiard Martine Chartier Ghislaine Behar Charlotte Boix Brigitte Kerfelec Bruno Robert André Pèlegrin Patrick Chames Jean-Luc Teillaud Daniel Baty

Mol Cancer Ther 2013 Aug 11;12(8):1481-91. Epub 2013 Jun 11.

INSERM U1068, CRCM, France.

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August 2013

General overview of radioimmunotherapy of solid tumors.

Authors:

Isabelle Navarro-Teulon Catherine Lozza André Pèlegrin Eric Vivès Jean-Pierre Pouget

Immunotherapy 2013 May;5(5):467-87

IRCM, Institut de Recherche en Cancérologie de Montpellier, Montpellier, France.

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May 2013

Apoptosis and p53 are not involved in the anti-tumor efficacy of ¹²⁵I-labeled monoclonal antibodies targeting the cell membrane.

Authors:

Salomé Paillas Vincent Boudousq Bérengère Piron Nathalie Kersual Manuel Bardiès Nicolas Chouin Caroline Bascoul-Mollevi François-Xavier Arnaud André Pèlegrin Isabelle Navarro-Teulon Jean-Pierre Pouget

Nucl Med Biol 2013 May 19;40(4):471-80. Epub 2013 Mar 19.

IRCM, Institut de Recherche en Cancérologie de Montpellier, Montpellier, F-34298, France.

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May 2013

Anti-HER3 domain 1 and 3 antibodies reduce tumor growth by hindering HER2/HER3 dimerization and AKT-induced MDM2, XIAP, and FoxO1 phosphorylation.

Authors:

Yassamine Lazrek Olivier Dubreuil Véronique Garambois Nadège Gaborit Christel Larbouret Christophe Le Clorennec Gaelle Thomas Wilhem Leconet Marta Jarlier Martine Pugnière Nadia Vié Bruno Robert Céline Monnet Khalil Bouayadi Hakim Kharrat Philippe Mondon André Pèlegrin Thierry Chardès

Neoplasia 2013 Mar;15(3):335-47

Institut de Recherche en Cancérologie de Montpellier, INSERM Unit 896, Université Montpellier 1, CRLC Val d'Aurelle Paul Lamarque, Montpellier, France.

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March 2013

High level prokaryotic expression of anti-Müllerian inhibiting substance type II receptor diabody, a new recombinant antibody for in vivo ovarian cancer imaging.

Authors:

Céline Ortega Amaury Herbet Sophie Richard Nathalie Kersual Narciso Costa André Pèlegrin Frédéric Ducancel Jean-Yves Couraud Isabelle Navarro-Teulon Didier Boquet

J Immunol Methods 2013 Jan 14;387(1-2):11-20. Epub 2012 Aug 14.

CEA, iBiTecS, SPI, Laboratoire d'Ingénierie des Anticorps pour la Santé, Bt 136, CEA Saclay, F-91191 Gif sur Yvette, France.

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January 2013

Quantification of HER expression and dimerization in patients' tumor samples using time-resolved Förster resonance energy transfer.

Authors:

Alexandre Ho-Pun-Cheung Hervé Bazin Nadège Gaborit Christel Larbouret Patrick Garnero Eric Assenat Florence Castan Caroline Bascoul-Mollevi Jeanne Ramos Marc Ychou André Pèlegrin Gérard Mathis Evelyne Lopez-Crapez

PLoS One 2012 19;7(7):e37065. Epub 2012 Jul 19.

Translational Research Unit, CRLC Val d'Aurelle Paul Lamarque, Montpellier, France.

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December 2012

In pancreatic carcinoma, dual EGFR/HER2 targeting with cetuximab/trastuzumab is more effective than treatment with trastuzumab/erlotinib or lapatinib alone: implication of receptors' down-regulation and dimers' disruption.

Authors:

Christel Larbouret Nadège Gaborit Thierry Chardès Mickaël Coelho Emmanuelle Campigna Caroline Bascoul-Mollevi Jean-Pierre Mach David Azria Bruno Robert André Pèlegrin

Neoplasia 2012 Feb;14(2):121-30

Institut de Recherche en Cancérologie de Montpellier, Montpellier, France.

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February 2012

Clinical radioimmunotherapy--the role of radiobiology.

Authors:

Jean-Pierre Pouget Isabelle Navarro-Teulon Manuel Bardiès Nicolas Chouin Guillaume Cartron André Pèlegrin David Azria

Nat Rev Clin Oncol 2011 Nov 8;8(12):720-34. Epub 2011 Nov 8.

Direction de la Radioprotection de l'Homme, Institut de Radioprotection et de Sûreté Nucléaire, Fontenay-aux-Roses, F-92262, France.

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November 2011

CD4 ligation excludes the Carma1-Bcl10-MALT1 complex from GM1-positive membrane rafts in CD3/CD28 activated T cells.

Authors:

Maxime Rigo Myriam Chentouf André Pèlegrin Thierry Chardès

Cell Immunol 2011 29;270(1):40-6. Epub 2011 Mar 29.

IRCM, Institut de Recherche en Cancérologie de Montpellier, Montpellier F-34298, France.

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October 2011

Vaccination with human anti-trastuzumab anti-idiotype scFv reverses HER2 immunological tolerance and induces tumor immunity in MMTV.f.huHER2(Fo5) mice.

Authors:

Maha Z Ladjemi Thierry Chardes Stephanie Corgnac Veronique Garambois Sebastien Morisseau Bruno Robert Caroline Bascoul-Mollevi Imade Ait Arsa William Jacot Jean-Pierre Pouget Andre Pelegrin Isabelle Navarro-Teulon

Breast Cancer Res 2011 Feb 4;13(1):R17. Epub 2011 Feb 4.

IRCM, Institut de Recherche en Cancérologie de Montpellier, INSERM U896, Université Montpellier1, CRLC Val d'Aurelle Paul Lamarque, 208 rue des Apothicaires, Montpellier, F-34298, France.

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February 2011

Time-resolved fluorescence resonance energy transfer (TR-FRET) to analyze the disruption of EGFR/HER2 dimers: a new method to evaluate the efficiency of targeted therapy using monoclonal antibodies.

Authors:

Nadège Gaborit Christel Larbouret Julie Vallaghe Frédéric Peyrusson Caroline Bascoul-Mollevi Evelyne Crapez David Azria Thierry Chardès Marie-Alix Poul Gérard Mathis Hervé Bazin André Pèlegrin

J Biol Chem 2011 Apr 31;286(13):11337-45. Epub 2011 Jan 31.

IRCM, Institut de Recherche en Cancérologie de Montpellier, INSERM, U896, Université Montpellier1, CRLC Val d'Aurelle Paul Lamarque, Montpellier, France.

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April 2011

Brief intraperitoneal radioimmunotherapy of small peritoneal carcinomatosis using high activities of noninternalizing 125I-labeled monoclonal antibodies.

Authors:

Vincent Boudousq Stéphanie Ricaud Véronique Garambois Caroline Bascoul-Mollevi Samir Boutaleb Muriel Busson François Quenet Pierre-Emmanuel Colombo Manuel Bardiès Pierre-Olivier Kotzki Isabelle Navarro-Teulon André Pèlegrin Jean-Pierre Pouget

J Nucl Med 2010 Nov 18;51(11):1748-55. Epub 2010 Oct 18.

IRCM, Institut de Recherche en Cancérologie de Montpellier, Montpellier, France.

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November 2010

The lipid-modulating effects of a CD4-specific recombinant antibody correlate with ZAP-70 segregation outside membrane rafts.

Authors:

Myriam Chentouf Maxime Rigo Soufiane Ghannam Isabelle Navarro-Teulon Sébastien Mongrand André Pèlegrin Thierry Chardès

Immunol Lett 2010 Oct 24;133(2):62-9. Epub 2010 Jul 24.

IRCM, Institut de Recherche en Cancérologie de Montpellier, Montpellier F-34298, France.

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October 2010

Anti-HER2 vaccines: new prospects for breast cancer therapy.

Authors:

Maha Zohra Ladjemi William Jacot Thierry Chardès André Pèlegrin Isabelle Navarro-Teulon

Cancer Immunol Immunother 2010 Sep 8;59(9):1295-312. Epub 2010 Jun 8.

IRCM, Institut de Recherche en Cancérologie de Montpellier, INSERM U896, Université Montpellier1, Montpellier, France.

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September 2010

Cyclization of peptides through a urea bond: application to the Arg-Gly-Asp tripeptide.

Authors:

Julien Schmidt Véronique Garambois Luc Rocheblave Jean Martinez André Pèlegrin Florine Cavelier Eric Vivès

Chembiochem 2010 May;11(8):1083-92

Institut de Recherche en Cancérologie de Montpellier, Université Montpellier1, Montpellier, France.

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May 2010

Symplekin promotes tumorigenicity by up-regulating claudin-2 expression.

Authors:

Michael Buchert Marina Papin Caroline Bonnans Charbel Darido Warren S Raye Véronique Garambois André Pélegrin Jean-François Bourgaux Julie Pannequin Dominique Joubert Frédéric Hollande

Proc Natl Acad Sci U S A 2010 Feb 25;107(6):2628-33. Epub 2010 Jan 25.

Institut de Génomique Fonctionnelle, Centre National de la Recherche Scientifique, Unité Mixte de Recherche 5203, Institut National de la Santé et de la Recherche Médicale U661, and Université Montpellier 1 and 2, Montpellier F-34094, France.

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February 2010

[Bispecific antibodies: what future?].

Authors:

André Pèlegrin Bruno Robert

Med Sci (Paris) 2009 Dec;25(12):1155-8

Institut de recherche en cancérologie de Montpellier (IRCM), Montpellier, F-34298, France ; Inserm U896, Montpellier, F-34298, France.

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December 2009

Noninternalizing monoclonal antibodies are suitable candidates for 125I radioimmunotherapy of small-volume peritoneal carcinomatosis.

Authors:

Lore Santoro Samir Boutaleb Véronique Garambois Caroline Bascoul-Mollevi Vincent Boudousq Pierre-Olivier Kotzki Monique Pèlegrin Isabelle Navarro-Teulon André Pèlegrin Jean-Pierre Pouget

J Nucl Med 2009 Dec 12;50(12):2033-41. Epub 2009 Nov 12.

Institut de Recherche en Cancérologie de Montpellier, INSERM, U896, Montpellier, France.

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December 2009

Llama single-domain antibodies directed against nonconventional epitopes of tumor-associated carcinoembryonic antigen absent from nonspecific cross-reacting antigen.

Authors:

Ghislaine Behar Patrick Chames Isabelle Teulon Amélie Cornillon Faisal Alshoukr Françoise Roquet Martine Pugnière Jean-Luc Teillaud Anne Gruaz-Guyon André Pèlegrin Daniel Baty

FEBS J 2009 Jul 15;276(14):3881-93. Epub 2009 Jun 15.

CNRS, Laboratoire d'Ingénierie des Systèmes Macromoléculaires, Marseille, France.

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July 2009

A llama single domain anti-idiotypic antibody mimicking HER2 as a vaccine: Immunogenicity and efficacy.

Authors:

Nidia Alvarez-Rueda Maha Zohra Ladjemi Ghislaine Béhar Stéphanie Corgnac Martine Pugnière Françoise Roquet Caroline Bascoul-Mollevi Daniel Baty André Pèlegrin Isabelle Navarro-Teulon

Vaccine 2009 Jul 11;27(35):4826-33. Epub 2009 Jun 11.

IRCM (Institut de Recherche en Cancérologie de Montpellier), INSERM U896, Université Montpellier 1, CRLC Val d'Aurelle Paul Lamarque, Montpellier Cedex 5, France.

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July 2009

Single nucleotide polymorphisms, apoptosis, and the development of severe late adverse effects after radiotherapy.

Authors:

David Azria Mahmut Ozsahin Andrew Kramar Sheila Peters David P Atencio Nigel E A Crompton Françoise Mornex André Pèlegrin Jean-Bernard Dubois René-Olivier Mirimanoff Barry S Rosenstein

Clin Cancer Res 2008 Oct;14(19):6284-8

INSERM U896, Institut de Recherche en Cancérologie de Montpellier, Department of Radiation Oncology, CRLC Val d'Aurelle-Paul Lamarque, Montpellier, France.

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October 2008

Redirecting NK cells mediated tumor cell lysis by a new recombinant bifunctional protein.

Authors:

Claire Germain Emmanuelle Campigna Imed Salhi Sébastien Morisseau Isabelle Navarro-Teulon Jean-Pierre Mach André Pèlegrin Bruno Robert

Protein Eng Des Sel 2008 Nov 11;21(11):665-72. Epub 2008 Sep 11.

IRCM, Institut de Recherche en Cancérologie de Montpellier, INSERM U896, Université Montpellier1, Montpellier F-34298, France.

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November 2008

R-Cadherin expression inhibits myogenesis and induces myoblast transformation via Rac1 GTPase.

Authors:

Jérôme Kucharczak Sophie Charrasse Franck Comunale Jacques Zappulla Bruno Robert Isabelle Teulon-Navarro André Pèlegrin Cécile Gauthier-Rouvière

Cancer Res 2008 Aug;68(16):6559-68

CRBM, Université Montpellier 2 et 1, Centre National de la Recherche Scientifique UMR, France.

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August 2008

Cell membrane is a more sensitive target than cytoplasm to dense ionization produced by auger electrons.

Authors:

Jean-Pierre Pouget Lore Santoro Laure Raymond Nicolas Chouin Manuel Bardiès Caroline Bascoul-Mollevi Helena Huguet David Azria Pierre-Olivier Kotzki Monique Pèlegrin Eric Vivès André Pèlegrin

Radiat Res 2008 Aug;170(2):192-200

Direction de la Radioprotection de l'Homme, Institut de Radioprotection et de Sûreté Nucléaire, Fontenay-aux-Roses, France.

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August 2008

Adjuvant radioimmunotherapy trial with iodine-131-labeled anti-carcinoembryonic antigen monoclonal antibody F6 F(ab')2 after resection of liver metastases from colorectal cancer.

Authors:

Marc Ychou David Azria Cathy Menkarios Patrick Faurous François Quenet Bernard Saint-Aubert Philippe Rouanet Monique Pèlegrin Caroline Bascoul-Mollevi Dominique Guerreau Jean-Claude Saccavini Jean-Pierre Mach Jean-Claude Artus André Pèlegrin

Clin Cancer Res 2008 Jun;14(11):3487-93

Institut de Recherche en Cancérologie de Montpellier, CRLC Val d'Aurelle-Paul Lamarque, 34298 Montpellier Cedex 5, France.

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June 2008

Cell-penetrating and cell-targeting peptides in drug delivery.

Authors:

Eric Vivès Julien Schmidt André Pèlegrin

Biochim Biophys Acta 2008 Dec 9;1786(2):126-38. Epub 2008 Apr 9.

IRCM, Institut de Recherche en Cancérologie de Montpellier, Montpellier, F-34298, France.

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December 2008

Radiocurability by targeting tumor necrosis factor-alpha using a bispecific antibody in carcinoembryonic antigen transgenic mice.

Authors:

Christel Larbouret Bruno Robert Christine Linard Isabelle Teulon Sophie Gourgou Frederic Bibeau Pierre Martineau Lore Santoro Jean-Pierre Pouget Andre Pelegrin David Azria

Int J Radiat Oncol Biol Phys 2007 Nov;69(4):1231-7

INSERM, Centre de Recherche en Cancérologie de Montpellier, Université de Montpellier, CRLC Val d'Aurelle-Paul Lamarque, Montpellier, France.

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November 2007

[Combination of anti-EGFR and anti-HER2 antibodies: hope in pancreatic cancer treatment].

Authors:

Christel Larbouret Bruno Robert Isabelle Teulon Eric Assénat David Azria André Pèlegrin

Bull Cancer 2007 Oct;94(10):860-2

Centre de recherche en cancérologie de Montpellier (CRCM), Inserm U860 Immunociblage et radiobiologie en oncologie, Université Montpellier 1.

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October 2007

[Combined anti-EGFR and anti-HER2 monoclonal antibodies: preclinical efficacy in the treatment of pancreatic cancer].

Authors:

Christel Larbouret Bruno Robert Isabelle Teulon David Azria André Pèlegrin

Med Sci (Paris) 2007 Oct;23(10):800-3

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October 2007

Beta-catenin/Tcf-4 inhibition after progastrin targeting reduces growth and drives differentiation of intestinal tumors.

Authors:

Julie Pannequin Nathalie Delaunay Michael Buchert Fanny Surrel Jean-François Bourgaux Joanne Ryan Stéphanie Boireau Jessica Coelho André Pélegrin Pomila Singh Arthur Shulkes Mildred Yim Graham S Baldwin Christine Pignodel Gérard Lambeau Philippe Jay Dominique Joubert Frédéric Hollande

Gastroenterology 2007 Nov 24;133(5):1554-68. Epub 2007 Oct 24.

CNRS UMR5203, Montpellier, France.

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November 2007

In vivo therapeutic synergism of anti-epidermal growth factor receptor and anti-HER2 monoclonal antibodies against pancreatic carcinomas.

Authors:

Christel Larbouret Bruno Robert Isabelle Navarro-Teulon Simon Thèzenas Maha-Zohra Ladjemi Sébastien Morisseau Emmanuelle Campigna Frédéric Bibeau Jean-Pierre Mach André Pèlegrin David Azria

Clin Cancer Res 2007 Jun;13(11):3356-62

Institut National de la Santé et de la Reserche Médicale, EMI 0227, Centre de Recherche en cancérologie de Montpellier, Université Montpellier I, France.

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June 2007

MHC class I-related chain A conjugated to antitumor antibodies can sensitize tumor cells to specific lysis by natural killer cells.

Authors:

Claire Germain Christel Larbouret Valérie Cesson Alena Donda Werner Held Jean-Pierre Mach André Pèlegrin Bruno Robert

Clin Cancer Res 2005 Oct;11(20):7516-22

INSERM, EMI0227, Centre de Recherche en Cancérologie de Montpellier, Centre Régional de Lutte contre le Cancer Val d'Aurelle-Paul Lamarque, Montpellier, France.

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October 2005

Prognostic impact of epidermal growth factor receptor (EGFR) expression on loco-regional recurrence after preoperative radiotherapy in rectal cancer.

Authors:

David Azria Frederic Bibeau Nicolas Barbier Abderrahim Zouhair Claire Lemanski Philippe Rouanet Marc Ychou Pierre Senesse Mahmut Ozsahin André Pèlegrin Jean-Bernard Dubois Simon Thèzenas

BMC Cancer 2005 Jun 20;5:62. Epub 2005 Jun 20.

Department of Radiation Oncology, Val d'Aurelle Cancer Institute, Montpellier, France.

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June 2005

Radiation therapy and tamoxifen: concurrent or sequential? It's no longer the question!

Authors:

David Azria Andre Pelegrin Jean-Bernard Dubois Rene-Olivier Mirimanoff Mahmut Ozsahin

J Clin Oncol 2005 Jun;23(18):4239-41; author reply 4241-2

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June 2005

A labeled neutral endopeptidase inhibitor as a potential tool for tumor diagnosis and prognosis.

Authors:

Olivier Raguin Marie-Claude Fournié-Zaluski Anthony Romieu André Pèlegrin François Chatelet Didier Pélaprat Jacques Barbet Bernard P Roques Anne Gruaz-Guyon

Angew Chem Int Ed Engl 2005 Jun;44(26):4058-61

EA 3512, Faculté de Médecine Xavier Bichat, BP416, 16 rue Henri Huchard, 75870 Paris cedex 18, France.

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June 2005

Letrozole sensitizes breast cancer cells to ionizing radiation.

Authors:

David Azria Christel Larbouret Severine Cunat Mahmut Ozsahin Sophie Gourgou Pierre Martineau Dean B Evans Gilles Romieu Pascal Pujol Andre Pèlegrin

Breast Cancer Res 2005 7;7(1):R156-63. Epub 2004 Dec 7.

Department of Radiation Oncology, CRLC Val d'Aurelle, Montpellier, France.

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January 2006

Fully human IgG and IgM antibodies directed against the carcinoembryonic antigen (CEA) Gold 4 epitope and designed for radioimmunotherapy (RIT) of colorectal cancers.

Authors:

Véronique Garambois Fabienne Glaussel Elodie Foulquier Marc Ychou Martine Pugnière Robin X Luo Binyam Bezabeh André Pèlegrin

BMC Cancer 2004 Oct 15;4:75. Epub 2004 Oct 15.

INSERM, EMI0227 Centre de Recherche en Cancérologie, CRLC Val d'Aurelle-Paul Lamarque, F-34298 Cedex 5 Montpellier, France.

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October 2004

[Bioluminescent imaging: applications to cancerology and endocrinology].

Authors:

Arnaud Pillon Philippe Gauthier Patrick Balaguer André Pélegrin Jean-Claude Nicolas

J Soc Biol 2004 ;198(2):157-61

INSERM Unité 540, Endocrinologie Moléculaire et Cellulaire des Cancers, 60, rue de Navacelles, 34090 Montpellier.

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December 2004

[Radiotherapy and inhibitors of epidermal growth factor receptor: preclinical findings and preliminary clinical trials].

Authors:

David Azria Christel Larbouret Bruno Robert Stéphane Culine Marc Ychou Pierre Verrelle Jean-Bernard Dubois André Pèlegrin

Bull Cancer 2003 Nov;90 Spec No:S202-12

Département d'oncologie-radiothérapie, Laboratoire d'immunociblage des tumeurs et ingénierie des anticorps, EMI 0227, CRLC Val-d'Aurelle-Paul-Lamarque, 34298 Montpellier.

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November 2003

A bispecific antibody to enhance radiotherapy by tumor necrosis factor-alpha in human CEA-expressing digestive tumors.

Authors:

David Azria Christel Larbouret Veronique Garambois Sophie Gourgou Pierre Martineau Bruno Robert Jean-Bernard Dubois Andre Pelegrin

Int J Radiat Oncol Biol Phys 2004 Feb;58(2):580-8

Tumor Immunotargeting and Antibody Engineering, INSERM EMI 0227, 34298 Montpellier Cedex 5, France.

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February 2004

The anti-Müllerian hormone type II receptor: insights into the binding domains recognized by a monoclonal antibody and the natural ligand.

Authors:

Imed Salhi Sylvie Cambon-Roques Isabelle Lamarre Daniel Laune Franck Molina Martine Pugnière Didier Pourquier Marian Gutowski Jean-Yves Picard Françoise Xavier André Pèlegrin Isabelle Navarro-Teulon

Biochem J 2004 May;379(Pt 3):785-93

EMI 0227 INSERM/Université Montpellier I/CRLC Montpellier, Cancer Institute Val d'Aurelle-Paul Lamarque, 35 rue de la Croix Verte, 34298 Montpellier Cedex 5, France.

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May 2004

Targeting of human breast cancer by a bispecific antibody directed against two tumour-associated antigens: ErbB-2 and carcinoembryonic antigen.

Authors:

Mylène Dorvillius Vèronique Garambois Didier Pourquier Marian Gutowski Philippe Rouanet Jean-Claude Mani Martine Pugnière Nancy E Hynes André Pèlegrin

Tumour Biol 2002 Nov-Dec;23(6):337-47

EMI 0227 INSERM and GDR CNRS 2352, Université Montpellier I, Cancer Research Centre, Montpellier, France.

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August 2003

Enhancement of radiation therapy by tumor necrosis factor alpha in human colon cancer using a bispecific antibody.

Authors:

David Azria Mylène Dorvillius Sophie Gourgou Pierre Martineau Bruno Robert Martine Pugnière René Delard Marc Ychou Jean-Bernard Dubois André Pèlegrin

Int J Radiat Oncol Biol Phys 2003 Apr;55(5):1363-73

INSERM EMI0227 Tumor Biology and Antibody Engineering, CNRS GDR2352, Marseille, Montpellier, France.

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April 2003

Pharmacokinetic and tumor-seeking properties of recombinant and nonrecombinant anti-carcinoembryonic antigen antibody fragments.

Authors:

Agnès Groulet Mylène Dorvillius André Pèlegrin Jacques Barbet Daniel Baty

Int J Cancer 2002 Jul;100(3):367-74

Institut de Biologie Structurale et Microbiologie, Marseille, France.

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July 2002

Improved tumor selectivity of radiolabeled peptides by receptor and antigen dual targeting in the neurotensin receptor model.

Authors:

Marc Hillairet De Boisferon Olivier Raguin Cynthia Thiercelin Monique Dussaillant William Rostène Jacques Barbet André Pélegrin Anne Gruaz-Guyon

Bioconjug Chem 2002 May-Jun;13(3):654-62

INSERM U339, Faculté de Médecine et Hôpital Saint-Antoine, Paris, France.

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December 2002

Publications by authors named "Andre Pélegrin"

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