André O von Bueren

André O von Bueren

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André O von Bueren

André O von Bueren

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Comment on: Ketogenic diet treatment in recurrent diffuse intrinsic pontine glioma in children: A safety and feasibility study.

Pediatr Blood Cancer 2019 Jul 15;66(7):e27664. Epub 2019 Feb 15.

Department of Pediatrics, Obstetrics and Gynecology, Division of Pediatric Hematology and Oncology, University Hospital of Geneva, Geneva, Switzerland.

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http://dx.doi.org/10.1002/pbc.27664DOI Listing
July 2019

Brainstem biopsy in pediatric diffuse intrinsic pontine glioma in the era of precision medicine: the INFORM study experience.

Eur J Cancer 2019 Jun 22;114:27-35. Epub 2019 Apr 22.

Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany; Department of Pediatric Oncology, Hematology & Immunology, Heidelberg University Hospital, Heidelberg, Germany; Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S09598049193022
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http://dx.doi.org/10.1016/j.ejca.2019.03.019DOI Listing
June 2019

Occurrence of high-grade glioma in Noonan syndrome: Report of two cases.

Pediatr Blood Cancer 2019 05 28;66(5):e27625. Epub 2019 Jan 28.

Division of Pediatric Hematology and Oncology, Department of Pediatrics and Adolescent Medicine, University Hospital of Geneva, Geneva, Switzerland.

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http://dx.doi.org/10.1002/pbc.27625DOI Listing
May 2019

Diffuse intrinsic pontine gliomas (DIPG) at recurrence: is there a window to test new therapies in some patients?

J Neurooncol 2018 Sep 17;139(2):501. Epub 2018 Apr 17.

Geneva University Hospitals, Geneva, Switzerland.

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http://dx.doi.org/10.1007/s11060-018-2871-zDOI Listing
September 2018

Clinical, Radiologic, Pathologic, and Molecular Characteristics of Long-Term Survivors of Diffuse Intrinsic Pontine Glioma (DIPG): A Collaborative Report From the International and European Society for Pediatric Oncology DIPG Registries.

J Clin Oncol 2018 07 10;36(19):1963-1972. Epub 2018 May 10.

Lindsey M. Hoffman and Nicholas K. Foreman, University of Colorado Denver; Lindsey M. Hoffman and Nicholas K. Foreman, Children's Hospital Colorado, Aurora, CO; Sophie E.M. Veldhuijzen van Zanten, Esther Hulleman, Gertjan J.L. Kaspers, Esther Sanchez, and Dannis G. van Vuurden, Vrije Universiteit University Medical Center, Amsterdam; William P. Vandertop, Academy of Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands; Niclas Colditz, Marion Hoffmann, Brigitte Bison, Monika Warmuth-Metz, and Christof M. Kramm, University Medical Center Goettingen, Goettingen; Torsten Pietsch and Gerrit H. Gielen, University of Bonn Medical Center, Bonn; David T.W. Jones, Dominik Sturm, Stefan M. Pfister, and Elke Pfaff, German Cancer Research Center, Hopp-Children's Cancer Center at the Nationale Centrum für Tumorerkrankungen Heidelberg, and German Consortium for Translational Cancer Research; Dominik Sturm, Stefan M. Pfister, and Elke Pfaff, Heidelberg University Hospital, Heidelberg, Germany; Joshua Baugh, Brooklyn Chaney, Adam Lane, Christine Fuller, Nancy Yanez Escorza, Renee Doughman, Rachid Drissi, James Leach, Blaise Jones, and Maryam Fouladi, Cincinnati Children's Hospital Medical Center, Cincinnati; Emmett Broxson, Wright State University and The Children's Medical Center, Dayton, OH; Lili Miles, Nemours Children's Hospital, Orlando, FL; Cynthia Hawkins, Ute Bartels, and Eric Bouffet, The Hospital for Sick Children, Toronto, Ontario; Anne Sophie Carret, Centre Hospitalier Universitaire Sainte-Justine; Nada Jabado, McGill University, Montreal, Quebec, Canada; Stewart Goldman, Ann and Robert H Lurie Children's Hospital of Chicago, Chicago, IL; Sarah Leary, Seattle Children's Hospital, University of Washington and Fred Hutchinson Cancer Research Center, Seattle, WA; Roger Packer, Children's National Health System; Javad Nazarian, Children's National Medical Center, Washington, DC; Katherine E. Warren, National Cancer Institute, Bethesda, MD; Alberto Broniscer, St Jude Children's Research Hospital, Memphis, TN; Mark W. Kieran, Dana-Farber Boston Children's Cancer and Blood Disorders Center, Boston, MA; Jane Minturn, Children's Hospital of Philadelphia and The Perelman School of Medicine at the University of Pennsylvania, Philadelphia; Melanie Comito, The Pennsylvania State University, Hershey, PA; Chie-Schin Shih, Indiana University, Indianapolis, IN; Soumen Khatua, The University of Texas MD Anderson Cancer Center; Murali Chintagumpala, Texas Children's Cancer and Hematology Centers, Baylor College of Medicine, Houston, TX; Timothy Hassall, Lady Cilento Children's Hospital, Brisbane, Queensland; David S. Ziegler, Kids Cancer Centre, Sydney Children's Hospital, Randwick; David S. Ziegler, University of New South Wales, Sydney, New South Wales; Nicholas Gottardo and Hetal Dholaria, Princess Margaret Hospital for Children, Perth, Western Australia, Australia; Martin Benesch, Medical University of Graz, Graz, Austria; Nathalie Boddaert. Stephanie Puget, and Raphaël Calmon, Hôpital Necker Enfants Malades; Pascale Varlet, Hôpital Sainte-Anne, Université Paris V Descartes, Sorbonne Paris Cité, Paris; Géraldine Giraud, David Castel, and Jacques Grill, Gustave Roussy, Université Paris-Sud, Université Paris-Saclay, Villejuif, France; Géraldine Giraud, Uppsala University, Uppsala, Sweden; Chris Jones, The Institute of Cancer Research, Sutton; Darren Hargrave, Great Ormond Street Hospital, London; Guirish A. Solanki, Birmingham Women's and Children's Hospital, Birmingham; Simon Bailey, Great North Children's Hospital, Victoria Wing, Royal Victoria Infirmary, Newcastle upon Tyne, United Kingdom; Piergiorgio Modena and Marzia Giagnacovo, Sant' Anna Como General Hospital, Como; Manila Antonelli, Sapienza University of Rome, Rome; Veronica Biassoni and Maura Massimino, Fondazione Istituto Di Ricovero e Cura a Carattere Scientifico, Istituto Nazionale dei Tumori, Milan, Italy; Nicolas U. Gerber and Michael A. Grotzer, University Children's Hospital of Zurich, Zurich; André O. von Bueren, University Hospital of Geneva and University of Geneva, Geneva, Switzerland; and Filip Jadrijevic Cvrlje and Gertjan J.L. Kaspers, Children's Hospital Zagreb, Zagreb, Croatia.

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http://dx.doi.org/10.1200/JCO.2017.75.9308DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6075859PMC
July 2018

Concurrent and Mutations in Pediatric Medulloblastoma: A Case Report.

Front Neurol 2018 19;9:398. Epub 2018 Jun 19.

Division of Pediatric Hematology and Oncology, Department of Pediatrics and Adolescent Medicine, Geneva University Hospitals (HUG), Geneva, Switzerland.

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http://dx.doi.org/10.3389/fneur.2018.00398DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6018091PMC
June 2018

High-grade glioma in very young children: a rare and particular patient population.

Oncotarget 2017 Sep 14;8(38):64564-64578. Epub 2017 Jun 14.

Department of Pediatrics and Adolescent Medicine, Division of Pediatric Hematology and Oncology, University Hospital of Geneva, Geneva, Switzerland.

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http://dx.doi.org/10.18632/oncotarget.18478DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5610026PMC
September 2017

Haematological malignancies following temozolomide treatment for paediatric high-grade glioma.

Eur J Cancer 2017 08 3;81:1-8. Epub 2017 Jun 3.

Division of Pediatric Hematology and Oncology, Department of Child and Adolescent Health, University Medical Center Göttingen, Göttingen, Germany.

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http://dx.doi.org/10.1016/j.ejca.2017.04.023DOI Listing
August 2017

Development of the SIOPE DIPG network, registry and imaging repository: a collaborative effort to optimize research into a rare and lethal disease.

J Neurooncol 2017 04 21;132(2):255-266. Epub 2017 Jan 21.

Department of Paediatrics, Division of Oncology/Haematology, VU University Medical Center, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1007/s11060-016-2363-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5378734PMC
April 2017

Childhood cancer predisposition syndromes-A concise review and recommendations by the Cancer Predisposition Working Group of the Society for Pediatric Oncology and Hematology.

Am J Med Genet A 2017 Apr 7;173(4):1017-1037. Epub 2017 Feb 7.

Pediatric Hematology and Oncology, Hannover Medical School, Hannover, Germany.

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http://dx.doi.org/10.1002/ajmg.a.38142DOI Listing
April 2017

Reverse phase protein arrays enable glioblastoma molecular subtyping.

J Neurooncol 2017 02 17;131(3):437-448. Epub 2016 Nov 17.

Department of Neurosurgery, University Hospital Basel, Spitalstrasse 21, 4031, Basel, Switzerland.

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http://dx.doi.org/10.1007/s11060-016-2316-5DOI Listing
February 2017

Treatment of Children and Adolescents With Metastatic Medulloblastoma and Prognostic Relevance of Clinical and Biologic Parameters.

J Clin Oncol 2016 12 31;34(34):4151-4160. Epub 2016 Oct 31.

André O. von Bueren, Katja von Hoff, Carsten Friedrich, Martin Mynarek, and Stefan Rutkowski, University Medical Center Hamburg-Eppendorf, Hamburg; André O. von Bueren, University Medical Center Goettingen, Goettingen; Rolf-Dieter Kortmann and Klaus Müller, University of Leipzig; Carsten Friedrich, University Hospital Leipzig, Leipzig; Katja von Hoff, Nicolas Gerber, Monika Warmuth-Metz, Niels Soerensen, Frank Deinlein, and Joachim Kuehl, University of Wuerzburg, Wuerzburg; Tobias Goschzik, Anja zur Mühlen, and Torsten Pietsch, University of Bonn Medical Center; Udo Bode, University Hospital of Bonn, Bonn; Isabella Zwiener and Andreas Faldum, University Medical Center of the Johannes Gutenberg University of Mainz, Mainz; Robert Kwiecien and Andreas Faldum, University of Muenster, Muenster; Gudrun Fleischhack, University Hospital of Essen, Essen; Volker Hovestadt, Marcel Kool, David Jones, Paul Northcott, and Stefan Pfister, German Cancer Research Center; Marcel Kool, David Jones, Paul Northcott, and Stefan Pfister, German Cancer Consortium; Stefan Pfister, University Hospital and National Center for Tumor Diseases, Heidelberg, Germany; Nicolas Gerber, University Children's Hospital, Zurich, Switzerland; Martin Benesch, Medical University of Graz, Graz, Austria; and Paul Northcott, St Jude Children's Research Hospital, Memphis, TN.

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http://dx.doi.org/10.1200/JCO.2016.67.2428DOI Listing
December 2016

Secondary Solid Malignancies After High-Grade Glioma Treatment in Pediatric Patients.

Pediatr Hematol Oncol 2015 3;32(7):467-73. Epub 2015 Aug 3.

b Division of Pediatric Hematology and Oncology, Department of Child and Adolescent Health , University Medical Center Göttingen , Göttingen, Germany.

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http://dx.doi.org/10.3109/08880018.2015.1050615DOI Listing
September 2016

Next-generation personalised medicine for high-risk paediatric cancer patients - The INFORM pilot study.

Eur J Cancer 2016 09 29;65:91-101. Epub 2016 Jul 29.

Department of Pediatric Oncology, Hematology & Immunology, Heidelberg University Hospital, Im Neuenheimer Feld 430, Heidelberg, 69120, Germany; German Cancer Consortium (DKTK), Im Neuenheimer Feld 280, Heidelberg, 69120, Germany; Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg, 69120, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.ejca.2016.06.009DOI Listing
September 2016

Comment on: Adjuvant chemotherapy in adult medulloblastoma: is it an option for average-risk patients?

J Neurooncol 2016 08 9;129(1):189-91. Epub 2016 Jun 9.

University Medical Center Leipzig, Leipzig, Germany.

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http://dx.doi.org/10.1007/s11060-016-2159-0DOI Listing
August 2016

External validation of a prognostic model estimating the survival of patients with recurrent high-grade gliomas after reirradiation.

Pract Radiat Oncol 2015 May-Jun;5(3):e143-50. Epub 2014 Nov 18.

Department of Radiation Oncology (MAASTRO), GROW (School for Oncology & Developmental Biology), Maastricht University Medical Centre, Maastricht, The Netherlands; Department of Radiation Oncology, MediClin Robert Janker Clinic & University of Bonn Med Centre, Clinical Cooperation Unit Neurooncology, Bonn, Germany.

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http://dx.doi.org/10.1016/j.prro.2014.10.001DOI Listing
April 2016

Epidermal growth factor receptor overexpression is common and not correlated to gene copy number in ependymoma.

Childs Nerv Syst 2016 Feb 21;32(2):281-90. Epub 2015 Dec 21.

Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, D-20246, Hamburg, Germany.

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http://dx.doi.org/10.1007/s00381-015-2981-2DOI Listing
February 2016

New Brain Tumor Entities Emerge from Molecular Classification of CNS-PNETs.

Authors:
Dominik Sturm Brent A Orr Umut H Toprak Volker Hovestadt David T W Jones David Capper Martin Sill Ivo Buchhalter Paul A Northcott Irina Leis Marina Ryzhova Christian Koelsche Elke Pfaff Sariah J Allen Gnanaprakash Balasubramanian Barbara C Worst Kristian W Pajtler Sebastian Brabetz Pascal D Johann Felix Sahm Jüri Reimand Alan Mackay Diana M Carvalho Marc Remke Joanna J Phillips Arie Perry Cynthia Cowdrey Rachid Drissi Maryam Fouladi Felice Giangaspero Maria Łastowska Wiesława Grajkowska Wolfram Scheurlen Torsten Pietsch Christian Hagel Johannes Gojo Daniela Lötsch Walter Berger Irene Slavc Christine Haberler Anne Jouvet Stefan Holm Silvia Hofer Marco Prinz Catherine Keohane Iris Fried Christian Mawrin David Scheie Bret C Mobley Matthew J Schniederjan Mariarita Santi Anna M Buccoliero Sonika Dahiya Christof M Kramm André O von Bueren Katja von Hoff Stefan Rutkowski Christel Herold-Mende Michael C Frühwald Till Milde Martin Hasselblatt Pieter Wesseling Jochen Rößler Ulrich Schüller Martin Ebinger Jens Schittenhelm Stephan Frank Rainer Grobholz Istvan Vajtai Volkmar Hans Reinhard Schneppenheim Karel Zitterbart V Peter Collins Eleonora Aronica Pascale Varlet Stephanie Puget Christelle Dufour Jacques Grill Dominique Figarella-Branger Marietta Wolter Martin U Schuhmann Tarek Shalaby Michael Grotzer Timothy van Meter Camelia-Maria Monoranu Jörg Felsberg Guido Reifenberger Matija Snuderl Lynn Ann Forrester Jan Koster Rogier Versteeg Richard Volckmann Peter van Sluis Stephan Wolf Tom Mikkelsen Amar Gajjar Kenneth Aldape Andrew S Moore Michael D Taylor Chris Jones Nada Jabado Matthias A Karajannis Roland Eils Matthias Schlesner Peter Lichter Andreas von Deimling Stefan M Pfister David W Ellison Andrey Korshunov Marcel Kool

Cell 2016 Feb;164(5):1060-1072

Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), 69120 Heidelberg, Germany.

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http://www.cell.com/cell/pdf/S0092-8674(16)00055-6.pdf
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http://www.cell.com/cms/attachment/2048488015/2058390163/mmc
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http://linkinghub.elsevier.com/retrieve/pii/S009286741600055
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http://dx.doi.org/10.1016/j.cell.2016.01.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5139621PMC
February 2016

Metastatic medulloblastoma in adults: outcome of patients treated according to the HIT2000 protocol.

Eur J Cancer 2015 Nov 5;51(16):2434-43. Epub 2015 Aug 5.

Department of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Germany.

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http://dx.doi.org/10.1016/j.ejca.2015.06.124DOI Listing
November 2015

Primitive neuroectodermal tumors of the brainstem in children treated according to the HIT trials: clinical findings of a rare disease.

J Neurosurg Pediatr 2015 Mar 2;15(3):227-35. Epub 2015 Jan 2.

Department of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg;

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http://dx.doi.org/10.3171/2014.9.PEDS14213DOI Listing
March 2015

Adults with CNS primitive neuroectodermal tumors/pineoblastomas: results of multimodal treatment according to the pediatric HIT 2000 protocol.

J Neurooncol 2014 Feb 10;116(3):567-75. Epub 2014 Jan 10.

Department of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Martinistr. 52, 20246, Hamburg, Germany.

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http://dx.doi.org/10.1007/s11060-013-1327-8DOI Listing
February 2014

Supra- and infratentorial pediatric ependymomas differ significantly in NeuN, p75 and GFAP expression.

J Neurooncol 2013 Apr 31;112(2):191-7. Epub 2013 Jan 31.

Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, Martinistr. 52, 20246, Hamburg, Germany.

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http://dx.doi.org/10.1007/s11060-013-1062-1DOI Listing
April 2013

DNA copy number alterations in central primitive neuroectodermal tumors and tumors of the pineal region: an international individual patient data meta-analysis.

J Neurooncol 2012 Sep 7;109(2):415-23. Epub 2012 Jul 7.

Department of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246, Hamburg, Germany.

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http://dx.doi.org/10.1007/s11060-012-0911-7DOI Listing
September 2012

CNS PNET molecular subgroups with distinct clinical features.

Lancet Oncol 2012 Aug 11;13(8):753-4. Epub 2012 Jun 11.

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http://dx.doi.org/10.1016/S1470-2045(12)70260-7DOI Listing
August 2012

Dissecting the genomic complexity underlying medulloblastoma.

Nature 2012 Aug;488(7409):100-5

Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany.

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http://dx.doi.org/10.1038/nature11284DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3662966PMC
August 2012

p53 expression predicts dismal outcome for medulloblastoma patients with metastatic disease.

J Neurooncol 2012 Jan 28;106(1):135-41. Epub 2011 Jul 28.

Institute of Neuropathology, University of Bonn Medical Center, Sigmund-Freud-Strasse 25, 53127 Bonn, Germany.

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http://link.springer.com/10.1007/s11060-011-0648-8
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http://dx.doi.org/10.1007/s11060-011-0648-8DOI Listing
January 2012

Expression of FoxM1 is required for the proliferation of medulloblastoma cells and indicates worse survival of patients.

Clin Cancer Res 2011 Nov 14;17(21):6791-801. Epub 2011 Sep 14.

Center for Neuropathology, Ludwig-Maximilians-University, Munich, Germany.

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http://dx.doi.org/10.1158/1078-0432.CCR-11-1214DOI Listing
November 2011

Primary central nervous system primitive neuroectodermal tumors (CNS-PNETs) of the spinal cord in children: four cases from the German HIT database with a critical review of the literature.

J Neurooncol 2011 Aug 22;104(1):279-86. Epub 2010 Dec 22.

Division of Pediatric Hematology and Oncology, Department of Pediatrics and Adolescent Medicine, Medical University of Graz, Auenbruggerplatz 8, 8036 Graz, Austria.

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http://dx.doi.org/10.1007/s11060-010-0485-1DOI Listing
August 2011

Recurrence in childhood medulloblastoma.

J Neurooncol 2011 Jul 11;103(3):705-11. Epub 2010 Nov 11.

Department of Neuroradiology, Reference Center for Neuroradiology, University of Würzburg, Josef-Schneider-Str.11, 97080 Würzburg, Germany.

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http://link.springer.com/10.1007/s11060-010-0452-x
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http://dx.doi.org/10.1007/s11060-010-0452-xDOI Listing
July 2011

Expression of O⁶-methylguanine-DNA methyltransferase in childhood medulloblastoma.

J Neurooncol 2011 May 5;103(1):59-69. Epub 2010 Sep 5.

Neuro-Oncology Program, University Children's Hospital, Steinwiesstrasse 75, 8032 Zurich, Switzerland.

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http://dx.doi.org/10.1007/s11060-010-0366-7DOI Listing
May 2011

Acquired vorinostat resistance shows partial cross-resistance to 'second-generation' HDAC inhibitors and correlates with loss of histone acetylation and apoptosis but not with altered HDAC and HAT activities.

Anticancer Drugs 2009 Jun;20(5):321-33

Department of Gynecology, University Hospital Zurich bDivision of Oncology, University Children's Hospital Zurich, Zurich, Switzerland.

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http://dx.doi.org/10.1097/CAD.0b013e3283262a32DOI Listing
June 2009

Temperature sensitivity of phospho-Ser(473)-PKB/AKT.

Biochem Biophys Res Commun 2008 Oct 20;375(3):399-404. Epub 2008 Aug 20.

Department of Radiation Oncology, University Hospital Zurich, CH-8091 Zurich, Switzerland.

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http://dx.doi.org/10.1016/j.bbrc.2008.08.035DOI Listing
October 2008

Targeting the phosphoinositide 3-kinase isoform p110delta impairs growth and survival in neuroblastoma cells.

Clin Cancer Res 2008 Feb;14(4):1172-81

Division of Clinical Chemistry and Biochemistry, University Children's Hospital Zurich, Zurich, Switzerland.

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http://dx.doi.org/10.1158/1078-0432.CCR-07-0737DOI Listing
February 2008

Salbutamol exhibits androgenic activity in vitro.

Br J Sports Med 2007 Dec 17;41(12):874-8; discussion 878. Epub 2007 May 17.

Institute of Pharmacology and Toxicology, University of Zurich, Switzerland.

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http://dx.doi.org/10.1136/bjsm.2007.035162DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2658979PMC
December 2007

The histone deacetylase inhibitors suberoylanilide hydroxamic (Vorinostat) and valproic acid induce irreversible and MDR1-independent resistance in human colon cancer cells.

Int J Oncol 2007 Sep;31(3):633-41

Department of Gynecology, University Hospital of Zurich, Zurich, Switzerland.

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September 2007