Publications by authors named "Andre Fischer"

100Publications

Conformational Changes of Thyroid Receptors in Response to Antagonists.

J Chem Inf Model 2021 Jan 15. Epub 2021 Jan 15.

Computational Pharmacy, Department of Pharmaceutical Sciences, University of Basel, Klingelbergstrasse 61, Basel 4056, Switzerland.

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January 2021

Functional Divergence of Mammalian TFAP2a and TFAP2b Transcription Factors for Bidirectional Sleep Control.

Genetics 2020 Nov 7;216(3):735-752. Epub 2020 Aug 7.

Max Planck Research Group "Sleep and Waking", Max Planck Institute for Biophysical Chemistry, Göttingen 37077, Germany

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November 2020

Developmental GABA polarity switch and neuronal plasticity in Bioengineered Neuronal Organoids.

Nat Commun 2020 07 29;11(1):3791. Epub 2020 Jul 29.

Institute of Pharmacology and Toxicology, University Medical Center, Georg-August-University, Göttingen, Germany.

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July 2020

Potential Inhibitors for Novel Coronavirus Protease Identified by Virtual Screening of 606 Million Compounds.

Int J Mol Sci 2020 May 21;21(10). Epub 2020 May 21.

Computational Pharmacy, Department of Pharmaceutical Sciences, University of Basel, 4056 Basel, Switzerland.

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May 2020

Allosteric Binding Sites On Nuclear Receptors: Focus On Drug Efficacy and Selectivity.

Int J Mol Sci 2020 Jan 14;21(2). Epub 2020 Jan 14.

Computational Pharmacy, Department of Pharmaceutical Sciences, University of Basel, Klingelbergstrasse 50, CH-4056 Basel, Switzerland.

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January 2020

Spontaneous Ligand Access Events to Membrane-Bound Cytochrome P450 2D6 Sampled at Atomic Resolution.

Sci Rep 2019 11 11;9(1):16411. Epub 2019 Nov 11.

University of Basel, Department of Pharmaceutical Sciences, Basel, 4056, Switzerland.

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November 2019

TIP60/KAT5 is required for neuronal viability in hippocampal CA1.

Sci Rep 2019 11 7;9(1):16173. Epub 2019 Nov 7.

Genes and Behavior Department, Max Planck Institute for Biophysical Chemistry, 37077, Göttingen, Germany.

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November 2019

A combined miRNA-piRNA signature to detect Alzheimer's disease.

Transl Psychiatry 2019 10 7;9(1):250. Epub 2019 Oct 7.

Department for Epigenetics and Systems Medicine in Neurodegenerative Diseases, German Center for Neurodegenerative Diseases (DZNE) Goettingen, 37075, Göttingen, Germany.

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October 2019

The Role of Dynamic Histone Modifications in Learning Behavior.

Authors:
Andre Fischer

Curr Top Behav Neurosci 2019 ;42:127-157

Department for Psychiatry and Psychotherapy, University Medical Center Göttingen, Göttingen, Germany.

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January 2020

Ligand Pathways in Nuclear Receptors.

J Chem Inf Model 2019 07 11;59(7):3100-3109. Epub 2019 Jul 11.

Molecular Modeling, Pharmacenter of the University of Basel , University of Basel , Klingelbergstrasse 50 , 4056 Basel , Switzerland.

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July 2019

Childhood Trauma in Schizophrenia: Current Findings and Research Perspectives.

Front Neurosci 2019 21;13:274. Epub 2019 Mar 21.

Department of Psychiatry and Psychotherapy, University Hospital, Ludwig Maximilian University of Munich, Munich, Germany.

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March 2019

FOXG1 Regulates PRKAR2B Transcriptionally and Posttranscriptionally via miR200 in the Adult Hippocampus.

Mol Neurobiol 2019 Jul 11;56(7):5188-5201. Epub 2018 Dec 11.

Institute of Anatomy and Cell Biology, Department of Molecular Embryology, Faculty of Medicine, Albert-Ludwigs-University Freiburg, 79104, Freiburg, Germany.

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July 2019

Chromatin Remodeling BAF155 Subunit Regulates the Genesis of Basal Progenitors in Developing Cortex.

iScience 2018 Jun 23;4:109-126. Epub 2018 May 23.

Institute of Neuroanatomy, University Medical Center, Georg-August-University, 37075 Goettingen, Germany; DFG, Center for Molecular Physiology of the Brain (CMPB), 37075 Goettingen, Germany. Electronic address:

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June 2018

Molecular Dynamics Simulations Reveal Structural Differences among Allelic Variants of Membrane-Anchored Cytochrome P450 2D6.

J Chem Inf Model 2018 09 4;58(9):1962-1975. Epub 2018 Sep 4.

Molecular Modeling, Department of Pharmaceutical Sciences , University of Basel , Klingelbergstrasse 50 , 4056 Basel , Switzerland.

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September 2018

Alpha-synuclein deregulates the expression of COL4A2 and impairs ER-Golgi function.

Neurobiol Dis 2018 11 6;119:121-135. Epub 2018 Aug 6.

Department of Experimental Neurodegeneration, Center for Nanoscale Microscopy and Molecular Physiology of the Brain, Center for Biostructural Imaging of Neurodegeneration, University Medical Center Göttingen, Göttingen 37073, Germany; CEDOC - Chronic Diseases Research Center, Faculdade de Ciencias Medicas, Universidade Nova de Lisboa, Lisboa, Portugal; Max Planck Institute for Experimental Medicine, Göttingen 37075, Germany; Institute of Neuroscience, The Medical School, Newcastle University, Framlington Place, Newcastle NE2 4HH, UK. Electronic address:

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November 2018

miR-182-5p and miR-183-5p Act as GDNF Mimics in Dopaminergic Midbrain Neurons.

Mol Ther Nucleic Acids 2018 Jun 2;11:9-22. Epub 2018 Feb 2.

Department of Neurology, University Medical Center Göttingen, Robert-Koch-Str. 40, 37075 Göttingen, Lower-Saxony, Germany; DFG Cluster of Excellence Nanoscale Microscopy and Molecular Physiology of the Brain (CNMPB), University Medical Center Göttingen, Robert-Koch-Str. 40, 37075 Göttingen, Lower-Saxony, Germany. Electronic address:

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June 2018

Epigenetic Regulation by BAF Complexes Limits Neural Stem Cell Proliferation by Suppressing Wnt Signaling in Late Embryonic Development.

Stem Cell Reports 2018 06 17;10(6):1734-1750. Epub 2018 May 17.

Institute of Neuroanatomy, University Medical Center, Georg-August- University, 37075 Goettingen, Germany; DFG Center for Nanoscale Microscopy & Molecular Physiology of the Brain (CNMPB), 37075 Goettingen, Germany. Electronic address:

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June 2018

RNA-Dependent Intergenerational Inheritance of Enhanced Synaptic Plasticity after Environmental Enrichment.

Cell Rep 2018 Apr;23(2):546-554

Department for Epigenetics and Systems Medicine in Neurodegenerative Diseases, German Center for Neurodegenerative Diseases (DZNE) Göttingen, von Siebold Strasse 3A, 37075 Göttingen, Germany; Department of Psychiatry and Psychotherapy, University Medical Center Göttingen, Von Siebold Strasse 5, 37075 Göttingen, Germany. Electronic address:

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April 2018

Epigenetische Prozesse als Drug Targets.

Authors:
André Fischer

Drug Res (Stuttg) 2017 Nov 25;67(S 01):S9. Epub 2017 Oct 25.

Deutsches Zentrum für Neurodegenerative Erkrankungen, Göttingen, Universitätsmedizin Göttingen.

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November 2017

Absence of Nucleotide-Oligomerization-Domain-2 Is Associated with Less Distinct Disease in Infected Secondary Abiotic IL-10 Deficient Mice.

Front Cell Infect Microbiol 2017 13;7:322. Epub 2017 Jul 13.

Department of Microbiology and Hygiene, Charité-University Medicine BerlinBerlin, Germany.

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March 2018

KMT2A and KMT2B Mediate Memory Function by Affecting Distinct Genomic Regions.

Cell Rep 2017 07;20(3):538-548

Department for Psychiatry and Psychotherapy, University Medical Center Goettingen, Goettingen 37075, Germany; German Center for Neurodegenerative Diseases, Epigenetics, and Systems Medicine in Neurodegenerative Diseases, University Medical Center Goettingen, Goettingen 37075, Germany. Electronic address:

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July 2017

Small Intestinal Pro-Inflammatory Immune Responses Following Infection of Secondary Abiotic IL-10 Mice Lacking Nucleotide-Oligomerization-Domain-2.

Eur J Microbiol Immunol (Bp) 2017 Jun 27;7(2):138-145. Epub 2017 Jun 27.

Department of Microbiology and Hygiene, Charité - University Medicine Berlin, Berlin, Germany.

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June 2017

Immune responses upon infection of secondary abiotic mice lacking nucleotide-oligomerization-domain-2.

Gut Pathog 2017 6;9:33. Epub 2017 Jun 6.

Department of Microbiology and Hygiene, Charité-University Medicine Berlin, CC5, Campus Benjamin Franklin, FEM, Garystr. 5, 14195 Berlin, Germany.

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June 2017

Microbiota Composition and Immune Responses During Infection in Conventionally Colonized IL-10 Mice Lacking Nucleotide Oligomerization Domain 2.

Eur J Microbiol Immunol (Bp) 2017 Mar 20;7(1):1-14. Epub 2016 Dec 20.

Department of Microbiology and Hygiene, Charité - University Medicine Berlin , Berlin, Germany.

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March 2017

Sodium butyrate rescues dopaminergic cells from alpha-synuclein-induced transcriptional deregulation and DNA damage.

Hum Mol Genet 2017 06;26(12):2231-2246

Department of Experimental Neurodegeneration, Center for Nanoscale Microscopy and Molecular Physiology of the Brain, Center for Biostructural Imaging of Neurodegeneration, University Medical Center Göttingen, 37073, Göttingen, Germany.

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June 2017

Fatal Familial Insomnia: Clinical Aspects and Molecular Alterations.

Curr Neurol Neurosci Rep 2017 04;17(4):30

Institute of Neuropathology, Bellvitge University Hospital-IDIBELL, L'Hospitalet de Llobregat, c/Feixa Llarga sn, 08907, Barcelona, Spain.

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April 2017

Validation of α-Synuclein as a CSF Biomarker for Sporadic Creutzfeldt-Jakob Disease.

Mol Neurobiol 2018 03 21;55(3):2249-2257. Epub 2017 Mar 21.

Clinical Dementia Center, Department of Neurology, University Medical Center Göttingen, Robert Koch Stasse 40, 37075, Göttingen, Germany.

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March 2018

infection of conventionally colonized mice lacking nucleotide-oligomerization-domain-2.

Gut Pathog 2017 21;9. Epub 2017 Jan 21.

Department of Microbiology and Hygiene, Charité-University Medicine Berlin, CC5, Campus Benjamin Franklin, FEM, Garystr. 5, 14195 Berlin, Germany.

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January 2017

Colonic Expression of Genes Encoding Inflammatory Mediators and Gelatinases During Campylobacter Jejuni Infection of Conventional Infant Mice.

Eur J Microbiol Immunol (Bp) 2016 Jun 25;6(2):137-46. Epub 2016 Apr 25.

Department of Microbiology and Hygiene, Charité - University Medicine Berlin , Berlin, Germany.

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June 2016

The Role of IL-23, IL-22, and IL-18 in Campylobacter Jejuni Infection of Conventional Infant Mice.

Eur J Microbiol Immunol (Bp) 2016 Jun 25;6(2):124-36. Epub 2016 Apr 25.

Department of Microbiology and Hygiene, Charité - University Medicine Berlin , Berlin, Germany.

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June 2016

The IL-23/IL-22/IL-18 axis in murine Campylobacter jejuni infection.

Gut Pathog 2016 6;8:21. Epub 2016 Jul 6.

Department of Microbiology and Hygiene, Charité-University Medicine Berlin, CC5, Campus Benjamin Franklin, FEM, Garystr. 5, 14195 Berlin, Germany.

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July 2016

Interleukin-18 Mediates Immune Responses to Campylobacter jejuni Infection in Gnotobiotic Mice.

PLoS One 2016 20;11(6):e0158020. Epub 2016 Jun 20.

Department of Microbiology and Hygiene, Charité - University Medicine Berlin, Berlin, Germany.

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July 2017

Depletion of Cultivatable Gut Microbiota by Broad-Spectrum Antibiotic Pretreatment Worsens Outcome After Murine Stroke.

Stroke 2016 05 7;47(5):1354-63. Epub 2016 Apr 7.

From the Department of Experimental Neurology (K.W., O.E., P.K., N.O., A.M., U.D.), NeuroCure Clinical Research (K.W., C.C., A.M., U.D.), Center for Stroke Research Berlin (K.W., O.E., P.K., A.M., U.D.), Department of Microbiology and Hygiene (M.M.H., A.F., S.B.), Institute for Medical Immunology (C.D., C.M.), and Department of Neurology (A.M., U.D.), Charité - Universitätsmedizin Berlin, Germany; Institute of Veterinary Pathology, Faculty of Veterinary Medicine, Freie Universität Berlin, Germany (O.K., A.D.G.); German Rheumatism Research Center (DRFZ), Berlin, Germany (C.C.); and German Center for Neurodegeneration Research (DZNE), partner site Berlin, Germany (U.D.).

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May 2016

Toll-Like Receptor-4 Dependent Small Intestinal Immune Responses Following Murine Arcobacter Butzleri Infection.

Eur J Microbiol Immunol (Bp) 2015 Dec 17;5(4):333-42. Epub 2015 Nov 17.

Institute of Food Hygiene, Freie Universität Berlin , Berlin, Germany.

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December 2015

Toll-Like Receptor-4 is Essential for Arcobacter Butzleri-Induced Colonic and Systemic Immune Responses in Gnotobiotic IL-10(-/-) Mice.

Eur J Microbiol Immunol (Bp) 2015 Dec 18;5(4):321-32. Epub 2015 Nov 18.

Department of Microbiology and Hygiene, Charité - University Medicine Berlin , Berlin, Germany.

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December 2015

The Role of Gelatinases in Campylobacter Jejuni Infection of Gnotobiotic Mice.

Eur J Microbiol Immunol (Bp) 2015 Dec 21;5(4):256-67. Epub 2015 Oct 21.

Department of Microbiology and Hygiene, Charité - University Medicine Berlin , Berlin, Germany.

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December 2015

Environmental enrichment as a method to improve cognitive function. What can we learn from animal models?

Authors:
Andre Fischer

Neuroimage 2016 05 30;131:42-7. Epub 2015 Nov 30.

Research Group for Epigenetics in Neurodegenerative Diseases, German Center for Neurodegenerative Diseases (DZNE) Göttingen, Grisebachstr. 5, 37077 Göttingen, Germany; Department of Psychiatry and Psychotherapy, University Medical Center Göttingen, Grisebachstr. 5, 37077 Göttingen, Germany. Electronic address:

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May 2016

Loss of BAF (mSWI/SNF) Complexes Causes Global Transcriptional and Chromatin State Changes in Forebrain Development.

Cell Rep 2015 Dec 19;13(9):1842-54. Epub 2015 Nov 19.

Institute of Neuroanatomy, University Medical Center, Georg-August-University Goettingen, 37075 Goettingen, Germany; DFG Center for Nanoscale Microscopy & Molecular Physiology of the Brain (CNMPB), 37075 Goettingen, Germany. Electronic address:

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December 2015

Dynamic Contrast-Enhanced Magnetic Resonance Imaging for Quantitative Lung Perfusion Imaging Using the Dual-Bolus Approach: Comparison of 3 Contrast Agents and Recommendation of Feasible Doses.

Invest Radiol 2016 Mar;51(3):186-93

From the *Department of Diagnostic and Interventional Radiology, University Hospital Würzburg, Würzburg; †Department of Radiation Oncology, Klinikum rechts der Isar, Technische Universität München, Munich; and ‡Department of Diagnostic and Interventional Radiology Universitätsmedizin Göttingen, Göttingen, Germany.

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March 2016

Anti-Inflammatory Properties of NAP in Acute Toxoplasma Gondii-Induced Ileitis in Mice.

Eur J Microbiol Immunol (Bp) 2015 Sep 18;5(3):210-20. Epub 2015 Sep 18.

Department of Microbiology and Hygiene, Charité - University Medicine Berlin , Berlin, Germany.

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September 2015

Matrix Metalloproteinase-2 Mediates Intestinal Immunopathogenesis in Campylobacter Jejuni-Infected Infant Mice.

Eur J Microbiol Immunol (Bp) 2015 Sep 18;5(3):188-98. Epub 2015 Sep 18.

Department of Microbiology and Hygiene, Charité - University Medicine Berlin , Berlin, Germany.

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September 2015

Genetic deletion of the Histone Deacetylase 6 exacerbates selected behavioral deficits in the R6/1 mouse model for Huntington's disease.

Brain Behav 2015 Sep 24;5(9):e00361. Epub 2015 Jun 24.

Institut de Neurosciences Cognitives et Intégratives d'Aquitaine, CNRS UMR 5287 Avenue des Facultés, 33405, Talence Cedex, France ; University of Bordeaux 146, rue Léo-Saignat, 33077, Bordeaux, France.

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September 2015

Remodeling the susceptibility to stress-induced depression.

Nat Med 2015 Oct;21(10):1125-6

Research Group for Epigenetics in Neurodegenerative Diseases, German Center for Neurodegenerative Diseases (DZNE) Göttingen, Göttingen, Germany.

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October 2015

New friends for Ago2 in neuronal plasticity.

EMBO J 2015 Sep 28;34(17):2213-4. Epub 2015 Jul 28.

Research Group for Epigenetics in Neurodegenerative Diseases, German Center for Neurodegenerative Diseases (DZNE), Göttingen, Germany Department of Psychiatry and Psychotherapy, University Medical Center, Göttingen, Germany.

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September 2015

H4K12ac is regulated by estrogen receptor-alpha and is associated with BRD4 function and inducible transcription.

Oncotarget 2015 Mar;6(9):7305-17

Department of General, Visceral and Pediatric Surgery, University Medical Center Göttingen, Göttingen, Germany.

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March 2015

Oasis: online analysis of small RNA deep sequencing data.

Bioinformatics 2015 Jul 19;31(13):2205-7. Epub 2015 Feb 19.

Laboratory of Computational Systems Biology and Laboratory of Epigenetic Mechanisms in Dementia, German Center for Neurodegenerative Diseases, 37077 Goettingen, Germany.

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July 2015

Characterization of the MeCP2R168X knockin mouse model for Rett syndrome.

PLoS One 2014 26;9(12):e115444. Epub 2014 Dec 26.

University Medical Center Göttingen, Department of Child and Adolescent Health - Division of Neuropediatrics, Göttingen, Germany.

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August 2015

De-regulation of gene expression and alternative splicing affects distinct cellular pathways in the aging hippocampus.

Front Cell Neurosci 2014 13;8:373. Epub 2014 Nov 13.

Department of Psychiatry and Psychotherapy, University Medical Center Göttingen Göttingen, Germany ; Research Group for Epigenetics in Neurodegenerative Diseases, German Center for Neurodegenerative Diseases (DZNE) Göttingen Göttingen, Germany.

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November 2014

K-Lysine acetyltransferase 2a regulates a hippocampal gene expression network linked to memory formation.

EMBO J 2014 Sep 14;33(17):1912-27. Epub 2014 Jul 14.

Department of Psychiatry and Psychotherapy, University Medical Center, Göttingen, Germany Research group for Epigenetics in Neurodegenerative Diseases, German Center for Neurodegenerative Diseases (DZNE), Göttingen, Germany

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September 2014

Histone-acetylation: a link between Alzheimer's disease and post-traumatic stress disorder?

Front Neurosci 2014 24;8:160. Epub 2014 Jun 24.

Department of Psychiatry and Psychotherapy, University Medical Center Göttingen Göttingen, Germany ; Research Group for Epigenetics in Neurodegenerative Diseases, German Center for Neurodegenerative Diseases (DZNE) Göttingen Germany.

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July 2014

MicroRNA-125b induces tau hyperphosphorylation and cognitive deficits in Alzheimer's disease.

EMBO J 2014 Aug 7;33(15):1667-80. Epub 2014 Jul 7.

German Center for Neurodegenerative Diseases, Munich, Germany Adolf Butenandt Institute, Biochemistry, Ludwig-Maximilians-University Munich, Munich, Germany Munich Cluster of Systems Neurology (SyNergy), Munich, Germany

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August 2014

The impact of Toll-like-receptor-9 on intestinal microbiota composition and extra-intestinal sequelae in experimental Toxoplasma gondii induced ileitis.

Gut Pathog 2014 6;6:19. Epub 2014 Jun 6.

Department of Microbiology and Hygiene, Charité - University Medicine Berlin, Centrum 5, Campus Benjamin Franklin, Hindenburgdamm 27, D-12203 Berlin, Germany.

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June 2014

Small intestinal permeability in older adults.

Physiol Rep 2014 22;2(4):e00281. Epub 2014 Apr 22.

Department of Gastroenterology and Hepatology, Section of Nutritional Medicine, Charité - Universitätsmedizin Berlin, Berlin, Germany.

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April 2014

Epigenetic memory: the Lamarckian brain.

Authors:
Andre Fischer

EMBO J 2014 May 9;33(9):945-67. Epub 2014 Apr 9.

Department of Psychiatry and Psychotherapy, University Medical Center Göttingen, Göttingen, Germany.

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May 2014

Targeting histone-modifications in Alzheimer's disease. What is the evidence that this is a promising therapeutic avenue?

Authors:
Andre Fischer

Neuropharmacology 2014 May 31;80:95-102. Epub 2014 Jan 31.

Department of Psychiatry and Psychotherapy, University Medical Center Göttingen, Grisebachstr. 5, 37077 Göttingen, Germany; Research Group for Epigenetic Mechansims of Neurodegenerative Diseases, German Center for Neurodegenerative Diseases (DZNE) Göttingen, Grisebachstr. 5, 37077 Göttingen, Germany. Electronic address:

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May 2014