Anders Rane

Anders Rane

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Anders Rane

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Encouraging prospects for paediatric drug development in Europe.

Authors:
Anders Rane

Acta Paediatr 2020 Mar 26;109(3):438-439. Epub 2019 Nov 26.

Clinical Pharmacology, Karolinska Institutet, Karolinska University Hospital (Huddinge), Stockholm, Sweden.

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http://dx.doi.org/10.1111/apa.15075DOI Listing
March 2020

Improved infrastructure and support needed for paediatric clinical trials in Sweden.

Acta Paediatr 2020 Mar 14. Epub 2020 Mar 14.

Department for Clinical Sciences, Paediatrics, Umeå University, Umeå, Sweden.

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http://dx.doi.org/10.1111/apa.15254DOI Listing
March 2020

Individual variations in fentanyl pharmacokinetics and pharmacodynamics in preterm infants.

Acta Paediatr 2019 08 19;108(8):1441-1446. Epub 2019 Mar 19.

Department of Clinical Sciences, Pediatrics, Lund, Lund University, Lund, Sweden.

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https://onlinelibrary.wiley.com/doi/abs/10.1111/apa.14744
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http://dx.doi.org/10.1111/apa.14744DOI Listing
August 2019

Tardy development of safe medicines for children: a Nordic network offers new platform to reduce this inequity.

Acta Paediatr 2019 06 7;108(6):992-993. Epub 2019 Apr 7.

Department of Children and Adolescents, Helsinki University Hospital, Helsinki, Finland.

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http://dx.doi.org/10.1111/apa.14775DOI Listing
June 2019

Combined effect of telmisartan and fluvastatin on arachidonic acid metabolism in human liver microsomes.

Xenobiotica 2018 Sep 13;48(9):898-903. Epub 2017 Oct 13.

a Division of Clinical Pharmacology, Hokkaido Pharmaceutical University School of Pharmacy , Sapporo , Japan and.

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https://www.tandfonline.com/doi/full/10.1080/00498254.2017.1
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http://dx.doi.org/10.1080/00498254.2017.1384079DOI Listing
September 2018

Pregnancy-Induced Perturbation of Urinary Androgenic Steroid Disposition.

J Endocr Soc 2018 Jul 23;2(7):597-608. Epub 2018 May 23.

Division of Clinical Pharmacology, Department of Laboratory Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.

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http://dx.doi.org/10.1210/js.2018-00064DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6007248PMC
July 2018

The Inhibitory Effect of Telmisartan on the Metabolism of Arachidonic Acid by CYP2C9 and CYP2C8: An in Vitro Study.

Biol Pharm Bull 2017 ;40(9):1409-1415

Division of Clinical Pharmacology, Hokkaido Pharmaceutical University School of Pharmacy.

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http://dx.doi.org/10.1248/bpb.b17-00174DOI Listing
May 2018

Sensitivity of doping biomarkers after administration of a single dose testosterone gel.

Drug Test Anal 2018 May 28;10(5):839-848. Epub 2017 Dec 28.

Department of Laboratory Medicine, Division of Clinical Pharmacology, Karolinska Institutet at Huddinge, Huddinge, Sweden.

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http://dx.doi.org/10.1002/dta.2341DOI Listing
May 2018

Pregnancy greatly affects the steroidal module of the Athlete Biological Passport.

Drug Test Anal 2018 Jan 18. Epub 2018 Jan 18.

Department of Laboratory Medicine, Division of Clinical Pharmacology, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.

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http://dx.doi.org/10.1002/dta.2361DOI Listing
January 2018

Vitamin D receptor rs2228570 polymorphism is associated with LH levels in men exposed to anabolic androgenic steroids.

BMC Res Notes 2018 Jan 19;11(1):51. Epub 2018 Jan 19.

Division of Clinical Pharmacology, Department of Laboratory Medicine, Karolinska Institute, Karolinska University Hospital, Huddinge, 141 86, Stockholm, Sweden.

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http://dx.doi.org/10.1186/s13104-018-3173-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5775552PMC
January 2018

Angiotensin II Receptor Blockers Inhibit the Generation of Epoxyeicosatrienoic Acid from Arachidonic Acid in Recombinant CYP2C9, CYP2J2 and Human Liver Microsomes.

Basic Clin Pharmacol Toxicol 2017 Oct 10;121(4):239-245. Epub 2017 May 10.

Division of Clinical Pharmacology, Hokkaido Pharmaceutical University School of Pharmacy, Sapporo, Hokkaido, Japan.

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http://dx.doi.org/10.1111/bcpt.12789DOI Listing
October 2017

Reply to 'Multiple and Opposite Effects of Angiotensin II Receptor Blockers on the Bioavailability of Epoxyeicosatrienoic Acids'.

Basic Clin Pharmacol Toxicol 2017 10 22;121(4):215-216. Epub 2017 Jun 22.

Division of Clinical Pharmacology, Hokkaido Pharmaceutical University School of Pharmacy, Sapporo, Hokkaido, Japan.

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http://dx.doi.org/10.1111/bcpt.12811DOI Listing
October 2017

Discordant genotyping results using DNA isolated from anti-doping control urine samples.

Drug Test Anal 2017 Jul 4;9(7):994-1000. Epub 2016 Nov 4.

Department Laboratory Medicine, Division of Clinical Pharmacology, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1002/dta.2103DOI Listing
July 2017

[Ten years of EU legislation on medicinal products for pediatric use].

Authors:
Anders Rane

Lakartidningen 2017 04 26;114. Epub 2017 Apr 26.

Karolinska Institutet - Clin Pharmacology/Laboratory Medicine Stockholm, Sweden Karolinska Institutet - Clin Pharmacology/Laboratory Medicine Stockholm, Sweden.

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April 2017

Statin-induced myopathy in a usual care setting-a prospective observational study of gender differences.

Eur J Clin Pharmacol 2016 Oct 2;72(10):1171-1176. Epub 2016 Aug 2.

Division of Clinical Pharmacology, Department of Laboratory Medicine, Karolinska University Hospital Huddinge, 141 86, Stockholm, SE, Sweden.

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http://dx.doi.org/10.1007/s00228-016-2105-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5021730PMC
October 2016

Dose-dependent testosterone sensitivity of the steroidal passport and GC-C-IRMS analysis in relation to the UGT2B17 deletion polymorphism.

Drug Test Anal 2015 Nov-Dec;7(11-12):1063-70. Epub 2015 Jul 22.

Department of Laboratory Medicine, Division of Clinical Pharmacology, Karolinska Institutet, SE-141 86, Stockholm, Sweden.

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http://dx.doi.org/10.1002/dta.1841DOI Listing
September 2016

Effects of Angiotensin II Receptor Blockers on Metabolism of Arachidonic Acid via CYP2C8.

Biol Pharm Bull 2015 ;38(12):1975-9

Division of Clinical Pharmacology, Hokkaido Pharmaceutical University School of Pharmacy.

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http://dx.doi.org/10.1248/bpb.b15-00577DOI Listing
September 2016

Genetic Predisposition to Poor Opioid Response in Preterm Infants: Impact of KCNJ6 and COMT Polymorphisms on Pain Relief After Endotracheal Intubation.

Ther Drug Monit 2016 08;38(4):525-33

*Department Clinical Chemistry, Erasmus University Medical Center, Rotterdam, the Netherlands; †Louvain Drug Research Institute, Université catholique de Louvain, Brussels, Belgium; ‡Unit of Pediatrics, Department of Clinical Sciences, Lund, Lund University and Skåne University Hospital, Lund, Sweden; §Department of Laboratory Medicine, Division of Clinical Pharmacology, Karolinska Institutet at Karolinska University Hospital, Huddinge, Stockholm, Sweden; and ¶Children's Hospital, University of Helsinki and Helsinki University Hospital, Finland.

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http://dx.doi.org/10.1097/FTD.0000000000000301DOI Listing
August 2016

Simultaneous Determination Method of Epoxyeicosatrienoic Acids and Dihydroxyeicosatrienoic Acids by LC-MS/MS System.

Biol Pharm Bull 2015 ;38(10):1673-9

Division of Clinical Pharmacology, Hokkaido Pharmaceutical University School of Pharmacy.

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http://dx.doi.org/10.1248/bpb.b15-00480DOI Listing
July 2016

The Role of CYP2C8 and CYP2C9 Genotypes in Losartan-Dependent Inhibition of Paclitaxel Metabolism in Human Liver Microsomes.

Basic Clin Pharmacol Toxicol 2016 Jun 28;118(6):408-14. Epub 2015 Dec 28.

Division of Clinical Pharmacology, Hokkaido Pharmaceutical University School of Pharmacy, Sapporo, Japan.

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http://dx.doi.org/10.1111/bcpt.12520DOI Listing
June 2016

Atypical excretion profile and GC/C/IRMS findings may last for nine months after a single dose of nandrolone decanoate.

Steroids 2016 Apr 4;108:105-11. Epub 2016 Feb 4.

Department of Laboratory Medicine, Division of Clinical Pharmacology, Karolinska Institutet, SE-14186 Stockholm, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.steroids.2016.02.004DOI Listing
April 2016

Low Vitamin D Levels and Genetic Polymorphism in the Vitamin D Receptor are Associated with Increased Risk of Statin-Induced Myopathy.

Basic Clin Pharmacol Toxicol 2016 Mar 1;118(3):214-8. Epub 2015 Oct 1.

Division of Clinical Microbiology, Department of Laboratory Medicine, Karolinska Institutet, Karolinska University Hospital, Huddinge, Stockholm, Sweden.

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http://dx.doi.org/10.1111/bcpt.12482DOI Listing
March 2016

Recruitment to doping and help-seeking behavior of eight female AAS users.

Subst Abuse Treat Prev Policy 2016 Mar 5;11:11. Epub 2016 Mar 5.

Department of Laboratory Medicine, Karolinska Institutet, Karolinska University Hospital, SE-141 86, Stockholm, Sweden.

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http://dx.doi.org/10.1186/s13011-016-0056-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4779574PMC
March 2016

miRNA-27b levels are associated with CYP3A activity in vitro and in vivo.

Pharmacol Res Perspect 2015 12 27;3(6):e00192. Epub 2015 Oct 27.

Division of Clinical Microbiology Department of Laboratory Medicine Karolinska Institutet Karolinska University Hospital, Huddinge SE-141 86 Stockholm Sweden; Palliative Home Care and Hospice Ward ASIH Stockholm Södra Långbro Park Bergtallsvägen 12SE-125 59 Älvsjö Sweden.

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http://dx.doi.org/10.1002/prp2.192DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4777245PMC
December 2015

Expression of CYP3A4 and CYP3A7 in Human Foetal Tissues and its Correlation with Nuclear Receptors.

Basic Clin Pharmacol Toxicol 2015 Oct 9;117(4):261-6. Epub 2015 Mar 9.

Division of Clinical Pharmacology, Karolinska Institute, Karolinska University Hospital Huddinge, Stockholm, Sweden.

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http://dx.doi.org/10.1111/bcpt.12392DOI Listing
October 2015

[Healing agents from the roof of the world].

Lakartidningen 2015 Sep 22;112. Epub 2015 Sep 22.

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September 2015

Statin-induced Myopathy and Ubiquinone Levels in Serum - Results from a Prospective, Observational Study.

Basic Clin Pharmacol Toxicol 2015 Aug 28;117(2):133-6. Epub 2015 Jan 28.

Division of Clinical Microbiology, Department of Laboratory Medicine, Karolinska Institute, Karolinska University Hospital, Huddinge, Stockholm, Sweden.

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http://dx.doi.org/10.1111/bcpt.12375DOI Listing
August 2015

Effect of UGT2B7 -900G>A (-842G>A; rs7438135) on morphine glucuronidation in preterm newborns: results from a pilot cohort.

Pharmacogenomics 2014 ;15(12):1589-97

Department Clinical Chemistry, Erasmus MC - University Medical Center Rotterdam, The Netherlands.

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http://dx.doi.org/10.2217/pgs.14.115DOI Listing
June 2015

Drug-drug Interaction between Losartan and Paclitaxel in Human Liver Microsomes with Different CYP2C8 Genotypes.

Basic Clin Pharmacol Toxicol 2015 Jun 23;116(6):493-8. Epub 2014 Dec 23.

Division of Clinical Pharmacology, Hokkaido Pharmaceutical University School of Pharmacy, Otaru, Japan.

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http://dx.doi.org/10.1111/bcpt.12355DOI Listing
June 2015

Losartan competitively inhibits CYP2C8-dependent paclitaxel metabolism in vitro.

Biol Pharm Bull 2014 ;37(9):1550-4

Division of Clinical Pharmacology, Hokkaido Pharmaceutical University School of Pharmacy.

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http://dx.doi.org/10.1248/bpb.b14-00366DOI Listing
May 2015

Detection of morphine-3-sulfate and morphine-6-sulfate in human urine and plasma, and formation in liver cytosol.

Pharmacol Res Perspect 2014 Dec 1;2(6):e00071. Epub 2014 Sep 1.

Division of Clinical Pharmacology, Department of Laboratory Medicine Karolinska Institute, Stockholm, Sweden.

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http://dx.doi.org/10.1002/prp2.71DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4186450PMC
December 2014

Effects of different doses of testosterone on gonadotropins, 25-hydroxyvitamin D3, and blood lipids in healthy men.

Subst Abuse Rehabil 2014 10;5:121-7. Epub 2014 Dec 10.

Division of Clinical Pharmacology, Department of Laboratory Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.

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http://dx.doi.org/10.2147/SAR.S71285DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4266340PMC
December 2014

Prenatal expression of thioredoxin reductase 1 (TRXR1) and microsomal glutathione transferase 1 (MGST1) in humans.

FEBS Open Bio 2014 14;4:886-91. Epub 2014 Oct 14.

Division of Clinical Pharmacology, Department of Laboratory Medicine, Karolinska Institutet, Karolinska University Hospital, Huddinge, SE-141 86 Stockholm, Sweden.

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http://dx.doi.org/10.1016/j.fob.2014.10.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4215115PMC
November 2014

A supraphysiological dose of testosterone induces nitric oxide production and oxidative stress.

Eur J Prev Cardiol 2014 Aug 7;21(8):1049-54. Epub 2013 Mar 7.

Division of Clinical Pharmacology, Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden

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http://dx.doi.org/10.1177/2047487313481755DOI Listing
August 2014

PDE7B is involved in nandrolone decanoate hydrolysis in liver cytosol and its transcription is up-regulated by androgens in HepG2.

Front Pharmacol 2014 30;5:132. Epub 2014 May 30.

Division of Clinical Pharmaclogy, Department of Laboratory Medicine, Karolinska Institutet, Karolinska University Hospital Stockholm, Sweden.

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http://dx.doi.org/10.3389/fphar.2014.00132DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4038775PMC
June 2014

Seeking improved global child health: progress toward Millennium Development Goal 4.

Paediatr Drugs 2014 Apr;16(2):101-3

Child & Family Research Institute, BC Children's Hospital, 950 West 28th Ave, Vancouver, BC, V5Z 4H4, Canada,

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http://dx.doi.org/10.1007/s40272-014-0068-2DOI Listing
April 2014

CYP2C8 and CYP2C9 mRNA expression profile in the human fetus.

Front Genet 2014 25;5:58. Epub 2014 Mar 25.

Division of Clinical Pharmacology, Department of Laboratory Medicine, Karolinska Institutet Stockholm, Sweden.

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http://dx.doi.org/10.3389/fgene.2014.00058DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3971157PMC
April 2014

Expression of UGT2B7 is driven by two mutually exclusive promoters and alternative splicing in human tissues: changes from prenatal life to adulthood and in kidney cancer.

Pharmacogenet Genomics 2013 Dec;23(12):684-96

aPharmacogenomics Laboratory, Centre Hospitalier de l'Université Laval de Québec (CHU de Québec) Research Center and Faculty of Pharmacy bCHU de Québec Research Center and Faculty of Medicine, Laval University, Quebec, Canada cSkaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado, Aurora, Colorado dSchool of Medicine, Kidney Center, University of North Carolina, Chapel Hill, North Carolina, USA eDepartment of Laboratory Medicine, Division of Clinical Pharmacology, Karolinska Institute, Stockholm, Sweden.

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https://insights.ovid.com/crossref?an=01213011-201312000-000
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http://dx.doi.org/10.1097/FPC.0000000000000008DOI Listing
December 2013

[Steroids are a growing problem at gyms].

Lakartidningen 2013 Sep 25-Oct 8;110(39-40):1741-6

Karolinska institutet, Karolinska universitetssjukhuset Huddinge, Stockholm.

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December 2013

Atorvastatin treatment induces uptake and efflux transporters in human liver.

Drug Metab Dispos 2013 Sep 10;41(9):1610-5. Epub 2013 Jun 10.

Division of Clinical Pharmacology, Institutet, Karolinska University Hospital, Huddinge, Stockholm, Sweden.

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http://dx.doi.org/10.1124/dmd.113.051698DOI Listing
September 2013

SULT2A1 Gene Copy Number Variation is Associated with Urinary Excretion Rate of Steroid Sulfates.

Front Endocrinol (Lausanne) 2013 12;4:88. Epub 2013 Jul 12.

Laboratory Medicine, Division Clinical Pharmacology, Karolinska Institutet , Stockholm , Sweden.

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http://dx.doi.org/10.3389/fendo.2013.00088DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3709130PMC
July 2013

Implication of Human UGT2B7, 2B15, and 2B17 in 19-Norandrosterone Metabolism.

Front Endocrinol (Lausanne) 2013 26;4:75. Epub 2013 Jun 26.

Division of Clinical Pharmacology, Karolinska Institutet , Stockholm , Sweden.

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http://dx.doi.org/10.3389/fendo.2013.00075DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3693077PMC
June 2013

Non-steroidal anti-inflammatory drugs do not influence the urinary testosterone/epitestosterone glucuronide ratio.

Front Endocrinol (Lausanne) 2013 16;4:51. Epub 2013 May 16.

Division of Clinical Pharmacology, Department of Laboratory Medicine, Karolinska Institutet Stockholm, Sweden.

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http://dx.doi.org/10.3389/fendo.2013.00051DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3655282PMC
May 2013

Testosterone challenge and androgen receptor activity in relation to UGT2B17 genotypes.

Eur J Clin Invest 2013 Mar 7;43(3):248-55. Epub 2013 Jan 7.

Laboratory Medicine, Division Clinical Pharmacology, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1111/eci.12037DOI Listing
March 2013

Tissue distribution and relative gene expression of UDP-glucuronosyltransferases (2B7, 2B15, 2B17) in the human fetus.

Drug Metab Dispos 2013 Feb 4;41(2):291-5. Epub 2012 Dec 4.

Department Laboratory Medicine, Division of Clinical Pharmacology, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1124/dmd.112.049197DOI Listing
February 2013

Influence of simvastatin on the thromboxane and prostacyclin pathways, in vitro and in vivo.

J Cardiovasc Pharmacol 2013 Jan;61(1):1-7

Division of Clinical Pharmacology, Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1097/FJC.0b013e3182734508DOI Listing
January 2013

Institutional profile: Karolinska Institutet.

Pharmacogenomics 2012 Dec;13(16):1887-91

Karolinska Institutet, Department of Laboratory Medicine, Clinical Pharmacology, Karolinska University Hospital Huddinge, Stockholm, Sweden.

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http://dx.doi.org/10.2217/pgs.12.176DOI Listing
December 2012

DNA methylation dynamics in the hepatic CYP3A4 gene promoter.

Biochimie 2012 Nov 31;94(11):2338-44. Epub 2012 Jul 31.

Section of Pharmacogenetics, Department of Physiology and Pharmacology, Karolinska Institutet, SE-171 77 Stockholm, Sweden.

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http://dx.doi.org/10.1016/j.biochi.2012.07.013DOI Listing
November 2012

[Introduction of genetic analysis can provide us with safer doping tests. Large variation in androgen turnover creates problems in current tests].

Lakartidningen 2012 Jul 18-Aug 8;109(29-31):1347-9

Avdelningen för klinisk farmakologi, institutionen för laboratoriemedicin, Karolinska institutet, Karolinska universitetssjukhuset, Huddinge.

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September 2012

Androgens and doping tests: genetic variation and pit-falls.

Br J Clin Pharmacol 2012 Jul;74(1):3-15

Division of Clinical Pharmacology, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1111/j.1365-2125.2012.04294.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3394124PMC
July 2012

Pharmacokinetics of 250 μg anti-D IgG in the third trimester of pregnancy: an observational study.

Acta Obstet Gynecol Scand 2012 May 29;91(5):587-92. Epub 2012 Mar 29.

Department of Obstetrics and Gynecology, Karolinska University Hospital and Karolinska Institute, Stockholm, Sweden.

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http://dx.doi.org/10.1111/j.1600-0412.2012.01377.xDOI Listing
May 2012

Single dose testosterone increases total cholesterol levels and induces the expression of HMG CoA reductase.

Subst Abuse Treat Prev Policy 2012 Mar 20;7:12. Epub 2012 Mar 20.

Department of Laboratory Medicine, Division of Clinical Pharmacology, Karolinska Institutet, Karolinska University Hospital, SE-14186 Stockholm, Sweden.

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http://dx.doi.org/10.1186/1747-597X-7-12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3342114PMC
March 2012

Historical development of pediatric pharmacology.

Handb Exp Pharmacol 2011 ;205:v-vi

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February 2012

Beneficial vasoactive endothelial effects of fluvastatin: focus on prostacyclin and nitric oxide.

Heart Vessels 2011 Nov 7;26(6):628-36. Epub 2011 Jan 7.

Division of Clinical Pharmacology C1:68, Department of Laboratory Medicine, Karolinska University Hospital, 141 86, Stockholm, Sweden.

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http://dx.doi.org/10.1007/s00380-010-0097-xDOI Listing
November 2011

Androgen sulfation in healthy UDP-glucuronosyl transferase 2B17 enzyme-deficient men.

J Clin Endocrinol Metab 2011 Nov 17;96(11):3440-7. Epub 2011 Aug 17.

Department of Laboratory Medicine, Division of Clinical Pharmacology at Karolinska Institutet, Karolinska University Hospital, SE-141 86 Stockholm, Sweden.

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http://dx.doi.org/10.1210/jc.2011-0521DOI Listing
November 2011

Long term perturbation of endocrine parameters and cholesterol metabolism after discontinued abuse of anabolic androgenic steroids.

J Steroid Biochem Mol Biol 2011 Nov 22;127(3-5):295-300. Epub 2011 Aug 22.

Division of Clinical Pharmacology, Karolinska Institutet, Karolinska University Hospital, SE-141 86 Stockholm, Sweden.

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http://dx.doi.org/10.1016/j.jsbmb.2011.08.005DOI Listing
November 2011

Bioavailability of testosterone enanthate dependent on genetic variation in the phosphodiesterase 7B but not on the uridine 5'-diphospho-glucuronosyltransferase (UGT2B17) gene.

Pharmacogenet Genomics 2011 Jun;21(6):325-32

Laboratory Medicine, Division of Clinical Pharmacology, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.

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http://dx.doi.org/10.1097/FPC.0b013e328344c5c6DOI Listing
June 2011

Correlation between circulatory, local prostatic, and intra-prostatic androgen levels.

Prostate 2011 Jun 6;71(9):909-14. Epub 2010 Dec 6.

Department of Clinical Science, Intervention and Technology, Karolinska Institute, Stockholm, Sweden.

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http://dx.doi.org/10.1002/pros.21307DOI Listing
June 2011

Pharmacogenetics of anticoagulants.

Hum Genomics Proteomics 2010 Sep 13;2010:754919. Epub 2010 Sep 13.

Division of Clinical Pharmacology, Karolinska Institutet, 17177 Stockholm, Sweden.

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http://mr.crossref.org/iPage?doi=10.4061%2F2010%2F754919
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http://dx.doi.org/10.4061/2010/754919DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2958670PMC
September 2010

Dual use of anabolic-androgenic steroids and narcotics in Sweden.

Drug Alcohol Depend 2010 Jun 12;109(1-3):144-6. Epub 2010 Jan 12.

Department of Laboratory Medicine, Karolinska Institutet at Division of Clinical Pharmacology, Karolinska University Hospital, Sweden.

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http://dx.doi.org/10.1016/j.drugalcdep.2009.12.024DOI Listing
June 2010

Radical prostatectomy: influence on serum and urinary androgen levels.

Prostate 2010 Feb;70(2):200-5

Division of Urology, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.

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http://dx.doi.org/10.1002/pros.21053DOI Listing
February 2010

Non-steroidal anti-inflammatory drugs interact with testosterone glucuronidation.

Steroids 2009 Nov 28;74(12):971-7. Epub 2009 Jul 28.

Division of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Helsinki, FI-00014 Helsinki, Finland.

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http://dx.doi.org/10.1016/j.steroids.2009.07.004DOI Listing
November 2009

Roles of different CYP enzymes in the formation of specific fluvastatin metabolites by human liver microsomes.

Basic Clin Pharmacol Toxicol 2009 Nov 6;105(5):327-32. Epub 2009 Aug 6.

Division of Clinical Pharmacology, Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden.

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http://doi.wiley.com/10.1111/j.1742-7843.2009.00453.x
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http://dx.doi.org/10.1111/j.1742-7843.2009.00453.xDOI Listing
November 2009

Genetic variation in androgen disposition: implications in clinical medicine including testosterone abuse.

Expert Opin Drug Metab Toxicol 2009 Jul;5(7):731-44

Karolinska Institutet, Division of Clinical Pharmacology, Stockholm, Sweden.

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http://dx.doi.org/10.1517/17425250902976862DOI Listing
July 2009

SFINX-a drug-drug interaction database designed for clinical decision support systems.

Eur J Clin Pharmacol 2009 Jun 11;65(6):627-33. Epub 2009 Feb 11.

Division of Clinical Pharmacology, Department of Laboratory Medicine, Karolinska Institutet, Karolinska University Hospital, SE-14186 Stockholm, Sweden.

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http://dx.doi.org/10.1007/s00228-008-0612-5DOI Listing
June 2009

Influence of CYP2C9 genotype on warfarin dose requirements--a systematic review and meta-analysis.

Eur J Clin Pharmacol 2009 Apr 25;65(4):365-75. Epub 2008 Nov 25.

Division of Clinical Pharmacology, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1007/s00228-008-0584-5DOI Listing
April 2009

Substantial advantage of a combined Bayesian and genotyping approach in testosterone doping tests.

Steroids 2009 Mar 13;74(3):365-8. Epub 2008 Nov 13.

Department of Laboratory Medicine, Karolinska Institutet at Division of Clinical Pharmacology, Karolinska University Hospital, SE-141 86 Stockholm, Sweden.

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http://dx.doi.org/10.1016/j.steroids.2008.11.003DOI Listing
March 2009

The largest prospective warfarin-treated cohort supports genetic forecasting.

Blood 2009 Jan 23;113(4):784-92. Epub 2008 Jun 23.

Department of Medical Sciences, Clinical Pharmacology, Uppsala University Hospital, Uppsala, Sweden.

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http://dx.doi.org/10.1182/blood-2008-04-149070DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2630264PMC
January 2009

Expression of cytochrome P450 and MDR1 in patients with proctitis.

Ups J Med Sci 2007 ;112(3):303-12

Centre of Clinical Research, Uppsala University, Central Hospital, SE-721 89 Västerås, Sweden.

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http://dx.doi.org/10.3109/2000-1967-203DOI Listing
August 2008

Doping test results dependent on genotype of uridine diphospho-glucuronosyl transferase 2B17, the major enzyme for testosterone glucuronidation.

J Clin Endocrinol Metab 2008 Jul 11;93(7):2500-6. Epub 2008 Mar 11.

Clinical Pharmacology C1:68, Karolinska University Hospital, Huddinge, Stockholm, Sweden.

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https://academic.oup.com/jcem/article-lookup/doi/10.1210/jc.
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July 2008

Genetic aspects of epitestosterone formation and androgen disposition: influence of polymorphisms in CYP17 and UGT2B enzymes.

Pharmacogenet Genomics 2008 Jun;18(6):477-85

Department of Laboratory Medicine, Karolinska Institutet at Division of Clinical Pharmacology, Karolinska University Hospital, Stockholm, Sweden.

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http://dx.doi.org/10.1097/FPC.0b013e3282fad38aDOI Listing
June 2008

Use of doping agents, particularly anabolic steroids, in sports and society.

Lancet 2008 May;371(9627):1872-82

Karolinska Institutet, Department of Laboratory Medicine, Division of Clinical Pharmacology, Karolinska University Hospital, Stockholm, Sweden.

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http://dx.doi.org/10.1016/S0140-6736(08)60801-6DOI Listing
May 2008

Incidence and predictors of severe bleeding during warfarin treatment.

J Thromb Thrombolysis 2008 Apr 20;25(2):151-9. Epub 2007 May 20.

Division of Clinical Pharmacology, C1-68, Karolinska University Hospital Huddinge, 14186 Stockholm, Sweden.

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http://dx.doi.org/10.1007/s11239-007-0048-2DOI Listing
April 2008

The UGT2B17 gene deletion is not associated with prostate cancer risk.

Prostate 2008 Apr;68(5):571-5

Department of Urology, Karolinska University Hospital, Stockholm, Sweden.

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http://dx.doi.org/10.1002/pros.20700DOI Listing
April 2008

The uridine diphosphate glucuronosyltransferase 2B15 D85Y and 2B17 deletion polymorphisms predict the glucuronidation pattern of androgens and fat mass in men.

J Clin Endocrinol Metab 2007 Dec 14;92(12):4878-82. Epub 2007 Aug 14.

Center for Bone Research at the Sahlgrenska Academy, Department of Internal Medicine, Göteborg University, SE-41345 Göteborg, Sweden.

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http://dx.doi.org/10.1210/jc.2007-0359DOI Listing
December 2007

Effect of voriconazole on the pharmacokinetics of diclofenac.

Fundam Clin Pharmacol 2007 Dec;21(6):651-6

Department of Pharmacology, Drug Development and Therapeutics, University of Turku and Turku University Hospital, Turku, Finland.

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http://dx.doi.org/10.1111/j.1472-8206.2007.00516.xDOI Listing
December 2007

Expression of CYP3A isoforms and P-glycoprotein in human stomach, jejunum and ileum.

Clin Exp Pharmacol Physiol 2007 Nov;34(11):1138-44

Department of Anatomy, Pharmacology and Forensic Medicine, Division of Pharmacology and Experimental Therapeutics, University of Torino, Torino, Italy.

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http://dx.doi.org/10.1111/j.1440-1681.2007.04691.xDOI Listing
November 2007

Sex steroid levels and cortical bone size in young men are associated with a uridine diphosphate glucuronosyltransferase 2B7 polymorphism (H268Y).

J Clin Endocrinol Metab 2007 Sep 19;92(9):3697-704. Epub 2007 Jun 19.

Center for Bone Research at the Sahlgrenska Academy, Department of Internal Medicine, Gothenburg University, SE-41345 Gothenburg, Sweden.

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http://dx.doi.org/10.1210/jc.2007-0530DOI Listing
September 2007

Regulation and expression of human CYP7B1 in prostate: overexpression of CYP7B1 during progression of prostatic adenocarcinoma.

Prostate 2007 Sep;67(13):1439-46

Department of Urology, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.

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http://dx.doi.org/10.1002/pros.20630DOI Listing
September 2007

Genetic polymorphism of cytochrome P450s and P-glycoprotein in the Finnish population.

Fundam Clin Pharmacol 2007 Aug;21(4):379-86

Department of Pharmacology, Drug Development and Therapeutics, University of Turku, Itäinen Pitkäkatu 4B, 3rd floor, FIN-20520 Turku, Finland.

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http://dx.doi.org/10.1111/j.1472-8206.2007.00494.xDOI Listing
August 2007

Expression of cytochromes P450 3A and P-glycoprotein in human large intestine in paired tumour and normal samples.

Basic Clin Pharmacol Toxicol 2007 Apr;100(4):240-8

Department of Laboratory Medicine, Division of Clinical Pharmacology, Karolinska Institutet, Huddinge University Hospital, Stockholm, Sweden.

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http://dx.doi.org/10.1111/j.1742-7843.2006.00023.xDOI Listing
April 2007

Association of cytochrome P450 1B1 polymorphism with first-trimester miscarriage.

Fertil Steril 2006 Nov 14;86(5):1498-503. Epub 2006 Sep 14.

Department of Medical Laboratory Sciences and Technology, Division of Clinical Pharmacology, Karolinska Institutet, Karolinska University Hospital (Huddinge), Stockholm, Sweden.

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http://dx.doi.org/10.1016/j.fertnstert.2006.03.059DOI Listing
November 2006

Effect of caffeine intake 12 or 24 hours prior to melatonin intake and CYP1A2*1F polymorphism on CYP1A2 phenotyping by melatonin.

Basic Clin Pharmacol Toxicol 2006 Oct;99(4):300-4

Department of Drug Metabolism and Pharmacokinetics, Boehringer-Ingelheim Pharma, Germany.

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http://dx.doi.org/10.1111/j.1742-7843.2006.pto_491.xDOI Listing
October 2006

[Drug committees should not recommend "off label" prescriptions].

Authors:
Anders Rane

Lakartidningen 2006 Apr 12-25;103(15-16):1219

Karolinska Universitetssjukhuset.

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May 2006

Identification of a novel specific CYP2B6 allele in Africans causing impaired metabolism of the HIV drug efavirenz.

Pharmacogenet Genomics 2006 Mar;16(3):191-8

Division of Molecular Toxicology, Institute of Environmental Medicine, Karolinska Institute, Stockholm.

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http://dx.doi.org/10.1097/01.fpc.0000189797.03845.90DOI Listing
March 2006

Large differences in testosterone excretion in Korean and Swedish men are strongly associated with a UDP-glucuronosyl transferase 2B17 polymorphism.

J Clin Endocrinol Metab 2006 Feb 6;91(2):687-93. Epub 2005 Dec 6.

Clinical Pharmacology, C1:68, Karolinska Institutet at Karolinska University Hospital, S-141 86 Stockholm, Sweden.

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http://dx.doi.org/10.1210/jc.2005-1643DOI Listing
February 2006

Inhibitory effect of 5-fluorouracil on cytochrome P450 2C9 activity in cancer patients.

Basic Clin Pharmacol Toxicol 2006 Feb;98(2):197-200

Department of Pharmacology, Gazi University, Medical Faculty, Ankara, Turkey.

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http://dx.doi.org/10.1111/j.1742-7843.2006.pto_304.xDOI Listing
February 2006

Pharmacogenetics of cyclophosphamide in patients with hematological malignancies.

Eur J Pharm Sci 2006 Jan 23;27(1):54-61. Epub 2005 Sep 23.

Department of Laboratory Medicine, Division of Clinical Pharmacology, Karolinska Institutet, SE 141-86 Stockholm, Sweden.

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http://dx.doi.org/10.1016/j.ejps.2005.08.008DOI Listing
January 2006

Polymorphisms of genes CYP2D6, ADRB1 and GNAS1 in pharmacokinetics and systemic effects of ophthalmic timolol. A pilot study.

Eur J Clin Pharmacol 2005 Dec 17;61(11):811-9. Epub 2005 Nov 17.

Department of Pharmacological Sciences, Medical School, University of Tampere, 33014 Tampere, Finland.

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http://dx.doi.org/10.1007/s00228-005-0052-4DOI Listing
December 2005

Several-fold increase in risk of overanticoagulation by CYP2C9 mutations.

Clin Pharmacol Ther 2005 Nov;78(5):540-50

Division of Clinical Pharmacology, Department of Laboratory Medicine, Institute of Environmental Medicine, Karolinska Institutet, Karolinska University Hospital, Huddinge, S-141 86 Stockholm, Sweden.

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http://dx.doi.org/10.1016/j.clpt.2005.08.006DOI Listing
November 2005

A novel polymorphic cytochrome P450 formed by splicing of CYP3A7 and the pseudogene CYP3AP1.

J Biol Chem 2005 Aug 2;280(31):28324-31. Epub 2005 Jun 2.

Division of Molecular Toxicology, Institute of Environmental Medicine, Karolinska Institute, 17177 Stockholm.

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http://dx.doi.org/10.1074/jbc.M502309200DOI Listing
August 2005

Paediatric adverse drug reactions reported in Sweden from 1987 to 2001.

Pharmacoepidemiol Drug Saf 2005 Jul;14(7):493-9

Department of Laboratory Medicine, Division of Clinical Pharmacology, Karolinska Institutet and the Regional adverse drug reaction monitoring centre of the Medical Product Agency, Karolinska University Hospital-Huddinge, Stockholm, Sweden.

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http://doi.wiley.com/10.1002/pds.1121
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July 2005

Cytochromes P450 and MDR1 mRNA expression along the human gastrointestinal tract.

Br J Clin Pharmacol 2005 Jul;60(1):54-60

Centre of Clinical Research, Uppsala University, Central Hospital, Västerås, Sweden.

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http://dx.doi.org/10.1111/j.1365-2125.2005.02389.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1884914PMC
July 2005