Anders Nykjaer

Anders Nykjaer

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Anders Nykjaer

Publications by authors named "Anders Nykjaer"

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Risk Locus Identification Ties Alcohol Withdrawal Symptoms to SORCS2.

Alcohol Clin Exp Res 2018 12 25;42(12):2337-2348. Epub 2018 Oct 25.

Department of Psychiatry , Division of Human Genetics, VA CT Healthcare Center, Yale School of Medicine, New Haven, Connecticut.

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http://dx.doi.org/10.1111/acer.13890DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317871PMC
December 2018

An alternative transcript of the Alzheimer's disease risk gene SORL1 encodes a truncated receptor.

Neurobiol Aging 2018 11 28;71:266.e11-266.e24. Epub 2018 Jun 28.

Danish Research Institute of Translational Neuroscience (DANDRITE) Nordic-EMBL Partnership, Aarhus, Denmark. Electronic address:

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http://dx.doi.org/10.1016/j.neurobiolaging.2018.06.021DOI Listing
November 2018

Biochemical and cognitive effects of docosahexaenoic acid differ in a developmental and SorLA dependent manner.

Behav Brain Res 2018 08 13;348:90-100. Epub 2018 Apr 13.

Department of Biomedicine, Aarhus University, Denmark; Research Initiative on Brain Barriers and Drug Delivery, Aarhus University, Denmark; DANDRITE - Nordic EMBL Partnership for Molecular Medicine, Aarhus University, Denmark. Electronic address:

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http://dx.doi.org/10.1016/j.bbr.2018.04.017DOI Listing
August 2018

Potential genetic modifiers of disease risk and age at onset in patients with frontotemporal lobar degeneration and GRN mutations: a genome-wide association study.

Authors:
Cyril Pottier Xiaolai Zhou Ralph B Perkerson Matt Baker Gregory D Jenkins Daniel J Serie Roberta Ghidoni Luisa Benussi Giuliano Binetti Adolfo López de Munain Miren Zulaica Fermin Moreno Isabelle Le Ber Florence Pasquier Didier Hannequin Raquel Sánchez-Valle Anna Antonell Albert Lladó Tammee M Parsons NiCole A Finch Elizabeth C Finger Carol F Lippa Edward D Huey Manuela Neumann Peter Heutink Matthis Synofzik Carlo Wilke Robert A Rissman Jaroslaw Slawek Emilia Sitek Peter Johannsen Jørgen E Nielsen Yingxue Ren Marka van Blitterswijk Mariely DeJesus-Hernandez Elizabeth Christopher Melissa E Murray Kevin F Bieniek Bret M Evers Camilla Ferrari Sara Rollinson Anna Richardson Elio Scarpini Giorgio G Fumagalli Alessandro Padovani John Hardy Parastoo Momeni Raffaele Ferrari Francesca Frangipane Raffaele Maletta Maria Anfossi Maura Gallo Leonard Petrucelli EunRan Suh Oscar L Lopez Tsz H Wong Jeroen G J van Rooij Harro Seelaar Simon Mead Richard J Caselli Eric M Reiman Marwan Noel Sabbagh Mads Kjolby Anders Nykjaer Anna M Karydas Adam L Boxer Lea T Grinberg Jordan Grafman Salvatore Spina Adrian Oblak M-Marsel Mesulam Sandra Weintraub Changiz Geula John R Hodges Olivier Piguet William S Brooks David J Irwin John Q Trojanowski Edward B Lee Keith A Josephs Joseph E Parisi Nilüfer Ertekin-Taner David S Knopman Benedetta Nacmias Irene Piaceri Silvia Bagnoli Sandro Sorbi Marla Gearing Jonathan Glass Thomas G Beach Sandra E Black Mario Masellis Ekaterina Rogaeva Jean-Paul Vonsattel Lawrence S Honig Julia Kofler Amalia C Bruni Julie Snowden David Mann Stuart Pickering-Brown Janine Diehl-Schmid Juliane Winkelmann Daniela Galimberti Caroline Graff Linn Öijerstedt Claire Troakes Safa Al-Sarraj Carlos Cruchaga Nigel J Cairns Jonathan D Rohrer Glenda M Halliday John B Kwok John C van Swieten Charles L White Bernardino Ghetti Jill R Murell Ian R A Mackenzie Ging-Yuek R Hsiung Barbara Borroni Giacomina Rossi Fabrizio Tagliavini Zbigniew K Wszolek Ronald C Petersen Eileen H Bigio Murray Grossman Vivianna M Van Deerlin William W Seeley Bruce L Miller Neill R Graff-Radford Bradley F Boeve Dennis W Dickson Joanna M Biernacka Rosa Rademakers

Lancet Neurol 2018 06 30;17(6):548-558. Epub 2018 Apr 30.

Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA. Electronic address:

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http://dx.doi.org/10.1016/S1474-4422(18)30126-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6237181PMC
June 2018

Transient denervation of viable myocardium after myocardial infarction does not alter arrhythmia susceptibility.

Am J Physiol Heart Circ Physiol 2018 03 3;314(3):H415-H423. Epub 2017 Nov 3.

Department of Physiology and Pharmacology, Oregon Health and Science University , Portland, Oregon.

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http://www.physiology.org/doi/10.1152/ajpheart.00300.2017
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http://dx.doi.org/10.1152/ajpheart.00300.2017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5899257PMC
March 2018

Hidden Twins: SorCS Neuroreceptors Form Stable Dimers.

J Mol Biol 2017 09 18;429(19):2907-2917. Epub 2017 Aug 18.

Department of Structural Biology, Max Planck Institute of Biophysics, Max-von-Laue-Straße 3, 60438 Frankfurt am Main, Germany; DANDRITE, iNANO, Aarhus University, Gustav Wieds Vej 14, 8000 Aarhus C, Denmark. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00222836173041
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http://dx.doi.org/10.1016/j.jmb.2017.08.006DOI Listing
September 2017

Progranulin gene variation affects serum progranulin levels differently in Danish bipolar individuals compared with healthy controls.

Psychiatr Genet 2017 06;27(3):89-95

aTranslational Neuropsychiatry Unit, Department of Clinical Medicine bDepartment of Biomedicine, The Lundbeck Foundation Research Center, MIND cDepartment of Biomedicine, Danish Research Institute of Translational Neuroscience (DANDRITE), Nordic EMBL Partnership for Molecular Medicine, Aarhus University dDepartment of Psychosis, Psychosis Research Unit, Aarhus University Hospital, Risskov eThe Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus, Denmark fDepartment of Neuroscience, Mayo Clinic, Jacksonville, Florida, USA.

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http://dx.doi.org/10.1097/YPG.0000000000000168DOI Listing
June 2017

Prions amplify through degradation of the VPS10P sorting receptor sortilin.

PLoS Pathog 2017 Jun 30;13(6):e1006470. Epub 2017 Jun 30.

Division of Molecular Neurobiology, Institute for Enzyme Research (KOSOKEN), Tokushima University, Tokushima, Japan.

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http://dx.doi.org/10.1371/journal.ppat.1006470DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5509376PMC
June 2017

Soluble sortilin is present in excess and positively correlates with progranulin in CSF of aging individuals.

Exp Gerontol 2016 11 7;84:96-100. Epub 2016 Sep 7.

Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA; Department of Biomedicine, Aarhus University, Aarhus, Denmark; The Lundbeck Foundation Research Center, MIND, Aarhus, Denmark. Electronic address:

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http://dx.doi.org/10.1016/j.exger.2016.09.002DOI Listing
November 2016

Sorting receptor sortilin-a culprit in cardiovascular and neurological diseases.

J Mol Med (Berl) 2014 Sep 18;92(9):905-11. Epub 2014 May 18.

Max-Delbrueck-Center for Molecular Medicine, Robert-Roessle-Strasse 10, 13125, Berlin, Germany.

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http://link.springer.com/10.1007/s00109-014-1152-3
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http://dx.doi.org/10.1007/s00109-014-1152-3DOI Listing
September 2014

SorCS2 regulates dopaminergic wiring and is processed into an apoptotic two-chain receptor in peripheral glia.

Neuron 2014 Jun;82(5):1074-87

The Lundbeck Foundation Research Center MIND, Department of Biomedicine, Aarhus University, Vennelyst Boulevard 4, 8000 C Aarhus, Denmark; Danish Research Institute of Translational Neuroscience DANDRITE Nordic-EMBL Partnership, Department of Biomedicine, Aarhus University, Vennelyst Boulevard 4, 8000 C Aarhus, Denmark; Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2014.04.022DOI Listing
June 2014

Pro-neurotrophins, sortilin, and nociception.

Eur J Neurosci 2014 Feb;39(3):363-74

Department of Neuroscience, Molecular Physiology of Somatic Sensation Group, Max-Delbrück Center for Molecular Medicine, Robert-Rössle Str. 10, 13122, Berlin, Germany.

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http://dx.doi.org/10.1111/ejn.12466DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4232910PMC
February 2014

The hypercholesterolemia-risk gene SORT1 facilitates PCSK9 secretion.

Cell Metab 2014 Feb;19(2):310-8

The Lundbeck Foundation Research Center, MIND, Department of Biomedicine, Aarhus University, Vennelyst Boulevard 4, DK-8000 C Aarhus, Denmark; Danish Research Institute of Translational Neuroscience DANDRITE, Nordic EMBL Partnership, Department of Biomedicine, Aarhus University, Vennelyst Boulevard 4, DK-8000 C Aarhus, Denmark. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2013.12.006DOI Listing
February 2014

Up-regulation of sortilin mediated by amyloid-β and p75(NTR): safety lies in the middle course.

J Neurochem 2013 Oct 28;127(2):149-51. Epub 2013 Aug 28.

Queensland Brain Institute, Clem Jones Centre for Ageing Dementia Research, The University of Queensland, Brisbane, Queensland, Australia.

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http://dx.doi.org/10.1111/jnc.12389DOI Listing
October 2013

Loss of BDNF or its receptors in three mouse models has unpredictable consequences for anxiety and fear acquisition.

Learn Mem 2013 Sep 1;20(9):499-504. Epub 2013 Sep 1.

The Lundbeck Foundation Research Centre, MIND, Danish Research Institute of Translational Neuroscience DANDRITE, Nordic EMBL Partnership, Department of Biomedicine, Aarhus University, DK-8000C Aarhus, Denmark.

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http://dx.doi.org/10.1101/lm.032045.113DOI Listing
September 2013

Dissecting the role of sortilin receptor signaling in neurodegeneration induced by NGF deprivation.

Biochem Biophys Res Commun 2013 Feb 11;431(3):579-85. Epub 2013 Jan 11.

Laboratory of Neurobiology, Scuola Normale Superiore, Pisa, Italy.

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http://dx.doi.org/10.1016/j.bbrc.2013.01.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3585961PMC
February 2013

Sortilin and SorLA display distinct roles in processing and trafficking of amyloid precursor protein.

J Neurosci 2013 Jan;33(1):64-71

The Lundbeck Foundation Research Centre MIND, Department of Biomedicine, Aarhus University, DK-8000 Aarhus C, Denmark.

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http://dx.doi.org/10.1523/JNEUROSCI.2371-12.2013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6618638PMC
January 2013

Sortilin: a receptor to regulate neuronal viability and function.

Trends Neurosci 2012 Apr 16;35(4):261-70. Epub 2012 Feb 16.

The Lundbeck Foundation Research Centre MIND, Department of Biomedicine, University of Aarhus, Ole Worms Allé 1170, DK-8000 Aarhus C, Denmark.

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http://dx.doi.org/10.1016/j.tins.2012.01.003DOI Listing
April 2012

Retromer binds the FANSHY sorting motif in SorLA to regulate amyloid precursor protein sorting and processing.

J Neurosci 2012 Jan;32(4):1467-80

The Lundbeck Foundation Research Centre MIND, Department of Biomedicine, Aarhus University, and MIND Centre, Stereology and Electron Microscopy Laboratory, Centre for Stochastic Geometry and Advanced Bioimaging, Aarhus University Hospital, DK-8000 Aarhus C, Denmark.

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http://dx.doi.org/10.1523/JNEUROSCI.2272-11.2012DOI Listing
January 2012

Proteolytic processing of the p75 neurotrophin receptor: A prerequisite for signalling?: Neuronal life, growth and death signalling are crucially regulated by intra-membrane proteolysis and trafficking of p75(NTR).

Bioessays 2011 Aug 30;33(8):614-25. Epub 2011 Jun 30.

The Lundbeck Foundation Research Center MIND, Department of Medical Biochemistry, Aarhus University, Aarhus, Denmark.

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http://doi.wiley.com/10.1002/bies.201100036
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http://dx.doi.org/10.1002/bies.201100036DOI Listing
August 2011

Neuronal brain-derived neurotrophic factor is synthesized in excess, with levels regulated by sortilin-mediated trafficking and lysosomal degradation.

J Biol Chem 2011 Aug 5;286(34):29556-67. Epub 2011 Jul 5.

Graduate Program in Neuroscience, Weill Medical College of Cornell University, New York, New York 10065, USA.

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http://dx.doi.org/10.1074/jbc.M111.219675DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3190996PMC
August 2011

The spared nerve injury (SNI) model of induced mechanical allodynia in mice.

J Vis Exp 2011 Aug 18(54). Epub 2011 Aug 18.

The Lundbeck Foundation Research Center MIND, Department of Biomedicine, Aarhus University.

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http://dx.doi.org/10.3791/3092DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3217639PMC
August 2011

Sortilins: new players in lipoprotein metabolism.

Curr Opin Lipidol 2011 Apr;22(2):79-85

Max-Delbrück-Center for Molecular Medicine, Berlin, Germany.

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http://dx.doi.org/10.1097/MOL.0b013e3283416f2bDOI Listing
April 2011

SorLA regulates the activity of lipoprotein lipase by intracellular trafficking.

J Cell Sci 2011 Apr 8;124(Pt 7):1095-105. Epub 2011 Mar 8.

The MIND-Center, Department of Medical Biochemistry, University of Aarhus, Ole Worms Allé 1170, DK 8000 Aarhus C, Denmark.

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http://dx.doi.org/10.1242/jcs.072538DOI Listing
April 2011

APP involvement in retinogenesis of mice.

Acta Neuropathol 2011 Mar 27;121(3):351-63. Epub 2010 Oct 27.

Centre de Recherche des Cordeliers, Université Pierre et Marie Curie, Paris 6, INSERM, 15 rue de l'Ecole de Médecine, Paris, France.

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http://dx.doi.org/10.1007/s00401-010-0762-2DOI Listing
March 2011

Proneurotrophin-3 may induce Sortilin-dependent death in inner ear neurons.

Eur J Neurosci 2011 Feb 24;33(4):622-31. Epub 2011 Jan 24.

Department of Otorhinolaryngology, Aarhus University Hospital, Nørrebrogade 44, 8000 Aarhus C, Denmark.

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http://dx.doi.org/10.1111/j.1460-9568.2010.07556.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3078644PMC
February 2011

Sort1, encoded by the cardiovascular risk locus 1p13.3, is a regulator of hepatic lipoprotein export.

Cell Metab 2010 Sep;12(3):213-23

The Lundbeck Foundation Research Center MIND, Department of Medical Biochemistry, Aarhus University, Denmark.

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http://dx.doi.org/10.1016/j.cmet.2010.08.006DOI Listing
September 2010

Assessing low-dose gentamicin-induced kidney injury in rats by analysis of urine.

J Pharmacol Toxicol Methods 2009 Nov-Dec;60(3):316-20. Epub 2009 Jul 24.

Department of Medical Biochemistry, Aarhus University, DK 8000 Aarhus C, Denmark.

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http://dx.doi.org/10.1016/j.vascn.2009.07.006DOI Listing
July 2010

Golgi-to-phagosome transport of acid sphingomyelinase and prosaposin is mediated by sortilin.

J Cell Sci 2010 Jul 22;123(Pt 14):2502-11. Epub 2010 Jun 22.

European Molecular Biology Laboratory, Postfach 102209, 69117 Heidelberg, Germany.

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http://dx.doi.org/10.1242/jcs.067686DOI Listing
July 2010

Identification of a linear epitope in sortilin that partakes in pro-neurotrophin binding.

J Biol Chem 2010 Apr 16;285(16):12210-22. Epub 2010 Feb 16.

Department of Medical Biochemistry, Membrane Receptors in Neuronal Disease (MIND) Center, University of Aarhus, OleWorms Allé, Aarhus C, Denmark.

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http://dx.doi.org/10.1074/jbc.M109.062364DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2852960PMC
April 2010

Cellular uptake of steroid carrier proteins--mechanisms and implications.

Mol Cell Endocrinol 2010 Mar 29;316(1):93-102. Epub 2009 Jul 29.

Max-Delbrück-Center for Molecular Medicine, Berlin, Germany.

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http://dx.doi.org/10.1016/j.mce.2009.07.021DOI Listing
March 2010

Preservation of cortical sortilin protein levels in MCI and Alzheimer's disease.

Neurosci Lett 2010 Mar 18;471(3):129-33. Epub 2010 Jan 18.

Department of Neurological Sciences, Rush University Medical Center, Chicago, IL 60612, USA.

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http://dx.doi.org/10.1016/j.neulet.2010.01.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2829104PMC
March 2010

Brain-derived neurotrophic factor reduces amyloidogenic processing through control of SORLA gene expression.

J Neurosci 2009 Dec;29(49):15472-8

Max Delbrueck Center for Molecular Medicine, Charité-Universitätsmedizin Berlin, D-13125 Berlin, Germany.

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http://dx.doi.org/10.1523/JNEUROSCI.3960-09.2009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6666105PMC
December 2009

Cubilin and megalin co-localize in the neonatal inner ear.

Audiol Neurootol 2009 6;14(4):267-78. Epub 2009 Feb 6.

Department of Otorhinolaryngology, Aarhus University Hospital, Aarhus, Denmark.

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http://dx.doi.org/10.1159/000199446DOI Listing
June 2009

VPS10P-domain receptors - regulators of neuronal viability and function.

Nat Rev Neurosci 2008 Dec 12;9(12):899-909. Epub 2008 Nov 12.

Max-Delbrueck-Center for Molecular Medicine, Robert-Roessle-Strasse 10, D-13125 Berlin, Germany.

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http://dx.doi.org/10.1038/nrn2516DOI Listing
December 2008

Roles for the pro-neurotrophin receptor sortilin in neuronal development, aging and brain injury.

Nat Neurosci 2007 Nov 14;10(11):1449-57. Epub 2007 Oct 14.

MIND Center, Department of Medical Biochemistry, Ole Worms Allé 1170, Aarhus University, DK-8000 Aarhus C, Denmark.

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http://dx.doi.org/10.1038/nn2000DOI Listing
November 2007

Tumour necrosis factor alpha-converting enzyme mediates ectodomain shedding of Vps10p-domain receptor family members.

Biochem J 2006 Apr;395(2):285-93

Institute of Medical Biochemistry, MIND Center, Ole Worms Allé, Building 1170, University of Aarhus, 8000 Arhus C, Denmark.

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http://dx.doi.org/10.1042/BJ20051364DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1422770PMC
April 2006

p75NTR--live or let die.

Curr Opin Neurobiol 2005 Feb;15(1):49-57

Department of Medical Biochemistry, Ole Worms Allé Building. 170, Aarhus University, DK-8000C Aarhus, Denmark.

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http://dx.doi.org/10.1016/j.conb.2005.01.004DOI Listing
February 2005

Functional organization of the sortilin Vps10p domain.

J Biol Chem 2004 Nov 10;279(48):50221-9. Epub 2004 Sep 10.

Institute of Medical Biochemistry, Ole Worms Allé, Building 170, University of Aarhus, Aarhus, Denmark.

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http://dx.doi.org/10.1074/jbc.M408873200DOI Listing
November 2004

Sortilin is essential for proNGF-induced neuronal cell death.

Nature 2004 Feb;427(6977):843-8

Department of Medical Biochemistry, Ole Worms Allé 170, Aarhus University, Gustav Wieds vej 10, DK-8000 Aarhus C, Denmark.

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http://dx.doi.org/10.1038/nature02319DOI Listing
February 2004

From holoprosencephaly to osteopathology: role of multifunctional endocytic receptors in absorptive epithelia.

Ann Med 2003 ;35(5):290-9

Department of Pediatric Nephrology, Charité Children's Hospital, Humbolt University, Berlin, Germany.

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December 2003

Expression profiling confirms the role of endocytic receptor megalin in renal vitamin D3 metabolism.

Kidney Int 2002 Nov;62(5):1672-81

Max-Delbrueck-Center for Molecular Medicine and Medical Faculty of the Free University of Berlin, Berlin, Germany.

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http://linkinghub.elsevier.com/retrieve/pii/S008525381548723
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http://dx.doi.org/10.1046/j.1523-1755.2002.00634.xDOI Listing
November 2002

Pathways for kidney-specific uptake of the steroid hormone 25-hydroxyvitamin D3.

Curr Opin Lipidol 2002 Jun;13(3):255-60

Max Delbrück Center for Molecular Medicine and Medical Faculty of the Free University of Berlin, Germany.

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June 2002

The low-density lipoprotein receptor gene family: a cellular Swiss army knife?

Trends Cell Biol 2002 Jun;12(6):273-80

Dept of Medical Biochemistry, University of Aarhus, DK-8000, Aarhus C, Denmark.

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June 2002