Publications by authors named "Andee Dzulkarnaen"

6 Publications

  • Page 1 of 1

Re: Perforated descending colon adenocarcinoma manifesting as necrotizing fasciitis.

ANZ J Surg 2021 04;91(4):763-764

Department of Surgery, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia.

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http://dx.doi.org/10.1111/ans.16536DOI Listing
April 2021

Detection of microplastics in human colectomy specimens.

JGH Open 2021 Jan 21;5(1):116-121. Epub 2020 Nov 21.

School of Medical Sciences Universiti Sains Malaysia Kota Bharu Malaysia.

Background And Aim: While dietary exposure to microplastics is increasingly recognized, it is unknown if ingested plastics remain within the digestive tract. We aimed to examine human colectomy specimens for microplastics and to report the characteristics as well as polymer composition of the particles.

Methods: Colectomy samples were obtained from 11 adults (mean age 45.7, six males) who were residents of Northeastern Peninsular Malaysia. Microplastics were identified following chemical digestion of specimens and subsequent filtration. The samples were then examined for characteristics (abundance, length, shape, and color) and composition of three common polymer types using stereo- and Fourier Transform InfraRed (FTIR) microscopes.

Results: Microplastics were detected in all 11 specimens with an average of 331 particles/individual specimen or 28.1 ± 15.4 particles/g tissue. Filaments or fibers accounted for 96.1% of particles, and 73.1% of all filaments were transparent. Out of 40 random filaments from 10 specimens (one had indeterminate spectra patterns), 90% were polycarbonate, 50% were polyamide, and 40% were polypropylene.

Conclusion: Our study suggests that microplastics are ubiquitously present in the human colon.
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http://dx.doi.org/10.1002/jgh3.12457DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7812470PMC
January 2021

Perforated caecal mass: benign or malignant?

ANZ J Surg 2021 Jul 22;91(7-8):1620-1622. Epub 2020 Dec 22.

Department of Surgery, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia.

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http://dx.doi.org/10.1111/ans.16508DOI Listing
July 2021

Snakehead Consumption Enhances Wound Healing? From Tradition to Modern Clinical Practice: A Prospective Randomized Controlled Trial.

Evid Based Complement Alternat Med 2018 14;2018:3032790. Epub 2018 Nov 14.

Surgery Department, Indra Gandhi Memorial Hospital, Kanbaa Aisa Rani Higun, Malé, Maldives.

Background: Snakehead fish ( is a fresh water fish indigenous to many Asia countries and believed to have medical value. Studies showed that it contains all the essential amino acids and fatty acids able to accelerate wound healing and it has antinociceptive effect. However, little human study has been done to assess the effectiveness of in wound healing. A prospective RCT has been conducted on the effect of spray versus placebo on clean wound to assess its pain control effect and cosmetic outcome.

Methodology: One hundred and two patients (102) underwent clean elective surgery; postoperatively they were randomized into two group. One group received extract spray (n=51) another group received placebo (n=51) on daily basis for 2 weeks. They were followed up on 2, 4, and 6 weeks. Pain control effect was assessed based on Visual Analog Pain Score (VAPS) and cosmetic outcome based on Visual Analog Cosmetic Scale (VACS), Wound Evaluation Scale (WES), and Vancouver Scar Scale (VSS).

Result: The patient treated with spray displayed a better outcome in terms of pain control compared to placebo. During analysis using repeated measure ANOVA, there was significant difference of patient's pain score based on VAPS between spray and placebo (F-stat (df) = 4.80 (2), p-value = 0.010). For cosmetic outcome it showed a better result in spray group for all the 3-scoring system, VACS, (F-stat (df) = 2.68 (2) , p-value <0.001), WES (F-stat (df) = 3.09 (2), p-value = 0.048), and VSS (F-stat (df) = 1.72 (2) , p-value = 0.011).

Conclusion: Our study suggest that application of extract spray on clean wound has shown a significant better pain score result and cosmetic outcome on week 2, week 4, and week 6 comparatively with placebo.
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http://dx.doi.org/10.1155/2018/3032790DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6261081PMC
November 2018

Prevalence of Helicobacter pylori cagA, babA2, and dupA genotypes and correlation with clinical outcome in Malaysian patients with dyspepsia.

Turk J Med Sci 2015 ;45(4):940-6

Background/aim: The severity of disease outcome in dyspepsia has been attributed to Helicobacter pylori virulence genes. The aim of this study was to determine the distribution of H. pylori virulence genes (cagA, babA2, and dupA) and to determine whether or not there arises a significant correlation with clinical dyspepsia outcomes.

Materials And Methods: H. pylori genotypes cagA, babA2, and dupA were identified by polymerase chain reactions from gastric biopsy samples in 105 H. pylori-positive patients.

Results: The positive rates for cagA, babA2, and dupA genes in H. pylori dyspeptic patients were 69.5%, 41.0%, and 22.9%, respectivel cagA was more prevalent in Indians (39.7%), babA2 was more prevalent in Malays (39.5%), and dupA detection occurred more frequently in both Indians and Malays and at the same rate (37.5%). The Chinese inhabitants had the lowest prevalence of the three genes. Nonulcer disease patients had a significantly higher distribution of cagA (76.7%), babA2 (74.4%), and dupA (75.0%). There was no apparent association between these virulence genes and the clinical outcomes.

Conclusion: The lower prevalence of these genes and variations among different ethnicities implies that the strains are geographically and ethnically dependent. None of the virulence genes were knowingly beneficial in predicting the clinical outcome of H. pylori infection in our subjects.
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http://dx.doi.org/10.3906/sag-1409-77DOI Listing
October 2015

Evaluation of the Atlas Helicobacter pylori stool antigen test for diagnosis of infection in adult patients.

Asian Pac J Cancer Prev 2014 ;15(13):5245-7

Department of Medical Microbiology and Parasitology, School of Medical Sciences, Universiti Sains Malaysia, Kelantan, Malaysia E-mail :

Background: Helicobacter pylori (H. pylori) is one of the most important causes of dyspepsia and gastric cancer and diagnosis can be made by invasive or non-invasive methods. The Atlas Helicobacter pylori antigen test is a new rapid non-invasive method which is simple to conduct. The aim of this study was to determine its sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and accuracy.

Materials And Methods: This prospective study was conducted between July 2012 and December 2013. Stool samples of 59 dyspeptic patients who underwent upper endoscopy were evaluated for H. pylori stool antigen.

Results: From the 59 patients who participated in this study, there were 36 (61%) males and 23 (39%) females. H. pylori was diagnosed in 24 (40.7%) gastric biopsies, 22 (91.7 %) of these being positive for the Atlas H. pylori antigen test. The sensitivity, specificity, PPV, NPV and accuracy were 91.7%, 100%, 100%, 94.6% and 96.6% respectively.

Conclusions: The Atlas H. pylori antigen test is a new non-invasive method which is simple to perform and avails reliable results in a few minutes. Thus it can be the best option for the diagnosis of H. pylori infection due to its high sensitivity and specificity.
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http://dx.doi.org/10.7314/apjcp.2014.15.13.5245DOI Listing
April 2015
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