Publications by authors named "Ancuta Marta"

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Clinical heterogeneity among pediatric patients with autoimmune type 1 diabetes stratified by immunoglobulin deficiency.

Pediatr Diabetes 2021 Apr 10. Epub 2021 Apr 10.

Department of Pediatrics, Oncology and Hematology, Medical University of Łódź, Sporna Str., Łódź, Poland.

Background: Type 1 diabetes (T1D) may coexist with primary immunodeficiencies, indicating a shared genetic background.

Objective: To evaluate the prevalence and clinical characteristics of immunoglobulin deficiency (IgD) among children with T1D.

Methods: Serum samples and medical history questionnaires were obtained during routine visits from T1D patients aged 4-18 years. IgG, IgA, IgM, and IgE were measured by nephelometry and ELISA. IgG and IgM deficiency (IgGD, IgMD) were defined as IgG/IgM > 2 standard deviations (SD) below age-adjusted mean. IgE deficiency was defined as IgE<2kIU/l. IgA deficiency (IgAD) was defined as IgA>2SD below age-adjusted mean irrespective of other immunoglobulin classes (absolute if <0.07 g/l, partial otherwise) and as selective IgAD when IgA>2SD below age-adjusted mean with normal IgG and IgM (absolute if <0.07 g/l, partial otherwise).

Results: Among 395 patients (53.4% boys) with the median age of 11.2 (8.4 - 13.7) and diabetes duration 3.6 (1.1 - 6.0) years, 90 (22.8%) were found to have hypogammaglobulinemia. The IgGD and IgAD were the most common each in 40/395 (10.1%). Complex IgD was found in 7 patients. Increased odds of infection-related hospitalization (compared to children without any IgD) was related to having any kind of IgD and IgAD; OR(95%CI)=2.1 (1.2-3.7) and 3.7 (1.8-7.5), respectively. Furthermore, IgAD was associated with having a first-degree relative with T1D OR(95%CI)=3.3 (1.4-7.6) and suffering from non-autoimmune comorbidities 3.3 (1.4 - 7.6), especially neurological disorders 3.5 (1.2 - 10.5).

Conclusions: IgDs frequently coexist with T1D and may be associated with several autoimmune and non-immune related disorders suggesting their common genetic background. This article is protected by copyright. All rights reserved.
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April 2021