Publications by authors named "Anca E Chiriac"

24 Publications

  • Page 1 of 1

Chloronychia in Healthcare Workers in COVID-19 Times.

Skin Appendage Disord 2021 Jan 3;7(1):80-81. Epub 2020 Nov 3.

Department of Dermatology and Allergology, Städtisches Klinikum Dresden, Academic Teaching Hospital of the Technical University of Dresden, Dresden, Germany.

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http://dx.doi.org/10.1159/000511193DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7705944PMC
January 2021

Koebner Phenomenon Induced by Face Mask Ear Loops.

Maedica (Bucur) 2020 Dec;15(4):561-562

Academic Teaching Hospital Dresden-Friedrichstadt, Dermatology, Venereology and Allergology, Dresden, 01076, Germany.

We present a case of Koebner phenomenon induced by friction due to tightness of ear loops attached to the face mask used as protective measure against spreading COVID-19 infection.
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http://dx.doi.org/10.26574/maedica.2020.15.4.561DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7879359PMC
December 2020

Raman Spectroscopy, X-ray Diffraction, and Scanning Electron Microscopy as Noninvasive Methods for Microstructural Alterations in Psoriatic Nails.

Molecules 2021 Jan 8;26(2). Epub 2021 Jan 8.

Centre of Advanced Research in Bionanoconjugates and Biopolymers, "Petru Poni" Institute of Macromolecular Chemistry, 700487 Iași, Romania.

Psoriasis is a chronic inflammatory disease associated with immune system dysfunction that can affect nails, with a negative impact on patient life quality. Usually, nail psoriasis is associated with skin psoriasis and is therefore relatively simple to diagnose. However, up to 10% of nail psoriasis occurs isolated and may be difficult to diagnose by means of current methods (nail biopsy, dermoscopy, video dermoscopy, capillaroscopy, ultrasound of the nails, etc.). Since the nail is a complex biological tissue, mainly composes of hard α-keratins, the structural and morphological techniques can be used to analyze the human fingernails. The aim of this study was to corroborate the information obtained using Raman spectroscopy with those obtained by scanning electron microscopy (SEM) and X-ray diffractometry and to assess the potential of these techniques as non-invasive dermatologic diagnostic tools and an alternative to current methods.
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http://dx.doi.org/10.3390/molecules26020280DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7826832PMC
January 2021

Flare-up of Rosacea due to Face Mask in Healthcare Workers During COVID-19.

Maedica (Bucur) 2020 Sep;15(3):416-417

Department of Epidemiology, "Grigore T. Popa" University of Medicine and Pharmacy Iasi, Romania.

COVID-19 (SARS-COV-2) pandemic is associated with aggravation of facial dermatoses caused by professional prophylactic measures, mostly face masks, especially reported in healthcare workers, such as irritant and contact dermatitis, seborrheic dermatitis, rosacea, acne. We present a case of flare-up of rosacea in a nurse working in an Intensive Care Unit for COVID-19 patients, using FFP1 type mask at work and textile or paper mask outside the hospital.
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http://dx.doi.org/10.26574/maedica.2020.15.3.416DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7726500PMC
September 2020

Mutations of filament-aggregating protein gene in Romanian children diagnosed with atopic dermatitis.

Exp Ther Med 2020 Dec 15;20(6):212. Epub 2020 Oct 15.

Department of Epidemiology, 'Grigore T. Popa' University of Medicine and Pharmacy, 700115 Iasi, Romania.

Association of atopic dermatitis (AD) and several mutations of various genes of the immune system, in particular filament-aggregating protein gene (FLG) has been investigated in many studies. The association between defective FLG and AD in the Romanian population has not been assessed or published. The present study focused on the genetic background of AD, aiming to assess the prevalence of FLG mutations in Romanian patients with AD. Genetic background of AD was tested for common FLG-mutations: R501X, 2282del4, S3247X and R2447X. The study involved 48 Romanian Caucasian children aged between two months and six years diagnosed with AD, and 48 healthy volunteers; DNA extraction involved 50% of the patients to give samples by using buccal swabs and 50% by collection of whole blood samples. Genetic predisposition was evaluated based on family history, atopy history and profilaggrin genotyping. DNA extracted from blood samples was adequate to study FLG mutations, although no mutation was identified. Genetic factors do not have a unique critical role in AD; therefore, environmental factors unquestionably play an important role in this disease, but the clear-cut part that these factors trigger toward increasing the risk of AD in childhood is still obscure.
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http://dx.doi.org/10.3892/etm.2020.9343DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7604754PMC
December 2020

Malignant Degeneration of Scars.

Cancer Manag Res 2020 19;12:10297-10302. Epub 2020 Oct 19.

Department of Epidemiology, Faculty of Medicine, "Grigore T. Popa" University of Medicine and Pharmacy, Iași, Romania.

"Marjolin's ulcer" is known as malignant degeneration of ancient burn scars, but both words can induce misdiagnosis. Malignant degeneration of scarring tissue can occur and can vary in its clinical, histological manifestations and its pre-existing skin lesions. We present several cases to substantiate our observations. "Marjolin's ulcer" is not synonym to an ulceration appeared on an old burn scar, transformed into squamous cell carcinoma.
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http://dx.doi.org/10.2147/CMAR.S274470DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7585506PMC
October 2020

Disseminated cutaneous herpes zoster-A frequently misdiagnosed entity.

Int Wound J 2020 Aug 15;17(4):1089-1091. Epub 2020 Apr 15.

Department of Pathology, University of Medicine, Pharmacy, Sciences and Technology of Tîrgu Mureş, Târgu Mureş, Romania.

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http://dx.doi.org/10.1111/iwj.13370DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7949284PMC
August 2020

New insights into human hair: SAXS, SEM, TEM and EDX for Alopecia Areata investigations.

PeerJ 2020 14;8:e8376. Epub 2020 Jan 14.

Centre of Advanced Research in Bionanoconjugates and Biopolymers, "Petru Poni" Institute of Macromolecular Chemistry, Iasi, Iasi, Romania.

Background: Alopecia areata (AA) is a T-cell-mediated autoimmune disease and affects up to 2% of the population. There is a need for a more profound and rigorous understanding of the structure and composition of human hair affected by AA in order to manage this disease. The aim of this article is to understand the effects of AA on the structure and composition of human hair.

Methods: Several physico-chemical investigation methods, such as Scanning Electron Microscopy (SEM), Transmission Electron Microscopy (TEM), Energy-Dispersive X-ray Spectroscopy (EDX), and microbeam Small Angle X-ray Scattering (SAXS), were used to analyze human hair samples obtained from healthy donors and patients with AA.

Results: SEM revealed more severe hair surface defects for the white regrown hair (W-AA) samples. TEM showed the presence of air-like vesicles located in the endocuticle of regrown hair. Analysis of ultrathin sections of W-AA showed the existence of empty vesicles and smaller melanin granules compared to control samples. SAXS demonstrated that unaffected hair of patients with AA (B-AA) and W-AA melanin aggregates are different in their sizes and shapes compared to the control samples. EDX data showed that W-AA elemental composition was significantly different from the other sample groups. Our study showcases promising non-invasive techniques for a better and more accurate understanding of changes in the internal structure and composition of hair affected by AA.
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http://dx.doi.org/10.7717/peerj.8376DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6968496PMC
January 2020

Sacral (S1) herpes zoster.

J Pain Res 2019 10;12:1475-1477. Epub 2019 May 10.

The Department of Pathology, The University of Medicine and Pharmacy of Tîrgu Mureș, Tîrgu Mureș, Romania.

Herpes zoster usually affects the thoracic and lumbar vertebra (T3-L3), while sacral herpes zoster has been very rarely reported. We present a very rare case of herpes zoster involving S1 dermatome in a 35-year-old healthy man who presented aching pain and typical herpes zoster eruption on the lateral aspect of the calcaneus, lateral plantar area and dorsal aspect of digits III and IV.
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http://dx.doi.org/10.2147/JPR.S199124DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6519706PMC
May 2019

"Chemical" surgery in treating basal cell carcinoma in elderly.

Dermatol Ther 2019 01 16;32(1):e12753. Epub 2018 Oct 16.

"Nicolae Testemitanu" State University of Medicine and Pharmacy, Department of Dermatovenereology, Kishinev, Republic of Moldova.

The incidence of basal cell carcinoma (BCC) has been increasing in the last decades due to population aging and precise diagnosis. The difficulty that physicians face frequently is related to the treatment decision for BCC; when treating BCC, correct and personalized choices must be taken into consideration by selecting from a large variety of therapeutic options such as: surgical excision ("the golden standard therapy"), electrodessication, cryosurgery, radiation therapy, laser, photodynamic therapy, curettage, topical treatment (imiquimod, 5-fluorouracil, vismodegib), or combining different treatments. The present authors present series of cases of patients diagnosed with BCC, highlighting that "chemical surgery" using 70% trichloroacetic acid could be a valuable option in the treatment of nonaggressive BCC of the face.
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http://dx.doi.org/10.1111/dth.12753DOI Listing
January 2019

Home remedies for skin tags: Not recommended!

Int J Clin Pract 2018 07 19;72(7):e13209. Epub 2018 Jun 19.

The University of Medicine and Pharmacy of Tirgu Mures, Tirgu Mures, Romania.

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http://dx.doi.org/10.1111/ijcp.13209DOI Listing
July 2018

First Report of Pachyonychia Congenita Type PC-K6a in the Romanian Population.

Maedica (Bucur) 2017 Jun;12(2):123-126

Pachyonychia Congenita Project, Salt Lake City, Utah, USA.

Pachyonychia congenita (PC) is a rare autosomal dominant skin disorder, with unknown prevalence, although it is estimated there are between 2,000 and 10,000 cases of PC worldwide. The International PC Research Registry (IPCRR) has currently identified (as of November 2016) 746 individuals (in 403 families) with genetically confirmed PC. Heterozygous mutations, predominantly missense mutations, in any one of five keratin genes, KRT6A, KRT6B, KRT6C, KRT16, or KRT17 cause PC. The predominant clinical findings include plantar keratoderma, plantar pain and variable dystrophy of some or all toenails and/ or fingernails. Oral leukokeratosis, follicular hyperkeratosis, cysts of various types and natal teeth may also be present. We report the first case of genetically confirmed PC from Romania due to a mutation in KRT6A, p.Arg466Pro.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5649033PMC
June 2017

Self-medication garlic-induced irritant skin lesions - case series.

Int Wound J 2017 Dec 25;14(6):1407-1408. Epub 2017 Sep 25.

Department of Pathology, University of Medicine of Tirgu Mures, Tirgu Mures, Romania.

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http://dx.doi.org/10.1111/iwj.12818DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7949515PMC
December 2017

Pragmatic management of (suspected allergic) diaper dermatitis.

Contact Dermatitis 2017 Feb;76(2):129-130

Department of Pathology, University of Medicine Targu Mures, Tirgu Mures, 540099, Romania.

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http://dx.doi.org/10.1111/cod.12663DOI Listing
February 2017

Allergic Contact Dermatitis from Topical Acyclovir: Case Series.

J Emerg Med 2017 Feb 19;52(2):e37-e39. Epub 2016 Sep 19.

Department of Pathology, University of Medicine and Pharmacy of Tirgu Mures, Tirgu Mures, Romania.

Background: Despite the widespread use of oral or topical acyclovir, allergic contact dermatitis caused by it has been rarely reported, with fewer than 20 case studies published in the English literature to date.

Case Reports: A diagnosis of allergic contact dermatitis from acyclovir cream was established in a 62-year-old female patient who had been continuously using acyclovir cream for 3 weeks after systemic therapy for herpes zoster with acyclovir, and in a 35-year-old female patient, who had undergone liver transplantation in 2008 and subsequently developed a severe form of herpes zoster treated orally with 4 g/day acyclovir and prolonged topical administration of acyclovir cream. In both cases, patch tests were performed with extended European Baseline Series, with the excipients of acyclovir cream (propylene glycol, sodium lauryl sulfate, cetostearyl alcohol, dimethyl sulfoxide) and commercial cream containing acyclovir 2%. Positive reactions were obtained only with the commercial cream with acyclovir 2%. WHY SHOULD AN EMERGENCY PHYSICIAN BE AWARE OF THIS?: Allergic contact dermatitis caused by acyclovir is rarely reported and frequently misdiagnosed, despite the wide use of oral or topical acyclovir. Allergic contact dermatitis due to acyclovir applied topically is a clinical problem with which health care providers should be familiar, and which prompts patch testing in suspected patients. Knowledge and education focused on allergens are important to clinicians in daily practice.
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http://dx.doi.org/10.1016/j.jemermed.2016.07.083DOI Listing
February 2017

Cutaneous larva migrans in a temperate area.

Arch Dis Child 2016 Sep 2;101(9):813. Epub 2016 Jun 2.

Department of Pathology, University of Medicine and Pharmacy of Targu-Mures, Targu-Mures, Romania.

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http://dx.doi.org/10.1136/archdischild-2016-310845DOI Listing
September 2016

Degradation Mechanism Induced by Psoriasis in Human Fingernails: A Different Approach.

J Invest Dermatol 2016 Jan;136(1):311-3

Centre of Advanced Research in Bionanoconjugates and Biopolymers, "Petru Poni" Institute of Macromolecular Chemistry of Romanian Academy, Iasi, Romania. Electronic address:

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http://dx.doi.org/10.1038/JID.2015.387DOI Listing
January 2016

Diabetic dermopathy ("shin spots") and diabetic bullae ("bullosis diabeticorum") at the same patient.

Pak J Med Sci 2015 Sep-Oct;31(5):1275-6

Prof. Anca Chiriac, MD, PhD. Department of Dermatology, University Apollonia, Nicolina Medical Center, "P.Poni" Research Institute, Iasi, Romania.

We present a diabetic patient with associated two diabetic dermatoses: diabetic dermopathy ("shin spots") and diabetic bullae. A 34-year-old man, with long history of diabetes mellitus, hypertension, and moderate obesity presented to Dermatology Unit for diagnosis of his skin lesions. On clinical examination multiple, light brown, irregular patches, with atrophic scars and crusts over large bullae were observed on the anterior aspect of both legs.
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http://dx.doi.org/10.12669/pjms.315.7521DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4641298PMC
December 2015

Why Is Tinea an Annular Lesion With Centrifugal Growth?

Int J Surg Pathol 2015 Dec 17;23(8):652-3. Epub 2015 Sep 17.

University of Medicine and Pharmacy of Tirgu Mures, Tirgu Mures, Romania.

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http://dx.doi.org/10.1177/1066896915606972DOI Listing
December 2015

Common psychocutaneous disorders in children.

Neuropsychiatr Dis Treat 2015 9;11:333-7. Epub 2015 Feb 9.

Gr T Popa University of Medicine and Pharmacy, Iași, Romania.

The prevalence of psychosomatic disorders among dermatological patients is high but frequently unreported because of difficulties in diagnosing and treating this patient group. Psychiatric and psychological factors may play different roles in the pathogenic mechanism of some skin diseases. The mainstay of diagnosis and treatment is the differentiation between skin disorders associated with psychiatric illness and those of a purely psychiatric nature. Dermatologists and psychiatrists should be aware of this pathology and work together as a team to resolve difficult cases, especially in children. The present paper highlights the psychocutaneous diseases most frequently seen by dermatologists in pediatric population.
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http://dx.doi.org/10.2147/NDT.S78522DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4332316PMC
February 2015

Aplasia cutis congenita of the scalp--what are the steps to be followed? Case report and review of the literature.

An Bras Dermatol 2015 Jan-Feb;90(1):100-3

Nicolina Medical Center, Iasi, Romania.

Aplasia cutis congenita is a rare malformation characterized by localized congenital absence of the skin. It rarely occurs on the trunk and limbs, and can occur in isolation or as part of a heterogeneous group of syndromes. We report a case of a 4-day-old boy with a 5.6-cm- diameter tumor, with a central crust, non-indurate and no inflammatory rim; localized on the scalp and a small, atrophic hairless scar appeared 6 months later (approximately 5 cm in length) at the site of the previous tumor.
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http://dx.doi.org/10.1590/abd1806-4841.20153078DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4323704PMC
July 2015

Autosensitisation (Autoeczematisation) reactions in a case of diaper dermatitis candidiasis.

Niger Med J 2014 May;55(3):274-5

Student, University of Medicine and Pharmacy "Grigore T. Popa", Str. Universitatii nr. 16, Iasi, Romania.

Diaper dermatitis is the most common cutaneous diagnosis in infants. Most cases are associated with the yeast colonisation of Candida or diaper dermatitis candidiasis (DDC). It is an irritating and inflammatory acute dermatitis in the perineal and perianal areas resulting from the occlusion and irritation caused by diapers. Autoeczematization to a distant focus of dermatophyte infection very rarely presents as DDC. We present a 1-month-old boy with lesion on diaper area (gluteal area, perineum, groin and genitalia) and with clusters of pustules and vesicles on a large erythematous base over the dorsal area of both hands.
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http://dx.doi.org/10.4103/0300-1652.132070DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4089061PMC
May 2014

Lichen planus secondary complications associated with the use of biologic therapy for rheumatoid arthritis.

Rom J Morphol Embryol 2013 ;54(3 Suppl):829-31

Department of Surgery, "Grigore T. Popa" University of Medicine and Pharmacy, Iassy, Romania;

Objectives: Biologic therapy such as Etanercept, which is a tumor necrosis factor alpha (TNF-α) inhibitor, has been extensively used as election therapy in rheumatoid arthritis. The purpose of this case presentation was to inform about the possibility that lichen planus lesions could potentially become complicated by secondary infections in patients treated with Etanercept. Furthermore, we aimed at analyzing if the complication of the cutaneous lesion was coincidental or it was due to the immunosuppressive systemic therapy, and whether the infected lesion would respond to antibiotic therapy.

Case Summary: The patient was a 59-year-old woman with rheumatoid arthritis and that have had lichen planus lesions for approximately 25 years. Only recently, she had been received immunosuppressive therapy (Etanercept and Methotrexate). Further on, the lichen planus flared up with a secondary infection determined by a Methicillin-sensitive Staphylococcus aureus. Uncommon myocardial complications were also characteristic of this case.

Results: While a case report described already the appearance of lichen planus following Etanercept therapy (Battistella M et al., 2008), the possibility that the lesion could become secondary complicated following this therapy was never reported before, according to our knowledge. Additionally, we describe in this case the interplay between Etanercept therapy and hypertrophic cardiomyopathy.

Conclusions: Our case is not a lichen planus induced by Etanercept, but it is aggravated and secondary infected with Methicillin-sensitive Staphylococcus during the therapy. The additional cardiac complication (hypertrophic cardiomyopathy) may represent solely an evolutive sign of rheumatoid arthritis and therefore not influenced by Etanercept.
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July 2014

The puzzled low prevalence of atopic dermatitis in kindergarten children in Romania.

Pediatr Allergy Immunol 2014 Feb 1;25(1):96-7. Epub 2013 Dec 1.

Department of Dermatology, Nicolina Medical Center, Iasi, Romania.

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http://dx.doi.org/10.1111/pai.12157DOI Listing
February 2014