Anatol Kontush

Anatol Kontush

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Anatol Kontush

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Glycosylation of human plasma lipoproteins reveals a high level of diversity, which directly impacts their functional properties.

Biochim Biophys Acta Mol Cell Biol Lipids 2019 May 12;1864(5):643-653. Epub 2019 Jan 12.

Genos Glycoscience Research Laboratory, Borongajska cesta 83H, HR-10 000 Zagreb, Croatia.

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https://linkinghub.elsevier.com/retrieve/pii/S13881981193000
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http://dx.doi.org/10.1016/j.bbalip.2019.01.005DOI Listing
May 2019

HDL-Targeted Therapies During Myocardial Infarction.

Cardiovasc Drugs Ther 2019 Feb 18. Epub 2019 Feb 18.

National Heart, Lung and Blood Institute, National Institutes of Health, 10 Center Dr. Building 10 8N222, Bethesda, MD, USA.

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http://dx.doi.org/10.1007/s10557-019-06865-1DOI Listing
February 2019

Distinct phospholipid and sphingolipid species are linked to altered HDL function in apolipoprotein A-I deficiency.

J Clin Lipidol 2019 Feb 25. Epub 2019 Feb 25.

UMR-ICAN 1166, National Institute for Health and Medical Research (INSERM), Sorbonne University, Paris, France. Electronic address:

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http://dx.doi.org/10.1016/j.jacl.2019.02.004DOI Listing
February 2019

Cholesterol efflux capacity of large, small and total HDL particles is unaltered by atorvastatin in patients with type 2 diabetes.

Atherosclerosis 2018 Oct 24;277:72-79. Epub 2018 Aug 24.

Unidad de Investigación de Enfermedades Metabólicas, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Avenue Vasco de Quiroga 15, Tlalpán, CP 14080, Mexico City, Mexico; Departamento de Endocrinología y Metabolismo, Instituto Nacional de Ciencias Médicas y Nutrición Salvador, Avenue Vasco de Quiroga 15, Tlalpán, CP 14080, Mexico City, Mexico; Tecnológico de Monterrey, Escuela de Medicina y Ciencias de la Salud, Calle del puente 222, Ejidos de Huipulco, Tlalpán, 14380, Mexico City, Mexico. Electronic address:

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http://dx.doi.org/10.1016/j.atherosclerosis.2018.08.027DOI Listing
October 2018

Paradoxical coronary artery disease in humans with hyperalphalipoproteinemia is associated with distinct differences in the high-density lipoprotein phosphosphingolipidome.

J Clin Lipidol 2017 Sep - Oct;11(5):1192-1200.e3. Epub 2017 Jul 8.

Division of Translational Medicine and Human Genetics, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jacl.2017.06.018DOI Listing
May 2018

Impact of Lipoproteins on Atherobiology: Emerging Insights.

Cardiol Clin 2018 May;36(2):193-201

National Institute for Health and Medical Research (INSERM) and University of Pierre and Marie Curie - Paris 6, Pitié-Salpêtrière University Hospital, 91 Boulevard de l'Hôpital, Paris 75013, France. Electronic address:

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http://dx.doi.org/10.1016/j.ccl.2017.10.001DOI Listing
May 2018

HDL-Targeting Therapeutics: Past, Present and Future.

Curr Pharm Des 2017 ;23(8):1207-1215

INSERM UMR_S 1166, Faculte de Medecine Pitie-Salpetriere, Bld de L'Hopital 91, 75013 Paris. France.

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http://www.eurekaselect.com/openurl/content.php?genre=articl
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http://dx.doi.org/10.2174/1381612822666161027153140DOI Listing
April 2018

Intestinal lymphatic HDL miR-223 and ApoA-I are reduced during insulin resistance and restored with niacin.

FASEB J 2018 03 3;32(3):1602-1612. Epub 2018 Jan 3.

Metabolic and Cardiovascular Diseases Laboratory, Group on the Molecular Cell Biology of Lipids.

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http://dx.doi.org/10.1096/fj.201600298RRDOI Listing
March 2018

Small dense HDLs display potent vasorelaxing activity, reflecting their elevated content of sphingosine-1-phosphate.

J Lipid Res 2018 01 17;59(1):25-34. Epub 2017 Nov 17.

National Institute for Health and Medical Research (INSERM), UMR-S 1166 ICAN, University of Pierre and Marie Curie-Paris 6, and AP-HP, Groupe Hospitalier Pitié-Salpétrière, Paris, France

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http://dx.doi.org/10.1194/jlr.M076927DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5748494PMC
January 2018

Antioxidative activity of high-density lipoprotein (HDL): Mechanistic insights into potential clinical benefit.

BBA Clin 2017 Dec 19;8:66-77. Epub 2017 Aug 19.

National Institute for Health and Medical Research (INSERM), UMR ICAN 1166, University of Pierre and Marie Curie-Paris 6, AP-HP, Groupe hospitalier Pitié-Salpétrière, Paris F-75013, France.

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http://dx.doi.org/10.1016/j.bbacli.2017.07.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5597817PMC
December 2017

Structure-function relationships in reconstituted HDL: Focus on antioxidative activity and cholesterol efflux capacity.

Biochim Biophys Acta Mol Cell Biol Lipids 2017 Sep 18;1862(9):890-900. Epub 2017 May 18.

National Institute for Health and Medical Research (INSERM), INSERM UMR 1166 ICAN, Paris, France; University of Pierre and Marie Curie-Paris 6, Paris, France; AP-HP, Groupe Hospitalier Pitié Salpétrière, Paris, France. Electronic address:

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http://dx.doi.org/10.1016/j.bbalip.2017.05.010DOI Listing
September 2017

Oxidative stress, HDL functionality and effects of intravenous iron administration in women with iron deficiency anemia.

Clin Nutr 2017 04 13;36(2):552-558. Epub 2016 Feb 13.

Laboratory of Lipids and Atherosclerosis, School of Pharmacy and Biochemistry, INFIBIOC, University of Buenos Aires, CONICET, Buenos Aires, Argentina.

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http://dx.doi.org/10.1016/j.clnu.2016.02.003DOI Listing
April 2017

Poor glycemic control in type 2 diabetes enhances functional and compositional alterations of small, dense HDL3c.

Biochim Biophys Acta Mol Cell Biol Lipids 2017 Feb 2;1862(2):188-195. Epub 2016 Nov 2.

INSERM UMR_S 1166, Faculte de Medecine Pitie-Salpetriere, 91 Bld de l'Hopital, 75013 Paris, France; University of Pierre and Marie Curie - Paris 6, Paris, France. Electronic address:

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http://dx.doi.org/10.1016/j.bbalip.2016.10.014DOI Listing
February 2017

Small, dense high-density lipoprotein 3 particles exhibit defective antioxidative and anti-inflammatory function in familial hypercholesterolemia: Partial correction by low-density lipoprotein apheresis.

J Clin Lipidol 2016 Jan-Feb;10(1):124-33. Epub 2015 Oct 17.

Université Pierre et Marie Curie-Paris 6, Paris, France; AP-HP, Groupe hospitalier Pitié-Salpétrière, Paris, France; National Institute for Health and Medical Research (INSERM), Paris, France. Electronic address:

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http://dx.doi.org/10.1016/j.jacl.2015.10.006DOI Listing
November 2016

Enhanced HDL Functionality in Small HDL Species Produced Upon Remodeling of HDL by Reconstituted HDL, CSL112: Effects on Cholesterol Efflux, Anti-Inflammatory and Antioxidative Activity.

Circ Res 2016 Sep 19;119(6):751-63. Epub 2016 Jul 19.

From the CSL Behring AG, Berne, Switzerland (S.A.D., A.V.N., P.S., M.O.S.); National Institute for Health and Medical Research (INSERM), UMR-ICAN 1166, Paris, France (A.M.O.C., M.J.C., A.K.); University of Pierre and Marie Curie - Paris 6, France (A.M.O.C., M.J.C., A.K.); Pitié - Salpétrière University Hospital; ICAN, Paris, France (A.M.O.C., M.J.C., A.K.); CSL Limited, Parkville, VIC, Australia (A.G.); AP-HP, HUPS Hôpital de Bicêtre, Le Kremlin-Bicêtre, France (P.T.); and CSL Behring, King of Prussia, PA (S.D.W.).

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http://dx.doi.org/10.1161/CIRCRESAHA.116.308685DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5006797PMC
September 2016

Phosphatidylserine in atherosclerosis.

Curr Opin Lipidol 2016 08;27(4):414-20

National Institute for Health and Medical Research (INSERM); University of Pierre and Marie Curie; AP-HP, Groupe Hospitalier Pitié-Salpétrière, Paris, France.

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http://dx.doi.org/10.1097/MOL.0000000000000298DOI Listing
August 2016

Associations between disease activity, markers of HDL functionality and arterial stiffness in patients with rheumatoid arthritis.

Atherosclerosis 2016 08 11;251:438-444. Epub 2016 Jun 11.

Laboratory of Lipids and Lipoproteins, School of Pharmacy and Biochemistry, INFIBIOC, University of Buenos Aires, CONICET, Buenos Aires, Argentina.

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http://dx.doi.org/10.1016/j.atherosclerosis.2016.06.009DOI Listing
August 2016

Proteomic and lipidomic analyses of paraoxonase defined high density lipoprotein particles: Association of paraoxonase with the anti-coagulant, protein S.

Proteomics Clin Appl 2016 Mar 8;10(3):230-8. Epub 2015 Dec 8.

Clinical Diabetes Unit, Department of Medical Specialities, Medical Faculty, University of Geneva, Geneva, Switzerland.

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http://dx.doi.org/10.1002/prca.201500062DOI Listing
March 2016

Identifying new Risk Markers and Potential Targets: The Value of the Proteome.

Authors:
Anatol Kontush

Cardiovasc Drugs Ther 2016 Feb;30(1):13-8

National Institute for Health and Medical Research (INSERM), Research Unit 1166 ICAN, University of Pierre and Marie Curie - Paris 6, Pitié - Salpétrière University Hospital, 91, boulevard de l'Hôpital, 75013, Paris, France.

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http://dx.doi.org/10.1007/s10557-016-6656-3DOI Listing
February 2016

HDL particle subpopulations: Focus on biological function.

Biofactors 2015 Mar-Apr;41(2):67-77. Epub 2015 Mar 23.

National Institute for Health and Medical Research (INSERM), UMR-ICAN 1166, Université Pierre et Marie Curie-Paris 6, AP-HP, Pitié-Salpétrière University Hospital, ICAN, Paris, France; Heart Institute-InCor, University of Sao Paulo Medical School Hospital, Sao Paulo, Brazil; Hospital Israelita Albert Einstein, Sao Paulo, Brazil.

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http://dx.doi.org/10.1002/biof.1202DOI Listing
January 2016

Can phosphatidylserine enhance atheroprotective activities of high-density lipoprotein?

Biochimie 2016 Jan 30;120:81-6. Epub 2015 Jun 30.

UMR INSERM-UPMC 1166 ICAN, Pavillon Benjamin Delessert, Hôpital de la Pitié, 83 Boulevard de l'Hôpital, 75651 Paris Cedex 13, France. Electronic address:

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http://dx.doi.org/10.1016/j.biochi.2015.06.022DOI Listing
January 2016

Dysfunctional HDL and atherosclerotic cardiovascular disease.

Nat Rev Cardiol 2016 Jan 1;13(1):48-60. Epub 2015 Sep 1.

Pharmacology &Nutritional Sciences and Saha Cardiovascular Research Center, University of Kentucky College of Medicine, Lexington, KY, USA.

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http://dx.doi.org/10.1038/nrcardio.2015.124DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6245940PMC
January 2016

Therapeutic applications of reconstituted HDL: When structure meets function.

Pharmacol Ther 2016 Jan 10;157:28-42. Epub 2015 Nov 10.

UMR INSERM-UPMC 1166 ICAN, Pavillon Benjamin Delessert, Hôpital de la Pitié, 83 boulevard de l'Hôpital, 75651 Paris Cedex 13, France. Electronic address:

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http://dx.doi.org/10.1016/j.pharmthera.2015.10.010DOI Listing
January 2016

HDL particle number and size as predictors of cardiovascular disease.

Authors:
Anatol Kontush

Front Pharmacol 2015 5;6:218. Epub 2015 Oct 5.

National Institute for Health and Medical Research (INSERM), UMR-ICAN 1166, Pitié-Salpétrière University Hospital, University of Pierre and Marie Curie -Paris 6 Paris, France.

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http://dx.doi.org/10.3389/fphar.2015.00218DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4593254PMC
October 2015

Defective functionality of small, dense HDL3 subpopulations in ST segment elevation myocardial infarction: Relevance of enrichment in lysophosphatidylcholine, phosphatidic acid and serum amyloid A.

Biochim Biophys Acta 2015 Sep 30;1851(9):1254-61. Epub 2015 May 30.

National Institute of Health and Medical Research (INSERM), UMR-ICAN 1166, University of Pierre and Marie Curie - Paris 6; Pitié-Salpétrière University Hospital, ICAN, Paris, France. Electronic address:

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http://dx.doi.org/10.1016/j.bbalip.2015.05.007DOI Listing
September 2015

Circulating phospholipid profiling identifies portal contribution to NASH signature in obesity.

J Hepatol 2015 Apr 8;62(4):905-12. Epub 2014 Nov 8.

Sorbonne Universités, UPMC Université Paris 06, UMR_S 1166 I, ICAN, Nutriomics Team, F-75005 Paris, France; INSERM, UMR_S U1166, Nutriomics Team, F-75013 Paris, France; Institute of Cardiometabolism and Nutrition, ICAN, AP-HP, Pitié-Salpêtrière Hospital, F-75013 Paris, France. Electronic address:

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http://dx.doi.org/10.1016/j.jhep.2014.11.002DOI Listing
April 2015

Structure of HDL: particle subclasses and molecular components.

Handb Exp Pharmacol 2015 ;224:3-51

National Institute for Health and Medical Research (INSERM), UMR-ICAN 1166, Paris, France,

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http://dx.doi.org/10.1007/978-3-319-09665-0_1DOI Listing
April 2015

Functionality of HDL: antioxidation and detoxifying effects.

Handb Exp Pharmacol 2015 ;224:207-28

Occupational and Environmental Medicine, Heart Medical Centre, County Council of Ostergotland, Linkoping University, SE-58185, Linkoping, Sweden,

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http://dx.doi.org/10.1007/978-3-319-09665-0_5DOI Listing
April 2015

HDL particle size is a critical determinant of ABCA1-mediated macrophage cellular cholesterol export.

Circ Res 2015 Mar 14;116(7):1133-42. Epub 2015 Jan 14.

From the Centre for Vascular Research, University of New South Wales, Sydney, New South Wales, Australia (X.-M.D., M.-J.K., L.H., S.P.C., C.M.Q., K.-A.R); INSERM, UMR_1166, Research Institute of Cardiovascular Disease, Metabolism and Nutrition, Pitié-Salpétrière University Hospital, Paris, France (W.L.G., M.J.C., A.K.); Université Pierre et Marie Curie-Paris 6, Paris, France (W.L.G., M.J.C., A.K.); Division of Biopharmaceutics, Leiden Academic Centre for Drug Research, Leiden, The Netherlands (M.V.E.); Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA (L.K.C.); Department of Clinical Biochemistry, Royal Perth Hospital, Perth, Western Australia, Australia (J.R.B.); School of Medicine and Pharmacology, University of Western Australia, Crawley, Western Australia, Australia (J.R.B.); Atherosclerosis Laboratory, ANZAC Research Institute, University of Sydney, Sydney, New South Wales, Australia (M.K., L.K., W.J.); and Department of Cardiology, Concord Hospital, Sydney, New South Wales, Australia (L.K.).

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http://dx.doi.org/10.1161/CIRCRESAHA.116.305485DOI Listing
March 2015

Defective functionality of HDL particles in familial apoA-I deficiency: relevance of alterations in HDL lipidome and proteome.

J Lipid Res 2014 Dec 23;55(12):2509-20. Epub 2014 Oct 23.

National Institute for Health and Medical Research (INSERM), UMR-ICAN 1166, University of Pierre and Marie Curie - Paris 6, Pitié - Salpétrière University Hospital, ICAN, Paris, France.

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http://www.jlr.org/content/55/12/2509.full.pdf
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http://www.jlr.org/cgi/doi/10.1194/jlr.M051631
Publisher Site
http://dx.doi.org/10.1194/jlr.M051631DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4242444PMC
December 2014

Altered lipidome and antioxidative activity of small, dense HDL in normolipidemic rheumatoid arthritis: relevance of inflammation.

Atherosclerosis 2014 Dec 18;237(2):652-60. Epub 2014 Oct 18.

National Institute for Health and Medical Research (INSERM), UMR-ICAN 1166, Paris F-75013, France; Université Pierre et Marie Curie-Paris 6, Paris F-75013 France; AP-HP, Groupe Hospitalier Pitié-Salpétrière, Paris F-75013, France. Electronic address:

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http://dx.doi.org/10.1016/j.atherosclerosis.2014.09.034DOI Listing
December 2014

High-density lipoproteins: a consensus statement from the National Lipid Association.

J Clin Lipidol 2013 Sep-Oct;7(5):484-525. Epub 2013 Aug 11.

CGH Medical Center, Sterling, IL 61081, USA; University of Illinois School of Medicine, Peoria, IL, USA; Michigan State University College of Osteopathic Medicine, East Lansing, MI, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jacl.2013.08.001DOI Listing
October 2014

HDL-mediated mechanisms of protection in cardiovascular disease.

Authors:
Anatol Kontush

Cardiovasc Res 2014 Aug 15;103(3):341-9. Epub 2014 Jun 15.

National Institute for Health and Medical Research (INSERM), UMR-ICAN 1166, University of Pierre and Marie Curie - Paris 6, Pitié - Salpétrière University Hospital, ICAN, 75651 Paris Cedex 13, France

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http://dx.doi.org/10.1093/cvr/cvu147DOI Listing
August 2014

HDL-targeted therapies: progress, failures and future.

Nat Rev Drug Discov 2014 Jun 23;13(6):445-64. Epub 2014 May 23.

Magdalen College, University of Oxford, Oxford OX1 4AU, UK.

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http://dx.doi.org/10.1038/nrd4279DOI Listing
June 2014

Small, dense high-density lipoprotein-3 particles are enriched in negatively charged phospholipids: relevance to cellular cholesterol efflux, antioxidative, antithrombotic, anti-inflammatory, and antiapoptotic functionalities.

Arterioscler Thromb Vasc Biol 2013 Dec 3;33(12):2715-23. Epub 2013 Oct 3.

From the National Institute for Health and Medical Research (INSERM), Dyslipidemia, Inflammation and Atherosclerosis Research Unit (UMR 939), Paris, France (L.C., M.L., F.R., W.L.G., M.J.C., A.K.); Université Pierre et Marie Curie - Paris 6, Paris, France (L.C., M.L., F.R., W.L.G., M.J.C., A.K.); AP-HP, Groupe Hospitalier Pitié Salpétrière, Paris, France (L.C., M.L., F.R., W.L.G., M.J.C., A.K.); ICAN, Paris, France (L.C., M.L., F.R., W.L.G., M.J.C., A.K.); Heart Institute-InCor, University of Sao Paulo Medical School Hospital, Sao Paulo, Brazil (F.R.); INSERM UMR- 1048, Toulouse, France (A.N.-S., R.S.); Faculty of Medicine, Department of Biochemistry, University of Toulouse, Toulouse, France (A.N.-S., R.S.); and INSERM UMR- 1060, Université de Lyon, Cardiovasculaire, Métabolisme, Diabétologie, et Nutrition (CarMeN), INSA-Lyon, IMBL, Lyon, France (C.C., M.L.).

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http://dx.doi.org/10.1161/ATVBAHA.113.301468DOI Listing
December 2013

Unraveling the complexities of the HDL lipidome.

J Lipid Res 2013 Nov 30;54(11):2950-63. Epub 2013 Mar 30.

Dyslipidemia, Inflammation and Atherosclerosis Research Unit (UMR 939), National Institute for Health and Medical Research (INSERM), Paris, France; Université Pierre et Marie Curie 6, Paris, France; Groupe Hospitalier Pitié Salpétrière, AP-HP, Paris, France; Institute of Cardiometabolism and Nutrition (ICAN), Paris, France.

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http://dx.doi.org/10.1194/jlr.R036095DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3793600PMC
November 2013

Dyslipidemia, but not hyperglycemia and insulin resistance, is associated with marked alterations in the HDL lipidome in type 2 diabetic subjects in the DIWA cohort: impact on small HDL particles.

Biochim Biophys Acta 2013 Nov 27;1831(11):1609-17. Epub 2013 Jul 27.

Sahlgrenska Center for Cardiovascular and Metabolic Research/Wallenberg Laboratory, Göteborg University, Göteborg, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.bbalip.2013.07.009DOI Listing
November 2013

Translation of high-density lipoprotein function into clinical practice: current prospects and future challenges.

Circulation 2013 Sep;128(11):1256-67

Cardiovascular Institute, Icahn School of Medicine at Mount Sinai, New York, NY (R.S.R.); Cardiovascular Research Institute, MedStar Research Institute, Washington Hospital Center, Washington, DC (H.B.B.); Atherosclerosis Research Unit, Division of Cardiology, David Geffen School of Medicine at UCLA, Los Angeles, CA (B.A.); Centre for Vascular Research at the University of New South Wales, Sydney, Australia (P.B.); Dyslipidemia, Atherosclerosis and Inflammation Research Unit 939, National Institute for Health and Medical Research, University of Pierre and Marie Curie - Paris 6, Pitie-Salpetriere Hospital, Paris, France (M.J.C., A.K.) Division of Metabolism, Endocrinology, and Nutrition, University of Washington, Seattle (J.W.H.); Department of Medicine, Columbia University, New York, NY (A.R.T.); and Internal Medicine and Saha Cardiovascular Research Center, University of Kentucky College of Medicine, Lexington (N.R.W.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.113.000962DOI Listing
September 2013

Effect of one-year vitamin C- and E-supplementation on cerebrospinal fluid oxidation parameters and clinical course in Alzheimer's disease.

Neurochem Res 2012 Dec 10;37(12):2706-14. Epub 2012 Aug 10.

Department of Psychiatry and Psychotherapy, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany.

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http://dx.doi.org/10.1007/s11064-012-0860-8DOI Listing
December 2012

Is a cardioprotective action of alcohol a myth?

Curr Opin Cardiol 2012 Sep;27(5):550-5

Service d'Endocrinologie-Métabolisme, AP-HP, France.

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http://dx.doi.org/10.1097/HCO.0b013e328356dc30DOI Listing
September 2012

Biological activities of HDL subpopulations and their relevance to cardiovascular disease.

Trends Mol Med 2011 Oct 10;17(10):594-603. Epub 2011 Aug 10.

National Institute for Health and Medical Research (INSERM), Dyslipidemia, Inflammation and Atherosclerosis Research Unit (UMR 939), Paris F-75013, France.

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http://dx.doi.org/10.1016/j.molmed.2011.05.013DOI Listing
October 2011

Apolipoprotein A-I structural organization in high-density lipoproteins isolated from human plasma.

Nat Struct Mol Biol 2011 Apr 13;18(4):416-22. Epub 2011 Mar 13.

Department of Pathology and Laboratory Medicine, University of Cincinnati, Cincinnati, Ohio, USA.

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http://dx.doi.org/10.1038/nsmb.2028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3079355PMC
April 2011

Antiatherogenic function of HDL particle subpopulations: focus on antioxidative activities.

Curr Opin Lipidol 2010 Aug;21(4):312-8

National Institute for Health and Medical Research (INSERM), Dyslipidemia, Inflammation and Atherosclerosis Research Unit (UMR 939), Paris, France.

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http://dx.doi.org/10.1097/MOL.0b013e32833bcdc1DOI Listing
August 2010

Plasma bilirubin and gamma-glutamyltransferase activity are inversely related in dyslipidemic patients with metabolic syndrome: relevance to oxidative stress.

Atherosclerosis 2010 Jun 29;210(2):607-13. Epub 2009 Dec 29.

Unités de Prévention Cardiovasculaire, Service d'Endocrinologie-Métabolisme, Assistance Publique/Hopitaux de Paris, Groupe Hospitalier Pitié-Salpétrière-Université Pierre et Marie Curie, France.

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http://dx.doi.org/10.1016/j.atherosclerosis.2009.12.026DOI Listing
June 2010

Lipidomics as a tool for the study of lipoprotein metabolism.

Curr Atheroscler Rep 2010 May;12(3):194-201

Université Pierre et Marie Curie-Paris 6, Paris, 75013, France.

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http://dx.doi.org/10.1007/s11883-010-0100-0DOI Listing
May 2010

Small, dense HDL 3 particles attenuate apoptosis in endothelial cells: pivotal role of apolipoprotein A-I.

J Cell Mol Med 2010 Mar 20;14(3):608-20. Epub 2009 Feb 20.

Dyslipoproteinemia and Atherosclerosis Research Unit (UMR939), National Institute for Health and Medical Research (INSERM), Hôpital de la Pitié, Paris, France.

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http://dx.doi.org/10.1111/j.1582-4934.2009.00713.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3823460PMC
March 2010

Cholesteryl ester transfer protein: at the heart of the action of lipid-modulating therapy with statins, fibrates, niacin, and cholesteryl ester transfer protein inhibitors.

Eur Heart J 2010 Jan 12;31(2):149-64. Epub 2009 Oct 12.

INSERM, UMR S939, Dyslipidemia, Inflammation and Atherosclerosis Research Unit, University Pierre and Marie Curie-Paris 6, Pavillon Benjamin Delessert, Hôpital de la Pitié, 83 Boulevard de l'Hôpital, Paris Cedex 13, France.

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http://dx.doi.org/10.1093/eurheartj/ehp399DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2806550PMC
January 2010

HDL3-mediated inactivation of LDL-associated phospholipid hydroperoxides is determined by the redox status of apolipoprotein A-I and HDL particle surface lipid rigidity: relevance to inflammation and atherogenesis.

Arterioscler Thromb Vasc Biol 2009 Dec 17;29(12):2169-75. Epub 2009 Sep 17.

Dyslipidemia and Atherosclerosis Research Unit (UMRS 939), National Institute for Health and Medical Research (INSERM), Hôpital de Pitié; UPMC Paris 6, University Paris Descartes, France.

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https://www.ahajournals.org/doi/10.1161/ATVBAHA.109.194555
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December 2009

Distinct HDL subclasses present similar intrinsic susceptibility to oxidation by HOCl.

Arch Biochem Biophys 2009 Jul 21;487(1):28-35. Epub 2009 May 21.

Université Pierre et Marie Curie-Paris 6, UMR S939 "Dyslipydemia, Inflammation and Atherosclerosis in Metabolic Diseases", F-75013 Paris, France.

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http://dx.doi.org/10.1016/j.abb.2009.05.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3070237PMC
July 2009

Proteomic analysis of defined HDL subpopulations reveals particle-specific protein clusters: relevance to antioxidative function.

Arterioscler Thromb Vasc Biol 2009 Jun 26;29(6):870-6. Epub 2009 Mar 26.

Department of Pathobiology and Laboratory Medicine, University of Cincinnati, Cincinnati, OH 45221, USA.

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https://www.ahajournals.org/doi/10.1161/ATVBAHA.109.186031
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2845307PMC
June 2009

Despite antiatherogenic metabolic characteristics, SCD1-deficient mice have increased inflammation and atherosclerosis.

Arterioscler Thromb Vasc Biol 2009 Mar 18;29(3):341-7. Epub 2008 Dec 18.

Centre for Molecular Medicine and Therapeutics, Department of Medical Genetics, University of British Columbia, and Child & Family Research Institute, 980 West 28th Avenue, Vancouver, BC, Canada V5Z 4H4.

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https://www.ahajournals.org/doi/10.1161/ATVBAHA.108.181099
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2873333PMC
March 2009

HDL: close to our memories?

Arterioscler Thromb Vasc Biol 2008 Aug;28(8):1418-20

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http://dx.doi.org/10.1161/ATVBAHA.108.169714DOI Listing
August 2008

Structure of apolipoprotein A-I in spherical high density lipoproteins of different sizes.

Proc Natl Acad Sci U S A 2008 Aug 21;105(34):12176-81. Epub 2008 Aug 21.

Department of Pathology and Laboratory Medicine, University of Cincinnati, Cincinnati, OH 45237, USA.

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http://dx.doi.org/10.1073/pnas.0803626105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2527885PMC
August 2008

Spotlight on HDL-raising therapies: insights from the torcetrapib trials.

Nat Clin Pract Cardiovasc Med 2008 Jun 22;5(6):329-36. Epub 2008 Apr 22.

INSERM, Unité 551, Pavillon Benjamin Delessert, Hôpital de la Pitié, 83 Boulevard de l'Hôpital, 75651 Paris Cedex 13, France.

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http://dx.doi.org/10.1038/ncpcardio1191DOI Listing
June 2008

An update on using vitamin E in Alzheimer's disease.

Expert Opin Drug Discov 2008 Feb;3(2):261-71

INSERM Unité 551, Pavillon Benjamin Delessert, Hôpital de la Pitié, 83 boulevard de l'Hôpital, 75651 Paris Cedex 13, France +33 1 42177976 ; +33 1 45828198 ;

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http://dx.doi.org/10.1517/17460441.3.2.261DOI Listing
February 2008

Why is HDL functionally deficient in type 2 diabetes?

Curr Diab Rep 2008 Feb;8(1):51-9

INSERM Unité 551, Pavillon Benjamin Delessert, Hôpital de Pitié, 83 boulevard de l'Hôpital, 75651 Paris Cedex 13, France.

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February 2008

Alterations in lipoprotein defense against oxidative stress in metabolic syndrome.

Curr Atheroscler Rep 2006 Nov;8(6):501-9

Service d'Endocrinologie-Métabolisme, Pavillon Benjamin Delessert, Hôpital de la Pitié, 83 Boulevard de l'Hôpital, 75651 Paris Cedex 13, France.

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November 2006

Functionally defective high-density lipoprotein: a new therapeutic target at the crossroads of dyslipidemia, inflammation, and atherosclerosis.

Pharmacol Rev 2006 Sep;58(3):342-74

Dyslipoproteinemia and Atherosclerosis Research Unit, National Institute for Health and Medical Research, Hôpital de la Pitié, 83 boulevard de l'Hôpital, 75651 Paris Cedex 13, France.

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http://pharmrev.aspetjournals.org/cgi/doi/10.1124/pr.58.3.1
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September 2006

Antiatherogenic small, dense HDL--guardian angel of the arterial wall?

Nat Clin Pract Cardiovasc Med 2006 Mar;3(3):144-53

National Institute for Health and Medical Research (INSERM), Unité 551, Hôpital de la Pitié, Paris, France.

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http://dx.doi.org/10.1038/ncpcardio0500DOI Listing
March 2006

Amyloid-beta: acute-phase apolipoprotein with metal-binding activity.

Authors:
Anatol Kontush

J Alzheimers Dis 2005 Nov;8(2):129-37; discussion 209-15

INSERM Unité 551, Hôpital de la Pitié, Pavillon Benjamin Delessert, 83, Bd de l'Hôpital, 75651 Paris Cedex 13, France.

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November 2005

A normotriglyceridemic, low HDL-cholesterol phenotype is characterised by elevated oxidative stress and HDL particles with attenuated antioxidative activity.

Atherosclerosis 2005 Oct 28;182(2):277-85. Epub 2005 Mar 28.

Dyslipoproteinemia and Atherosclerosis Research Unit (U.551), National Institute for Health and Medical Research (INSERM), Hôpital de la Pitié, 83 boulevard de l'Hôpital, 75651 Paris Cedex 13, France.

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http://dx.doi.org/10.1016/j.atherosclerosis.2005.03.001DOI Listing
October 2005

Metabolic syndrome is associated with elevated oxidative stress and dysfunctional dense high-density lipoprotein particles displaying impaired antioxidative activity.

J Clin Endocrinol Metab 2004 Oct;89(10):4963-71

Dyslipoproteinemia and Atherosclerosis Research Unit, National Institute for Health and Medical Research, Institut National de la Santé et de la Recherche Médicale, Hôpital de la Pitié, 75013 Paris, France.

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http://dx.doi.org/10.1210/jc.2004-0305DOI Listing
October 2004

Apolipoprotein Abeta: black sheep in a good family.

Authors:
Anatol Kontush

Brain Pathol 2004 Oct;14(4):433-47

INSERM Unité 551, Hôpital de la Pitié, Pavilion Benjamin Delessert, 83, Bd de l'Hôpital, 75651 Paris Cedex 13, France.

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October 2004

Amyloid-beta: phylogenesis of a chameleon.

Brain Res Brain Res Rev 2004 Aug;46(1):118-20

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http://dx.doi.org/10.1016/j.brainresrev.2004.05.001DOI Listing
August 2004

Vitamin E is not deficient in human atherosclerotic plaques.

Arterioscler Thromb Vasc Biol 2004 Jul;24(7):e139-40; author reply e141-2

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http://dx.doi.org/10.1161/01.ATV.0000131259.97572.99DOI Listing
July 2004

High-density lipoprotein as a key component in the prevention of premature atherosclerotic disease in the insulin resistance syndrome.

Semin Vasc Med 2004 May;4(2):215-23

Dyslipoproteinemia and Atherosclerosis Research Unit (U.551), National Institute for Health and Medical Research (INSERM) Pitie-Salpetriere Hospital, Paris, France.

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http://dx.doi.org/10.1055/s-2004-835381DOI Listing
May 2004

Antioxidative activity of HDL particle subspecies is impaired in hyperalphalipoproteinemia: relevance of enzymatic and physicochemical properties.

Arterioscler Thromb Vasc Biol 2004 Mar 22;24(3):526-33. Epub 2004 Jan 22.

Dyslipoproteinemia and Atherosclerosis Research Unit (U.551),National Institute for Health and Medical Research, Hôpital de la Pitié, Paris, France.

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http://dx.doi.org/10.1161/01.ATV.0000118276.87061.00DOI Listing
March 2004

Plasma and CSF markers of oxidative stress are increased in Parkinson's disease and influenced by antiparkinsonian medication.

Neurobiol Dis 2004 Feb;15(1):160-70

Neurological Department, University Clinic Hamburg-Eppendorf, D-20246 Hamburg, Germany.

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February 2004

Small, dense HDL particles exert potent protection of atherogenic LDL against oxidative stress.

Arterioscler Thromb Vasc Biol 2003 Oct 14;23(10):1881-8. Epub 2003 Aug 14.

Dyslipoproteinemia and Atherosclerosis Research Unit (U.551), National Institute for Health and Medical Research (INSERM), Hôpital de la Pitié, Paris, France.

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http://dx.doi.org/10.1161/01.ATV.0000091338.93223.E8DOI Listing
October 2003

Neonatal blood plasma is less susceptible to oxidation than adult plasma owing to its higher content of bilirubin and lower content of oxidizable Fatty acids.

Pediatr Res 2003 May 5;53(5):843-9. Epub 2003 Mar 5.

Klinik für Kinder- und Jugendmedizin, Universitätskrankenhaus Eppendorf, Martinistrabetae 52, 20246 Hamburg, Germany.

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http://dx.doi.org/10.1203/01.PDR.0000057983.95219.0BDOI Listing
May 2003

VLDL-induced triglyceride accumulation in human macrophages is mediated by modulation of LPL lipolytic activity in the absence of change in LPL mass.

Biochim Biophys Acta 2003 Feb;1631(1):51-60

National Institute for Health and Medical Research (INSERM) Unite 551, Hôpital de la Pitié, 83, Boulevard de l'Hôpital, F-75651 Paris Cedex 13, France.

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February 2003

Mildly oxidized LDL particle subspecies are distinct in their capacity to induce apoptosis in endothelial cells: role of lipid hydroperoxides.

FASEB J 2003 Jan 15;17(1):88-90. Epub 2002 Nov 15.

INSERM U.551, Pavillon Benjamin Delessert, Hôpital de la Pitié, 75651 Paris Cedex 13, France.

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http://dx.doi.org/10.1096/fj.02-0293fjeDOI Listing
January 2003

Comparison of the effects of alpha-tocopherol, ubiquinone-10 and probucol at therapeutic doses on atherosclerosis in WHHL rabbits.

Atherosclerosis 2002 Aug;163(2):249-59

HELIOS Klinikum-Berlin, Franz Volhard Clinic at the Max Delbrück Center for Molecular Medicine, Medical Faculty of the Charité, Humboldt University, Wiltbergstr. 50, 13125 Berlin, Germany.

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August 2002

Increased lipid peroxidation in cerebrospinal fluid and plasma from patients with Creutzfeldt-Jakob disease.

Neurobiol Dis 2002 Jul;10(2):150-6

Institute for Medical Biochemistry and Molecular Biology, University Hospital Hamburg-Eppendorf, Hamburg, Germany.

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July 2002

Decreased plasma and cerebrospinal fluid ascorbate levels in patients with septic encephalopathy.

Free Radic Res 2002 Jul;36(7):735-9

Neurological Clinic, University Hospital Hamburg-Eppendorf, Hamburg, Germany. Medical Clinic, University Hospital Hamburg-Eppendorf, Hamburg, Germany.

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July 2002

Lipid peroxidation in neurodegeneration: new insights into Alzheimer's disease.

Curr Opin Lipidol 2002 Jun;13(3):289-94

Department of Molecular Cell Biology, Institute for Medical Biochemistry and Molecular Biology, University Hospital Hamburg-Eppendorf, Germany.

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June 2002