Anat Erdreich-Epstein

Anat Erdreich-Epstein

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Anat Erdreich-Epstein

Anat Erdreich-Epstein

Publications by authors named "Anat Erdreich-Epstein"

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42Publications

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Continuous and bolus intraventricular topotecan prolong survival in a mouse model of leptomeningeal medulloblastoma.

PLoS One 2019 4;14(1):e0206394. Epub 2019 Jan 4.

Department of Pathology, Children's Hospital Los Angeles and Keck School of Medicine, University of Southern California, Los Angeles, California, United states of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0206394PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6319703PMC
September 2019

GRK2 promotes growth of medulloblastoma cells and protects them from chemotherapy-induced apoptosis.

Sci Rep 2019 Sep 25;9(1):13902. Epub 2019 Sep 25.

Department of Pediatrics, Division of Hematology, Oncology and Blood and Marrow Transplantation, The Saban Research Institute at Children's Hospital Los Angeles and Keck School of Medicine and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California, USA.

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http://dx.doi.org/10.1038/s41598-019-50157-5DOI Listing
September 2019

Rare Pediatric Invasive Gliofibroma Has BRAFV600E Mutation and Transiently Responds to Targeted Therapy Before Progressive Clonal Evolution.

JCO Precis Oncol 2019 27;3. Epub 2019 Mar 27.

Division of Hematology, Oncology, and Blood and Marrow Transplant Program, Children's Center for Cancer and Blood Diseases, Department of Pediatrics, Children's Hospital Los Angeles.

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http://dx.doi.org/10.1200/PO.18.00138DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6555144PMC
March 2019

BarTeL, a Genetically Versatile, Bioluminescent and Granule Neuron Precursor-Targeted Mouse Model for Medulloblastoma.

PLoS One 2016 16;11(6):e0156907. Epub 2016 Jun 16.

Department of Radiology, The Saban Research Institute, Children's Hospital Los Angeles, and Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0156907PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4911170PMC
July 2017

PID1 increases chemotherapy-induced apoptosis in medulloblastoma and glioblastoma cells in a manner that involves NFκB.

Sci Rep 2017 04 11;7(1):835. Epub 2017 Apr 11.

Saban Research Institute at Children's Hospital Los Angeles, Division of Hematology, Oncology and Blood & Marrow Transplantation, Department of Pediatrics, Los Angeles, California, 90027, USA.

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http://dx.doi.org/10.1038/s41598-017-00947-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5429784PMC
April 2017

Integrated (epi)-Genomic Analyses Identify Subgroup-Specific Therapeutic Targets in CNS Rhabdoid Tumors.

Authors:
Jonathon Torchia Brian Golbourn Shengrui Feng King Ching Ho Patrick Sin-Chan Alexandre Vasiljevic Joseph D Norman Paul Guilhamon Livia Garzia Natalia R Agamez Mei Lu Tiffany S Chan Daniel Picard Pasqualino de Antonellis Dong-Anh Khuong-Quang Aline C Planello Constanze Zeller Dalia Barsyte-Lovejoy Lucie Lafay-Cousin Louis Letourneau Mathieu Bourgey Man Yu Deena M A Gendoo Misko Dzamba Mark Barszczyk Tiago Medina Alexandra N Riemenschneider A Sorana Morrissy Young-Shin Ra Vijay Ramaswamy Marc Remke Christopher P Dunham Stephen Yip Ho-Keung Ng Jian-Qiang Lu Vivek Mehta Steffen Albrecht Jose Pimentel Jennifer A Chan Gino R Somers Claudia C Faria Lucia Roque Maryam Fouladi Lindsey M Hoffman Andrew S Moore Yin Wang Seung Ah Choi Jordan R Hansford Daniel Catchpoole Diane K Birks Nicholas K Foreman Doug Strother Almos Klekner Laszló Bognár Miklós Garami Péter Hauser Tibor Hortobágyi Beverly Wilson Juliette Hukin Anne-Sophie Carret Timothy E Van Meter Eugene I Hwang Amar Gajjar Shih-Hwa Chiou Hideo Nakamura Helen Toledano Iris Fried Daniel Fults Takafumi Wataya Chris Fryer David D Eisenstat Katrin Scheinemann Adam J Fleming Donna L Johnston Jean Michaud Shayna Zelcer Robert Hammond Samina Afzal David A Ramsay Nongnuch Sirachainan Suradej Hongeng Noppadol Larbcharoensub Richard G Grundy Rishi R Lulla Jason R Fangusaro Harriet Druker Ute Bartels Ronald Grant David Malkin C Jane McGlade Theodore Nicolaides Tarik Tihan Joanna Phillips Jacek Majewski Alexandre Montpetit Guillaume Bourque Gary D Bader Alyssa T Reddy G Yancey Gillespie Monika Warmuth-Metz Stefan Rutkowski Uri Tabori Mathieu Lupien Michael Brudno Ulrich Schüller Torsten Pietsch Alexander R Judkins Cynthia E Hawkins Eric Bouffet Seung-Ki Kim Peter B Dirks Michael D Taylor Anat Erdreich-Epstein Cheryl H Arrowsmith Daniel D De Carvalho James T Rutka Nada Jabado Annie Huang

Cancer Cell 2016 Dec;30(6):891-908

Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5G0A4, Canada; Department of Paediatrics, University of Toronto, Toronto, ON M5G0A4, Canada; Division of Hematology/Oncology, Hospital for Sick Children, Toronto, ON M5G1X8, Canada; Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2016.11.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5500911PMC
December 2016

Molecular subgroups of medulloblastoma identification using noninvasive magnetic resonance spectroscopy.

Neuro Oncol 2016 Jan 8;18(1):126-31. Epub 2015 Aug 8.

Children's Hospital Los Angeles and The Saban Research Institute, Los Angeles, California (S.B., A.S.M., R.S., R.J.K., N.J.R., M.V., L.T.H., S.M., A.E-E., F.H.G., A.R.J., M.D.K., G.D., M.D.N., S.A.); Department of Radiology, Keck School of Medicine, University of Southern California, Los Angeles, California (S.B., M.D.N.); Rudi Schulte Research Institute, Santa Barbara, California (S.B., M.D.N.); Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California (R.S.); Department of Pediatrics, Nationwide Children's Hospital, Columbus, Ohio (J.L.F.); Department of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, California (A.E-E., F.H.G., A.R.J., S.A.); Department of Neurosurgery, Keck School of Medicine, University of Southern California, Los Angeles, California (M.D.K.); Department of Pediatrics, Keck School of Medicine, University of Southern California, Los Angeles, California (A.S.M., N.J.R., A.E-E., G.D., S.A.).

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http://dx.doi.org/10.1093/neuonc/nov097DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4677409PMC
January 2016

Disseminated Medulloblastoma in a Child with Germline BRCA2 6174delT Mutation and without Fanconi Anemia.

Front Oncol 2015 27;5:191. Epub 2015 Aug 27.

Division of Hematology-Oncology, Department of Pediatrics, Children's Hospital Los Angeles , Los Angeles, CA , USA ; Department of Pediatrics, Keck School of Medicine, University of Southern California , Los Angeles, CA , USA ; Department of Pathology, Children's Hospital Los Angeles and Keck School of Medicine, University of Southern California , Los Angeles, CA , USA.

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http://dx.doi.org/10.3389/fonc.2015.00191DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4550790PMC
September 2015

Wnt pathway in atypical teratoid rhabdoid tumors.

Neuro Oncol 2015 Apr 21;17(4):526-35. Epub 2014 Sep 21.

Barrow Neurological Institute at Phoenix Children's Hospital, Phoenix, Arizona (M.C., C.N.H., V.O., R.D.B.); Children's Hospital at Westmead, Sydney, Australia (L.Z., D.C.); Duke University, Durham, North Carolina (P.C.); Children's Hospital Los Angeles, Los Angeles, California (A.E.-E.); Children's Hospital Los Angeles and the University of Southern California, Los Angeles, California (J.X., A.E.-E.).

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http://dx.doi.org/10.1093/neuonc/nou229DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4483069PMC
April 2015

Tumor-associated macrophages in SHH subgroup of medulloblastomas.

Clin Cancer Res 2015 Mar 24;21(6):1457-65. Epub 2014 Oct 24.

Children's Hospital Los Angeles and The Saban Research Institute, Los Angeles, California. Department of Pediatrics, Keck School of Medicine of University of Southern California, Los Angeles, California. Department of Pathology, Keck School of Medicine of University of Southern California, Los Angeles, California.

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http://dx.doi.org/10.1158/1078-0432.CCR-14-1144DOI Listing
March 2015

Pediatric brain tumor cell lines.

J Cell Biochem 2015 Feb;116(2):218-24

Division of Hematology, Oncology and Blood & Marrow Transplantation, Department of Pediatrics, Children's Hospital Los Angeles and the Keck School of Medicine, University of Southern California, Los Angeles, California, 90027.

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http://dx.doi.org/10.1002/jcb.24976DOI Listing
February 2015

The chromatin-modifying protein HMGA2 promotes atypical teratoid/rhabdoid cell tumorigenicity.

J Neuropathol Exp Neurol 2015 Feb;74(2):177-85

From the Division of Neuropathology and Sidney Kimmel Comprehensive Cancer Center (HK, MH-C, MFW, CGE, EHR), Division of Pediatric Oncology (EHR), Johns Hopkins University School of Medicine, Bloomberg Children's Hospital, Baltimore, Maryland; Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina (YK, BEW); and Division of Hematology, Oncology, and Blood and Bone Marrow Transplant, Children's Hospital Los Angeles (JX, AE-E); and the University of Southern California (AE-E), Los Angeles, California.

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http://dx.doi.org/10.1097/NEN.0000000000000161DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4695975PMC
February 2015

Novel paracrine modulation of Notch-DLL4 signaling by fibulin-3 promotes angiogenesis in high-grade gliomas.

Cancer Res 2014 Oct 19;74(19):5435-5448. Epub 2014 Aug 19.

Department of Neurosurgery, Brigham and Women's Hospital and Harvard Medical School, The Ohio State University.

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http://dx.doi.org/10.1158/0008-5472.CAN-14-0685DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4184948PMC
October 2014

A retrospective analysis of recurrent intracranial ependymoma.

Pediatr Blood Cancer 2014 Jul 24;61(7):1195-201. Epub 2014 Feb 24.

Division of Hematology/Oncology, Children's Hospital Los Angeles, Los Angeles, California.

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http://dx.doi.org/10.1002/pbc.24996DOI Listing
July 2014

PID1 (NYGGF4), a new growth-inhibitory gene in embryonal brain tumors and gliomas.

Clin Cancer Res 2014 Feb 3;20(4):827-36. Epub 2013 Dec 3.

Authors' Affiliations: Departments of Pediatrics, Pathology, Radiology, and Neurosurgery, at the Saban Research Institute at Children's Hospital Los Angeles, Norris Comprehensive Cancer Center; Departments of Preventive Medicine and Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, California; Division of Pediatric Neurooncology at the German Cancer Research Center DKFZ; and Department of Pediatric Hematology and Oncology, Heidelberg University Hospital, Heidelberg, Germany.

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http://dx.doi.org/10.1158/1078-0432.CCR-13-2053DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3962776PMC
February 2014

A novel tumor-promoting role for nuclear factor IA in glioblastomas is mediated through negative regulation of p53, p21, and PAI1.

Neuro Oncol 2014 Jan 4;16(2):191-203. Epub 2013 Dec 4.

Corresponding author: Hae-Ri Song, MD, New York University School of Medicine, Smilow Research Center 1306, 522 First Avenue, New York, NY 10016.

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https://academic.oup.com/neuro-oncology/article-lookup/doi/1
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http://dx.doi.org/10.1093/neuonc/not167DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3895381PMC
January 2014

c-Abl is an upstream regulator of acid sphingomyelinase in apoptosis induced by inhibition of integrins αvβ3 and αvβ5.

PLoS One 2012 3;7(8):e42291. Epub 2012 Aug 3.

Division of Hematology-Oncology, Department of Pediatrics, Keck School of Medicine, University of Southern California and the Saban Research Institute of Children's Hospital Los Angeles, Los Angeles, California, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0042291PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3411766PMC
January 2013

Heparanase-induced GEF-H1 signaling regulates the cytoskeletal dynamics of brain metastatic breast cancer cells.

Mol Cancer Res 2012 Jun 18;10(6):689-702. Epub 2012 Apr 18.

Department of Pathology & Immunology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA.

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http://dx.doi.org/10.1158/1541-7786.MCR-11-0534DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5524200PMC
June 2012

Novel cell lines established from pediatric brain tumors.

J Neurooncol 2012 Apr 27;107(2):269-80. Epub 2011 Nov 27.

Developmental Therapeutics Program, Division of Hematology-Oncology, USC-CHLA Institute for Pediatric Clinical Research, Children's Hospital Los Angeles, Los Angeles, CA 90027, USA.

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http://link.springer.com/10.1007/s11060-011-0756-5
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http://dx.doi.org/10.1007/s11060-011-0756-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3379550PMC
April 2012

Gliovascular and cytokine interactions modulate brain endothelial barrier in vitro.

J Neuroinflammation 2011 Nov 23;8:162. Epub 2011 Nov 23.

Department of Molecular and Cellular Physiology, School of Graduate Studies, Louisiana State University Health Sciences Center-Shreveport, 1501 Kings Hwy, Shreveport, LA 71130, USA.

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http://dx.doi.org/10.1186/1742-2094-8-162DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3248576PMC
November 2011

Treatment of children with recurrent high grade gliomas with a bevacizumab containing regimen.

J Neurooncol 2011 Jul 1;103(3):673-80. Epub 2010 Nov 1.

Division of Pediatric Hematology Oncology, Childrens Hospital Los Angeles, 4650 Sunset Boulevard, MS# 54, Los Angeles, CA 90027, USA.

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http://dx.doi.org/10.1007/s11060-010-0444-xDOI Listing
July 2011

Novel cancer vaccine based on genes of Salmonella pathogenicity island 2.

Int J Cancer 2010 Jun;126(11):2622-34

Division of Hematology-Oncology, Department of Pediatrics, University of Southern California Keck School of Medicine and The Saban Research Institute of Children's Hospital Los Angeles, Los Angeles, CA, USA.

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http://dx.doi.org/10.1002/ijc.24957DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2993175PMC
June 2010

c-Abl mediates endothelial apoptosis induced by inhibition of integrins alphavbeta3 and alphavbeta5 and by disruption of actin.

Blood 2010 Apr 2;115(13):2709-18. Epub 2010 Feb 2.

Department of Pediatrics, Neil Bogart Memorial Laboratories, Division of Hematology-Oncology, Saban Research Institute at Childrens Hospital Los Angeles, USA.

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http://dx.doi.org/10.1182/blood-2009-05-223776DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2852370PMC
April 2010

Nuclear factor IA is expressed in astrocytomas and is associated with improved survival.

Neuro Oncol 2010 Feb 25;12(2):122-32. Epub 2010 Jan 25.

Departments of Neurosurgery and Neurology, New York University, School of Medicine, 550 First Avenue, New York, NY 10016, USA.

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https://academic.oup.com/neuro-oncology/article-lookup/doi/1
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http://dx.doi.org/10.1093/neuonc/nop044DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2940580PMC
February 2010

Metabolism of orthotopic mouse brain tumor models.

Mol Imaging 2009 Jul-Aug;8(4):199-208

Department of Radiology, Division of Hematology-Oncology, Saban Research Institute at Children's Hospital Los Angeles, USA.

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October 2009

Progress in the treatment of childhood brain tumors: no room for complacency.

Pediatr Hematol Oncol 2007 Jan-Feb;24(1):79-84

Department of Hematology/Oncology, Children's Hospital, Los Angeles, California 90027, USA.

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http://dx.doi.org/10.1080/08880010601001073DOI Listing
December 2006

Androgen inducibility of Fgf8 in Shionogi carcinoma 115 cells correlates with an adjacent t(5;19) translocation.

Genes Chromosomes Cancer 2006 Feb;45(2):169-81

Division of Hematology-Oncology, The Saban Research Institute, Childrens Hospital Los Angeles, California, USA.

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http://dx.doi.org/10.1002/gcc.20280DOI Listing
February 2006

Endothelial apoptosis induced by inhibition of integrins alphavbeta3 and alphavbeta5 involves ceramide metabolic pathways.

Blood 2005 Jun 10;105(11):4353-61. Epub 2005 Feb 10.

Division of Hematology-Oncology, Department of Pediatrics, The Saban Research Institute at Childrens Hospital Los Angeles, 4650 Sunset Blvd, Mailstop No. 57, Los Angeles, CA 90027, USA.

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http://dx.doi.org/10.1182/blood-2004-08-3098DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1895032PMC
June 2005

Bone marrow mesenchymal stem cells provide an alternate pathway of osteoclast activation and bone destruction by cancer cells.

Cancer Res 2005 Feb;65(4):1129-35

Division of Hematology-Oncology, Department of Pediatrics, Keck School of Medicine, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-04-2853DOI Listing
February 2005

Approaches to treatment for extraocular retinoblastoma: Children's Hospital Los Angeles experience.

J Pediatr Hematol Oncol 2004 Jan;26(1):31-4

Department of Pediatrics, University of Southern California Keck School of Medicine and Children's Hospital Los Angeles, Los Angeles California, USA.

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http://dx.doi.org/10.1097/00043426-200401000-00011DOI Listing
January 2004

Induction of intercellular adhesion molecule-1 on human brain endothelial cells by HIV-1 gp120: role of CD4 and chemokine coreceptors.

Lab Invest 2003 Dec;83(12):1787-98

Department of Pediatrics, Johns Hopkins School of Medicine, Baltimore, Maryland 21205, USA.

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December 2003

Placenta growth factor activates monocytes and correlates with sickle cell disease severity.

Blood 2003 Aug 24;102(4):1506-14. Epub 2003 Apr 24.

Division of Hematology-Oncology, Childrens Hospital Los Angeles, CA 90027, USA.

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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2002-11-34
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http://dx.doi.org/10.1182/blood-2002-11-3422DOI Listing
August 2003

Ceramide signaling in fenretinide-induced endothelial cell apoptosis.

J Biol Chem 2002 Dec 17;277(51):49531-7. Epub 2002 Oct 17.

Division of Hematology-Oncology, Department of Pediatrics, Childrens Hospital Los Angeles, Keck School of Medicine, University of Southern California, 4650 Sunset Boulevard, Los Angeles, CA 90027, USA.

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http://dx.doi.org/10.1074/jbc.M209962200DOI Listing
December 2002

Successful multimodality therapy of recurrent multifocal juvenile granulosa cell tumor of the ovary.

J Pediatr Hematol Oncol 2002 Mar-Apr;24(3):229-33

Department of Pediatrics, Childrens Hospital Los Angeles, Keck School of Medicine, California 90027, USA.

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http://dx.doi.org/10.1097/00043426-200203000-00015DOI Listing
May 2002