Dr Anastasia Nijnik, PhD - McGill University - Assistant Prof, Canada Research Chair

Dr Anastasia Nijnik

PhD

McGill University

Assistant Prof, Canada Research Chair

Montreal, Quebec | Canada

Dr Anastasia Nijnik, PhD - McGill University - Assistant Prof, Canada Research Chair

Dr Anastasia Nijnik

PhD

Introduction

Primary Affiliation: McGill University - Montreal, Quebec , Canada

Publications

32Publications

372Reads

3Profile Views

747PubMed Central Citations

USP44 is dispensable for normal hematopoietic stem cell function, lymphocyte development, and B-cell-mediated immune response in a mouse model.

Exp Hematol 2019 04 9;72:1-8. Epub 2019 Jan 9.

Department of Physiology, McGill University, Montreal, QC, Canada; McGill University Centre on Complex Traits, McGill University, Montreal, QC, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.exphem.2019.01.001DOI Listing
April 2019
93 Reads
2.475 Impact Factor

A role for the histone H2A deubiquitinase MYSM1 in maintenance of CD8 T cells.

Immunology 2017 05 20;151(1):110-121. Epub 2017 Feb 20.

Department of Physiology and McGill University Research Centre on Complex Traits, McGill University, Montreal, QC, Canada.

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http://dx.doi.org/10.1111/imm.12710DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5382346PMC
May 2017
4 Reads
1 Citation
3.800 Impact Factor

Mysm1 expression in the bone marrow niche is not essential for hematopoietic maintenance.

Exp Hematol 2017 03 8;47:76-82.e3. Epub 2016 Nov 8.

Department of Physiology, McGill University, Montreal, QC, Canada; McGill University Centre for Complex Traits, McGill University, Montreal, QC, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.exphem.2016.10.013DOI Listing
March 2017
7 Reads
2.480 Impact Factor

MYSM1-dependent checkpoints in B cell lineage differentiation and B cell-mediated immune response.

J Leukoc Biol 2017 03 28;101(3):643-654. Epub 2016 Nov 28.

Department of Physiology, McGill University, Montreal, Quebec, Canada;

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http://dx.doi.org/10.1189/jlb.1AB0415-177RRDOI Listing
March 2017
9 Reads
4.290 Impact Factor

BRPF1 is essential for development of fetal hematopoietic stem cells.

J Clin Invest 2016 09 8;126(9):3247-62. Epub 2016 Aug 8.

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http://dx.doi.org/10.1172/JCI80711DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5004949PMC
September 2016
18 Reads
1 Citation
13.215 Impact Factor

Ubiquitin specific protease 21 is dispensable for normal development, hematopoiesis and lymphocyte differentiation.

PLoS One 2015 13;10(2):e0117304. Epub 2015 Feb 13.

Department of Physiology, McGill University, Montreal, Canada; Complex Traits Group, McGill University, Montreal, Canada.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0117304PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4332479PMC
December 2015
23 Reads
8 Citations
3.234 Impact Factor

Deubiquitinase MYSM1 Is Essential for Normal Fetal Liver Hematopoiesis and for the Maintenance of Hematopoietic Stem Cells in Adult Bone Marrow.

Stem Cells Dev 2015 Aug 30;24(16):1865-77. Epub 2015 Jun 30.

1 Department of Physiology, McGill University , Montreal, Quebec, Canada .

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http://dx.doi.org/10.1089/scd.2015.0058DOI Listing
August 2015
12 Reads
4 Citations
3.730 Impact Factor

p53 mediates loss of hematopoietic stem cell function and lymphopenia in Mysm1 deficiency.

Blood 2015 Apr 20;125(15):2344-8. Epub 2015 Feb 20.

Department of Physiology, Complex Traits Group, and.

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http://dx.doi.org/10.1182/blood-2014-05-574111DOI Listing
April 2015
11 Reads
16 Citations
10.452 Impact Factor

Spinster homolog 2 (spns2) deficiency causes early onset progressive hearing loss.

PLoS Genet 2014 Oct 30;10(10):e1004688. Epub 2014 Oct 30.

Wellcome Trust Sanger Institute, Hinxton, Cambridge, United Kingdom; Wolfson Centre for Age-Related Diseases, King's College London, London, United Kingdom.

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http://dx.doi.org/10.1371/journal.pgen.1004688DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4214598PMC
October 2014
12 Reads
15 Citations

H2A-DUBbing the mammalian epigenome: expanding frontiers for histone H2A deubiquitinating enzymes in cell biology and physiology.

Int J Biochem Cell Biol 2014 May 16;50:161-74. Epub 2014 Mar 16.

Department of Physiology, McGill University, Canada; Complex Traits Group, McGill University, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.biocel.2014.03.004DOI Listing
May 2014
3 Reads
8 Citations
4.050 Impact Factor

Immunomodulatory approaches for prevention and treatment of infectious diseases.

Authors:
Anastasia Nijnik

Curr Opin Microbiol 2013 Oct 17;16(5):590-5. Epub 2013 Jul 17.

Department of Physiology and the Complex Traits Group, McGill University, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.mib.2013.06.011DOI Listing
October 2013
1 Read
6 Citations
5.900 Impact Factor

Manipulation of innate immunity by a bacterial secreted peptide: lantibiotic nisin Z is selectively immunomodulatory.

Innate Immun 2013 Jun 29;19(3):315-27. Epub 2012 Oct 29.

Centre for Microbial Diseases and Immunity Research, University of British Columbia, Vancouver, BC V6T 1Z3, Canada.

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http://dx.doi.org/10.1177/1753425912461456DOI Listing
June 2013
9 Reads
12 Citations
3.271 Impact Factor

Signaling pathways mediating chemokine induction in keratinocytes by cathelicidin LL-37 and flagellin.

J Innate Immun 2012 17;4(4):377-86. Epub 2012 Apr 17.

Centre for Microbial Disease and Immunity Research, Department of Microbiology and Immunology, University of British Columbia, Vancouver, B.C., Canada.

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http://dx.doi.org/10.1159/000335901DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6741628PMC
October 2012
1 Read
9 Citations
4.352 Impact Factor

The role of the Src family kinase Lyn in the immunomodulatory activities of cathelicidin peptide LL-37 on monocytic cells.

J Leukoc Biol 2012 Apr 13;91(4):599-607. Epub 2012 Jan 13.

Department of Microbiology and Immunology, University of British Columbia, Vancouver, Canada.

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http://dx.doi.org/10.1189/jlb.0411191DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3409631PMC
April 2012
12 Reads
4.290 Impact Factor

Modulating immunity as a therapy for bacterial infections.

Nat Rev Microbiol 2012 Mar 16;10(4):243-54. Epub 2012 Mar 16.

Department of Microbiology and Immunology, Centre for Microbial Diseases and Immunity Research, Room 232, 2259 Lower Mall Research Station, University of British Columbia, Vancouver, V6T 1Z4 British Columbia, Canada.

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http://dx.doi.org/10.1038/nrmicro2745DOI Listing
March 2012
14 Reads
86 Citations
23.574 Impact Factor

Cathelicidin peptide LL-37 modulates TREM-1 expression and inflammatory responses to microbial compounds.

Inflammation 2011 Oct;34(5):412-25

Department of Microbiology and Immunology, Centre for Microbial Diseases and Immunity Research, University of British Columbia, 2259 Lower Mall Research Station, Vancouver, V6T 1Z4, Canada.

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http://www.cmdr.ubc.ca/bobh/455.%20Amatngalim%202011.pdf
Web Search
http://search.proquest.com/openview/2b269b0518b7b8d46978ac34
Web Search
http://link.springer.com/10.1007/s10753-010-9248-6
Publisher Site
http://dx.doi.org/10.1007/s10753-010-9248-6DOI Listing
October 2011
2 Reads
10 Citations
1.921 Impact Factor

Synthetic cationic peptide IDR-1002 provides protection against bacterial infections through chemokine induction and enhanced leukocyte recruitment.

J Immunol 2010 Mar 27;184(5):2539-50. Epub 2010 Jan 27.

Department of Microbiology and Immunology, Centre for Microbial Diseases and Immunity Research, University of British Columbia, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.4049/jimmunol.0901813DOI Listing
March 2010
6 Reads
50 Citations
4.922 Impact Factor

Human cathelicidin peptide LL-37 modulates the effects of IFN-gamma on APCs.

J Immunol 2009 Nov 7;183(9):5788-98. Epub 2009 Oct 7.

Centre for Microbial Diseases and Immunity Research, Department of Microbiology and Immunology, University of British Columbia, Vancouver, Canada.

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http://dx.doi.org/10.4049/jimmunol.0901491DOI Listing
November 2009
13 Reads
28 Citations
4.922 Impact Factor

Potential of immunomodulatory host defense peptides as novel anti-infectives.

Trends Biotechnol 2009 Oct 14;27(10):582-90. Epub 2009 Aug 14.

Centre for Microbial Diseases & Immunity Research, Department of Microbiology & Immunology, Room 232, 2259 Lower Mall Research Station, University of British Columbia, Vancouver, BC Canada V6T 1Z4.

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http://dx.doi.org/10.1016/j.tibtech.2009.07.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7114281PMC
October 2009
3 Reads
55 Citations
11.960 Impact Factor

Intracellular receptor for human host defense peptide LL-37 in monocytes.

J Immunol 2009 Aug 15;183(4):2688-96. Epub 2009 Jul 15.

Centre for Microbial Diseases and Immunity Research, University of British Columbia, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.4049/jimmunol.0802586DOI Listing
August 2009
14 Reads
42 Citations
4.922 Impact Factor

Impaired lymphocyte development and antibody class switching and increased malignancy in a murine model of DNA ligase IV syndrome.

J Clin Invest 2009 Jun 18;119(6):1696-705. Epub 2009 May 18.

Henry Wellcome Building of Molecular Physiology, Oxford University, Oxford, United Kingdom.

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http://dx.doi.org/10.1172/JCI32743DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2689126PMC
June 2009
10 Reads
12 Citations
13.215 Impact Factor

The roles of cathelicidin LL-37 in immune defences and novel clinical applications.

Curr Opin Hematol 2009 Jan;16(1):41-7

Centre for Microbial Diseases and Immunity Research, Department of Microbiology and Immunology, 2259 Lower Mall Research Station, University of British Columbia, Vancouver, Canada.

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http://dx.doi.org/10.1097/moh.0b013e32831ac517DOI Listing
January 2009
2 Reads
75 Citations
3.970 Impact Factor

DNA repair is limiting for haematopoietic stem cells during ageing.

Nature 2007 Jun;447(7145):686-90

Henry Wellcome Building for Molecular Physiology, Oxford University, Oxford OX3 9DU, UK.

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http://dx.doi.org/10.1038/nature05875DOI Listing
June 2007
11 Reads
188 Citations
42.351 Impact Factor

Increased positive selection of B1 cells and reduced B cell tolerance to intracellular antigens in c1q-deficient mice.

J Immunol 2007 Mar;178(5):2916-22

Henry Wellcome Building for Molecular Physiology, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom.

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http://dx.doi.org/10.4049/jimmunol.178.5.2916DOI Listing
March 2007
5 Reads
9 Citations
4.922 Impact Factor

Spontaneous B cell hyperactivity in autoimmune-prone MRL mice.

Int Immunol 2006 Jul 30;18(7):1127-37. Epub 2006 May 30.

Henry Wellcome Building of Molecular Physiology, Oxford University, Roosevelt Drive, Oxford, OX3 7BN, UK.

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http://dx.doi.org/10.1093/intimm/dxl047DOI Listing
July 2006
6 Reads
7 Citations
2.540 Impact Factor

B-cell tolerance.

Transplantation 2006 Feb;81(3):308-15

Henry Wellcome Building of Molecular Physiology, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom.

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http://dx.doi.org/10.1097/01.tp.0000203830.79357.39DOI Listing
February 2006
2 Reads
9 Citations
3.830 Impact Factor

Comparing the fine specificity of DNA binding by NF-kappaB p50 and p52 using principal coordinates analysis.

Nucleic Acids Res 2003 Mar;31(5):1497-501

Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC149824PMC
http://dx.doi.org/10.1093/nar/gkg231DOI Listing
March 2003
1 Read
3 Citations
9.112 Impact Factor

Top co-authors

Jessica C Petrov
Jessica C Petrov

McGill University

5
Richard J Cornall
Richard J Cornall

University of Oxford

5
Simon Clare
Simon Clare

Wellcome Trust Sanger Institute

5
Jason Kindrachuk
Jason Kindrachuk

National Institute of Allergy and Infectious Diseases

4
Jelena Pistolic
Jelena Pistolic

University of British Columbia

4
Michael Forster
Michael Forster

Institute of Clinical Molecular Biology

4
Christopher C Goodnow
Christopher C Goodnow

John Curtin School of Medical Research

3
Havard Jenssen
Havard Jenssen

Ruhr University Bochum

3