Anang A Shelat

Anang A Shelat

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Anang A Shelat

Anang A Shelat

Publications by authors named "Anang A Shelat"

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47Publications

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The role of ZA channel water-mediated interactions in the design of bromodomain-selective BET inhibitors.

J Mol Graph Model 2018 05 22;81:197-210. Epub 2018 Mar 22.

Department of Chemical Biology & Therapeutics, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jmgm.2018.03.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6524770PMC
May 2018

Ventromorphins: A New Class of Small Molecule Activators of the Canonical BMP Signaling Pathway.

ACS Chem Biol 2017 09 29;12(9):2436-2447. Epub 2017 Aug 29.

Departments of Hematology, ‡Chemical Biology and Therapeutics, §Tumor Cell Biology, and ∥Computational Biology, St. Jude Children's Research Hospital , Memphis, Tennessee, United States.

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http://dx.doi.org/10.1021/acschembio.7b00527DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5676454PMC
September 2017

Evaluation of artemisinins for the treatment of acute myeloid leukemia.

Cancer Chemother Pharmacol 2016 06 28;77(6):1231-43. Epub 2016 Apr 28.

Division of Pharmaceutics, College of Pharmacy, The Ohio State University, 500 W. 12th St., Columbus, OH, 43210, USA.

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http://dx.doi.org/10.1007/s00280-016-3038-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4918815PMC
June 2016

BRAID: A Unifying Paradigm for the Analysis of Combined Drug Action.

Sci Rep 2016 05 10;6:25523. Epub 2016 May 10.

Departments of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.

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http://dx.doi.org/10.1038/srep25523DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4861905PMC
May 2016

Systematic Screening Identifies Dual PI3K and mTOR Inhibition as a Conserved Therapeutic Vulnerability in Osteosarcoma.

Clin Cancer Res 2015 Jul 10;21(14):3216-29. Epub 2015 Apr 10.

St. Vincent's Institute of Medical Research, Fitzroy, Victoria, Australia. Department of Medicine, St. Vincent's Hospital, University of Melbourne, Fitzroy, Victoria, Australia. ACRF Rational Drug Discovery Centre, St. Vincent's Institute of Medical Research, Fitzroy, Victoria, Australia.

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http://dx.doi.org/10.1158/1078-0432.CCR-14-3026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4506243PMC
July 2015

A high-throughput screen reveals new small-molecule activators and inhibitors of pantothenate kinases.

J Med Chem 2015 Feb 21;58(3):1563-8. Epub 2015 Jan 21.

Department of Chemical Biology and Therapeutics, ‡Department of Infectious Diseases, St. Jude Children's Research Hospital , 262 Danny Thomas Place, Memphis, Tennessee 38105, United States.

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http://dx.doi.org/10.1021/jm501585qDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4357395PMC
February 2015

Development of a cell-based, high-throughput screening assay for ATM kinase inhibitors.

J Biomol Screen 2014 Apr 24;19(4):538-46. Epub 2014 Jan 24.

1Department of Oncology, St. Jude Children's Research Hospital, Memphis, TN, USA.

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http://jbx.sagepub.com/content/19/4/538.full.pdf
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http://jbx.sagepub.com/cgi/doi/10.1177/1087057113520325
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http://dx.doi.org/10.1177/1087057113520325DOI Listing
April 2014

UPLC-MS-ELSD-PDA as a powerful dereplication tool to facilitate compound identification from small-molecule natural product libraries.

J Nat Prod 2014 Apr 11;77(4):902-9. Epub 2014 Mar 11.

National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, §Department of Medicinal Chemistry, ⊥Department of Pharmacognosy, and ∥Department of Pharmacology, School of Pharmacy, The University of Mississippi , University, Mississippi 38677, United States.

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http://dx.doi.org/10.1021/np4009706DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4784093PMC
April 2014

Ligand binding mode prediction by docking: mdm2/mdmx inhibitors as a case study.

J Chem Inf Model 2014 Feb 21;54(2):648-59. Epub 2014 Jan 21.

Department of Structural Biology and ‡Department of Chemical Biology and Therapeutics, Saint Jude Children's Research Hospital , 262 Danny Thomas Place, Memphis, Tennessee 38105, United States.

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http://dx.doi.org/10.1021/ci4004656DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4753531PMC
February 2014

Cheminformatics aspects of high throughput screening: from robots to models: symposium summary.

J Comput Aided Mol Des 2013 May 1;27(5):443-53. Epub 2013 May 1.

Graduate Institute of Biomedical Electronics and Bioinformatics, National Taiwan University, Taipei 106, Taiwan.

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http://dx.doi.org/10.1007/s10822-013-9646-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4205101PMC
May 2013

Global phenotypic screening for antimalarials.

Chem Biol 2012 Jan;19(1):116-29

Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA.

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http://dx.doi.org/10.1016/j.chembiol.2012.01.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3269778PMC
January 2012

An automated approach to efficiently reformat a large collection of compounds.

Curr Chem Genomics 2011 22;5:42-7. Epub 2011 Jul 22.

Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA.

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http://dx.doi.org/10.2174/1875397301105010042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3145259PMC
November 2011

Discovery of potent and selective inhibitors of Trypanosoma brucei ornithine decarboxylase.

J Biol Chem 2010 May 10;285(22):16771-81. Epub 2010 Mar 10.

Department of Chemical Biology and Therapeutics, St Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.

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http://dx.doi.org/10.1074/jbc.M109.081588DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2878083PMC
May 2010

Optimization of a non-radioactive high-throughput assay for decarboxylase enzymes.

Assay Drug Dev Technol 2010 Apr;8(2):175-85

Graduate Program in Chemistry and Chemical Biology, University of California, San Francisco, California, USA.

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http://dx.doi.org/10.1089/adt.2009.0249DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3098607PMC
April 2010

Structure-guided development of selective TbcatB inhibitors.

J Med Chem 2009 Oct;52(20):6489-93

Graduate Program in Chemistry and Chemical Biology, University of California, San Francisco, California 94143-2280, USA.

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http://pubs.acs.org/doi/abs/10.1021/jm900908p
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http://dx.doi.org/10.1021/jm900908pDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2762491PMC
October 2009

A road less traveled by: exploring a decade of Ellman chemistry.

Bioorg Med Chem 2009 Feb 4;17(3):1088-93. Epub 2008 Mar 4.

Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, 332 North Lauderdale Street, Memphis, TN 38105, USA.

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http://dx.doi.org/10.1016/j.bmc.2008.02.087DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2663904PMC
February 2009

Development of potent purine-derived nitrile inhibitors of the trypanosomal protease TbcatB.

J Med Chem 2008 Feb 4;51(3):545-52. Epub 2008 Jan 4.

Graduate Program in Chemistry and Chemical Biology and Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94143-2280, USA.

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http://dx.doi.org/10.1021/jm070760lDOI Listing
February 2008

Assay Optimization and Screening of RNA-Protein Interactions by AlphaScreen.

J Biomol Screen 2007 Oct;12(7):946-55

Graduate Program in Chemistry and Chemical Biology, University of California, San Francisco, USA.

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http://dx.doi.org/10.1177/1087057107306128DOI Listing
October 2007

Scaffold composition and biological relevance of screening libraries.

Nat Chem Biol 2007 Aug;3(8):442-6

Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, 332 North Lauderdale, Memphis, Tennessee 38103, USA.

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http://dx.doi.org/10.1038/nchembio0807-442DOI Listing
August 2007

The interdependence between screening methods and screening libraries.

Curr Opin Chem Biol 2007 Jun 23;11(3):244-51. Epub 2007 May 23.

Department of Chemical Biology and Therapeutics, Saint Jude Children's Research Hospital, Memphis, TN 38103, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S136759310700052
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http://dx.doi.org/10.1016/j.cbpa.2007.05.003DOI Listing
June 2007

Searching for new antimalarial therapeutics amongst known drugs.

Chem Biol Drug Des 2006 Jun;67(6):409-16

Department of Cellular and Molecular Pharmacology, University of California, San Francisco, California 94158-2542, USA.

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http://dx.doi.org/10.1111/j.1747-0285.2006.00391.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1592519PMC
June 2006

A solid-phase approach to the phallotoxins: total synthesis of [Ala7]-phalloidin.

J Org Chem 2005 Jun;70(12):4578-84

Department of Pharmaceutical Chemistry, University of California at San Francisco, California 94143-2280, USA.

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http://dx.doi.org/10.1021/jo0503153DOI Listing
June 2005

Nanomolar affinity small molecule correctors of defective Delta F508-CFTR chloride channel gating.

J Biol Chem 2003 Sep 27;278(37):35079-85. Epub 2003 Jun 27.

Department of Medicine, University of California, San Francisco, California 94143, USA.

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http://dx.doi.org/10.1074/jbc.M303098200DOI Listing
September 2003

Catalysis, specificity, and ACP docking site of Streptomyces coelicolor malonyl-CoA:ACP transacylase.

Structure 2003 Feb;11(2):147-54

Graduate Group in Biophysics, University of California, San Francisco, San Francisco, CA 94143, USA.

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http://dx.doi.org/10.1016/s0969-2126(03)00004-2DOI Listing
February 2003