Publications by authors named "Ana M Gamero"

34Publications

IL-36 promotes anti-viral immunity by boosting sensitivity to IFN-α/β in IRF1 dependent and independent manners.

Nat Commun 2019 10 16;10(1):4700. Epub 2019 Oct 16.

Department of Microbiology and Immunology, Temple University Lewis Katz School of Medicine, Philadelphia, PA, 19140, USA.

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http://dx.doi.org/10.1038/s41467-019-12318-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6795910PMC
October 2019

Characterization of cancer-associated IDH2 mutations that differ in tumorigenicity, chemosensitivity and 2-hydroxyglutarate production.

Oncotarget 2019 Apr 12;10(28):2675-2692. Epub 2019 Apr 12.

Department of Medical Genetics and Molecular Biochemistry, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, USA.

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http://dx.doi.org/10.18632/oncotarget.26848DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6505628PMC
April 2019

Interferon-γ Signaling in Melanocytes and Melanoma Cells Regulates Expression of CTLA-4.

Cancer Res 2018 01 17;78(2):436-450. Epub 2017 Nov 17.

Fels Institute for Cancer Research and Molecular Biology, Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1158/0008-5472.CAN-17-1615DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5771950PMC
January 2018

The Protective Role of Type I Interferons in the Gastrointestinal Tract.

Front Immunol 2017 6;8:410. Epub 2017 Apr 6.

Department of Medical Genetics and Molecular Biochemistry, Temple University School of Medicine, Philadelphia, PA, USA.

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http://dx.doi.org/10.3389/fimmu.2017.00410DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5382159PMC
April 2017

Prostaglandin E2 Inhibition of IL-27 Production in Murine Dendritic Cells: A Novel Mechanism That Involves IRF1.

J Immunol 2017 02 6;198(4):1521-1530. Epub 2017 Jan 6.

Department of Microbiology and Immunology, Lewis Katz School of Medicine, Temple University, Philadelphia, PA 19140;

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http://dx.doi.org/10.4049/jimmunol.1601073DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5296337PMC
February 2017

Phosphorylation of STAT2 on serine-734 negatively regulates the IFN-α-induced antiviral response.

J Cell Sci 2016 11 19;129(22):4190-4199. Epub 2016 Oct 19.

Dept. of Medical Genetics and Molecular Biochemistry, Lewis Katz School of Medicine, Temple University, Philadelphia, PA 19140, USA

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http://dx.doi.org/10.1242/jcs.185421DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6518330PMC
November 2016

STAT2 Is Required for TLR-Induced Murine Dendritic Cell Activation and Cross-Presentation.

J Immunol 2016 07 27;197(1):326-36. Epub 2016 May 27.

Laboratory of Dendritic Cell Biology, Department of Microbiology and Immunology, Lewis Katz School of Medicine, Temple University, Philadelphia, PA 19140;

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http://dx.doi.org/10.4049/jimmunol.1500152DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4912940PMC
July 2016

Stat1 Regulates Lupus-like Chronic Graft-versus-Host Disease Severity via Interactions with Stat3.

J Immunol 2015 Nov 21;195(9):4136-43. Epub 2015 Sep 21.

Section of Rheumatology, Department of Medicine, Temple University, Philadelphia, PA 19140; and.

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http://dx.doi.org/10.4049/jimmunol.1501353DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4610853PMC
November 2015

Type-I interferon signaling through ISGF3 complex is required for sustained Rip3 activation and necroptosis in macrophages.

Proc Natl Acad Sci U S A 2014 Aug 21;111(31):E3206-13. Epub 2014 Jul 21.

Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada K1N 6N5;

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http://www.pnas.org/cgi/doi/10.1073/pnas.1407068111
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http://dx.doi.org/10.1073/pnas.1407068111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4128105PMC
August 2014

An essential role for IFN-β in the induction of IFN-stimulated gene expression by LPS in macrophages.

J Leukoc Biol 2014 Oct 14;96(4):591-600. Epub 2014 Jul 14.

Division of Therapeutic Proteins, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Bethesda, MD, USA;

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http://dx.doi.org/10.1189/jlb.2A0414-191RDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4163629PMC
October 2014

Host STAT2/type I interferon axis controls tumor growth.

Int J Cancer 2015 Jan 17;136(1):117-26. Epub 2014 Jun 17.

Department of Biochemistry, Temple University School of Medicine, Philadelphia, PA.

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http://dx.doi.org/10.1002/ijc.29004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4199898PMC
January 2015

TLR ligands up-regulate Trex1 expression in murine conventional dendritic cells through type I Interferon and NF-κB-dependent signaling pathways.

J Leukoc Biol 2014 Jul 5;96(1):93-103. Epub 2014 Mar 5.

Laboratory of Dendritic Cell Biology, Department of Microbiology and Immunology, and

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http://dx.doi.org/10.1189/jlb.2A0713-393RRDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4056275PMC
July 2014

STAT2 phosphorylation and signaling.

JAKSTAT 2013 Oct 12;2(4):e25790. Epub 2013 Aug 12.

Department of Biochemistry; Temple University School of Medicine; Philadelphia, PA USA.

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http://dx.doi.org/10.4161/jkst.25790DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3876438PMC
October 2013

Stat2 loss leads to cytokine-independent, cell-mediated lethality in LPS-induced sepsis.

Proc Natl Acad Sci U S A 2013 May 7;110(21):8656-61. Epub 2013 May 7.

The Blizard Institute, Barts and the London School of Medicine, Queen Mary, University of London, London E1 2AT, United Kingdom.

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http://dx.doi.org/10.1073/pnas.1221652110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3666758PMC
May 2013

Interferons as inducers of apoptosis in malignant cells.

J Interferon Cytokine Res 2013 Apr;33(4):162-70

Department of Biochemistry, Temple University School of Medicine , Philadelphia, PA 19140, USA.

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http://dx.doi.org/10.1089/jir.2012.0110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3624694PMC
April 2013

The role of signal transducer and activator of transcription-2 in the interferon response.

J Interferon Cytokine Res 2012 Mar 26;32(3):103-10. Epub 2012 Jan 26.

Department of Biochemistry, Temple University School of Medicine, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1089/jir.2011.0099DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3680977PMC
March 2012

Control of type I interferon-induced cell death by Orai1-mediated calcium entry in T cells.

J Biol Chem 2012 Jan 5;287(5):3207-16. Epub 2011 Dec 5.

Department of Biochemistry, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA.

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http://dx.doi.org/10.1074/jbc.M111.269068DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3270975PMC
January 2012

Cecal ligation puncture procedure.

J Vis Exp 2011 May 7(51). Epub 2011 May 7.

Department of Microbiology and Immunology School of Medicine, Temple University, USA.

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http://dx.doi.org/10.3791/2860DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3339843PMC
May 2011

Interferon-lambda as a potential therapeutic agent in cancer treatment.

J Interferon Cytokine Res 2010 Aug;30(8):597-602

Department of Biochemistry, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA.

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http://dx.doi.org/10.1089/jir.2010.0058DOI Listing
August 2010

STAT2 contributes to promotion of colorectal and skin carcinogenesis.

Cancer Prev Res (Phila) 2010 Apr 16;3(4):495-504. Epub 2010 Mar 16.

Temple University School of Medicine, Philadelphia, PA 19140, USA.

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http://dx.doi.org/10.1158/1940-6207.CAPR-09-0105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2851485PMC
April 2010

Resistance to IFN-alpha-induced apoptosis is linked to a loss of STAT2.

Mol Cancer Res 2010 Jan 12;8(1):80-92. Epub 2010 Jan 12.

Laboratory of Experimental Immunology, Cancer and Inflammation Program, National Cancer Institute, NIH, Frederick, Maryland, USA.

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http://dx.doi.org/10.1158/1541-7786.MCR-08-0344DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2808460PMC
January 2010

A Mutation in the SH2 domain of STAT2 prolongs tyrosine phosphorylation of STAT1 and promotes type I IFN-induced apoptosis.

Mol Biol Cell 2007 Jul 18;18(7):2455-62. Epub 2007 Apr 18.

Cancer and Inflammation Program, Laboratory of Experimental Immunology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD 21702, USA.

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http://dx.doi.org/10.1091/mbc.e06-09-0843DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1924825PMC
July 2007

Activation of Tyk2 and Stat3 is required for the apoptotic actions of interferon-beta in primary pro-B cells.

J Biol Chem 2006 Jun 6;281(24):16238-44. Epub 2006 Apr 6.

Laboratory of Experimental Immunology, NCI-Frederick, National Institutes of Health, Frederick, MD 21702, USA.

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http://dx.doi.org/10.1074/jbc.M509516200DOI Listing
June 2006

IL-1 can act as number one.

Immunity 2006 Jan;24(1):16-7

Laboratory of Experimental Immunology, Center for Cancer Research, National Cancer Institute, FCRF, Frederick, Maryland 21702, USA.

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http://dx.doi.org/10.1016/j.immuni.2005.12.007DOI Listing
January 2006

Type I interferons activate apoptosis in a Jurkat cell variant by caspase-dependent and independent mechanisms.

Cell Signal 2006 Aug 6;18(8):1299-308. Epub 2005 Dec 6.

Department of Immunology, Lerner Research Institute, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA.

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http://dx.doi.org/10.1016/j.cellsig.2005.10.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1862448PMC
August 2006

Calcium-dependent activation of interleukin-21 gene expression in T cells.

J Biol Chem 2005 Jul 6;280(26):25291-7. Epub 2005 May 6.

Laboratory of Molecular Immunology, NHLBI, National Institutes of Health, Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.1074/jbc.M501459200DOI Listing
July 2005

Inactivation of Stat3 in tumor cells: releasing a brake on immune responses against cancer?

Cancer Cell 2004 Feb;5(2):111-2

Laboratory of Experimental Immunology, National Cancer Institute, Center for Cancer Research, Frederick, MD 21702, USA.

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http://dx.doi.org/10.1016/s1535-6108(04)00028-5DOI Listing
February 2004

Thrombomodulin RNA is destabilized through its 3'-untranslated element in cells exposed to IFN-gamma.

J Interferon Cytokine Res 2003 Dec;23(12):723-8

Department of Immunology/NB30, The Cleveland Clinic Foundation, OH 44195, USA.

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http://dx.doi.org/10.1089/107999003772084833DOI Listing
December 2003

Identification of a novel conserved motif in the STAT family that is required for tyrosine phosphorylation.

J Biol Chem 2004 Mar 13;279(13):12379-85. Epub 2004 Jan 13.

Department of Immunology, Lerner Research Institute, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA.

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http://www.jbc.org/content/279/13/12379.full.pdf
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http://www.jbc.org/content/early/2004/01/13/jbc.M310787200.f
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http://www.jbc.org/cgi/doi/10.1074/jbc.M310787200
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http://dx.doi.org/10.1074/jbc.M310787200DOI Listing
March 2004

Effects of interferon beta on transcobalamin II-receptor expression and antitumor activity of nitrosylcobalamin.

J Natl Cancer Inst 2002 Jul;94(13):1010-9

Taussig Cancer Center, Center for Cancer Drug Discovery and Development, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2020433PMC
http://dx.doi.org/10.1093/jnci/94.13.1010DOI Listing
July 2002