Publications by authors named "Ana Losada"

64Publications

Skeletal Anomalies in Senegalese Sole ( Kaup) Fed with Different Commercial Enriched A Study in Postlarvae and Juveniles.

Animals (Basel) 2020 Dec 24;11(1). Epub 2020 Dec 24.

Department of Anatomy, Animal Production and Clinical Veterinary Sciences, Faculty of Veterinary Science, University of Santiago de Compostela, Campus Universitario S/N, 27002 Lugo, Spain.

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December 2020

The Teleost Thymus in Health and Disease: New Insights from Transcriptomic and Histopathological Analyses of Turbot, .

Biology (Basel) 2020 Aug 13;9(8). Epub 2020 Aug 13.

Departamento de Anatomía, Producción Animal y Ciencias Clínicas Veterinarias, Universidade de Santiago de Compostela, 27002 Lugo, Spain.

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August 2020

Specialized functions of cohesins STAG1 and STAG2 in 3D genome architecture.

Curr Opin Genet Dev 2020 04 12;61:9-16. Epub 2020 Apr 12.

Chromosome Dynamics Group, Molecular Oncology Programme, Spanish National Cancer Research Centre (CNIO), Melchor Fernández Almagro 3, 28029 Madrid, Spain. Electronic address:

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April 2020

PDS5 proteins regulate the length of axial elements and telomere integrity during male mouse meiosis.

EMBO Rep 2020 06 14;21(6):e49273. Epub 2020 Apr 14.

Unidad de Biología Celular, Departamento de Biología, Facultad de Ciencias, Universidad Autónoma de Madrid, Madrid, Spain.

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June 2020

Effects of Enteromyxum spp. (Myxozoa) infection in the regulation of intestinal E-cadherin: Turbot against gilthead sea bream.

J Fish Dis 2020 Mar 26;43(3):337-346. Epub 2020 Jan 26.

Departamento de Anatomía, Producción Animal y Ciencias Clínicas Veterinarias, Universidade de Santiago de Compostela, Lugo, Spain.

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March 2020

PDS5 proteins are required for proper cohesin dynamics and participate in replication fork protection.

J Biol Chem 2020 01 22;295(1):146-157. Epub 2019 Nov 22.

Chromosome Dynamics Group, Spanish National Cancer Research Centre (CNIO), Melchor Fernández Almagro 3, 28029 Madrid, Spain

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January 2020

Specific Contributions of Cohesin-SA1 and Cohesin-SA2 to TADs and Polycomb Domains in Embryonic Stem Cells.

Cell Rep 2019 06;27(12):3500-3510.e4

Chromosome Dynamics Group, Molecular Oncology Programme, Spanish National Cancer Research Centre (CNIO), Melchor Fernández Almagro 3, 28029 Madrid, Spain. Electronic address:

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June 2019

Corrigendum: Integrating Genomic and Morphological Approaches in Fish Pathology Research: The Case of Turbot () Enteromyxosis.

Front Genet 2019 20;10:225. Epub 2019 Mar 20.

Departamento de Anatomía, Producción Animal y Ciencias Clínicas Veterinarias, Universidade de Santiago de Compostela, Lugo, Spain.

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March 2019

Integrating Genomic and Morphological Approaches in Fish Pathology Research: The Case of Turbot () Enteromyxosis.

Front Genet 2019 31;10:26. Epub 2019 Jan 31.

Departamento de Anatomía, Producción Animal y Ciencias Clínicas Veterinarias, Universidade de Santiago de Compostela, Lugo, Spain.

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January 2019

Skeletal Anomalies in Senegalese Sole ( Solea senegalensis), an Anosteocytic Boned Flatfish Species.

Vet Pathol 2019 03 3;56(2):307-316. Epub 2018 Oct 3.

1 Departamento de Anatomía, Producción Animal y Ciencias Clínicas Veterinarias, Facultade de Veterinaria, Universidade de Santiago de Compostela, Lugo, Spain.

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March 2019

First description of a natural infection with spleen and kidney necrosis virus in zebrafish.

J Fish Dis 2018 Jun 7. Epub 2018 Jun 7.

Department of Anatomy, Animal Production and Veterinary Clinical Sciences, Faculty of Veterinary, University of Santiago de Compostela, Lugo, Spain.

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June 2018

Distinct roles of cohesin-SA1 and cohesin-SA2 in 3D chromosome organization.

Nat Struct Mol Biol 2018 06 4;25(6):496-504. Epub 2018 Jun 4.

Chromosome Dynamics Group, Molecular Oncology Program, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.

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June 2018

Establishing and dissolving cohesion during the vertebrate cell cycle.

Curr Opin Cell Biol 2018 06 10;52:51-57. Epub 2018 Feb 10.

Chromosome Dynamics Group, Molecular Oncology Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain. Electronic address:

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June 2018

Susceptibility of Zebrafish to Vesicular Stomatitis Virus Infection.

Zebrafish 2018 04 5;15(2):124-132. Epub 2018 Jan 5.

1 Departamento de Zoología, Genética y Antropología Física, Facultad de Veterinaria, Universidade de Santiago de Compostela , Lugo, Spain .

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April 2018

The human Cranio Facial Development Protein 1 (Cfdp1) gene encodes a protein required for the maintenance of higher-order chromatin organization.

Sci Rep 2017 04 3;7:45022. Epub 2017 Apr 3.

Istituto Pasteur Italia-Fondazione Cenci Bolognetti and Dipartimento di Biologia e Biotecnologie "Charles Darwin", Sapienza Università di Roma, Italy.

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April 2017

Cohesin Mutations in Cancer.

Cold Spring Harb Perspect Med 2016 Dec 1;6(12). Epub 2016 Dec 1.

Chromosome Dynamics Group, Molecular Oncology Programme, Spanish National Cancer Research Centre (CNIO), Madrid E-28029, Spain.

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December 2016

Immunohistochemical study of inducible nitric oxide synthase and tumour necrosis factor alpha response in turbot (Scophthalmus maximus) experimentally infected with Aeromonas salmonicida subsp. salmonicida.

Fish Shellfish Immunol 2016 Sep 16;56:294-302. Epub 2016 Jul 16.

Departamento de Ciencias Clínicas Veterinarias, Facultad de Veterinaria, Universidad de Santiago de Compostela, Campus Universitario s/n, 27002, Lugo, Spain.

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September 2016

Bub1 targeting to centromeres is sufficient for Sgo1 recruitment in the absence of kinetochores.

Chromosoma 2017 03 26;126(2):279-286. Epub 2016 Apr 26.

Chromosome Dynamics Group, Molecular Oncology Programme, Spanish National Cancer Research Centre (CNIO), Melchor Fernández Almagro 3, 28029, Madrid, Spain.

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March 2017

Immunohistochemical detection and gene expression of TNFα in turbot (Scophthalmus maximus) enteromyxosis.

Fish Shellfish Immunol 2015 Nov 16;47(1):368-76. Epub 2015 Sep 16.

Departamento de Ciencias Clínicas Veterinarias, Facultad de Veterinaria, Universidad de Santiago de Compostela, 27002, Lugo, Spain. Electronic address:

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November 2015

Immunolocalization of tumor necrosis factor alpha in turbot (Scophthalmus maximus, L.) tissues.

Fish Shellfish Immunol 2015 Aug 7;45(2):470-6. Epub 2015 May 7.

Departamento de Ciencias Clínicas Veterinarias, Facultad de Veterinaria, Universidad de Santiago de Compostela, 27002, Lugo, Spain. Electronic address:

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August 2015

The contribution of cohesin-SA1 to gene expression and chromatin architecture in two murine tissues.

Nucleic Acids Res 2015 Mar 3;43(6):3056-67. Epub 2015 Mar 3.

Chromosome Dynamics Group, Molecular Oncology Programme, Spanish National Cancer Research Centre (CNIO), Melchor Fernández Almagro 3, 28029 Madrid, Spain

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March 2015

The distinct functions of CENP-C and CENP-T/W in centromere propagation and function in Xenopus egg extracts.

Nucleus 2015 8;6(2):133-43. Epub 2015 Jan 8.

a Chromosome Dynamics Group ; Molecular Oncology Program ; Spanish National Cancer Research Center (CNIO) ; Madrid , Spain.

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January 2016

RNA-seq analysis reveals significant transcriptome changes in turbot (Scophthalmus maximus) suffering severe enteromyxosis.

BMC Genomics 2014 Dec 19;15:1149. Epub 2014 Dec 19.

Departamento de Ciencias Clínicas Veterinarias, Facultad de Veterinaria, Universidad de Santiago de Compostela, Lugo 27002, Spain.

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December 2014

Evaluation of immune response in turbot (Psetta maxima L.) tenacibaculosis: haematological and immunohistochemical studies.

Microb Pathog 2014 Nov 16;76:1-9. Epub 2014 Sep 16.

Departamento de Ciencias Clínicas Veterinarias, Facultad de Veterinaria, Universidad de Santiago de Compostela, 27002 Lugo, Spain. Electronic address:

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November 2014

Cohesin in cancer: chromosome segregation and beyond.

Authors:
Ana Losada

Nat Rev Cancer 2014 Jun;14(6):389-93

Chromosome Dynamics Group, Molecular Oncology Programme, Spanish National Cancer Research Centre (CNIO), 28029 Madrid, Spain.

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June 2014

T-cell profiling and the immunodiagnosis of latent tuberculosis infection in patients with inflammatory bowel disease.

Inflamm Bowel Dis 2014 Feb;20(2):329-38

*Department of Respiratory Medicine, Instituto Nacional de Silicosis, Hospital Universitario Central de Asturias, Oviedo, Spain; †Department of Digestive Diseases, Hospital Universitario Central de Asturias, Oviedo, Spain; ‡Department of Microbiology, Mycobacterial Reference Unit, Hospital Universitario Central de Asturias, Oviedo, Spain; §Department of Respiratory Medicine, Hospital Arnau de Villanova, Valencia, Spain; ‖Division of Pulmonary and Critical Care Medicine and Mayo Clinic Center for Tuberculosis, Mayo Clinic, Rochester, Minnesota; ¶Department of Radiology, Hospital Universitario Central de Asturias, Oviedo; and **Oficina de Investigación Biosanitaria, Hospital Universitario Central de Asturias, Oviedo, Spain.

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February 2014

Pds5B is required for cohesion establishment and Aurora B accumulation at centromeres.

EMBO J 2013 Nov 18;32(22):2938-49. Epub 2013 Oct 18.

Chromosome Dynamics Group, Molecular Oncology Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.

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November 2013

Tenacibaculum maritimum infection: pathology and immunohistochemistry in experimentally challenged turbot (Psetta maxima L.).

Microb Pathog 2013 Dec 1;65:82-8. Epub 2013 Oct 1.

Departamento de Ciencias Clínicas Veterinarias, Facultad de Veterinaria, Universidad de Santiago de Compostela, 27002 Lugo, Spain. Electronic address:

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December 2013

Cohesin in development and disease.

Development 2013 Sep;140(18):3715-8

Chromosome Dynamics Group, Molecular Oncology Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.

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September 2013

Reduction of Nipbl impairs cohesin loading locally and affects transcription but not cohesion-dependent functions in a mouse model of Cornelia de Lange Syndrome.

Biochim Biophys Acta 2013 Dec 3;1832(12):2097-102. Epub 2013 Aug 3.

Chromosome Dynamics Group, Molecular Oncology Programme, Spanish National Cancer Research Centre (CNIO), Melchor Fernández Almagro 3, 28029 Madrid, Spain.

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December 2013

Understanding chromatin and chromosomes: from static views to dynamic thinking.

EMBO Rep 2013 Feb 15;14(2):109-11. Epub 2013 Jan 15.

European Molecular Biology Laboratory, Heidelberg, Germany.

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February 2013

Cohesin, a chromatin engagement ring.

Curr Opin Cell Biol 2013 Feb 6;25(1):63-71. Epub 2012 Dec 6.

Chromosome Dynamics Group, Molecular Oncology Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.

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February 2013

The specific contributions of cohesin-SA1 to cohesion and gene expression: implications for cancer and development.

Cell Cycle 2012 Jun 15;11(12):2233-8. Epub 2012 Jun 15.

Chromosome Dynamics Group, Molecular Oncology Programme, Spanish National Cancer Research Centre, Madrid, Spain.

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June 2012

A unique role of cohesin-SA1 in gene regulation and development.

EMBO J 2012 May 13;31(9):2090-102. Epub 2012 Mar 13.

Chromosome Dynamics Group, Molecular Oncology Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.

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May 2012

Cohesin-SA1 deficiency drives aneuploidy and tumourigenesis in mice due to impaired replication of telomeres.

EMBO J 2012 May 13;31(9):2076-89. Epub 2012 Mar 13.

Chromosome Dynamics Group, Molecular Oncology Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.

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May 2012

Xenopus Shugoshin 2 regulates the spindle assembly pathway mediated by the chromosomal passenger complex.

EMBO J 2012 Mar 24;31(6):1467-79. Epub 2012 Jan 24.

Chromosome Dynamics Group, Molecular Oncology Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.

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March 2012

Morphological and immunohistochemical characterisation of the thymus in juvenile turbot (Psetta maxima, L.).

Cell Tissue Res 2011 Dec 10;346(3):407-16. Epub 2011 Dec 10.

Cátedra de Histología y Embriología, Facultad de Ciencias Veterinarias, Universidad Nacional de Rosario, Casilda, Argentina.

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December 2011

New clues to understand how CENP-A maintains centromere identity.

Cell Div 2011 May 9;6(1):11. Epub 2011 May 9.

Chromosome Dynamics Group, Molecular Oncology Programme, Spanish National Cancer Research Centre (CNIO), Melchor Fernández Almagro 3, Madrid, E-28029, Spain.

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May 2011

Smc5 flies solo.

Cell Cycle 2011 Mar 15;10(6):874-5. Epub 2011 Mar 15.

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March 2011

Xenopus HJURP and condensin II are required for CENP-A assembly.

J Cell Biol 2011 Feb 14;192(4):569-82. Epub 2011 Feb 14.

Molecular Oncology Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.

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February 2011

Cohesin organizes chromatin loops at DNA replication factories.

Genes Dev 2010 Dec;24(24):2812-22

DNA Replication Group, Spanish National Cancer Research Centre (CNIO), E-28029 Madrid, Spain.

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December 2010

Recycling cohesin rings by deacetylation.

Mol Cell 2010 Sep;39(5):657-9

Chromosome Dynamics Group, Molecular Oncology Programme, Spanish National Cancer Research Centre CNIO, 28029 Madrid, Spain.

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September 2010

Cohesin ties up the genome.

Curr Opin Cell Biol 2010 Dec 31;22(6):781-7. Epub 2010 Jul 31.

Chromosome Dynamics Group, Molecular Oncology Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.

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December 2010

Tipin/Tim1/And1 protein complex promotes Pol alpha chromatin binding and sister chromatid cohesion.

EMBO J 2009 Dec 5;28(23):3681-92. Epub 2009 Nov 5.

Genome Stability and Cell Cycle Control Groups, Cancer Research UK, Clare Hall Laboratories, South Mimms, Herts, UK.

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December 2009

Epigenetic specification of centromeres by CENP-A.

Exp Cell Res 2009 Nov 3;315(19):3233-41. Epub 2009 Aug 3.

Molecular Oncology Programme, Spanish National Cancer Research Center (CNIO), Madrid, Spain.

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November 2009

Heterochromatin protein 1 (HP1) proteins do not drive pericentromeric cohesin enrichment in human cells.

PLoS One 2009 8;4(4):e5118. Epub 2009 Apr 8.

Chromosome Dynamics Group, Molecular Oncology Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.

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July 2009

Shugoshin regulates cohesion by driving relocalization of PP2A in Xenopus extracts.

Chromosoma 2009 Apr 6;118(2):223-33. Epub 2008 Nov 6.

Spanish National Cancer Research Centre, Madrid, Spain.

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April 2009

The regulation of sister chromatid cohesion.

Authors:
Ana Losada

Biochim Biophys Acta 2008 Sep 24;1786(1):41-8. Epub 2008 Apr 24.

Chromosome Dynamics Group, Spanish National Cancer Research Centre, Melchor Fernández Almagro 3, Madrid E-28029, Spain.

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September 2008

Cohesin regulation: fashionable ways to wear a ring.

Authors:
Ana Losada

Chromosoma 2007 Aug 1;116(4):321-9. Epub 2007 Mar 1.

Spanish National Cancer Research Center, Melchor Fernández Almagro 3, Madrid, 28029, Spain.

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August 2007

Shugoshin and PP2A, shared duties at the centromere.

Bioessays 2006 Aug;28(8):775-9

Chromosome Dynamics Group, Spanish National Cancer Center (CNIO), Madrid, Spain.

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August 2006

Dynamic molecular linkers of the genome: the first decade of SMC proteins.

Genes Dev 2005 Jun;19(11):1269-87

Spanish National Cancer Center (CNIO), Madrid.

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June 2005

Functional contribution of Pds5 to cohesin-mediated cohesion in human cells and Xenopus egg extracts.

J Cell Sci 2005 May 26;118(Pt 10):2133-41. Epub 2005 Apr 26.

Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11724, USA.

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May 2005

Differential contributions of condensin I and condensin II to mitotic chromosome architecture in vertebrate cells.

Cell 2003 Oct;115(1):109-21

Cold Spring Harbor Laboratory, One Bungtown Road, PO Box 100, Cold Spring Harbor, NY 11724, USA.

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October 2003

Condensin and cohesin display different arm conformations with characteristic hinge angles.

J Cell Biol 2002 Feb 28;156(3):419-24. Epub 2002 Jan 28.

Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA.

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February 2002