Ana I Robles

Ana I Robles

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Ana I Robles

Ana I Robles

Publications by authors named "Ana I Robles"

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Integrated Proteogenomic Characterization of HBV-Related Hepatocellular Carcinoma.

Cell 2019 Oct;179(2):561-577.e22

Department of Liver Surgery and Transplantation, Liver Cancer Institute, Zhongshan Hospital, Fudan University, and Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education, 180 Fenglin Road, Shanghai 200032, China; Key Laboratory of Medical Epigenetics and Metabolism, Institutes of Biomedical Sciences, Fudan University, Shanghai 200032, China. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2019.08.052DOI Listing
October 2019

Prenatal smoke exposure, DNA methylation and a link between DRD1 and lung cancer.

Int J Epidemiol 2019 08;48(4):1377-1378

Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA.

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https://academic.oup.com/ije/advance-article/doi/10.1093/ije
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http://dx.doi.org/10.1093/ije/dyz035DOI Listing
August 2019

Comprehensive genomic analysis of circulating tumor DNA for patients with advanced non-small cell lung cancer.

Ann Transl Med 2019 Mar;7(5):80

Office of Cancer Clinical Proteomics Research, National Cancer Institute, NIH, Bethesda, MD, USA.

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http://dx.doi.org/10.21037/atm.2018.12.57DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6462649PMC
March 2019

Epigenetic predictive biomarkers for response or outcome to platinum-based chemotherapy in non-small cell lung cancer, current state-of-art.

Pharmacogenomics J 2019 02 7;19(1):5-14. Epub 2018 Sep 7.

Department of Oncology, Aalborg University Hospital, Hobrovej 18-22, 9000, Aalborg, Denmark.

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http://dx.doi.org/10.1038/s41397-018-0029-1DOI Listing
February 2019

A Nucleolar Stress-Specific p53-miR-101 Molecular Circuit Functions as an Intrinsic Tumor-Suppressor Network.

EBioMedicine 2018 Jul 7;33:33-48. Epub 2018 Jul 7.

Laboratory of Molecular Carcinogenesis, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.ebiom.2018.06.031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6085539PMC
July 2018

Inverse association of vitamin D levels with lung cancer mediated by genetic variation.

Cancer Med 2018 06 3;7(6):2764-2775. Epub 2018 May 3.

Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, 20892.

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http://dx.doi.org/10.1002/cam4.1444DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6010700PMC
June 2018

Mutant p53 cancers reprogram macrophages to tumor supporting macrophages via exosomal miR-1246.

Nat Commun 2018 02 22;9(1):771. Epub 2018 Feb 22.

Laboratory of Human Carcinogenesis, NCI-CCR, National Institutes of Health, Bethesda, 20892-4258, MD, USA.

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http://dx.doi.org/10.1038/s41467-018-03224-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5823939PMC
February 2018

Sputum-based DNA methylation biomarkers to guide lung cancer screening decisions.

J Thorac Dis 2017 Nov;9(11):4308-4310

Laboratory of Human Carcinogenesis, National Cancer Institute, NIH, Bethesda, USA.

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http://dx.doi.org/10.21037/jtd.2017.10.78DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5721009PMC
November 2017

Interleukins as new prognostic genetic biomarkers in non-small cell lung cancer.

Surg Oncol 2017 Sep 22;26(3):278-285. Epub 2017 May 22.

Department of Pharmacology, Faculty of Pharmacy, University of Granada, Campus Universitario de Cartuja, s/n, 18071 Granada, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.suronc.2017.05.004DOI Listing
September 2017

Lung Cancer Field Cancerization: Implications for Screening by Low-Dose Computed Tomography.

J Natl Cancer Inst 2017 07;109(7)

Laboratory of Human Carcinogenesis, NCI-CCR, National Institutes of Health, Bethesda, MD, USA.

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http://dx.doi.org/10.1093/jnci/djw328DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6059243PMC
July 2017

Δ133p53 represses p53-inducible senescence genes and enhances the generation of human induced pluripotent stem cells.

Cell Death Differ 2017 06 31;24(6):1017-1028. Epub 2017 Mar 31.

Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.

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http://www.nature.com/doifinder/10.1038/cdd.2017.48
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http://dx.doi.org/10.1038/cdd.2017.48DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5442472PMC
June 2017

Seeing the Forest through the Phylogenetic Tree.

N Engl J Med 2017 06;376(22):2190-2191

From the Laboratory of Human Carcinogenesis, Center for Cancer Research (A.I.R.), and the Center for Cancer Genomics (J.C.Z.), National Cancer Institute, National Institutes of Health, Bethesda, MD.

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http://dx.doi.org/10.1056/NEJMe1704618DOI Listing
June 2017

Integration of multiple "OMIC" biomarkers: A precision medicine strategy for lung cancer.

Lung Cancer 2017 05 14;107:50-58. Epub 2016 Jun 14.

Laboratory of Human Carcinogenesis, National Cancer Institute, NIH, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1016/j.lungcan.2016.06.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5156586PMC
May 2017

Contribution of genetic factors to platinum-based chemotherapy sensitivity and prognosis of non-small cell lung cancer.

Mutat Res 2017 Jan - Mar;771:32-58. Epub 2016 Nov 23.

UGC Provincial de Farmacia de Granada, Instituto de Investigación Biosanitaria de Granada, Complejo Hospitalario Universitario de Granada, Avda. Fuerzas Armadas, 2, Spain; Department of Pharmacology, Faculty of Pharmacy, University of Granada, Campus Universitario de Cartuja, s/n, 18071 Granada, Spain. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S13835742163008
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http://dx.doi.org/10.1016/j.mrrev.2016.11.003DOI Listing
May 2017

Methylation analyses in liquid biopsy.

Transl Lung Cancer Res 2016 Oct;5(5):492-504

Laboratory of Human Carcinogenesis, National Cancer Institute, NIH, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.21037/tlcr.2016.10.03DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5099516PMC
October 2016

Liquid biopsy in early stage lung cancer.

Transl Lung Cancer Res 2016 Oct;5(5):517-524

Pharmacogenetics Unit, UGC Provincial de Farmacia de Granada, Instituto de Investigación Biosanitaria de Granada, Complejo Hospitalario Universitario de Granada, Avda. Fuerzas Armadas, 2, 18014 Granada, Spain;; Department of Pharmacology, Faculty of Pharmacy, University of Granada, Campus Universitario de Cartuja, s/n, 18071 Granada, Spain.

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http://tlcr.amegroups.com/article/view/10207/8675
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http://dx.doi.org/10.21037/tlcr.2016.10.15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5099510PMC
October 2016

Clinical Outcomes of TP53 Mutations in Cancers.

Cold Spring Harb Perspect Med 2016 Sep 1;6(9). Epub 2016 Sep 1.

Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892.

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http://dx.doi.org/10.1101/cshperspect.a026294DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5008065PMC
September 2016

The Werner syndrome RECQ helicase targets G4 DNA in human cells to modulate transcription.

Hum Mol Genet 2016 05 16;25(10):2060-2069. Epub 2016 Mar 16.

Department of Pathology, Department of Genome Sciences, University of Washington, Seattle, WA, USA,

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http://dx.doi.org/10.1093/hmg/ddw079DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5062591PMC
May 2016

Whole-Exome Sequencing Analyses of Inflammatory Bowel Disease-Associated Colorectal Cancers.

Gastroenterology 2016 Apr 5;150(4):931-43. Epub 2016 Jan 5.

Ludwig Center at Johns Hopkins, Baltimore, Maryland; Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2015.12.036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5270616PMC
April 2016

An Integrated Prognostic Classifier for Stage I Lung Adenocarcinoma Based on mRNA, microRNA, and DNA Methylation Biomarkers.

J Thorac Oncol 2015 Jul;10(7):1037-48

*Laboratory of Human Carcinogenesis, NCI-CCR, National Institutes of Health, Bethesda, Maryland; †Division of Molecular Pathology, National Cancer Center Research Institute, Tokyo, Japan; ‡Genetics Branch, NCI-CCR, National Institutes of Health, Bethesda, Maryland; §Division of Genome Biology, National Cancer Center Research Institute, Tokyo, Japan; ‖Department of Chemical and Biological Working Environment, National Institute of Occupational Health, Oslo, Norway; and ¶Genomics and Epigenomics of Cancer Prediction Program, Institute of Predictive and Personalized Medicine of Cancer (IMPPC), Badalona (Barcelona), Spain.

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http://dx.doi.org/10.1097/JTO.0000000000000560DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4493931PMC
July 2015

Expression and clinical significance of genes frequently mutated in small cell lung cancers defined by whole exome/RNA sequencing.

Carcinogenesis 2015 Jun 11;36(6):616-21. Epub 2015 Apr 11.

Division of Genome Biology, National Cancer Center Research Institute, Tokyo 104-0045, Japan, Cancer Genome Biology Group, Institute of Predictive and Personalized Medicine of Cancer, 08916 Barcelona, Spain

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http://dx.doi.org/10.1093/carcin/bgv026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4462675PMC
June 2015

The expression of four genes as a prognostic classifier for stage I lung adenocarcinoma in 12 independent cohorts.

Cancer Epidemiol Biomarkers Prev 2014 Dec 21;23(12):2884-94. Epub 2014 Sep 21.

Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland.

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http://dx.doi.org/10.1158/1055-9965.EPI-14-0182DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4257875PMC
December 2014

miRNA signature of mouse helper T cell hyper-proliferation.

PLoS One 2013 25;8(6):e66709. Epub 2013 Jun 25.

Laboratory of Cellular and Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0066709PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3692518PMC
February 2014

A primate-specific microRNA enters the lung cancer landscape.

Proc Natl Acad Sci U S A 2013 Nov 4;110(47):18748-9. Epub 2013 Nov 4.

Laboratory of Human Carcinogenesis, National Cancer Institute, Center for Cancer Research, National Institutes of Health, Bethesda, MD 20892.

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http://www.pnas.org/content/110/47/18748.full.pdf
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http://www.pnas.org/cgi/doi/10.1073/pnas.1318740110
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http://dx.doi.org/10.1073/pnas.1318740110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3839723PMC
November 2013

Inflammation-mediated genetic and epigenetic alterations drive cancer development in the neighboring epithelium upon stromal abrogation of TGF-β signaling.

PLoS Genet 2013 7;9(2):e1003251. Epub 2013 Feb 7.

Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.

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http://dx.doi.org/10.1371/journal.pgen.1003251DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3567148PMC
June 2013

MDM2 SNP285 does not antagonize the effect of SNP309 in lung cancer.

Int J Cancer 2012 Dec 27;131(11):2710-6. Epub 2012 Apr 27.

Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-4258, USA.

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http://dx.doi.org/10.1002/ijc.27573DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3414691PMC
December 2012

rs4919510 in hsa-mir-608 is associated with outcome but not risk of colorectal cancer.

PLoS One 2012 11;7(5):e36306. Epub 2012 May 11.

Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0036306PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3350523PMC
October 2012

Functional interaction of tumor suppressor DLC1 and caveolin-1 in cancer cells.

Cancer Res 2012 Sep 12;72(17):4405-16. Epub 2012 Jun 12.

Laboratory of Cellular Oncology, Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-12-0777DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6264793PMC
September 2012

KRAS-LCS6 genotype as a prognostic marker in early-stage CRC--letter.

Clin Cancer Res 2012 Jun 5;18(12):3487-8; author reply 3489. Epub 2012 Jun 5.

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http://dx.doi.org/10.1158/1078-0432.CCR-12-0250DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4132878PMC
June 2012

Genetic variation in microRNA networks: the implications for cancer research.

Nat Rev Cancer 2010 Jun;10(6):389-402

Cancer Prevention Fellowship Program, Center for Cancer Training, National Cancer Institute, National Institutes of Health, 37 Convent Drive, Building 37, Room 3068A, Bethesda, MD 20892-4258, USA.

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http://dx.doi.org/10.1038/nrc2867DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2950312PMC
June 2010

Clinical outcomes and correlates of TP53 mutations and cancer.

Cold Spring Harb Perspect Biol 2010 Mar;2(3):a001016

Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.1101/cshperspect.a001016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2829964PMC
March 2010

Microenvironmental modulation of asymmetric cell division in human lung cancer cells.

Proc Natl Acad Sci U S A 2010 Feb 13;107(5):2195-200. Epub 2010 Jan 13.

Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1073/pnas.0909390107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2836660PMC
February 2010

WNT16B is a new marker of cellular senescence that regulates p53 activity and the phosphoinositide 3-kinase/AKT pathway.

Cancer Res 2009 Dec;69(24):9183-91

Centre de Recherche Institut National de la Sante et de la Recherche Medicale/UJF-U823, Institut Albert Bonniot, La Tronche, Grenoble, France.

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http://dx.doi.org/10.1158/0008-5472.CAN-09-1016DOI Listing
December 2009

A novel ING2 isoform, ING2b, synergizes with ING2a to prevent cell cycle arrest and apoptosis.

FEBS Lett 2008 Nov 23;582(28):3868-74. Epub 2008 Oct 23.

Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, NIH, 37 Convent Dr., Bldg. 37, Rm. 3068, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1016/j.febslet.2008.10.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2613974PMC
November 2008

Molecular analysis reveals heterogeneity of mouse mammary tumors conditionally mutant for Brca1.

Mol Cancer 2008 Apr 7;7:29. Epub 2008 Apr 7.

Center for Cancer Research, National Cancer Institute, 9000 Rockville Pike, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1186/1476-4598-7-29DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2329667PMC
April 2008

Harnessing genetically engineered mouse models for preclinical testing.

Chem Biol Interact 2008 Jan 8;171(2):159-64. Epub 2007 Feb 8.

Laboratory of Human Carcinogenesis, Center for Cancer Research, NCI, NIH, 37 Convent Drive, Room 3060, Bethesda, MD 20892, United States.

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http://dx.doi.org/10.1016/j.cbi.2007.01.014DOI Listing
January 2008

Schedule-dependent synergy between the heat shock protein 90 inhibitor 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin and doxorubicin restores apoptosis to p53-mutant lymphoma cell lines.

Clin Cancer Res 2006 Nov;12(21):6547-56

Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute and Hematology Branch, National Heart, Lung and Blood Institute, NIH, Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-06-1178DOI Listing
November 2006

Nitric oxide is a signaling molecule that regulates gene expression.

Methods Enzymol 2005 ;396:326-40

College of Pharmacy, University of South Carolina, Columbia, SC 29208, USA.

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http://dx.doi.org/10.1016/S0076-6879(05)96027-8DOI Listing
January 2006

Apoptotic signaling pathways induced by nitric oxide in human lymphoblastoid cells expressing wild-type or mutant p53.

Cancer Res 2004 May;64(9):3022-9

Biological Engineering Division and Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139-4307, USA.

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http://dx.doi.org/10.1158/0008-5472.can-03-1880DOI Listing
May 2004

p53: at the crossroads of molecular carcinogenesis and molecular epidemiology.

Chest 2004 May;125(5 Suppl):83S-5S

Laboratory of Human Carcinogenesis, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-4255, USA.

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http://dx.doi.org/10.1378/chest.125.5_suppl.83s-aDOI Listing
May 2004

Deconstruction of p53 functions and regulation.

Oncogene 2002 Nov;21(54):8223-31

The Hebrew University - Hadassah Medical School, Jerusalem, Israel.

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http://search.proquest.com/openview/a0db673f5e934f1682f56f2b
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http://www.nature.com/doifinder/10.1038/sj.onc.1206137
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http://dx.doi.org/10.1038/sj.onc.1206137DOI Listing
November 2002

The p53 network in lung carcinogenesis.

Oncogene 2002 Oct;21(45):6898-907

Laboratory of Human Carcinogenesis, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.

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http://www.nature.com/articles/1205563
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http://dx.doi.org/10.1038/sj.onc.1205563DOI Listing
October 2002

Laser capture microdissection and microarray expression analysis of lung adenocarcinoma reveals tobacco smoking- and prognosis-related molecular profiles.

Cancer Res 2002 Jun;62(11):3244-50

Laboratory of Human Carcinogenesis, Biometric Research Branch, Division of Cancer Treatment and Diagnosis National Cancer Institute, NIH, 37 Convent Drive, Bethesda, MD 20892, USA..

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June 2002