Publications by authors named "An Snellinx"

17Publications

Spatial Transcriptomics and In Situ Sequencing to Study Alzheimer's Disease.

Authors:
Wei-Ting Chen Ashley Lu Katleen Craessaerts Benjamin Pavie Carlo Sala Frigerio Nikky Corthout Xiaoyan Qian Jana Laláková Malte Kühnemund Iryna Voytyuk Leen Wolfs Renzo Mancuso Evgenia Salta Sriram Balusu An Snellinx Sebastian Munck Aleksandra Jurek Jose Fernandez Navarro Takaomi C Saido Inge Huitinga Joakim Lundeberg Mark Fiers Bart De Strooper

Cell 2020 Aug 22;182(4):976-991.e19. Epub 2020 Jul 22.

VIB Center for Brain & Disease Research, Leuven 3000, Belgium; KU Leuven, Department of Neurosciences, Leuven Brain Institute, Leuven 3000, Belgium; UK Dementia Research Institute at University College London, London WC1E 6BT, UK. Electronic address:

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August 2020

BACE2 distribution in major brain cell types and identification of novel substrates.

Authors:
Iryna Voytyuk Stephan A Mueller Julia Herber An Snellinx Dieder Moechars Geert van Loo Stefan F Lichtenthaler Bart De Strooper

Life Sci Alliance 2018 Jan 15;1(1):e201800026. Epub 2018 Feb 15.

Department of Neurosciences, Katholieke Universiteit Leuven, Leuven, Belgium.

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January 2018

Synaptogyrin-3 Mediates Presynaptic Dysfunction Induced by Tau.

Authors:
Joseph McInnes Keimpe Wierda An Snellinx Laura Bounti Yu-Chun Wang Ilie-Cosmin Stancu Nuno Apóstolo Kris Gevaert Ilse Dewachter Tara L Spires-Jones Bart De Strooper Joris De Wit Lujia Zhou Patrik Verstreken

Neuron 2018 02 1;97(4):823-835.e8. Epub 2018 Feb 1.

VIB-KU Leuven Center for Brain & Disease Research, 3000 Leuven, Belgium; Department of Neurosciences and Leuven Brain Institute, KU Leuven, 3000 Leuven, Belgium. Electronic address:

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February 2018

Tetraspanin 6: a pivotal protein of the multiple vesicular body determining exosome release and lysosomal degradation of amyloid precursor protein fragments.

Authors:
Francesc X Guix Ragna Sannerud Fedor Berditchevski Amaia M Arranz Katrien Horré An Snellinx Amantha Thathiah Takaomi Saido Takashi Saito Sundaresan Rajesh Michael Overduin Samir Kumar-Singh Enrico Radaelli Nikky Corthout Julien Colombelli Sébastien Tosi Sebastian Munck Isabel H Salas Wim Annaert Bart De Strooper

Mol Neurodegener 2017 03 10;12(1):25. Epub 2017 Mar 10.

VIB Center for Brain and Disease research - VIB, Leuven, Belgium.

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March 2017

Hallmarks of Alzheimer's Disease in Stem-Cell-Derived Human Neurons Transplanted into Mouse Brain.

Authors:
Ira Espuny-Camacho Amaia M Arranz Mark Fiers An Snellinx Kunie Ando Sebastian Munck Jerome Bonnefont Laurie Lambot Nikky Corthout Lorna Omodho Elke Vanden Eynden Enrico Radaelli Ina Tesseur Selina Wray Andreas Ebneth John Hardy Karelle Leroy Jean-Pierre Brion Pierre Vanderhaeghen Bart De Strooper

Neuron 2017 Mar 23;93(5):1066-1081.e8. Epub 2017 Feb 23.

VIB Center for Brain and Disease Research, VIB-Leuven, 3000 Leuven, Belgium; Center for Human Genetics, Universitaire ziekenhuizen and LIND, KU Leuven, 3000 Leuven, Belgium; Institute of Neurology and Dementia Research Institute, University College London, Queen Square, WC1N 3BG London, UK. Electronic address:

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March 2017

Loss of GPR3 reduces the amyloid plaque burden and improves memory in Alzheimer's disease mouse models.

Authors:
Yunhong Huang Aneta Skwarek-Maruszewska Katrien Horré Elke Vandewyer Leen Wolfs An Snellinx Takashi Saito Enrico Radaelli Nikky Corthout Julien Colombelli Adrian C Lo Leen Van Aerschot Zsuzsanna Callaerts-Vegh Daniah Trabzuni Koen Bossers Joost Verhaagen Mina Ryten Sebastian Munck Rudi D'Hooge Dick F Swaab John Hardy Takaomi C Saido Bart De Strooper Amantha Thathiah

Sci Transl Med 2015 Oct;7(309):309ra164

VIB Center for the Biology of Disease, 3000 Leuven, Belgium. KU Leuven Center for Human Genetics and Leuven Institute for Neurodegenerative Diseases, 3000 Leuven, Belgium.

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October 2015

The Alzheimer disease protective mutation A2T modulates kinetic and thermodynamic properties of amyloid-β (Aβ) aggregation.

Authors:
Iryna Benilova Rodrigo Gallardo Andreea-Alexandra Ungureanu Virginia Castillo Cano An Snellinx Meine Ramakers Carmen Bartic Frederic Rousseau Joost Schymkowitz Bart De Strooper

J Biol Chem 2014 Nov 24;289(45):30977-89. Epub 2014 Sep 24.

From the VIB Center for the Biology of Disease, the Center for Human Genetics and Leuven Institute for Neurodegenerative Diseases, University of Leuven,

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November 2014

Cell autonomous regulation of hippocampal circuitry via Aph1b-γ-secretase/neuregulin 1 signalling.

Authors:
Pietro Fazzari An Snellinx Victor Sabanov Tariq Ahmed Lutgarde Serneels Annette Gartner S Ali M Shariati Detlef Balschun Bart De Strooper

Elife 2014 Jun 2;3. Epub 2014 Jun 2.

VIB Center for the Biology of Disease, KU Leuven, Leuven, Belgium.

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June 2014

β-arrestin 2 regulates Aβ generation and γ-secretase activity in Alzheimer's disease.

Authors:
Amantha Thathiah Katrien Horré An Snellinx Elke Vandewyer Yunhong Huang Marta Ciesielska Gerdien De Kloe Sebastian Munck Bart De Strooper

Nat Med 2013 Jan 2;19(1):43-9. Epub 2012 Dec 2.

Vlaams Instituut voor Biotechnologie Center for the Biology of Disease, Leuven, Belgium.

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January 2013

LRRK2 expression is enriched in the striosomal compartment of mouse striatum.

Authors:
Wim Mandemakers An Snellinx Michael J O'Neill Bart de Strooper

Neurobiol Dis 2012 Dec 29;48(3):582-93. Epub 2012 Jul 29.

Center for Human Genetics, K. U. Leuven, Belgium.

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December 2012

Modification of γ-secretase by nitrosative stress links neuronal ageing to sporadic Alzheimer's disease.

Authors:
Francesc X Guix Tina Wahle Kristel Vennekens An Snellinx Lucía Chávez-Gutiérrez Gerard Ill-Raga Eva Ramos-Fernandez Cristina Guardia-Laguarta Alberto Lleó Muriel Arimon Oksana Berezovska Francisco J Muñoz Carlos G Dotti Bart De Strooper

EMBO Mol Med 2012 Jul 2;4(7):660-73. Epub 2012 May 2.

VIB Center for Biology of Disease - VIB, Leuven, Belgium.

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July 2012

The disintegrin/metalloproteinase ADAM10 is essential for the establishment of the brain cortex.

Authors:
Ellen Jorissen Johannes Prox Christian Bernreuther Silvio Weber Ralf Schwanbeck Lutgarde Serneels An Snellinx Katleen Craessaerts Amantha Thathiah Ina Tesseur Udo Bartsch Gisela Weskamp Carl P Blobel Markus Glatzel Bart De Strooper Paul Saftig

J Neurosci 2010 Apr;30(14):4833-44

Center for Human Genetics, Katholieke Universiteit Leuven, Vlaams Instituut voor Biotechnologie (VIB), 3000 Leuven, Belgium.

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April 2010

Parkinson's disease mutations in PINK1 result in decreased Complex I activity and deficient synaptic function.

Authors:
Vanessa A Morais Patrik Verstreken Anne Roethig Joél Smet An Snellinx Mieke Vanbrabant Dominik Haddad Christian Frezza Wim Mandemakers Daniela Vogt-Weisenhorn Rudy Van Coster Wolfgang Wurst Luca Scorrano Bart De Strooper

EMBO Mol Med 2009 May;1(2):99-111

Center for Human Genetics, K.U. Leuven, Leuven, Belgium.

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May 2009

ADAM10, the rate-limiting protease of regulated intramembrane proteolysis of Notch and other proteins, is processed by ADAMS-9, ADAMS-15, and the gamma-secretase.

Authors:
Thomas Tousseyn Amantha Thathiah Ellen Jorissen Tim Raemaekers Uwe Konietzko Karina Reiss Elke Maes An Snellinx Lutgarde Serneels Omar Nyabi Wim Annaert Paul Saftig Dieter Hartmann Bart De Strooper

J Biol Chem 2009 Apr 11;284(17):11738-47. Epub 2009 Feb 11.

Center for Human Genetics, Katholieke Universiteit Leuven (K. U. Leuven), Department for Developmental and Molecular Genetics, and Laboratory of Membrane Trafficking, Vlaams Instituut voor Biotechnologie (VIB), K. U. Leuven, B-3000 Leuven, Belgium.

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April 2009

Limited redundancy of the proprotein convertase furin in mouse liver.

Authors:
Anton J M Roebroek Neil A Taylor Els Louagie Ilse Pauli Liesbeth Smeijers An Snellinx Annick Lauwers Wim J M Van de Ven Dieter Hartmann John W M Creemers

J Biol Chem 2004 Dec 7;279(51):53442-50. Epub 2004 Oct 7.

Experimental Mouse Genetics, University of Leuven and Flanders Interuniversity Institute for Biotechnology, B-3000 Leuven, Belgium.

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December 2004

Partial loss of presenilins causes seborrheic keratosis and autoimmune disease in mice.

Authors:
Jos Tournoy Xavier Bossuyt An Snellinx Marleen Regent Marian Garmyn Lutgarde Serneels Paul Saftig Katleen Craessaerts Bart De Strooper Dieter Hartmann

Hum Mol Genet 2004 Jul 5;13(13):1321-31. Epub 2004 May 5.

Neuronal Cell Biology Laboratory, Center for Human Genetics CB 4, University Hospital, Catholic University of Leuven, Belgium.

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July 2004

CALL interrupted in a patient with non-specific mental retardation: gene dosage-dependent alteration of murine brain development and behavior.

Authors:
Suzanna G M Frints Peter Marynen Dieter Hartmann Jean-Pierre Fryns Jean Steyaert Melitta Schachner Bettina Rolf Katleen Craessaerts An Snellinx Karen Hollanders Rudi D'Hooge Peter P De Deyn Guy Froyen

Hum Mol Genet 2003 Jul;12(13):1463-74

Flanders Interuniversity Institute for Biotechnology (VIB), Center for Human Genetics, Leuven, Belgium.

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July 2003