Amy S Lee

Amy S Lee

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Amy S Lee

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Integration of a Comprehensive Contraception Education Program Into Clinical Practice in a Family Planning Clinic.

Nurs Womens Health 2019 Oct 26;23(5):414-423. Epub 2019 Aug 26.

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http://dx.doi.org/10.1016/j.nwh.2019.07.007DOI Listing
October 2019

A complex suite of loci and elements in eukaryotic type II topoisomerases determine selective sensitivity to distinct poisoning agents.

Nucleic Acids Res 2019 09;47(15):8163-8179

Johns Hopkins University School of Medicine, Department of Biophysics and Biophysical Chemistry, Baltimore, MD 21205, USA.

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http://dx.doi.org/10.1093/nar/gkz579DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6735899PMC
September 2019

The COOH-Terminal Proline-Rich Region of GRP78 Is a Key Regulator of Its Cell Surface Expression and Viability of Tamoxifen-Resistant Breast Cancer Cells.

Neoplasia 2019 08 12;21(8):837-848. Epub 2019 Jul 12.

Department of Biochemistry and Molecular Medicine, University of Southern California, 1441 Eastlake Avenue, Los Angeles, California 90089, USA; USC Norris Comprehensive Cancer Center, University of Southern California, 1441 Eastlake Avenue, Los Angeles, California 90089, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neo.2019.05.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6629921PMC
August 2019

GRP78 regulates CD44v membrane homeostasis and cell spreading in tamoxifen-resistant breast cancer.

Life Sci Alliance 2019 08 15;2(4). Epub 2019 Aug 15.

Department of Biochemistry and Molecular Medicine, University of Southern California, Los Angeles, CA, USA

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http://dx.doi.org/10.26508/lsa.201900377DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6696983PMC
August 2019

Improving Provider Readiness for Intimate Partner Violence Screening.

Worldviews Evid Based Nurs 2019 Jun 23;16(3):204-210. Epub 2019 Apr 23.

Johns Hopkins University School of Medicine, Baltimore, MD, USA.

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https://onlinelibrary.wiley.com/doi/abs/10.1111/wvn.12360
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http://dx.doi.org/10.1111/wvn.12360DOI Listing
June 2019

Modular Architecture of the STING C-Terminal Tail Allows Interferon and NF-κB Signaling Adaptation.

Cell Rep 2019 04;27(4):1165-1175.e5

Department of Microbiology, Harvard Medical School, Boston, MA 02115, USA; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA 02115, USA; Parker Institute for Cancer Immunotherapy at Dana-Farber Cancer Institute, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2019.03.098DOI Listing
April 2019

Intranasal Sufentanil Versus Intravenous Morphine for Acute Pain in the Emergency Department: A Randomized Pilot Trial.

J Emerg Med 2019 Mar 9;56(3):301-307. Epub 2019 Jan 9.

Department of Emergency Medicine, The Brooklyn Hospital Center, Brooklyn, New York.

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http://dx.doi.org/10.1016/j.jemermed.2018.12.002DOI Listing
March 2019

Glucose-regulated protein 78 is essential for cardiac myocyte survival.

Cell Death Differ 2018 12 17;25(12):2181-2194. Epub 2018 Apr 17.

Division of Cardiology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA.

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http://dx.doi.org/10.1038/s41418-018-0109-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6261960PMC
December 2018

Heterozygosity of Chaperone Grp78 Reduces Intestinal Stem Cell Regeneration Potential and Protects against Adenoma Formation.

Cancer Res 2018 11 19;78(21):6098-6106. Epub 2018 Sep 19.

Department of Gastroenterology and Hepatology, Tytgat Institute for Liver and Intestinal Research, University of Amsterdam, Amsterdam, the Netherlands.

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http://dx.doi.org/10.1158/0008-5472.CAN-17-3600DOI Listing
November 2018

Suppression of stress induction of the 78-kilodalton glucose regulated protein (GRP78) in cancer by IT-139, an anti-tumor ruthenium small molecule inhibitor.

Oncotarget 2018 Jul 3;9(51):29698-29714. Epub 2018 Jul 3.

Department of Biochemistry and Molecular Medicine, University of Southern California, Keck School of Medicine, USC Norris Comprehensive Cancer Center, Los Angeles 90089, CA, USA.

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http://dx.doi.org/10.18632/oncotarget.25679DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6049868PMC
July 2018

Endoplasmic reticulum stress activates SRC, relocating chaperones to the cell surface where GRP78/CD109 blocks TGF-β signaling.

Proc Natl Acad Sci U S A 2018 05 13;115(18):E4245-E4254. Epub 2018 Apr 13.

Department of Biochemistry and Molecular Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089;

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http://dx.doi.org/10.1073/pnas.1714866115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5939063PMC
May 2018

New role of endoplasmic reticulum chaperones in regulating metaplasia during tumorigenesis.

Mol Cell Oncol 2017 30;4(6):e1345350. Epub 2017 Jun 30.

Department of Biochemistry and Molecular Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.

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http://dx.doi.org/10.1080/23723556.2017.1345350DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5706948PMC
June 2017

GRP78 haploinsufficiency suppresses acinar-to-ductal metaplasia, signaling, and mutant -driven pancreatic tumorigenesis in mice.

Proc Natl Acad Sci U S A 2017 05 1;114(20):E4020-E4029. Epub 2017 May 1.

Department of Biochemistry and Molecular Biology, University of Southern California Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089-9176;

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http://dx.doi.org/10.1073/pnas.1616060114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5441757PMC
May 2017

The Endoplasmic Reticulum Chaperone GRP78/BiP Modulates Prion Propagation in vitro and in vivo.

Sci Rep 2017 03 23;7:44723. Epub 2017 Mar 23.

Mitchell Center for Alzheimer's Disease and Related Brain Disorders, Department of Neurology, University of Texas Houston Medical School, 6431 Fannin St, Houston, TX 77030, USA.

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http://dx.doi.org/10.1038/srep44723DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5363067PMC
March 2017

Effects of Prolonged GRP78 Haploinsufficiency on Organ Homeostasis, Behavior, Cancer and Chemotoxic Resistance in Aged Mice.

Sci Rep 2017 02 1;7:40919. Epub 2017 Feb 1.

Department of Pathology, University of Southern California Keck School of Medicine, USC Norris Comprehensive Cancer Center, 1441 Eastlake Avenue, Los Angeles, CA 90089-9176, United States.

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http://www.nature.com/articles/srep40919
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http://dx.doi.org/10.1038/srep40919DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5286507PMC
February 2017

Glucose-regulated protein 94 deficiency induces squamous cell metaplasia and suppresses PTEN-null driven endometrial epithelial tumor development.

Oncotarget 2016 Mar;7(12):14885-97

Department of Biochemistry and Molecular Biology, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089, USA.

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http://dx.doi.org/10.18632/oncotarget.7450DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4924759PMC
March 2016

GRP94 Regulates Circulating Cholesterol Levels through Blockade of PCSK9-Induced LDLR Degradation.

Cell Rep 2015 Dec 25;13(10):2064-71. Epub 2015 Nov 25.

Laboratory of Molecular Cell Biology, Montreal Heart Institute, Montréal, QC H1T 1C8, Canada; Department of Pharmacology, Faculty of Medicine, Université de Montréal, Montréal, QC H3C 3J7, Canada; Department of Medicine, Faculty of Medicine, Université de Montréal, Montréal, QC H3C 3J7, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2015.11.006DOI Listing
December 2015

Ancient Origin of cGAS-STING Reveals Mechanism of Universal 2',3' cGAMP Signaling.

Mol Cell 2015 Sep 20;59(6):891-903. Epub 2015 Aug 20.

Department of Molecular & Cell Biology, University of California, Berkeley, CA 94720, USA; Cancer Research Laboratory, University of California, Berkeley, CA 94720, USA; Howard Hughes Medical Institute (HHMI), University of California, Berkeley, CA 94720, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2015.07.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4575873PMC
September 2015

Role of the unfolded protein response, GRP78 and GRP94 in organ homeostasis.

J Cell Physiol 2015 Jul;230(7):1413-20

Department of Biochemistry and Molecular Biology, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California.

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http://dx.doi.org/10.1002/jcp.24923DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4725317PMC
July 2015

eIF3 targets cell-proliferation messenger RNAs for translational activation or repression.

Nature 2015 Jun 6;522(7554):111-4. Epub 2015 Apr 6.

1] Department of Molecular &Cell Biology, University of California, Berkeley, Berkeley, California 94720, USA [2] Center for RNA Systems Biology, University of California, Berkeley, Berkeley, California 94720, USA [3] Department of Chemistry, University of California, Berkeley, Berkeley, California 94720, USA [4] Physical Biosciences Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA.

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http://dx.doi.org/10.1038/nature14267DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4603833PMC
June 2015

Reply: To PMID 24027047.

Hepatology 2015 May 24;61(5):1767-8. Epub 2014 Dec 24.

Department of Biochemistry and Molecular Biology, University of Southern California, Keck School of Medicine, USC Norris Comprehensive Cancer Center, Los Angeles, CA.

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http://dx.doi.org/10.1002/hep.27405DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4723264PMC
May 2015

Characterization and mechanism of stress-induced translocation of 78-kilodalton glucose-regulated protein (GRP78) to the cell surface.

J Biol Chem 2015 Mar 11;290(13):8049-64. Epub 2015 Feb 11.

From the Department of Biochemistry and Molecular Biology, University of Southern California, Keck School of Medicine, USC Norris Comprehensive Cancer Center, Los Angeles, California 90089-9176 and

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http://dx.doi.org/10.1074/jbc.M114.618736DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4375463PMC
March 2015

Integrase-mediated spacer acquisition during CRISPR-Cas adaptive immunity.

Nature 2015 Mar 18;519(7542):193-8. Epub 2015 Feb 18.

1] Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, California 94720, USA [2] Center for RNA Systems Biology, University of California, Berkeley, Berkeley, California 94720, USA [3] Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, California 94720, USA [4] Department of Chemistry, University of California, Berkeley, Berkeley, California 94720, USA [5] Physical Biosciences Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA.

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http://rnajc.ucsf.edu/sites/rnajc.ucsf.edu/files/nature14237
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https://pdfs.semanticscholar.org/a807/1f835dbdea87a8bcf2f68c
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http://www.nature.com/doifinder/10.1038/nature14237
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4359072PMC
March 2015

ER stress induces epithelial differentiation in the mouse oesophagus.

Gut 2015 Feb 30;64(2):195-202. Epub 2014 Apr 30.

Tytgat Institute for Liver and Intestinal Research and Department of Gastroenterology & Hepatology, Academic Medical Center, Amsterdam, The Netherlands.

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http://gut.bmj.com/lookup/doi/10.1136/gutjnl-2013-306347
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http://dx.doi.org/10.1136/gutjnl-2013-306347DOI Listing
February 2015

A unified strategy for the synthesis of 7-membered-ring-containing Lycopodium alkaloids.

J Am Chem Soc 2014 Sep 12;136(38):13442-52. Epub 2014 Sep 12.

Department of Chemistry and Chemical Biology, Harvard University , Cambridge, Massachusetts 02138, United States.

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http://dx.doi.org/10.1021/ja507740uDOI Listing
September 2014

Cancer cells resistant to therapy promote cell surface relocalization of GRP78 which complexes with PI3K and enhances PI(3,4,5)P3 production.

PLoS One 2013 11;8(11):e80071. Epub 2013 Nov 11.

Department of Biochemistry and Molecular Biology, University of Southern California, Keck School of Medicine, USC Norris Comprehensive Cancer Center, Los Angeles, California, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0080071PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3823711PMC
August 2014

Structure-guided reprogramming of human cGAS dinucleotide linkage specificity.

Cell 2014 Aug 14;158(5):1011-1021. Epub 2014 Aug 14.

Department of Molecular & Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA; Center for RNA Systems Biology, University of California, Berkeley, Berkeley, CA 94720, USA; Howard Hughes Medical Institute (HHMI), University of California, Berkeley, Berkeley, CA 94720, USA; Department of Chemistry, University of California, Berkeley, Berkeley, CA 94720, USA; Physical Biosciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2014.07.028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4157622PMC
August 2014

Targeted deletion of ER chaperone GRP94 in the liver results in injury, repopulation of GRP94-positive hepatocytes, and spontaneous hepatocellular carcinoma development in aged mice.

Neoplasia 2014 Aug;16(8):617-26

Department of Biochemistry and Molecular Biology, University of Southern California, Keck School of Medicine, USC Norris Comprehensive Cancer Center, 1441 Eastlake Avenue, NOR 5308, Los Angeles, CA, 90089-9176, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neo.2014.07.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4235012PMC
August 2014

Differential requirement of GRP94 and GRP78 in mammary gland development.

Sci Rep 2014 Jun 23;4:5390. Epub 2014 Jun 23.

Department of Biochemistry and Molecular Biology, University of Southern California, Keck School of Medicine, USC Norris Comprehensive Cancer Center, Los Angeles, CA, USA.

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http://www.nature.com/articles/srep05390
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http://dx.doi.org/10.1038/srep05390DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4066247PMC
June 2014

Glucose-regulated proteins in cancer: molecular mechanisms and therapeutic potential.

Authors:
Amy S Lee

Nat Rev Cancer 2014 Apr;14(4):263-76

Department of Biochemistry and Molecular Biology, University of Southern California Norris Comprehensive Cancer Center, 1441 Eastlake Avenue, Room 5308, Los Angeles, California 900899176, USA.

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http://dx.doi.org/10.1038/nrc3701DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4158750PMC
April 2014

Liver-specific knockout of GRP94 in mice disrupts cell adhesion, activates liver progenitor cells, and accelerates liver tumorigenesis.

Hepatology 2014 Mar 27;59(3):947-57. Epub 2014 Jan 27.

Department of Biochemistry and Molecular Biology, University of Southern California, Keck School of Medicine, USC Norris Comprehensive Cancer Center, Los Angeles, CA.

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http://dx.doi.org/10.1002/hep.26711DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4214272PMC
March 2014

Deficiency of GRP94 in the hematopoietic system alters proliferation regulators in hematopoietic stem cells.

Stem Cells Dev 2013 Dec 20;22(23):3062-73. Epub 2013 Aug 20.

1 Department of Biochemistry and Molecular Biology, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California , Los Angeles, California.

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http://dx.doi.org/10.1089/scd.2013.0181DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3856911PMC
December 2013

Monoclonal antibody against cell surface GRP78 as a novel agent in suppressing PI3K/AKT signaling, tumor growth, and metastasis.

Clin Cancer Res 2013 Dec 18;19(24):6802-11. Epub 2013 Sep 18.

Authors' Affiliations: Departments of Pathology, Biochemistry and Molecular Biology, and Radiology; School of Pharmacy, University of Southern California Keck School of Medicine, USC Norris Comprehensive Cancer Center; and VasGene Therapeutics Inc., Los Angeles, California.

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http://dx.doi.org/10.1158/1078-0432.CCR-13-1106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4151476PMC
December 2013

AKT inhibition mitigates GRP78 (glucose-regulated protein) expression and contribution to chemoresistance in endometrial cancers.

Int J Cancer 2013 Jul 8;133(1):21-30. Epub 2013 Feb 8.

Women's Cancer Program, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, USA.

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http://dx.doi.org/10.1002/ijc.27994DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3633665PMC
July 2013

Synthesis of the C4-epi-lomaiviticin B core reveals subtle stereoelectronic effects.

Org Lett 2013 May 9;15(10):2390-3. Epub 2013 May 9.

Department of Chemistry and Chemical Biology, Harvard University , 12 Oxford Street, Cambridge, Massachusetts 02138, United States.

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http://dx.doi.org/10.1021/ol400832rDOI Listing
May 2013

GRP78 plays an essential role in adipogenesis and postnatal growth in mice.

FASEB J 2013 Mar 24;27(3):955-64. Epub 2012 Nov 24.

Department of Biochemistry and Molecular Biology, USC Norris Comprehensive Cancer Center, 1441 Eastlake Ave., Rm. 5308, Los Angeles, CA 90089-9176, USA.

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http://dx.doi.org/10.1096/fj.12-213330DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3574283PMC
March 2013

The effect of gynecologic algorithm pathways on emergency department visit times.

J Emerg Med 2013 Jan 1;44(1):217-24. Epub 2012 May 1.

Department of Gynecology and Obstetrics, Johns Hopkins Hospital, Baltimore, Maryland 21287, USA.

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http://dx.doi.org/10.1016/j.jemermed.2012.02.016DOI Listing
January 2013

Management of first-trimester complications in the emergency department.

Am J Health Syst Pharm 2013 Jan;70(2):99-111

Emergency Medicine, Department of Pharmacy, The Johns Hopkins Hospital, Baltimore, MD 21287, USA.

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http://dx.doi.org/10.2146/ajhp120069DOI Listing
January 2013

GRP78/BiP is a novel downstream target of IGF-1 receptor mediated signaling.

J Cell Physiol 2012 Dec;227(12):3803-11

Department of Biochemistry and Molecular Biology, University of Southern California, Norris Comprehensive Cancer Center, Keck School of Medicine of USC, Los Angeles, California 90089-9176, USA.

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http://dx.doi.org/10.1002/jcp.24090DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3421054PMC
December 2012

Acute inducible ablation of GRP78 reveals its role in hematopoietic stem cell survival, lymphogenesis and regulation of stress signaling.

PLoS One 2012 18;7(6):e39047. Epub 2012 Jun 18.

Department of Biochemistry and Molecular Biology, University of Southern California Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California, USA.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0039047PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3377598PMC
December 2012

Endoplasmic reticulum stress response promotes cytotoxic phenotype of CD8αβ+ intraepithelial lymphocytes in a mouse model for Crohn's disease-like ileitis.

J Immunol 2012 Aug 2;189(3):1510-20. Epub 2012 Jul 2.

Chair for Biofunctionality, Research Centre for Nutrition and Food Science, Centre for Diet and Disease, Technical University of Munich, 85350 Freising-Weihenstephan, Germany.

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http://dx.doi.org/10.4049/jimmunol.1200166DOI Listing
August 2012

A novel pathogenic role of the ER chaperone GRP78/BiP in rheumatoid arthritis.

J Exp Med 2012 Apr 19;209(4):871-86. Epub 2012 Mar 19.

Research Institute of Immunobiology, Catholic Research Institute of Medical Science, Catholic University of Korea, Seoul 137-701, South Korea.

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http://dx.doi.org/10.1084/jem.20111783DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3328363PMC
April 2012

Inducible knockout of GRP78/BiP in the hematopoietic system suppresses Pten-null leukemogenesis and AKT oncogenic signaling.

Blood 2012 Jan 21;119(3):817-25. Epub 2011 Sep 21.

Department of Biochemistry and Molecular Biology, University of Southern California Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, USA.

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http://dx.doi.org/10.1182/blood-2011-06-357384DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3265205PMC
January 2012

The endoplasmic reticulum chaperone protein GRP94 is required for maintaining hematopoietic stem cell interactions with the adult bone marrow niche.

PLoS One 2011 24;6(5):e20364. Epub 2011 May 24.

Department of Biochemistry and Molecular Biology and the USC Norris Comprehensive Cancer Center, University of Southern California Keck School of Medicine, Los Angeles, California, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0020364PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3101259PMC
September 2011

Soy food supplementation, dietary fat reduction and peripheral blood gene expression in postmenopausal women--a randomized, controlled trial.

Mol Nutr Food Res 2011 Sep 8;55 Suppl 2:S264-77. Epub 2011 Aug 8.

Department of Preventive Medicine, University of Southern California, Keck School of Medicine, Los Angeles, CA, USA.

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http://dx.doi.org/10.1002/mnfr.201100242DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3819223PMC
September 2011

Inositol 1,4,5-trisphosphate receptor 1 mutation perturbs glucose homeostasis and enhances susceptibility to diet-induced diabetes.

J Endocrinol 2011 Aug 12;210(2):209-17. Epub 2011 May 12.

Department of Biochemistry and Molecular Biology, USC Norris Comprehensive Cancer Center, University of Southern California Keck School of Medicine, 1441 Eastlake Avenue, Los Angeles, California 90089-9176, USA.

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http://dx.doi.org/10.1530/JOE-11-0012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3137733PMC
August 2011

Liver-specific loss of glucose-regulated protein 78 perturbs the unfolded protein response and exacerbates a spectrum of liver diseases in mice.

Hepatology 2011 Jul;54(1):229-39

Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.

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http://doi.wiley.com/10.1002/hep.24368
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http://dx.doi.org/10.1002/hep.24368DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3125405PMC
July 2011

Novel mechanism of anti-apoptotic function of 78-kDa glucose-regulated protein (GRP78): endocrine resistance factor in breast cancer, through release of B-cell lymphoma 2 (BCL-2) from BCL-2-interacting killer (BIK).

J Biol Chem 2011 Jul 26;286(29):25687-96. Epub 2011 May 26.

Department of Biochemistry and Molecular Biology, USC Norris Comprehensive Cancer Center, University of Southern California Keck School of Medicine, Los Angeles, California 90089-9176, USA.

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http://dx.doi.org/10.1074/jbc.M110.212944DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3138298PMC
July 2011

Impaired eyeblink conditioning in 78 kDa-glucose regulated protein (GRP78)/immunoglobulin binding protein (BiP) conditional knockout mice.

Behav Neurosci 2011 Jun;125(3):404-11

Neuroscience Program, University of Southern California, Los Angeles, CA 90089-2520, USA.

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http://dx.doi.org/10.1037/a0023185DOI Listing
June 2011

The critical role of GRP78 in physiologic and pathologic stress.

Curr Opin Cell Biol 2011 Apr 21;23(2):150-6. Epub 2010 Oct 21.

Department of Biochemistry and Molecular Biology, University of Southern California Keck School of Medicine, USC Norris Comprehensive Cancer Center, 1441 Eastlake Avenue, Los Angeles, CA 90089-9176, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S095506741000169
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http://dx.doi.org/10.1016/j.ceb.2010.09.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3043145PMC
April 2011

Measurement and modification of the expression level of the chaperone protein and signaling regulator GRP78/BiP in mammalian cells.

Methods Enzymol 2011 ;490:217-33

Department of Biochemistry and Molecular Biology, USC Norris Comprehensive Cancer Center, University of Southern California Keck School of Medicine, Los Angeles, California, USA.

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http://linkinghub.elsevier.com/retrieve/pii/B978012385114700
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http://dx.doi.org/10.1016/B978-0-12-385114-7.00013-1DOI Listing
April 2011

A critical role for GRP78/BiP in the tumor microenvironment for neovascularization during tumor growth and metastasis.

Cancer Res 2011 Apr 5;71(8):2848-57. Epub 2011 Apr 5.

Department of Biochemistry and Molecular Biology, USC Norris Comprehensive Cancer Center, University of Southern California Keck School of Medicine, Los Angeles, California 90089, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-10-3151DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3078191PMC
April 2011

Overexpressing GRP78 influences Ca2+ handling and function of mitochondria in astrocytes after ischemia-like stress.

Mitochondrion 2011 Mar 1;11(2):279-86. Epub 2010 Nov 1.

Department of Anesthesia, Stanford University School of Medicine, Stanford, CA 94305, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3037025PMC
March 2011

Beyond the endoplasmic reticulum: atypical GRP78 in cell viability, signalling and therapeutic targeting.

Biochem J 2011 Mar;434(2):181-8

Department of Biochemistry and Molecular Biology, University of Southern California Keck School of Medicine, USC Norris Comprehensive Cancer Center, 1441 Eastlake Avenue, Los Angeles, CA 90089-9176, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3353658PMC
March 2011

GRP78 as potential predictor for breast cancer response to adjuvant taxane therapy.

Int J Cancer 2011 Feb;128(3):726-31

Department of Preventive Medicine, USC/Norris Comprehensive Cancer Center, University of Southern California Keck School of Medicine, Los Angeles, CA 90089-9176, USA.

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http://dx.doi.org/10.1002/ijc.25370DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2972376PMC
February 2011

Grp78 heterozygosity regulates chaperone balance in exocrine pancreas with differential response to cerulein-induced acute pancreatitis.

Am J Pathol 2010 Dec 22;177(6):2827-36. Epub 2010 Oct 22.

Department of Biochemistry and Molecular Biology, University of Southern California Keck School of Medicine, USC Norris Comprehensive Cancer Center, 1441 Eastlake Avenue, Los Angeles, CA 90089-9176, USA.

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http://dx.doi.org/10.2353/ajpath.2010.100368DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2993313PMC
December 2010

Enantioselective synthesis of the lomaiviticin aglycon full carbon skeleton reveals remarkable remote substituent effects during the dimerization event.

Chemistry 2010 Nov;16(44):13058-62

Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, MA 02138, USA.

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http://doi.wiley.com/10.1002/chem.201002157
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3152949PMC
November 2010

The endothelial cell receptor GRP78 is required for mucormycosis pathogenesis in diabetic mice.

J Clin Invest 2010 Jun 17;120(6):1914-24. Epub 2010 May 17.

Division of Infectious Diseases, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, California 90502, USA.

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http://dx.doi.org/10.1172/JCI42164DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2877958PMC
June 2010

Cell surface relocalization of the endoplasmic reticulum chaperone and unfolded protein response regulator GRP78/BiP.

J Biol Chem 2010 May 5;285(20):15065-75. Epub 2010 Mar 5.

Departments of Biochemistry and Molecular Biology, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90089-9176, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M109.087445
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2865300PMC
May 2010

Targeted mutation of the mouse Grp94 gene disrupts development and perturbs endoplasmic reticulum stress signaling.

PLoS One 2010 May 26;5(5):e10852. Epub 2010 May 26.

Department of Biochemistry and Molecular Biology, University of Southern California Norris Comprehensive Cancer Center, University of Southern California Keck School of Medicine, Los Angeles, California, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2877114PMC
May 2010

Grp78 heterozygosity promotes adaptive unfolded protein response and attenuates diet-induced obesity and insulin resistance.

Diabetes 2010 Jan 6;59(1):6-16. Epub 2009 Oct 6.

Department of Biochemistry and Molecular Biology, University of Southern California/Norris Comprehensive Cancer Center, University of Southern California Keck School of Medicine, Los Angeles, California, USA.

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http://diabetes.diabetesjournals.org/cgi/doi/10.2337/db09-07
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2797945PMC
January 2010

The Par-4-GRP78 TRAIL, more twists and turns.

Authors:
Amy S Lee

Cancer Biol Ther 2009 Nov 20;8(22):2103-5. Epub 2009 Nov 20.

Department of Biochemistry and Molecular Biology, USC/Norris Comprehensive Cancer Center, University of Southern California Keck School of Medicine, Los Angeles, CA, USA.

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http://dx.doi.org/10.4161/cbt.8.22.10140DOI Listing
November 2009

Role of the unfolded protein response regulator GRP78/BiP in development, cancer, and neurological disorders.

Antioxid Redox Signal 2009 Sep;11(9):2307-16

Department of Biochemistry and Molecular Biology, University of Southern California Keck School of Medicine, USC/Norris Comprehensive Cancer Center, Los Angeles, California 90089-9176, USA.

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http://www.liebertpub.com/doi/10.1089/ars.2009.2485
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2819800PMC
September 2009

Regulation of PERK signaling and leukemic cell survival by a novel cytosolic isoform of the UPR regulator GRP78/BiP.

PLoS One 2009 Aug 31;4(8):e6868. Epub 2009 Aug 31.

Department of Biochemistry and Molecular Biology and the USC/Norris Comprehensive Cancer Center, University of Southern California Keck School of Medicine, Los Angeles, California, United States of America.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2729930PMC
August 2009

Transcriptional induction of GRP78/BiP by histone deacetylase inhibitors and resistance to histone deacetylase inhibitor-induced apoptosis.

Mol Cancer Ther 2009 May 5;8(5):1086-94. Epub 2009 May 5.

Department of Biochemistry and Molecular Biology, USC/Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90089-9176, USA.

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http://dx.doi.org/10.1158/1535-7163.MCT-08-1166DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2889001PMC
May 2009

Pten null prostate tumorigenesis and AKT activation are blocked by targeted knockout of ER chaperone GRP78/BiP in prostate epithelium.

Proc Natl Acad Sci U S A 2008 Dec 25;105(49):19444-9. Epub 2008 Nov 25.

Department of Biochemistry, University of Southern California Keck School of Medicine, University of Southern California/Norris Comprehensive Cancer Center, 1441 Eastlake Avenue, Los Angeles, CA 90089-9176, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2614780PMC
December 2008

Pronounced steric effects of substituents in the nazarov cyclization of aryl dienyl ketones.

Angew Chem Int Ed Engl 2008 ;47(34):6379-83

Department of Chemistry, University of California, Berkeley, Berkeley, CA 94720, USA.

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September 2008

Stress chaperone GRP78/BiP confers chemoresistance to tumor-associated endothelial cells.

Mol Cancer Res 2008 Aug;6(8):1268-75

Department of Biochemistry and Molecular Biology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089-9176, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2593417PMC
August 2008

Receptor determinants of zoonotic transmission of New World hemorrhagic fever arenaviruses.

Proc Natl Acad Sci U S A 2008 Feb 11;105(7):2664-9. Epub 2008 Feb 11.

Department of Microbiology and Molecular Genetics and New England Primate Research Center, Harvard Medical School, Southborough, MA 01772, USA.

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http://dx.doi.org/10.1073/pnas.0709254105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2268193PMC
February 2008

Critical role of the stress chaperone GRP78/BiP in tumor proliferation, survival, and tumor angiogenesis in transgene-induced mammary tumor development.

Cancer Res 2008 Jan;68(2):498-505

Department of Biochemistry and Molecular Biology, University of Southern California/Norris Comprehensive Cancer Center, Keck School of Medicine, Los Angeles, California 90089-9176, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-07-2950DOI Listing
January 2008

Endoplasmic reticulum stress.

Ann N Y Acad Sci 2007 Oct 4;1113:58-71. Epub 2007 May 4.

Institute of Medical Chemistry, Molecular Biology and Pathobiochemistry, Semmelweis University, Puskin utca 9, 1088, Budapest, Hungary.

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October 2007

Glucose-regulated protein GRP78 is up-regulated in prostate cancer and correlates with recurrence and survival.

Hum Pathol 2007 Oct 19;38(10):1547-52. Epub 2007 Jul 19.

Section of Urologic Oncology, Division of Urology, Oregon Health & Science University, Portland, OR 97239, USA.

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October 2007

The unfolded protein response regulator GRP78/BiP as a novel target for increasing chemosensitivity in malignant gliomas.

Cancer Res 2007 Oct;67(20):9809-16

Department of Pathology, and University of Southern California/Norris Comprehensive Cancer Center, University of Southern California Keck School of Medicine, Los Angeles, California 90033, USA.

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October 2007

ER chaperones in mammalian development and human diseases.

Authors:
Min Ni Amy S Lee

FEBS Lett 2007 Jul 25;581(19):3641-51. Epub 2007 Apr 25.

Department of Biochemistry and Molecular Biology, USC/Norris Comprehensive Cancer Center, Keck School of Medicine of the University of Southern California, 1441 Eastlake Ave., Los Angeles, CA 90089-9176, United States.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2040386PMC
July 2007

GRP78 induction in cancer: therapeutic and prognostic implications.

Authors:
Amy S Lee

Cancer Res 2007 Apr;67(8):3496-9

Department of Biochemistry and Molecular Biology, University of Southern California/Norris Comprehensive Cancer Center, University of Southern California Keck School of Medicine, 1441 Eastlake Avenue, Los Angeles, CA 90089, USA.

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April 2007

GRP78/BiP inhibits endoplasmic reticulum BIK and protects human breast cancer cells against estrogen starvation-induced apoptosis.

Cancer Res 2007 Apr;67(8):3734-40

Department of Biochemistry and Molecular Biology, USC/Norris Comprehensive Cancer Center, University of Southern California Keck School of Medicine, 1441 Eastlake Avenue, Los Angeles, CA 90089, USA.

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April 2007

Expression of stress response protein Grp78 is associated with the development of castration-resistant prostate cancer.

Clin Cancer Res 2006 Oct;12(20 Pt 1):5987-93

Department of Pathology, University of Southern California, Keck School of Medicine/USC Norris Comprehensive Cancer Center, Los Angeles, CA 90033, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-06-0133DOI Listing
October 2006

Constitutive nucleosome depletion and ordered factor assembly at the GRP78 promoter revealed by single molecule footprinting.

PLoS Genet 2006 Sep;2(9):e160

Department of Urology, USC/Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.0020160DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1574359PMC
September 2006

GRP78/BiP is required for cell proliferation and protecting the inner cell mass from apoptosis during early mouse embryonic development.

Mol Cell Biol 2006 Aug;26(15):5688-97

Department of Biochemistry and Molecular Biology and the USC/Norris Comprehensive Cancer Center, Keck School of Medicine of the University of Southern California, Los Angeles, CA 90089-9176, USA.

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http://dx.doi.org/10.1128/MCB.00779-06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1592753PMC
August 2006

GRP78 as a novel predictor of responsiveness to chemotherapy in breast cancer.

Cancer Res 2006 Aug;66(16):7849-53

Department of Preventive Medicine, University of Southern California/Norris Comprehensive Cancer Center, University of Southern California Keck School of Medicine, Los Angeles, CA 90089-9176, USA.

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http://cancerres.aacrjournals.org/lookup/doi/10.1158/0008-54
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August 2006

Glucose regulated proteins in cancer progression, drug resistance and immunotherapy.

Authors:
Yong Fu Amy S Lee

Cancer Biol Ther 2006 Jul 1;5(7):741-4. Epub 2006 Jul 1.

Department of Biochemistry and Molecular Biology, USC/Norris Comprehensive Cancer Center, University of Southern California Keck School of Medicine, Los Angeles, CA 90089-9176, USA.

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http://dx.doi.org/10.4161/cbt.5.7.2970DOI Listing
July 2006

ER stress and cancer.

Cancer Biol Ther 2006 Jul 1;5(7):721-2. Epub 2006 Jul 1.

Department of Biochemistry and Molecular Biology, USC/Norris Comprehensive Cancer Center, University of Southern California Keck School of Medicine, Los Angeles, CA 90089-9176, USA.

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http://dx.doi.org/10.4161/cbt.5.7.3120DOI Listing
July 2006

Activator protein-2 overexpression accounts for increased insulin receptor expression in human breast cancer.

Cancer Res 2006 May;66(10):5085-93

Dipartimento di Medicina Sperimentale e Clinica G. Salvatore, Università di Catanzaro Magna Graecia, Catanzaro, Italy.

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http://dx.doi.org/10.1158/0008-5472.CAN-05-3678DOI Listing
May 2006

Endoplasmic reticulum stress-induced apoptosis: multiple pathways and activation of p53-up-regulated modulator of apoptosis (PUMA) and NOXA by p53.

J Biol Chem 2006 Mar 6;281(11):7260-70. Epub 2006 Jan 6.

Department of Biochemistry and Molecular Biology, USC/Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, 1441 Eastlake Avenue, Los Angeles, CA 90089-9176, USA.

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http://dx.doi.org/10.1074/jbc.M509868200DOI Listing
March 2006

In vivo regulation of Grp78/BiP transcription in the embryonic heart: role of the endoplasmic reticulum stress response element and GATA-4.

J Biol Chem 2006 Mar 1;281(13):8877-87. Epub 2006 Feb 1.

Department of Biochemistry and Molecular Biology, University of Southern California/Norris Comprehensive Cancer Center, Los Angeles, CA 90089-9176, USA.

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http://dx.doi.org/10.1074/jbc.M505784200DOI Listing
March 2006

Stress induction of GRP78/BiP and its role in cancer.

Authors:
Jianze Li Amy S Lee

Curr Mol Med 2006 Feb;6(1):45-54

Department of Biochemistry and Molecular Biology, USC/Norris Comprehensive Cancer Center, University of Southern California Keck School of Medicine, Los Angeles, 90089-9176, USA.

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February 2006

Vascular targeting and antiangiogenesis agents induce drug resistance effector GRP78 within the tumor microenvironment.

Cancer Res 2005 Jul;65(13):5785-91

Department of Biochemistry and Molecular Biology, University of Southern California Keck School of Medicine, Los Angeles, California 90089-9176, USA.

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July 2005

Endoplasmic reticulum stress induction of the Grp78/BiP promoter: activating mechanisms mediated by YY1 and its interactive chromatin modifiers.

Mol Cell Biol 2005 Jun;25(11):4529-40

Department of Biochemistry and Molecular Biology, USC/Norris Comprehensive Cancer Center, Keck School of Medicine, 1441 Eastlake Ave., Room 5308, MC-9176, Los Angeles, CA 90089-9176, USA.

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http://mcb.asm.org/cgi/doi/10.1128/MCB.25.11.4529-4540.2005
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1140640PMC
June 2005

The ER chaperone and signaling regulator GRP78/BiP as a monitor of endoplasmic reticulum stress.

Authors:
Amy S Lee

Methods 2005 Apr;35(4):373-81

Department of Biochemistry and Molecular Biology and the USC/Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089-9176, USA.

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http://dx.doi.org/10.1016/j.ymeth.2004.10.010DOI Listing
April 2005