Amy Klion

Amy Klion

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Amy Klion

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Siglec-7 on peripheral blood eosinophils: Surface expression and function.

Allergy 2019 Jul 26;74(7):1257-1265. Epub 2019 Feb 26.

Pharmacology and Experimental Therapeutics Unit, School of Pharmacy, Institute for Drug Research, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel.

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http://doi.wiley.com/10.1111/all.13730
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http://dx.doi.org/10.1111/all.13730DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6661208PMC
July 2019

Benralizumab for -Negative Hypereosinophilic Syndrome.

N Engl J Med 2019 04;380(14):1336-1346

From the Laboratory of Parasitic Diseases (F.L.K., F.L., M.M., J.W., L.W., T.B., T.M., B.P., P.Y., P.K., A.D.K.) and Biostatistics Research Branch (M.P.F.), National Institute of Allergy and Infectious Diseases, the Digestive Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases (H.A., S.K.), and the Laboratory of Pathology, National Cancer Institute (A.P., M.Q.), National Institutes of Health (NIH), and the Departments of Laboratory Medicine (J.H.E., X.S., I.M.) and Transfusion Medicine (S.R.P.), NIH Clinical Center, Bethesda, Washington Adventist Hospital, Takoma Park (T.M.), and MedImmune (N.L., R.K.) and AstraZeneca (P.N., M.G.), Gaithersburg - all in Maryland; the Department of Veteran Affairs, Tennessee Valley Healthcare System, Chattanooga (J.H.E.); and MedImmune, South San Francisco, CA (L.Y.).

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http://dx.doi.org/10.1056/NEJMoa1812185DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6557265PMC
April 2019

Expansion of the Human Phenotype Ontology (HPO) knowledge base and resources.

Nucleic Acids Res 2019 Jan;47(D1):D1018-D1027

Monarch Initiative, monarchinitiative.org.

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https://academic.oup.com/nar/advance-article/doi/10.1093/nar
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http://dx.doi.org/10.1093/nar/gky1105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6324074PMC
January 2019

Transcript- and protein-level analyses of the response of human eosinophils to glucocorticoids.

Sci Data 2018 12 4;5:180275. Epub 2018 Dec 4.

Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 4 Memorial Drive, Building 4, Room 138, Bethesda, MD 20892, USA.

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http://www.nature.com/articles/sdata2018275
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http://dx.doi.org/10.1038/sdata.2018.275DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6278693PMC
December 2018

Hypereosinophilic syndrome: approach to treatment in the era of precision medicine.

Authors:
Amy Klion

Hematology Am Soc Hematol Educ Program 2018 11;2018(1):326-331

Human Eosinophil Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD.

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http://dx.doi.org/10.1182/asheducation-2018.1.326DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6245960PMC
November 2018

Biologic Agents for the Treatment of Hypereosinophilic Syndromes.

J Allergy Clin Immunol Pract 2017 Nov - Dec;5(6):1502-1509

Human Eosinophil Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, Md. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22132198173060
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http://dx.doi.org/10.1016/j.jaip.2017.08.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5718167PMC
June 2018

Swiss cheese heart.

Eur Heart J 2018 01;39(3):255-256

Advanced Cardiovascular Imaging Laboratory, National Heart, Lung, and Blood Institute, National Institutes of Health, 10 Center Dr, Building 10, Room B1D416, Bethesda, MD 20892-1061, USA.

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http://dx.doi.org/10.1093/eurheartj/ehx626DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5837325PMC
January 2018

Clinical and Biological Markers in Hypereosinophilic Syndromes.

Front Med (Lausanne) 2017 22;4:240. Epub 2017 Dec 22.

Human Eosinophil Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States.

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http://dx.doi.org/10.3389/fmed.2017.00240DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5743906PMC
December 2017

Surgical management of adult endocardial fibroelastosis.

J Thorac Cardiovasc Surg 2017 11 23;154(5):e81-e84. Epub 2017 May 23.

Cardiothoracic Surgery Research Program, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Md. Electronic address:

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http://dx.doi.org/10.1016/j.jtcvs.2017.05.050DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341226PMC
November 2017

A Test-and-Not-Treat Strategy for Onchocerciasis in Loa loa-Endemic Areas.

N Engl J Med 2017 11 8;377(21):2044-2052. Epub 2017 Nov 8.

From the Center for Research on Filariasis and other Tropical Diseases (J.K., H.C.N.-D., R.G.-K., G.-R.N., P.N., J.B.T.-M.) and the Faculty of Medicine and Biomedical Sciences, University of Yaounde I (J.K.), Yaounde, and the Faculty of Health Sciences, Department of Microbiology and Parasitology, University of Buea, and Research Foundation for Tropical Diseases and Environment (REFOTDE), Buea (S.W.) - all in Cameroon; Institut de Recherche pour le Développement Unité Mixte Internationale 233-INSERM Unité 1175, Montpellier University, Montpellier, France (S.D.P., C.B.C., M.B.); the Department of Bioengineering and the Biophysics Program, University of California, Berkeley, Berkeley (M.H.B., M.V.D., D.A.F.); the Department of Pathobiology and Diagnostic Investigation, Michigan State University, East Lansing (C.D.M.); the Department of Public Health, Erasmus MC, University Medical Center, Rotterdam, the Netherlands (W.A.S.); the Chan Zuckerberg Biohub, San Francisco (D.A.F.); and the Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD (A.D.K., T.B.N.).

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http://dx.doi.org/10.1056/NEJMoa1705026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5629452PMC
November 2017

Hypereosinophilia in Children and Adults: A Retrospective Comparison.

J Allergy Clin Immunol Pract 2016 Sep-Oct;4(5):941-947.e1. Epub 2016 Apr 27.

Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md. Electronic address:

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http://dx.doi.org/10.1016/j.jaip.2016.03.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5010485PMC
October 2017

Recent advances in understanding eosinophil biology.

Authors:
Amy Klion

F1000Res 2017 7;6:1084. Epub 2017 Jul 7.

Human Eosinophil Section, Laboratory of Parasitic Diseases, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.

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http://dx.doi.org/10.12688/f1000research.11133.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5506535PMC
July 2017

Hypereosinophilic Syndrome Subtype Predicts Responsiveness to Glucocorticoids.

J Allergy Clin Immunol Pract 2018 Jan - Feb;6(1):190-195. Epub 2017 Jul 27.

Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health, Bethesda, Md.

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http://dx.doi.org/10.1016/j.jaip.2017.06.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5760470PMC
July 2017

Mepolizumab or Placebo for Eosinophilic Granulomatosis with Polyangiitis.

N Engl J Med 2017 05;376(20):1921-1932

From the Department of Medicine, National Jewish Health, Denver (M.E.W.); the Division of Pulmonary, Critical Care, and Sleep Medicine, University of California San Diego, La Jolla (P.A.); Beth Israel Deaconess Medical Center, Boston (P.A., P.F.W.); the Department of Medicine, University of Cambridge, Cambridge (D.J.), the Department of Orthopaedics, Rheumatology, and Musculoskeletal Sciences, Botnar Research Centre, University of Oxford, Oxford (R.L.), Research and Development, Immuno-Inflammation Therapy Area Unit (J.B.), and Research and Development, Statistics, Programming, and Data Standards (S.M.), GlaxoSmithKline, Uxbridge, and Trizell, Oxford (R.P.) - all in the United Kingdom; the Human Eosinophil Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD (P.K., A.K.); the Center for Vasculitis Care and Research, Cleveland Clinic, Cleveland (C.A.L.); the Division of Rheumatology and the Department of Biostatistics and Clinical Epidemiology, University of Pennsylvania (P.A.M.), and the Respiratory Therapy Area Unit and Flexible Discovery Unit, GlaxoSmithKline (J.S.), Philadelphia; Rheumazentrum, Schleswig-Holstein Mitte, Neumünster, Germany (F.M.); the Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, MN (U.S.); the Vasculitis Research Unit, Department of Autoimmune Diseases, Hospital Clinic University of Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Barcelona (M.C.C.); the Respiratory Therapeutic Area, GlaxoSmithKline, Research Triangle Park, NC (S.W.Y.); and the Departments of Dermatology and Medicine, University of Utah School of Medicine, Salt Lake City (G.J.G.).

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http://dx.doi.org/10.1056/NEJMoa1702079DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5548295PMC
May 2017

Positivity of Antigen Tests Used for Diagnosis of Lymphatic Filariasis in Individuals Without Wuchereria bancrofti Infection But with High Loa loa Microfilaremia.

Am J Trop Med Hyg 2016 Dec 10;95(6):1417-1423. Epub 2016 Oct 10.

Unité Mixte Internationale 233, Institut de Recherche pour le Développement, Université de Montpellier, Institut National de la Santé et de la Recherche Médicale, Montpellier, France.

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http://dx.doi.org/10.4269/ajtmh.16-0547DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5154460PMC
December 2016

Eosinophilia: a pragmatic approach to diagnosis and treatment.

Authors:
Amy D Klion

Hematology Am Soc Hematol Educ Program 2015 ;2015:92-7

Human Eosinophil Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD.

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http://dx.doi.org/10.1182/asheducation-2015.1.92DOI Listing
October 2016

Biologic therapies targeting eosinophils: current status and future prospects.

J Allergy Clin Immunol Pract 2015 Mar-Apr;3(2):167-74

Human Eosinophil Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda. Electronic address:

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http://dx.doi.org/10.1016/j.jaip.2015.01.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4418449PMC
December 2015

Hypereosinophilic disorders.

J Allergy Clin Immunol Pract 2015 Mar-Apr;3(2):304-5; quiz 306

Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md.

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http://dx.doi.org/10.1016/j.jaip.2014.09.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4363101PMC
December 2015

Novel targeted therapies for eosinophil-associated diseases and allergy.

Annu Rev Pharmacol Toxicol 2015 17;55:633-56. Epub 2014 Oct 17.

Institute of Pharmacology, University of Bern, CH-3010 Bern, Switzerland; email:

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http://dx.doi.org/10.1146/annurev-pharmtox-010814-124407DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4924608PMC
September 2015

How I treat hypereosinophilic syndromes.

Authors:
Amy D Klion

Blood 2015 Aug 11;126(9):1069-77. Epub 2015 May 11.

Human Eosinophil Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD.

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http://www.bloodjournal.org/content/114/18/3736.full.pdf
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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2014-11-55
Publisher Site
http://dx.doi.org/10.1182/blood-2014-11-551614DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4551360PMC
August 2015

The Impact of Six Annual Rounds of Mass Drug Administration on Wuchereria bancrofti Infections in Humans and in Mosquitoes in Mali.

Am J Trop Med Hyg 2015 Aug 1;93(2):356-60. Epub 2015 Jun 1.

International Center of Excellence in Research (ICER-Mali), Filariasis Research and Training Unit, Bamako, Mali; University of Liverpool, Liverpool Liverpool School of Tropical Medicine, Centre for Neglected Tropical Diseases, Liverpool, United Kingdom; University of Liverpool, Liverpool Liverpool School of Tropical Medicine, Centre for Neglected Tropical Diseases, Liverpool, United Kingdom; National Institutes of Health, Laboratory of Parasitic Diseases, Helminth Immunology Section, Bethesda, Maryland; National Institutes of Health, Laboratory of Parasitic Diseases, Eosinophil Pathology Section, Bethesda, Maryland; World Health Organization, Vectors, Environment and Society Research, Geneva, Switzerland.

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http://dx.doi.org/10.4269/ajtmh.14-0516DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4530761PMC
August 2015

Eosinophil-Associated Disorders. Preface.

Immunol Allergy Clin North Am 2015 Aug;35(3):xi-xii

Section of Allergy & Immunology, Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Wexner Medical Center at the Ohio State University, Columbus, OH 43210, USA. Electronic address:

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http://dx.doi.org/10.1016/j.iac.2015.06.001DOI Listing
August 2015

Analysis of nematode motion using an improved light-scatter based system.

PLoS Negl Trop Dis 2015 Feb 19;9(2):e0003523. Epub 2015 Feb 19.

Department of Biological Sciences, Western Michigan University, Kalamazoo, Michigan, United States of America; Department of Pathobiology and Diagnostic Investigation, Michigan State University, East Lansing, Michigan, United States of America.

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http://dx.doi.org/10.1371/journal.pntd.0003523DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4335050PMC
February 2015

Eosinophil-associated processes underlie differences in clinical presentation of loiasis between temporary residents and those indigenous to Loa-endemic areas.

Clin Infect Dis 2015 Jan 18;60(1):55-63. Epub 2014 Sep 18.

Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland.

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http://dx.doi.org/10.1093/cid/ciu723DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4296126PMC
January 2015

Development of a suspension array assay in multiplex for the simultaneous measurement of serum levels of four eosinophil granule proteins.

J Immunol Methods 2014 Sep 8;411:11-22. Epub 2014 Jun 8.

Eosinophil Pathology Unit, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States.

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http://dx.doi.org/10.1016/j.jim.2014.05.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4171350PMC
September 2014

Eosinophils in vasculitis: characteristics and roles in pathogenesis.

Nat Rev Rheumatol 2014 Aug 8;10(8):474-83. Epub 2014 Jul 8.

Laboratory of Parasitic Diseases, National Institutes of Allergic and Infectious Diseases, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1038/nrrheum.2014.98DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4849122PMC
August 2014

Highly heterogeneous, activated, and short-lived regulatory T cells during chronic filarial infection.

Eur J Immunol 2014 Jul 22;44(7):2036-47. Epub 2014 May 22.

Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.

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http://dx.doi.org/10.1002/eji.201444452DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4809647PMC
July 2014

Rapid development of migratory, linear, and serpiginous lesions in association with immunosuppression.

J Am Acad Dermatol 2014 Jun;70(6):1130-4

DNA Repair Section, Dermatology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01909622130129
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http://dx.doi.org/10.1016/j.jaad.2013.11.036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4024165PMC
June 2014

Marked and persistent eosinophilia in the absence of clinical manifestations.

J Allergy Clin Immunol 2014 Apr 26;133(4):1195-202. Epub 2013 Aug 26.

Eosinophil Pathology Unit, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Frederick, Md. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2013.06.037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3935986PMC
April 2014

Reply: To PMID 23987798.

Authors:
Amy D Klion

J Allergy Clin Immunol 2014 Mar 16;133(3):933. Epub 2014 Jan 16.

Eosinophil Pathology Unit, Laboratory of Parasitic Diseases, National Institutes of Health, Bethesda, Md. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2013.12.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4158821PMC
March 2014

Long-term safety of mepolizumab for the treatment of hypereosinophilic syndromes.

J Allergy Clin Immunol 2013 Feb 4;131(2):461-7.e1-5. Epub 2012 Oct 4.

Department of Internal Medicine, Hôpital Erasme, Institute for Medical Immunology, Université Libre de Bruxelles, Gosselies, Belgium.

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http://dx.doi.org/10.1016/j.jaci.2012.07.055DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3558744PMC
February 2013

Peripheral blood stem cell transplant-related Plasmodium falciparum infection in a patient with sickle cell disease.

Transfusion 2012 Dec 27;52(12):2677-82. Epub 2012 Apr 27.

National Institute of Allergy and Infectious Diseases, Department of Transfusion Medicine, National Institutes of Health, Bethesda, Maryland, USA.

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http://dx.doi.org/10.1111/j.1537-2995.2012.03673.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3408807PMC
December 2012

ICON: Eosinophil Disorders.

World Allergy Organ J 2012 Dec;5(12):174-81

1Department of Medicine I, Division of Hematology & Hemostaseology, Medical University of Vienna, Austria 2Eosinophil Pathology Unit, Laboratory of Parasitic Diseases, NIH/NIAID, Bethesda, MD 3Children's Mercy Hospital, Kansas City, MO 4LBPA CNRS UMR8113, Ecole Normale Supérieure de Cachan, Cachan, France 5Department of Medicine, Division of Allergy and Clinical Immunology, Johns Hopkins University School of Medicine, Baltimore, MD 6Division of Allergic Diseases, Mayo Clinic, Rochester, MN 7Division of Hematology, Stanford Cancer Center, Stanford, CA 8MLL Münchner Leukämielabor, Munich, Germany 9Department of Hematology, Medical University School of Gdansk, Gdańsk, Poland 10Institute of Pathology, Ludwig-Maximilians-University, Munich, Germany 11Department of Dermatology, University of Utah Health Sciences Center, Salt Lake City, UT 12III. Medizinische Klinik, Universitätsmedizin Mannheim, Universität Heidelberg, Mannheim, Germany 13Department of Allergy and Immunology, National Research Institute for Children's Health and Development, Tokyo, Japan 14Department of Internal Medicine, Erasme Hospital, Université Libre de Bruxelles, Brussels, Belgium 15Division of Allergy and Immunology, Cincinnati Children's Hospital, Medical Center, Cincinnati, OH 16Institute of Pharmacology, University of Bern, Bern, Switzerland 17Center for Human Genetics, University Hospitals Leuven and Katholieke Universiteit Leuven, Leuven, Belgium 18Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 19Department of Medicine, University of Utah Health Sciences Center, Salt Lake City, UT.

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http://dx.doi.org/10.1097/WOX.0b013e31827f4192DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3651188PMC
December 2012

Biomarkers of eosinophil involvement in allergic and eosinophilic diseases: review of phenotypic and serum markers including a novel assay to quantify levels of soluble Siglec-8.

J Immunol Methods 2012 Sep 6;383(1-2):39-46. Epub 2012 Jun 6.

Department of Medicine, Division of Allergy and Clinical Immunology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

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http://dx.doi.org/10.1016/j.jim.2012.05.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3411856PMC
September 2012

Workshop report from the National Institutes of Health Taskforce on the Research Needs of Eosinophil-Associated Diseases (TREAD).

J Allergy Clin Immunol 2012 Sep;130(3):587-96

Cosner Scholar in Translational Research, Division of Allergy and Clinical Immunology, Johns Hopkins Asthma and Allergy Center, 5501 Hopkins Bayview Circle, Baltimore, MD 21224-6821, USA.

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http://dx.doi.org/10.1016/j.jaci.2012.07.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3432981PMC
September 2012

Eosinophilic myeloproliferative disorders.

Authors:
Amy D Klion

Hematology Am Soc Hematol Educ Program 2011 ;2011:257-63

National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1182/asheducation-2011.1.257DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4091807PMC
April 2012

Eosinophilia: introduction.

Authors:
Amy D Klion

Semin Hematol 2012 Apr;49(2):111-2

Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4113561PMC
http://dx.doi.org/10.1053/j.seminhematol.2012.01.004DOI Listing
April 2012

Therapeutic approaches to patients with hypereosinophilic syndromes.

Semin Hematol 2012 Apr;49(2):160-70

Institute of Pharmacology, University of Bern, Bern, Switzerland.

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http://dx.doi.org/10.1053/j.seminhematol.2012.01.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3314228PMC
April 2012

Interferon regulatory factor modulation underlies the bystander suppression of malaria antigen-driven IL-12 and IFN-γ in filaria-malaria co-infection.

Eur J Immunol 2012 Mar 19;42(3):641-50. Epub 2012 Jan 19.

Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

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http://doi.wiley.com/10.1002/eji.201141991
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http://dx.doi.org/10.1002/eji.201141991DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3430845PMC
March 2012

IL-5 receptor α levels in patients with marked eosinophilia or mastocytosis.

J Allergy Clin Immunol 2011 Nov 16;128(5):1086-92.e1-3. Epub 2011 Jul 16.

Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md.

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http://dx.doi.org/10.1016/j.jaci.2011.05.032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3205313PMC
November 2011

Elevated levels of plasma angiogenic factors are associated with human lymphatic filarial infections.

Am J Trop Med Hyg 2010 Oct;83(4):884-90

Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.4269/ajtmh.2010.10-0039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2946762PMC
October 2010

Recent advances in the diagnosis and treatment of hypereosinophilic syndromes.

Authors:
Amy D Klion

Hematology Am Soc Hematol Educ Program 2005 :209-14

Laboratory of Parasitic Diseases, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1182/asheducation-2005.1.209DOI Listing
November 2009

How I treat hypereosinophilic syndromes.

Authors:
Amy D Klion

Blood 2009 Oct 19;114(18):3736-41. Epub 2009 Aug 19.

Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1182/blood-2009-07-143552DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2773488PMC
October 2009

Hypereosinophilic syndrome: current approach to diagnosis and treatment.

Authors:
Amy Klion

Annu Rev Med 2009 ;60:293-306

Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.1146/annurev.med.60.062107.090340DOI Listing
September 2009

Molecular identification of Wolbachia from the filarial nematode Mansonella perstans.

Mol Biochem Parasitol 2008 Aug 2;160(2):123-8. Epub 2008 May 2.

Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1016/j.molbiopara.2008.04.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2497444PMC
August 2008

Rapid, novel, specific, high-throughput assay for diagnosis of Loa loa infection.

J Clin Microbiol 2008 Jul 28;46(7):2298-304. Epub 2008 May 28.

Neurobiology and Pain Therapeutics Section, Laboratory of Sensory Biology, National Institute of Dental and Craniofacial Research, National Institutes of Health, 4 Center Drive, Bethesda, Maryland 20892, USA.

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http://jcm.asm.org/content/46/7/2298.full.pdf
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http://jcm.asm.org/cgi/doi/10.1128/JCM.00490-08
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http://dx.doi.org/10.1128/JCM.00490-08DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2446928PMC
July 2008

Treatment of patients with the hypereosinophilic syndrome with mepolizumab.

N Engl J Med 2008 Mar 16;358(12):1215-28. Epub 2008 Mar 16.

Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, OH 45229, USA.

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http://dx.doi.org/10.1056/NEJMoa070812DOI Listing
March 2008

Filarial infections in travelers and immigrants.

Authors:
Amy D Klion

Curr Infect Dis Rep 2008 Mar;10(1):50-7

Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 4, Room 126, 4 Center Drive, Bethesda, MD 20892, USA.

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March 2008

Filariasis in travelers presenting to the GeoSentinel Surveillance Network.

PLoS Negl Trop Dis 2007 Dec 26;1(3):e88. Epub 2007 Dec 26.

Office of Global Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.

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http://dx.doi.org/10.1371/journal.pntd.0000088DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2154385PMC
December 2007

Year-to-year variation in the age-specific incidence of clinical malaria in two potential vaccine testing sites in Mali with different levels of malaria transmission intensity.

Am J Trop Med Hyg 2007 Dec;77(6):1028-33

Malaria Research and Training Center, Department of Epidemiology of Parasitic Diseases, Faculty of Medicine, Pharmacy and Odonto-Stomatology, University of Bamako, Bamako, Mali.

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December 2007

KIT D816V-associated systemic mastocytosis with eosinophilia and FIP1L1/PDGFRA-associated chronic eosinophilic leukemia are distinct entities.

J Allergy Clin Immunol 2007 Sep 12;120(3):680-7. Epub 2007 Jul 12.

Department of Laboratory Medicine, Clinical Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.

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http://dx.doi.org/10.1016/j.jaci.2007.05.024DOI Listing
September 2007

Approach to the therapy of hypereosinophilic syndromes.

Authors:
Amy D Klion

Immunol Allergy Clin North Am 2007 Aug;27(3):551-60

Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bldg 4, Rm. 126, 4 Center Drive, Bethesda, MD 20892, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S088985610700056
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http://dx.doi.org/10.1016/j.iac.2007.07.006DOI Listing
August 2007

Eosinophilia is associated with a higher mortality rate among patients with autoimmune lymphoproliferative syndrome.

Am J Hematol 2007 Jul;82(7):615-24

Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

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http://doi.wiley.com/10.1002/ajh.20851
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http://dx.doi.org/10.1002/ajh.20851DOI Listing
July 2007

Filaria-induced monocyte dysfunction and its reversal following treatment.

Infect Immun 2006 Aug;74(8):4409-17

Helminth Immunology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, 4 Center Drive, Room 4/126, National Institutes of Health, Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.1128/IAI.01106-05DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1539612PMC
August 2006

Approaches to the treatment of hypereosinophilic syndromes: a workshop summary report.

J Allergy Clin Immunol 2006 Jun 3;117(6):1292-302. Epub 2006 May 3.

Laboratory of Parasitic Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1016/j.jaci.2006.02.042DOI Listing
June 2006

Multilineage involvement of the fusion gene in patients with FIP1L1/PDGFRA-positive hypereosinophilic syndrome.

Br J Haematol 2006 Feb;132(3):286-92

Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-1881, USA.

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http://dx.doi.org/10.1111/j.1365-2141.2005.05863.xDOI Listing
February 2006

Selective generation of functional somatically mutated IgM+CD27+, but not Ig isotype-switched, memory B cells in X-linked lymphoproliferative disease.

J Clin Invest 2006 Feb 19;116(2):322-33. Epub 2006 Jan 19.

Lymphocyte Differentiation Laboratory, Centenary Institute of Cancer Medicine and Cell Biology, Newtown, New South Wales, Australia.

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http://dx.doi.org/10.1172/JCI25720DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1332028PMC
February 2006

Imatinib-responsive hypereosinophilia in a patient with B cell ALL.

Leuk Lymphoma 2004 Dec;45(12):2497-501

Hematology Branch, National Heart Lung and Blood Institute National Institutes of Health Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1080/10428190400005288DOI Listing
December 2004

Anti-interleukin-5 therapy for asthma and hypereosinophilic syndrome.

Immunol Allergy Clin North Am 2004 Nov;24(4):645-66, vii

Department of Allergy and Clinical Immunology, Imperial College London, National Heart and Lung Institute, Guy Scadding Building, Dovehouse Street, London, SW3 6LY UK.

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http://dx.doi.org/10.1016/j.iac.2004.06.007DOI Listing
November 2004

The etiology of severe anemia in a village and a periurban area in Mali.

Blood 2004 Aug 27;104(4):1198-200. Epub 2004 Apr 27.

Malaria Research and Training Center, Department of Epidemiology of Parasitic Diseases, Faculty of Medicine, Pharmacy and Odonto-Stomatology, University of Bamako, PO Box 1805, Bamako, Mali.

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http://dx.doi.org/10.1182/blood-2003-11-3884DOI Listing
August 2004

Genetic heterogeneity in Loa loa parasites from southern Cameroon: A preliminary study.

Filaria J 2004 Jun 29;3(1). Epub 2004 Jun 29.

Division of Geographic Medicine, University of Alabama at Birmingham, Birmingham, AL USA.

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http://dx.doi.org/10.1186/1475-2883-3-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC459234PMC
June 2004

Platelet-derived growth factor receptor inhibition to treat idiopathic hypereosinophilic syndrome.

Semin Oncol 2004 Apr;31(2 Suppl 6):12-7

Adult Leukemia Program, Dana-Farber Cancer Institute, Boston, MA 02115, USA.

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April 2004