Amy Jayne McKnight

Amy Jayne McKnight

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Amy Jayne McKnight

Amy Jayne McKnight

Publications by authors named "Amy Jayne McKnight"

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Genetic Strategies to Understand Human Diabetic Nephropathy: Wet-Lab Approaches.

Methods Mol Biol 2020 ;2067:205-240

Centre for Public Health, Queen's University Belfast, Northern Ireland, UK.

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http://dx.doi.org/10.1007/978-1-4939-9841-8_15DOI Listing
January 2020

Genetic Strategies to Understand Human Diabetic Nephropathy: In Silico Strategies for Molecular Data-Association Studies.

Methods Mol Biol 2020 ;2067:241-275

Centre for Public Health, Queen's University Belfast, Northern Ireland, UK.

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http://dx.doi.org/10.1007/978-1-4939-9841-8_16DOI Listing
January 2020

The Challenges of Chromosome Y Analysis and the Implications for Chronic Kidney Disease.

Front Genet 2019 4;10:781. Epub 2019 Sep 4.

Epidemiology and Public Health Research Group, Centre for Public Health, Queen's University of Belfast, c/o Regional Genetics Centre, Belfast City Hospital, Belfast, United Kingdom.

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http://dx.doi.org/10.3389/fgene.2019.00781DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6737325PMC
September 2019

Differential methylation as a diagnostic biomarker of rare renal diseases: a systematic review.

BMC Nephrol 2019 Aug 16;20(1):320. Epub 2019 Aug 16.

Centre for Public Health, Queen's University Belfast, c/o Regional Genetics Centre, Level A, Tower Block, Belfast City Hospital, Lisburn Road, BT9 7AB, Belfast, Northern Ireland.

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http://dx.doi.org/10.1186/s12882-019-1517-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6697952PMC
August 2019

Communication Needs for Individuals With Rare Diseases Within and Around the Healthcare System of Northern Ireland.

Front Public Health 2019 21;7:236. Epub 2019 Aug 21.

Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, United Kingdom.

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http://dx.doi.org/10.3389/fpubh.2019.00236DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6712370PMC
August 2019

Protocol for a scoping review of multi-omic analysis for rare diseases.

BMJ Open 2019 May 5;9(5):e026278. Epub 2019 May 5.

Centre for Public Health, Queen's University Belfast, Belfast, Northern Ireland, UK.

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http://dx.doi.org/10.1136/bmjopen-2018-026278DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6501961PMC
May 2019

Genetic Susceptibility to Chronic Kidney Disease - Some More Pieces for the Heritability Puzzle.

Front Genet 2019 31;10:453. Epub 2019 May 31.

Epidemiology and Public Health Research Group, Centre for Public Health, Queen's University of Belfast, Belfast, United Kingdom.

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http://dx.doi.org/10.3389/fgene.2019.00453DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6554557PMC
May 2019

Differential methylation in rare ophthalmic disorders: a systematic review protocol.

Syst Rev 2019 Apr 10;8(1):93. Epub 2019 Apr 10.

Centre for Public Health, Queen's University Belfast, c/o Regional Genetics Centre, Level A, Tower Block, Belfast City Hospital, Belfast, BT9 7AB, Co. Antrim, UK.

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https://systematicreviewsjournal.biomedcentral.com/articles/
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http://dx.doi.org/10.1186/s13643-019-0999-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456967PMC
April 2019

Communication strategies for rare cancers: a systematic review protocol.

Syst Rev 2019 Apr 23;8(1):102. Epub 2019 Apr 23.

Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, UK.

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https://systematicreviewsjournal.biomedcentral.com/articles/
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http://dx.doi.org/10.1186/s13643-019-1017-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6477728PMC
April 2019

Information on Genetic Variants Does Not Increase Identification of Individuals at Risk of Esophageal Adenocarcinoma Compared to Clinical Risk Factors.

Gastroenterology 2019 01 19;156(1):43-45. Epub 2018 Sep 19.

Cancer Epidemiology Research Group, Centre for Public Health, Queen's University Belfast, Belfast, Northern Ireland, United Kingdom; Centre for Cancer Research and Cell Biology, Queen's University Belfast, Belfast, Northern Ireland, United Kingdom.

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https://linkinghub.elsevier.com/retrieve/pii/S00165085183503
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http://dx.doi.org/10.1053/j.gastro.2018.09.038DOI Listing
January 2019

A Genome-Wide Association Study of Diabetic Kidney Disease in Subjects With Type 2 Diabetes.

Diabetes 2018 07 27;67(7):1414-1427. Epub 2018 Apr 27.

Wellcome Centre Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, U.K.

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http://dx.doi.org/10.2337/db17-0914DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6014557PMC
July 2018

Development of next generation sequencing panel for UMOD and association with kidney disease.

PLoS One 2017 13;12(6):e0178321. Epub 2017 Jun 13.

Nephrology Research, Centre for Public Health, Queen's University of Belfast, Belfast City Hospital, Belfast, Northern Ireland.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0178321PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5469457PMC
October 2017

Design and implementation of a custom next generation sequencing panel for selected vitamin D associated genes.

BMC Res Notes 2017 Jul 28;10(1):348. Epub 2017 Jul 28.

Nephrology Research Group, Centre for Public Health, Queen's University Belfast, Belfast, BT9 7AB, UK.

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http://dx.doi.org/10.1186/s13104-017-2664-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5534126PMC
July 2017

Genetics of diabetic nephropathy: a long road of discovery.

Curr Diab Rep 2015 Jul;15(7):41

Nephrology Research Group, Centre for Public Health, Queen's University Belfast, c/o Regional Genetics Centre, Level A, Tower Block, Belfast City Hospital, Lisburn Road, Belfast, BT9 7AB, UK,

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http://dx.doi.org/10.1007/s11892-015-0610-9DOI Listing
July 2015

Epigenome-wide association study for Parkinson's disease.

Neuromolecular Med 2014 Dec 11;16(4):845-55. Epub 2014 Oct 11.

Queens University Belfast, Belfast, UK,

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http://dx.doi.org/10.1007/s12017-014-8332-8DOI Listing
December 2014

Genetic polymorphisms and kidney transplant outcomes.

Curr Opin Nephrol Hypertens 2014 Nov;23(6):605-10

aDepartment of Nephrology and Kidney Transplantation, Queen Elizabeth Hospital Birmingham bCentre for Translational Inflammation Research, University of Birmingham, Birmingham, UK cRegional Nephrology Unit, Belfast City Hospital, Belfast, Northern Ireland.

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http://pdfs.journals.lww.com/co-nephrolhypertens/2014/11000/
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http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:land
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http://dx.doi.org/10.1097/MNH.0000000000000068DOI Listing
November 2014

β cell glucotoxic-associated single nucleotide polymorphisms in impaired glucose tolerance and new-onset diabetes after transplantation.

Transplantation 2014 Aug;98(3):e19-20

1 Department of Nephrology and Kidney Transplantation Queen Elizabeth Hospital Birmingham, United Kingdom 2 Centre for Translational Inflammation Research, University of Birmingham Birmingham, United Kingdom 3 Regional Nephrology Unit Belfast City Hospital Belfast, Northern Ireland.

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http://dx.doi.org/10.1097/TP.0000000000000268DOI Listing
August 2014

Genetics of new-onset diabetes after transplantation.

J Am Soc Nephrol 2014 May 5;25(5):1037-49. Epub 2013 Dec 5.

Nephrology Research Group, Queen's University, Belfast, Northern Ireland; and Regional Nephrology Unit, Belfast City Hospital, Belfast, Northern Ireland.

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http://dx.doi.org/10.1681/ASN.2013040383DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4005297PMC
May 2014

The changing landscape of diabetic kidney disease: new reflections on phenotype, classification, and disease progression to influence future investigative studies and therapeutic trials.

Adv Chronic Kidney Dis 2014 May;21(3):256-9

Centre for Public Health, Queen's University of Belfast, Belfast, Northern Ireland, United Kingdom.

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http://dx.doi.org/10.1053/j.ackd.2014.03.002DOI Listing
May 2014

Genetic and epigenetic risk factors for diabetic kidney disease.

Adv Chronic Kidney Dis 2014 May;21(3):287-96

Nephrology Research, Centre for Public Health, Queen's University of Belfast, Belfast, Northern Ireland, United Kingdom.

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http://dx.doi.org/10.1053/j.ackd.2014.03.010DOI Listing
May 2014

DNA hypermethylation and DNA hypomethylation is present at different loci in chronic kidney disease.

Epigenetics 2014 Mar 19;9(3):366-76. Epub 2013 Nov 19.

Nephrology Research; Centre for Public Health; Queen's University of Belfast; Belfast Northern Ireland.

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http://dx.doi.org/10.4161/epi.27161DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4053455PMC
March 2014

An excess of risk-increasing low-frequency variants can be a signal of polygenic inheritance in complex diseases.

Am J Hum Genet 2014 Mar;94(3):437-52

Department of Genetics, Harvard Medical School, Boston, MA 02115, USA; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA 02142, USA; Department of Endocrinology, Boston Children's Hospital, Boston, MA 02115, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00029297140006
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http://dx.doi.org/10.1016/j.ajhg.2014.02.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3951950PMC
March 2014

Association analysis of dyslipidemia-related genes in diabetic nephropathy.

PLoS One 2013 26;8(3):e58472. Epub 2013 Mar 26.

Nephrology Research Group, Centre for Public Health, Queen's University Belfast, Belfast, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0058472PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3608831PMC
September 2013

Haplotype association analysis of genes within the WNT signalling pathways in diabetic nephropathy.

BMC Nephrol 2013 Jun 18;14:126. Epub 2013 Jun 18.

Nephrology Research Group, Centre for Public Health, Queen's University Belfast, Belfast BT12 6BJ, UK.

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http://dx.doi.org/10.1186/1471-2369-14-126DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3701522PMC
June 2013

Association of MYH9/APOL1 with chronic kidney disease in a UK population.

Nephrol Dial Transplant 2012 Sep 17;27(9):3660; author reply 660-1. Epub 2012 Jul 17.

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http://dx.doi.org/10.1093/ndt/gfs181DOI Listing
September 2012

New susceptibility loci associated with kidney disease in type 1 diabetes.

PLoS Genet 2012 Sep 20;8(9):e1002921. Epub 2012 Sep 20.

Folkhälsan Institute of Genetics, Folkhälsan Research Center, Biomedicum Helsinki, Helsinki, Finland.

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http://pure.qub.ac.uk/portal/files/2407268/New_Susceptibilit
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http://dx.plos.org/10.1371/journal.pgen.1002921
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http://dx.doi.org/10.1371/journal.pgen.1002921DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3447939PMC
September 2012

Epigenetics: time to translate into transplantation.

Transplantation 2012 Jul;94(1):1-7

Regional Nephrology Unit (Level 11), Belfast City Hospital, Lisburn Road, Belfast, Northern Ireland.

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http://dx.doi.org/10.1097/TP.0b013e31824db9bdDOI Listing
July 2012

Association analysis of canonical Wnt signalling genes in diabetic nephropathy.

PLoS One 2011 18;6(8):e23904. Epub 2011 Aug 18.

Nephrology Research Group, Centre for Public Health, Queen's University Belfast, Belfast, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0023904PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3158097PMC
December 2011

A GREM1 gene variant associates with diabetic nephropathy.

J Am Soc Nephrol 2010 May 11;21(5):773-81. Epub 2010 Feb 11.

Nephrology Research Group, Queen's University of Belfast, c/o Regional Genetics Centre, Belfast City Hospital, Northern Ireland, United Kingdom.

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http://dx.doi.org/10.1681/ASN.2009070773DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2865734PMC
May 2010

Resequencing of the CCL5 and CCR5 genes and investigation of variants for association with diabetic nephropathy.

J Hum Genet 2010 Apr 5;55(4):248-51. Epub 2010 Mar 5.

Nephrology Research Group, Queens University Belfast, Belfast, Northern Ireland, UK.

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http://dx.doi.org/10.1038/jhg.2010.15DOI Listing
April 2010

Association of caveolin-1 gene polymorphism with kidney transplant fibrosis and allograft failure.

JAMA 2010 Apr;303(13):1282-7

Department of Nephrology and Transplantation, Renal Institute of Birmingham, University Hospital Birmingham, Birmingham B15 2TH, England.

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http://dx.doi.org/10.1001/jama.2010.356DOI Listing
April 2010

Variation in RTN3 and PPIL2 genes does not influence platelet membrane beta-secretase activity or susceptibility to alzheimer's disease in the northern Irish population.

Neuromolecular Med 2009 ;11(4):337-44

Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Whitla Medical Building, 97 Lisburn Road, Belfast, BT9 7BL, Northern Ireland, UK.

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http://dx.doi.org/10.1007/s12017-009-8080-3DOI Listing
March 2010

Genetic analysis of coronary artery disease single-nucleotide polymorphisms in diabetic nephropathy.

Nephrol Dial Transplant 2009 Aug 31;24(8):2473-6. Epub 2009 Mar 31.

Nephrology Research Group, Queen's University of Belfast, Belfast, Northern Ireland.

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http://dx.doi.org/10.1093/ndt/gfp015DOI Listing
August 2009

Annotated chromosome maps for renal disease.

Hum Mutat 2009 Mar;30(3):314-20

Nephrology Research Group, Queen's University of Belfast, United Kingdom.

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http://dx.doi.org/10.1002/humu.20885DOI Listing
March 2009

Association of VEGF-1499C-->T polymorphism with diabetic nephropathy in type 1 diabetes mellitus.

J Diabetes Complications 2007 Jul-Aug;21(4):242-5

Nephrology Research Group, Queen's University of Belfast, Belfast, UK.

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http://dx.doi.org/10.1016/j.jdiacomp.2006.05.005DOI Listing
September 2007

Gene discovery in diabetic nephropathy.

Curr Diab Rep 2007 Apr;7(2):139-45

Nephrology Research Laboratory, Queen's University Belfast, Regional Genetics Centre, Belfast City Hospital, Lisburn Road, Belfast BT9 7AB, Northern Ireland.

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http://dx.doi.org/10.1007/s11892-007-0023-5DOI Listing
April 2007

Resequencing of the characterised CTGF gene to identify novel or known variants, and analysis of their association with diabetic nephropathy.

J Hum Genet 2006 24;51(4):383-6. Epub 2006 Feb 24.

Nephrology Research Group, Queen's University of Belfast, c/o Regional Genetics Centre, Level A, Tower Block, Belfast City Hospital, Lisburn Road, BT9 7AB, Belfast, Northern Ireland.

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http://dx.doi.org/10.1007/s10038-006-0368-7DOI Listing
May 2006

A genome-wide DNA microsatellite association screen to identify chromosomal regions harboring candidate genes in diabetic nephropathy.

J Am Soc Nephrol 2006 Mar 8;17(3):831-6. Epub 2006 Feb 8.

Nephrology Research Group, Department of Epidemiology & Public Health, Queen's University Belfast, Northern Ireland.

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http://dx.doi.org/10.1681/ASN.2005050493DOI Listing
March 2006

Role of alpha-adducin DNA polymorphisms in the genetic predisposition to diabetic nephropathy.

Nephrol Dial Transplant 2004 Aug 8;19(8):2019-24. Epub 2004 Jun 8.

Nephrology Research Group, Queen's University of Belfast, Northern Ireland.

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http://dx.doi.org/10.1093/ndt/gfh342DOI Listing
August 2004