Amy Harms

Amy Harms

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Amy Harms

Amy Harms

Publications by authors named "Amy Harms"

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Mechanistic and Quantitative Understanding of Pharmacokinetics in Zebrafish Larvae through Nanoscale Blood Sampling and Metabolite Modeling of Paracetamol.

J Pharmacol Exp Ther 2019 Oct 1;371(1):15-24. Epub 2019 Aug 1.

Systems Biomedicine and Pharmacology, Leiden Academic Centre for Drug Research (R.C.v.W., E.H.J.K., V.K., T.K., A.C.H., T.H., P.H.v.d.G.) and Animal Sciences and Health, Institute of Biology Leiden (A.O., H.P.S.), Leiden University, Leiden, The Netherlands; and Certara QSP, Canterbury, United Kingdom (P.H.v.d.G.)

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http://dx.doi.org/10.1124/jpet.119.260299DOI Listing
October 2019

Fast LC-ESI-MS/MS analysis and influence of sampling conditions for gut metabolites in plasma and serum.

Sci Rep 2019 Aug 26;9(1):12370. Epub 2019 Aug 26.

Analytical Biosciences and Metabolomics, Division of Systems Biomedicine and Pharmacology, Leiden Academic Center for Drug Research, Leiden University, Leiden, 2333 CC, The Netherlands.

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http://dx.doi.org/10.1038/s41598-019-48876-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6710273PMC
August 2019

LC-MS/MS analysis of the central energy and carbon metabolites in biological samples following derivatization by dimethylaminophenacyl bromide.

J Chromatogr A 2019 Jul 31:460413. Epub 2019 Jul 31.

Analytical Biosciences and Metabolomics, Division of Systems Biomedicine and Pharmacology, Leiden Academic Centre for Drug Research, Leiden University, Leiden, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.chroma.2019.460413DOI Listing
July 2019

Impact of post-hatching maturation on the pharmacokinetics of paracetamol in zebrafish larvae.

Sci Rep 2019 Feb 15;9(1):2149. Epub 2019 Feb 15.

Animal Sciences and Health, Institute of Biology Leiden (IBL), Leiden University, Leiden, The Netherlands.

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http://www.nature.com/articles/s41598-019-38530-w
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http://dx.doi.org/10.1038/s41598-019-38530-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6377609PMC
February 2019

Role of amino acids in rheumatoid arthritis studied by metabolomics.

Int J Rheum Dis 2019 Jan 22;22(1):38-46. Epub 2017 Mar 22.

Analytical BioSciences, LACDR, Leiden University, Leiden, the Netherlands.

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http://dx.doi.org/10.1111/1756-185X.13062DOI Listing
January 2019

High-Resolution Analysis of the Peptidoglycan Composition in Streptomyces coelicolor.

J Bacteriol 2018 10 24;200(20). Epub 2018 Sep 24.

Molecular Biotechnology, Institute of Biology, Leiden University, Leiden, The Netherlands

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http://jb.asm.org/lookup/doi/10.1128/JB.00290-18
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http://dx.doi.org/10.1128/JB.00290-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6153666PMC
October 2018

The influence of neuronal electrical activity on the mammalian central clock metabolome.

Metabolomics 2018 09 17;14(10):122. Epub 2018 Sep 17.

Department of Cellular and Chemical Biology, Leiden University Medical Center, Einthovenweg 20, 2333 ZC, Leiden, The Netherlands.

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http://dx.doi.org/10.1007/s11306-018-1423-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6153692PMC
September 2018

Gene Expression of Endocannabinoid System Components in Skeletal Muscle and Adipose Tissue of South Asians and White Caucasians with Overweight.

Obesity (Silver Spring) 2018 08 1;26(8):1332-1337. Epub 2018 Aug 1.

Department of Medicine, Division of Endocrinology Leiden University Medical Center, Leiden, the Netherlands.

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http://dx.doi.org/10.1002/oby.22245DOI Listing
August 2018

Development and application of a UHPLC-MS/MS metabolomics based comprehensive systemic and tissue-specific screening method for inflammatory, oxidative and nitrosative stress.

Anal Bioanal Chem 2018 Apr 2;410(10):2551-2568. Epub 2018 Mar 2.

Department of Analytical Biosciences, Leiden Academic Centre for Drug Research, Leiden University, Einsteinweg 55, 2333 CC, Leiden, Netherlands.

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http://dx.doi.org/10.1007/s00216-018-0912-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5857282PMC
April 2018

A metabolomics study of Qiliqiangxin in a rat model of heart failure: a reverse pharmacology approach.

Sci Rep 2018 02 27;8(1):3688. Epub 2018 Feb 27.

LU-European Center for Chinese Medicine and Natural Compounds, Institute of Biology, Leiden University, Sylviusweg72, 2333BE, Leiden, The Netherlands.

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http://dx.doi.org/10.1038/s41598-018-22074-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5829193PMC
February 2018

A Mendelian Randomization Study of Metabolite Profiles, Fasting Glucose, and Type 2 Diabetes.

Diabetes 2017 11 28;66(11):2915-2926. Epub 2017 Aug 28.

Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands

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http://dx.doi.org/10.2337/db17-0199DOI Listing
November 2017

Improvement of Insulin Sensitivity after Lean Donor Feces in Metabolic Syndrome Is Driven by Baseline Intestinal Microbiota Composition.

Cell Metab 2017 Oct;26(4):611-619.e6

Department of Vascular Medicine, Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, the Netherlands; Top Institute of Food and Nutrition, 6700 AN Wageningen, the Netherlands; Department of Internal Medicine, VUMC, Free University, Amsterdam, the Netherlands; Wallenberg Laboratory, Sahlgrenska Hospital, University of Gothenburg, Gothenburg, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2017.09.008DOI Listing
October 2017

Amine Metabolism Is Influenced by Dietary Protein Source.

Front Nutr 2017 1;4:41. Epub 2017 Sep 1.

Host-Microbe Interactomics Group, Wageningen University & Research, Wageningen, Netherlands.

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http://dx.doi.org/10.3389/fnut.2017.00041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5585152PMC
September 2017

Blood-based metabolic signatures in Alzheimer's disease.

Alzheimers Dement (Amst) 2017 6;8:196-207. Epub 2017 Sep 6.

Neurochemistry Laboratory and Biobank, Department of Clinical Chemistry, Amsterdam Neuroscience, VU University Medical Center Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.dadm.2017.07.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5607205PMC
September 2017

Endocannabinoid tone is higher in healthy lean South Asian than white Caucasian men.

Sci Rep 2017 08 8;7(1):7558. Epub 2017 Aug 8.

Department of Medicine, Division of Endocrinology, Leiden University Medical Center, Albinusdreef 2, Leiden, 2333 ZA, The Netherlands.

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http://dx.doi.org/10.1038/s41598-017-07980-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5548787PMC
August 2017

Serum-Based Oxylipins Are Associated with Outcomes in Primary Prevention Implantable Cardioverter Defibrillator Patients.

PLoS One 2016 9;11(6):e0157035. Epub 2016 Jun 9.

Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0157035PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4900660PMC
July 2017

Pharmacokinetic Modeling of Paracetamol Uptake and Clearance in Zebrafish Larvae: Expanding the Allometric Scale in Vertebrates with Five Orders of Magnitude.

Zebrafish 2016 12 15;13(6):504-510. Epub 2016 Sep 15.

1 Division of Analytical Biosciences, Systems Pharmacology Cluster, Leiden Academic Centre for Drug Research, Leiden University , Leiden, The Netherlands .

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http://dx.doi.org/10.1089/zeb.2016.1313DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5124745PMC
December 2016

Integration of pharmacometabolomics with pharmacokinetics and pharmacodynamics: towards personalized drug therapy.

Metabolomics 2017 19;13(1). Epub 2016 Dec 19.

Division of Analytical Biosciences, Systems Pharmacology Cluster, Leiden Academic Centre for Drug Research, Leiden University, Einsteinweg 55, 2333 CC Leiden, The Netherlands.

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http://dx.doi.org/10.1007/s11306-016-1143-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5165030PMC
December 2016

Serum amine-based metabolites and their association with outcomes in primary prevention implantable cardioverter-defibrillator patients.

Europace 2016 Sep 25;18(9):1383-90. Epub 2015 Oct 25.

Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, 600 N. Wolfe Street, Halsted 565, Baltimore, MD 21287, USA

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http://dx.doi.org/10.1093/europace/euv342DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5006959PMC
September 2016

Collagen Induced Arthritis in DBA/1J Mice Associates with Oxylipin Changes in Plasma.

Mediators Inflamm 2015 29;2015:543541. Epub 2015 Oct 29.

Analytical BioSciences, LACDR, Leiden University, P.O. Box 9502, 2300 RA Leiden, Netherlands ; Sino-Dutch Centre for Preventive and Personalized Medicine, Leiden University, P.O. Box 9502, 2300 RA Leiden, Netherlands ; TNO Innovation for Life, P.O. Box 360, 3700 AJ Zeist, Netherlands.

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http://dx.doi.org/10.1155/2015/543541DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4641941PMC
September 2016

Metabolomics profiling of the free and total oxidised lipids in urine by LC-MS/MS: application in patients with rheumatoid arthritis.

Anal Bioanal Chem 2016 Sep 12;408(23):6307-19. Epub 2016 Jul 12.

Department of Analytical Biosciences, Leiden Academic Center for Drug Research, Leiden University, Einsteinweg 55, 2333 CC, Leiden, The Netherlands.

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http://dx.doi.org/10.1007/s00216-016-9742-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5009176PMC
September 2016

Metabolic characterization of the natural progression of chronic hepatitis B.

Genome Med 2016 06 10;8(1):64. Epub 2016 Jun 10.

Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center Rotterdam, Wytemaweg 80, Room Na-1011, 3015, CE, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1186/s13073-016-0318-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4902991PMC
June 2016

First-Trimester Serum Acylcarnitine Levels to Predict Preeclampsia: A Metabolomics Approach.

Dis Markers 2015 4;2015:857108. Epub 2015 Jun 4.

Centre for Health Protection (GZB), National Institute for Public Health and the Environment (RIVM), 3720 BA Bilthoven, Netherlands.

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http://dx.doi.org/10.1155/2015/857108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4471382PMC
February 2016

Quantitative profiling of oxylipins in plasma and atherosclerotic plaques of hypercholesterolemic rabbits.

Anal Bioanal Chem 2016 Jan 28;408(1):97-105. Epub 2015 Oct 28.

Merck and Co., Inc, Merck Research Laboratories, Kenilworth, NJ, 07033, USA.

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http://dx.doi.org/10.1007/s00216-015-9105-4DOI Listing
January 2016

Oxylipid Profile of Low-Dose Aspirin Exposure: A Pharmacometabolomics Study.

J Am Heart Assoc 2015 Oct 26;4(10):e002203. Epub 2015 Oct 26.

Duke University Medical Center, Durham, NC (A.G., R.K.D.) Department of Psychiatry and Behavioral Sciences, Duke University, Durham, NC (R.K.D.) Duke Institute for Brain Sciences, Duke University, Durham, NC (R.K.D.) Institute of Genome Science and Policy, Durham, NC (R.K.D.).

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http://dx.doi.org/10.1161/JAHA.115.002203DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4845113PMC
October 2015

Metabolomics profiling for identification of novel potential markers in early prediction of preeclampsia.

PLoS One 2014 29;9(5):e98540. Epub 2014 May 29.

Leiden Academic Center for Drug Research, Division of Analytical Biosciences, Leiden University, Leiden, The Netherlands; The Netherlands Metabolomics Centre, Leiden University, Leiden, the Netherlands.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0098540PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4038585PMC
January 2015

Roux-en-Y gastric bypass surgery, but not calorie restriction, reduces plasma branched-chain amino acids in obese women independent of weight loss or the presence of type 2 diabetes.

Diabetes Care 2014 Dec 14;37(12):3150-6. Epub 2014 Oct 14.

Department of Endocrinology and Metabolism, Leiden University Medical Center, Leiden, the Netherlands Department of Human Genetics, Leiden University Medical Center, Leiden, the Netherlands Einthoven Laboratory for Experimental Vascular Medicine, Leiden, the Netherlands.

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http://dx.doi.org/10.2337/dc14-0195DOI Listing
December 2014

Metabolomic profiling reveals suppression of oxylipin biosynthesis during the early stages of legume-rhizobia symbiosis.

FEBS Lett 2012 Sep 13;586(19):3150-8. Epub 2012 Jul 13.

Department of Biochemistry, University of Wisconsin, Madison, Wisconsin 53706, USA.

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http://dx.doi.org/10.1016/j.febslet.2012.06.046DOI Listing
September 2012

Proteomic analysis of Schistosoma mansoni proteins released during in vitro miracidium-to-sporocyst transformation.

Mol Biochem Parasitol 2009 Mar 27;164(1):32-44. Epub 2008 Nov 27.

Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin, Madison, WI 53706, United States.

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http://dx.doi.org/10.1016/j.molbiopara.2008.11.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2665799PMC
March 2009

Stable isotope assisted assignment of elemental compositions for metabolomics.

Anal Chem 2007 Sep 21;79(18):6912-21. Epub 2007 Aug 21.

Department of Biochemistry, University of Wisconsin, 433 Babcock Drive, Madison, Wisconsin 53706, USA.

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http://dx.doi.org/10.1021/ac070346tDOI Listing
September 2007

Comparison of full versus partial metabolic labeling for quantitative proteomics analysis in Arabidopsis thaliana.

Mol Cell Proteomics 2007 May 9;6(5):860-81. Epub 2007 Feb 9.

Department of Biochemistry, University of Wisconsin, Madison, Wisconsin 53706, USA.

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http://www.mcponline.org/content/6/5/860.full.pdf
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http://www.mcponline.org/cgi/doi/10.1074/mcp.M600347-MCP200
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http://dx.doi.org/10.1074/mcp.M600347-MCP200DOI Listing
May 2007

Implications of 15N-metabolic labeling for automated peptide identification in Arabidopsis thaliana.

Proteomics 2007 Apr;7(8):1279-92

Department of Comparative Biosciences, University of Wisconsin, Madison, WI, USA.

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http://doi.wiley.com/10.1002/pmic.200600832
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http://dx.doi.org/10.1002/pmic.200600832DOI Listing
April 2007

A quantitative analysis of Arabidopsis plasma membrane using trypsin-catalyzed (18)O labeling.

Mol Cell Proteomics 2006 Aug 24;5(8):1382-95. Epub 2006 Apr 24.

Biotechnology Center, University of Wisconsin, Madison, Wisconsin 53706, USA.

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http://dx.doi.org/10.1074/mcp.M500414-MCP200DOI Listing
August 2006

An isotope labeling strategy for quantifying the degree of phosphorylation at multiple sites in proteins.

J Am Soc Mass Spectrom 2004 May;15(5):647-53

Biotechnology Center, University of Wisconsin-Madison, Madison, Wisconsin 53706, USA.

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http://dx.doi.org/10.1016/j.jasms.2003.12.019DOI Listing
May 2004

Identification of a novel pyridoxal 5'-phosphate binding site in adenosylcobalamin-dependent lysine 5,6-aminomutase from Porphyromonas gingivalis.

Biochemistry 2002 Jul;41(27):8767-76

Department of Biochemistry, University of Wisconsin-Madison, 1710 University Avenue, Madison, Wisconsin 53726, USA.

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http://dx.doi.org/10.1021/bi020255kDOI Listing
July 2002