Amy H Newman

Amy H Newman

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Amy H Newman

Amy H Newman

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Pharmacological classification of centrally acting drugs using EEG in freely moving rats: an old tool to identify new atypical dopamine uptake inhibitors.

Neuropharmacology 2019 12 24;161:107446. Epub 2018 Nov 24.

Medication Development Program, Molecular Targets and Medications Discovery Branch, NIDA-IRP, NIH/DHHS, Baltimore, MD, USA.

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http://dx.doi.org/10.1016/j.neuropharm.2018.11.034DOI Listing
December 2019

Biased G Protein-Independent Signaling of Dopamine D-D Receptor Heteromers in the Nucleus Accumbens.

Mol Neurobiol 2019 Oct 27;56(10):6756-6769. Epub 2019 Mar 27.

Integrative Neurobiology Section, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Baltimore, MD, 21224, USA.

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http://dx.doi.org/10.1007/s12035-019-1564-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6728209PMC
October 2019

Synaptic Vesicle Recycling Pathway Determines Neurotransmitter Content and Release Properties.

Neuron 2019 05 16;102(4):786-800.e5. Epub 2019 Apr 16.

Departments of Neurology and Physiology, Graduate Programs in Neuroscience and Cell Biology, Kavli Institute for Fundamental Neuroscience, Weill Institute for the Neurosciences, UCSF School of Medicine, San Francisco, CA 94143, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2019.03.031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6541489PMC
May 2019

Pharmacological profiling of sigma 1 receptor ligands by novel receptor homomer assays.

Neuropharmacology 2018 05 31;133:264-275. Epub 2018 Jan 31.

Computational Chemistry and Molecular Biophysics Unit, Molecular Targets and Medications Discovery Branch, National Institute on Drug Abuse, Intramural Research Program, National Institute of Health, 333 Cassell Drive, Baltimore, MD 21224, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuropharm.2018.01.042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5858991PMC
May 2018

Regional Heterogeneity of D2-Receptor Signaling in the Dorsal Striatum and Nucleus Accumbens.

Neuron 2018 05 12;98(3):575-587.e4. Epub 2018 Apr 12.

Department of Pharmacology, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, CO 80045, USA; Department of Physiology and Biophysics, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2018.03.038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6048973PMC
May 2018

Targeting hypersensitive corticostriatal terminals in restless legs syndrome.

Ann Neurol 2017 Dec 7;82(6):951-960. Epub 2017 Dec 7.

Integrative Neurobiology Section, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Baltimore, MD.

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http://dx.doi.org/10.1002/ana.25104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5739944PMC
December 2017

A Novel PKC Inhibitor Shows Promise for Amphetamine Use Disorders.

Authors:
Amy H Newman

Neuropsychopharmacology 2017 09 8;42(10):1929-1930. Epub 2017 Jun 8.

Medicinal Chemistry Section, Molecular Targets and Medications Discovery Branch, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Baltimore, MD, USA.

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http://dx.doi.org/10.1038/npp.2017.116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5561339PMC
September 2017

Targeting of dopamine transporter to filopodia requires an outward-facing conformation of the transporter.

Sci Rep 2017 07 14;7(1):5399. Epub 2017 Jul 14.

Department of Cell Biology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.

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http://dx.doi.org/10.1038/s41598-017-05637-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5511133PMC
July 2017

The unique psychostimulant profile of (±)-modafinil: investigation of behavioral and neurochemical effects in mice.

Eur J Neurosci 2017 01 11;45(1):167-174. Epub 2016 Sep 11.

Medication Development Program, Molecular Targets and Medications Discovery Branch, Department of Health and Human Services, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, 333 Cassell Drive, Baltimore, MD, 21224, USA.

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http://dx.doi.org/10.1111/ejn.13376DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5604337PMC
January 2017

Differential Internalization Rates and Postendocytic Sorting of the Norepinephrine and Dopamine Transporters Are Controlled by Structural Elements in the N Termini.

J Biol Chem 2016 Mar 19;291(11):5634-51. Epub 2016 Jan 19.

From the Molecular Neuropharmacology and Genetics Laboratory, Department of Neuroscience and Pharmacology, Faculty of Health and Medical Sciences, Panum Institute 18.6, University of Copenhagen, DK-2200 Copenhagen, Denmark,

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http://dx.doi.org/10.1074/jbc.M115.702050DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4786704PMC
March 2016

Effects of buspirone and the dopamine D3 receptor compound PG619 on cocaine and methamphetamine self-administration in rhesus monkeys using a food-drug choice paradigm.

Psychopharmacology (Berl) 2015 Apr 21;232(7):1279-89. Epub 2014 Oct 21.

Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC, 27157-1083, USA.

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http://link.springer.com/content/pdf/10.1007/s00213-014-3760
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http://link.springer.com/10.1007/s00213-014-3760-6
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http://dx.doi.org/10.1007/s00213-014-3760-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4754084PMC
April 2015

Preference for distinct functional conformations of the dopamine transporter alters the relationship between subjective effects of cocaine and stimulation of mesolimbic dopamine.

Biol Psychiatry 2014 Nov 19;76(10):802-9. Epub 2014 Apr 19.

Psychobiology, Molecular Targets and Medications Discovery Branch, National Institute on Drug Abuse/Intramural Research Program/National Institutes of Health/Department of Health and Human Services, Baltimore, Maryland; Medications Development Program, Molecular Targets and Medications Discovery Branch, National Institute on Drug Abuse/Intramural Research Program/National Institutes of Health/Department of Health and Human Services, Baltimore, Maryland. Electronic address:

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http://dx.doi.org/10.1016/j.biopsych.2014.03.031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4353924PMC
November 2014

Further characterization of quinpirole-elicited yawning as a model of dopamine D3 receptor activation in male and female monkeys.

J Pharmacol Exp Ther 2014 Aug 29;350(2):205-11. Epub 2014 May 29.

Departments of Physiology and Pharmacology (S.E.M., S.H.N., P.W.C., W.S.J., A.N.D., M.A.N.) and Radiology (P.K.G., S.G., M.A.N.), Wake Forest School of Medicine, Winston-Salem, North Carolina; and the Intramural Research Program (A.H.N.), National Institute on Drug Abuse, Baltimore, Maryland

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http://dx.doi.org/10.1124/jpet.114.214833DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4109495PMC
August 2014

Dopamine D(3) receptors contribute to methamphetamine-induced alterations in dopaminergic neuronal function: role of hyperthermia.

Eur J Pharmacol 2014 Jun 28;732:105-10. Epub 2014 Mar 28.

Department of Pharmacology and Toxicology, University of Utah, Salt Lake City, Utah, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ejphar.2014.03.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4060957PMC
June 2014

2-isoxazol-3-phenyltropane derivatives of cocaine: molecular and atypical system effects at the dopamine transporter.

J Pharmacol Exp Ther 2014 May 11;349(2):297-309. Epub 2014 Feb 11.

Psychobiology (T.H., D.S.W., T.A.K., J.L.K.), Cellular Pathobiology Section (W.C.H.), Medicinal Chemistry (M.F.Z., A.H.N.), and Electrophysiology (C.R.L.) Sections, Intramural Research Program, Department of Health and Human Services, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland; and Texas Tech University, College of Education, Lubbock, Texas (P.L.S.).

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http://dx.doi.org/10.1124/jpet.113.212738DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3989806PMC
May 2014

Feeding condition and the relative contribution of different dopamine receptor subtypes to the discriminative stimulus effects of cocaine in rats.

Psychopharmacology (Berl) 2014 Feb 13;231(3):581-91. Epub 2013 Sep 13.

Department of Pharmacology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, Mail Code 7764, San Antonio, TX, 78229, USA.

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http://dx.doi.org/10.1007/s00213-013-3271-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3947133PMC
February 2014

A C-terminal PDZ domain-binding sequence is required for striatal distribution of the dopamine transporter.

Nat Commun 2013 ;4:1580

Molecular Neuropharmacology Laboratory, Lundbeck Foundation Center for Biomembranes in Nanomedicine, Department of Neuroscience and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

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http://dx.doi.org/10.1038/ncomms2568DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3646413PMC
June 2013

The stereotypy-inducing effects of N-substituted benztropine analogs alone and in combination with cocaine do not account for their blockade of cocaine self-administration.

Psychopharmacology (Berl) 2013 Feb 14;225(3):733-42. Epub 2012 Sep 14.

Psychobiology Section, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, 251 Bayview Blvd, Baltimore, MD 21224, USA.

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http://dx.doi.org/10.1007/s00213-012-2862-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4472487PMC
February 2013

Effects of pramipexole on the reinforcing effectiveness of stimuli that were previously paired with cocaine reinforcement in rats.

Psychopharmacology (Berl) 2012 Jan 24;219(1):123-35. Epub 2011 Jun 24.

Department of Pharmacology, University of Michigan Medical School, 1301 MSRB III, 1150 W. Medical Center Drive, Ann Arbor, MI 48109-0632, USA.

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http://link.springer.com/content/pdf/10.1007/s00213-011-2382
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http://link.springer.com/10.1007/s00213-011-2382-5
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http://dx.doi.org/10.1007/s00213-011-2382-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3800033PMC
January 2012

Drinking sucrose enhances quinpirole-induced yawning in rats.

Behav Pharmacol 2011 Dec;22(8):773-8

Department of Pharmacology, University of Texas Health Science Center, San Antonio, Texas, USA.

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http://dx.doi.org/10.1097/FBP.0b013e32834d0f3cDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3212635PMC
December 2011

Decreases in cocaine self-administration with dual inhibition of the dopamine transporter and σ receptors.

J Pharmacol Exp Ther 2011 Nov 22;339(2):662-77. Epub 2011 Aug 22.

Psychobiology Section, Medications Discovery Research Branch, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, 251 Bayview Blvd., Suite 200, Baltimore, MD 21224, USA.

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http://dx.doi.org/10.1124/jpet.111.185025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3199989PMC
November 2011

Influence of body weight and type of chow on the sensitivity of rats to the behavioral effects of the direct-acting dopamine-receptor agonist quinpirole.

Psychopharmacology (Berl) 2011 Oct 5;217(4):573-85. Epub 2011 May 5.

Department of Pharmacology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229-3900, USA.

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http://link.springer.com/10.1007/s00213-011-2320-6
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http://dx.doi.org/10.1007/s00213-011-2320-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3875398PMC
October 2011

Effects of selective dopaminergic compounds on a delay-discounting task.

Behav Pharmacol 2011 Aug;22(4):300-11

Behavioral Pharmacology Research Unit, Johns Hopkins University School of Medicine, Baltimore, Maryland 21224, USA.

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http://dx.doi.org/10.1097/FBP.0b013e3283473bcbDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3135665PMC
August 2011

Dopamine transporter-dependent and -independent striatal binding of the benztropine analog JHW 007, a cocaine antagonist with low abuse liability.

J Pharmacol Exp Ther 2010 Dec 20;335(3):703-14. Epub 2010 Sep 20.

Psychobiology Section, Medications Discovery Research Branch, National Institute on Drug Abuse Intramural Research Program, Baltimore, Maryland 21224, USA.

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http://jpet.aspetjournals.org/cgi/doi/10.1124/jpet.110.17162
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http://dx.doi.org/10.1124/jpet.110.171629DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3202473PMC
December 2010

Imaging brain regional and cortical laminar effects of selective D3 agonists and antagonists.

Psychopharmacology (Berl) 2010 Sep 14;212(1):59-72. Epub 2010 Jul 14.

Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Charlestown, 02129, USA.

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http://dx.doi.org/10.1007/s00213-010-1924-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3822611PMC
September 2010

The dopamine D3 receptor partial agonist CJB090 and antagonist PG01037 decrease progressive ratio responding for methamphetamine in rats with extended-access.

Addict Biol 2010 Jul 29;15(3):312-23. Epub 2010 Apr 29.

The Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1111/j.1369-1600.2010.00211.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2903631PMC
July 2010

Discovery of drugs to treat cocaine dependence: behavioral and neurochemical effects of atypical dopamine transport inhibitors.

Adv Pharmacol 2009 27;57:253-89. Epub 2009 Nov 27.

Medications Discovery Research Branch, Intramural Research Program, Department of Health and Human Services, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland 21224, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S10543589085700
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http://dx.doi.org/10.1016/S1054-3589(08)57007-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6768413PMC
June 2010

Yawning and locomotor behavior induced by dopamine receptor agonists in mice and rats.

Behav Pharmacol 2010 May;21(3):171-81

Psychobiology Section, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Baltimore, Maryland 21224, USA.

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http://dx.doi.org/10.1097/FBP.0b013e32833a5c68DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3103047PMC
May 2010

The N terminus of monoamine transporters is a lever required for the action of amphetamines.

J Biol Chem 2010 Apr 29;285(14):10924-38. Epub 2010 Jan 29.

Center of Biomolecular Medicine and Pharmacology, Institute of Pharmacology, Medical University Vienna, A-1090 Vienna, Austria.

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http://dx.doi.org/10.1074/jbc.M109.083154DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2856298PMC
April 2010

Current perspectives on selective dopamine D(3) receptor antagonists as pharmacotherapeutics for addictions and related disorders.

Ann N Y Acad Sci 2010 Feb;1187:4-34

Reckitt Benckiser Pharmaceuticals, Global Research & Development, Richmond, Virginia 23235, USA.

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http://dx.doi.org/10.1111/j.1749-6632.2009.05149.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3148950PMC
February 2010

Dopamine D3 receptors mediate the discriminative stimulus effects of quinpirole in free-feeding rats.

J Pharmacol Exp Ther 2010 Jan 1;332(1):308-15. Epub 2009 Oct 1.

Department of Pharmacology, The University of Texas Health Science Center at San Antonio, TX 78229-3900, USA.

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http://dx.doi.org/10.1124/jpet.109.158394DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2802477PMC
January 2010

The dopamine D3 receptor partial agonist CJB 090 inhibits the discriminative stimulus but not the reinforcing or priming effects of cocaine in squirrel monkeys.

Psychopharmacology (Berl) 2009 Sep 10;206(1):73-84. Epub 2009 Jun 10.

Division of Neuroscience, New England Primate Research Center, Harvard Medical School, One Pine Hill Dr., P.O. Box 9102, Southborough, MA 01772, USA.

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http://link.springer.com/10.1007/s00213-009-1581-9
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http://dx.doi.org/10.1007/s00213-009-1581-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2753862PMC
September 2009

Assessment of reinforcing effects of benztropine analogs and their effects on cocaine self-administration in rats: comparisons with monoamine uptake inhibitors.

J Pharmacol Exp Ther 2009 May 19;329(2):677-86. Epub 2009 Feb 19.

Psychobiology Section, Medications Discovery Research Branch, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Baltimore, MD 21224, USA.

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http://dx.doi.org/10.1124/jpet.108.145813DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2672867PMC
May 2009

A role for dopamine D1-like receptors in acute food deprivation-induced reinstatement of heroin seeking in rats.

Int J Neuropsychopharmacol 2009 Mar 14;12(2):217-26. Epub 2008 Apr 14.

Department of Psychology, Center for Studies in Behavioral Neurobiology, Concordia University, Montreal, Quebec, Canada.

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https://academic.oup.com/ijnp/article-lookup/doi/10.1017/S14
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http://dx.doi.org/10.1017/S1461145708008778DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2678570PMC
March 2009

The novel N-substituted benztropine analog GA2-50 possesses pharmacokinetic and pharmacodynamic profiles favorable for a candidate substitute medication for cocaine abuse.

J Pharm Sci 2008 Dec;97(12):5453-70

Pharmacokinetics-Biopharmaceutics Laboratory, Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland Baltimore, 20 North Pine Street, Baltimore, Maryland 21201, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S002235491632806
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http://dx.doi.org/10.1002/jps.21389DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2673089PMC
December 2008

The effects of two highly selective dopamine D3 receptor antagonists (SB-277011A and NGB-2904) on food self-administration in a rodent model of obesity.

Pharmacol Biochem Behav 2008 Jun 8;89(4):499-507. Epub 2008 Feb 8.

Behavioral Neuropharmacology & Neuroimaging Lab, Department of Medicine, Brookhaven National Laboratory, Upton, NY 11973-5000, USA.

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http://dx.doi.org/10.1016/j.pbb.2008.02.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2681081PMC
June 2008

Population pharmacokinetics, brain distribution, and pharmacodynamics of 2nd generation dopamine transporter selective benztropine analogs developed as potential substitute therapeutics for treatment of cocaine abuse.

J Pharm Sci 2008 May;97(5):1993-2007

Pharmacokinetics and Biopharmaceutics Laboratory, Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, Maryland, USA.

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http://dx.doi.org/10.1002/jps.21123DOI Listing
May 2008

Effects of muscarinic M1 receptor blockade on cocaine-induced elevations of brain dopamine levels and locomotor behavior in rats.

J Pharmacol Exp Ther 2007 Apr 25;321(1):334-44. Epub 2007 Jan 25.

Psychobiology, Department of Health and Human Services, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, USA.

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http://jpet.aspetjournals.org/cgi/doi/10.1124/jpet.106.11806
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http://dx.doi.org/10.1124/jpet.106.118067DOI Listing
April 2007

Transport, metabolism, and in vivo population pharmacokinetics of the chloro benztropine analogs, a class of compounds extensively evaluated in animal models of drug abuse.

J Pharmacol Exp Ther 2007 Jan 26;320(1):344-53. Epub 2006 Sep 26.

Pharmacokinetics-Biopharmaceutics Laboratory, Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland Baltimore, 20 Penn St., HSF-2, Baltimore, MD 21201, USA.

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http://jpet.aspetjournals.org/cgi/doi/10.1124/jpet.106.11124
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http://dx.doi.org/10.1124/jpet.106.111245DOI Listing
January 2007

Investigation of the potential pharmacokinetic and pharmaco-dynamic drug interaction between AHN 1-055, a potent benztropine analog used for cocaine abuse, and cocaine after dosing in rats using intracerebral microdialysis.

Biopharm Drug Dispos 2006 Jul;27(5):229-40

Pharmacokinetics Biopharmaceutics Laboratory, Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, 21201-6808, USA.

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http://dx.doi.org/10.1002/bdd.497DOI Listing
July 2006

Cooperative transcription activation by Nurr1 and Pitx3 induces embryonic stem cell maturation to the midbrain dopamine neuron phenotype.

Proc Natl Acad Sci U S A 2006 Feb 13;103(8):2874-9. Epub 2006 Feb 13.

Department of Pathology and Neurology, Center for Neurobiology and Behavior, and Taub Institute, Columbia University, College of Physicians and Surgeons 15-403, 630 West 168th Street, New York, NY 10032, USA.

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http://www.pnas.org/cgi/doi/10.1073/pnas.0511153103
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http://dx.doi.org/10.1073/pnas.0511153103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1413837PMC
February 2006

Tyr-95 and Ile-172 in transmembrane segments 1 and 3 of human serotonin transporters interact to establish high affinity recognition of antidepressants.

J Biol Chem 2006 Jan 3;281(4):2012-23. Epub 2005 Nov 3.

Department of Pharmacology and Center for Molecular Neuroscience, Vanderbilt University Medical Center, Nashville, TN 37232, USA.

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http://dx.doi.org/10.1074/jbc.M505055200DOI Listing
January 2006

Relationship between in vivo occupancy at the dopamine transporter and behavioral effects of cocaine, GBR 12909 [1-{2-[bis-(4-fluorophenyl)methoxy]ethyl}-4-(3-phenylpropyl)piperazine], and benztropine analogs.

J Pharmacol Exp Ther 2005 Oct 13;315(1):397-404. Epub 2005 Jul 13.

Medication Discovery Research Branch, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Baltimore, MD 21224, USA.

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http://jpet.aspetjournals.org/cgi/doi/10.1124/jpet.105.09123
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http://dx.doi.org/10.1124/jpet.105.091231DOI Listing
October 2005

Dopamine agonist-induced yawning in rats: a dopamine D3 receptor-mediated behavior.

J Pharmacol Exp Ther 2005 Jul 15;314(1):310-9. Epub 2005 Apr 15.

Department of Pharmacology, 1301 MSRB III, University of Michigan Medical School, Ann Arbor, MI 48109-0632, USA.

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http://dx.doi.org/10.1124/jpet.105.085472DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1201434PMC
July 2005

Effects of 4'-chloro-3 alpha-(diphenylmethoxy)-tropane on mesostriatal, mesocortical, and mesolimbic dopamine transmission: comparison with effects of cocaine.

J Pharmacol Exp Ther 2005 May 28;313(2):613-20. Epub 2005 Jan 28.

Psychobiology, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, MD 21224, USA.

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http://dx.doi.org/10.1124/jpet.104.080465DOI Listing
May 2005

Pharmacodynamic assessment of the benztropine analogues AHN-1055 and AHN-2005 using intracerebral microdialysis to evaluate brain dopamine levels and pharmacokinetic/pharmacodynamic modeling.

Pharm Res 2005 Apr 7;22(4):603-12. Epub 2005 Apr 7.

Pharmacokinetics Biopharmaceutics Laboratory, Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, Maryland 21201, USA.

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http://link.springer.com/10.1007/s11095-005-2488-8
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http://dx.doi.org/10.1007/s11095-005-2488-8DOI Listing
April 2005

Synthesis and evaluation of a novel series of 2-chloro-5-((1-methyl-2-(S)-pyrrolidinyl)methoxy)-3-(2-(4-pyridinyl)vinyl)pyridine analogues as potential positron emission tomography imaging agents for nicotinic acetylcholine receptors.

J Med Chem 2002 Jun;45(13):2841-9

Neuroimaging Research Branch and Medicinal Chemistry Section, Intramural Research Program, National Institute on Drug Abuse, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA.

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http://dx.doi.org/10.1021/jm010550nDOI Listing
June 2002