Amy E Dezern

Amy E Dezern

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Amy E Dezern

Amy E Dezern

Publications by authors named "Amy E Dezern"

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Assessing clonal haematopoiesis: clinical burdens and benefits of diagnosing myelodysplastic syndrome precursor states.

Lancet Haematol 2020 Jan 3;7(1):e73-e81. Epub 2019 Dec 3.

Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA. Electronic address:

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http://dx.doi.org/10.1016/S2352-3026(19)30211-XDOI Listing
January 2020

Luspatercept in Patients with Lower-Risk Myelodysplastic Syndromes.

N Engl J Med 2020 01;382(2):140-151

From Service d'Hématologie Séniors, Hôpital Saint-Louis, Assistance Publique-Hôpitaux de Paris and Université Paris 7, Paris (P.F., L.A.), Service des Maladies du Sang, Hôpital Huriez, Centre Hospitalier Universitaire (CHU) de Lille, Lille (B.Q.), the Department of Internal Medicine, CHU Toulouse, Institut Universitaire du Cancer de Toulouse, Toulouse (O.B.-R.), and Université Cote d'Azur, Département d'Hématologie Clinique, CHU Nice, Nice (T.C.) - all in France; Medical Clinic and Policlinic 1, Hematology and Cellular Therapy, Leipzig University Hospital, Leipzig (U.P.), Klinik für Hämatologie, Onkologie, and Klinische Immunologie, Universitätsklinik Düsseldorf, Düsseldorf (U.G.), and Klinik und Poliklinik für Innere Medizin III, Technische Universität München, Munich (K.S.G.) - all in Germany; the Department of Haemato-Oncology, King's College London, London (G.J.M.), Radcliffe Department of Medicine, University of Oxford, John Radcliffe Hospital, Oxford (P.V.), and the Department of Haematology, Leeds Teaching Hospitals NHS Trust, Leeds (D.B.) - all in the United Kingdom; the Department of Leukemia, University of Texas M.D. Anderson Cancer Center, Houston (G.G.-M.); Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto (R.B.); MDS Unit, Azienda Ospedaliero Universitaria Careggi, University of Florence, Florence (V.S.), the Department of Oncology and Hematology, S. Orsola-Malpighi University Hospital, Bologna (C.F.), the University of Pavia, Fondazione IRCCS Policlinico S. Matteo, Pavia (M.C.), the Hematology Unit, Santi Antonio e Biagio e Cesare Arrigo Hospital, Alessandria (F.S., V.G.), and Dipartimento Biomedicina e Prevenzione, University of Rome Tor Vergata, Rome (M.-T.V.) - all in Italy; the Hematology Department, University Hospital of Salamanca, Institute of Biomedical Research of Salamanca, Salamanca (M.D.-C.), Unidad de Hematología, Hospital Universitario Virgen del Rocío, Seville (J.F.F.), and the Department of Hematology, Hospital Universitario Cruces, Vizcaya (B.A.) - all in Spain; the Department of Hematology Science, School of Medicine, Ankara University, Ankara, Turkey (O.I.); the Department of Hematology and Medical Oncology, Cleveland Clinic, Cleveland (M.A.S.); the Department of Hematology, Algemeen Ziekenhuis Sint-Jan, Bruges (D.S.), and Universitair Ziekenhuis Gent, Ghent (D.M.) - both in Belgium; the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore (A.E.D.); the Division of Hematology-Oncology, Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center (J.G.J.), and Albert Einstein College of Medicine (A.V.) - both in New York; the Department of Hematology, University Medical Center of Groningen, University of Groningen, Groningen, the Netherlands (E.V.); Stanford University Cancer Center, Stanford, CA (P.L.G.); the Center for Hematology and Regenerative Medicine, Department of Medicine, Karolinska Institutet, Stockholm (E.H.-L.); the Department of Internal Medicine, Yale School of Medicine, Yale University, New Haven, CT (A.M.Z.); Vanderbilt University School of Medicine, Vanderbilt-Ingram Cancer Center, Nashville (M.R.S.); Celgene, Summit, NJ (A.L., J.Z., A.R., D.R.D.); Celgene International, Boudry, Switzerland (A.B.); Acceleron Pharma, Cambridge, MA (P.G.L., M.L.S.); and Moffitt Cancer Center, Tampa, FL (R.S.K., A.F.L.).

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http://dx.doi.org/10.1056/NEJMoa1908892DOI Listing
January 2020

One-unit compared to two-unit platelet transfusions for adult oncology outpatients.

Vox Sang 2019 Jul 5;114(5):517-522. Epub 2019 May 5.

Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

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http://dx.doi.org/10.1111/vox.12785DOI Listing
July 2019

Chronic Myelomonocytic Leukemia: 2018 Update to Prognosis and Treatment.

Curr Hematol Malig Rep 2019 Jun;14(3):154-163

Division of Hematologic Malignancies, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.

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http://dx.doi.org/10.1007/s11899-019-00509-9DOI Listing
June 2019

CHIP, CCUS, and Other Acronyms: Definition, Implications, and Impact on Practice.

Am Soc Clin Oncol Educ Book 2019 Jan 17;39:400-410. Epub 2019 May 17.

3 Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA.

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https://ascopubs.org/doi/10.1200/EDBK_239083
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http://dx.doi.org/10.1200/EDBK_239083DOI Listing
January 2019

Eculizumab Bridging before Bone Marrow Transplant for Marrow Failure Disorders Is Safe and Does Not Limit Engraftment.

Biol Blood Marrow Transplant 2018 12 26;24(12):e26-e30. Epub 2018 Jul 26.

Department of Oncology, Sidney Kimmel Cancer Center, Baltimore Maryland; Department of Medicine, Division of Hematology, Johns Hopkins University, Baltimore, Maryland.

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http://dx.doi.org/10.1016/j.bbmt.2018.07.032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6286212PMC
December 2018

Low clinical trial accrual of patients with myelodysplastic syndromes: Causes and potential solutions.

Cancer 2018 12 5;124(24):4601-4609. Epub 2018 Oct 5.

Department of Hematology and Medical Oncology, Cleveland Clinic Taussig Cancer Institute, Cleveland, Ohio.

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http://doi.wiley.com/10.1002/cncr.31769
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http://dx.doi.org/10.1002/cncr.31769DOI Listing
December 2018

Treatments targeting MDS genetics: a fool's errand?

Authors:
Amy E DeZern

Hematology Am Soc Hematol Educ Program 2018 11;2018(1):277-285

Division of Hematologic Malignancies, John Hopkins Medicine, Baltimore, MD.

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http://dx.doi.org/10.1182/asheducation-2018.1.277DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6246001PMC
November 2018

Haploidentical Donor Bone Marrow Transplantation for Severe Aplastic Anemia.

Hematol Oncol Clin North Am 2018 Aug 28;32(4):629-642. Epub 2018 May 28.

Division of Hematology, The Johns Hopkins University School of Medicine, 720 Rutland Avenue, Ross 1025, Baltimore, MD 21205, USA.

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http://dx.doi.org/10.1016/j.hoc.2018.04.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6063510PMC
August 2018

Diagnostic utility of telomere length testing in a hospital-based setting.

Proc Natl Acad Sci U S A 2018 03 20;115(10):E2358-E2365. Epub 2018 Feb 20.

Department of Oncology and Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, MD 21287;

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http://dx.doi.org/10.1073/pnas.1720427115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5877993PMC
March 2018

ICCS/ESCCA consensus guidelines to detect GPI-deficient cells in paroxysmal nocturnal hemoglobinuria (PNH) and related disorders part 1 - clinical utility.

Cytometry B Clin Cytom 2018 01;94(1):16-22

Department of Oncology, Johns Hopkins Medical Institutions, Baltimore, Maryland.

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http://dx.doi.org/10.1002/cyto.b.21608DOI Listing
January 2018

Relationship between lenalidomide dose modification, duration of therapy, and long-term outcomes in patients with myelodysplastic syndromes.

Leuk Res 2017 12 18;63:10-14. Epub 2017 Oct 18.

The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, 1650 Orleans Street, CRB1 Room 3M87, Baltimore, MD 21231, USA. Electronic address:

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http://dx.doi.org/10.1016/j.leukres.2017.10.005DOI Listing
December 2017

Patterns of treatment and costs associated with transfusion burden in patients with myelodysplastic syndromes.

Leuk Lymphoma 2017 11 9;58(11):2649-2656. Epub 2017 May 9.

a Sidney Kimmel Comprehensive Cancer Center , Johns Hopkins University , Baltimore , MD , USA.

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http://dx.doi.org/10.1080/10428194.2017.1312372DOI Listing
November 2017

Single-Nucleotide Polymorphism Leading to False Allelic Fraction by Droplet Digital PCR.

Clin Chem 2017 Aug 14;63(8):1370-1376. Epub 2017 Jun 14.

The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD;

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http://dx.doi.org/10.1373/clinchem.2017.273177DOI Listing
August 2017

Meaningful endpoints for therapies approved for hematologic malignancies.

Cancer 2017 05 21;123(10):1689-1694. Epub 2017 Feb 21.

Cedars-Sinai Samuel Oschin Comprehensive Cancer Institute, Los Angeles, California.

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http://dx.doi.org/10.1002/cncr.30622DOI Listing
May 2017

Paroxysmal nocturnal haemoglobinuria.

Nat Rev Dis Primers 2017 05 18;3:17028. Epub 2017 May 18.

Division of Hematology, Johns Hopkins Department of Medicine, Johns Hopkins University, Ross Research Building, Room 1025, 720 Rutland Avenue, Baltimore, Maryland 21205, USA.

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http://dx.doi.org/10.1038/nrdp.2017.28DOI Listing
May 2017

Alternative Donor Transplantation with High-Dose Post-Transplantation Cyclophosphamide for Refractory Severe Aplastic Anemia.

Biol Blood Marrow Transplant 2017 Mar 21;23(3):498-504. Epub 2016 Dec 21.

Department of Oncology, Sidney Kimmel Cancer Center, Baltimore, Maryland; Department of Medicine, Division of Hematology, Johns Hopkins University, Baltimore, Maryland.

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http://dx.doi.org/10.1016/j.bbmt.2016.12.628DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5373094PMC
March 2017

High-dose Cyclophosphamide is Effective Therapy for Pediatric Severe Aplastic Anemia.

J Pediatr Hematol Oncol 2016 11;38(8):627-635

Departments of *Oncology, Division of Pediatric Oncology †Pediatrics, The Division of Hematology ‡Medicine, The Division of Hematology §Pathology, The Division of Transfusion Medicine ¶The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Johns Hopkins University School of Medicine, Baltimore, MD ∥Department of Pathology and Lab Medicine, The Division of Transfusion Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5074865PMC
http://dx.doi.org/10.1097/MPH.0000000000000647DOI Listing
November 2016

Genetic panels in young patients with bone marrow failure: are they clinically relevant?

Haematologica 2016 11;101(11):1275-1276

Division of Hematology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

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http://dx.doi.org/10.3324/haematol.2016.152389DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5394880PMC
November 2016

Nine years without a new FDA-approved therapy for MDS: how can we break through the impasse?

Authors:
Amy E DeZern

Hematology Am Soc Hematol Educ Program 2015 ;2015:308-16

Division of Hematologic Malignancies, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD.

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http://dx.doi.org/10.1182/asheducation-2015.1.308DOI Listing
October 2016

Do somatic mutations in de novo MDS predict for response to treatment?

Hematology Am Soc Hematol Educ Program 2015 ;2015:317-28

The Johns Hopkins University School of Medicine, Baltimore, MD.

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http://dx.doi.org/10.1182/asheducation-2015.1.317DOI Listing
October 2016

Loss-of-function mutations in the RNA biogenesis factor NAF1 predispose to pulmonary fibrosis-emphysema.

Sci Transl Med 2016 08;8(351):351ra107

Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA. Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA. McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.

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http://dx.doi.org/10.1126/scitranslmed.aaf7837DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5351811PMC
August 2016

Red blood cell transfusion triggers in acute leukemia: a randomized pilot study.

Transfusion 2016 07 20;56(7):1750-7. Epub 2016 May 20.

Division of Transfusion Medicine, Department of Pathology, The Johns Hopkins School of Medicine, Baltimore, Maryland.

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http://dx.doi.org/10.1111/trf.13658DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4986514PMC
July 2016

Alternative-Donor Hematopoietic Stem Cell Transplantation with Post-Transplantation Cyclophosphamide for Nonmalignant Disorders.

Biol Blood Marrow Transplant 2016 May 6;22(5):895-901. Epub 2016 Feb 6.

Pediatric Blood and Marrow Transplantation Program, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins Hospital, Baltimore, Maryland.

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http://dx.doi.org/10.1016/j.bbmt.2016.02.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4898048PMC
May 2016

Hepatopulmonary syndrome is a frequent cause of dyspnea in the short telomere disorders.

Chest 2015 Oct;148(4):1019-1026

Department of Oncology, Baltimore, MD; Department of Pathology, Baltimore, MD; McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD. Electronic address:

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http://dx.doi.org/10.1378/chest.15-0825DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4594621PMC
October 2015

Paroxysmal nocturnal hemoglobinuria: a complement-mediated hemolytic anemia.

Hematol Oncol Clin North Am 2015 Jun 7;29(3):479-94. Epub 2015 Mar 7.

Division of Hematology, The Johns Hopkins University School of Medicine, 720 Rutland Avenue, Ross Research Building, Room 1025, Baltimore, MD 21205, USA.

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http://dx.doi.org/10.1016/j.hoc.2015.01.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4695989PMC
June 2015

Myelodysplastic syndromes, version 2.2015.

J Natl Compr Canc Netw 2015 Mar;13(3):261-72

From Stanford Cancer Institute; Dana-Farber/Brigham and Women's Cancer Center; UC San Diego Moores Cancer Center; University of Rochester Medical Center; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; University of Alabama at Birmingham Comprehensive Cancer Center; Duke Cancer Institute; Fred Hutchinson Cancer Research Center/Seattle Cancer Care Alliance; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; Massachusetts General Hospital Cancer Center; Robert H. Lurie Comprehensive Cancer Center of Northwestern University; UCSF Helen Diller Family Comprehensive Cancer Center; The University of Texas MD Anderson Cancer Center; Roswell Park Cancer Institute; Vanderbilt-Ingram Cancer Center; Memorial Sloan Kettering Cancer Center; Moffitt Cancer Center; University of Michigan Comprehensive Cancer Center; Fred & Pamela Buffett Cancer Center; City of Hope Comprehensive Cancer Center; University of Colorado Cancer Center; Huntsman Cancer Institute at the University of Utah; Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; and National Comprehensive Cancer Network.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4696005PMC
http://dx.doi.org/10.6004/jnccn.2015.0038DOI Listing
March 2015

I walk the line: how to tell MDS from other bone marrow failure conditions.

Curr Hematol Malig Rep 2014 Dec;9(4):389-99

Department of Oncology, Division of Hematological Malignancies, Johns Hopkins University, 1650 Orleans St, CRB1-290, Baltimore, MD, 21231, USA,

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http://dx.doi.org/10.1007/s11899-014-0224-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4224968PMC
December 2014

Aplastic anemia in adolescents and young adults.

Acta Haematol 2014 10;132(3-4):331-9. Epub 2014 Sep 10.

Johns Hopkins University School of Medicine, Baltimore, Md., USA.

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http://dx.doi.org/10.1159/000360209DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4183226PMC
November 2014

Risk-adjusted clinical outcomes in patients enrolled in a bloodless program.

Transfusion 2014 Oct 18;54(10 Pt 2):2668-77. Epub 2014 Jun 18.

Department of Anesthesiology/Critical Care Medicine, The Johns Hopkins Medical Institutions, Baltimore, Maryland.

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http://dx.doi.org/10.1111/trf.12752DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4234090PMC
October 2014

Complement blockade with a C1 esterase inhibitor in paroxysmal nocturnal hemoglobinuria.

Exp Hematol 2014 Oct 14;42(10):857-61.e1. Epub 2014 Jul 14.

The Sidney Kimmel Cancer Center at Johns Hopkins, Baltimore, MD, USA; Division of Hematology, Department of Medicine, The Johns Hopkins School of Medicine, Baltimore, MD, USA. Electronic address:

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http://dx.doi.org/10.1016/j.exphem.2014.06.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4250431PMC
October 2014

The challenging world of cytopenias: distinguishing myelodysplastic syndromes from other disorders of marrow failure.

Oncologist 2014 Jul 4;19(7):735-45. Epub 2014 Jun 4.

The Sidney Kimmel Comprehensive Cancer Center and Division of Hematology, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA; Leukemia Program, Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio, USA.

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http://theoncologist.alphamedpress.org/lookup/doi/10.1634/th
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http://dx.doi.org/10.1634/theoncologist.2014-0056DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4077450PMC
July 2014

Detection of paroxysmal nocturnal hemoglobinuria clones to exclude inherited bone marrow failure syndromes.

Eur J Haematol 2014 Jun 18;92(6):467-70. Epub 2014 Mar 18.

The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, The Johns Hopkins University School of Medicine, Baltimore, MD, USA; Division of Hematology, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.

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http://dx.doi.org/10.1111/ejh.12299DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4161035PMC
June 2014

Burst-forming unit-erythroid assays to distinguish cellular bone marrow failure disorders.

Exp Hematol 2013 Sep 6;41(9):808-16. Epub 2013 May 6.

The Sidney Kimmel Cancer Center at Johns Hopkins, Baltimore, Maryland 21287, USA.

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http://dx.doi.org/10.1016/j.exphem.2013.04.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3769493PMC
September 2013

Predictors of hemoglobin response to eculizumab therapy in paroxysmal nocturnal hemoglobinuria.

Eur J Haematol 2013 Jan 22;90(1):16-24. Epub 2012 Nov 22.

Division of Hematology, Department of Medicine, The Johns Hopkins School of Medicine, Baltimore, MD, USA.

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http://dx.doi.org/10.1111/ejh.12021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3673783PMC
January 2013

Repeated treatment with high dose cyclophosphamide for severe autoimmune diseases.

Am J Blood Res 2013 17;3(1):84-90. Epub 2013 Jan 17.

Division of Hematologic Malignancies, Department of Medical Oncology, The Johns Hopkins School of Medicine Baltimore, MD, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3555191PMC
January 2013

Therapy for aplastic anemia.

Hematology Am Soc Hematol Educ Program 2011 ;2011:82-3

Department of Oncology, Johns Hopkins University, Baltimore, MD 21205, USA.

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http://dx.doi.org/10.1182/asheducation-2011.1.82DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4138693PMC
April 2012

Clinical management of aplastic anemia.

Expert Rev Hematol 2011 Apr;4(2):221-30

Division of Medical Oncology, Department of Medicine, The Johns Hopkins School of Medicine, 720 Rutland Avenue, Baltimore, MD 21205, USA.

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http://dx.doi.org/10.1586/ehm.11.11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3138728PMC
April 2011