Publications by authors named "Amy A Hassan"

3 Publications

  • Page 1 of 1

Diffuse Large B-Cell Lymphoma at the Site of a Herpes Zoster Scar.

World J Oncol 2012 Aug 26;3(4):199-203. Epub 2012 Aug 26.

Depts of Dermatology, MD Anderson Cancer Center and University of Texas Medical School at Houston, Houston, Texas; 6655 Travis Street, Suite 980 Houston, Texas 77030, USA.

Herpes zoster, also known as shingles, occurs upon reactivation of a primary infection with varicella zoster virus (VZV). Risk factors for reactivation include stress, older age, and immunosuppression, all of which are associated with a decrease in host immunity. Common complications of herpes zoster include scarring and post-herpetic neuralgia (PHN). Cutaneous lesions such as granuloma annulare, lymphomas, and sarcoid granulomas have also been reported to potentially arise at the site of herpes zoster. Here, we report a case that to our knowledge is the first presentation of diffuse large B-cell lymphoma with its only cutaneous manifestation arising in a herpes zoster scar. Punch biopsy was performed on a nodule appearing in a dermatomal distribution within the herpes zoster scar. Histopathology revealed an atypical lymphoid infiltrate in the dermis that was determined to be CD20 positive B-cells. Immunostains for CD20, CD79a, and PAX-5 showed strong positive staining of the atypical cells, confirming B-cell origin and resulting in the diagnosis of lymphoma, large B-cell type. This case highlights the importance of raising clinical suspicion for a malignant process in patients who present with a changing or unresolving skin manifestation after infection with varicella zoster virus.
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http://dx.doi.org/10.4021/wjon531wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5649845PMC
August 2012

Serine-derivatized gadonanotubes as magnetic nanoprobes for intracellular labeling.

Contrast Media Mol Imaging 2010 Jan-Feb;5(1):34-8

Breast Center, Department of Medicine and Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA.

Gadonanotubes (GNTs), which are powerful new T(1)-weighted MRI contrast agents, were derivatized with serine amino acid substituents to produce water-soluble (2 mg ml(-1)) ser-gadonanotubes (ser-GNs) as magnetic nanoprobes for intracellular labeling. The ser-GNTs were used to efficiently label MCF-7 human breast cancer cells (1.5 x 10(9) Gd(3+) ions/cell) with no observable cytotoxicity. Cell pellets derived from the ser-GNT labeled cells give bright T(1)-weighted MR images, confirming that the ser-GNTs are a promising new nanoprobe technology for magnetic cell labeling and possibly for in vivo cellular trafficking.
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http://dx.doi.org/10.1002/cmmi.293DOI Listing
August 2010

Acquired disorders of platelet function.

Hematology Am Soc Hematol Educ Program 2005 :403-8

Thrombosis Research, Michael E DeBakey VA Medical Center, 2002 Holcombe Blvd., Houston, TX 77030, USA.

A qualitative abnormality of platelet function should be considered in patients with mucocutaneous bleeding in the absence of thrombocytopenia or von Willebrand disease. Antiplatelet drugs are the most common cause of acquired platelet disorders leading to bleeding. Uremia, hepatic cirrhosis, myeloma and related disorders, polycythemia vera, essential thrombocythemia, and cardiopulmonary bypass have long been recognized as clinical situations in which platelet dysfunction may contribute to bleeding. When an acquired platelet disorder is suspected, it is useful to examine platelet function by measuring the bleeding time, examining platelet-dependent closure time in a platelet function analyzer and performing platelet aggregometry. When a specific acquired platelet disorder is diagnosed, many treatment options are available including controlling the underlying disease, giving platelet transfusions and administering a hemostatic drug.
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http://dx.doi.org/10.1182/asheducation-2005.1.403DOI Listing
November 2009