Amr M Ghaleb

Amr M Ghaleb

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Amr M Ghaleb

Amr M Ghaleb

Publications by authors named "Amr M Ghaleb"

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Murine Model for Colitis-Associated Cancer of the Colon.

Methods Mol Biol 2016 ;1438:245-54

Department of Medicine, Stony Brook University, Stony Brook, NY, 11794, USA.

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http://dx.doi.org/10.1007/978-1-4939-3661-8_14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5657253PMC
December 2017

Kruppel-like factor 4 regulates matrix metalloproteinase and aggrecanase gene expression in chondrocytes.

Cell Tissue Res 2017 12 31;370(3):441-449. Epub 2017 Aug 31.

Department of Oral Anatomy and Developmental Biology, Osaka University Graduate School of Dentistry, 1-8 Yamada-oka, Suita, Osaka, 565-0871, Japan.

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http://link.springer.com/10.1007/s00441-017-2674-0
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http://dx.doi.org/10.1007/s00441-017-2674-0DOI Listing
December 2017

Krüppel-like factor 4 (KLF4): What we currently know.

Gene 2017 May 22;611:27-37. Epub 2017 Feb 22.

Department of Medicine, Stony Brook University, Stony Brook, NY 11794, USA; Department of Physiology and Biophysics, Stony Brook University, Stony Brook, NY 11794, USA. Electronic address:

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http://dx.doi.org/10.1016/j.gene.2017.02.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5391259PMC
May 2017

Improved Swiss-rolling Technique for Intestinal Tissue Preparation for Immunohistochemical and Immunofluorescent Analyses.

J Vis Exp 2016 07 13(113). Epub 2016 Jul 13.

Department of Medicine, Stony Brook University School of Medicine; Department of Physiology & Biophysics, Stony Brook University School of Medicine;

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http://dx.doi.org/10.3791/54161DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4993444PMC
July 2016

Krüppel-like Factor 4 Modulates Development of BMI1(+) Intestinal Stem Cell-Derived Lineage Following γ-Radiation-Induced Gut Injury in Mice.

Stem Cell Reports 2016 06 26;6(6):815-824. Epub 2016 May 26.

Department of Medicine, Stony Brook University, Stony Brook, NY 11794, USA; Stony Brook University Medical Center, HSC T-16, Room 020, Stony Brook, NY 11794-8160, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stemcr.2016.04.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4911500PMC
June 2016

KLF4 Suppresses Tumor Formation in Genetic and Pharmacological Mouse Models of Colonic Tumorigenesis.

Mol Cancer Res 2016 Apr 2;14(4):385-96. Epub 2016 Feb 2.

Department of Medicine, Stony Brook University, Stony Brook, New York. Department of Physiology and Biophysics, Stony Brook University, Stony Brook, New York.

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http://dx.doi.org/10.1158/1541-7786.MCR-15-0410DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4834227PMC
April 2016

Distinct roles for hematopoietic and extra-hematopoietic sphingosine kinase-1 in inflammatory bowel disease.

PLoS One 2014 2;9(12):e113998. Epub 2014 Dec 2.

Northport Veterans Affairs Medical Center, Northport, New York, United States of America; Department of Medicine, Stony Brook University, Stony Brook, New York, United States of America; Stony Brook Cancer Center, Stony Brook University, Stony Brook, New York, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0113998PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4252067PMC
August 2015

Krüppel-like factor 4 is a radioprotective factor for the intestine following γ-radiation-induced gut injury in mice.

Am J Physiol Gastrointest Liver Physiol 2015 Jan 20;308(2):G121-38. Epub 2014 Nov 20.

Department of Medicine, Stony Brook University, Stony Brook, New York; and

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http://dx.doi.org/10.1152/ajpgi.00080.2014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4297857PMC
January 2015

Krüppel-like factor 5 is essential for proliferation and survival of mouse intestinal epithelial stem cells.

Stem Cell Res 2015 Jan 6;14(1):10-9. Epub 2014 Nov 6.

Department of Medicine, Stony Brook University School of Medicine, HSC-T16 Room 020, Stony Brook, NY 11794, United States. Electronic address:

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http://dx.doi.org/10.1016/j.scr.2014.10.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4310780PMC
January 2015

Role of Krüppel-like factor 5 in the maintenance of the stem cell niche in the intestinal crypt.

Stem Cell Transl Investig 2015;2(2)

Department of Medicine, Stony Brook University School of Medicine, HSC-T16 Room 020, Stony Brook, NY 11794, United States ; Department of Physiology and Biophysics, Stony Brook University School of Medicine, HSC-T16 Room 020, Stony Brook, NY 11794, United States.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4474380PMC
January 2015

Genetic deletion of Klf4 in the mouse intestinal epithelium ameliorates dextran sodium sulfate-induced colitis by modulating the NF-κB pathway inflammatory response.

Inflamm Bowel Dis 2014 May;20(5):811-20

*Department of Medicine, Stony Brook University, Stony Brook, New York; †Department of Biology and Chemistry, Center for Diagnostics and Therapeutics, Georgia State University, Atlanta, Georgia; and ‡Veterans Affairs Medical Center, Decatur, GA.

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http://dx.doi.org/10.1097/MIB.0000000000000022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4091934PMC
May 2014

Inducible intestine-specific deletion of Krüppel-like factor 5 is characterized by a regenerative response in adult mouse colon.

Dev Biol 2014 Mar 15;387(2):191-202. Epub 2014 Jan 15.

Department of Medicine, Stony Brook University School of Medicine, HSC-T16 Room 020, Stony Brook, NY 11794, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ydbio.2014.01.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3949508PMC
March 2014

Krüppel-like factor 4 regulates genetic stability in mouse embryonic fibroblasts.

Mol Cancer 2013 Aug 6;12:89. Epub 2013 Aug 6.

Department of Medicine, Stony Brook University, Stony Brook, NY 11794, USA.

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http://dx.doi.org/10.1186/1476-4598-12-89DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3750599PMC
August 2013

Chemoprevention of familial adenomatous polyposis by bromo-noscapine (EM011) in the Apc(Min/+) mouse model.

Int J Cancer 2012 Sep 9;131(6):1435-44. Epub 2012 Feb 9.

Department of Cell Biology, Emory University School of Medicine, Atlanta, GA 30322, USA.

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http://dx.doi.org/10.1002/ijc.27344DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3362662PMC
September 2012

Notch1 regulates the effects of matrix metalloproteinase-9 on colitis-associated cancer in mice.

Gastroenterology 2011 Oct 30;141(4):1381-92. Epub 2011 Jun 30.

Division of Digestive Diseases, Department of Pathology, Emory University School of Medicine, Atlanta, Georgia 30322, USA.

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http://dx.doi.org/10.1053/j.gastro.2011.06.056DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3186860PMC
October 2011

Krüppel-like factor 5 is important for maintenance of crypt architecture and barrier function in mouse intestine.

Gastroenterology 2011 Oct 18;141(4):1302-13, 1313.e1-6. Epub 2011 Jul 18.

Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA.

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http://dx.doi.org/10.1053/j.gastro.2011.06.086DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3186863PMC
October 2011

Altered intestinal epithelial homeostasis in mice with intestine-specific deletion of the Krüppel-like factor 4 gene.

Dev Biol 2011 Jan 9;349(2):310-20. Epub 2010 Nov 9.

Division of Digestive Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA.

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http://dx.doi.org/10.1016/j.ydbio.2010.11.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3022386PMC
January 2011

Expression profiling and pathway analysis of Krüppel-like factor 4 in mouse embryonic fibroblasts.

Am J Cancer Res 2011 Jan;1(1):85-97

Division of Digestive Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3165197PMC
January 2011

Expression of the tumor suppressor Krüppel-like factor 4 as a prognostic predictor for colon cancer.

Cancer Epidemiol Biomarkers Prev 2010 Oct 10;19(10):2631-8. Epub 2010 Aug 10.

Division of Digestive Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA.

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http://dx.doi.org/10.1158/1055-9965.EPI-10-0677DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2952064PMC
October 2010

Krüppel-like factor 5 is a crucial mediator of intestinal tumorigenesis in mice harboring combined ApcMin and KRASV12 mutations.

Mol Cancer 2010 Mar 18;9:63. Epub 2010 Mar 18.

Division of Digestive Diseases, Department of Medicine, Emory University School of Medicine, 201 Whitehead Research Building, 615 Michael Street, Atlanta, GA 30322, USA.

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http://dx.doi.org/10.1186/1476-4598-9-63DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2856552PMC
March 2010

The absence of LPA2 attenuates tumor formation in an experimental model of colitis-associated cancer.

Gastroenterology 2009 May 9;136(5):1711-20. Epub 2009 Jan 9.

Division of Digestive Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, USA.

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http://dx.doi.org/10.1053/j.gastro.2009.01.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2691721PMC
May 2009

Haploinsufficiency of Krüppel-like factor 5 rescues the tumor-initiating effect of the Apc(Min) mutation in the intestine.

Cancer Res 2009 May 12;69(10):4125-33. Epub 2009 May 12.

Division of Digestive Diseases, Department of Medicine, Department of Pharmacology, and Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA 30322, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-08-4402DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2702486PMC
May 2009

Notch inhibits expression of the Krüppel-like factor 4 tumor suppressor in the intestinal epithelium.

Mol Cancer Res 2008 Dec;6(12):1920-7

Division of Digestive Diseases, Department of Medicine, Emory University School of Medicine, 615 Michael Street, Atlanta, GA 30322, USA.

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http://dx.doi.org/10.1158/1541-7786.MCR-08-0224DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2628949PMC
December 2008

Krüppel-like factor 5 mediates cellular transformation during oncogenic KRAS-induced intestinal tumorigenesis.

Gastroenterology 2008 Jan 17;134(1):120-30. Epub 2007 Oct 17.

Division of Digestive Diseases, Department of Medicine, Emory University, Atlanta, Georgia, USA.

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http://dx.doi.org/10.1053/j.gastro.2007.10.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2194652PMC
January 2008

Haploinsufficiency of Krüppel-like factor 4 promotes adenomatous polyposis coli dependent intestinal tumorigenesis.

Cancer Res 2007 Aug;67(15):7147-54

Division of Digestive Diseases, Department of Medicine, and Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia 30033, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-07-1302DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2373271PMC
August 2007

The diverse functions of Krüppel-like factors 4 and 5 in epithelial biology and pathobiology.

Bioessays 2007 Jun;29(6):549-57

Division of Digestive Diseases, Department of Medicine, Emory University School of Medicine, 615 Michael Street, Atlanta, GA 30322, USA.

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http://dx.doi.org/10.1002/bies.20581DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2211634PMC
June 2007

p53 and p21 determine the sensitivity of noscapine-induced apoptosis in colon cancer cells.

Cancer Res 2007 Apr;67(8):3862-70

Department of Cell Biology and Division of Digestive Diseases, Emory University School of Medicine, 615 Michael Street, Atlanta, GA 30322, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-06-4282DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3757339PMC
April 2007

Transcriptional profiling of the cell cycle checkpoint gene krüppel-like factor 4 reveals a global inhibitory function in macromolecular biosynthesis.

Gene Expr 2006 ;13(2):85-96

Division of Digestive Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1626270PMC
http://dx.doi.org/10.3727/000000006783991908DOI Listing
October 2006

A 3 kDa peptide is involved in the chemoattraction in vitro of the male Schistosoma mansoni to the female.

Microbes Infect 2006 Aug 3;8(9-10):2367-75. Epub 2006 Jul 3.

Division of Digestive Diseases, R275, WBRB, Emory University School of Medicine, 615 Michael St., Atlanta, GA 30322, USA.

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http://dx.doi.org/10.1016/j.micinf.2006.04.024DOI Listing
August 2006

Krüppel-like factor 4 prevents centrosome amplification following gamma-irradiation-induced DNA damage.

Oncogene 2005 Jun;24(25):4017-25

Division of Digestive Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA.

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http://dx.doi.org/10.1038/sj.onc.1208576DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1626272PMC
June 2005

Krüppel-like factors 4 and 5: the yin and yang regulators of cellular proliferation.

Cell Res 2005 Feb;15(2):92-6

Division of Digestive Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA.

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http://dx.doi.org/10.1038/sj.cr.7290271DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1317089PMC
February 2005