Amita Sehgal

Amita Sehgal

UNVERIFIED PROFILE

Are you Amita Sehgal?   Register this Author

Register author
Amita Sehgal

Amita Sehgal

Publications by authors named "Amita Sehgal"

Are you Amita Sehgal?   Register this Author

99Publications

1468Reads

25Profile Views

Altered ocular parameters from circadian clock gene disruptions.

PLoS One 2019 18;14(6):e0217111. Epub 2019 Jun 18.

Center for Visual and Neurocognitive Rehabilitation, Atlanta VA Medical Center, Decatur, Georgia, United States of America.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0217111PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6581257PMC
February 2020

RNA Splicing Factor Mutations That Cause Retinitis Pigmentosa Result in Circadian Dysregulation.

J Biol Rhythms 2020 Feb 15;35(1):72-83. Epub 2019 Nov 15.

Chronobiology and Sleep institute (CSI) and Howard Hughes Medical Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/0748730419887876DOI Listing
February 2020

The Glial Perspective on Sleep and Circadian Rhythms.

Annu Rev Neurosci 2020 Feb 19. Epub 2020 Feb 19.

Chronobiology and Sleep Institute, Perelman School of Medicine, and Howard Hughes Medical Institute, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA; email:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1146/annurev-neuro-091819-094557DOI Listing
February 2020

Molecular and circuit mechanisms mediating circadian clock output in the Drosophila brain.

Eur J Neurosci 2020 Jan 16;51(1):268-281. Epub 2018 Aug 16.

Department of Neuroscience, Perelman School of Medicine, Howard Hughes Medical Institute, University of Pennsylvania, Philadelphia, Pennsylvania.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/ejn.14092DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6353709PMC
January 2020

Splicing the Clock to Maintain and Entrain Circadian Rhythms.

J Biol Rhythms 2019 Dec 7;34(6):584-595. Epub 2019 Aug 7.

Howard Hughes Medical Institute, University of Pennsylvania, Philadelphia, Pennsylvania.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/0748730419868136DOI Listing
December 2019

Misregulation of Drosophila Myc Disrupts Circadian Behavior and Metabolism.

Cell Rep 2019 Nov;29(7):1778-1788.e4

Ludwig Institute for Cancer Research, New York, NY 10017, USA; The Wistar Institute, Philadelphia, PA 19104, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.celrep.2019.10.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6910219PMC
November 2019

Wolbachia affects sleep behavior in Drosophila melanogaster.

J Insect Physiol 2018 May - Jun;107:81-88. Epub 2018 Feb 27.

School of Life Sciences, Hubei Key Laboratory of Genetic Regulation and Integrative Biology, Central China Normal University, Wuhan 430079, PR China. Electronic address:

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S00221910173039
Publisher Site
http://dx.doi.org/10.1016/j.jinsphys.2018.02.011DOI Listing
September 2019

The NRON complex controls circadian clock function through regulated PER and CRY nuclear translocation.

Sci Rep 2019 Aug 15;9(1):11883. Epub 2019 Aug 15.

Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41598-019-48341-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6695496PMC
August 2019

Regulation of the Blood-Brain Barrier by Circadian Rhythms and Sleep.

Trends Neurosci 2019 Jul;42(7):500-510

Center for Sleep and Circadian Neurobiology, Chronobiology Program, and Howard Hughes Medical Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.tins.2019.05.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6602072PMC
July 2019

Genetic Mechanisms Underlying Sleep.

Cold Spring Harb Symp Quant Biol 2018 1;83:57-61. Epub 2019 Apr 1.

Howard Hughes Medical Institute, Perelman School of Medicine University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1101/sqb.2018.83.037705DOI Listing
April 2019

G1/S cell cycle regulators mediate effects of circadian dysregulation on tumor growth and provide targets for timed anticancer treatment.

PLoS Biol 2019 04 30;17(4):e3000228. Epub 2019 Apr 30.

Penn Chronobiology, Howard Hughes Medical Institute, Department of Neuroscience, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America.

View Article

Download full-text PDF

Source
http://dx.plos.org/10.1371/journal.pbio.3000228
Publisher Site
http://dx.doi.org/10.1371/journal.pbio.3000228DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6490878PMC
April 2019

A sleep-inducing gene, , links sleep and immune function in .

Science 2019 02;363(6426):509-515

Howard Hughes Medical Institute, Chronobiology Program, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1126/science.aat1650DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6505470PMC
February 2019

Spliceosome factors target timeless () mRNA to control clock protein accumulation and circadian behavior in Drosophila.

Elife 2018 12 5;7. Epub 2018 Dec 5.

Chronobiology Program at Penn, Howard Hughes Medical Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7554/eLife.39821DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6281371PMC
December 2018

Circadian and Sleep Circuits Ring Together.

Neuron 2018 11;100(3):514-516

Penn Chronobiology, Howard Hughes Medical Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. Electronic address:

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S08966273183093
Publisher Site
http://dx.doi.org/10.1016/j.neuron.2018.10.030DOI Listing
November 2018

Endocytosis at the blood-brain barrier as a function for sleep.

Elife 2018 11 26;7. Epub 2018 Nov 26.

Neuroscience Graduate Group, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States.

View Article

Download full-text PDF

Source
https://elifesciences.org/articles/43326
Publisher Site
http://dx.doi.org/10.7554/eLife.43326DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6255390PMC
November 2018

Asymmetric vasopressin signaling spatially organizes the master circadian clock.

J Comp Neurol 2018 09 22;526(13):2048-2067. Epub 2018 Aug 22.

Department of Biomedical Sciences, Marquette University, Milwaukee, WI, 53233.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/cne.24478DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6158041PMC
September 2018

Cold Temperatures Fire up Circadian Neurons.

Cell Metab 2018 May;27(5):951-953

Howard Hughes Medical Institute, University of Pennsylvania, Philadelphia, PA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cmet.2018.04.016DOI Listing
May 2018

Circadian- and Light-driven Metabolic Rhythms in Drosophila melanogaster.

J Biol Rhythms 2018 04 21;33(2):126-136. Epub 2018 Jan 21.

Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, Pennsylvania.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/0748730417753003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6692290PMC
April 2018

A Circadian Clock in the Blood-Brain Barrier Regulates Xenobiotic Efflux.

Cell 2018 03 8;173(1):130-139.e10. Epub 2018 Mar 8.

Center for Sleep and Circadian Neurobiology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA; Chronobiology Program at Penn and Howard Hughes Medical Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cell.2018.02.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5866247PMC
March 2018

A Conserved Circadian Function for the Neurofibromatosis 1 Gene.

Cell Rep 2018 03;22(13):3416-3426

Penn Chronobiology, Howard Hughes Medical Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.celrep.2018.03.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5898822PMC
March 2018

Flies come through again, period.

Authors:
Amita Sehgal

J Clin Invest 2018 01 27;128(1):108-109. Epub 2017 Nov 27.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1172/JCI97839DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5749536PMC
January 2018

Physiology Flies with Time.

Authors:
Amita Sehgal

Cell 2017 Nov;171(6):1232-1235

Chronobiology Program, HHMI, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cell.2017.11.028DOI Listing
November 2017

Guidelines for Genome-Scale Analysis of Biological Rhythms.

J Biol Rhythms 2017 Oct 3;32(5):380-393. Epub 2017 Nov 3.

27 Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/0748730417728663DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5692188PMC
October 2017

Molecular Mechanisms of Sleep Homeostasis in Flies and Mammals.

Cold Spring Harb Perspect Biol 2017 Aug 1;9(8). Epub 2017 Aug 1.

Department of Neuroscience, Perelman School of Medicine at University of Pennsylvania, Philadelphia, Pennsylvania 19104-6058.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1101/cshperspect.a027730DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5538413PMC
August 2017

A Peptidergic Circuit Links the Circadian Clock to Locomotor Activity.

Curr Biol 2017 Jul 29;27(13):1915-1927.e5. Epub 2017 Jun 29.

Howard Hughes Medical Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cub.2017.05.089DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5698909PMC
July 2017

The Drosophila circuitry of sleep-wake regulation.

Curr Opin Neurobiol 2017 06 30;44:243-250. Epub 2017 Mar 30.

Howard Hughes Medical Institute, Chronobiology Program, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.conb.2017.03.004DOI Listing
June 2017

Circadian Rhythms and Sleep in .

Genetics 2017 Apr;205(4):1373-1397

Chronobiology Program, Howard Hughes Medical Institute (HHMI), Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104

View Article

Download full-text PDF

Source
http://www.genetics.org/lookup/doi/10.1534/genetics.115.1851
Publisher Site
http://dx.doi.org/10.1534/genetics.115.185157DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5378101PMC
April 2017

Human and rat gut microbiome composition is maintained following sleep restriction.

Proc Natl Acad Sci U S A 2017 02 8;114(8):E1564-E1571. Epub 2017 Feb 8.

Chronobiology Program, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104;

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.1620673114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5338418PMC
February 2017

Changes in Female Drosophila Sleep following Mating Are Mediated by SPSN-SAG Neurons.

J Biol Rhythms 2016 12 22;31(6):551-567. Epub 2016 Sep 22.

Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/0748730416668048DOI Listing
December 2016

Circadian and feeding cues integrate to drive rhythms of physiology in Drosophila insulin-producing cells.

Genes Dev 2016 12 15;30(23):2596-2606. Epub 2016 Dec 15.

Howard Hughes Medical Institute, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

View Article

Download full-text PDF

Source
http://genesdev.cshlp.org/lookup/doi/10.1101/gad.288258.116
Publisher Site
http://dx.doi.org/10.1101/gad.288258.116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5204352PMC
December 2016

Tumors set time.

Science 2016 09;353(6303):987-988

Howard Hughes Medical Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1126/science.aai7631DOI Listing
September 2016

Genetic Dissociation of Daily Sleep and Sleep Following Thermogenetic Sleep Deprivation in Drosophila.

Sleep 2016 May 1;39(5):1083-95. Epub 2016 May 1.

Department of Neuroscience, HHMI, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5665/sleep.5760DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4835307PMC
May 2016

Circadian Rhythms, Sleep, and Disorders of Aging.

Trends Endocrinol Metab 2016 Apr 3;27(4):192-203. Epub 2016 Mar 3.

HHMI, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. Electronic address:

View Article

Download full-text PDF

Source
http://www.cell.com/trends/endocrinology-metabolism/pdf/S104
Web Search
http://dx.doi.org/10.1016/j.tem.2016.02.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4808513PMC
April 2016

Neural clocks and Neuropeptide F/Y regulate circadian gene expression in a peripheral metabolic tissue.

Elife 2016 04 14;5. Epub 2016 Apr 14.

Howard Hughes Medical Institute, University of Pennsylvania, Philadelphia, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7554/eLife.13552DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4862751PMC
April 2016

Caffeine promotes wakefulness via dopamine signaling in Drosophila.

Sci Rep 2016 Feb 12;6:20938. Epub 2016 Feb 12.

Cell and Molecular Biology Program, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/srep20938DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4751479PMC
February 2016

Ribosome profiling reveals an important role for translational control in circadian gene expression.

Genome Res 2015 Dec 3;25(12):1836-47. Epub 2015 Sep 3.

Department of Neuroscience, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania 19104, USA; Howard Hughes Medical Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania 19104, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1101/gr.191296.115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4665005PMC
December 2015

Identification of Redeye, a new sleep-regulating protein whose expression is modulated by sleep amount.

Elife 2014 4;3:e01473. Epub 2014 Feb 4.

Howard Hughes Medical Institute, University of Pennsylvania, Philadelphia, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7554/eLife.01473DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3912633PMC
November 2015

Methods in Enzymology. Circadian rhythms and biological clocks, part B. Preface.

Authors:
Amita Sehgal

Methods Enzymol 2015 ;552:xvii-xviii

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/S0076-6879(15)00162-7DOI Listing
November 2015

Anaplastic Lymphoma Kinase Acts in the Drosophila Mushroom Body to Negatively Regulate Sleep.

PLoS Genet 2015 Nov 4;11(11):e1005611. Epub 2015 Nov 4.

Howard Hughes Medical Institute, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1371/journal.pgen.1005611DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4633181PMC
November 2015

Drosophila Nipped-B Mutants Model Cornelia de Lange Syndrome in Growth and Behavior.

PLoS Genet 2015 Nov 6;11(11):e1005655. Epub 2015 Nov 6.

Edward A Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, Saint Louis, Missouri, United States of America.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1371/journal.pgen.1005655DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4636142PMC
November 2015

Methods in Enzymology. Circadian rhythms and biological clocks, part A. Preface.

Authors:
Amita Sehgal

Methods Enzymol 2015 ;551:xvii-xviii

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/S0076-6879(15)00065-8DOI Listing
October 2015

Context-specific comparison of sleep acquisition systems in Drosophila.

Biol Open 2015 Oct 30;4(11):1558-68. Epub 2015 Oct 30.

Department of Biology, University of Nevada-Reno, Reno, NV 89557, USA Department of Biological Sciences, Florida Atlantic University, 5353 Parkside Drive, Jupiter, FL 33458, USA

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1242/bio.013011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4728345PMC
October 2015

Independent Effects of γ-Aminobutyric Acid Transaminase (GABAT) on Metabolic and Sleep Homeostasis.

J Biol Chem 2015 Aug 29;290(33):20407-16. Epub 2015 Jun 29.

From the Departments of Neuroscience and the Howard Hughes Medical Institute, Chevy Chase, Maryland 20815-6789, and the Department of Cell and Molecular Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6064

View Article

Download full-text PDF

Source
http://www.jbc.org/lookup/doi/10.1074/jbc.M114.602276
Publisher Site
http://dx.doi.org/10.1074/jbc.M114.602276DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4536446PMC
August 2015

KPNB1 mediates PER/CRY nuclear translocation and circadian clock function.

Elife 2015 Aug 29;4. Epub 2015 Aug 29.

Department of Systems Pharmacology and Translational Therapeutics, Institute for Translational Medicine and Therapeutics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, United States.

View Article

Download full-text PDF

Source
https://elifesciences.org/content/4/e08647v1.pdf
Web Search
https://elifesciences.org/content/4/e08647-download.pdf
Web Search
http://elifesciences.org/lookup/doi/10.7554/eLife.08647
Publisher Site
http://dx.doi.org/10.7554/eLife.08647DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4597257PMC
August 2015

Sleep deprivation suppresses aggression in Drosophila.

Elife 2015 Jul 28;4:e07643. Epub 2015 Jul 28.

Department of Neuroscience, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7554/eLife.07643DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4515473PMC
July 2015

Temperature oscillations drive cycles in the activity of MMP-2,9 secreted by a human trabecular meshwork cell line.

Invest Ophthalmol Vis Sci 2015 Feb 5;56(2):1396-405. Epub 2015 Feb 5.

Department of Physiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1167/iovs.14-15834DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4340433PMC
February 2015

Drosophila TIM binds importin α1, and acts as an adapter to transport PER to the nucleus.

PLoS Genet 2015 Feb 12;11(2):e1004974. Epub 2015 Feb 12.

Howard Hughes Medical Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, United States of America.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1371/journal.pgen.1004974DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4335507PMC
February 2015

Oxalic acid and diacylglycerol 36:3 are cross-species markers of sleep debt.

Proc Natl Acad Sci U S A 2015 Feb 9;112(8):2569-74. Epub 2015 Feb 9.

Program in Chronobiology, Howard Hughes Medical Institute, University of Pennsylvania, Philadelphia, PA 19104; and

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.1417432112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4345602PMC
February 2015

Heating and cooling the clock.

Curr Opin Insect Sci 2015 Feb;7:71-75

Department of Neuroscience, University of Pennsylvania School of Medicine; Philadelphia, Pennsylvania, 19104; USA ; Howard Hughes Medical Institute; Chevy Chase, Maryland, 20815; USA ; Department of Cell and Molecular Biology, University of Pennsylvania School of Medicine; Philadelphia, Pennsylvania, 19104; USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cois.2014.12.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4480787PMC
February 2015

An ecdysone-responsive nuclear receptor regulates circadian rhythms in Drosophila.

Nat Commun 2014 Dec 16;5:5697. Epub 2014 Dec 16.

1] Department of Neuroscience, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA [2] Howard Hughes Medical Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

View Article

Download full-text PDF

Source
http://www.nature.com/articles/ncomms6697
Publisher Site
http://dx.doi.org/10.1038/ncomms6697DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4269253PMC
December 2014

Monoamines and sleep in Drosophila.

Behav Neurosci 2014 Jun;128(3):264-72

Howard Hughes Medical Institute, Department of Neuroscience.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1037/a0036209DOI Listing
June 2014

Natural Populations of Drosophila melanogaster Reveal Features of an Uncharacterized Circadian Property: The Lower Temperature Limit of Rhythmicity.

J Biol Rhythms 2014 Jun 10;29(3):167-180. Epub 2014 Jun 10.

Department of Neuroscience, University of Pennsylvania School of Medicine, Philadelphia, PA, USA Howard Hughes Medical Institute, Chevy Chase, MD, USA

View Article

Download full-text PDF

Source
http://journals.sagepub.com/doi/10.1177/0748730414537801
Publisher Site
http://dx.doi.org/10.1177/0748730414537801DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4262728PMC
June 2014

WIDE AWAKE mediates the circadian timing of sleep onset.

Neuron 2014 Apr 13;82(1):151-66. Epub 2014 Mar 13.

Department of Neurology, Johns Hopkins University, Baltimore, MD 21287, USA; Department of Neuroscience, Johns Hopkins University, Baltimore, MD 21287, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neuron.2014.01.040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3982794PMC
April 2014

A critical period of sleep for development of courtship circuitry and behavior in Drosophila.

Science 2014 Apr;344(6181):269-74

Department of Psychiatry, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1126/science.1250553DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4479292PMC
April 2014

Identification of a circadian output circuit for rest:activity rhythms in Drosophila.

Cell 2014 Apr;157(3):689-701

Department of Neuroscience, University of Pennsylvania, Philadelphia, PA 19104, USA; Howard Hughes Medical Institute, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cell.2014.02.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4003459PMC
April 2014

Genetic and anatomical basis of the barrier separating wakefulness and anesthetic-induced unresponsiveness.

PLoS Genet 2013 5;9(9):e1003605. Epub 2013 Sep 5.

Department of Pharmacology, University of California San Diego, La Jolla, California, United States of America.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1371/journal.pgen.1003605DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3764144PMC
March 2014

Cooperative interaction between phosphorylation sites on PERIOD maintains circadian period in Drosophila.

PLoS Genet 2013 26;9(9):e1003749. Epub 2013 Sep 26.

Department of Neuroscience, University of Pennsylvania School of Medicine, Translational Research Center, Philadelphia, Pennsylvania, United States of America.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1371/journal.pgen.1003749DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3784489PMC
March 2014

Day-night cycles and the sleep-promoting factor, Sleepless, affect stem cell activity in the Drosophila testis.

Proc Natl Acad Sci U S A 2014 Feb 10;111(8):3026-31. Epub 2014 Feb 10.

Cancer Biology Program, Fox Chase Cancer Center, Temple University School of Medicine, Philadelphia, PA 19111-2497.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.1316552111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3939882PMC
February 2014

Regulation of insect behavior via the insulin-signaling pathway.

Front Physiol 2013 Dec 3;4:353. Epub 2013 Dec 3.

Cell and Molecular Biology, University of Pennsylvania Philadelphia, PA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fphys.2013.00353DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3847551PMC
December 2013

New perspectives on circadian rhythms and sleep.

Curr Opin Neurobiol 2013 Oct 30;23(5):721-3. Epub 2013 Jul 30.

James Jackson Putnam Professor of Neurology and Neuroscience, Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, United States; Department of Neurology, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02215, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.conb.2013.07.005DOI Listing
October 2013

Adaptation of molecular circadian clockwork to environmental changes: a role for alternative splicing and miRNAs.

Proc Biol Sci 2013 Aug 3;280(1765):20130011. Epub 2013 Jul 3.

Department of Biological Chemistry, The Alexander Silberman Institute of Life Sciences, The Hebrew University of Jerusalem, Edmond J. Safra Campus, Givat-Ram, 91904 Jerusalem, Israel.

View Article

Download full-text PDF

Source
http://rspb.royalsocietypublishing.org/content/royprsb/280/1
Web Search
http://rspb.royalsocietypublishing.org/cgi/doi/10.1098/rspb.
Publisher Site
http://dx.doi.org/10.1098/rspb.2013.0011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3712432PMC
August 2013

Small-molecule screen in adult Drosophila identifies VMAT as a regulator of sleep.

J Neurosci 2013 May;33(19):8534-40

Cell and Molecular Biology Program and Department of Neuroscience, Howard Hughes Medical Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1523/JNEUROSCI.0253-13.2013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3677510PMC
May 2013

Effect of taurine and caffeine on sleep-wake activity in Drosophila melanogaster.

Nat Sci Sleep 2010 24;2:221-31. Epub 2010 Sep 24.

Department of Biology, Coastal Carolina University, Conway, SC, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2147/NSS.S13034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3630960PMC
April 2013

Speed control: cogs and gears that drive the circadian clock.

Trends Neurosci 2012 Sep 28;35(9):574-85. Epub 2012 Jun 28.

Department of Neuroscience, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA.

View Article

Download full-text PDF

Source
http://linkinghub.elsevier.com/retrieve/pii/S016622361200108
Publisher Site
http://dx.doi.org/10.1016/j.tins.2012.05.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3434952PMC
September 2012

Interaction between sleep and metabolism in Drosophila with altered octopamine signaling.

J Biol Chem 2012 Sep 24;287(39):32406-14. Epub 2012 Jul 24.

Department of Neuroscience, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

View Article

Download full-text PDF

Source
http://www.jbc.org/lookup/doi/10.1074/jbc.M112.360875
Publisher Site
http://dx.doi.org/10.1074/jbc.M112.360875DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3463357PMC
September 2012

Old flies have a robust central oscillator but weaker behavioral rhythms that can be improved by genetic and environmental manipulations.

Aging Cell 2012 Jun 24;11(3):428-38. Epub 2012 Feb 24.

Cell and Molecular Biology Program, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/j.1474-9726.2012.00800.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3353743PMC
June 2012

Dopamine acts through Cryptochrome to promote acute arousal in Drosophila.

Genes Dev 2012 Jun 11;26(11):1224-34. Epub 2012 May 11.

Howard Hughes Medical Institute, Department of Neuroscience, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1101/gad.186338.111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3371410PMC
June 2012

Regulation of circadian behavioral output via a MicroRNA-JAK/STAT circuit.

Cell 2012 Feb 2;148(4):765-79. Epub 2012 Feb 2.

Cell and Molecular Biology Program, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cell.2011.12.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3307393PMC
February 2012

The central clock neurons regulate lipid storage in Drosophila.

PLoS One 2011 18;6(5):e19921. Epub 2011 May 18.

Department of Neuroscience, The University of Pennsylvania, Philadelphia, Pennsylvania, United States of America.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0019921PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3097222PMC
November 2011

Drosophila QVR/SSS modulates the activation and C-type inactivation kinetics of Shaker K(+) channels.

J Neurosci 2011 Aug;31(31):11387-95

Department of Neuroscience, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1523/JNEUROSCI.0502-11.2011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3183472PMC
August 2011

Post-translational regulation and nuclear entry of TIMELESS and PERIOD are affected in new timeless mutant.

J Neurosci 2011 Jul;31(27):9982-90

HHMI, Department of Neuroscience, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1523/JNEUROSCI.0993-11.2011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3139226PMC
July 2011

Genetics of sleep and sleep disorders.

Cell 2011 Jul;146(2):194-207

Howard Hughes Medical institute, Department of Neuroscience, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cell.2011.07.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3153991PMC
July 2011

The circadian clock interacts with metabolic physiology to influence reproductive fitness.

Cell Metab 2011 Jun;13(6):639-54

Department of Neuroscience, Howard Hughes Medical Institute, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cmet.2011.05.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3152999PMC
June 2011

AKT and TOR signaling set the pace of the circadian pacemaker.

Curr Biol 2010 Jul 17;20(13):1203-8. Epub 2010 Jun 17.

Department of Neuroscience, Howard Hughes Medical Institute, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cub.2010.05.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3165196PMC
July 2010

Genetic analysis of sleep.

Genes Dev 2010 Jun;24(12):1220-35

Howard Hughes Medical institute, Department of Neuroscience, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1101/gad.1913110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2885658PMC
June 2010

Identification of a neural circuit that underlies the effects of octopamine on sleep:wake behavior.

Neuron 2010 Mar;65(5):670-81

Department of Neuroscience, University of Pennsylvania Medical School, Philadelphia, PA 19104, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neuron.2010.01.032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2862355PMC
March 2010

SLEEPLESS, a Ly-6/neurotoxin family member, regulates the levels, localization and activity of Shaker.

Nat Neurosci 2010 Jan 13;13(1):69-75. Epub 2009 Dec 13.

Division of Sleep Medicine, Department of Neurology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nn.2454DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2842941PMC
January 2010

New routes for memory retrieval and reinforcement.

Cell 2009 Oct;139(2):225-7

Department of Neuroscience, University of Pennsylvania, Philadelphia, PA 19104, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cell.2009.09.031DOI Listing
October 2009

An isoform-specific mutant reveals a role of PDP1 epsilon in the circadian oscillator.

J Neurosci 2009 Sep;29(35):10920-7

Department of Neuroscience, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1523/JNEUROSCI.2133-09.2009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2757269PMC
September 2009

The effects of caffeine on sleep in Drosophila require PKA activity, but not the adenosine receptor.

J Neurosci 2009 Sep;29(35):11029-37

Division of Sleep Medicine, Department of Neurology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1523/JNEUROSCI.1653-09.2009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2757164PMC
September 2009

Energy stores are not altered by long-term partial sleep deprivation in Drosophila melanogaster.

PLoS One 2009 Jul 10;4(7):e6211. Epub 2009 Jul 10.

Howard Hughes Medical Institute, Department of Neuroscience, School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0006211PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2703806PMC
July 2009

Regulation of feeding and metabolism by neuronal and peripheral clocks in Drosophila.

Cell Metab 2008 Oct;8(4):289-300

Howard Hughes Medical Institute, Department of Neuroscience, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cmet.2008.09.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2703740PMC
October 2008

Octopamine regulates sleep in drosophila through protein kinase A-dependent mechanisms.

J Neurosci 2008 Sep;28(38):9377-85

Department of Neuroscience, Howard Hughes Medical Institute, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1523/JNEUROSCI.3072-08a.2008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2742176PMC
September 2008

A Drosophila model for Angelman syndrome.

Proc Natl Acad Sci U S A 2008 Aug 13;105(34):12399-404. Epub 2008 Aug 13.

Section of Molecular Cell and Developmental Biology, Institute for Cell and Molecular Biology, University of Texas, 1 University Station A4800, Austin, TX 78712, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.0805291105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2527923PMC
August 2008

Identification of SLEEPLESS, a sleep-promoting factor.

Science 2008 Jul;321(5887):372-6

Howard Hughes Medical Institute, Department of Neuroscience, University of Pennsylvania, Philadelphia, PA 19104, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1126/science.1155942DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2771549PMC
July 2008

Identification of novel genes involved in light-dependent CRY degradation through a genome-wide RNAi screen.

Genes Dev 2008 Jun;22(11):1522-33

Howard Hughes Medical Institute, Department of Neuroscience, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA.

View Article

Download full-text PDF

Source
http://www.genesdev.org/cgi/doi/10.1101/gad.1652308
Publisher Site
http://dx.doi.org/10.1101/gad.1652308DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2418588PMC
June 2008

Quantitative genetic analysis of sleep in Drosophila melanogaster.

Genetics 2008 Apr;178(4):2341-60

Howard Hughes Medical Institute, Department of Neuroscience, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1534/genetics.107.081232DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2323820PMC
April 2008

A genetic screen for sleep and circadian mutants reveals mechanisms underlying regulation of sleep in Drosophila.

Sleep 2008 Apr;31(4):465-72

Division of Sleep Medicine, Department of Neurology, University of Pennsylvania, Philadelphia, PA 19104, USA.

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2279757PMC
http://dx.doi.org/10.1093/sleep/31.4.465DOI Listing
April 2008

Probing the relative importance of molecular oscillations in the circadian clock.

Genetics 2008 Mar;178(3):1147-55

Howard Hughes Medical Institute, Department of Neuroscience, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1534/genetics.107.088658DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2278066PMC
March 2008

The circadian clock protein BMAL1 is necessary for fertility and proper testosterone production in mice.

J Biol Rhythms 2008 Feb;23(1):26-36

Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/0748730407311254DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2862364PMC
February 2008

Ac-ing the clock.

Authors:
Amita Sehgal

Neuron 2008 Jan;57(1):8-10

Howard Hughes Medical Institute, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neuron.2007.12.018DOI Listing
January 2008

FOXO and insulin signaling regulate sensitivity of the circadian clock to oxidative stress.

Proc Natl Acad Sci U S A 2007 Oct 25;104(40):15899-904. Epub 2007 Sep 25.

Howard Hughes Medical Institute and Department of Neuroscience, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.0701599104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2000406PMC
October 2007

Post-translational regulation of the Drosophila circadian clock requires protein phosphatase 1 (PP1).

Genes Dev 2007 Jun;21(12):1506-18

Howard Hughes Medical Institute, Department of Neuroscience, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA.

View Article

Download full-text PDF

Source
http://www.genesdev.org/cgi/doi/10.1101/gad.1541607
Publisher Site
http://dx.doi.org/10.1101/gad.1541607DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1891428PMC
June 2007

Interaction between sleep and the immune response in Drosophila: a role for the NFkappaB relish.

Sleep 2007 Apr;30(4):389-400

Center for Advanced Biotechnology and Medicine and Department of Pharmacology, University of Medicine and Dentistry of New Jersey, Piscataway 08854-5603, USA.

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2884379PMC
http://dx.doi.org/10.1093/sleep/30.4.389DOI Listing
April 2007

A Drosophila model for age-associated changes in sleep:wake cycles.

Proc Natl Acad Sci U S A 2006 Sep 28;103(37):13843-7. Epub 2006 Aug 28.

Howard Hughes Medical Institute, Department of Neuroscience, School of Medicine, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

View Article

Download full-text PDF

Source
http://www.pnas.org/cgi/doi/10.1073/pnas.0605903103
Publisher Site
http://dx.doi.org/10.1073/pnas.0605903103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1564207PMC
September 2006