Dr. Amita Joshi, PhD -  Merck & Co - Associate Director

Dr. Amita Joshi

PhD

Merck & Co

Associate Director

Lansdale, PA | United States

ORCID logohttps://orcid.org/0000-0002-2646-9478

Dr. Amita Joshi, PhD -  Merck & Co - Associate Director

Dr. Amita Joshi

PhD

Introduction

Primary Affiliation: Merck & Co - Lansdale, PA , United States

Publications

67Publications

1527Reads

1Profile Views

856PubMed Central Citations

Multilocular peritoneal inclusion cyst, rare occurrence in men: A case report.

Indian J Pathol Microbiol 2018 Jan-Mar;61(1):164-166

Department of Pathology, Seth GS Medical College, Mumbai, Maharashtra, India.

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http://dx.doi.org/10.4103/IJPM.IJPM_480_16DOI Listing
January 2019
4 Reads
0.642 Impact Factor

Primary Biliary Cholangitis- Autoimmune Hepatitis Overlap Syndrome.

Indian J Pediatr 2018 09 9;85(9):803-805. Epub 2018 Feb 9.

Department of Gastroenterology, Seth G S Medical College and KEM Hospital, Multistorey Building, 11th Floor, Parel, Mumbai, 400012, India.

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http://dx.doi.org/10.1007/s12098-018-2628-xDOI Listing
September 2018
23 Reads
0.920 Impact Factor

Exposure-response analyses of trastuzumab emtansine in patients with HER2-positive advanced breast cancer previously treated with trastuzumab and a taxane.

Cancer Chemother Pharmacol 2017 Dec 11;80(6):1079-1090. Epub 2017 Oct 11.

Department of Clinical Pharmacology, Genentech, Inc., 1 DNA Way, South San Francisco, CA, 94080, USA.

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http://dx.doi.org/10.1007/s00280-017-3440-4DOI Listing
December 2017
77 Reads
1 Citation
2.770 Impact Factor

Development and Validation of a Stability-Indicating HPLC Method for Imidapril and Its Degradation Products Using a Design of Experiment (DoE) Approach.

J AOAC Int 2017 Nov 14;100(6):1727-1738. Epub 2017 Aug 14.

B.V. Patel Pharmaceutical Education and Research Development Centre, Department of Medicinal Chemistry, Ahmedabad, Gujarat, India.

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http://dx.doi.org/10.5740/jaoacint.16-0329DOI Listing
November 2017
18 Reads
1.385 Impact Factor

Secondary sclerosing cholangitis in localized hepatobiliary tuberculosis simulating cholangiocarcinoma: a rare case report.

BMC Gastroenterol 2017 Nov 28;17(1):126. Epub 2017 Nov 28.

Department of Pathology, TNMC & Nair Ch hospital, Mumbai, India.

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http://dx.doi.org/10.1186/s12876-017-0690-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5704558PMC
November 2017
12 Reads
2.370 Impact Factor

Antibody persistence and evidence of immune memory at 5years following administration of the 9-valent HPV vaccine.

Vaccine 2017 09 5;35(37):5050-5057. Epub 2017 Aug 5.

Merck & Co., Inc., Kenilworth, NJ, USA. Electronic address:

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http://dx.doi.org/10.1016/j.vaccine.2017.07.017DOI Listing
September 2017
13 Reads
3 Citations
3.624 Impact Factor

Melt-in-Mouth Multi-particulate System for the Treatment of ADHD: A Convenient Platform for Pediatric Use.

AAPS PharmSciTech 2016 Aug 21;17(4):878-90. Epub 2015 Sep 21.

Department of Pharmaceutics, B. V. Patel Pharmaceutical Education and Research Development (PERD) Centre, Ahmedabad, 380054, India.

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http://dx.doi.org/10.1208/s12249-015-0412-zDOI Listing
August 2016
1 Read
1 Citation
1.780 Impact Factor

Self-microemulsifying drug delivery system (SMEDDS)--challenges and road ahead.

Drug Deliv 2015 27;22(6):675-90. Epub 2014 Mar 27.

a Department of Pharmaceutics , NIPER Ahmedabad , C/o B.V. Patel PERD Centre , Ahmedabad , Gujarat , India.

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http://dx.doi.org/10.3109/10717544.2014.896058DOI Listing
June 2016
11 Reads
2 Citations
2.202 Impact Factor

A survey of new oncology drug approvals in the USA from 2010 to 2015: a focus on optimal dose and related postmarketing activities.

Cancer Chemother Pharmacol 2016 Mar 25;77(3):459-76. Epub 2016 Jan 25.

Department of Clinical Pharmacology, Genentech, Inc., 1 DNA Way, MS 463A, South San Francisco, CA, 94080, USA.

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http://dx.doi.org/10.1007/s00280-015-2931-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4767861PMC
March 2016
18 Reads
7 Citations
2.770 Impact Factor

Impact of Ternary Solvent System in Stability-Indicating Assay Method of Bambuterol: Design of Experiments Approach.

J Chromatogr Sci 2016 Feb 10;54(2):221-9. Epub 2015 Sep 10.

Department of Medicinal Chemistry, B. V. Patel PERD Centre, Ahmedabad, Gujarat 380054, India

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http://dx.doi.org/10.1093/chromsci/bmv137DOI Listing
February 2016
4 Reads
1.363 Impact Factor

Solid lipid nanoparticles (SLN) of Efavirenz as lymph targeting drug delivery system: Elucidation of mechanism of uptake using chylomicron flow blocking approach.

Int J Pharm 2015 Nov 11;495(1):439-446. Epub 2015 Sep 11.

B.V. Patel PERD Centre, Thaltej, S.G. Highway, Ahmedabad, India. Electronic address:

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http://dx.doi.org/10.1016/j.ijpharm.2015.09.014DOI Listing
November 2015
40 Reads
7 Citations
3.650 Impact Factor

Isolation of genes conferring salt tolerance from Piriformospora indica by random overexpression in Escherichia coli.

World J Microbiol Biotechnol 2015 Aug 16;31(8):1195-209. Epub 2015 May 16.

Plant Molecular Biology Group, International Centre for Genetic Engineering and Biotechnology, Aruna Asaf Ali Marg, New Delhi, 110067, India.

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http://link.springer.com/content/pdf/10.1007%2Fs11274-015-18
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http://link.springer.com/10.1007/s11274-015-1867-5
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http://dx.doi.org/10.1007/s11274-015-1867-5DOI Listing
August 2015
92 Reads
3 Citations
1.780 Impact Factor

Chronic HBV-infected subjects older than 35 years with persistently normal ALT and ultrasound, despite high viral load do not have significant fibrosis.

Indian J Gastroenterol 2015 Jul;34(4):341-2

Department of Gastroenterology, Seth G S Medical College and K E M Hospital, Acharya Dhonde Marg, Parel, Mumbai, 400 012, India.

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http://dx.doi.org/10.1007/s12664-015-0557-4DOI Listing
July 2015
2 Reads
1 Citation

Fulminant amoebic colitis: a clinicopathological study of 30 cases.

Postgrad Med J 2015 Apr 6;91(1074):200-5. Epub 2015 Mar 6.

Department of Pathology, Seth GS Medical College and KEM Hospital, Mumbai, Maharashtra, India.

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http://dx.doi.org/10.1136/postgradmedj-2014-132597DOI Listing
April 2015
3 Reads
1 Citation
1.550 Impact Factor

Challenges and considerations for development of therapeutic proteins in pediatric patients.

J Clin Pharmacol 2015 Mar;55 Suppl 3:S103-15

Former employee of Clinical Pharmacology, Genentech, South San Francisco, USA; Oncology Clinical Pharmacology, Novartis, East Hanover, USA.

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http://dx.doi.org/10.1002/jcph.382DOI Listing
March 2015
3 Reads
3 Citations

Hepatosplenic T cell lymphoma.

Indian J Hematol Blood Transfus 2014 Sep 10;30(Suppl 1):21-3. Epub 2013 Jan 10.

Department of Pathology, Seth GSMC & KEM Hospital, Parel, Mumbai, 22 Maharashtra India.

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http://dx.doi.org/10.1007/s12288-012-0220-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4192185PMC
September 2014
4 Reads
0.234 Impact Factor

Lipid based nanoemulsifying resveratrol for improved physicochemical characteristics, in vitro cytotoxicity and in vivo antiangiogenic efficacy.

Colloids Surf B Biointerfaces 2014 Aug 22;120:110-7. Epub 2014 May 22.

Dept. of Pharmaceutics, B. V. Patel PERD Centre, Ahmedabad, India.

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http://dx.doi.org/10.1016/j.colsurfb.2014.05.016DOI Listing
August 2014
2 Reads
3 Citations
4.152 Impact Factor

Stimulation of ovarian stem cells by follicle stimulating hormone and basic fibroblast growth factor during cortical tissue culture.

J Ovarian Res 2013 Apr 1;6(1):20. Epub 2013 Apr 1.

Stem Cell Biology Department, National Institute for Research in Reproductive Health (NIRRH), JM Street, Parel, Mumbai, 400 012, India.

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http://dx.doi.org/10.1186/1757-2215-6-20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3635909PMC
April 2013
33 Reads
21 Citations
2.430 Impact Factor

Pharmacokinetics of ranibizumab in patients with neovascular age-related macular degeneration: a population approach.

Invest Ophthalmol Vis Sci 2013 Mar 5;54(3):1616-24. Epub 2013 Mar 5.

Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA.

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http://dx.doi.org/10.1167/iovs.12-10260DOI Listing
March 2013
17 Reads
25 Citations
3.404 Impact Factor

Population pharmacokinetics of rituximab in patients with chronic lymphocytic leukemia.

J Clin Pharmacol 2012 Dec 10;52(12):1918-26. Epub 2012 Jan 10.

Clinical Pharmacology, MS 463a, Genentech Inc, 1 DNA Way, South San Francisco, CA 94080, USA.

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http://dx.doi.org/10.1177/0091270011430506DOI Listing
December 2012
3 Reads
15 Citations

Anti-neuropilin-1 (MNRP1685A): unexpected pharmacokinetic differences across species, from preclinical models to humans.

Pharm Res 2012 Sep 16;29(9):2512-21. Epub 2012 Jun 16.

Department of Pharmacokinetic and Pharmacodynamic Sciences, Genentech, Inc., 1 DNA Way, South San Francisco, California, USA.

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http://dx.doi.org/10.1007/s11095-012-0781-xDOI Listing
September 2012
85 Reads
4 Citations
3.420 Impact Factor

Drug interaction potential of trastuzumab emtansine (T-DM1) combined with pertuzumab in patients with HER2-positive metastatic breast cancer.

Curr Drug Metab 2012 Sep;13(7):911-22

Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.

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September 2012
21 Reads
8 Citations
2.980 Impact Factor

Population pharmacokinetic and pharmacodynamic modeling of MNRP1685A in cynomolgus monkeys using two-target quasi-steady-state (QSS) model.

J Pharmacokinet Pharmacodyn 2012 Apr 1;39(2):217-26. Epub 2012 Mar 1.

Department of Pharmacokinetics and Pharmacodynamics, Genentech Research and Early Development, Genentech, Inc, 1 DNA Way, South San Francisco, CA 94080, USA.

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http://dx.doi.org/10.1007/s10928-012-9244-6DOI Listing
April 2012
15 Reads
2 Citations
1.460 Impact Factor

Immunization with Staphylococcus aureus iron regulated surface determinant B (IsdB) confers protection via Th17/IL17 pathway in a murine sepsis model.

Hum Vaccin Immunother 2012 Mar 13;8(3):336-46. Epub 2012 Feb 13.

Merck Research Labs, Merck and Co. Inc., West Point, PA, USA.

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http://dx.doi.org/10.4161/hv.18946DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3426080PMC
March 2012
101 Reads
42 Citations
2.131 Impact Factor

N-Heteroaryl glycinamides and glycinamines as potent NPY5 antagonists.

Bioorg Med Chem Lett 2011 Sep 25;21(18):5573-6. Epub 2011 Jun 25.

Department of Chemical & Pharmacokinetic Sciences, 215 College Road, Paramus, NJ 07652, USA.

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http://dx.doi.org/10.1016/j.bmcl.2011.06.078DOI Listing
September 2011
14 Reads
2.420 Impact Factor

Comparison of human memory CD8 T cell responses to adenoviral early and late proteins in peripheral blood and lymphoid tissue.

PLoS One 2011 27;6(5):e20068. Epub 2011 May 27.

Department of Microbiology and Immunology, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0020068PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3103520PMC
September 2011
1 Read
3.234 Impact Factor

AAPS workshop report: strategies to address therapeutic protein-drug interactions during clinical development.

AAPS J 2011 Sep 1;13(3):405-16. Epub 2011 Jun 1.

Clinical Pharmacology, Department of Pharmacokinetics and Pharmacodynamics, gRED, Genentech, South San Francisco, California, USA.

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http://dx.doi.org/10.1208/s12248-011-9285-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3144367PMC
September 2011
13 Reads
7 Citations
3.800 Impact Factor

Risk factors for Barrett's esophagus in Indian patients with gastroesophageal reflux disease.

J Gastroenterol Hepatol 2011 Jul;26(7):1151-6

Department of Gastroenterology, Seth GS Medical College and King Edward Memorial Hospital, Mumbai, India.

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http://dx.doi.org/10.1111/j.1440-1746.2011.06714.xDOI Listing
July 2011
4 Reads
4 Citations
3.504 Impact Factor

Gastroretentive delivery of rifampicin: in vitro mucoadhesion and in vivo gamma scintigraphy.

Int J Pharm 2011 Jun 31;411(1-2):106-12. Epub 2011 Mar 31.

Department of Pharmaceutics, BV Patel PERD Centre, Sarkhej-Gandhinagar Highway, Thaltej, Ahmedabad 380054, Gujarat, India.

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http://dx.doi.org/10.1016/j.ijpharm.2011.03.048DOI Listing
June 2011
3 Reads
3.650 Impact Factor

Antibody delivery of drugs and radionuclides: factors influencing clinical pharmacology.

Ther Deliv 2011 Jun;2(6):769-91

Early Development Pharmacokinetic & Pharmacodynamic Sciences, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA.

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June 2011
31 Reads
8 Citations

A transcriptional signature and common gene networks link cancer with lipid metabolism and diverse human diseases.

Cancer Cell 2010 Apr;17(4):348-61

Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.ccr.2010.01.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2854678PMC
April 2010
44 Reads
101 Citations
23.523 Impact Factor

Multivariate optimization of formulation and process variables influencing physico-mechanical characteristics of site-specific release isoniazid pellets.

Int J Pharm 2010 Mar 24;388(1-2):64-72. Epub 2009 Dec 24.

B.V. Patel PERD Centre, Department of Pharmaceutics, Sarkhej-Gandhinagar Highway, Thaltej, Ahmedabad 380054, Gujarat, India.

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http://dx.doi.org/10.1016/j.ijpharm.2009.12.034DOI Listing
March 2010
3 Reads
1 Citation
3.650 Impact Factor

Pea lectin receptor-like kinase promotes high salinity stress tolerance in bacteria and expresses in response to stress in planta.

Glycoconj J 2010 Jan 7;27(1):133-50. Epub 2009 Nov 7.

Plant Molecular Biology Group, International Centre for Genetic Engineering and Biotechnology, Aruna Asaf Ali Marg, New Delhi, 110067, India.

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http://dx.doi.org/10.1007/s10719-009-9265-6DOI Listing
January 2010
9 Reads
6 Citations
2.520 Impact Factor

Peutz-Jegher's syndrome presenting as jejunoileal intussusception in an adult male: a case report.

Cases J 2009 Aug 11;2:8865. Epub 2009 Aug 11.

Seth G S Medical College and KEM hospital, Parel, Mumbai 400012, India.

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http://dx.doi.org/10.4076/1757-1626-2-8865DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2769477PMC
August 2009
2 Reads
3 Citations

Isolation of high salinity stress tolerant genes from Pisum sativum by random overexpression in Escherichia coli and their functional validation.

Plant Signal Behav 2009 May 10;4(5):400-12. Epub 2009 May 10.

Plant Molecular Biology Group, International Centre for Genetic Engineering and Biotechnology, Aruna Asaf Ali Marg, New Delhi, India.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2676750PMC
http://dx.doi.org/10.4161/psb.4.5.8387DOI Listing
May 2009
58 Reads
4 Citations

Adenovirus DNA polymerase is recognized by human CD8+ T cells.

J Gen Virol 2009 Jan;90(Pt 1):84-94

Department of Microbiology, Thomas Jefferson University, Philadelphia, PA 19107, USA.

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http://dx.doi.org/10.1099/vir.0.002493-0DOI Listing
January 2009
4 Reads
7 Citations
3.183 Impact Factor

Dissolution test for site-specific release isoniazid pellets in USP apparatus 3 (reciprocating cylinder): optimization using response surface methodology.

Eur J Pharm Biopharm 2008 Jun 14;69(2):769-75. Epub 2007 Dec 14.

B V Patel PERD Centre, Department of Pharmaceutics, Ahmedabad, India.

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http://dx.doi.org/10.1016/j.ejpb.2007.11.020DOI Listing
June 2008
1 Read
4 Citations
3.383 Impact Factor

Use of quantitative pharmacology in the development of HAE1, a high-affinity anti-IgE monoclonal antibody.

AAPS J 2008 Jun 7;10(2):425-30. Epub 2008 Aug 7.

Development Sciences, Genentech Inc., 1 DNA Way, South San Francisco, California, 94080-4990, USA.

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http://dx.doi.org/10.1208/s12248-008-9045-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2751395PMC
June 2008
12 Reads
15 Citations
3.800 Impact Factor

Ileal polyposis as manifestation of neurofibromatosis syndrome.

Indian J Gastroenterol 2006 May-Jun;25(3):159-60

Department of Pathology, Seth G S Medical College and K E M Hospital, Mumbai - 400 012, India.

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December 2006
6 Reads
1 Citation

The application of mechanism-based PK/PD modeling in pharmacodynamic-based dose selection of muM17, a surrogate monoclonal antibody for efalizumab.

J Pharm Sci 2006 Jun;95(6):1258-68

Department of Pharmacokinetic and Pharmacodynamic Sciences, Genentech, Inc., 1 DNA Way, MS 70, South San Francisco, CA 94080, USA.

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http://dx.doi.org/10.1002/jps.20475DOI Listing
June 2006
9 Reads
6 Citations
2.590 Impact Factor

An overview of the pharmacokinetics and pharmacodynamics of efalizumab: a monoclonal antibody approved for use in psoriasis.

J Clin Pharmacol 2006 Jan;46(1):10-20

Department of Pharmacokinetic and Pharmacodynamic Sciences, MS 70, Genentech, Inc, 1 DNA Way, South San Francisco, CA 94080, USA.

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http://dx.doi.org/10.1177/0091270005283282DOI Listing
January 2006
17 Reads
16 Citations

Eaf3 chromodomain interaction with methylated H3-K36 links histone deacetylation to Pol II elongation.

Mol Cell 2005 Dec;20(6):971-8

Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1016/j.molcel.2005.11.021DOI Listing
December 2005
13 Reads
228 Citations
14.020 Impact Factor

Pharmacokinetic-pharmacodynamic-efficacy analysis of efalizumab in patients with moderate to severe psoriasis.

Pharm Res 2005 Jul 22;22(7):1088-100. Epub 2005 Jul 22.

Department of Pharmacokinetic and Pharmacodynamic Sciences, Genentech Inc., 1 DNA Way, South San Francisco, California 94080-4990, USA.

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http://link.springer.com/10.1007/s11095-005-5642-4
Publisher Site
http://dx.doi.org/10.1007/s11095-005-5642-4DOI Listing
July 2005
16 Reads
24 Citations
3.420 Impact Factor

Population pharmacokinetics of efalizumab (humanized monoclonal anti-CD11a antibody) following long-term subcutaneous weekly dosing in psoriasis subjects.

J Clin Pharmacol 2005 Apr;45(4):468-76

Late Stage BioTherapeutics, Department of Pharmacokinetic and Pharmacodynamic Sciences, MS 70, Genentech, Inc, 1 DNA Way, South San Francisco, CA 94080, USA.

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http://dx.doi.org/10.1177/0091270004272731DOI Listing
April 2005
13 Reads
6 Citations

Evaluation of a surrogate antibody for preclinical safety testing of an anti-CD11a monoclonal antibody.

Regul Toxicol Pharmacol 2004 Dec;40(3):219-26

Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.

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http://dx.doi.org/10.1016/j.yrtph.2004.06.007DOI Listing
December 2004
25 Reads
10 Citations
2.031 Impact Factor

Gastric cancer presenting with acute disseminated intravascular coagulation.

Indian J Gastroenterol 2002 Jul-Aug;21(4):164-5

Department of Surgery, Seth G S Medical College and K E M Hospital, Mumbai.

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November 2002
5 Reads
1 Citation

Alagille syndrome.

Indian J Pediatr 2002 Sep;69(9):825-7

Department of Pediatrics, Seth G. S. Medical College and KEM Hospital, Mumbai, Maharashtra, India.

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http://dx.doi.org/10.1007/bf02723701DOI Listing
September 2002
4 Reads
1 Citation
0.920 Impact Factor

ATP hydrolysis induces expansion of MutS contacts on heteroduplex: a case for MutS treadmilling?

Biochemistry 2002 Mar;41(11):3654-66

Department of Biological Sciences, Tata Institute of Fundamental Research, Homi Bhabha Road, Bombay 400 005, India.

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http://dx.doi.org/10.1021/bi015743rDOI Listing
March 2002
1 Read
4 Citations
3.020 Impact Factor