Amit V Khera

Amit V Khera

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Amit V Khera

Publications by authors named "Amit V Khera"

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Leveraging Human Genetics to Estimate Clinical Risk Reductions Achievable by Inhibiting Factor XI.

Stroke 2019 Nov 27;50(11):3004-3012. Epub 2019 Sep 27.

From the Bayer Pharmaceuticals, Open Innovation & Digital Technologies, Wuppertal, Germany (B.G., J.M., K.Z., D.F.F.).

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http://dx.doi.org/10.1161/STROKEAHA.119.026545DOI Listing
November 2019

Genetic Association of Finger Photoplethysmography-Derived Arterial Stiffness Index With Blood Pressure and Coronary Artery Disease.

Arterioscler Thromb Vasc Biol 2019 Jun;39(6):1253-1261

From the Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA (S.M.Z., K.A., C.E., A.V.K., D.K., P.N.).

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https://www.ahajournals.org/doi/10.1161/ATVBAHA.119.312626
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http://dx.doi.org/10.1161/ATVBAHA.119.312626DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6531323PMC
June 2019

Polygenic Prediction of Weight and Obesity Trajectories from Birth to Adulthood.

Cell 2019 Apr;177(3):587-596.e9

Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA 02114, USA; Division of Cardiology, Massachusetts General Hospital, Boston, MA 02114, USA; Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00928674193029
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http://dx.doi.org/10.1016/j.cell.2019.03.028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6661115PMC
April 2019

Genetic inactivation of ANGPTL4 improves glucose homeostasis and is associated with reduced risk of diabetes.

Nat Commun 2018 06 13;9(1):2252. Epub 2018 Jun 13.

Regeneron Pharmaceuticals, Tarrytown, 10591, NY, USA.

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http://dx.doi.org/10.1038/s41467-018-04611-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5997992PMC
June 2018

Exome-wide association study of plasma lipids in >300,000 individuals.

Authors:
Dajiang J Liu Gina M Peloso Haojie Yu Adam S Butterworth Xiao Wang Anubha Mahajan Danish Saleheen Connor Emdin Dewan Alam Alexessander Couto Alves Philippe Amouyel Emanuele Di Angelantonio Dominique Arveiler Themistocles L Assimes Paul L Auer Usman Baber Christie M Ballantyne Lia E Bang Marianne Benn Joshua C Bis Michael Boehnke Eric Boerwinkle Jette Bork-Jensen Erwin P Bottinger Ivan Brandslund Morris Brown Fabio Busonero Mark J Caulfield John C Chambers Daniel I Chasman Y Eugene Chen Yii-Der Ida Chen Rajiv Chowdhury Cramer Christensen Audrey Y Chu John M Connell Francesco Cucca L Adrienne Cupples Scott M Damrauer Gail Davies Ian J Deary George Dedoussis Joshua C Denny Anna Dominiczak Marie-Pierre Dubé Tapani Ebeling Gudny Eiriksdottir Tõnu Esko Aliki-Eleni Farmaki Mary F Feitosa Marco Ferrario Jean Ferrieres Ian Ford Myriam Fornage Paul W Franks Timothy M Frayling Ruth Frikke-Schmidt Lars G Fritsche Philippe Frossard Valentin Fuster Santhi K Ganesh Wei Gao Melissa E Garcia Christian Gieger Franco Giulianini Mark O Goodarzi Harald Grallert Niels Grarup Leif Groop Megan L Grove Vilmundur Gudnason Torben Hansen Tamara B Harris Caroline Hayward Joel N Hirschhorn Oddgeir L Holmen Jennifer Huffman Yong Huo Kristian Hveem Sehrish Jabeen Anne U Jackson Johanna Jakobsdottir Marjo-Riitta Jarvelin Gorm B Jensen Marit E Jørgensen J Wouter Jukema Johanne M Justesen Pia R Kamstrup Stavroula Kanoni Fredrik Karpe Frank Kee Amit V Khera Derek Klarin Heikki A Koistinen Jaspal S Kooner Charles Kooperberg Kari Kuulasmaa Johanna Kuusisto Markku Laakso Timo Lakka Claudia Langenberg Anne Langsted Lenore J Launer Torsten Lauritzen David C M Liewald Li An Lin Allan Linneberg Ruth J F Loos Yingchang Lu Xiangfeng Lu Reedik Mägi Anders Malarstig Ani Manichaikul Alisa K Manning Pekka Mäntyselkä Eirini Marouli Nicholas G D Masca Andrea Maschio James B Meigs Olle Melander Andres Metspalu Andrew P Morris Alanna C Morrison Antonella Mulas Martina Müller-Nurasyid Patricia B Munroe Matt J Neville Jonas B Nielsen Sune F Nielsen Børge G Nordestgaard Jose M Ordovas Roxana Mehran Christoper J O'Donnell Marju Orho-Melander Cliona M Molony Pieter Muntendam Sandosh Padmanabhan Colin N A Palmer Dorota Pasko Aniruddh P Patel Oluf Pedersen Markus Perola Annette Peters Charlotta Pisinger Giorgio Pistis Ozren Polasek Neil Poulter Bruce M Psaty Daniel J Rader Asif Rasheed Rainer Rauramaa Dermot F Reilly Alex P Reiner Frida Renström Stephen S Rich Paul M Ridker John D Rioux Neil R Robertson Dan M Roden Jerome I Rotter Igor Rudan Veikko Salomaa Nilesh J Samani Serena Sanna Naveed Sattar Ellen M Schmidt Robert A Scott Peter Sever Raquel S Sevilla Christian M Shaffer Xueling Sim Suthesh Sivapalaratnam Kerrin S Small Albert V Smith Blair H Smith Sangeetha Somayajula Lorraine Southam Timothy D Spector Elizabeth K Speliotes John M Starr Kathleen E Stirrups Nathan Stitziel Konstantin Strauch Heather M Stringham Praveen Surendran Hayato Tada Alan R Tall Hua Tang Jean-Claude Tardif Kent D Taylor Stella Trompet Philip S Tsao Jaakko Tuomilehto Anne Tybjaerg-Hansen Natalie R van Zuydam Anette Varbo Tibor V Varga Jarmo Virtamo Melanie Waldenberger Nan Wang Nick J Wareham Helen R Warren Peter E Weeke Joshua Weinstock Jennifer Wessel James G Wilson Peter W F Wilson Ming Xu Hanieh Yaghootkar Robin Young Eleftheria Zeggini He Zhang Neil S Zheng Weihua Zhang Yan Zhang Wei Zhou Yanhua Zhou Magdalena Zoledziewska Joanna M M Howson John Danesh Mark I McCarthy Chad A Cowan Goncalo Abecasis Panos Deloukas Kiran Musunuru Cristen J Willer Sekar Kathiresan

Nat Genet 2017 Dec 30;49(12):1758-1766. Epub 2017 Oct 30.

Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA.

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http://dx.doi.org/10.1038/ng.3977DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5709146PMC
December 2017

Mendelian Randomization.

JAMA 2017 Nov;318(19):1925-1926

Center for Genomic Medicine, Massachusetts General Hospital, Harvard Medical School, Boston.

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http://dx.doi.org/10.1001/jama.2017.17219DOI Listing
November 2017

Genetic Variation at the Sulfonylurea Receptor, Type 2 Diabetes, and Coronary Heart Disease.

Diabetes 2017 08 14;66(8):2310-2315. Epub 2017 Apr 14.

Center for Genomic Medicine, Cardiology Division, Massachusetts General Hospital, Harvard Medical School, Boston, MA

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http://dx.doi.org/10.2337/db17-0149DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5521864PMC
August 2017

A Genetic Variant Associated with Five Vascular Diseases Is a Distal Regulator of Endothelin-1 Gene Expression.

Cell 2017 Jul;170(3):522-533.e15

Broad Institute of MIT and Harvard University, Cambridge, MA, USA; Cardiology Division, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA USA; Center for Genomic Medicine, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2017.06.049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5785707PMC
July 2017

Genetics of coronary artery disease: discovery, biology and clinical translation.

Nat Rev Genet 2017 06 13;18(6):331-344. Epub 2017 Mar 13.

Division of Cardiology, Department of Medicine and Center for Genomic Medicine, Massachusetts General Hospital; Cardiovascular Disease Initiative, Broad Institute of Harvard and Massachusetts Institute of Technology, 185 Cambridge Street, CPZN 5.252, Boston, Massachusetts 02114, USA.

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http://dx.doi.org/10.1038/nrg.2016.160DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5935119PMC
June 2017

Cholesterol Efflux Capacity, High-Density Lipoprotein Particle Number, and Incident Cardiovascular Events: An Analysis From the JUPITER Trial (Justification for the Use of Statins in Prevention: An Intervention Trial Evaluating Rosuvastatin).

Circulation 2017 Jun 27;135(25):2494-2504. Epub 2017 Apr 27.

From Cardiology Division and Center for Genomic Medicine, Massachusetts General Hospital, Boston (A.V.K.); Harvard Medical School, Boston, MA (A.V.K., O.V.D., P.MR., S.M.); Center for Lipid Metabolomics and Division of Preventive Medicine (A.V.K., O.V.D., R.J.G., P.MR., S.M.), Division of Cardiovascular Medicine (P.MR., S.M.), Brigham and Women's Hospital, Boston, MA; Vascular Strategies, Plymouth Meeting, PA (S.J.A., H.L.C.); and Department of Genetics, University of Pennsylvania, Philadelphia (D.J.R.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.116.025678DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5490983PMC
June 2017

Genetic Predisposition to Abdominal Obesity and Cardiometabolic Risk-Reply.

JAMA 2017 06;317(22):2334-2335

Massachusetts General Hospital, Boston.

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http://dx.doi.org/10.1001/jama.2017.5044DOI Listing
June 2017

ANGPTL3 Deficiency and Protection Against Coronary Artery Disease.

J Am Coll Cardiol 2017 Apr 3;69(16):2054-2063. Epub 2017 Apr 3.

Center for Human Genetic Research, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts; Cardiovascular Research Center and Cardiology Division, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts. Electronic address:

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http://dx.doi.org/10.1016/j.jacc.2017.02.030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5404817PMC
April 2017

Evaluation of the Pooled Cohort Equations for Prediction of Cardiovascular Risk in a Contemporary Prospective Cohort.

Am J Cardiol 2017 Mar 18;119(6):881-885. Epub 2016 Dec 18.

Center for Human Genetic Research and Cardiology Division, Massachusetts General Hospital, Boston, Massachusetts; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts. Electronic address:

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http://dx.doi.org/10.1016/j.amjcard.2016.11.042DOI Listing
March 2017

Is Coronary Atherosclerosis One Disease or Many? Setting Realistic Expectations for Precision Medicine.

Circulation 2017 03;135(11):1005-1007

From Center for Genomic Medicine and Cardiology Division, Massachusetts General Hospital, Boston (A.V.K, S.K.); and the Program in Medical and Population Genetics, Broad Institute, Cambridge, MA (A.V.K, S.K.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.116.026479DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5395046PMC
March 2017

Genetic Risk, Lifestyle, and Coronary Artery Disease.

N Engl J Med 2017 03;376(12):1194-5

Massachusetts General Hospital, Boston, MA

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http://dx.doi.org/10.1056/NEJMc1700362DOI Listing
March 2017

Child-Parent Familial Hypercholesterolemia Screening in Primary Care.

N Engl J Med 2017 02;376(5):498-9

Massachusetts General Hospital, Boston, MA

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http://www.nejm.org/doi/10.1056/NEJMc1615365
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http://dx.doi.org/10.1056/NEJMc1615365DOI Listing
February 2017

Genetic Association of Waist-to-Hip Ratio With Cardiometabolic Traits, Type 2 Diabetes, and Coronary Heart Disease.

JAMA 2017 02;317(6):626-634

Center for Genomic Medicine and Cardiology Division, Massachusetts General Hospital, Harvard Medical School, Boston2Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts.

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http://dx.doi.org/10.1001/jama.2016.21042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5571980PMC
February 2017

Demystifying HDL Cholesterol-A "Human Knockout" to the Rescue?

Clin Chem 2017 01 6;63(1):33-36. Epub 2016 Oct 6.

Center for Cardiovascular Disease Prevention and Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.

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http://dx.doi.org/10.1373/clinchem.2016.258244DOI Listing
January 2017

Genetic Risk, Adherence to a Healthy Lifestyle, and Coronary Disease.

N Engl J Med 2016 12 13;375(24):2349-2358. Epub 2016 Nov 13.

From the Center for Human Genetic Research and Cardiology Division, Massachusetts General Hospital (A.V.K., P.N., S.K.), and the Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital (N.R.C., D.I.C., P.M.R.), Boston, and the Program in Medical and Population Genetics, Broad Institute, Cambridge (A.V.K., C.A.E., A.G.B., S.K.) - all in Massachusetts; the Department of Clinical Sciences, Lund University, Malmö, Sweden (I.D., O.M., M.O.-M.); the Cardiovascular Institute, Mount Sinai Medical Center, Icahn School of Medicine at Mount Sinai, New York (U.B., R.M., V.F.); Department of Genetics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia (D.J.R.); and the University of Texas Health Science Center School of Public Health, Houston (E.B.).

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http://dx.doi.org/10.1056/NEJMoa1605086DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5338864PMC
December 2016

The future of low-density lipoprotein cholesterol lowering therapy: An end to statin exceptionalism?

Eur J Prev Cardiol 2016 07 12;23(10):1062-4. Epub 2015 Aug 12.

Center for Human Genetic Research and Cardiovascular Research Center, Massachusetts General Hospital, Boston, USA.

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http://dx.doi.org/10.1177/2047487315600818DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6344937PMC
July 2016

Potent peroxisome proliferator-activated receptor-α agonist treatment increases cholesterol efflux capacity in humans with the metabolic syndrome.

Eur Heart J 2015 Nov 25;36(43):3020-2. Epub 2015 Jun 25.

Department of Medicine and Cardiovascular Institute, Perelman School of Medicine, Philadelphia, PA, USA

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http://dx.doi.org/10.1093/eurheartj/ehv291DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4644252PMC
November 2015

On-Statin Resistin, Leptin, and Risk of Recurrent Coronary Events After Hospitalization for an Acute Coronary Syndrome (from the Pravastatin or Atorvastatin Evaluation and Infection Therapy-Thrombolysis in Myocardial Infarction 22 Study).

Am J Cardiol 2015 Sep 4;116(5):694-8. Epub 2015 Jun 4.

Department of Medicine and Cardiovascular Institute, Perelman School of Medicine, 11-125 Smillow Center for Translational Research, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1016/j.amjcard.2015.05.038DOI Listing
September 2015

Plasma apolipoprotein C-III levels, triglycerides, and coronary artery calcification in type 2 diabetics.

Arterioscler Thromb Vasc Biol 2015 Aug 11;35(8):1880-8. Epub 2015 Jun 11.

From the Department of Medicine, Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia (A.Q., S.A.K., D.J.R., M.P.R.); Cardiology Division, Department of Medicine, Massachusetts General Hospital, Boston (A.V.K.); and Division of Cardiology, Department of Medicine, University of California at San Francisco (A.Q.).

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http://dx.doi.org/10.1161/ATVBAHA.115.305415DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4556282PMC
August 2015

Effects of niacin, statin, and fenofibrate on circulating proprotein convertase subtilisin/kexin type 9 levels in patients with dyslipidemia.

Am J Cardiol 2015 Jan 31;115(2):178-82. Epub 2014 Oct 31.

Department of Medicine, Smilow Center for Translational Research, Perelman School of Medicine, Philadelphia, Pennsylvania; Cardiovascular Institute, Smilow Center for Translational Research, Perelman School of Medicine, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1016/j.amjcard.2014.10.018DOI Listing
January 2015

Single-cell transcriptomics: an emerging tool in the study of cardiometabolic disease.

J Transl Med 2014 Nov 6;12:312. Epub 2014 Nov 6.

Section of Inflammation and Cardiometabolic Diseases, National Heart, Lung and Blood Institute, Bethesda, MD, 20892, USA.

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http://dx.doi.org/10.1186/s12967-014-0312-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4228185PMC
November 2014

Lipoprotein(a) concentrations, rosuvastatin therapy, and residual vascular risk: an analysis from the JUPITER Trial (Justification for the Use of Statins in Prevention: an Intervention Trial Evaluating Rosuvastatin).

Circulation 2014 Feb 17;129(6):635-42. Epub 2013 Nov 17.

Division of Preventive Medicine (A.V.K., B.M.E., P.M.R., S.M.) and Division of Cardiovascular Medicine (B.M.E., P.M.R., S.M.), Brigham and Women's Hospital, Harvard Medical School, Boston, MA; and Quest Diagnostics Nichols Institute, San Juan Capistrano, CA (M.P.C., F.M.H., J.W.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.113.004406DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3946056PMC
February 2014

Anti-oxidative and cholesterol efflux capacities of high-density lipoprotein are reduced in ischaemic cardiomyopathy.

Eur J Heart Fail 2013 Nov 24;15(11):1215-9. Epub 2013 May 24.

Division of Cardiology, Department of Medicine, Hospital of the University of Pennsylvania, University of Pennsylvania School of Medicine, Philadelphia, PA, USA.

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http://dx.doi.org/10.1093/eurjhf/hft084DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3888304PMC
November 2013

The addition of niacin to statin therapy improves high-density lipoprotein cholesterol levels but not metrics of functionality.

J Am Coll Cardiol 2013 Nov 7;62(20):1909-10. Epub 2013 Aug 7.

Department of Medicine, Brigham & Women's Hospital, Boston, Massachusetts. Electronic address:

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http://dx.doi.org/10.1016/j.jacc.2013.07.025DOI Listing
November 2013

Cholesterol efflux capacity: full steam ahead or a bump in the road?

Arterioscler Thromb Vasc Biol 2013 Jul;33(7):1449-51

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http://dx.doi.org/10.1161/ATVBAHA.113.301519DOI Listing
July 2013

Management of low levels of high-density lipoprotein-cholesterol.

Circulation 2013 Jul;128(1):72-8

Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, 77 Ave Louis Pasteur, NRB 742, Boston, MA 02115, USA.

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http://dx.doi.org/10.1161/CIRCULATIONAHA.112.000443DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4231714PMC
July 2013

Fasting for lipid testing: Is it worth the trouble?

Arch Intern Med 2012 Dec;172(22):1710-2

Department of Medicine, Brigham and Women’s Hospital, Boston, MA 02215, USA.

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December 2012

The anti-oxidative capacity of high-density lipoprotein is reduced in acute coronary syndrome but not in stable coronary artery disease.

J Am Coll Cardiol 2011 Nov;58(20):2068-75

Division of Cardiovascular Medicine, Department of Medicine, Hospital of University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S07351097110313
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http://dx.doi.org/10.1016/j.jacc.2011.08.030DOI Listing
November 2011

The novel atherosclerosis locus at 10q11 regulates plasma CXCL12 levels.

Eur Heart J 2011 Apr 17;32(8):963-71. Epub 2011 Mar 17.

Penn Cardiovascular Institute, University of Pennsylvania School of Medicine, Penn Tower, 6th Floor, 3400 Civic Center Blvd, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1093/eurheartj/ehr091DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3076669PMC
April 2011

Accuracy of noninvasively determined pulmonary artery systolic pressure.

Am J Cardiol 2010 Apr 5;105(8):1192-7. Epub 2010 Mar 5.

Cardiovascular Division, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA.

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http://dx.doi.org/10.1016/j.amjcard.2009.11.048DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2994808PMC
April 2010

Future therapeutic directions in reverse cholesterol transport.

Curr Atheroscler Rep 2010 Jan;12(1):73-81

Institute for Translational Medicine and Therapeutics and Cardiovascular Institute, University of Pennsylvania, Philadelphia, PA, USA.

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http://link.springer.com/10.1007/s11883-009-0080-0
Publisher Site
http://dx.doi.org/10.1007/s11883-009-0080-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3315100PMC
January 2010

Discovery and validation of new molecular targets in treating dyslipidemia: the role of human genetics.

Trends Cardiovasc Med 2009 Aug;19(6):195-201

Institute for Translational Medicine & Therapeutics and Cardiovascular Institute, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1016/j.tcm.2009.12.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3328807PMC
August 2009

My most famous patient. (Second-place essay at the Francis A. Velay Humanism in Medicine Essay Contest presented by the Arnold P. Gold Foundation).

Authors:
Amit V Khera

Acad Med 2008 Dec;83(12):1170-1

University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1097/ACM.0b013e31818c674eDOI Listing
December 2008

Monkeys pay per view: adaptive valuation of social images by rhesus macaques.

Curr Biol 2005 Mar;15(6):543-8

Department of Neurobiology, Duke University Medical Center, Durham, North Carolina 27710, USA.

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http://dx.doi.org/10.1016/j.cub.2005.01.044DOI Listing
March 2005