Amit Dutt

Dr. Amit Dutt

Ph.D.

ACTREC, Tata Memorial Center

Principal Investigator/ Assistant professor

Mumbai, Maharastra | India

Specialties: Cancer Genomics

Amit Dutt

Dr. Amit Dutt

Ph.D.
Introduction

Dr. Dutt is a Principal Investigator (Scientist F) at Tata Memorial Center, Mumbai. Dr. Dutt did his Ph.D from Univ. of Zurich, and postdoc at theBroad Institute of MIT and Harvard, Boston. The focus of his lab is to study the alterations underlying the human cancer genome using advanced sequencing and functional genomics approaches; to study the pathogens associated with human cancer; and, develop novel computational approaches to analyze high throughput cancer genome dataset. Dr. Dutt's laboratory has pioneered EGFR and KRAS mutation profiling in lung cancer patients of Indian origin; developed computational tools like “HPVDetector”, “TMC-SNPdb" and experimental tools like "CRE" with application in clinical diagnostics at the TMH. Dr. Dutt's postdoctoral work in the laboratory of Matthew Meyerson led to the discovery of somatic FGFR2 mutation in endometrial cancer; amplification of FGFR1 in lung squamous cell carcinoma; and, amplification of PDGFRA in lung cancer.

Primary Affiliation: ACTREC, Tata Memorial Center - Mumbai, Maharastra , India

Specialties:

Research Interests:


View Dr. Amit Dutt’s Resume / CV
Metrics

38

Publications

222

Profile Views

372

Reads

2138

PubMed Central Citations

Top co-authors
Matthew Meyerson
Matthew Meyerson

Dana-Farber Cancer Institute

9
Pawan Upadhyay
Pawan Upadhyay

Tata Memorial Center

8
Pratik Chandrani
Pratik Chandrani

Tata Memorial Hospital

7
Nilesh Gardi
Nilesh Gardi

Integrated Genomics Laboratory

7
Heidi Greulich
Heidi Greulich

Dana-Farber Cancer Institute

5
Alex H Ramos
Alex H Ramos

Dana-Farber Cancer Institute

5
Sudeep Gupta
Sudeep Gupta

Tata Memorial Hospital

5
Rohan Chaubal
Rohan Chaubal

Tata Memorial Center

5
Jeonghee Cho
Jeonghee Cho

Dana-Farber Cancer Institute

4
Kumar Prabhash
Kumar Prabhash

Tata Memorial Hospital

4

Publications

38Publications

372Reads

2138PubMed Central Citations

TMC-SNPdb: an Indian germline variant database derived from whole exome sequences.

Database (Oxford) 2016 9;2016. Epub 2016 Jul 9.

Integrated Genomics Laboratory, Advanced Centre for Treatment Research Education in Cancer (ACTREC)

View Article
November 2017
8 Reads
2 PubMed Central Citations(source)
3.37 Impact Factor

miR-129-2 mediates down-regulation of progesterone receptor in response to progesterone in breast cancer cells.

Cancer Biol Ther 2017 Oct 6;18(10):801-805. Epub 2017 Sep 6.

a Integrated Genomics Laboratory, Advanced Centre for Treatment, Research and Education In Cancer, Tata Memorial Centre , Maharashtra , Navi Mumbai , India.

View Article
October 2017
4 Reads
3.07 Impact Factor

Genomic characterization of tobacco/nut chewing HPV-negative early stage tongue tumors identify MMP10 asa candidate to predict metastases.

Oral Oncol 2017 10 12;73:56-64. Epub 2017 Aug 12.

Integrated Genomics Laboratory, ACTREC, Tata Memorial Centre, Navi Mumbai 410210, India; Homi Bhabha National Institute, Training School Complex, Anushakti Nagar, Mumbai 400094, India. Electronic address:

View Article
October 2017
4 Reads
3.61 Impact Factor

Impact of intra-tumoral IL17A and IL32 gene expression on T-cell responses and lymph node status in breast cancer patients.

J Cancer Res Clin Oncol 2017 Sep 3;143(9):1745-1756. Epub 2017 May 3.

Cancer Research Institute, Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Tata Memorial Centre, Kharghar, Navi Mumbai, Maharashtra, 410210, India.

View Article
September 2017
2 Reads
3.08 Impact Factor

Progesterone suppresses the invasion and migration of breast cancer cells irrespective of their progesterone receptor status - a short report.

Cell Oncol (Dordr) 2017 Aug 26;40(4):411-417. Epub 2017 Jun 26.

Integrated Genomics Laboratory, Advanced Centre for Treatment, Research and Education In Cancer, Tata Memorial Centre, Navi Mumbai, 410210, India.

View Article
August 2017
5 Reads
3.03 Impact Factor

Drug-sensitive FGFR3 mutations in lung adenocarcinoma.

Ann Oncol 2017 03;28(3):597-603

Integrated Genomics Laboratory, Advanced Centre for Treatment, Research and Education in Cancer, Tata Memorial Centre, Navi Mumbai, India.

View Article
March 2017
6 Reads
2 PubMed Central Citations(source)
7.04 Impact Factor

MYOD1 (L122R) mutations are associated with spindle cell and sclerosing rhabdomyosarcomas with aggressive clinical outcomes.

Mod Pathol 2016 Dec 26;29(12):1532-1540. Epub 2016 Aug 26.

Integrated Genomics Laboratory, Advanced Centre for Treatment, Research and Education In Cancer, Tata Memorial Centre, Navi Mumbai, Maharashtra, India.

View Article
December 2016
2 Reads
1 PubMed Central Citation(source)
6.19 Impact Factor

To improve outcomes of gallbladder cancer we need to better understand it!

Hepatobiliary Surg Nutr 2016 Aug;5(4):379-81

The Advanced Centre for Treatment, Research and Education in Cancer, Tata Memorial Center, Kharghar, Navi Mumbai, Maharashtra, India.

View Article
August 2016
1 Read

Notch pathway activation is essential for maintenance of stem-like cells in early tongue cancer.

Oncotarget 2016 Aug;7(31):50437-50449

Integrated Genomics Laboratory, Advanced Centre for Treatment, Research and Education In Cancer, Tata Memorial Centre, Navi Mumbai- 410210, India.

View Article
August 2016
10 Reads
5 PubMed Central Citations(source)
6.36 Impact Factor

Unique spectral markers discern recurrent Glioblastoma cells from heterogeneous parent population.

Sci Rep 2016 05 25;6:26538. Epub 2016 May 25.

Shilpee Dutt Laboratory, Tata Memorial Centre, Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Kharghar, Navi Mumbai 410210, India.

View Article
May 2016
2 Reads
5.08 Impact Factor

CRE: a cost effective and rapid approach for PCR-mediated concatenation of KRAS and EGFR exons: Rapid way to detect EGFR and KRAS mutations.

F1000Res 2015 23;4:160. Epub 2015 Jun 23.

Advanced Centre for Treatment, Research and Education in Cancer, Tata Memorial Centre, Navi Mumbai, Maharashtra, 410210, India.

View Article
May 2016
3 Reads
1 PubMed Central Citation(source)

Non-typhoidal Salmonella DNA traces in gallbladder cancer.

Infect Agent Cancer 2016 3;11:12. Epub 2016 Mar 3.

Advanced Centre for Treatment, Research and Education in Cancer, Kharghar, Navi Mumbai India.

View Article
March 2016
1 Read
2 PubMed Central Citations(source)
2.07 Impact Factor

Integrated genomics approach to identify biologically relevant alterations in fewer samples.

BMC Genomics 2015 Nov 14;16:936. Epub 2015 Nov 14.

Advanced Centre for Treatment, Research and Education in Cancer, Tata Memorial Center, Navi Mumbai, Maharashtra, 410210, India.

View Article
November 2015
3 Reads
2 PubMed Central Citations(source)
3.99 Impact Factor

The fight against cancer: Is it worthwhile?

Indian J Med Paediatr Oncol 2015 Apr-Jun;36(2):85-6

The Advanced Centre for Treatment, Research and Education in Cancer, Tata Memorial Center, Kharghar, Navi Mumbai, Maharashtra, India.

View Article
July 2015
3 Reads

NGS-based approach to determine the presence of HPV and their sites of integration in human cancer genome.

Br J Cancer 2015 Jun 14;112(12):1958-65. Epub 2015 May 14.

Advanced Centre for Treatment, Research and Education in Cancer, Tata Memorial Centre, Kharghar, Navi Mumbai, Maharashtra 410210, India.

View Article
June 2015
1 Read
10 PubMed Central Citations(source)
4.84 Impact Factor

Circulating nucleic acids damage DNA of healthy cells by integrating into their genomes.

J Biosci 2015 Mar;40(1):91-111

Translational Research Laboratory, Advanced Centre for Treatment, Research and Education in Cancer, Tata Memorial Centre, Kharghar, Navi Mumbai 410210, India,

View Article
March 2015
18 Reads
10 PubMed Central Citations(source)
2.06 Impact Factor

Coexistence of KRAS mutation with mutant but not wild-type EGFR predicts response to tyrosine-kinase inhibitors in human lung cancer.

Br J Cancer 2014 Nov 12;111(11):2203-4. Epub 2014 Aug 12.

Advanced Centre for Treatment, Research and Education in Cancer, Tata Memorial Center, Navi Mumbai, India.

View Article
November 2014
2 Reads
10 PubMed Central Citations(source)
4.84 Impact Factor

Frequency of EGFR mutations in 907 lung adenocarcioma patients of Indian ethnicity.

PLoS One 2013 4;8(10):e76164. Epub 2013 Oct 4.

Department of Medical Oncology, Tata Memorial Hospital, Tata Memorial Center, Mumbai, Maharashtra, India.

View Article
July 2014
2 Reads
21 PubMed Central Citations(source)
3.23 Impact Factor

A genetic model for gallbladder carcinogenesis and its dissemination.

Ann Oncol 2014 Jun 4;25(6):1086-97. Epub 2014 Apr 4.

Department of Gastrointestinal Surgery, Gastrointestinal Oncology, and Bariatric Surgery, Medanta Institute of Digestive and Hepatobiliary Sciences, Medanta, The Medicity, Gurgaon.

View Article
June 2014
1 Read
10 PubMed Central Citations(source)
7.04 Impact Factor

EGFR mutations in Indian lung cancer patients: clinical correlation and outcome to EGFR targeted therapy.

PLoS One 2013 19;8(4):e61561. Epub 2013 Apr 19.

Department of Medical Oncology, Tata Memorial Hospital, Tata Memorial Center, Mumbai, India.

View Article
November 2013
2 Reads
12 PubMed Central Citations(source)
3.23 Impact Factor

Inhibitor-sensitive FGFR1 amplification in human non-small cell lung cancer.

PLoS One 2011 7;6(6):e20351. Epub 2011 Jun 7.

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America.

View Article
December 2011
7 Reads
117 PubMed Central Citations(source)
3.23 Impact Factor

A structure-guided approach to creating covalent FGFR inhibitors.

Chem Biol 2010 Mar;17(3):285-95

Department of Cancer Biology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.

View Article
March 2010
3 Reads
26 PubMed Central Citations(source)
6.64 Impact Factor

Amplification of chromosomal segment 4q12 in non-small cell lung cancer.

Cancer Biol Ther 2009 Nov 7;8(21):2042-50. Epub 2009 Nov 7.

Department of Medical Oncology and Center for Cancer Genome Discovery, Dana-Farber Cancer Institute, Boston, MA, USA.

View Article
November 2009
6 Reads
31 PubMed Central Citations(source)
3.07 Impact Factor

Somatic mutations affect key pathways in lung adenocarcinoma.

Nature 2008 Oct;455(7216):1069-75

The Genome Center at Washington University, Department of Genetics, Washington University School of Medicine, St Louis, Missouri 63108, USA.

View Article
October 2008
188 Reads
886 PubMed Central Citations(source)
42.35 Impact Factor

Drug-sensitive FGFR2 mutations in endometrial carcinoma.

Proc Natl Acad Sci U S A 2008 Jun 13;105(25):8713-7. Epub 2008 Jun 13.

Department of Medical Oncology and Center for Cancer Genome Discovery, Dana-Farber Cancer Institute, Boston, MA 02115, USA.

View Article
June 2008
20 Reads
103 PubMed Central Citations(source)
9.81 Impact Factor

Single nucleotide polymorphism array analysis of cancer.

Curr Opin Oncol 2007 Jan;19(1):43-9

Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge 02142, USA.

View Article
January 2007
4 Reads
36 PubMed Central Citations(source)
4.47 Impact Factor

A study on p53 gene alterations in esophageal squamous cell carcinoma and their correlation to common dietary risk factors among population of the Kashmir valley.

World J Gastroenterol 2006 Jul;12(25):4033-7

Division of PHT, SKUAST (K), Shalimar Campus, Srinagar, Kashmir, 191121 (J and K), India.

View Article
July 2006
4 Reads
15 PubMed Central Citations(source)
2.37 Impact Factor

A preliminary investigation demonstrating the effect of quercetin on the expression of genes related to cell-cycle arrest, apoptosis and xenobiotic metabolism in human CO115 colon-adenocarcinoma cells using DNA microarray.

Biotechnol Appl Biochem 2006 Jul;45(Pt 1):29-36

Biochemistry and Molecular Biotechnology Laboratory, Division of PHT, SK University of Agricultural Sciences and Technology, Shalimar Campus, Srinagar, Kashmir, India.

View Article
July 2006
3 Reads
3 PubMed Central Citations(source)
1.36 Impact Factor

Molecular cloning and genetic analysis of functional merB gene from indian isolates of Escherichia coli.

Curr Microbiol 2005 Nov 5;51(5):297-302. Epub 2005 Oct 5.

Molecular Biotechnology and Biochemistry Laboratory, Division of PHT, S.K University of Agricultural Sciences and Technology of Kashmir, Shalimar Campus, Srinagar, Kashmir, India.

View Article
November 2005
1 Read
1.42 Impact Factor

EGF signal propagation during C. elegans vulval development mediated by ROM-1 rhomboid.

PLoS Biol 2004 Nov 28;2(11):e334. Epub 2004 Sep 28.

Zoologisches Institut, Universität Zurich, Zurich, Switzerland.

View Article
November 2004
17 PubMed Central Citations(source)

Relationship between the persistence of mer operon sequences in Escherichia coli and their resistance to mercury.

Curr Microbiol 2002 Mar;44(3):178-83

Gene Expression Laboratory, Department of Biosciences, Jamia Millia Islamia, New Delhi-110 025, India.

View Article
March 2002
2 Reads
1.42 Impact Factor
Top co-authors
Matthew Meyerson
Matthew Meyerson

Dana-Farber Cancer Institute

9
Pawan Upadhyay
Pawan Upadhyay

Tata Memorial Center

8
Pratik Chandrani
Pratik Chandrani

Tata Memorial Hospital

7
Nilesh Gardi
Nilesh Gardi

Integrated Genomics Laboratory

7
Heidi Greulich
Heidi Greulich

Dana-Farber Cancer Institute

5
Alex H Ramos
Alex H Ramos

Dana-Farber Cancer Institute

5
Sudeep Gupta
Sudeep Gupta

Tata Memorial Hospital

5
Rohan Chaubal
Rohan Chaubal

Tata Memorial Center

5
Jeonghee Cho
Jeonghee Cho

Dana-Farber Cancer Institute

4
Kumar Prabhash
Kumar Prabhash

Tata Memorial Hospital

4