Biography

Dr. Dutt is a Principal Investigator (Scientist F) at Tata Memorial Center, Mumbai. Dr. Dutt did his Ph.D from Univ. of Zurich, and postdoc at theBroad Institute of MIT and Harvard, Boston. The focus of his lab is to study the alterations underlying the human cancer genome using advanced sequencing and functional genomics approaches; to study the pathogens associated with human cancer; and, develop novel computational approaches to analyze high throughput cancer genome dataset. Dr. Dutt's laboratory has pioneered EGFR and KRAS mutation profiling in lung cancer patients of Indian origin; developed computational tools like “HPVDetector”, “TMC-SNPdb" and experimental tools like "CRE" with application in clinical diagnostics at the TMH. Dr. Dutt's postdoctoral work in the laboratory of Matthew Meyerson led to the discovery of somatic FGFR2 mutation in endometrial cancer; amplification of FGFR1 in lung squamous cell carcinoma; and, amplification of PDGFRA in lung cancer.

Primary Affiliation: ACTREC, Tata Memorial Center - Mumbai, Maharastra , India

Specialties: Cancer Genomics

Research Interests: Characterisation of Somatic alterations underlying the human cancer genome using Genomic and Functional genomic approaches; pathogen discovery in clinical cancer specimen; development of computational tools to analyse of high throughput data generated using advanced sequencing technologies

Publications

miR-129-2 mediates down-regulation of progesterone receptor in response to progesterone in breast cancer cells.
Cancer Biol Ther 2017 Oct 6;18(10):801-805. Epub 2017 Sep 6.
a Integrated Genomics Laboratory, Advanced Centre for Treatment, Research and Education In Cancer, Tata Memorial Centre , Maharashtra , Navi Mumbai , India.

Impact of intra-tumoral IL17A and IL32 gene expression on T-cell responses and lymph node status in breast cancer patients.
J Cancer Res Clin Oncol 2017 May 3. Epub 2017 May 3.
Cancer Research Institute, Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Tata Memorial Centre, Kharghar, Navi Mumbai, Maharashtra, 410210, India.


Unique spectral markers discern recurrent Glioblastoma cells from heterogeneous parent population.
Sci Rep 2016 May 25;6:26538. Epub 2016 May 25.
Shilpee Dutt Laboratory, Tata Memorial Centre, Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Kharghar, Navi Mumbai 410210, India.

Integrated genomics approach to identify biologically relevant alterations in fewer samples.
BMC Genomics 2015 Nov 14;16:936. Epub 2015 Nov 14.
Advanced Centre for Treatment, Research and Education in Cancer, Tata Memorial Center, Navi Mumbai, Maharashtra, 410210, India.







Somatic mutations affect key pathways in lung adenocarcinoma.
Nature 2008 Oct;455(7216):1069-75
The Genome Center at Washington University, Department of Genetics, Washington University School of Medicine, St Louis, Missouri 63108, USA.







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