Publications by authors named "Amir Ziaee"

36 Publications

Evaluate the prevalence of depression in type 2 diabetics with microvascular complications.

J Family Med Prim Care 2020 Jun 30;9(6):3060-3064. Epub 2020 Jun 30.

Department of Internal Medicine, School of Medicine, Hazrat-e Rasool Hospital, Iran University of Medical Sciences, Tehran, Iran.

Introduction: Diabetes is one of the most common diseases in the world that is accompanied with many microvascular complications. Any chronic disease such as diabetes can cause types of mood disorders such as depression in patients. The aim of this study was to evaluate the prevalence of depression in type 2 diabetics with microvascular complications.

Execution Method: In this cross-sectional study, type 2 diabetics with microvascular complications that referred to Hazrat Rasoul Akram Hospital during 2016-2017 were studied. After verification of retinopathy and nephropathy in patients, 100 patients were enrolled in the study and correlated between variables such as age, sex, body mass index, medication, education, retinopathy, nephropathy, marital status, hemoglobin A1c (HbA1c), triglyceride, low-density lipoprotein (LDL) and high-density lipoprotein (HDL), blood pressure, and fasting blood sugar was investigated in patients given the possibility of depression.

Results: The results of this study showed that 72% of patients were with depression and by evaluating the mentioned variables with depression disorder it was found that there was a significant relationship between fasting blood sugar, HbA1C, retinopathy, medication, and LDL with depression.

Conclusion: Given the high prevalence of depression (72%) in diabetics in this study, it seems that psychiatric consultation is needed to diagnose depression in diabetics.
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http://dx.doi.org/10.4103/jfmpc.jfmpc_123_20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7491778PMC
June 2020

Application of modified electrospun nanofiber membranes with α-FeO nanoparticles in arsenate removal from aqueous media.

Environ Sci Pollut Res Int 2019 Jul 29;26(21):21993-22009. Epub 2019 May 29.

Division of Sustainable Development, College of Science and Engineering, Hamad Bin Khalifa University, Education City, Qatar Foundation, Doha, Qatar.

In the present study, electrospun nanofiber membranes (ENMs) of polyacrylonitrile (PAN) were modified by dispersing α-FeO nanoparticles, synthesized using a thermal solvent process, in a PAN solution. The morphology and physiochemical properties of the prepared ENMs and the α-FeO were characterized using FESEM, EDX, BET, XRD, FTIR, porosity, and contact angle measurement. XPS was used to investigate the interaction of ENM with arsenate (As(V)) during the adsorption. Moreover, the effect of pH, the equilibrium isotherm, and the kinetics were investigated in batch experiments. The Langmuir isotherm best correlated the experimental results, indicating monolayer adsorption on ENMs, and the kinetics was best fitted, R > 0.99, by the pseudo-second-order model. In addition, the effects of certain conditions on the filtration performance were examined, such as feed concentration and transmembrane pressure (TMP). By passing sodium hydroxide (0.1 M) for 20 min, the membrane was regenerated. The increase in TMP, along with the presence of co-ions including chloride, nitrate, and sulfate, had negative impacts on the removal of As(V). The results show that the modified ENMs with α-FeO nanoparticles are applicable for As(V) ion removal and possibly for eliminating other heavy metals from aqueous media.
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http://dx.doi.org/10.1007/s11356-019-05228-5DOI Listing
July 2019

Changes in the size of the thyroid in patients with benign non-toxic multinodular goiter after radioactive iodine therapy.

Med J Islam Repub Iran 2018 27;32:131. Epub 2018 Dec 27.

Pediatric Growth and Development Research Center, Institute of Endocrinology and Metabolism ,Iran University of Medical Sciences Tehran, Iran.

Multinodular goiter (MNG) is regarded as one of the most common causes of hyperthyroidism, particularly in areas of mild-to-moderate iodine deficiency. The present study aims to explore the effects of the radioactive iodine (RAI) therapy on benign non-toxic MNG and evaluate its side effects. Patients with benign non-toxic MNG entered the study. Ultrasonography was applied to calculate the percentage of the decrease in the size of the thyroid before and six months minimum after the treatment. Chi-square, Mann-Whiteny-U and T-test were done using SPSS v.18.0 (p<0.05). The volumes of the thyroid lobes and nodules decreased significantly due to RAI therapy (p<0.001). The total volume of the thyroid, volume of the right nodule, and volume of the left nodule decreased by 77.8%, 40.7%, and 34.6% respectively. According to the results of the current study, RAI therapy is an effective treatment method although it has short-term side effects. This treatment option is recommended for patients with benign non-toxic MNG, notably those who cannot be a candidate for surgery. This treatment affects the size of the thyroid and its nodules significantly and decreases almost all of the complications.
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http://dx.doi.org/10.14196/mjiri.32.131DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6387795PMC
December 2018

Association of hematological indices with prediabetes: A cross-sectional study.

Electron Physician 2017 Sep 25;9(9):5206-5211. Epub 2017 Sep 25.

MD., General Practitioner, Tehran, Iran.

Background: Prediabetes is a condition that occurs when blood glucose levels are higher than normal, but not high enough to be classified as diabetes. Prediabetic people have an increased risk of developing type 2 diabetes and cardiovascular disease. Moreover Hyperglycemia has multiple effects on the hematological parameters.

Objective: To examine the association between hematological indices and anthropometric measurement, with prediabetes.

Methods: This cross-sectional study was conducted on 125 diabetics and 259 prediabetics in the 20-70 age range. They were selected by a convenience sampling method at the Taban Diabetes Center in 2015. An oral glucose tolerance test was performed for each participant who had never been diagnosed with diabetes. Participants were characterized as having prediabetes or diabetes according to American Diabetes Association criteria. The hematologic parameters were measured by using Sysmex-KX 21N analyzers. Data were analyzed by IBM-SPSS version 22 using independent-samples t-test, Mann-Whitney U test, and Pearson's correlation coefficient at p<0.05.

Results: There was significant difference in mean corpuscular hemoglobin concentration (MCVH) (33.81±0.92 g/dL vs. 34.06±1.05 g/dL) between prediabetes patients and diabetes. There was not a statistically significant difference in the prediabetics' hematological parameters, compared with the diabetics. In the prediabetic group, only the mean corpuscular hemoglobin concentration was found to be negatively correlated with diastolic blood pressure (p=0.013) and FBS (p=0.026).

Conclusion: Hematological indices are important markers for the assessment of variations in size, number, and maturity of different blood cells. Hematological indices could be utile indicators of vascular complication and glycemic control in type 2 DM patients. Thus, they are important for the evaluation and early management of patients with per diabetes.
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http://dx.doi.org/10.19082/5206DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5633214PMC
September 2017

Comparison of adjunctive therapy with metformin and acarbose in patients with Type-1 diabetes mellitus.

Pak J Med Sci 2017 May-Jun;33(3):686-690

Maryam Honardoost, Assistant Professor of Molecular Medicine, Endocrine Research Center, Institute of Endocrinology and Metabolism, ran University of Medical Sciences, Tehran, Iran.

Objective: All the aforementioned data have stimulated interest in studying other potential therapies for T1DM including noninsulin pharmacological therapies. The present study attempts to investigate the effect of adjunctive therapy with metformin and acarbose in patients with Type-1 diabetes mellitus.

Method: In a single-center, placebo-controlled study (IRCT201102165844N1) we compared the results of two clinical trials conducted in two different time periods on 40 patients with Type-1 diabetes mellitus. In the first section, metformin was given to the subjects. After six months, metformin was replaced with acarbose in the therapeutic regimen. In both studies, subjects were checked for their BMI, FBS, HbA1C, TGs, Cholesterol, LDL, HDL, 2hpp, unit of NPH and regular insulin variations.

Results: Placebo-controlled evaluation of selected factors has showna significant decrease in FBS and TG levels in the metformin group during follow up but acarbose group has shown substantial influence on two hour post prandial (2hpp) and regular insulin intake decline. Moreover, Comparison differences after intervention between two test groups has shown that metformin has had superior impact on FBS and HbA1C decline in patients. Nonetheless, acarbose treatment had noteworthy influence on 2hpp, TGs, Cholesterol, LDL, and regular insulin intake control.

Conclusion: The results of this experiment demonstrate that the addition of acarbose or metformin to patients with Type-1 diabetes mellitus who are controlled with insulin is commonly well tolerated and help to improve metabolic control in patients.
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http://dx.doi.org/10.12669/pjms.333.12669DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5510127PMC
August 2017

Awareness of osteoporosis among female head of household: an Iranian experience.

Arch Osteoporos 2017 Dec 6;12(1):36. Epub 2017 Apr 6.

Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.

More than 81% of the studied women had a poor knowledge of different aspects of osteoporosis and its complications, suggesting that more educational programs targeting women in particular are needed to help improve the osteoporosis practice in the societies and reduce the burden of the disease.

Purpose: The family structure has changed considerably in the past decade. But, women from Iran and many countries in the region and even families with similar cultural background living in other parts of the world are still responsible for childcare as well as the lifestyle adapted by the family. The present study was conducted to assess the awareness of the female head of household of osteoporosis and its complications.

Methods: As part of a population-based study in two Iranian cities, Arak and Sannandaj, to study osteoporosis and its risk factors, a questionnaire on the knowledge of female head of households of osteoporosis and its complications was completed. The subsample filled out the knowledge survey along with the questionnaire on their demographic data, socioeconomic status (SES), reproductive factors, bone-related lifestyle habits, family and personal medical history, medication use, and compliance with osteoporosis medication (if used) as well as a FFQ filled out for all the 2100 participants. They also underwent a bone mineral density (BMD) test, and their serum levels of vitamin D were calculated. These data were then used to assess the factors affecting their awareness level.

Results: The knowledge of 81.3% (473) of the studied women was found to be poor on different aspects of osteoporosis and its complications. Multivariate analysis revealed that each level increase in vit D intake tertile increases the chance of higher awareness level in K-Total by 1.5 times. Each level increase in physical activity tertile was associated with a 30.6% lower chance of having a good knowledge.

Conclusion: Considering the poor awareness level of the studied women and their poor practice of bone healthy behavior, one could conclude that more programs are needed or the content/delivery style of the existing ones should be optimized.
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http://dx.doi.org/10.1007/s11657-017-0330-7DOI Listing
December 2017

Association of sleep quality components and wake time with metabolic syndrome: The Qazvin Metabolic Diseases Study (QMDS), Iran.

Diabetes Metab Syndr 2017 Nov 6;11 Suppl 1:S377-S380. Epub 2017 Mar 6.

Metabolic Diseases Research Center, Qazvin University of Medical Sciences, Qazvin, Iran.

Purpose: The aim of this study was to determine the association of sleep quality and sleep quantity with metabolic syndrome in Qazvin, Iran.

Methods: this cross sectional study was conducted in 1079 residents of Qazvin selected by multistage cluster random sampling method in 2011. Metabolic syndrome was defined according to the criteria proposed by the national cholesterol education program third Adult treatment panel. Sleep was assessed using the Pittsburgh sleep quality index (PSQI). A logistic regression analysis was used to examine the association of sleep status and metabolic syndrome.

Results: Mean age was 40.08±10.33years. Of 1079, 578 (52.2%) were female, and 30.6% had metabolic syndrome. The total global PSQI score in the subjects with metabolic syndrome was significantly higher than subjects without metabolic syndrome (6.30±3.20 vs. 5.83±2.76, P=0.013). In logistic regression analysis, sleep disturbances was associated with 1.388 fold increased risk of metabolic syndrome after adjustment for age, gender, and body mass index.

Conclusion: Sleep disturbances component was a predictor of metabolic syndrome in the present study. More longitudinal studies are necessary to understand the association of sleep quality and its components with metabolic syndrome.
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http://dx.doi.org/10.1016/j.dsx.2017.03.020DOI Listing
November 2017

Association of meat and dairy consumption with normal weight metabolic obesity in men: the Qazvin Metabolic Diseases Study.

Eat Weight Disord 2016 Sep 4;21(3):419-425. Epub 2016 Jan 4.

Metabolic Diseases Research Center, Qazvin University of Medical Sciences, Qazvin, Iran.

Background: Insulin resistance (IR) is not limited to obese individuals. Normal weight individuals may also be insulin resistant. The aim of this study was to determine the association of lifestyle and diet patterns with IR in normal weight Iranian men.

Methods: This cross-sectional study was conducted in 232 men with a body mass index lower than 25 kg/m(2) (aged 20-72 years old) between September 2010 and April 2011 in Qazvin, Iran. Metabolically obese normal weight (MONW) was defined as IR using the homeostatic model assessment (HOMA). The optimal cut point to diagnose IR was the 80th percentile of HOMA-IR values in normal subjects. The HOMA-IR cut point was 2.48. Dietary pattern was assessed by a semi-quantitative food frequency questionnaire. Data were analyzed using backward logistic regression and ANCOVA.

Results: Fat and meat consumption and energy intake in subjects with MONW were more than subjects without MONW. Each serving of meat consumption was associated with three times increased risk of MONW (OR: 3.06), while each serving of dairy consumption was associated with 56 % lower risk of MONW with borderline significance (OR: 0.64). Adjusted mean of HOMA-IR in the first tertile of dairy consumption was significantly higher than other tertiles. Adjusted HOMA-IR value in the third tertile of meat consumption was significantly higher than the second tertile.

Conclusion: Higher meat consumption was associated with MONW in men. Higher meat consumption and lower dairy consumption were associated with higher means of HOMA-IR.
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http://dx.doi.org/10.1007/s40519-015-0250-8DOI Listing
September 2016

Association of Sleep Quality and Waking Time with Prediabetes: The Qazvin Metabolic Diseases Study, Iran.

Sleep Disord 2015 16;2015:480742. Epub 2015 Aug 16.

Metabolic Diseases Research Center, Qazvin University of Medical Sciences, Qazvin 3413786165, Iran.

Aims. It is known that sleep has a major role in the regulation of endocrine functions and glucose metabolism. However, it is not clear whether the sleep pattern is affected at or prior to the onset of diabetes, among those with prediabetes. The purpose of this study was to determine the association of sleep patterns and prediabetes in Qazvin, Iran. Methods. A representative sample of residents of Qazvin was selected by multistage cluster random sampling method in 2011. Plasma glucose level and sleep quality were measured cross-sectionally as well as demographic characteristics. A logistic regression analysis was used to examine the association of sleep status and prediabetes. Results. Mean age was 39.3 ± 10.1 years. Of 958, 474 (49.47%) were female. Poor sleep quality was associated with 2.197-fold increased risk of prediabetes after adjustment for age, gender, body mass index, and metabolic syndrome. Conclusion. This study provides evidences that subjects with poor sleep quality are more likely to develop prediabetes than people with good sleep quality.
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http://dx.doi.org/10.1155/2015/480742DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4553331PMC
September 2015

The threshold value of homeostasis model assessment for insulin resistance in Qazvin Metabolic Diseases Study (QMDS): assessment of metabolic syndrome.

J Res Health Sci 2015 ;15(2):94-100

Metabolic Diseases Research Center, Qazvin University of Medical Sciences, Qazvin, Iran.

Background: The homeostasis model assessment of insulin resistance (HOMA-IR) is a useful model for application at large epidemiologic studies. The aim of this study was to determine the HOMA cut off values to identify insulin resistance (IR) and metabolic syndrome (MS) in Qazvin, central Iran.

Methods: Overall, 480 men and 502 women aged 20-72 yr attended in this cross sectional study from September 2010 to April 2011. The diagnostic criteria proposed by national cholesterol education program third adult treatment panel (ATPIII), International Diabetes Federation (IDF) and new Joint Interim Societies (JIS); were applied to define MS. Lower limit of the top quintile of HOMA values in normal subjects was considered as the threshold of IR. The receiver operating characteristic (ROC) curves of HOMA for MS diagnosis were depicted. The optimal cut point to determine MS was assessed by maximum Youden index and the shortest distance from the point (0, 1) on the ROC curve.

Results: The threshold of HOMA for IR was 2.48. Fifty one percent of the subjects were insulin resistant. The cut point for diagnosis of JIS, IDF, ATP III and Persian IDF defined MS was 2.92, 2.91, 2.49 and 3.21, respectively. Sensitivity and specificity of ATP III defined MS to diagnose IR was 33.95% and 84.78%, of IDF defined MS was 39.13%, 81.29% and of JIS defined MS was 43.77% and 78.11% and of Persian IDF defined MS was 27.32% and 88.76%, in that order.

Conclusions: The high prevalence of IR in the present study warns about the future burden of type 2 diabetes. Only the ATP III criteria introduced more specific cut point for putative manifestations of IR.
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April 2016

Association of serum 25-hydroxyvitamin d levels and vitamin D dietary intake with metabolic syndrome: a case control study.

J Res Health Sci 2015 ;15(1):32-6

Metabolic Diseases Research Center, Qazvin University of Medical Sciences, Qazvin, Iran.

Background: Association between the vitamin D deficiency and metabolic syndrome (MetS) has previously been noted and reported to be controversial. The aim of this study was to determine the association of serum 25 (OH) D Level and Vitamin D dietary intake with MetS among Iranian population.

Methods: This analytical study was conducted on 122 patients with MetS based on the ATPIII criteria and 128 subjects without MetS as control from September 2010 to April 2011. Serum levels of calcium, phosphorus and 25(OH) D were compared between the two groups. A food frequency questionnaire (FFQ) was used to calculate dietary intake. Data were analyzed using Chi- square test, t-test, Mann-Whitney U test and logistic regression analysis.

Results: Serum concentrations of 25 (OH) D, calcium and phosphorus and calcium intake were significantly lower in subjects with MetS compared to the subjects without MetS. 98.4% of subjects with MetS and 88.3% without MetS had Vit. D deficiency and this difference was statistically significant (P=0.005). In regression analysis, lower concentration of serum 25 (OH) D, calcium and phosphorus and lower calcium and diary intake were predictors of MetS.

Conclusions: Serum 25 (OH) D Level, calcium and phosphorus and calcium intake are associated with metabolic syndrome. However, the mechanism of this association requires further studies.
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December 2015

A Randomized Clinical Trial Study: Anti-Oxidant, Anti-hyperglycemic and Anti-Hyperlipidemic Effects of Olibanum Gum in Type 2 Diabetic Patients.

Iran J Pharm Res 2014 ;13(3):1003-9

School of Traditional Medicine, Tehran University of Medical Sciences, Tehran, Iran.

Diabetes is a common metabolic disease in the world that has many adverse effects. Olibanum gum resin (from trees of the genus Boswellia) has traditionally been used in the treatment of various diseases such as diabetes. The aim of this study was the comparison of Olibanum gum resin effect with placebo on the treatment of type 2 diabetes. Inclusion criteria was diabetic patients with fasting blood sugar (FBS) =140-200 mg/dL. This study has been designed as double-blined clinical trial on 71 patients with type 2 diabetes and the patients randomly were divided to interventional and placebo groups. The patients on standard anti-diabetic therapy (metformin) treated with Olibanum gum resin (400 mg caps) and placebo tow times per day for 12 weeks, respectively. At the end of the twelfth week, the FBS, HbA1c, Insulin, total Cholesterol (Chol), LDL, Triglyceride (TG), HDL and other parameters were measured. The Olibanum gum resin lowered the FBS, HbA1c, Insulin, Chol, LDL and TG levels significantly (p < 0.001, p < 0.001, p <0.001, p = 0.003, p < 0.001 and p < 0.001, respectively) without any significant effects on the other blood lipid levels and liver/kidney function tests (p > 0.05) compared with the placebo at the endpoint. Moreover, this plant showed anti-oxidant effect and also no adverse effects were reported. The results suggest that Olibanum gum resin could be used as a safe anti-oxidant, anti-hyperglycemic and anti-hyperlipidemic agent for type 2 diabetic patients.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4177622PMC
October 2014

Serum Phospholipase A2-IIA, hs-CRP, and Lipids in Women With Subclinical Hypothyroidism.

Int J Endocrinol Metab 2014 Jul 10;12(3):e16967. Epub 2014 Jun 10.

Metabolic Diseases Research Center, Qazvin University of Medical Sciences, Qazvin, IR Iran.

Background: Subclinical hypothyroidism (SCH) is a metabolic disorder characterized by elevated TSH level but normal T4 level. Some previous studies suggest that SCH is associated with inflammation.

Objectives: The present study aimed to compare lipid serum levels in SCH patients and normal participants, also explore possible association between SCH and the two inflammatory markers hs-CRP and PLA2-IIA.

Patients And Methods: This study was performed on 77 women aged 20-45 (39 with SCH and 38 in the control group). TSH and T4 levels were measured by electrochemiluminescenceassay. Lipid profiles were analyzed using enzymatic-colorimetric methods. Hs-CRP and PLA2-IIA were determined using the ELISA method. IBM SPSS 19.0 was used for statistical analysis.

Results: Serum levels of TG, cholesterol, and LDL were higher in the SCH group than the control group. However, there was no significant difference between the two groups for HDL level. Likewise, no difference was observed for the serum level of hs-CRP. PLA2-IIA mean value was higher in the SCH group.

Conclusions: SCH is associated with increased level of PLA2-IIA, which is independent of BMI. The stronger association of SCH with PLA2-IIA than with hs-CRP indicates that PLA2-IIA is an inducer of inflammation while hs-CRP is not.
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http://dx.doi.org/10.5812/ijem.16967DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4166036PMC
July 2014

Influence of sleep disturbances on quality of life of Iranian menopausal women.

Psychiatry J 2013 5;2013:907068. Epub 2013 Nov 5.

Occupational Medicine, Qazvin University of Medical Sciences, Qazvin, Iran.

Background. Subjective sleep disturbances increase during menopause. Some problems commonly encountered during menopause, such as hot flushes and sweating at night, can cause women to have difficulty in sleeping. These complaints can influence quality of life of menopausal women. Methods. This cross-sectional study was performed on menopausal women attending health centers in Qazvin for periodic assessments. We measured excessive daytime sleepiness by Epworth sleepiness scale (ESS), obstructive sleep apnea (OSA) by the Berlin questionnaire, and insomnia by the insomnia severity index (ISI). We evaluate quality of life by the Menopause specific quality of life questionnaire (MENQOL). Results. A total of 380 menopausal women entered the study. Mean age of participated women was 57.6 ± 6.02. Mean duration of menopause was 6.3 ± 4.6. The frequency of severe and moderate insomnia was 8.4% (32) and 11.8% (45). Severe daytime sleepiness (ESS ≥ 10) was present in 27.9% (80) of the participants. Multivariate analytic results show that insomnia and daytime sleepiness have independent negative impact on each domain and total score of MENQOL questionnaire. Conclusion. According to our findings, EDS and insomnia are frequent in menopausal women. Both EDS and insomnia have significant quality of life impairment.
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http://dx.doi.org/10.1155/2013/907068DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3835748PMC
November 2013

Effect of treatment of vitamin D deficiency and insufficiency during pregnancy on fetal growth indices and maternal weight gain: a randomized clinical trial.

Eur J Obstet Gynecol Reprod Biol 2014 Jan 19;172:15-9. Epub 2013 Oct 19.

Qazvin University of Medical Sciences, Qazvin, Iran. Electronic address:

Objective: To determine whether treatment of low serum vitamin D in pregnant women improves fetal growth indices.

Study Design: In this open-label randomized clinical trial, 130 Iranian pregnant women (24-26 weeks of gestation) with vitamin D deficiency or insufficiency [25(OH)D <30ng/ml] were divided at random into an intervention group and a control group. The control group received 200mg calcium plus a multivitamin (containing vitamin D3 400U) each day, and the intervention group received 200mg calcium plus a multivitamin (containing vitamin D3 400U) each day, plus vitamin D3 (50,000U) each week for 8 weeks. At delivery, maternal and cord blood 25(OH)D levels, maternal weight gain, neonatal length, neonatal weight and neonatal head circumference were compared between two groups. Serum vitamin D was measured using enzyme-linked immunosorbent assay. A multivariate regression analysis was performed to examine the independent effect of maternal vitamin D level on fetal growth indices.

Results: Mean (±standard deviation) length (intervention group: 49±1.6cm; control group: 48.2±1.7cm; p=0.001), head circumference (intervention group: 35.9±0.7cm; control group: 35.3±1.0cm; p=0.001) and weight (intervention group: 3429±351.9g; control group: 3258.8±328.2g; p=0.01) were higher in the intervention group compared with the control group. Mean maternal weight gain was higher in the intervention group compared with the control group (13.3±2.4kg vs 11.7±2.7kg; p=0.006). Multivariate regression analysis for maternal weight gain, neonatal length, neonatal weight and neonatal head circumference showed an independent correlation with maternal vitamin D level.

Conclusion: Treatment of low serum vitamin D during pregnancy improves fetal growth indices and maternal weight gain.
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http://dx.doi.org/10.1016/j.ejogrb.2013.10.010DOI Listing
January 2014

Effects of additive therapy with spironolactone on albuminuria in diabetes mellitus: A pilot randomized clinical trial.

Caspian J Intern Med 2013 ;4(2):648-53

Metabolic Diseases Research Center, Qazvin University of Medical Sciences, Qazvin, Iran.

Background: Early diagnosis of albuminuria and the prevention of its progression to macroalbuminuria and diabetic nephropathy are crucial. Angiotensin converting enzyme inhibitors (ACEIs) and antagonists of angiotensin II receptors type I (ARBs) are currently used as first-line treatment for albuminuria in these patients. The present study was conducted to assess the efficacy of addition of spironolactone to ACEIs or ARB in the prevention of diabetic nephropathy.

Methods: Sixty patients were selected from the patients who referred to a Diabetes Clinic in this randomized clinical trial study. The control group received enalapril and the case group took additive therapy with spironolactone for 12 weeks. Blood pressure, concentrations of creatinine and albumin in the serum and urine, urinary albumin/creatinine ratio, serum potassium were determined for each patient in the beginning of and every 4-6 weeks until the end of the study. This clinical trial was registered in the Iranian Registry of Clinical Trials (www.irct.ir) with registration number ID: IRCT201105084849N2.

Results: There was statistically significant difference in albumin/creatinine ratio between the two groups (p<0.001). Albuminuria reduced more significantly in case group compared to control group. It was measured 66.6±26.8 mg/mmol and 45.7±19 mg/mmol in control and case groups, respectively. The patients did not develop any significant adverse effect including reduction in GFR, hyperkalemia, and hypotension.

Conclusion: Low to moderate doses of spironolactone can augment the effect of ACEIs in the prevention of diabetic nephropathy.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3755820PMC
September 2013

Effect of low glycemic load diet with and without wheat bran on glucose control in gestational diabetes mellitus: A randomized trial.

Indian J Endocrinol Metab 2013 Jul;17(4):689-92

Qazvin Research Center for Social Determinants of Health, Qazvin University of Medical Sciences, Qazvin, Iran.

Background: A low-glycemic index diet is effective in blood glucose control of diabetic subjects, reduces insulin requirement in women with gestation diabetes mellitus (GDM) and improves pregnancy outcomes when used from beginning of the second trimester. However there are limited reports to examine the effect of low glycemic load (LGL) diet and fiber on blood glucose control and insulin requirement of women with GDM. Therefore, the aim of this study was to examine the effect of low glycemic load diet with and without fiber on reducing the number of women with GDM requiring insulin.

Materials And Methods: All GDM women (n = 31) were randomly allocated to consume either a LGL diet with Fiber or LGL diet.

Results: We found that 7 (38.9%) of 18 women with GDM in Fiber group and 10 (76.9%) in "Without Fiber" group required insulin treatment.

Conclusion: The LGL diet with added fiber for women with GDM dramatically reduced the number needing for insulin treatment.
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http://dx.doi.org/10.4103/2230-8210.113762DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3743371PMC
July 2013

Urinary total protein as the predictor of albuminuria in diabetic patients.

Int J Endocrinol Metab 2012 30;10(3):523-6. Epub 2012 Jun 30.

Metabolic Disease Research Center, Qazvin University of Medical Sciences, Qazvin, IR Iran.

Background: In order to detect nephropathy, measurement of total (24 hrs) urinary albumin or albumin/creatinin ratio in random urine samples is being recommended. But methods of albumin measurement are not available in all laboratories and also cost about 6 times more than that of urinary total protein measurement.

Objectives: This Study was performed to determine appropriate cut off point in 24 hours urine total protein to diagnose micro- and macroalbuminuria in patients with diabetes mellitus.

Patients And Methods: In this study, 204 patients with diabetes mellitus type I and II were selected. In collected 24 hours urine from patients, protein and albumin were measured by using Pyrogallol and Immunoturbidimetry methods, respectively.

Results: Normoalbuminuri (albumin < 30 mg/24 hrs urine), microalbuminuri (albumin = 30-300 mg/24 hrs urine), and macroalbuminuri (albumin > 300 mg/24 hrs urine) were detected in 130, 51, and 23 patients, respectively. In 24 hrs urine collections, amounts of protein and albumin were compared to calculate cut off point of exerted protein for nephropathy diagnosis. cut off point of 73 mg/day for urinary total protein had appropriate sensitivity (94.5 %, CI = 91.4 % -97.6 %) and specificity (77.9 %, CI = 72.8 % -82.9 %) for microalbuminuria, while cut off point of 514 mg/day (sensitivity 95.7 %; specificity 98.9 %) was detected for diagnosis macroalbuminuria. Urine protein exertion of 150 mg/day that is currently considered as a normal value in most laboratory kits had a sensitivity of 73.1 % by which 30 % of microalbuminuric cases remained undiagnosed.

Conclusions: Urinary total protein cut-off points of 73 mg/day and 514 mg/day were diagnostic for micro- and macroalbuminuria, respectively.
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http://dx.doi.org/10.5812/ijem.4236DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3693628PMC
July 2013

Effect of vitamin D administration in vitamin D-deficient pregnant women on maternal and neonatal serum calcium and vitamin D concentrations: a randomised clinical trial.

Br J Nutr 2013 Nov 29;110(9):1611-6. Epub 2013 Apr 29.

Metabolic Diseases Research Center, Qazvin University of Medical Science, Qazvin, Iran.

There are several studies in which a correlation between maternal vitamin D deficiency and serum mineral disorders in the mother and the newborn has been reported. The present randomised clinical trial was designed to investigate the effect of vitamin D administration on maternal and fetal Ca and vitamin D status. The trial was carried out on 160 pregnant women. Vitamin D-deficient (25-hydroxyvitamin D (25(OH)D) < 30 ng/ml) pregnant women were recruited at 26-28 weeks of pregnancy. In the control group, a multivitamin supplement containing 400 IU vitamin D3/d was given. Patients in the treatment group were treated with 50 000 IU vitamin D3 weekly for a total duration of 8 weeks. At delivery, maternal and fetal Ca and 25(OH)D levels in both groups were compared. In total, 81 % of pregnant women were vitamin D deficient. At the time of delivery, Ca and vitamin D levels were higher in the treatment group compared with the control group (92 (SD 3) v. 85 (SD 4) mg/l, respectively, P= 0·001 for serum Ca; 47·8 (SD 11·1) v. 15·9 (SD 6·6) ng/ml, respectively, P< 0·001 for vitamin D). At the time of delivery, 32·7 % of women in the control group had hypocalcaemia, while no hypocalcaemic case was detected in the vitamin D-treated group. Mean neonatal serum 25(OH)D was higher in the treatment group compared with the control group (27·7 (SD 5·2) v.10·9 (SD 4·4) ng/ml, respectively, P< 0·01). The neonatal Ca level in the treatment group was significantly higher than that of the control group (99 (SD 3) v. 91 (SD 3) mg/l, respectively, P< 0·001). The administration of vitamin D to pregnant women with vitamin D deficiency improves both maternal and neonatal Ca levels.
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http://dx.doi.org/10.1017/S0007114513001244DOI Listing
November 2013

A comparison of health-related quality of life among normal-weight, overweight and obese adults in Qazvin metabolic diseases study (QMDS), Iran.

Glob J Health Sci 2013 Feb 26;5(3):156-62. Epub 2013 Feb 26.

Metabolic Diseases Research Center, Qazvin University of Medical Sciences, Qazvin, Iran.

Background: Obesity is a public health problem that has raised concern worldwide. Numerous epidemiological studies have been showed the relationship between obesity, abdominal fatness and risk of a wide range of illnesses (i.e. diabetes). Obese people experience health-related quality-of-life (HRQL) impairments. The purpose of this study was to evaluate the effect of BMI on Quality of Life, among Normal-Weight, Overweight and Obese adults in Qazvin, Iran.

Methods: This Cross-Sectional study was conducted on 1103 subjects (aged 20-78 years old) from September 2010 to April 2011 in Qazvin, Iran. The study subjects were selected by multistage cluster random sampling method from residents of mindoodar district of Qazvin. Obesity was defined based on Body Mass Index and SF-36 questionnaire was used as measurement instrument for quality of life. Data were analyzed by Chi-square test, ANOVA and MANOVA.

Results: A total of 527 men and 576 women were entered the study. Mean BMI was 25.97 ±4.5 Kg/m2. The scores of 6 domains were significantly different between 3 groups of BMI. The differences of physical component summary (PCS) and mental component summary (MCS) scores were also significant between normal weight, overweight and obese subjects (p<0.001 and p<0.025, respectively).

Conclusion: This study underlines the importance of HRQL in overweight and obese individuals. These results suggest that more attention to the obesity and overweight is needed in Iranian population.
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http://dx.doi.org/10.5539/gjhs.v5n3p156DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4776823PMC
February 2013

Association between metabolic syndrome and premicroalbuminuria among Iranian women with Polycystic Ovary Syndrome: a case control study.

Glob J Health Sci 2012 Nov 30;5(1):187-92. Epub 2012 Nov 30.

Department of Community Medicine, Qazvin University of Medical Sciences, Qazvin, Iran.

Objective: The aim of this study was to assess the association between premicroalbuminuria and metabolic syndrome in women with Polycystic Ovary Syndrome (PCOS).

Methods: In this case - control study, we analyzed the medical records of 78 women (mean age ±SD was 27.2± 2.5 years) with PCOS and 63 controls (mean age ±SD was 26.9±2.4 years) from an endocrinology outpatient center of Buali university hospital Qazvin city in Iran during 2008 to 2010. Anthropometric characteristics, Albumin/Creatinine Ratio (ACR), Lipid profile, Liver enzyme concentration and occurrence of metabolic syndrome were compared between the two groups. Premicroalbuminuria was defined as ACR>7mg/g.

Results: Premicroalbuminuria was found in 53.8% of PCOS and 33.3% of control group (p value=0.015). Patients with PCOS and premicroalbuminuria had higher serum levels of fasting insulin and glucose, blood pressure and more waist circumference compared to PCOS patients who had ACR<7mg/g. Fifty percent of patients with PCOS and ACR>7mg/g fulfilled criteria of metabolic syndrome; whereas no case of metabolic syndrome was found in PCOS patients without premicroalbuminuria.

Conclusions: Premicroalbuminuria is more prevalent in patients with PCOS compared to normal individuals. Metabolic syndrome is more frequently seen in patients with PCOS and premicroalbuminuria against patients with ACR<7mg/g.
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http://dx.doi.org/10.5539/gjhs.v5n1p187DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4776989PMC
November 2012

Nutritional status assessment of Minodar residence in Qazvin city, Iran: vitamin D deficiency in sunshine country, a public health issue.

Glob J Health Sci 2012 Nov 20;5(1):174-9. Epub 2012 Nov 20.

Qazvin University of Medical Sciences, Qazvin, Iran.

Introduction: Nutrition has main effect on health or disease and results of nutrition assessment can be used in health planning of communities. Therefore we aimed to conduct the nutrition assessment especially vitamin D statue of an urban region in Qazvin city.

Methods: In a cross sectional study in year 2011, subjects who were randomly selected from residents of aged ≥ 20 years old in Minodar, an urban region of Qazvin city participated in this study. A 3-days food diary questionnaire was used to collect food consumption data and weight and height of subjects were measured. The food intake was analysis using "Nutrition 4, Diet analysis, Module version 3.5.2".

Results: The participants included 930 subjects (434 M and 496 F) having Mean BMI = 26 ± 4.4 kg/m2 and 60% of subjects were either overweight or obese. Daily energy intake of 50% of subjects was more than 2500 (13.6% from proteins, 55.6% from carbohydrate and 30.5% from fat sources). The daily cholesterol intake among 50-75% of population was more than daily recommended of 300 mg. The mean iron and zinc intakes were 17±5.6 and 12±4.5 mg/day and the intakes were highest in aged group of 20-29, while reduced in older groups. Vitamin A deficiency was observed in studied population and 75% of them were receiving less than daily recommended allowance of 800 μg/day, 25% of total studied population was receiving less than 400 μg/day. Vitamin D ingestion among 90-95% of participants was less than minimum daily recommended amount of 10 μg/day and calcium intake in 50-75% of studied population was less than recommended daily allowance of 800 mg/day. High amount of florid and caffeine ingestion from black tea was observed among population and 75% of population had florid intake of 10000 mμ/day.

Conclusion: In general, majority of the population of region had higher amount intake of fat, cholesterol, low intake of calcium and vitamin D.
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http://dx.doi.org/10.5539/gjhs.v5n1p174DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4776967PMC
November 2012

Association between Uric Acid and Metabolic Syndrome in Qazvin Metabolic Diseases Study (QMDS), Iran.

Glob J Health Sci 2012 Nov 14;5(1):155-65. Epub 2012 Nov 14.

Metabolic Diseases Research Center, Qazvin University of Medical Science, Qazvin, Iran.

Background: The prevalence of Metabolic Syndrome (MS) has been increasing worldwide. Although Uric Acid (UA) Levels are often increased in subjects with MS, it is still unclear whether uric acid plays a causal role for MS or is a marker. The purpose of this was to examine the association between UA and the MS in Qazvin, Iran.

Methods: 529 men and 578 women aged 20 - 78 years attended in cross sectional study from September 2010 to April 2011 in Qazvin, Iran. The criteria proposed by new joint Interim societies (JIS) were applied for diagnosis of MS. Hyperuricemia was defined as UA ≥ 7 mg/dL in men and UA ≥ 6 mg/dL in women. Logistic regression analysis was performed to evaluate the relationship between UA quartiles and MS.

Results: The prevalence of MS was found to be 39.3%. Prevalence of hyperuricemia was 8.4% in males and 4.1% in females. (P= 0.004) Mean UA level was higher in males than in females. (P<0.001) UA levels increased significantly with an increasing number of MS components in both genders. Prevalence of MS increased across UA quartiles in females; however the increasing trend began from second quartile in males. Using the lowest quartile of UA level as a reference, there were no significant association between UA quartile groups and MS.

Conclusion: This study showed that UA levels are not an appropriate predictor of MS in Iranian population. More longitudinal studies are necessary to confirm the role of UA in MS occurrence.
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http://dx.doi.org/10.5539/gjhs.v5n1p155DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4776955PMC
November 2012

Effect of low-glycemic load diet on changes in cardiovascular risk factors in poorly controlled diabetic patients.

Indian J Endocrinol Metab 2012 Nov;16(6):991-5

Qazvin Research Center for Social Determinants of Health Science (QRC SDH), Qazvin University of Medical Sciences, Qazvin, Iran.

Background: One dietary strategy aimed at improving both diabetes control and control of cardiovascular risk factors is the use of low glycemic index diets. These diets have been reported to be beneficial in controlling diabetes, and also increase high density lipoprotein cholesterol (HDL-C), lower serum triglyceride, and reduce glycated protein.

Aim: Therefore, we aimed to investigate the effect of a low glycemic index-low glycemic load (GL = 67-77) diet on lipids and blood glucose of poorly controlled diabetic patients.

Materials And Methods: In an intervention study, 100 poorly controlled diabetic patients (age 52.8 ± 4.5 years) who were taking insulin or on oral medication underwent administration of low GL diet (GL = 67-77; energy = 1800-2200 kcal, total fat = 36%, fat derived from olive oil and nuts 15%, carbohydrate = 41%, protein = 22%) for 10 weeks. Patients were recommended to follow their regular lifestyle. Total cholesterol, low density lipoprotein (LDL), HDL, triglyceride, glycated hemoglobin (HbA1c), weight, and body mass index (BMI) were measured before and 10 weeks after the intervention.

Results: Before intervention, initial blood cholesterol and triglyceride concentrations were 205.9 ± 21.6 and 181.5 ± 22.2, respectively, and were reduced to 182.6 ± 18.2 and 161.6 ± 16.7, respectively, after 10 weeks intervention (P < 0.001). LDL reduced and HDL increased significantly. The HbA1c percentage reduced by 12% (from 8.85 ± 0.22% to 7.81 ± 0.27%) (P < 0.001), and also their weight significantly reduced from 74.0 ± 5 kg to 70.7 ± 4.6 kg (P < 0.001).

Conclusion: This study demonstrated that low GL diet having lower carbohydrate amount and higher fat content is an appropriate strategy in blood lipid and glucose response control of poorly controlled diabetic patients.
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http://dx.doi.org/10.4103/2230-8210.103010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3510974PMC
November 2012

Effects of metformin, pioglitazone, and silymarin treatment on non-alcoholic Fatty liver disease: a randomized controlled pilot study.

Hepat Mon 2012 Aug 3;12(8):e6099. Epub 2012 Aug 3.

Metabolic Disease Research Center, Qazvin University of Medical Science, Qazvin, IR Iran.

Background: Nonalcoholic fatty liver disease (NAFLD) is one of the most common reasons of enzyme increase in liver. In About 10 percent of patients with NAFLD, the disease progresses toward Non Alcoholic Steatohepatitis (NASH) and about one third of them may progress toward cirrhosis, liver dysfunction, and even hepatocellular carcinoma.

Objectives: According to high prevalence of NAFLD and the fact that there is no consensus on treatment of this disease, the aim of this study was to assess the effects of metformin, pioglitazone, and silymarin on treatment of NAFLD.

Patients And Methods: Sixty six patients with NAFLD who were presented in the Endocrinology and Metabolism clinic of Boo'ali Hospital, Qazvin, Iran, were assigned randomly into three groups (n = 22). First group was treated by pioglitazone 15 mg/d, second group by metformin 500 mg/d, and third group by silymarin 140 mg/d. All patients underwent clinical and biochemical evaluations including weight, fasting blood sugar (FBS), lipid profiles, body mass index (BMI), aspartate aminotransferase (AST ), alanine aminotransferase (ALT), and serum insulin levels in pre- and post-intervention after eight-week follow up.

Results: Before the treatment there was no significant difference between three groups with respect to average age, BMI and gender, FBS, lipid profile, AST, ALT, serum insulin level, and Homeostasis Model Assessment (HOMA) index for insulin resistance. After the intervention, a significant reduction was observed in average amount of FBS, lipid profile, ALT, AST, serum insulin level and HOMA index in three groups (P < 0.01). The most reduction in average FBS, TG, serum insulin level, and HOMA index was observed in pioglitazone group, the most reduction in average amount of cholesterol was seen in metformin group, and the most decrease in average amount of AST and ALT occurred in silymarin group.

Conclusions: These results suggest that all drugs are beneficial in improving biochemical indices in patients with NAFLD. Changes in AST and ALT in silymarin group were demonstrated more than that in other groups and the average difference between changes was significant between silymarin and metformin groups.
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http://dx.doi.org/10.5812/hepatmon.6099DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3475019PMC
August 2012

Effect of low glycemic load diet on glycated hemoglobin (HbA1c) in poorly-controlled diabetes patients.

Glob J Health Sci 2011 Dec 29;4(1):211-6. Epub 2011 Dec 29.

Metabolic Disease Research Center, Qazvin University of Medical Science, Qazvin, Iran.

Different carbohydrate diets have been administrated to diabetic patients to evaluate the glycemic response, while Poor-controlled diabetes is increasing world wide. To investigate the role of an alternative carbohydrate diet on glycemic control, we explored the effect of a low glycemic load (Low GL)-high fat diet on glycemic response and also glycated hemoglobin (HbA1c) of poor-controlled diabetes patients. Hundred poorly-controlled diabetes patients, HbA1c > 8, age 52.8 ± 4.5 y, were administrated a low GL diet , GL = 67 (Energy 1800 kcal; total fat 36%; fat derived from olive oil and nuts 15%; carbohydrate 42%; protein 22%) for 10 weeks. Patients did their routine life style program during intervention. Fasting blood glucose and HbA1c before and after intervention with significant reduction were: 169 ± 17, 141 ± 12; 8.85% (73 mmol/mol) ± 0.22%, and 7.81% (62 mmol/mol) ± 0.27%; respectively (P < 0.001). Mean fasting blood glucose reduced by 28.1 ± 12.5 and HbA1c by 1.1% (11 mmol/mol) ± 0.3% (P=0.001). There was positive moderate correlation between HbA1c concentration before intervention and FBS reduction after intervention (P < 0.001, at 0.01 level, R =0.52), and strong positive correlation between FBS before intervention and FBS reduction (P < 0.001, at 0.01 level, R = 0.70). This study demonstrated that our alternative low glycemic load diet can be effective in glycemic control.
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http://dx.doi.org/10.5539/gjhs.v4n1p211DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4777031PMC
December 2011

Effect of an integrated case-based nutrition curriculum on medical education at Qazvin University of Medical Sciences, Iran.

Glob J Health Sci 2011 Dec 29;4(1):112-7. Epub 2011 Dec 29.

Qazvin University of Medical Science, Qazvin, Iran.

Introduction: Nutrition education is identified as an important part of medical education by organizations. Qazvin University of Medical Sciences, school of medicine (QUMS SOM), has a required basic nutrition course of 36 hr in second year of medical school, but education experts reports show that the course does not provide required therapeutic skills for graduate student.

Method: We decided to organize an 8-hr diet therapy work shop in order to develop a patient experience clinical based case study teaching to enhance clinical skills at QUMS SOM.

Results: Students' perception score about adequacy of nutrition instruction increased from 20% (at baseline) to 70% (after intervention). The mean nutrition knowledge score of total students in clinical nutrition were different between before and one month after integration (8.3±2.5, 13.4±3.2, P < 0.001). And two groups of participants including staggers and interns had similar nutritional knowledge score at pre-test (7.9±2.6 and 8.9±2.3 respectively).

Conclusion: Implemented nutrition curriculum at QUMS was appropriate method to enhance student's perception about nutrition integration and to increase and translate the knowledge to clinical practice.
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http://dx.doi.org/10.5539/gjhs.v4n1p112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4777021PMC
December 2011

Effects of folic acid plus levothyroxine on serum homocysteine level in hypothyroidism.

Caspian J Intern Med 2012 ;3(2):417-20

Metabolic Diseases Research Center, Qazvin University of Medical Sciences, Qazvin, Iran.

Background: Rise in serum homocysteine level may be associated with higher prevalence of cardiovascular diseases in hypothyroidism. Levothyroxine can partly diminish serum homocysteine level. Folic acid participates in homocysteine metabolic cycle in the human body. The effect of concomitant administration of folic acid and levothyroxine on serum homocysteine level was evaluated in the present study.

Methods: Sixty patients with hypothyroidism participated in this double-blinded clinical trial study. They were divided into two equal groups; Group A received oral levothyroxine 50-100 µg daily. Group B took oral folic acid 1 mg on a daily basis in addition to levothyroxine with similar schedule to group A. The patients were followed up for two months. The serum homocysteine levels of these two groups were measured before and after the study. This study was registered in Iranian Registry of clinical trial (IRCT number: 201112077723N1).

Results: Mean serum homocysteine level fell from 11.5±4.2 to 9.9±3.5 µmol/lit and from 11.2±3.1 to 6.9±1.9 µmol/lit in group A and B, respectively (p<0.001). The mean reduction in serum homocysteine levels were 1.6±1.2 µmol/lit and 4.3±1.4 µmol/lit in group A and B, respectively (p<0.001).

Conclusion: Levothyroxine can decrease serum homocysteine level partly; still its combination with folic acid empowers the effect. Combination therapy declines serum homocysteine level more successfully.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3861905PMC
December 2013

Effect of metformin and pioglitazone treatment on cardiovascular risk profile in polycystic ovary syndrome.

Acta Med Indones 2012 Jan;44(1):16-22

Department of Endocrinology, Metabolic Disease Research Center, Qazvin University of Medical Science, Qazvin, Iran.

Aim: to compare the effectiveness of metformin and pioglitazone in ameliorating insulin resistance and cardiovascular risk factors in women with polycystic ovary syndrome (PCOS).

Methods: this study was a randomized clinical trial to compare treatment with metformin and pioglitozone. Fifty two women with PCOS aged 20-45 years were randomly allocated to one of the two treatment groups. All patients underwent clinical and biochemical evaluation and analyses involving these measures which consisted of repeated measures MANOVA using the pre- and post-intervention fasting blood sugar (FBS), lipid profiles, body mass index (BMI), serum insulin in two groups.

Results: weight and BMI were significantly decreased in metformin group but not in case of pioglitazone. FBS, serum triglycerides, total cholesterol were all reduced significantly by both metfomin and pioglitazone. Insulin resistance measured by homeostasis model assessment (HOMA) method was significantly decreased in both treatment groups (P<0.05). There were no significant differences between treatments in most of variables except BMI.

Conclusion: these results suggest pioglitazone is as effective as metformin in improving insulin sensitivity and some cardiovascular risk biomarkers but it has no significant effect on reducing BMI and body weight.
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January 2012

The efficacy of licorice root extract in decreasing transaminase activities in non-alcoholic fatty liver disease: a randomized controlled clinical trial.

Phytother Res 2012 Sep 6;26(9):1381-4. Epub 2012 Feb 6.

Qazvin University of Medical Sciences, Qazvin, Iran.

This study was performed to investigate the effects of licorice on non-alcoholic fatty liver disease (NAFLD). In this double blind randomized clinical trial, 66 patients were divided into case and control groups. All patients had elevated liver enzymes and had increased liver echogenicity (lipid accumulation) on sonography. The case group was treated with one capsule containing 2 g aqueous licorice root extract per day for 2 months while the control group was treated in the same manner with a placebo. Weight, body mass index (BMI) and liver transaminase levels were measured for each patient before and after the study. In the case group, the mean alanine aminotransferase (ALT) level decreased from 64.09 to 51.27 IU/mL and the aspartate aminotransferase (AST) level decreased from 58.18 to 49.45 IU/mL, which were statistically significant (p < 0.001 and p < 0.001). But in the control group, a drop in the ALT and AST levels was not statistically significant. The BMI difference before and after the study was not statistically significant in both groups. Despite the significant drop in liver enzymes following administration of licorice root extract, it is recommended that further studies that include histological examination are necessary.
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http://dx.doi.org/10.1002/ptr.3728DOI Listing
September 2012