Publications by authors named "Amir Larki-Harchegani"

13 Publications

  • Page 1 of 1

Acute Mesenteric Ischemia in a Patient with COVID-19: A Case Report.

Arch Iran Med 2020 09 1;23(9):639-643. Epub 2020 Sep 1.

Department of Pharmacology and Toxicology, School of Pharmacy, Hamadan University of Medical Sciences, Hamadan, Iran.

The severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) presents clinical manifestations similar to the influenza, severe acute respiratory syndrome (SARS-CoV), and Middle East respiratory syndrome (MERS-CoV). However, in the course of the coronavirus disease 2019 (COVID-19), various pathological complications of high clinical significance have remained unknown. Impaired blood supply to the visceral vascular system can cause serious life-threatening acute damage. We report a case of extensive acute mesenteric ischemia associated with SARS-CoV-2 infection confirmed in a patient hospitalized in Amin Hospital - a COVID-19 referral center in Isfahan University of Medical Sciences, Isfahan, Iran. This case highlights the importance of paying attention to serious and less common or less known clinical manifestations other than fever, dry cough, dyspnea, and myalgia.
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http://dx.doi.org/10.34172/aim.2020.77DOI Listing
September 2020

Pharmacy students' level of financial literacy and its differences among students with various career intentions.

Curr Pharm Teach Learn 2020 06 26;12(6):671-679. Epub 2019 Nov 26.

Hamadan University of Medical Sciences School of Pharmacy, Shahid Fahmideh Boulevard, Hamadan, Iran.

Background: Many pharmacy students will work at managerial positions after graduation, so policymakers' awareness from their level of financial literacy and intentions regarding their future career field and path might be helpful to identify existing gaps and needed interventions. The purpose of this study was to assess the level of financial literacy among pharmacy students and their intentions regarding career path and field.

Methods: Data were gathered in early 2018 using a questionnaire which consisted of three parts: questions on financial literacy, career intentions, and participants' characteristics. Data analysis included descriptive analysis, comparison of the level of financial literacy and career intention among different demographic groups, as well as the comparison of the level of financial literacy among students preferring various career fields and paths.

Results: A total of 173 usable questionnaires were gathered. Significant differences were observed in terms of the level of financial literacy between various groups of students' personal income, term of education, and history of receiving finance-related information from people around them. Students showed more weakness in responding to questions related to investment. It was also revealed that students with higher scores in financial literacy gave priority to fast entrance to the job market compared to other suggested career paths.

Conclusions: Although improvement in all aspects of financial literacy seem required for the studied population, more weakness was observed in terms of investment questions. Community pharmacy and rapid entrance to the work market were the preferred career field and path, respectively.
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http://dx.doi.org/10.1016/j.cptl.2019.10.008DOI Listing
June 2020

The heel amelanotic melanoma, a rare subtype of skin cancer misdiagnosed as foot ulcer: A case report.

Int Wound J 2020 Jun 11;17(3):819-822. Epub 2020 Mar 11.

Department of Surgery, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.

Amelanotic melanoma (AM) of the heel is a very rare subtype of malignant melanoma in which the tumour cells, unlike other types of melanoma, are characterised by little or no melanin pigmentation. AM resembles many benign dermatological complications that often lead to late diagnosis of lesions, poor prognosis, and occasionally misdiagnosis at an early stage of the disease. We report a case of a 73-year-old man with a heel ulcer who was admitted to Al-Zahra Hospital (Isfahan, Iran). Chronic osteomyelitis was considered the primary diagnosis, and several courses of antibiotics were prescribed for the patient. The ulcer failed to improve after 9 months' of therapy, and because of an increase in the size of the ulcer and the growth of two tumours in the right heel, a biopsy of the lesion was conducted. The pathology report confirmed invasive AM. The present report emphasises the necessity to biopsy all skin lesions, even with low clinical significance, to avoid wrong subsequent treatments, prevent a delay in diagnosis, reduce misdiagnosis, and improve the survival rate of patients.
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http://dx.doi.org/10.1111/iwj.13338DOI Listing
June 2020

A rare enzymatic defect, true isolated 17,20-lyase deficiency leading to endocrine disorders and infertility: case report.

Gynecol Endocrinol 2020 Apr 6;36(4):297-302. Epub 2019 Nov 6.

Department of Clinical Pharmacy and Pharmacy Practice, School of Pharmacy, Isfahan University of Medical Sciences, Isfahan, Iran.

The cytochrome P450 17A1 catalyzes the formation of 17-hydroxysteroids and 17-ketosteroid. Most defects in CYP17A1 impair both enzymatic activities and cause a combined 17α-hydroxylase/17,20-lyase deficiency, which impairs hormone production (cortisol and sex steroids), sexual development, and puberty. Isolated 17,20-lyase deficiency is usually defined by evidently normal activity of 17α-hydroxylase with a dramatic decline of 17,20-lyase activity or complete inactivity. The changes in enzyme activity lead to a lack in the production of sex steroids with normal levels of glucocorticoid and mineralocorticoid hormones. A 24-years-old married woman, as a product of a consanguineous marriage, presented with infertility and a background marked by primary amenorrhea. Laboratory data showed low normal serum cortisol levels and low levels of 17-hydroxyprogesterone. Also, her adrenal androgens were low but estradiol was normal. The chromosomal investigation uncovered a male karyotype of 46, XY. These clinical and laboratory evidence confirm the determination of an isolated 17,20-lyase deficiency in a genotypic male.
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http://dx.doi.org/10.1080/09513590.2019.1683819DOI Listing
April 2020

The role of ghrelin and tumor necrosis factor alpha in diazinon-induced dyslipidemia: insights into energy balance regulation.

Pestic Biochem Physiol 2019 Jun 19;157:138-142. Epub 2019 Mar 19.

Medicinal Plants and Natural Products Research Center, Hamadan University of Medical Sciences, Hamadan, Iran; Department of Pharmacology and Toxicology, School of Pharmacy, Hamadan University of Medical Sciences, Hamadan, Iran.

The evidence shows that organophosphate compounds (OPCs), as toxic agents that stimulate the cholinergic system, can increase the incidence of metabolic disorders such as dyslipidemia. In the present study, we focused on the role of tumor necrosis factor alpha (TNF-α) and serum leptin and ghrelin in Diazinon (DZN)-induced dyslipidemia. The rats were randomly divided into five groups comprising eight animals, and all were treated via oral gavage for 28 consecutive days as follows: group one received only corn oil daily, while groups two through five received different doses of DZN dissolved in corn oil equal to 1/40, 1/20, 1/10 and 1/5 of the LD50 daily, respectively. The alteration of the serum lipid profile, such as triglycerides, high-density lipoprotein (HDL) and very-low-density lipoprotein (VLDL), was confirmed the occurrence of dyslipidemia in the range of doses 1/20-1/5 LD50 of DZN. Although no changes were found in the serum leptin levels, a significant increase was observed in the size of adipocytes, as well as in the TNF-α and ghrelin serum levels, and in the accumulation of epididymal fat, especially at a dose of 1/5 LD50 of DZN. It seems that interactions among the inflammatory reaction, cholinergic pathways and ghrelin secretion may be effective causes of DZN-induced dyslipidemia.
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http://dx.doi.org/10.1016/j.pestbp.2019.03.013DOI Listing
June 2019

Protective effects of Allium hirtifolium Boiss extract on cadmium-induced renal failure in rats.

Environ Sci Pollut Res Int 2019 Jun 10;26(18):18886-18892. Epub 2019 May 10.

Medicinal Plants and Natural Products Research Center, Hamadan University of Medical Sciences, Hamadan, Iran.

Cadmium (Cd), as a toxic metal, can accumulate in kidneys and induce renal failure. This study was undertaken to evaluate the protective effects of Allium hirtifolium Boiss bulbs against Cd-induced renal failure in rats. Thirty-six rats were divided into 6 groups: group 1, 2, and 3 received vehicle, Cd (100 mg/L/day by drinking water), and AhB extract (200 mg/kg/day; orally), respectively. Groups 4, 5, and 6 were Cd groups which treated AhB extract (50, 100, and 200 mg/kg/day, respectively). After 2 weeks, renal function and oxidative stress markers were determined by using colorimetric methods. Our findings showed that Cd caused a significant increase in creatinine (Cr; p<0.05), uric acid (p<0.01), BUN (p<0.05), serum levels, lipid peroxidation (LPO; p<0.01), and nitric oxide (NO; p<0.01); the depletion of the total antioxidant capacity (TAC; p<0.01) and total thiol molecules (TTM; p<0.001); and structural alterations in the renal tissue. Following AhB extract administration, a remarkable improvement was observed in the functional and oxidative stress markers of renal tissue.This study suggests that AhB may prevent progression of Cd-induced renal failure via improvement of oxidative/antioxidant balance in renal tissue.
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http://dx.doi.org/10.1007/s11356-019-04656-7DOI Listing
June 2019

Thymoquinone attenuates hepatotoxicity and oxidative damage caused by diazinon: an study.

Res Pharm Sci 2018 Dec;13(6):500-508

Department of Pathology, School of Medicine, and Clinical education Research center, Shiraz University of Medical Sciences, Shiraz, I.R. Iran.

Thymoquinone (TQ) is the main active constituent of seeds. The objective of this study was to explore the protective effects of TQ on diazinon (DZN)-induced liver toxicity in the mouse model. The animals were divided into five groups of 6 each and treated intraperitoneally. Group 1 received the vehicle, group 2 was given 16 mg/kg DZN, group 3 received 5 mg/kg TQ, and groups 4 and 5 were treated with 1.25 and 5 mg/kg of TQ as well as 16 mg/kg DZN, respectively. Finally, butyrylcholinesterase (BChE), alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase (ALP) serum activity as well as nitric oxide (NO), lipid peroxidation (LPO), total antioxidant capacity (TAC), total thiol molecule (TTM), and histopathological experiments were evaluated in the liver samples. Our findings showed that DZN caused a significant increase in ALT ( < 0.01), AST ( < 0.001), ALP ( < 0.001) serum levels, LPO ( < 0.001) and NO ( < 0.001), the depletion of the TAC ( < 0.05) and TTM ( < 0.001), and structural changes in the liver tissue. Following TQ administration, a significant improvement was observed in the oxidative stress biomarkers in the liver tissue. In addition, our biochemical findings were correlated well to the histopathological examinations. In conclusion, the data from this study indicate that the administration of TQ may prevent liver damage by preventing free radical formation in animals exposed to DZN.
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http://dx.doi.org/10.4103/1735-5362.245962DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6288994PMC
December 2018

Protective effect of amlodipine on diazinon-induced changes on oxidative/antioxidant balance in rat hippocampus.

Res Pharm Sci 2018 Aug;13(4):368-376

Department of Medicinal Chemistry, School of Pharmacy, Hamadan University of Medical Sciences, Hamadan, I.R. Iran.

Oxidative stress (OS) is a main mechanism in organophosphorus poisoning. The effects of calcium channel blockers have been confirmed in decreasing of oxidative stress. In the current study, the effects of amlodipine (AM), as a calcium channel blocker, were evaluated on oxidative damages induced by diazinon (DZN) in hippocampus tissue of Wistar rats. Forty-two rats were divided into six groups and treated intraperitoneally for two weeks. Group 1 served as control received vehicle, group 2 was treated with 9 mg/kg of AM, group 3 (positive control) received DZN (32 mg/kg), Groups 4, 5, and 6 were treated with 3, 6, and 9 mg/kg of AM adjunct with DZN (32 mg/kg), respectively. After 14 days, all the animals were sacrificed under anesthesia and hippocampus tissue and blood samples were collected for biochemical analysis and histopathology experiments. The results showed that DZN caused significant increase in lipid peroxidation ( < 0.001), nitric oxide ( < 0.001) and lactate dehydrogenase ( < 0.001) levels, depletion of total antioxidant capacity ( < 0.01), and structural changes in hippocampus tissues. Following AM administration, a significant improvement was observed in oxidative biomarkers in hippocampus tissues. Additionally, our biochemical findings were related well with histopathological examinations. In conclusion, the data of this study indicated that AM administration may prevent oxidative damages via improving of energy production and preventing of free radical formation in DZN-exposed animals.
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http://dx.doi.org/10.4103/1735-5362.235164DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6040164PMC
August 2018

Wound healing property of milk in full thickness wound model of rabbit.

Int J Surg 2018 Jun 22;54(Pt A):133-140. Epub 2018 Apr 22.

Department of Pharmacology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran. Electronic address:

Objective: Wound healing consists of several continuous phases in which various cells and chemical intermediates are involved. Milk as a rich source of nutritional elements has proved to have potential benefits for treatment of various diseases. The present study was designed to investigate the healing effect of low-fat cow's milk on an open skin wound model in the rabbit.

Methods: The 2%, 5%, and 10% (w/w) ointments of lyophilized powder of low-fat milk were prepared in the eucerin base and were applied twice daily in the treatment groups. Phenytoin 1% ointment was used as a standard control. The healing effect of the milk ointment (MO) was evaluated through the measurement of wound surface area, the extent of tissue tension, and the content of hydroxyproline. Histological evaluation of skin tissue specimens was also performed using hematoxylin and eosin staining.

Results: The results showed that the healing rate in the treatment group was significantly higher than that of untreated group and eucerin group (p < 0.01). The best healing effect was seen in 5% milk ointment with the shortest healing time (15 days) and the highest tissue tension in comparison to other groups. Although the tissue hydroxyproline content in this group was slightly lower than that of the phenytoin group, this difference was not significant. Histologic, findings indicated increased collagen fibers, increased fibroblasts and an evident decrease in inflammatory cells in that group.

Conclusion: It can, therefore, be concluded that low-fat cow's milk has significant beneficial effects on skin wound healing. Therefore, it may be used as a healing agent in different types of the wound in humans after certain clinical trials.
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http://dx.doi.org/10.1016/j.ijsu.2018.04.030DOI Listing
June 2018

A comparative study on the effect of "black cohosh" and "evening primrose oil" on menopausal hot flashes.

J Educ Health Promot 2018 1;7:36. Epub 2018 Mar 1.

MSc. of Midwifery consulting, Department of Midwifery, Hamadan University of Medical Sciences, Hamadan, Iran.

Introduction: Hot flashes are considered to be a common experience for menopausal women and they can compromise the quality of life. The objective of this study is to assess the efficacy of in comparison with evening primrose oil (EPO) in postmenopausal women with menopause-related symptoms.

Materials And Methods: This study was performed on 80 postmenopausal women with hot flashes. The participants were randomly divided into two groups by blocked randomization. The participants of one group received black cohosh and the other group received EPO for 8 weeks. The severity and number of hot flashes and quality of life were measured by four-point scale, and the Menopause-Specific Quality of Life (MENQOL) questionnaire at pre-intervention, 1, 4, and 8 weeks after treatment. Data were analyzed in SPSS Version 16 using independent -test, Chi-square, and Fisher's exact test.

Results: Average severity of hot flashes in both groups and number of hot flashes in black cohosh group in 8 week were significantly lower than 1 week ( < 0.001), but number of hot flashes in primrose oil group in 8 week showed no significant differences ( = 0.32). The number of hot flashes and quality of life score in black cohosh arm compared to EPO showed a significant decrease in the 8 week ( < 0.05). All MENQOL scores were significantly improved in two groups ( < 0.05), but the percentage of improvement in black cohosh arm was significantly superior to EPO group.

Conclusion: Both herbs were effective in reduction of severity of hot flashes and improvement of the quality of life, but it seems that black cohosh is more effective than primrose oil because it was able to reduce the number of hot flashes too.
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http://dx.doi.org/10.4103/jehp.jehp_81_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5868221PMC
March 2018

Cromolyn Sodium Attenuates Paraquat-Induced Lung Injury by Modulation of Proinflammatory Cytokines.

Drug Res (Stuttg) 2017 May 21;67(5):283-288. Epub 2017 Feb 21.

Department of Clinical Pharmacy, Faculty of Pharmacy, Isfahan University of Medical Sciences, Isfahan, Iran.

The current study aimed to investigate the effects of Cromolyn Sodium (CS) on proinflammatory cytokines in Paraquat (PQ)-induced lung damage in rat. Animals were randomly divided into 5 groups. Group 1 and 2 received nebulized vehicle and CS (8 mg/kg) for 3 consecutive weeks, respectively. Group 3 was treated with single oral dose of PQ (40 mg/kg). Groups 4 and 5 were PQ groups which received nebulized CS (6 and 8 mg/kg/day, respectively) from 1 week before to 2 weeks after PQ administration. Finally, the animals were scarified and the changes of hydroxyproline (HP) and histology were evaluated in lung tissue. In addition, IL-1β, TNF-α and IL-8 levels were determined in serum samples. The results showed that lung HP level as well as IL-1β, TNF-α and IL-8 were significantly lower in the CS treated rats as compared to PQ group. The best response, however, was observed with the 8 mg/kg of CS as confirmed by histology findings. This study suggests that CS may prevent progression of PQ-induced lung damage by decreasing of inflammatory cytokines.
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http://dx.doi.org/10.1055/s-0042-123711DOI Listing
May 2017

Comparison the Effect of Fish-Oil and Calcium Supplementation on Treatment of Primary Dysmenorrhea.

Rev Recent Clin Trials 2017 ;12(3):148-153

Department of Clinical Pharmacy, School of Pharmacy, Hamadan University of Medical Sciences, Hamadan. Iran.

Background: Primary dysmenorrhea is common among young girls and childbearing women. Dysmenorrhea is a painful contraction of uterus which occurs in the beginning of bleeding or before the menstrual cycle begins. Regarding the mechanism of calcium in response to hormonal change and the role of fish oil on reducing prostaglandins, we compared the effectiveness of fish-oil and calcium supplementation in treating primary dysmenorrheal.

Methods: This randomized double-blinded clinical trial was conducted on women aged 18 to 45 years with moderate to severe primary dysmenorrhea symptoms from January 2015 to March 2015. The women were randomly divided to two groups (fish oil and calcium). The drugs were given every day in the first cycle and from 8 days before till 2 days after initiation of menstruation for the second and third cycles. The intensity of pain and other symptoms of dysmenorreha were recorded and data were analyzed in SPSS 16 using T-test and X2 tests. Significant level was considered to be less than 0.05.

Results: The mean ± SD age of the patients in the fish oil group was 25.0±4.3 and in calcium group was 25.48±6.6 years. According to this result, there was no statistically significant difference in the intensity of pain between fish-oil group and calcium group before and 1 month after the study (P>0.05). However, there was statistically significant difference between fish-oil group and calcium group before the study and 2 months (P=0.001) and 3 months after study (p<0.001). Besides, the fishoil patients needed less analgesic as compared to the calcium patients.

Conclusion: It is concluded that omega-3 is more effective than calcium, what can be justified by pain mechanisms and symptoms pathology in dysmenorrheal.
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http://dx.doi.org/10.2174/1574887112666170328125529DOI Listing
August 2018

Evaluation of the Effects of Caffeic Acid Phenethyl Ester on Prostaglandin E2 and Two Key Cytokines Involved in Bleomycin-induced Pulmonary Fibrosis.

Iran J Basic Med Sci 2013 Jul;16(7):850-7

Department of Pharmacology and Toxicology, School of Pharmacy and Physiology Research Center, Jundishapur University of Medical Sciences, Ahvaz, Iran.

Objective(s): Pulmonary fibrosis (PF) is the most common outcome of a collection of diverse lung disorders known as interstitial lung diseases. It is proposed that alterations in the levels of fibrogenic mediators and the profibrotic/antifibrotic imbalance play a substantial role in the progression of PF in animal models and possibly in humans. Caffeic acid phenethyl ester (CAPE), an active component of propolis, has numerous biological effects. In the present study, the main objective was to investigate the effects of CAPE on some key mediators including TGF-β1, TNF-α and prostaglandin E2 (PGE2) involved in profibrotic/antifibrotic balance and pathogenesis of idiopathic pulmonary fibrosis (IPF).

Materials And Methods: In this study, forty male Sprague-Dawley rats were divided into 5 groups (n=8). (1) "Bleomycin (BLM)-treated (Model) group": BLM (5 mg/kg, single intratracheal dose), (2) "Saline-treated group": the rats were given only saline, (3) "Treatment-1 group": BLM + CAPE (5 μmol/kg/day, 28 days, IP), (4) "Treatment-2 group": BLM + CAPE (10 μmol/kg/day, 28 days, IP) and (5) "Vehicle + CAPE group": CAPE (10 μmol/kg/day, 28 days, IP).

Results: BLM could significantly increase the levels of TNF-α and TGF-β1 and decrease the PGE2 concentration compared to the saline control group. CAPE could considerably improve these values almost close to normal levels.

Conclusion: Briefly, CAPE can be suggested as a novel, attractive and effective agent for prevention and treatment of pulmonary fibrosis.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3758057PMC
July 2013