Amelie Lansiaux

Amelie Lansiaux

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Amelie Lansiaux

Publications by authors named "Amelie Lansiaux"

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Phenotypical characterization of peanut allergic children with differences in cross-allergy to tree nuts and other legumes.

Pediatr Allergy Immunol 2017 05 6;28(3):245-250. Epub 2017 Mar 6.

Service d'Allergologie et d'Education Thérapeutique, Hôpital Saint-Vincent de Paul, Lille Cedex, France.

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http://dx.doi.org/10.1111/pai.12698DOI Listing
May 2017

Human epidermal growth factor receptor 3 in head and neck squamous cell carcinomas.

Head Neck 2016 04 2;38 Suppl 1:E2412-8. Epub 2016 Feb 2.

Tumorigenesis and Resistance to Treatment Unit, Centre Oscar Lambret, Inserm U908, IRCL, Lille, France.

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http://dx.doi.org/10.1002/hed.24367DOI Listing
April 2016

Synthesis and biological activity of ferrocenyl indeno[1,2-c]isoquinolines as topoisomerase II inhibitors.

Bioorg Med Chem 2016 Feb 18;24(4):651-60. Epub 2015 Dec 18.

Univ. Lille, CNRS, Centrale Lille, ENSCL, Univ. Artois, UMR 8181-UCCS-Unité de Catalyse et Chimie du Solide, F-59000 Lille, France. Electronic address:

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http://dx.doi.org/10.1016/j.bmc.2015.12.033DOI Listing
February 2016

Synergistic Effect of SN-38 in Combination with Cetuximab on Angiogenesis and Cancer Cell Invasion.

Anticancer Res 2015 Nov;35(11):5983-91

Oscar Lambret Centre, Lille, France French National Institute of Health and Medical Research (INSERM U.837), Institute for Cancer Research of Lille, Lille, France Hospital Group of Lille Catholic Institute, Lille Catholic University, Lille, France.

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November 2015

Synthesis, antitumor activity, and mechanism of action of benzo[b]chromeno[6,5-g][1,8]naphthyridin-7-one analogs of acronycine.

J Med Chem 2014 Dec 9;57(24):10329-42. Epub 2014 Dec 9.

Laboratoire de Pharmacognosie, Université Paris Descartes , U.M.R./C.N.R.S. n° 8638, Faculté des Sciences Pharmaceutiques et Biologiques, 4 Avenue de l'Observatoire, 75006 Paris, France.

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http://dx.doi.org/10.1021/jm500927dDOI Listing
December 2014

Synthesis, antiproliferative activity and tubulin targeting effect of acridinone and dioxophenothiazine derivatives.

Eur J Med Chem 2013 Jan 8;59:39-47. Epub 2012 Nov 8.

Université Lille Nord de France, Faculté des Sciences Pharmaceutiques et Biologiques, Laboratoire de Chimie Thérapeutique, EA 4481, IFR 114, 3 rue du Professeur Laguesse, BP-83, F-59006 Lille, France.

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http://dx.doi.org/10.1016/j.ejmech.2012.10.051DOI Listing
January 2013

Synthesis of chromeno[3,4-b]indoles as Lamellarin D analogues: a novel DYRK1A inhibitor class.

Eur J Med Chem 2012 Mar 25;49:379-96. Epub 2012 Jan 25.

Institut de Chimie Organique et Analytique, Université d'Orléans, Orléans, France.

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http://dx.doi.org/10.1016/j.ejmech.2012.01.040DOI Listing
March 2012

Circulating thrombospondin 1 level as a surrogate marker in patients receiving cyclophosphamide-based metronomic chemotherapy.

Invest New Drugs 2012 Feb 7;30(1):403-4. Epub 2010 May 7.

Centre Oscar Lambret, 3, rue F Combemale, 59020 Lille, France.

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http://link.springer.com/10.1007/s10637-010-9443-1
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http://dx.doi.org/10.1007/s10637-010-9443-1DOI Listing
February 2012

Dual inhibition of MAGL and type II topoisomerase by N-phenylmaleimides as a potential strategy to reduce neuroblastoma cell growth.

Eur J Pharm Sci 2012 Feb 23;45(3):263-71. Epub 2011 Nov 23.

Université catholique de Louvain, Louvain Drug Research Institute (LDRI), Medicinal Chemistry Research Group (CMFA), 73 avenue E. Mounier, bte B1.73.10, 1200 Bruxelles, Belgium.

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http://dx.doi.org/10.1016/j.ejps.2011.11.011DOI Listing
February 2012

[Molecular determinants of response to topoisomerase II inhibitors].

Bull Cancer 2011 Nov;98(11):1299-310

Centre Oscar Lambret, Université Lille Nord de France.

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http://dx.doi.org/10.1684/bdc.2011.1475DOI Listing
November 2011

[Molecular determinants of response to topoisomerase I inhibitors].

Bull Cancer 2011 Nov;98(11):1287-98

Institut Bergonié, université de Bordeaux, France.

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http://dx.doi.org/10.1684/bdc.2011.1474DOI Listing
November 2011

[Antimetabolites].

Authors:
Amélie Lansiaux

Bull Cancer 2011 Nov;98(11):1263-74

Centre Oscar-Lambret, Université Lille Nord de France.

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http://www.john-libbey-eurotext.fr/medline.md?doi=10.1684/bd
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http://dx.doi.org/10.1684/bdc.2011.1476DOI Listing
November 2011

[The inhibitor of integrins Cilengitide: a new active drug in neuro-oncology].

Bull Cancer 2011 Oct;98(9):1083-90

Centre Oscar-Lambret, unité d'oncologie pédiatrique, Lille Cedex, France.

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http://www.john-libbey-eurotext.fr/medline.md?doi=10.1684/bd
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http://dx.doi.org/10.1684/bdc.2011.1429DOI Listing
October 2011

Synthesis, cytotoxicity and topoisomerase inhibition properties of multifarious aminoalkylated indeno[1,2-c]isoquinolin-5,11-diones.

Bioorg Med Chem Lett 2011 Apr 1;21(8):2259-63. Epub 2011 Mar 1.

EA CMF 4478, Université Lille 1-Lille Nord de France, Bat C3(2), Cité Scientifique, 59655 Villeneuve d'Ascq Cedex, France.

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http://dx.doi.org/10.1016/j.bmcl.2011.02.106DOI Listing
April 2011

Justification of the starting dose as the main determinant of accrual time in dose-seeking oncology phase 1 trials.

Invest New Drugs 2010 Dec 16;28(6):839-43. Epub 2009 Sep 16.

Département de Cancérologie Générale, Centre Oscar Lambret, 3, Rue F Combemale, 59020, Lille, France.

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http://dx.doi.org/10.1007/s10637-009-9317-6DOI Listing
December 2010

Synthesis and biological activities of new furo[3,4-b]carbazoles: potential topoisomerase II inhibitors.

Eur J Med Chem 2010 Nov 15;45(11):5428-37. Epub 2010 Sep 15.

Institut de Chimie Organique et Analytique, Université d'Orléans, CNRS UMR 6005, B.P. 6759, 45067 Orléans Cedex 2, France.

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http://dx.doi.org/10.1016/j.ejmech.2010.09.003DOI Listing
November 2010

Indeno[1,2-c]isoquinolin-5,11-diones conjugated to amino acids: Synthesis, cytotoxicity, DNA interaction, and topoisomerase II inhibition properties.

Bioorg Med Chem 2010 Nov 16;18(22):8119-33. Epub 2010 Aug 16.

EA CMF 4478, Université Lille Nord de France-Université Lille 1, Bât C3(2), Cité Scientifique, 59655 Villeneuve d'Ascq Cedex, France.

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http://dx.doi.org/10.1016/j.bmc.2010.08.025DOI Listing
November 2010

Synthesis and biological evaluation of new penta- and heptacyclic indolo- and quinolinocarbazole ring systems obtained via Pd(0) catalysed reductive N-heteroannulation.

Org Biomol Chem 2010 Oct 24;8(20):4625-36. Epub 2010 Aug 24.

Université de Reims-Champagne-Ardenne, Institut de Chimie Moléculaire de Reims, CNRS UMR 6229, Groupe BSMA, UFR de Pharmacie, 51 rue Cognacq-Jay, F-51096 Reims, Cedex, France.

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http://xlink.rsc.org/?DOI=c0ob00149j
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http://dx.doi.org/10.1039/c0ob00149jDOI Listing
October 2010

Montmorillonite K-10 catalyzed cyclization of N-ethoxycarbonyl-N'-arylguanidines: access to pyrimido[4,5-c]carbazole and pyrimido[5,4-b]indole derivatives.

Bioorg Med Chem Lett 2010 Jul 31;20(14):4244-7. Epub 2010 May 31.

Département de Chimie Moléculaire, UMR-5250 and ICMG FR-2607, CNRS-Université Joseph Fourier, BP 53, 38041 Grenoble cedex 9, France.

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http://dx.doi.org/10.1016/j.bmcl.2010.05.028DOI Listing
July 2010

Unusual cellular uptake of cytotoxic 4-hydroxymethyl-3-aminoacridine.

Eur J Med Chem 2009 Nov 4;44(11):4758-63. Epub 2009 Jul 4.

Faculté de médecine de Lille, IRCL and IMPRT, Inserm U837, Centre Oscar Lambret, Université Lille Nord de France, France.

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http://dx.doi.org/10.1016/j.ejmech.2009.06.034DOI Listing
November 2009

Synthesis and antitumoral activity of novel thiazolobenzotriazole, thiazoloindolo[3,2-c]quinoline and quinolinoquinoline derivatives.

Eur J Med Chem 2009 Oct 14;44(10):3858-65. Epub 2009 Apr 14.

Université de La Rochelle, UMR CNRS 6250 LIENSs, Equipe Molécules à Activités Biologiques, Avenue Michel Crépeau, 17042 La Rochelle, France.

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http://dx.doi.org/10.1016/j.ejmech.2009.04.012DOI Listing
October 2009

Synthesis, cytotoxicity, DNA interaction, and topoisomerase II inhibition properties of novel indeno[2,1-c]quinolin-7-one and indeno[1,2-c]isoquinolin-5,11-dione derivatives.

J Med Chem 2008 Jun 29;51(12):3617-29. Epub 2008 May 29.

UMR 8009 Chimie Organique et Macromoléculaire, Laboratoire de Chimie Organique Physique, Bâtiment C3(2), Université des Sciences et Technologies de Lille, 59655 Villeneuve d'Ascq, France.

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http://dx.doi.org/10.1021/jm800017uDOI Listing
June 2008

Synthesis and biological evaluation of novel oxophenylarcyriaflavins as potential anticancer agents.

Org Biomol Chem 2008 Jun 15;6(12):2108-17. Epub 2008 Apr 15.

Institut de Chimie Organique et Analytique, Université d'Orléans, CNRS UMR 6005, Rue de Chartres, BP 6759, 45067, Orléans Cedex 2, France.

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http://dx.doi.org/10.1039/b801121dDOI Listing
June 2008

Synthesis of 3,5-bis(2-indolyl)pyridine and 3-[(2-indolyl)-5-phenyl]pyridine derivatives as CDK inhibitors and cytotoxic agents.

Bioorg Med Chem 2008 May 17;16(9):4932-53. Epub 2008 Mar 17.

Institut de Chimie Organique et Analytique, (1) Université d'Orléans, (2) CNRS UMR 6005, Rue de Chartres, BP 6759, 45067 Orléans Cedex 2, France.

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http://dx.doi.org/10.1016/j.bmc.2008.03.034DOI Listing
May 2008

[Methodological approaches of clinical studies with targeted therapies].

Bull Cancer 2008 Feb;95(2):185-90

Département de cancérologie générale, Centre Oscar-Lambret, 3, rue F.-Combemale, 59020 Lille, France.

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http://dx.doi.org/10.1684/bdc.2008.0575DOI Listing
February 2008

Angiosarcomas and taxanes.

Curr Treat Options Oncol 2007 Dec 8;8(6):428-34. Epub 2007 Dec 8.

Département de Cancérologie Générale, Centre Oscar Lambret, 3, rue F Combemale, Lille 59020, France.

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http://dx.doi.org/10.1007/s11864-007-0042-0DOI Listing
December 2007

[Gemcitabine: from preclinic to clinic passing by pharmacokinetics].

Bull Cancer 2007 ;94 Spec No Actualites:S85-9

Service de Pharmacologie, Centre René Huguenin, 35, rue Dailly, 92210 Saint-Cloud.

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October 2007

[Pemetrexed: from preclinic to clinic].

Bull Cancer 2007 ;94 Spec No Actualites:S134-8

Laboratoire de Pharmacologie, Centre Oscar Lambret, 3 rue Frédéric Combemale, BP 307, 59020 Lille Cedex.

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October 2007

Novel stable camptothecin derivatives replacing the E-ring lactone by a ketone function are potent inhibitors of topoisomerase I and promising antitumor drugs.

Mol Pharmacol 2007 Aug 9;72(2):311-9. Epub 2007 May 9.

Institut National de la Santé et de la Recherche Médicale U837, Université de Lille 2, Facultéde Médecine, Institut de Médecine Prédictive et Recherche Thérapeutique, Lille, France.

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http://dx.doi.org/10.1124/mol.107.034637DOI Listing
August 2007

Design, synthesis and biological evaluation of new oligopyrrole carboxamides linked with tricyclic DNA-intercalators as potential DNA ligands or topoisomerase inhibitors.

Eur J Med Chem 2007 Jun 2;42(6):752-71. Epub 2007 Mar 2.

INSERM U837-JPARC, Equipe N degrees 4, Institut de Recherches sur le Cancer de Lille, Place de Verdun, 59045 Lille Cedex, France.

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http://dx.doi.org/10.1016/j.ejmech.2006.12.039DOI Listing
June 2007

Amino- and glycoconjugates of pyrido[4,3,2-kl]acridine. Synthesis, antitumor activity, and DNA binding.

Bioorg Med Chem 2006 Nov 1;14(22):7520-30. Epub 2006 Aug 1.

LEDSS UMR5616 & ICMG-FR2607, Université Joseph Fourier, BP53, 38041 Grenoble cedex 9, France.

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http://dx.doi.org/10.1016/j.bmc.2006.07.010DOI Listing
November 2006

Synthesis, antitumor activity, and mechanism of action of benzo[a]pyrano[3,2-h]acridin-7-one analogues of acronycine.

J Med Chem 2006 Jun;49(11):3383-94

Laboratoire de Pharmacognosie de l'Université René Descartes, U.M.R./C.N.R.S. No. 8638, Faculté des Sciences Pharmaceutiques et Biologiques, 4 Avenue de l'Observatoire, 75006 Paris, France.

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http://dx.doi.org/10.1021/jm0602007DOI Listing
June 2006

Synthesis and biological evaluation of novel phenylcarbazoles as potential anticancer agents.

J Med Chem 2006 Jan;49(2):789-99

Institut de Chimie Organique et Analytique, UMR CNRS 6005, Université d'Orléans, 45067 Orléans Cedex 2, France.

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http://dx.doi.org/10.1021/jm050945xDOI Listing
January 2006

[Histone-deacetylases inhibitors: from TSA to SAHA].

Bull Cancer 2006 Jan;93(1):27-36

Laboratoire de pharmacologie antitumorale, Centre Oscar-Lambret, et Unité 524 Inserm, place de Verdun, 59045 Lille.

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January 2006

Synthesis of 2,6-diphenylpyrazine derivatives and their DNA binding and cytotoxic properties.

Eur J Med Chem 2005 Dec 8;40(12):1206-13. Epub 2005 Sep 8.

Inserm U-524, Centre Oscar Lambret, IRCL, Place de Verdun, 59045 Lille, France.

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http://dx.doi.org/10.1016/j.ejmech.2005.07.003DOI Listing
December 2005

Synthesis of 2,5- and 3,5-diphenylpyridine derivatives for DNA recognition and cytotoxicity.

Eur J Med Chem 2005 Nov 13;40(11):1087-95. Epub 2005 Jun 13.

Institut de Chimie Organique et Analytique, UMR 6005, Université d'Orléans, B.P. 6759, 45067 Orléans cedex 2, France.

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http://dx.doi.org/10.1016/j.ejmech.2005.04.011DOI Listing
November 2005

Oxoazabenzo[de]anthracenes conjugated to amino acids: synthesis and evaluation as DNA-binding antitumor agents.

Bioconjug Chem 2005 Jul-Aug;16(4):949-58

INSERM U-524 et Laboratoire de Pharmacologie Antitumorale du Centre Oscar Lambret, IRCL, 59045 Lille, France.

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http://dx.doi.org/10.1021/bc050065xDOI Listing
November 2005

Induction of apoptosis by the plant alkaloid sampangine in human HL-60 leukemia cells is mediated by reactive oxygen species.

Eur J Pharmacol 2005 Nov 11;525(1-3):32-40. Epub 2005 Nov 11.

INSERM U-524 and Laboratoire de Pharmacologie Antitumorale du Centre Oscar Lambret, IRCL, 1 Place de Verdun, 59045 Lille, France.

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http://dx.doi.org/10.1016/j.ejphar.2005.09.050DOI Listing
November 2005

Selective inhibition of topoisomerase I and various steps of spliceosome assembly by diospyrin derivatives.

Mol Pharmacol 2005 Apr 29;67(4):1186-94. Epub 2004 Dec 29.

IGM-Centre National de la Recherche Scientifique-UMII, Unité Mixte de Recherche 5535, l'Institut Fédératif de Recherches 122, Montpellier, France.

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http://dx.doi.org/10.1124/mol.104.007633DOI Listing
April 2005

Lamellarin D: a novel pro-apoptotic agent from marine origin insensitive to P-glycoprotein-mediated drug efflux.

Cancer Lett 2005 Apr;221(2):165-75

Centre Oscar Lambret and INSERM U-524, IRCL, Institute for Cancer Research, Place de Verdun, Lille cedex F-59045, France.

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http://dx.doi.org/10.1016/j.canlet.2004.09.022DOI Listing
April 2005

Covalent binding of antitumor benzoacronycines to double-stranded DNA induces helix opening and the formation of single-stranded DNA: unique consequences of a novel DNA-bonding mechanism.

Mol Cancer Ther 2005 Jan;4(1):71-80

Institut National de la Santé et de la Recherche Médicale U-524 et Laboratoire de Pharmacologie Antitumorale du Centre Oscar Lambret, Institut de Recherches sur le Cancer de Lille, Place de Verdun, Lille 59045, France.

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January 2005

Targeting DNA with novel diphenylcarbazoles.

Biochemistry 2004 Dec;43(48):15169-78

INSERM U-524 et Laboratoire de Pharmacologie Antitumorale du Centre Oscar Lambret, IRCL, 59045 Lille, France.

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http://dx.doi.org/10.1021/bi048474oDOI Listing
December 2004

Novel antitumor indenoindole derivatives targeting DNA and topoisomerase II.

Biochem Pharmacol 2004 Nov;68(10):1911-22

INSERM U-524 et Laboratoire de Pharmacologie Antitumorale du Centre Oscar Lambret, IRCL, Lille 59045, France.

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http://dx.doi.org/10.1016/j.bcp.2004.07.008DOI Listing
November 2004

In vitro measurement of enzymatic markers as a tool to detect mouse cardiomyocytes injury.

Mem Inst Oswaldo Cruz 2004 Nov 12;99(7):697-701. Epub 2005 Jan 12.

Laboratório de Biologia Celular, Departamento de Ultra-estrutura e Biologia Celular, Instituto Oswaldo Cruz-Fiocruz, Av. Brasil 4365, 21040-900 Rio de Janeiro, RJ, Brazil.

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http://dx.doi.org/10.1590/s0074-02762004000700006DOI Listing
November 2004

Synthesis and cytotoxic activity of benzo[c][1,7] and [1,8]phenanthrolines analogues of nitidine and fagaronine.

Bioorg Med Chem 2004 Jul;12(14):3943-53

Laboratoire de Pharmacognosie de l'Université René Descartes, UMR/CNRS No. 8638, Faculté des Sciences Pharmaceutiques et Biologiques, 4 Avenue de l'Observatoire, 75006 Paris, France.

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http://dx.doi.org/10.1016/j.bmc.2004.04.038DOI Listing
July 2004

Alkaloids from Cassytha filiformis and related aporphines: antitrypanosomal activity, cytotoxicity, and interaction with DNA and topoisomerases.

Planta Med 2004 May;70(5):407-13

Laboratoire de Pharmacognosie, Unité d'Analyse Chimique et Physico-Chimique des Médicaments, Université Catholique de Louvain, Bruxelles, Belgium.

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http://www.thieme-connect.de/DOI/DOI?10.1055/s-2004-818967
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http://dx.doi.org/10.1055/s-2004-818967DOI Listing
May 2004

Topoisomerase I and II inhibitors control caspase-2 pre-messenger RNA splicing in human cells.

Mol Cancer Res 2004 Jan;2(1):53-61

INSERM U517, Faculty of Medicine, 7 Boulevard Jeanne d'Arc, 21000 Dijon, France.

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January 2004

Chromophore-modified bisnaphthalimides: DNA recognition, topoisomerase inhibition, and cytotoxic properties of two mono- and bisfuronaphthalimides.

Biochemistry 2003 Apr;42(14):4136-50

INSERM U-524 et Laboratoire de Pharmacologie Antitumorale du Centre Oscar Lambret, IRCL, Place de Verdun, 59045 Lille, France. bailly@ lille.inserm.fr

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http://dx.doi.org/10.1021/bi027415cDOI Listing
April 2003

4-Hydroxymethyl-3-aminoacridine derivatives as a new family of anticancer agents.

J Med Chem 2003 Mar;46(6):967-77

LEDSS, UMR CNRS 5616, Université Joseph Fourier, BP 53, 38041 Grenoble Cedex 9, France.

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http://pubs.acs.org/doi/abs/10.1021/jm020389w
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http://dx.doi.org/10.1021/jm020389wDOI Listing
March 2003

[A symphony for the camptothecins].

Bull Cancer 2003 Mar;90(3):239-45

Laboratoire de pharmacologie antitumorale, Centre Oscar-Lambret, Unité 524 Inserm, place de Verdun, 59045 Lille.

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March 2003

Design of a composite ethidium-netropsin-anilinoacridine molecule for DNA recognition.

Chembiochem 2003 Jan;4(1):50-61

INSERM U-524 et Laboratoire de Pharmacologie Antitumorale du Centre Oscar Lambret, IRCL, Place de Verdun, 59045 Lille, France.

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http://dx.doi.org/10.1002/cbic.200390014DOI Listing
January 2003

[Perspectives on the oncologist pharmacopoeia].

Bull Cancer 2003 Jan;90(1):25-30

Laboratoire de pharmacologie antitumorale du Centre Oscar-Lambret et Unité 524 Inserm, 1, place de Verdun, 59045 Lille France.

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January 2003

Distribution of furamidine analogues in tumor cells: targeting of the nucleus or mitochondria depending on the amidine substitution.

Cancer Res 2002 Dec;62(24):7219-29

Institut National de la Santé et de la Recherche Médicale U-524 et Laboratoire de Pharmacologie Antitumorale du Centre Oscar Lambret, 59045 Lille, France.

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December 2002

Alkylation of guanine in DNA by S23906-1, a novel potent antitumor compound derived from the plant alkaloid acronycine.

Biochemistry 2002 Aug;41(31):9911-20

INSERM U-524, Laboratoire de Pharmacologie Antitumorale du Centre Oscar Lambret, Institut de Recherches sur le Cancer, 1 Place de Verdun, Lille 59045, France.

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http://dx.doi.org/10.1021/bi020226+DOI Listing
August 2002

[Cl958].

Bull Cancer 2002 Jun;89(6):575-8

Laboratoire de pharmacologie antitumorale, Centre Oscar-Lambret, U. 524 Inserm, place de Verdun, 59045 Lille Cedex, France.

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June 2002

Distribution of furamidine analogues in tumor cells: influence of the number of positive charges.

J Med Chem 2002 May;45(10):1994-2002

INSERM U-524 et Laboratoire de Pharmacologie Antitumorale du Centre Oscar Lambret, IRCL, Place de Verdun, 59045 Lille, France.

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http://dx.doi.org/10.1021/jm010539nDOI Listing
May 2002

Induction of apoptosis in HL-60 leukemia and B16 melanoma cells by the acronycine derivative S23906-1.

Biochem Pharmacol 2002 Apr;63(8):1443-52

INSERM U-524 et Laboratoire de Pharmacologie Antitumorale du Centre Oscar Lambret, IRCL, Place de Verdun, 59045 Lille, France.

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http://dx.doi.org/10.1016/s0006-2952(02)00899-7DOI Listing
April 2002