Publications by authors named "Amelia J Eisch"

91Publications

Does chronic systemic injection of the DREADD agonists clozapine-N-oxide or Compound 21 change behavior relevant to locomotion, exploration, anxiety, and depression in male non-DREADD-expressing mice?

Neurosci Lett 2020 11 17;739:135432. Epub 2020 Oct 17.

Department of Anesthesiology and Critical Care Medicine, The Children's Hospital of Philadelphia (CHOP) Research Institute, Philadelphia, PA, 19104, USA; Department of Anesthesiology and Critical Care Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA. Electronic address:

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November 2020

Female and male rats readily consume and prefer oxycodone to water in a chronic, continuous access, two-bottle oral voluntary paradigm.

Neuropharmacology 2020 05 27;167:107978. Epub 2020 Jan 27.

Department of Anesthesiology and Critical Care, Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA; Department of Neuroscience, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA. Electronic address:

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May 2020

Indices of dentate gyrus neurogenesis are unaffected immediately after or following withdrawal from morphine self-administration compared to saline self-administering control male rats.

Behav Brain Res 2020 03 20;381:112448. Epub 2019 Dec 20.

Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, USA; Department of Anesthesiology and Critical Care Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA; Department of Neuroscience and Mahoney Institute for Neurosciences, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. Electronic address:

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March 2020

Optimizing brain performance: Identifying mechanisms of adaptive neurobiological plasticity.

Neurosci Biobehav Rev 2019 10 26;105:60-71. Epub 2019 Jul 26.

Posit Science Corporation, San Francisco, CA, 94111, USA. Electronic address:

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October 2019

Adult hippocampal neurogenesis is not necessary for the response to lithium in the forced swim test.

Neurosci Lett 2019 06 30;704:67-72. Epub 2019 Mar 30.

Department of Medicine, Division of Hematology-Oncology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA; Institute for Translational Medicine and Therapeutics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA. Electronic address:

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June 2019

Dentate gyrus neurogenesis ablation via cranial irradiation enhances morphine self-administration and locomotor sensitization.

Addict Biol 2018 03 19;23(2):665-675. Epub 2017 Jun 19.

Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, USA.

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March 2018

Re-evaluating the link between neuropsychiatric disorders and dysregulated adult neurogenesis.

Nat Med 2016 11 26;22(11):1239-1247. Epub 2016 Oct 26.

Department of Anesthesiology and Critical Care Medicine, Children's Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

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November 2016

A NAc for Spinal Adjustments After Cocaine or Stress.

Biol Psychiatry 2016 06;79(11):872-4

Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas. Electronic address:

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June 2016

Detection and Phenotypic Characterization of Adult Neurogenesis.

Cold Spring Harb Perspect Biol 2016 Mar 1;8(3):a025981. Epub 2016 Mar 1.

Center for Stem Cell and Regenerative Medicine, Rosalind Franklin University of Medicine and Science, North Chicago, Illinois 60064.

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March 2016

Chromatin Remodeling Factor Brg1 Supports the Early Maintenance and Late Responsiveness of Nestin-Lineage Adult Neural Stem and Progenitor Cells.

Stem Cells 2015 Dec 9;33(12):3655-65. Epub 2015 Oct 9.

Department of Psychiatry, The University of Texas Southwestern Medical Center, Dallas, Texas, USA.

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December 2015

Inducible knockout of Mef2a, -c, and -d from nestin-expressing stem/progenitor cells and their progeny unexpectedly uncouples neurogenesis and dendritogenesis in vivo.

FASEB J 2015 Dec 18;29(12):5059-71. Epub 2015 Aug 18.

*Department of Psychiatry and Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas, USA

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December 2015

Aberrant hippocampal neurogenesis contributes to epilepsy and associated cognitive decline.

Nat Commun 2015 Mar 26;6:6606. Epub 2015 Mar 26.

Department of Molecular Biology and Hamon Center for Regenerative Science and Medicine, UT Southwestern Medical Center, Dallas, Texas 75390, USA.

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March 2015

Chronic P7C3 treatment restores hippocampal neurogenesis in the Ts65Dn mouse model of Down Syndrome [Corrected].

Neurosci Lett 2015 Mar 7;591:86-92. Epub 2015 Feb 7.

Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX 75390,USA; Department of Neurology & Neurotherapeutics, University of Texas Southwestern Medical Center, Dallas, TX 75390-8813, USA. Electronic address:

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March 2015

Developmental and adult GAP-43 deficiency in mice dynamically alters hippocampal neurogenesis and mossy fiber volume.

Dev Neurosci 2014 26;36(1):44-63. Epub 2014 Feb 26.

Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Tex., USA.

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November 2014

Early postnatal in vivo gliogenesis from nestin-lineage progenitors requires cdk5.

PLoS One 2013 26;8(8):e72819. Epub 2013 Aug 26.

Department of Psychiatry, The University of Texas Southwestern Medical Center, Dallas, Texas, USA.

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June 2014

Depression and hippocampal neurogenesis: a road to remission?

Science 2012 Oct;338(6103):72-5

Department of Psychiatry, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390-9070, USA.

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October 2012

Cell-autonomous inactivation of the reelin pathway impairs adult neurogenesis in the hippocampus.

J Neurosci 2012 Aug;32(35):12051-65

Developmental Neurobiology and Regeneration Laboratory, IRB Barcelona, Parc Cientific de Barcelona, Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED, ISCIII), Department of Cell Biology, University of Barcelona, Barcelona E-08028, Spain.

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August 2012

Functional and mechanistic exploration of an adult neurogenesis-promoting small molecule.

FASEB J 2012 Aug 27;26(8):3148-62. Epub 2012 Apr 27.

Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9070, USA.

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August 2012

Methadone does not alter key parameters of adult hippocampal neurogenesis in the heroin-naïve rat.

Neurosci Lett 2012 May 1;516(1):99-104. Epub 2012 Apr 1.

Department of Psychiatry, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390-9070, USA.

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May 2012

Therapeutic application of neural stem cells and adult neurogenesis for neurodegenerative disorders: regeneration and beyond.

Eur J Neurodegener Dis 2012;1(3):335-351

Department of Psychiatry, UT Southwestern Medical Center, 5323 Harry Hines Blvd. Dallas, TX 74309-9070, USA.

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January 2012

The interesting interplay between interneurons and adult hippocampal neurogenesis.

Mol Neurobiol 2011 Dec 29;44(3):287-302. Epub 2011 Sep 29.

UT Southwestern Medical Center, Dallas, TX 75390-9070, USA.

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December 2011

Delayed reduction of hippocampal synaptic transmission and spines following exposure to repeated subclinical doses of organophosphorus pesticide in adult mice.

Toxicol Sci 2012 Jan 26;125(1):196-208. Epub 2011 Sep 26.

Department of Neurology & Neurotherapeutics, The University of Texas Southwestern Medical Center, Dallas, Texas 75390-8813, USA.

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January 2012

The neurogenesis hypothesis of affective and anxiety disorders: are we mistaking the scaffolding for the building?

Neuropharmacology 2012 Jan 19;62(1):21-34. Epub 2011 Sep 19.

Department of Psychiatry, UT Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390-9070, USA.

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January 2012

Not(ch) just development: Notch signalling in the adult brain.

Nat Rev Neurosci 2011 May;12(5):269-83

Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.

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May 2011

Ascl1 (Mash1) defines cells with long-term neurogenic potential in subgranular and subventricular zones in adult mouse brain.

PLoS One 2011 Mar 31;6(3):e18472. Epub 2011 Mar 31.

Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America.

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March 2011

Block of glucocorticoid synthesis during re-activation inhibits extinction of an established fear memory.

Neurobiol Learn Mem 2011 May 17;95(4):453-60. Epub 2011 Feb 17.

Department of Psychology, Memorial University of Newfoundland, 232 Elizabeth Ave., St. John's, Newfoundland A1B3X9, Canada.

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May 2011

Notch1 is required for maintenance of the reservoir of adult hippocampal stem cells.

J Neurosci 2010 Aug;30(31):10484-92

Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.

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August 2010

Focal cerebral ischemia induces a multilineage cytogenic response from adult subventricular zone that is predominantly gliogenic.

Glia 2010 Oct;58(13):1610-9

Department of Neurosciences, University of New Mexico Health Sciences Center, Albuquerque, NM 87131-0001, USA.

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October 2010

Adult hippocampal neurogenesis is functionally important for stress-induced social avoidance.

Proc Natl Acad Sci U S A 2010 Mar 22;107(9):4436-41. Epub 2010 Feb 22.

Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX 75390-9070, USA.

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March 2010

Epigenetics, hippocampal neurogenesis, and neuropsychiatric disorders: unraveling the genome to understand the mind.

Neurobiol Dis 2010 Jul 28;39(1):73-84. Epub 2010 Jan 28.

Department of Molecular Biology, University of Texas Southwestern Medical Center, TX 75390, USA.

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July 2010

Hippocampal neurogenesis as a target for the treatment of mental illness: a critical evaluation.

Neuropharmacology 2010 May 6;58(6):884-93. Epub 2010 Jan 6.

Department of Psychiatry, UT Southwestern Medical Center, Dallas, TX 75390-9070, USA.

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May 2010

Reduction of adult hippocampal neurogenesis confers vulnerability in an animal model of cocaine addiction.

J Neurosci 2010 Jan;30(1):304-15

Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9070, USA.

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January 2010

Making a neuron: Cdk5 in embryonic and adult neurogenesis.

Trends Neurosci 2009 Nov 24;32(11):575-82. Epub 2009 Sep 24.

Institute of Cell Biology, Department of Biology, ETH Zurich, Schafmattstrasse 18, 8093 Zurich, Switzerland.

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November 2009

Neurod1 is essential for the survival and maturation of adult-born neurons.

Nat Neurosci 2009 Sep 23;12(9):1090-2. Epub 2009 Aug 23.

Department of Molecular Biology and Cecil H. and Ida Green Center for Reproductive Biology Sciences, University of Texas Southwestern Medical Center, Dallas, Texas, USA.

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September 2009

Cell-intrinsic signals that regulate adult neurogenesis in vivo: insights from inducible approaches.

BMB Rep 2009 May;42(5):245-59

Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas, 75390-9070, USA.

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May 2009

Cdk5 is essential for adult hippocampal neurogenesis.

Proc Natl Acad Sci U S A 2008 Nov 18;105(47):18567-71. Epub 2008 Nov 18.

Department of Psychiatry, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390-9070, USA.

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November 2008

Adult neurogenesis, mental health, and mental illness: hope or hype?

J Neurosci 2008 Nov;28(46):11785-91

Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9070, USA.

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November 2008

Fate mapping and lineage analyses demonstrate the production of a large number of striatal neuroblasts after transforming growth factor alpha and noggin striatal infusions into the dopamine-depleted striatum.

Stem Cells 2008 Sep 12;26(9):2349-60. Epub 2008 Jun 12.

Udall Parkinson Disease Research Center of Excellence, Center for Neuroregeneration Research, McLean Hospital/Harvard Medical School, Belmont, Massachusetts, USA.

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September 2008

Varied access to intravenous methamphetamine self-administration differentially alters adult hippocampal neurogenesis.

Biol Psychiatry 2008 Dec 19;64(11):958-65. Epub 2008 May 19.

Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, CA 92037, USA.

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December 2008

Withdrawal from cocaine self-administration normalizes deficits in proliferation and enhances maturity of adult-generated hippocampal neurons.

J Neurosci 2008 Mar;28(10):2516-26

Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9070, USA.

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March 2008

Stress experienced in utero reduces sexual dichotomies in neurogenesis, microenvironment, and cell death in the adult rat hippocampus.

Dev Neurobiol 2008 Apr;68(5):575-89

Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, California, USA.

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April 2008

Dynamic expression of TrkB receptor protein on proliferating and maturing cells in the adult mouse dentate gyrus.

Hippocampus 2008 ;18(5):435-9

Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9070, USA.

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July 2008

Which way does the Wnt blow? Exploring the duality of canonical Wnt signaling on cellular aging.

Bioessays 2008 Feb;30(2):102-6

Department of Psychiatry, The University of Texas, Southwestern Medical Center, Dallas, TX 75390, USA.

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February 2008

Methamphetamine self-administration and voluntary exercise have opposing effects on medial prefrontal cortex gliogenesis.

J Neurosci 2007 Oct;27(42):11442-50

Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, California 92037, USA.

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October 2007

Adult neurogenesis: can analysis of cell cycle proteins move us "Beyond BrdU"?

Curr Pharm Biotechnol 2007 Jun;8(3):147-65

Department of Psychiatry, The University of Texas Southwestern Medical Center, Dallas, Texas 75390-9070, USA.

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June 2007

Electroconvulsive seizures stimulate glial proliferation and reduce expression of Sprouty2 within the prefrontal cortex of rats.

Biol Psychiatry 2007 Sep 6;62(5):505-12. Epub 2007 Mar 6.

Department of Psychiatry, Harvard Medical School and McLean Hospital, Belmont, Massachusetts 02478, USA.

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September 2007

Gender and endogenous levels of estradiol do not influence adult hippocampal neurogenesis in mice.

Hippocampus 2007 ;17(3):175-80

Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.

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April 2007

IRS2-Akt pathway in midbrain dopamine neurons regulates behavioral and cellular responses to opiates.

Nat Neurosci 2007 Jan 3;10(1):93-9. Epub 2006 Dec 3.

Department of Psychiatry and Center for Basic Neuroscience, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390-9070, USA.

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January 2007

Juvenile administration of methylphenidate attenuates adult hippocampal neurogenesis.

Biol Psychiatry 2006 Nov 7;60(10):1121-30. Epub 2006 Aug 7.

Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

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November 2006

Decreased adult hippocampal neurogenesis in the PDAPP mouse model of Alzheimer's disease.

J Comp Neurol 2006 Mar;495(1):70-83

Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9070, USA.

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March 2006

Opiates, psychostimulants, and adult hippocampal neurogenesis: Insights for addiction and stem cell biology.

Hippocampus 2006 ;16(3):271-86

Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9070, USA.

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May 2006

Differential expression and regulation of the cAMP-selective phosphodiesterase type 4A splice variants in rat brain by chronic antidepressant administration.

Eur J Neurosci 2005 Sep;22(6):1463-75

Department of Psychiatry and Pharmacology, Yale University School of Medicine, New Haven, CT 06508, USA.

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September 2005

Mood-stabilizing drugs: are their neuroprotective aspects clinically relevant?

Psychiatr Clin North Am 2005 Jun;28(2):399-414

Department of Psychiatry, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA.

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June 2005

Regional, cellular, and subcellular localization of RGS10 in rodent brain.

J Comp Neurol 2005 Jan;481(3):299-313

Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9070, USA.

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January 2005

Mouse models of Alzheimer's disease: insight into treatment.

Rev Neurosci 2004 ;15(5):353-69

Department of Psychiatry, University of Texas Southwestern Medical School, Dallas, TX 75390-9070, USA.

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January 2005

Chronic morphine induces premature mitosis of proliferating cells in the adult mouse subgranular zone.

J Neurosci Res 2004 Jun;76(6):783-94

Department of Psychiatry, The University of Texas Southwestern Medical Center at Dallas, Texas 75390, USA.

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June 2004

Brain-derived neurotrophic factor in the ventral midbrain-nucleus accumbens pathway: a role in depression.

Biol Psychiatry 2003 Nov;54(10):994-1005

Department of Psychiatry, The University of Texas Southwestern Medical Center, Texas, Dallas 75390-9070, USA.

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November 2003

Phospholipase Cgamma in distinct regions of the ventral tegmental area differentially modulates mood-related behaviors.

J Neurosci 2003 Aug;23(20):7569-76

Department of Psychiatry and Center for Basic Neuroscience, The University of Texas Southwestern Medical Center, Dallas, Texas 75390-9070, USA.

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August 2003

Involvement of the lateral hypothalamic peptide orexin in morphine dependence and withdrawal.

J Neurosci 2003 Apr;23(8):3106-11

Department of Psychiatry, and Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9070, USA.

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April 2003

Adult neurogenesis: implications for psychiatry.

Authors:
Amelia J Eisch

Prog Brain Res 2002 ;138:315-42

Department of Psychiatry, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390-9070, USA.

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December 2002

CREB activity in the nucleus accumbens shell controls gating of behavioral responses to emotional stimuli.

Proc Natl Acad Sci U S A 2002 Aug 6;99(17):11435-40. Epub 2002 Aug 6.

Department of Psychiatry and Center for Basic Neuroscience, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390-9070, USA.

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August 2002

Neurobiology of depression.

Neuron 2002 Mar;34(1):13-25

Department of Psychiatry and Center for Basic Neuroscience, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA.

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March 2002