Ambroise Wonkam

Ambroise Wonkam

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Ambroise Wonkam

Publications by authors named "Ambroise Wonkam"

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Sickle cell disease in Africa: an urgent need for longitudinal cohort studies.

Lancet Glob Health 2019 Oct 23;7(10):e1310-e1311. Epub 2019 Aug 23.

Department of Haematology and Blood Transfusion, Muhimbili University of Health and Allied Sciences, Dar-es-Salaam, Tanzania.

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http://dx.doi.org/10.1016/S2214-109X(19)30364-XDOI Listing
October 2019

Exploring the Role of Shared Decision Making in the Consent Process for Pediatric Genomics Research in Cameroon, Tanzania, and Ghana.

AJOB Empir Bioeth 2019 Jul-Sep;10(3):182-189. Epub 2019 Aug 5.

i Division of Human Genetics, Department of Pathology, University of Cape Town , Cape Town , South Africa.

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http://dx.doi.org/10.1080/23294515.2019.1645759DOI Listing
August 2019

Perceptions of parents of children with hearing loss of genetic origin in South Africa.

J Community Genet 2019 Jul 21;10(3):325-333. Epub 2018 Nov 21.

Division of Human Genetics, Falmouth Building, Faculty of Health Sciences, Department of Pathology, University of Cape Town, Observatory, Cape Town, 7925, South Africa.

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http://dx.doi.org/10.1007/s12687-018-0396-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6591331PMC
July 2019

Dissecting Mutation Prediction of Variants in African Genomes: Challenges and Perspectives.

Front Genet 2019 25;10:601. Epub 2019 Jun 25.

Department of Pathology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.

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http://dx.doi.org/10.3389/fgene.2019.00601DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6603221PMC
June 2019

Hydroxyurea-Induced miRNA Expression in Sickle Cell Disease Patients in Africa.

Front Genet 2019 28;10:509. Epub 2019 May 28.

Division of Human Genetics, Department of Pathology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.

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http://dx.doi.org/10.3389/fgene.2019.00509DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6568309PMC
May 2019

Noonan Syndrome in South Africa: Clinical and Molecular Profiles.

Front Genet 2019 16;10:333. Epub 2019 Apr 16.

Division of Human Genetics, Departments of Medicine and Pathology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.

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https://www.frontiersin.org/article/10.3389/fgene.2019.00333
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http://dx.doi.org/10.3389/fgene.2019.00333DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6477999PMC
April 2019

Post genome-wide association analysis: dissecting computational pathway/network-based approaches.

Brief Bioinform 2019 03;20(2):690-700

Division of Human Genetics, Department of Pathology, Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Private Bag, Rondebosch, 7700, Cape Town, South Africa; African Institute for Mathematical Sciences, 7945 Muizenberg, Cape Town, South Africa and Computational Biology Division, Department of Integrative Biomedical Sciences, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Medical School, Anzio Road, Observatory, 7925, Cape Town, South Africa.

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http://dx.doi.org/10.1093/bib/bby035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6556901PMC
March 2019

The Genetics of Warfarin Dose-Response Variability in Africans: An Expert Perspective on Past, Present, and Future.

OMICS 2019 Mar;23(3):152-166

1 Pharmacogenomics and Drug Metabolism Research Group, Division of Human Genetics, Department of Pathology, Institute of Infectious Disease and Molecular Medicine (IDM), Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.

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http://dx.doi.org/10.1089/omi.2019.0018DOI Listing
March 2019

Warfarin Dose and CYP2C Gene Cluster: An African Ancestral-Specific Variant Is a Strong Predictor of Dose in Black South African Patients.

OMICS 2019 01 19;23(1):36-44. Epub 2018 Dec 19.

1 Pharmacogenomics and Drug Metabolism Research Group, Division of Human Genetics, Department of Pathology & Institute of Infectious Disease and Molecular Medicine (IDM), Faculty of Health Sciences, University of Cape Town , Cape Town, South Africa .

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http://dx.doi.org/10.1089/omi.2018.0174DOI Listing
January 2019

Genetic Determinants of Dyslipidemia in African-Based Populations: A Systematic Review.

OMICS 2018 12;22(12):749-758

8 Division of Human Genetics, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.

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http://dx.doi.org/10.1089/omi.2018.0158DOI Listing
December 2018

The Role of Tumor Microenvironment in Chemoresistance: 3D Extracellular Matrices as Accomplices.

Int J Mol Sci 2018 Sep 20;19(10). Epub 2018 Sep 20.

Division of Medical Biochemistry and Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Anzio Road, Observatory, Cape Town 7925, South Africa.

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http://dx.doi.org/10.3390/ijms19102861DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6213202PMC
September 2018

Introducing in AJMG Part A: Case reports in diverse populations.

Am J Med Genet A 2018 07;176(7):1547-1548

Medical Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, USA.

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http://doi.wiley.com/10.1002/ajmg.a.40353
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http://dx.doi.org/10.1002/ajmg.a.40353DOI Listing
July 2018

Personalized Herbal Medicine? A Roadmap for Convergence of Herbal and Precision Medicine Biomarker Innovations.

OMICS 2018 06;22(6):375-391

1 Pharmacogenomics and Drug Metabolism Research Group, Division of Human Genetics, Department of Pathology and Institute for Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town , Cape Town, South Africa .

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http://dx.doi.org/10.1089/omi.2018.0074DOI Listing
June 2018

Williams-Beuren syndrome in diverse populations.

Am J Med Genet A 2018 05;176(5):1128-1136

Medical Genetics Branch, National Human Genome Research Institute, The National Institutes of Health, Bethesda, Maryland.

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http://doi.wiley.com/10.1002/ajmg.a.38672
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http://dx.doi.org/10.1002/ajmg.a.38672DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6007881PMC
May 2018

Genomics and Epigenomics of Congenital Heart Defects: Expert Review and Lessons Learned in Africa.

OMICS 2018 05;22(5):301-321

1 Division of Human Genetics, Department of Pathology, Faculty of Health Sciences, Institute for Infectious Disease and Molecular Medicine, University of Cape Town , Cape Town, South Africa .

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http://dx.doi.org/10.1089/omi.2018.0033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6016577PMC
May 2018

Chemoresistance to Cancer Treatment: Benzo-α-Pyrene as Friend or Foe?

Molecules 2018 04 17;23(4). Epub 2018 Apr 17.

Pharmacogenomics and Drug Metabolism Group, Division of Human Genetics, Department of Pathology, Faculty of Health Sciences, University of Cape Town, Anzio Road, Observatory 7925, Cape Town, South Africa.

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http://dx.doi.org/10.3390/molecules23040930DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6017867PMC
April 2018

Effects of vaccines in patients with sickle cell disease: a systematic review protocol.

BMJ Open 2018 03 25;8(3):e021140. Epub 2018 Mar 25.

Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa.

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http://dx.doi.org/10.1136/bmjopen-2017-021140DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5875604PMC
March 2018

Bush mint (Hyptis suaveolens) and spreading hogweed (Boerhavia diffusa) medicinal plant extracts differentially affect activities of CYP1A2, CYP2D6 and CYP3A4 enzymes.

J Ethnopharmacol 2018 Jan 21;211:58-69. Epub 2017 Sep 21.

Pharmacogenomics and Drug metabolism Research Group, Division of Human Genetics, Department of Pathology & Institute for Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Anzio Road, Observatory 7925, Cape Town, South Africa. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S03788741173194
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http://dx.doi.org/10.1016/j.jep.2017.09.023DOI Listing
January 2018

Clinical and genetic factors are associated with pain and hospitalisation rates in sickle cell anaemia in Cameroon.

Br J Haematol 2018 01 3;180(1):134-146. Epub 2017 Dec 3.

Non-Communicable Diseases Research Unit, South African Medical Research Council, Cape Town, South Africa.

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http://dx.doi.org/10.1111/bjh.15011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5847561PMC
January 2018

Public Health Burden of Hearing Impairment and the Promise of Genomics and Environmental Research: A Case Study in Ghana, Africa.

OMICS 2017 11;21(11):638-646

3 Division of Human Genetics, Department of Medicine, Faculty of Health Sciences, University of Cape Town , Cape Town, South Africa .

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http://dx.doi.org/10.1089/omi.2017.0145DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5915221PMC
November 2017

Clinical and genetic predictors of renal dysfunctions in sickle cell anaemia in Cameroon.

Br J Haematol 2017 08 3;178(4):629-639. Epub 2017 May 3.

Division of Human Genetics, Department of Pathology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.

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http://dx.doi.org/10.1111/bjh.14724DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5660286PMC
August 2017

Sickle Cell Disease.

N Engl J Med 2017 07;377(3):302-303

University of Cape Town, Cape Town, South Africa

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http://dx.doi.org/10.1056/NEJMc1706325DOI Listing
July 2017

The 22q11.2 Deletion Syndrome in Congenital Heart Defects: Prevalence of Microdeletion Syndrome in Cameroon.

Glob Heart 2017 06 13;12(2):115-120. Epub 2017 Mar 13.

Service of Genetic Medicine, Geneva University Hospitals, Geneva, Switzerland.

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http://dx.doi.org/10.1016/j.gheart.2017.01.003DOI Listing
June 2017

Sickle cell disease: tipping the balance of genomic research to catalyse discoveries in Africa.

Lancet 2017 Jun 15;389(10087):2355-2358. Epub 2017 Jun 15.

Division of Human Genetics and Institute of Infectious Diseases and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.

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http://dx.doi.org/10.1016/S0140-6736(17)31615-XDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5612389PMC
June 2017

SAR1a promoter polymorphisms are not associated with fetal hemoglobin in patients with sickle cell disease from Cameroon.

BMC Res Notes 2017 May 12;10(1):183. Epub 2017 May 12.

Division of Human Genetics, Department of Pathology, Faculty of Health Sciences, University of Cape Town, Anzio Road, Observatory, Cape Town, 7925, Republic of South Africa.

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http://dx.doi.org/10.1186/s13104-017-2502-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5427596PMC
May 2017

Is there a role for pharmacogenetics in the treatment of sickle cell disease?

Authors:
Ambroise Wonkam

Pharmacogenomics 2017 03 17;18(4):321-325. Epub 2017 Feb 17.

Division of Human Genetics, Department of Pathology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.

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http://dx.doi.org/10.2217/pgs-2016-0007DOI Listing
March 2017

A Genomic and Protein-Protein Interaction Analyses of Nonsyndromic Hearing Impairment in Cameroon Using Targeted Genomic Enrichment and Massively Parallel Sequencing.

OMICS 2017 02 11;21(2):90-99. Epub 2017 Jan 11.

1 Division of Human Genetics, Department of Pathology, Faculty of Health Sciences - University of Cape Town , Cap Town, South Africa .

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http://dx.doi.org/10.1089/omi.2016.0171DOI Listing
February 2017

Studies of novel variants associated with Hb F in Sardinians and Tanzanians in sickle cell disease patients from Cameroon.

Hemoglobin 2016 Nov 10;40(6):377-380. Epub 2016 Nov 10.

a Division of Human Genetics, Department of Pathology, Faculty of Health Sciences , University of Cape Town , Cape Town , South Africa.

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http://dx.doi.org/10.1080/03630269.2016.1251453DOI Listing
November 2016

An Expert Review of Pharmacogenomics of Sickle Cell Disease Therapeutics: Not Yet Ready for Global Precision Medicine.

OMICS 2016 10 16;20(10):565-574. Epub 2016 Sep 16.

1 Division of Human Genetics, Department of Pathology, Faculty of Health Sciences, University of Cape Town , Cape Town, Republic of South Africa.

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http://dx.doi.org/10.1089/omi.2016.0105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5067801PMC
October 2016

Genetics of Sickle Cell-Associated Cardiovascular Disease: An Expert Review with Lessons Learned in Africa.

OMICS 2016 10;20(10):581-592

1 Division of Human Genetics, Departments of Medicine and Pathology, Faculty of Health Sciences, University of Cape Town , Cape Town, South Africa .

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http://dx.doi.org/10.1089/omi.2016.0125DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5067873PMC
October 2016

African Lettuce (Launaea taraxacifolia) Displays Possible Anticancer Effects and Herb-Drug Interaction Potential by CYP1A2, CYP2C9, and CYP2C19 Inhibition.

OMICS 2016 09;20(9):528-37

1 Pharmacogenetics Research Group, Division of Human Genetics, Department of Pathology and Institute of Infectious Diseases and Molecular medicine, Faculty of Health Sciences, University of Cape Town , Cape Town, South Africa .

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http://www.liebertpub.com/doi/10.1089/omi.2016.0117
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http://dx.doi.org/10.1089/omi.2016.0117DOI Listing
September 2016

Current needs for human and medical genomics research infrastructure in low and middle income countries.

J Med Genet 2016 07 6;53(7):438-40. Epub 2016 Jan 6.

College of Sciences, University of Texas at San Antonio, San Antonio, Texas, USA.

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http://dx.doi.org/10.1136/jmedgenet-2015-103631DOI Listing
July 2016

In Vitro Reversible and Time-Dependent CYP450 Inhibition Profiles of Medicinal Herbal Plant Extracts Newbouldia laevis and Cassia abbreviata: Implications for Herb-Drug Interactions.

Molecules 2016 Jul 7;21(7). Epub 2016 Jul 7.

Division of Human Genetics, Department of Pathology & Institute for Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Anzio Road, Observatory 7925, Cape Town, South Africa.

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http://dx.doi.org/10.3390/molecules21070891DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6274561PMC
July 2016

Genetics of hearing loss in Africans: use of next generation sequencing is the best way forward.

Pan Afr Med J 2015 17;20:383. Epub 2015 Apr 17.

Division of Human Genetics, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.

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http://dx.doi.org/10.11604/pamj.2015.20.383.5230DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4499266PMC
April 2016

Hydroxyurea down-regulates BCL11A, KLF-1 and MYB through miRNA-mediated actions to induce γ-globin expression: implications for new therapeutic approaches of sickle cell disease.

Clin Transl Med 2016 Mar 7;5(1):15. Epub 2016 Apr 7.

Division of Human Genetics, Faculty of Health Sciences, University of Cape Town, Anzio Road, Observatory, Cape Town, 7925, Republic of South Africa.

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http://dx.doi.org/10.1186/s40169-016-0092-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4824700PMC
March 2016

Inhibition of CYP2B6 by Medicinal Plant Extracts: Implication for Use of Efavirenz and Nevirapine-Based Highly Active Anti-Retroviral Therapy (HAART) in Resource-Limited Settings.

Molecules 2016 Feb 16;21(2). Epub 2016 Feb 16.

Division of Human Genetics, Department of Pathology & Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Anzio Road, Observatory, Cape Town 7925, South Africa.

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http://dx.doi.org/10.3390/molecules21020211DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6273559PMC
February 2016

Perspectives in Genetics and Sickle Cell Disease Prevention in Africa: Beyond the Preliminary Data from Cameroon.

Public Health Genomics 2015 4;18(4):237-41. Epub 2015 Jun 4.

Division of Human Genetics, Faculty of Health Sciences, University of Cape Town, Cape Town, Republic of South Africa.

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http://dx.doi.org/10.1159/000431020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4514541PMC
October 2015

A systematic review of known mechanisms of hydroxyurea-induced fetal hemoglobin for treatment of sickle cell disease.

Expert Rev Hematol 2015 Oct 1;8(5):669-79. Epub 2015 Sep 1.

a 1 Department of Medicine, Division of Human Genetics, Faculty of Health Sciences, University of Cape Town, Cape Town, Republic of South Africa.

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http://dx.doi.org/10.1586/17474086.2015.1078235DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4829639PMC
October 2015

Pharmacogenomics Implications of Using Herbal Medicinal Plants on African Populations in Health Transition.

Pharmaceuticals (Basel) 2015 Sep 21;8(3):637-63. Epub 2015 Sep 21.

Division of Human Genetics, Department of Pathology & Institute of Infectious Diseases and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, Observatory 7925, South African.

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http://dx.doi.org/10.3390/ph8030637DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4588186PMC
September 2015

Treatment for sickle cell disease in Africa: should we invest in haematopoietic stem cell transplantation?

Pan Afr Med J 2014 13;18:46. Epub 2014 May 13.

Division of Human Genetics, Department of Clinical Laboratory Sciences, Faculty of Health Sciences, University of Cape Town (UCT), Cape Town, South Africa.

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http://dx.doi.org/10.11604/pamj.2014.18.46.3923DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4215374PMC
June 2015

Features of Turner syndrome among a group of Cameroonian patients.

Int J Gynaecol Obstet 2015 Jun 9;129(3):264-6. Epub 2015 Feb 9.

Faculty of Medicine and Biomedical Sciences, University of Yaoundé I, Yaoundé, Cameroon.

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http://dx.doi.org/10.1016/j.ijgo.2014.11.025DOI Listing
June 2015

A Global Health Diagnostic for Personalized Medicine in Resource-Constrained World Settings: A Simple PCR-RFLP Method for Genotyping CYP2B6 g.15582C>T and Science and Policy Relevance for Optimal Use of Antiretroviral Drug Efavirenz.

OMICS 2015 Jun;19(6):332-8

1 Pharmacogenetics and Cancer Research Group, Division of Human Genetics, Department of Clinical Laboratory Sciences and Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town , Cape Town, South Africa .

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http://dx.doi.org/10.1089/omi.2015.0039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4486718PMC
June 2015

Letter to the editor regarding "GJB2, GJB6 or GJA1 genes should not be investigated in routine in non syndromic deafness in people of sub-Saharan African descent".

Authors:
Ambroise Wonkam

Int J Pediatr Otorhinolaryngol 2015 Apr 20;79(4):632-3. Epub 2015 Jan 20.

Division of Human Genetics, Faculty of Health Sciences, University of Cape Town (UCT), South Africa. Electronic address:

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http://dx.doi.org/10.1016/j.ijporl.2015.01.012DOI Listing
April 2015

Polymorphism at BCL11A compared to HBS1L-MYB loci explains less of the variance in HbF in patients with sickle cell disease in Cameroon.

Blood Cells Mol Dis 2015 Mar 25;54(3):268-9. Epub 2014 Nov 25.

Division of Human Genetics, Faculty of Health Sciences, University of Cape Town (UCT), South Africa. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10799796140014
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http://dx.doi.org/10.1016/j.bcmd.2014.11.010DOI Listing
March 2015

Beta-globin gene haplotypes among cameroonians and review of the global distribution: is there a case for a single sickle mutation origin in Africa?

OMICS 2015 Mar;19(3):171-9

1 Department of Microbiology, Parasitology, and Hematology, Faculty of Medicine and Biomedical Sciences, University of Yaoundé , Yaoundé, Cameroon .

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http://dx.doi.org/10.1089/omi.2014.0134DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4356477PMC
March 2015

Association of variants at BCL11A and HBS1L-MYB with hemoglobin F and hospitalization rates among sickle cell patients in Cameroon.

PLoS One 2014 25;9(3):e92506. Epub 2014 Mar 25.

Department of Microbiology, Parasitology and Haematology, Faculty of Medicine and Biomedical Sciences, University of Yaoundé 1, Yaoundé, Cameroon.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0092506PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3965431PMC
January 2015

Psychosocial stressors of sickle cell disease on adult patients in Cameroon.

J Genet Couns 2014 Dec 21;23(6):948-56. Epub 2014 Feb 21.

Division of Human Genetics, Faculty of Health Sciences, University of Cape Town (UCT), Anzio road-7925, Observatory, Cape Town, South Africa,

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http://dx.doi.org/10.1007/s10897-014-9701-zDOI Listing
December 2014

Challenges in clinical diagnosis of williams-beuren syndrome in sub-saharan africans: case reports from cameroon.

Mol Syndromol 2014 Dec 29;5(6):287-92. Epub 2014 Nov 29.

Faculty of Medicine and Biomedical Sciences, University of Yaoundé I, Yaoundé, Cameroon ; Division of Human Genetics, University of Cape Town, Cape Town, South Africa.

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http://dx.doi.org/10.1159/000369421DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4281575PMC
December 2014

Would you terminate a pregnancy affected by sickle cell disease? Analysis of views of patients in Cameroon.

J Med Ethics 2014 Sep 5;40(9):615-20. Epub 2013 Aug 5.

Faculty of Medicine and Biomedical Sciences, University of Yaoundé I, Yaoundé, Cameroon.

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http://dx.doi.org/10.1136/medethics-2013-101392DOI Listing
September 2014

In search of genetic markers for nonsyndromic deafness in Africa: a study in Cameroonians and Black South Africans with the GJB6 and GJA1 candidate genes.

OMICS 2014 Jul 2;18(7):481-5. Epub 2014 May 2.

1 Division of Human Genetics, Department of Clinical Laboratory Sciences, Faculty of Health Sciences, University of Cape Town , Cape Town, South Africa .

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http://dx.doi.org/10.1089/omi.2013.0166DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4086242PMC
July 2014

Genomic medicine in Africa: promise, problems and prospects.

Genome Med 2014 24;6(2):11. Epub 2014 Feb 24.

Department of Medicine, University of Cape Town and Groote Schuur Hospital, Anzio Road, Observatory - 7925, Cape Town, South Africa.

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http://dx.doi.org/10.1186/gm528DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3979013PMC
July 2014

Cytochrome P450 pharmacogenetics in African populations: implications for public health.

Expert Opin Drug Metab Toxicol 2014 Jun 3;10(6):769-85. Epub 2014 Mar 3.

University of Cape Town, Faculty of Health Sciences, Pharmacogenetics and Cancer Research Group, Division of Human Genetics, Department of Clinical Laboratory Sciences , Anzio Road Observatory, 7925, Cape Town , South Africa +27 21 406 6506 ;

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http://dx.doi.org/10.1517/17425255.2014.894020DOI Listing
June 2014

Coinheritance of sickle cell anemia and α-thalassemia delays disease onset and could improve survival in Cameroonian's patients (Sub-Saharan Africa).

Am J Hematol 2014 Jun 10;89(6):664-5. Epub 2014 Apr 10.

Division of Human Genetics, Institute of Infectious Disease and Molecular Medicine (IDM), Faculty of Health Sciences, University of Cape Town (UCT), Cape Town, Republic of South Africa.

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http://dx.doi.org/10.1002/ajh.23711DOI Listing
June 2014

Research capacity. Enabling the genomic revolution in Africa.

Authors:
Charles Rotimi Akin Abayomi Alash'le Abimiku Victoria May Adabayeri Clement Adebamowo Ezekiel Adebiyi Adebowale D Ademola Adebowale Adeyemo Dwomoa Adu Dissou Affolabi Godfred Agongo Samuel Ajayi Sally Akarolo-Anthony Rufus Akinyemi Albert Akpalu Marianne Alberts Orlando Alonso Betancourt Ahmed Mansour Alzohairy Gobena Ameni Olukemi Amodu Gabriel Anabwani Kristian Andersen Fatiu Arogundade Oyedunni Arulogun Danny Asogun Rasheed Bakare Naby Balde Mary Lynn Baniecki Christine Beiswanger Alia Benkahla Lara Bethke Micheal Boehnke Vincent Boima James Brandful Andrew I Brooks Frank C Brosius Chester Brown Bruno Bucheton David T Burke Barrington G Burnett Stacy Carrington-Lawrence Nadia Carstens John Chisi Alan Christoffels Richard Cooper Heather Cordell Nigel Crowther Talishiea Croxton Jantina de Vries Leslie Derr Peter Donkor Seydou Doumbia Audrey Duncanson Ivy Ekem Ahmed El Sayed Mark E Engel John C K Enyaru Dean Everett Faisal M Fadlelmola Eyitayo Fakunle Kenneth H Fischbeck Anne Fischer Onikepe Folarin Junaid Gamieldien Robert F Garry Simani Gaseitsiwe Rasheed Gbadegesin Anita Ghansah Maria Giovanni Parham Goesbeck F Xavier Gomez-Olive Donald S Grant Ravnit Grewal Mark Guyer Neil A Hanchard Christian T Happi Scott Hazelhurst Branwen J Hennig Christiane Hertz- Fowler Winston Hide Friedhelm Hilderbrandt Christopher Hugo-Hamman Muntaser E Ibrahim Regina James Yasmina Jaufeerally-Fakim Carolyn Jenkins Ute Jentsch Pan-Pan Jiang Moses Joloba Victor Jongeneel Fourie Joubert Mukthar Kader Kathleen Kahn Pontiano Kaleebu Saidi H Kapiga Samar Kamal Kassim Ishmael Kasvosve Jonathan Kayondo Bernard Keavney Adeodata Kekitiinwa Sheik Humarr Khan Paul Kimmel Mary-Claire King Robert Kleta Mathurin Koffi Jeffrey Kopp Matthias Kretzler Judit Kumuthini Samuel Kyobe Catherine Kyobutungi Daniel T Lackland Karen A Lacourciere Guida Landouré Rita Lawlor Thomas Lehner Maia Lesosky Naomi Levitt Katherine Littler Zane Lombard Jeanne F Loring Sylvester Lyantagaye Annette Macleod Ebony B Madden Chengetai R Mahomva Julie Makani Manmak Mamven Marape Marape Graeme Mardon Patricia Marshall Darren P Martin Daniel Masiga Robin Mason Michael Mate-Kole Enock Matovu Mary Mayige Bongani M Mayosi Jean Claude Mbanya Sheryl A McCurdy Mark I McCarthy Helen McIlleron S O Mc'Ligeyo Corrine Merle Ana Olga Mocumbi Charles Mondo John V Moran Ayesha Motala Marva Moxey-Mims Wata Sununguko Mpoloka Chisomo L Msefula Thuli Mthiyane Nicola Mulder Gebregziab her Mulugeta Dieuodonne Mumba John Musuku Mo Nagdee Oyekanmi Nash Daouda Ndiaye Anh Quynh Nguyen Mark Nicol Oathokwa Nkomazana Shane Norris Betty Nsangi Alexander Nyarko Moffat Nyirenda Eileen Obe Reginald Obiakor Abraham Oduro Solomon F Ofori-Acquah Okechukwu Ogah Stephen Ogendo Kwaku Ohene-Frempong Akinlolu Ojo Timothy Olanrewaju John Oli Charlotte Osafo Odile Ouwe Missi Oukem-Boyer Bruce Ovbiagele Andrew Owen Mayowa Ojo Owolabi Lukman Owolabi Ellis Owusu-Dabo Guillaume Pare Rulan Parekh Hugh G Patterton Margaret B Penno Jane Peterson Rembert Pieper Jacob Plange-Rhule Martin Pollak Julia Puzak Rajkumar S Ramesar Michele Ramsay Rebekah Rasooly Shiksha Reddy Pardis C Sabeti Kwamena Sagoe Tunde Salako Oumar Samassékou Manjinder S Sandhu Osman Sankoh Fred Stephen Sarfo Marie Sarr Gasnat Shaboodien Issa Sidibe Gustave Simo Martin Simuunza Liam Smeeth Eugene Sobngwi Himla Soodyall Hermann Sorgho Oumou Sow Bah Sudha Srinivasan Dan J Stein Ezra S Susser Carmen Swanepoel Godfred Tangwa Andrew Tareila Ozlem Tastan Bishop Bamidele Tayo Nicki Tiffin Halidou Tinto Ekaete Tobin Stephen Meir Tollman Mahamadou Traoré Marsha J Treadwell Jennifer Troyer Masego Tsimako-Johnstone Vincent Tukei Ifeoma Ulasi Nzovu Ulenga Beverley van Rooyen Ablo Prudence Wachinou Salina P Waddy Alisha Wade Misaki Wayengera James Whitworth Louise Wideroff Cheryl A Winkler Sarah Winnicki Ambroise Wonkam Mengistu Yewondwos Tadase sen Nathan Yozwiak Heather Zar

Science 2014 Jun;344(6190):1346-8

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Current address: National Institutes of Health, Building 1, RM 256A, Bethesda MD 20892, USA.

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Prenatal diagnosis and termination of pregnancy: perspectives of South African parents of children with Down syndrome.

J Community Genet 2013 Jan 25;4(1):87-97. Epub 2012 Oct 25.

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Department of Clinical Laboratory Sciences, University of Cape Town, Cape Town, South Africa.

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Urethral duplication in a 12-year-old child.

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Initiation of prenatal genetic diagnosis of chromosomal anomalies in Cameroon.

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Faculty of Medicine and Biomedical Sciences, University of Yaoundé, Yaoundé Cameroon.

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Faculty of Medicine and Biomedical Sciences, University of Yaoundé I, Yaoundé, Cameroon.

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Are abdominal wall defects and external genitalia anomalies randomly expressed in some families?

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Division of Human Genetics, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.

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Frequency and clinical genetics of familial dilated cardiomyopathy in Cape Town: implications for the evaluation of patients with unexplained cardiomyopathy.

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Cardiac Clinic and Cardiovascular Genetics Laboratory, Hatter Institute for Cardiovascular Research in Africa, Department of Medicine, Groote Schuur Hospital, University of Cape Town.

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Clinical characteristics and outcomes of familial and idiopathic dilated cardiomyopathy in Cape Town: a comparative study of 120 cases followed up over 14 years.

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Cardiac Clinic, Department of Medicine, Groote Schuur Hospital, University of Cape Town.

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May 2011

Beyond the Caster Semenya controversy: the case of the use of genetics for gender testing in sport.

J Genet Couns 2010 Dec 8;19(6):545-8. Epub 2010 Sep 8.

Division of Human Genetics, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.

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http://dx.doi.org/10.1007/s10897-010-9320-2DOI Listing
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Inauguration of the cameroonian society of human genetics.

Pan Afr Med J 2009 Oct 20;3. Epub 2009 Oct 20.

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Acceptance of abortion by doctors and medical students in Cameroon.

Lancet 2007 Jun;369(9578):1999

Institute for Biomedical Ethics, Geneva University Medical School, Switzerland.

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Knowledge and attitudes concerning medical genetics amongst physicians and medical students in Cameroon (sub-Saharan Africa).

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The role of CFTR and SPINK-1 mutations in pancreatic disorders in HIV-positive patients: a case-control study.

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