Khartoum , Khartoum | Sudan
Main Specialties: Chemical Pathology
Additional Specialties: Endocrinology & Enzymology
3PubMed Central Citations
J Res Med Sci 2019 22;24:47. Epub 2019 May 22.
Department of Biochemistry and Molecular Biology, Faculty of Science and Technology, Al-Neelain University, Khartoum, Sudan.
Background: Vitamin D (VD) deficiency is associated with insulin function and secretion. It is linked with diabetes mellitus (DM) progression, and complications were also recorded. Therefore, the current study aimed to investigate serum VD level in Type 2 DM (T2DM) patients and its association with diabetic nephropathy and cardiovascular diseases (CVD).
Materials And Methods: In this cross-sectional study, 205 patients with Type 2 diabetes age ranged from 39 to 75 years old were enrolled. Serum VD, high-sensitivity C-reactive protein (hs-CRP), and hemoglobin A1c (HbA1c) were measured. In addition, urinary albumin:creatinine ratio (ACR) was estimated.
Results: Patients with Type 2 diabetes had a 78.5% VD level <30 ng/m. ACR and hs-CRP levels were significantly increased in patients with diabetes with VD <30 ng/m ( = 0.011 and = 0.008, respectively). Female had significantly lower VD level than male < 0.001. Patients exposed to sunlight had significantly higher VD level and lower hs-CRP levels compared with less-exposed, value (0.001 and <0.001), respectively. Exercise significantly increased VD and decreased ACR levels in DM patients, value (0.046 and 0.002), respectively. VD was positively associated with age ( = 0.355 = 0.040) and negatively correlate with BMI ( = -0.502 = 0.009), duration of disease ( = -0.498 = 0.003), ACR ( = -0.384 = 0.015), and HbA1c ( = -0.327 = 0.032).
Conclusion: The evidence from this study suggest that patients with Type 2 diabetes with VD deficiency are at higher risk for developing CVD and nephropathy.
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American Journal of Medicine and Medical Sciences 2015; 5(1): 1-6s
Background: High sensitive C-reactive protein (hs-CRP) is acute-phase protein which described as sensitive systemic marker of inflammation and tissue damage especially in cardiovascular disease (CVD). Vitamin D may reduce hypertension prevalence and its complication since vitamin D deficiency is associated with CVD, therefore this study aims to evaluate hs-CRP as a predictor marker for CVD in vitamin D deficient hypertensive patients. Materials and Methods: In cross-sectional study 176 hypertensive patients were enrolled (92 male, 84 female), then classified based on vitamin D results into normal (>20 ng/ml) and case (<20 ng/ml) groups. Serum vitamin D level was estimated using competitive ELISA assay and serum hs-CRP level was measured by Cobas C-311 automated analyzer, TG, HDL-C and total cholesterol were measured using enzymatic spectrophotometric methods whereas LDL-C and LDL:HDL ratio were calculated. Results: hs-CRP was significantly increased in vitamin D deficient compared to control group with p-value 0.049, also significantly higher in overweight hypertensive patient’s p-value 0.014. Vitamin D deficient was observed in female, overweight and >5 years duration of hypertension subjects in comparison with male, normal weight and <5 years with p-values (0.000, 0.005 and 0.041) respectively. Cholesterol was significantly higher in overweight group p-values 0.045, while LDL level was significantly higher and HDL was significantly lower in >5 years duration of hypertension. Conclusions: The study concludes hs-CRP is useful predictor marker for cardiovascular disease in vitamin D deficient hypertensive patients. Vitamin D deficient are more common in overweight and female hypertensive patients, which may increase risk of atherosclerosis, so monitoring of hs-CRP has predictor values.
Biochem Biotechnol Res, 2(4): 44-49
Net journal - Biochemistry and Biotechnology Research
Alnagma (dexamethasone) is locally abused by Sudanese women as cosmetics for gaining weight and whiten skin. The current study aims to evaluate the impact of Alnagma on steroid hormones, steroidogenesis and thus fertility in Female Wistar Rats. Eighteen female Wistar rats weighing (106.7 ± 6.2 g) were randomly divided into three groups, group I: received high dose dexamethasone (45 μg/kg/day), group II: received low dose (15 μg/kg/day) for one month and group III received placebo as control group, body weight was measured before treatment, day 14 and at day 30, serum estradiol, estrone and testosterone were measured using competitive ELISA technique, and the ovaries were examined using microscopic histopathological assay. Alnagma treated significantly decrease body weight, and increase mean estrone, testosterone and estradiol level (p-value < 0.05) in both low and high dose treated groups. Microscopic analysis showed increase luminal steroid hormones with hyperplasia of theca and granulosa cells. The study concludes that abuse of Alnagma increased testosterone which leads to infertility and estradiol prolonged luteal phase affecting menstrual cycle, while estrone increased susceptibility for breast, ovarian and endometrial cancers. Keywords: Dexamethasone, Alnagma, steroids, infertility, drugs abuse, Sudan.
Food Chem Toxicol 2013 Dec 23;62:817-24. Epub 2013 Oct 23.
Department of Pathology, Faculty of Medicine and Health Sciences, Al-Neelain University, 12702 Khartoum, Sudan; Department of Biochemistry, Faculty of Science and Technology, Al-Neelain University, 12702 Khartoum, Sudan. Electronic address:
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